keyword
https://read.qxmd.com/read/38515689/identification-of-prognostic-models-for-glycosylation-related-subtypes-and-tumor-microenvironment-infiltration-characteristics-in-clear-cell-renal-cell-cancer
#21
JOURNAL ARTICLE
Cheng Shen, Bing Zheng, Zhan Chen, Wei Zhang, Xinfeng Chen, Siyang Xu, Jianfeng Ji, Xingxing Fang, Chunmei Shi
BACKGROUND: One of the most fatal forms of cancer of the urinary system, renal cell carcinoma (RCC), significantly negatively impacts human health. Recent research reveals that abnormal glycosylation contributes to the growth and spread of tumors. However, there is no information on the function of genes related to glycosylation in RCC. METHODS: In this study, we created a technique that can be used to guide the choice of immunotherapy and chemotherapy regimens for RCC patients while predicting their survival prognosis...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38515313/the-effect-of-thyme-essential-oil-and-endothelial-progenitor-stem-cells-on-lipopolysaccharide-induced-sepsis-in-c57bl-6-mice
#22
JOURNAL ARTICLE
Mohammad Mehdi Soltan Dallal, Maryam Siavashi, Samira Karimaei, Vahid Siavashi, Milad Abdi, Mehdi Yaseri, Seyed Alireza Razavi, Ronak Bakhtiari
Sepsis is a potentially fatal syndrome related to severe systemic inflammation developed by infection. Despite different antimicrobial therapies, morbidity and mortality rates remain high. Herbs along with cell therapy have been introduced as a promising option to improve the symptoms of sepsis. The present study aimed to evaluate the therapeutic effect of simultaneous administration of thyme essential oil (TEO) and endothelial progenitor stem cells (EPCs) on lipopolysaccharide (LPS)-induced sepsis in C57BL/6 mice...
March 21, 2024: Biotechnology and Applied Biochemistry
https://read.qxmd.com/read/38515271/cardiopulmonary-bypass-associated-acute-kidney-injury-better-understanding-and-better-prevention
#23
REVIEW
Xutao Yang, Li Zhu, Hong Pan, Yi Yang
Cardiopulmonary bypass (CPB) is a common technique in cardiac surgery but is associated with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this review, we explore the range and definition of CPB-associated AKI and discuss the possible impact of different disease recognition methods on research outcomes. Furthermore, we introduce the specialized equipment and procedural intricacies associated with CPB surgeries. Based on recent research, we discuss the potential pathogenesis of AKI that may result from CPB, including compromised perfusion and oxygenation, inflammatory activation, oxidative stress, coagulopathy, hemolysis, and endothelial damage...
December 2024: Renal Failure
https://read.qxmd.com/read/38514261/-role-of-mitochondrial-autophagy-and-the-curative-effect-of-rehmannia-glutinosa-leaves-total-glycoside-capsules-on-nucleos-t-ide-drug-induced-renal-injury
#24
JOURNAL ARTICLE
K Zhong, M M Zhang, Z X Zhu, X Liao, B F Zhang, M L Cheng
Objective: To study the curative effect of rehmannia glutinosa leaves total glycoside capsules and the role of mitochondrial autophagy on nucleos(t)ide drug-induced renal injury. Methods: Adefovir dipivoxil (ADV) was used to construct a hepatitis B virus (HBV) transgenic mouse model for renal injury. Renal function was measured in each group at one and two weeks of modeling. Mitochondrial autophagy indicators were measured at two weeks of modeling in renal tissue. Transmission electron microscopy was used to detect mitochondrial autophagy phenomena in renal tissue...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38513825/change-over-time-in-pre-esrd-24-hour-urine-creatinine-as-muscle-mass-surrogate-and-post-esrd-mortality
#25
JOURNAL ARTICLE
Sahar Amin, Barry M Wall, Fridtjof Thomas, Kamyar Kalantar-Zadeh, Keiichi Sumida, Csaba P Kovesdy
OBJECTIVE: Loss of muscle mass and sarcopenia are common in CKD and ESRD, and sarcopenia can worsen insidiously in patients with advancing CKD. The temporal dynamics of sarcopenia in patients with progressive loss of kidney function, and its association with future outcomes, is unclear. METHODS: In a contemporary national cohort of incident ESRD US veterans, we selected 661 patients who had at least two 24-hour urine creatinine (24hrUC) measurements, a surrogate of muscle mass, performed during the 3-year prelude period prior to ESRD transition...
March 19, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38512913/comparison-of-ekfc-pakistani-ckd-epi-and-2021-race-free-ckd-epi-creatinine-equations-in-south-asian-ckd-population-a-study-from-pakistani-ckd-community-cohort
#26
JOURNAL ARTICLE
Aqsa Safdar, Waqas Akram, Mahtab Ahmad Khan, Danish Tahir, Muhammad Hammad Butt
INTRODUCTION: South Asian individuals possess a high risk of chronic kidney disease. There is a need to study, evaluate, and compare the newly suggested glomerular filtration rate (eGFR) equations for accurate CKD diagnosis, staging, and drug dosing. This study aimed to (1) evaluate the European Kidney Function Consortium (EKFC), Pakistani CKD-EPI, and 2021 Race-Free CKD-EPI creatinine equation in the South Asian population with CKD and (2) to examine the expected implications on both CKD classification as well as End Stage Renal Disease (ESRD) prevalence across these equations in South Asian population...
2024: PloS One
https://read.qxmd.com/read/38512760/investigation-of-the-relationship-of-nesfatin-1-adropin-levels-and-claudin-2-renalase-immunoreactivity-with-kidney-function-in-an-experimental-hypertension-model
#27
JOURNAL ARTICLE
Muhammed Ali Aydin, Nurettin Aydogdu, Ebru Tastekin, Nihayet Firat, Ozlem Yalcinkaya Yavuz
OBJECTIVE: Hypertension is one of the cardiovascular diseases that causes the most mortality, and 95% of the causes are unknown. The aim of the study was to examine the possible correlation of nesfatin-1 levels, adropin levels, claudin-2 immunoreactivity (claudin-2 expression in the renal proximal tubule), and renalase immunoreactivity (renalase expression in the renal proximal tubule) with arterial blood pressure, kidney function, and kidney damage. METHODS: Adult male Sprague Dawley rats were divided into control and hypertension groups (8 per group)...
March 2024: Puerto Rico Health Sciences Journal
https://read.qxmd.com/read/38512646/comparison-of-dynamic-measures-in-intraoperative-goal-directed-fluid-therapy-of-patients-with-morbid-obesity-undergoing-laparoscopic-sleeve-gastrectomy
#28
JOURNAL ARTICLE
Gökhan Urhan, İsmail Demirel, Ahmet Deniz, Ahmet Aksu, Aysun Yıldız Altun, Esef Bolat, Azize Beştaş, Gülsüm Altuntaş
INTRODUCTION: Obesity increases the risk of morbidity and mortality during surgical procedures. Goal-directed fluid therapy (GDFT) is a new concept for perioperative fluid management that has been shown to improve patient prognosis. This study aimed to investigate the role of the Pleth Variability Index (PVI), systolic pressure variation (SPV), and pulse pressure variation (PPV) in maintaining tissue perfusion and renal function during GDFT management in patients undergoing laparoscopic sleeve gastrectomy (LSG)...
March 21, 2024: Obesity Surgery
https://read.qxmd.com/read/38510762/acute-kidney-injury-in-patients-undergoing-extracorporeal-membrane-oxygenation-a-retrospective-cohort-study
#29
JOURNAL ARTICLE
Aswin Surjit, Bipi Prasannan, Jobin Abraham, Anuroop Balagopal, Vavullipathy Narayanan Unni
AIMS AND BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is a mode of extracorporeal therapy to support oxygenation of patients with severe cardiac or respiratory failure. Studies have shown that acute kidney injury (AKI) can worsen the outcome in these patients. This study aims to assess the incidence and outcome of AKI in patients on ECMO support. MATERIALS AND METHODS: This retrospective study included 64 patients who underwent ECMO for more than 24 hours...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38509240/increasing-obstructive-sleep-apnea-risk-is-associated-with-albuminuria-in-korean-adults-cross-sectional-analysis
#30
JOURNAL ARTICLE
Suk Won Chang, Ju Wan Kang
Several studies have shown an association between albuminuria and obstructive sleep apnea (OSA). However, studies on the relationship between the STOP-BANG questionnaire that can screen for OSA and microalbuminuria are still insufficient. Therefore, this study attempted to clarify the relationship between microalbuminuria and OSA risk using the STOP-BANG questionnaire in Korean adults. A total of 7478 participants (3289 men and 4189 women) aged over 40 were enrolled in the Korean National Health and Nutrition Examination Survey from 2019 to 2020...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38506982/association-of-serum-magnesium-levels-with-renal-prognosis-in-patients-with-chronic-kidney-disease
#31
JOURNAL ARTICLE
Seiji Kishi, Takaya Nakashima, Tadahiro Goto, Hajime Nagasu, Craig R Brooks, Hirokazu Okada, Kouichi Tamura, Toshiaki Nakano, Ichiei Narita, Shoichi Maruyama, Yuichiro Yano, Takashi Yokoo, Takashi Wada, Jun Wada, Masaomi Nangaku, Naoki Kashihara
BACKGROUND: Magnesium deficiency is associated with various health conditions, but its impact on the progression of chronic kidney disease (CKD) remains unclear. This study aimed to investigate the association between serum magnesium levels and prognosis of renal function in CKD patients. METHODS: This is an analysis of the Japan Chronic Kidney Disease Database Ex (J-CKD-DB-Ex), which is a multicenter prospective cohort including CKD patients enrolled from January 1, 2014 to December 31, 2020...
March 20, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38506068/long-noncoding-rna-glis2-regulates-podocyte-mitochondrial-dysfunction-and-apoptosis-in-diabetic-nephropathy-via-sponging-mir-328-5p
#32
JOURNAL ARTICLE
Ting Wang, Yanxia Chen, Zhihong Liu, Jing Zhou, Na Li, Yue Shan, Yinxi He
Podocyte apoptosis exerts a crucial role in the pathogenesis of DN. Recently, long noncoding RNAs (lncRNAs) have been gradually identified to be functional in a variety of different mechanisms associated with podocyte apoptosis. This study aimed to investigate whether lncRNA Glis2 could regulate podocyte apoptosis in DN and uncover the underlying mechanism. The apoptosis rate was detected by flow cytometry. Mitochondrial membrane potential (ΔΨM) was measured using JC-1 staining. Mitochondrial morphology was detected by MitoTracker Deep Red staining...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38504576/utility-of-a-fusion-protein-t-cell-co-stimulation-blocker-belatacept-in-heart-transplant-recipients-real-world-experience-from-a-high-volume-center
#33
JOURNAL ARTICLE
Daniel Oren, Matan Uriel, Cathrine M Moeller, Andrea Fernandez Valledor, Ersilia M DeFilippis, Dor Lotan, Paolo C Colombo, Melana Yuzefpolskaya, Veli K Topkara, Kevin J Clerkin, Jayant K Raikhelkar, Justin A Fried, David Kyung Taek Oh, David Bae, Eddie Lin, Kleanthis Theodoropoulos, Yoshifumi Naka, Koji Takeda, Jason Choe, Douglas L Jennings, David Majure, Farhana Latif, Gabriel Sayer, Nir Uriel
BACKGROUND: Belatacept (BTC), a fusion protein, selectively inhibits T-cell co-stimulation by binding to the CD80 and CD86 receptors on antigen-presenting cells (APCs) and has been used as immunosuppression in adult renal transplant recipients. However, data regarding its use in heart transplant (HT) recipients are limited. This retrospective cohort study aimed to delineate BTC's application in HT, focusing on efficacy, safety, and associated complications at a high-volume HT center. METHODS: A retrospective cohort study was conducted of patients who underwent HT between January 2017 and December 2021 and subsequently received BTC as part of their immunosuppressive regimen...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38504538/protective-effect-of-modified-huangqi-chifeng-decoction-on-immunoglobulin-a-nephropathy-through-toll-like-receptor-4-myeloid-differentiation-factor-88-nuclear-factor-kappa-b-signaling-pathway
#34
JOURNAL ARTICLE
L I Liusheng, Zhao Mingming, Chang Meiying, S I Yuan, Zhao Jinning, Yang Bin, Zhang Yu
OBJECTIVE: To examine the nephroprotective mechanism of modified Huangqi Chifeng decoction (, MHCD) in immunoglobulin A nephropathy (IgAN) rats. METHODS: To establish the IgAN rat model, the bovine serum albumin, lipopolysaccharide, and carbon tetrachloride 4 method was employed. The rats were then randomly assigned to the control, model, telmisartan, and high-, medium-, and low-dose MHCD groups, and were administered the respective treatments via intragastric administration for 8 weeks...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38504218/renal-toxicity-of-ifosfamide-in-children-with-cancer-an-exploratory-study-integrating-aldehyde-dehydrogenase-enzymatic-activity-data-and-a-wide-array-urinary-metabolomics-approach
#35
JOURNAL ARTICLE
Olivia Febvey-Combes, Jérôme Guitton, Perrine Marec-Berard, Cécile Faure-Conter, Ellen Blanc, Sylvie Chabaud, Agnès Conjard-Duplany, Matthias Schell, Laurence Derain Dubourg
BACKGROUND: Ifosfamide is a major anti-cancer drug in children with well-known renal toxicity. Understanding the mechanisms underlying this toxicity could help identify children at increased risk of toxicity. METHODS: The IFOS01 study included children undergoing ifosfamide-based chemotherapy for Ewing sarcoma or rhabdomyosarcoma. A fully evaluation of renal function was performed during and after chemotherapy. Proton nuclear magnetic resonance (NMR) and conventional biochemistry were used to detect early signs of ifosfamide-induced tubulopathy...
March 19, 2024: BMC Pediatrics
https://read.qxmd.com/read/38503613/efficacy-and-safety-of-tongxin-formula-after-stent-implantation-for-acute-coronary-syndrome-a-multicenter-double-blind-placebo-controlled-randomized-trial
#36
JOURNAL ARTICLE
Wen Zhu, Su Wang, Lei Zhang, Feng-Qun Xie, Jie Cheng, Xian-Kai Li, Wei Chen, Shi-Yun Yan, Qi-Mao Feng
OBJECTIVE: The aim of this study is to comprehensively evaluate both the efficacy and safety profile of integrating the Tongxin formula with optimal medical therapy (OMT) for patients experiencing acute coronary syndromes subsequent to coronary stenting, over the course of one year. METHODS: We enrolled 150 patients diagnosed with acute coronary syndromes who had received stent placement within one month and exhibited a TCM syndrome characterized by Qi deficiency and blood stasis...
March 1, 2024: Explore: the Journal of Science and Healing
https://read.qxmd.com/read/38503411/association-of-thyroid-autoantibodies-and-diabetic-kidney-disease-in-hospitalised-patients-with-type-2-diabetes-mellitus-a-cross-sectional-study-from-a-chinese-university-hospital
#37
JOURNAL ARTICLE
Zhi Wang, Futao Wang, Cong Liu, Le Zhang
OBJECTIVES: To analyse and explore the association between thyroid autoantibodies and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). DESIGN: A cross-sectional study. SETTING: Patients were from the inpatient unit at The Second Endocrinology Department of Shengjing Hospital Affiliated to China Medical University (Shenyang, China) between January 2015 and September 2019. PARTICIPANTS: A total of 150 Chinese adults with T2DM were included in the study, including 83 men and 67 women...
March 18, 2024: BMJ Open
https://read.qxmd.com/read/38500527/comparing-the-effects-of-empagliflozin-and-liraglutide-on-lipid-metabolism-and-intestinal-microflora-in-diabetic-mice
#38
JOURNAL ARTICLE
Qiong Yang, Ling Deng, Changmei Feng, Jianghua Wen
BACKGROUND AND OBJECTIVES: Recent studies have shown that the imbalance of intestinal flora is related to the occurrence and progression of diabetic nephropathy (DN) and can affect lipid metabolism. Sodium-dependent glucose transporters 2 (SGLT2) inhibitor and glucagon-like peptide-1 (GLP-1) receptor agonist are commonly used hypoglycemic drugs and have excellent renal safety. The purpose of this study was to compare the protective effects of empagliflozin and liraglutide on kidneys, lipid metabolism, and intestinal microbiota in diabetic mice...
2024: PeerJ
https://read.qxmd.com/read/38500195/kangxianling-formula-attenuates-renal-fibrosis-by-regulating-gut-microbiota
#39
JOURNAL ARTICLE
Pengyu Tao, Haiyan Liu, Guangjian Hou, Jianrao Lu, Yukun Xu
BACKGROUND: Renal fibrosis (RF) produced adverse effect on kidney function. Recently, intestinal dysbiosis is a key regulator that promotes the formation of renal fibrosis. This study will focus on exploring the protective mechanism of Kangxianling Formula (KXL) on renal fibrosis from the perspective of intestinal flora. METHODS: Unilateral Ureteral Obstruction (UUO) was used to construct rats' model with RF, and receive KXL formula intervention for 1 week...
March 18, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38497568/protracted-fibrinolysis-resistance-following-cardiac-surgery-with-cardiopulmonary-bypass-a-prospective-observational-study-of-clinical-associations-and-patient-outcomes
#40
JOURNAL ARTICLE
Lucy A Coupland, Kieran G Pai, Sidney J Pye, Mark T Butorac, Jennene J Miller, Philip J Crispin, David J Rabbolini, Antony H L Stewart, Anders Aneman
BACKGROUND: Surgery on cardiopulmonary bypass (CPB) elicits a pleiomorphic systemic host response which, when severe, requires prolonged intensive care support. Given the substantial cross-talk between inflammation, coagulation, and fibrinolysis, the aim of this hypothesis-generating observational study was to document the kinetics of fibrinolysis recovery post-CPB using ClotPro® point-of-care viscoelastometry. Tissue plasminogen activator-induced clot lysis time (TPA LT, s) was correlated with surgical risk, disease severity, organ dysfunction and intensive care length of stay (ICU LOS)...
March 18, 2024: Acta Anaesthesiologica Scandinavica
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