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Renal function measure

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https://www.readbyqxmd.com/read/29452887/protein-intake-and-long-term-change-in-glomerular-filtration-rate-in-the-jackson-heart-study
#1
Rakesh Malhotra, Loren Lipworth, Kerri L Cavanaugh, Bessie A Young, Katherine L Tucker, Teresa C Carithers, Herman A Taylor, Adolfo Correa, Edmond K Kabagambe, T Alp Ikizler
OBJECTIVE: Dietary protein intake could have deleterious renal effects in populations at risk for chronic kidney disease. Here, we examined whether higher protein intake (≥80th percentile of energy from protein) is associated with decline in kidney function and whether this decline varies by diabetes status. DESIGN: Observational cohort study. SUBJECTS AND SETTINGS: Participants were African-Americans (n = 5,301), who enrolled in the Jackson Heart Study between 2000 and 2004...
February 13, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29452835/a-comparison-of-preoperative-and-intraoperative-vein-mapping-sizes-for-arteriovenous-fistula-creation
#2
Samuel H Hui, Ryan Folsom, Lois A Killewich, Joel E Michalek, Mark G Davies, Lori L Pounds
BACKGROUND: Duplex ultrasound (DUS) mapping of the veins and arteries of the upper extremity is a well-established practice in arteriovenous fistula creation for long-term hemodialysis access. Previous publications have shown that vein diameters varying from 2 to 3 mm are predictive of success. Regional anesthesia is known to result in vasodilation and thus to increase the diameter of upper extremity veins. This study compares the sizes of veins measured by preoperative DUS mapping with those obtained after regional anesthesia to determine whether intraoperative DUS results in increased vein diameters and thus changes in the operative plan...
February 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29452086/ameliorative-effects-of-clonidine-on-ethanol-induced-kidney-injury-in-rats-potential-role-for-imidazoline-1-receptor
#3
Nesreen M I M Elkomy, Islam A A E-H Ibrahim, Shimaa M Elshazly, Hassan M El-Fayoumi
Chronic alcoholism is a risk factor for kidney injury. Clonidine is an α 2 -adrenergic receptor/imidazoline-1 receptor agonist that can reduce blood pressure and maintain renal functions. This study aims to investigate the possible ameliorative effects of clonidine on ethanol induced kidney injury and its mechanism of action. Kidney injury was induced in rats by adding ethanol to drinking water for eight weeks. Clonidine effects on kidney functions and histopathology were measured. Moreover, phentolamine (α-adrenergic receptor antagonist), efaroxan (imidazoline-1 receptor antagonist) and rilmenidine (imidazoline-1 receptor agonist) were used to clarify the role of imidazoline-1 receptor in mediating renal ameliorative effects...
February 13, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29451445/repeated-measurements-of-renal-function-in-evaluating-its-decline-in-cats
#4
Natalie C Finch, Harriet M Syme, Jonathan Elliott
Objectives The aim of this study was to describe the variability in renal function markers in non-azotaemic and azotaemic cats, and also the rate of change in the markers. Methods Plasma creatinine concentration and its reciprocal, glomerular filtration rate (GFR) and urine specific gravity (USG) were studied as markers of renal function in client-owned cats. GFR was determined using a corrected slope-intercept iohexol clearance method. Renal function testing was performed at baseline and a second time point...
February 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29451000/novel-automated-immune-turbidimetric-assay-for-routine-urinary-cystatin-c-determinations
#5
Balázs Szirmay, Péter Kustán, Zoltán Horváth-Szalai, Andrea Ludány, Ágnes Lakatos, Diána Mühl, István Wittmann, Attila Miseta, Gábor L Kovács, Tamás Kőszegi
AIM: There is no commercially available urinary cystatin-C (u-CYSC) test in the market. Therefore, we optimized and validated an automated immune turbidimetric test for u-CYSC measurements and investigated u-CYSC concentrations in acute and chronic diseases which might lead to renal tubular disorders. MATERIALS & METHODS: A particle-enhanced immune turbidimetric assay was adapted and validated on a Cobas 8000/c502 analyzer. Urine samples of different patient groups were also analyzed...
February 16, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29448006/plasma-triglycerides-as-a-risk-factor-for-chronic-kidney-disease-in-type-2-diabetes-mellitus-evidence-from-the-northeastern-of-thailand
#6
Sojib Bin Zaman, Mohd Anisul Karim, Naznin Hossain, Gulam Muhammed Al Kibria, Sheikh Mohammed Shariful Islam
AIMS: To investigate the observational association between plasma triglyceride and CKD in patients with T2DM. METHODS: A hospital-based retrospective registry was used to obtain data of 3748 T2DM patients from May 2016 to October 2016. Anthropometric measurements and biochemical reports of T2DM patients with CKD were obtained by data extraction of medical records. CKD was defined according to the estimated glomerular filtration rate (eGFR <60mL/min/1.73 m 2 )...
February 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29444517/acetyl-coa-synthetase-2-promotes-cell-migration-and-invasion-of-renal-cell-carcinoma-by-upregulating-lysosomal-associated-membrane-protein-1-expression
#7
Lv Yao, Xiaoqiang Guo, Yaoting Gui
BACKGROUND/AIMS: Reprogramming energy metabolism is an emerging hallmark of many cancers, and this alteration is especially evident in renal cell carcinomas (RCCs). However, few studies have been conducted on lipid metabolism. This study investigated the function and mechanism of lipid metabolism-related acetyl-CoA synthetase 2 (ACSS2) in RCC development, cell migration and invasion. METHODS: Quantitative real-time PCR (qRT-PCR) was used to determine the expression of ACSS2 in cancer tissue and adjacent tissue...
February 8, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29442538/serum-cystatin-c-level-is-associated-with-locomotive-syndrome-risk-and-can-be-an-early-predictor-in-community-living-people-the-yakumo-study
#8
Satoshi Tanaka, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Masaaki Machino, Kyotaro Ota, Taisuke Seki, Koji Suzuki, Yoshihiro Nishida, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama
OBJECTIVES: The locomotive syndrome (LS) risk has been recently proposed as a criterion for evaluating physical ability. Serum cystatin C level is an early renal function marker and a cardiovascular disease predictor. This study aimed to evaluate the relationship between serum cystatin C level and LS risk. METHODS: We enrolled 54 participants and conducted the two-step test, stand-up test, 25-question geriatric locomotive function scale, LS risk test, Timed Up and Go test, back muscle strength, grip strength, blood test, and serum cystatin C level measurement...
February 14, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29442346/modification-of-a-two-blood-sample-method-used-for-measurement-of-gfr-with-99mtc-dtpa
#9
Marian J Surma, Anna Płachcińska, Jacek Kuśmierek
BACKGROUND: Measurements of GFR may be performed with a slope/intercept method (S/I), using only two blood samples taken in strictly defined time points. The aim of the study was to modify this method in order to extend time intervals suitable for blood sampling. Modification was based on a variation of a Russel et al. model parameter, selection of time intervals suitable for blood sampling and assessment of uncertainty of calculated results. MATERIAL AND METHODS: Archived values of GFR measurements of 169 patients with different renal function, from 5...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29441989/modulated-function-of-multidrug-resistance-associated-proteins-in-cisplatin-induced-acute-renal-failure-rats
#10
A Matsushima, K Oda, N Mori, T Murakami
The effect of cisplatin-induced acute renal failure (ARF) on the function and expression of multidrug resistanceassociated proteins (MRPs) was evaluated in rats. Rats received an intraperitoneal injection of cisplatin (9 mg/kg), and the induction of ARF state with high plasma concentrations of indoxyl sulfate and creatinine was observed 72 h after cisplatin treatment. The function of MRPs in the liver, kidney and brain was evaluated by measuring the tissue accumulation and biliary excretion of 2,4-dintrophenyl-S-glutathione (DNP-SG), a substrate for MRPs, after administration of 1-chloro-2,4-dintrobenzene (CDNB), a precursor of DNP-SG, in rats...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441437/immune-checkpoint-blockade-the-new-frontier-in-cancer-treatment
#11
Jeffrey M Clarke, Daniel J George, Stacey Lisi, April K S Salama
Immune checkpoint blockers have revolutionized cancer treatment in recent years. These agents are now approved for the treatment of several malignancies, including melanoma, squamous and non-squamous non-small cell lung cancer, renal cell carcinoma, urothelial carcinoma, and head and neck squamous cell carcinoma. Studies have demonstrated the significant impact of immunotherapy versus standard of care on patient outcomes, including durable response and extended survival. The use of immunotherapy-based combination therapy has been shown to further extend duration of response and survival...
February 13, 2018: Targeted Oncology
https://www.readbyqxmd.com/read/29440922/is-the-light-at-the-end-of-the-tunnel-nigh-a-review-of-adpkd-focusing-on-the-burden-of-disease-and-tolvaptan-as-a-new-treatment
#12
REVIEW
Rashid A Barnawi, Rahaf Z Attar, Sultan S Alfaer, Osama Y Safdar
Autosomal dominant polycystic kidney disease (ADPKD) causes pathological cystic changes to the kidney and is characterized by numerous renal and systemic manifestations. ADPKD is the fourth most common renal disease requiring renal replacement therapy. In this report, we present a detailed review of ADPKD, with a particular focus on its major economic, psychological, and social burden in affected patients. Treatment of this disease has been based on prophylactic and supportive measures. However, in recent years, new drugs have emerged as promising agents that may retard the progression of ADPKD, such as tolvaptan...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29439931/does-low-protein-diet-influence-the-uremic-toxin-serum-levels-from-the-gut-microbiota-in-nondialysis-chronic-kidney-disease-patients
#13
Ana Paula Black, Juliana S Anjos, Ludmila Cardozo, Flávia L Carmo, Carla J Dolenga, Lia S Nakao, Dennis de Carvalho Ferreira, Alexandre Rosado, José Carlos Carraro Eduardo, Denise Mafra
OBJECTIVES: To evaluate the effects of low-protein diet (LPD) on uremic toxins and the gut microbiota profile in nondialysis chronic kidney disease (CKD) patients. DESIGN AND METHODS: Longitudinal study with 30 nondialysis CKD patients (stage 3-4) undergoing LPD for 6 months. Adherence to the diet was evaluated based on the calculation of protein equivalent of nitrogen appearance from the 24-hour urine analysis. Good adherence to LPD was considered when protein intake was from 90% to 110% of the prescribed amount (0...
February 10, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29437896/susceptibility-to-hypertensive-renal-disease-in-the-spontaneously-hypertensive-rat-is-influenced-by-2-loci-affecting-blood-pressure-and-immunoglobulin-repertoire
#14
Isha S Dhande, Stacy M Cranford, Yaming Zhu, Sterling C Kneedler, M John Hicks, Scott E Wenderfer, Michael C Braun, Peter A Doris
High blood pressure exerts its deleterious effects on health largely through acceleration of end-organ diseases. Among these, progressive loss of renal function is particularly important, not only for the direct consequences of kidney damage but also because loss of renal function is associated with amplification of other adverse cardiovascular outcomes. Genetic susceptibility to hypertension and associated end-organ disease is non-Mendelian in both humans and in a rodent model, the spontaneously hypertensive rat (SHR)...
February 5, 2018: Hypertension
https://www.readbyqxmd.com/read/29436671/protective-effect-of-curcumin-against-cyclosporine-a%C3%A2-induced-rat-nephrotoxicity
#15
Jianjun Huang, Xuping Yao, Guobin Weng, Honggang Qi, Xiaolei Ye
This study explored the potential value of curcumin, a natural product, in the protection of CsA‑induced nephrotoxicity. The aim of the present study was to investigate the effects of curcumin on Cyclosporine A (CsA)‑induced renal oxidative stress and determine the potential underlying molecular mechanisms of the renal protective effects of Cur. HK‑2 human renal cells were co‑treated with CsA and various doses of Cur. Cell survival rate was determined by an MTT assay, total cellular protein was collected and oxidative stress in cell homogenates was evaluated by determining the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH‑Px) and catalase (CAT), the levels of malondialdehyde (MDA) and reactive oxygen species (ROS), and total antioxidant capacity...
February 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29435868/ambulatory-blood-pressure-profiles-in-familial-dysautonomia
#16
Lior Goldberg, Bat-El Bar-Aluma, Alex Krauthammer, Ori Efrati, Yehonatan Sharabi
OBJECTIVE: Familial dysautonomia (FD) is a rare genetic disease that involves extreme blood pressure fluctuations secondary to afferent baroreflex failure. The diurnal blood pressure profile, including the average, variability, and day-night difference, may have implications for long-term end organ damage. The purpose of this study was to describe the circadian pattern of blood pressure in the FD population and relationships with renal and pulmonary function, use of medications, and overall disability...
February 12, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29434810/relationship-of-renal-morphology-on-3-dimensional-ultrasonography-with-renal-pathologic-findings-and-outcome-in-biopsy-proven-nephropathy
#17
Jianwei Xu, Sung Il Hwang, Hak Jong Lee, Ho Jun Chin
Kidney morphology has been used to estimate renal functions. The present study investigated the usefulness of kidney length and renal parenchymal volume (RPV) measured using three-dimensional ultrasonography (3-D USG) in estimating renal pathological findings, and the outcome in patients with nephropathy who underwent renal biopsy. In this study, 94 adult patients who had native kidney biopsy with 3-D USG results were included. The mean kidney length and RPV were independent factors of, and positively correlated to the estimated glomerular filtration rate (eGFR)...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434785/nephroprotective-effects-of-diacylglycerol-on-diabetic-nephropathy-in-type-2-diabetic-rats
#18
Jianpeng Li, Yongheng Yan, Duo Li, Xia Li, Xinying Lin, Zhenhua Liu, Tongcheng Xu, Fangling Du
Diacylglycerol (DAG) has been reported to reduce the serum lipid and glucose levels more effectively compared with triacylglycerol (TAG). The present study examined the long-term effects of dietary DAG on rats with type 2 diabetic nephropathy (DN). The type 2 DN model was established by administering a high-fat and high-calorie diet along with an intraperitoneal injection of 35 mg/kg body weight streptozocin, and the disease developed over the following 8 weeks. Sprague-Dawley rats were then randomly divided into the control, TAG, low-dose DAG (Low-DAG) and high-dose DAG (High-DAG) groups...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432674/shen-kang-protects-against-tacrolimus-induced-renal-injury
#19
Long Ye Zhang, Jian Jin, Kang Luo, Shang Guo Piao, Hai Lan Zheng, Ji Zhe Jin, Sun Woo Lim, Bum Soon Choi, Chul Woo Yang, Can Li
Background/Aims: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a rat model of chronic tacrolimus (TAC) nephropathy. Methods: Rats were treated daily with TAC (1.5mg/kg, subcutaneously) and SK (450 mg/kg, intravenously) for 4 weeks. The effects of SK on TAC-induced renal injury were assessed by measuring renal function, urine albumin excretion, histopathology, inflammatory cell infiltration, expression of profibrotic (transforming growth factor β1 [TGF-β1] and TGF-β inducible gene-h3 [βig-h3]) and proinflammatory cytokines, oxidative stress, and apoptotic cell death...
February 12, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29432378/low-perfusion-pressure-is-associated-with-renal-tubular-injury-in-infants-undergoing-cardiac-surgery-with-cardiopulmonary-bypass-a-secondary-analysis-of-an-observational-study
#20
Mirela Bojan, Maria C Basto Duarte, Vanessa Lopez, Laurent Tourneur, Stephanie Vicca, Marc Froissart
BACKGROUND: Earlier work on adults undergoing surgery with cardiopulmonary bypass suggests that there is a close relationship between the lower limit of the cerebral and renal autoregulation pressures. Although cerebral autoregulation during bypass in infants has been extensively investigated, the impact of bypass on kidney function is not well known. It is, nevertheless, acknowledged that the main pathophysiological process involved in cardiac surgery-related kidney damage is tubular injury, and that urine neutrophil gelatinase-associated lipocaline (uNGAL) is a reliable biomarker of injury...
February 9, 2018: European Journal of Anaesthesiology
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