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Renal function measure

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https://www.readbyqxmd.com/read/29931675/correlations-between-plasma-strontium-concentration-components-of-calcium-and-phosphate-metabolism-and-renal-function-in-type-2-diabetes-mellitus
#1
Y S Van den Berkhof, C M Gant, R Maatman, A De Graaf, G J Navis, S J L Bakker, G D Laverman
BACKGROUND: Renal function decline in diabetic kidney disease is accompanied by calcium and phosphate metabolism alterations. Whereas Strontium (Sr2+ ) has many similarities with calcium, little is known about Sr2+ in this respect. We studied the association of plasma Sr2+ concentration and parameters associated with an altered calcium and phosphate metabolism in diabetic kidney disease. MATERIALS AND METHODS: Plasma Sr2+ concentration was measured in 450 patients included in the DIAbetes and LifEstyle Cohort Twente-1...
June 21, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29930161/early-proteinuria-lowering-by-angiotensin-converting-enzyme-inhibition-predicts-renal-survival-in-children-with-ckd
#2
Sophie M van den Belt, Hiddo J L Heerspink, Valentina Gracchi, Dick de Zeeuw, Elke Wühl, Franz Schaefer
Background Although pharmacotherapeutic proteinuria lowering was found to be nephroprotective in adults, the predictive value of early drug-induced proteinuria reduction for long-term renal survival in pediatric CKD is unknown. We analyzed data from the ESCAPE Trial for a potential association between initial antiproteinuric effect of standardized angiotensin-converting enzyme (ACE) inhibition and renal disease progression in children with CKD. Methods In total, 280 eligible children with CKD stages 2-4 (mean age 11...
June 21, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29929904/diffusional-kurtosis-imaging-in-assessing-renal-function-and-pathology-of-iga-nephropathy-a-preliminary-clinical-study
#3
Y Liu, G-M-Y Zhang, X Peng, Y Wen, W Ye, K Zheng, X Li, H Sun, L Chen
AIM: To evaluate renal fibrosis in immunoglobulin A nephropathy (IgAN) using diffusion kurtosis imaging (DKI). MATERIALS AND METHODS: Twenty patients with biopsy-proven IgAN were enrolled. DKI was performed on a clinical 3 T magnetic resonance imaging (MRI) system, and region-of-interest measurements were conducted to determine mean kurtosis (K), mean diffusivity (D), and apparent diffusion coefficient (ADC) of the kidney cortex. Renal biopsy specimens were scored based on the severity of renal fibrosis...
June 18, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29925066/the-vasopressin-system-in-the-risk-of-diabetes-and-cardiorenal-disease-and-hydration-as-a-potential-lifestyle-intervention
#4
Sofia Enhörning, Olle Melander
BACKGROUND: Type 2 diabetes, chronic kidney disease (CKD) and its cardiovascular complications are increasing as health problems worldwide. These diseases are interrelated with overlapping occurrence and once diabetes is established, the risk of cardiorenal disease is dramatically elevated. Thus, a search for unifying modifiable risk factors is key for effective prevention. SUMMARY: Elevated fasting plasma concentration of vasopressin, measured with the marker copeptin, predicts new onset type 2 diabetes as well as renal function decline...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29924703/markers-of-renal-function-in-older-adults-completing-a-higher-protein-obesity-intervention-and-one-year-later-findings-from-the-measur-up-trial
#5
Kathryn N Porter Starr, Shelley R McDonald, Aubrey Jarman, Melissa Orenduff, Richard Sloane, Carl F Pieper, Connie W Bales
Increases in rates of obesity in the older population are hastening the development of chronic illnesses, including chronic kidney disease (CKD). However, obesity reduction in older adults is besought with concerns about the long-term benefit/risk, especially regarding loss of muscle mass and its impact on function. Higher protein intakes have been advocated to help offset the tendency for loss of muscle during weight reduction but this raises concerns about possible negative effects on older kidneys. We assessed markers of renal function in venous blood samples collected during a six-month randomized controlled weight loss trial of higher protein intake in obese (n = 67; BMI ≥ 30 kg/m2 ) older (≥60 years) adults with physical frailty and age-normal renal status (glomerular filtration rate [GFR] ≥ 45); the Control diet (0...
June 20, 2018: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29923767/the-protective-role-of-trpc6-knockout-in-the-progression-of-diabetic-kidney-disease
#6
Denisha Spires, Daria V Ilatovskaya, Vladislav Levchenko, Paula E North, Aron M Geurts, Oleg Palygin, Alexander Staruschenko
Diabetic kidney disease (DKD) is a chronic kidney pathology that leads to end stage renal disease. Previous studies from our laboratory indicate that there is an association between the development of DKD and the TRPC6 channel. Trpc6 expression and activity was increased in the streptozotocin (STZ)-treated Dahl Salt-sensitive (SS) rat, an established model of type 1 diabetes. Here, using a Trpc6 knock-out created on the SS rat background (SSTRPC6-/- ), we test the hypothesis that the absence of Trpc6 will protect podocytes and kidney function during the development of DKD...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29922633/kamikihito-improves-cancer-related-fatigue-by-restoring-balance-between-the-sympathetic-and-parasympathetic-nervous-systems
#7
Satoshi Tamada, Kyoko Ebisu, Sayaka Yasuda, Minoru Kato, Noriko Ninomiya, Takeshi Yamasaki, Taro Iguchi, Tatsuya Nakatani, Yasuyoshi Watanabe
Background: Cancer-related fatigue is one of the most prevalent symptoms that patients with cancer experience, but the mechanisms underlying it are unknown. We aimed to quantify and mechanistically evaluate the improvement in fatigue related to administration of the Kampo medicine, Kamikihito. Materials and methods: Initially, we recruited outpatients with urological diseases and compared fatigue levels of 37 patients with cancer with a control group of 23 volunteers who had recovered completely from cancer or who were being treated for dysuria...
June 2018: Prostate International
https://www.readbyqxmd.com/read/29922171/high-mobility-group-box-1-promotes-aortic-calcification-in-chronic-kidney-disease-via-the-wnt-%C3%AE-catenin-pathway
#8
Xiucai Jin, Shu Rong, Weijie Yuan, Lijie Gu, Jieshuang Jia, Ling Wang, Honglei Yu, Yifeng Zhuge
Vascular calcification (VC) is common in chronic kidney disease (CKD), where cardiovascular mortality remains the leading cause of death. Here, we examined the role of high-mobility group box1 (HMGB1), a nuclear DNA-binding protein involved in inflammation, in aortic calcification and renal dysfunction induced by high phosphate in a mouse model of CKD induced by 5/6 nephrectomy. HMGB1 and kidney function markers were measured by ELISA in the serum of CKD patients and in CKD mice. Sections of the aortas of mice were analyzed by immunofluorescence and Alizarin red staining, and protein lysates were generated to analyze the expression of related proteins in response to silencing of HMGB1 or β-catenin by western blotting...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29920874/the-importance-of-residual-kidney-function-in-haemodialysis-patients
#9
REVIEW
Jessica Kong, Matthew Davies, Peter Mount
In contrast to peritoneal dialysis, residual kidney function is commonly disregarded for haemodialysis patients, and not regularly monitored or taken into account in routine clinical care. This is despite evidence that higher levels of residual kidney function in haemodialysis patients associate with better outcomes including survival, total solute clearance, nutrition, inflammation, and fluid balance. This review aims to summarise the clinical effects of residual kidney function specifically in haemodialysis patients...
June 19, 2018: Nephrology
https://www.readbyqxmd.com/read/29917254/erectile-function-and-gonadal-hormones-levels-in-men-with-end-stage-renal-disease-it-s-relevance-to-duration-of-haemodialysis
#10
Abul-Fotouh Ahmed, Mahmoud Shaban, Abdullah Daoud, Nagah Mohamed, Ahmed Solyman, Ahmed Fahim
In this study, we evaluated the relationship between haemodialysis (HD) duration and erectile function status and gonadal hormones serum levels in adult men with end-stage renal disease (ESRD). A total of 118 men with ESRD on chronic HD were eligible for analysis. The erectile dysfunction (ED) was defined and graded according to the international index of erectile function (IIEF-5) score. The serum levels of follicle stimulating hormones (FSH), luteinising hormone (LH), testosterone (TST), prolactin (PRL) and estradiol (E2) were measured using the standard laboratory technique...
June 19, 2018: Andrologia
https://www.readbyqxmd.com/read/29917152/glomerular-filtration-rate-in-patients-with-multiple-sclerosis-undergoing-stem-cell-transplantation-and-treated-with-cyclophosphamide
#11
Alejandro Ruiz-Argüelles, Jose M Gastélum-Cano, Mariana A Méndez-Huerta, Alma B Rodríguez-Gallegos, Guillermo J Ruiz-Argüelles
Background: Glomerular filtration rate (GFR) is partially impaired in patients with multiple sclerosis (MS). When given chemotherapy before receiving hematopoietic stem-cell transplantation, GFR might be further deteriorated. Objective: To measure the effect of cyclophosphamide on GFR in patients with MS who undergo chemotherapy. Methods: We estimated GFR based on creatinine and cystatin C plasma concentrations in patients undergoing autologous hematopoietic stem-cell transplantation to treat their MS...
June 15, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29914255/serum-vasohibin-1-and-suppression-of-tumorigenicity-2-levels-in-children-with-predialysis-chronic-kidney-disease
#12
Nuran Çetin, Nadide Melike Sav
Background/aim: Chronic kidney disease (CKD), which is one of the most important health problems worldwide, could be considered as an immune inflammatory disease. A prognostic biomarker may be helpful in determining the progression of CKD in children. We aimed to investigate the serum vasohibin-1 and soluble suppression of tumorigenicity-2 (sST2) levels as potential biomarkers in children with predialysis CKD. Materials and methods: Forty-seven children with stage 2-4 CKD and 20 healthy controls were included in this cross-sectional study...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29914158/mediterranean-diet-score-associations-with-metabolic-products-of-the-intestinal-microbiome-carotid-plaque-burden-and-renal-function
#13
Michael Pignanelli, Caroline Just, Chrysi Bogiatzi, Vincent Dinculescu, Gregory B Gloor, Emma Allen-Vercoe, Gregor Reid, Bradley L Urquhart, Kelsey N Ruetz, Thomas J Velenosi, J David Spence
Metabolic products of the intestinal microbiome such as trimethylamine N-oxide (TMAO) that accumulate in renal failure (gut-derived uremic toxins, GDUTs) affect atherosclerosis and increase cardiovascular risk. We hypothesized that patients on a Mediterranean diet and those consuming lower amounts of dietary precursors would have lower levels of GDUTs. Patients attending vascular prevention clinics completed a Harvard Food Frequency Questionnaire (FFQ) and had plasma levels of TMAO, p-cresylsulfate, hippuric acid, indoxyl sulfate, p-cresyl glucuronide, phenyl acetyl glutamine, and phenyl sulfate measured by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry...
June 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29913326/serum-cystatin-c-concentration-measured-routinely-is-a-prognostic-marker-for-renal-disease-in-dogs
#14
Naoki Iwasa, Satoshi Takashima, Tatsuo Iwasa, Kazuko Iwasa, Tomomi Suzuki, Yui Kobatake, Hitoshi Kitagawa, Naohito Nishii
This study examined the predictive value of serum cystatin C (Cys-C) concentration, measured during routine periodic health examinations, in the renal prognosis of dogs. A cohort of 140 dogs weighing <15 kg whose serum Cys-C concentrations were measured during periodic health examinations from December 2013 to March 2016 were prospectively studied, with renal disease-related death the predicted end point. Of the 140 dogs, nine died from renal diseases during the follow-up period (539 ± 249 days)...
June 14, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29910844/comparing-treatment-modalities-for-end-stage-renal-disease-a-meta-analysis
#15
Gilbert L Queeley, Ellen S Campbell
Background: End-stage renal disease (ESRD) imposes significant economic and social burdens on patients and healthcare systems. In the United States alone, more than 600,000 Americans have ESRD, with an estimated annual cost of treatment of more than $30 billion. Peritoneal dialysis and hemodialysis are competing renal replacement therapies in ESRD; however, data comparing quality-of-life outcomes between these 2 modalities are limited. Objectives: To compare the effectiveness of peritoneal dialysis with the more common treatment modality of hemodialysis on the health-related quality of life (HRQoL) of patients with ESRD in the general, physical, and psychological domains; and to determine whether the time of publication and the origin of each study influenced its findings regarding the effectiveness of the 2 modalities...
May 2018: American Health & Drug Benefits
https://www.readbyqxmd.com/read/29907783/protective-effect-of-hydroxysafflor-yellow-a-against-acute-kidney-injury-via-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Juan Bai, Jinyi Zhao, Dongxiao Cui, Fan Wang, Ying Song, Lianghua Cheng, Kai Gao, Jin Wang, Long Li, Shujun Li, Yanyan Jia, Aidong Wen
This study aimed to evaluate the protective effect of hydroxysafflor yellow A (HSYA) on ischemia/reperfusion (I/R)-induced acute kidney injury via the TLR4/NF-κB pathway, both in vitro and in vivo. Rats were subjected to removal of the right kidney and I/R injury to the left kidney. Rats subjected to renal I/R injury were treated with HSYA at 0.5 h prior to I/R injury. Renal function, histopathological analysis, and cells apoptosis were measured in vivo. In vitro, proximal renal tubular cells (HK-2) were subjected to hypoxia/reoxygenation (H/R)...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907406/first-spot-urine-sodium-after-initial-diuretic-identifies-patients-at-high-risk-for-adverse-outcome-after-heart-failure-hospitalization
#17
Adriana Luk, John D Groarke, Akshay S Desai, Syed Saad Mahmood, Deepa M Gopal, Emer Joyce, Sachin P Shah, Joann Lindenfeld, Lynne Stevenson, Neal K Lakdawala
BACKGROUND: Relief of congestion is the primary goal of initial therapy for acute decompensated heart failure (ADHF). Early measurement of urine sodium concentration (UNa) may be useful to identify patients with diminished response to diuretics. The aim of this study was to determine if the first spot UNa after diuretic initiation could select patients likely to require more intensive therapy during hospitalization. METHODS: At the time of admission, 103 patients with ADHF were identified prospectively, and UNa was measured after the first dose of intravenous diuretic...
May 19, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29907091/end-stage-renal-disease-treated-in-provence-alpes-c%C3%A3-te-d-azur-12-years-follow-up-and-forecast-to-the-year-2030
#18
Anne-Claire Durand, Elisabeth Jouve, Jean-Christophe Delarozière, Mohamed Boucekine, Ghizlane Izaaryene, Adeline Crémades, Franck Mazoué, Bénédicte Devictor, Asmatullah Kakar, Roland Sambuc, Philippe Brunet, Stéphanie Gentile
BACKGROUND: This study describes the time trend of renal replacement therapy for end-stage renal disease (ESRD) in the Provence-Alpes Côte d'Azur region (PACA) between 2004 and 2015, and forecasts up to 2030. METHODS: A longitudinal study was conducted on all ESRD patients treated in PACA and recorded in the French Renal Epidemiology and Information Network (REIN) during this period. Time trends and forecasts to 2030 were analyzed using Poisson regression models...
June 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29904040/a-pilot-trial-to-examine-the-changes-in-carotid-arterial-inflammation-in-renal-transplant-recipients-as-assessed-by-18f-fluorodeoxyglucose-18f-fdg-positron-emission-tomography-computed-tomography-pet-ct
#19
Hye Eun Yoon, Yaeni Kim, Sang Dong Kim, Jin Kyoung Oh, Yong-An Chung, Seok Joon Shin, Chul Woo Yang, Suk Min Seo
BACKGROUND Inflammatory activity of the artery can be assessed by measuring 18F-fluorodeoxyglucose (18F-FDG) uptake with positron emission tomography computed tomography (PET/CT). Improvement in vascular function after renal transplantation has been reported, but no studies have used 18F-FDG PET/CT to examine the changes in vascular inflammation. This study investigated the changes in the inflammatory activity in the carotid artery after renal transplantation in patients with chronic kidney disease (CKD). MATERIAL AND METHODS 18F-FDG PET/CT was performed before and at 4 months after transplantation...
June 15, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29902463/reno-protective-effects-of-tak-242-on-acute-kidney-injury-in-a-rat-model
#20
Bassim I Mohammad, Abdulla K Rahem, Najah R Hadi, Dina A Jamil, Hayder A Al-Aubaidy
Acute kidney inschemia/reperfusion (I/R) injury is characterized by an abrupt loss of kidney function, resulting in the retention of urea and other nitrogenous waste products and in the dysregulation of extracellular volume and electrolytes. Despite the advances in therapeutic techniques, the mortality and morbidity of patients remain high and have not appreciably improved. This study aims to evaluate the potential protective effect of TAK-242 on renal ischemia/reperfusion injury using an animal model. Thirty-five adult male Sprague-dawely rats (weighing 200-300), were assigned randomly into the following experimental groups (n = 7 in each group), Control (I/R), Sham (negative control), TAK-242 (5 mg/kg body weight), TAK-242 (10 mg/kg body weight) and Vehicle (DMSO)...
June 11, 2018: Biochemical and Biophysical Research Communications
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