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Neurology Resident

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https://www.readbyqxmd.com/read/28431368/correlates-of-perceived-stigma-for-people-living-with-epilepsy-a-meta-analysis
#1
REVIEW
Ying Shi, Shouqi Wang, Jie Ying, Meiling Zhang, Pengcheng Liu, Huanhuan Zhang, Jiao Sun
OBJECTIVE: Epilepsy, one of the most common, serious chronic neurological diseases, is accompanied by different levels of perceived stigma that affects people in almost all age groups. This stigma can negatively impact the physical and mental health of people living with epilepsy (PLWE). Good knowledge of perceived stigma for PLWE is important. In this study, we conducted a meta-analysis to identify the correlates of perceived stigma for PLWE. METHODS: Studies on factors associated with perceived stigma for PLWE, including sociodemographic, psychosocial, and disease-related variables, were searched in PubMed, PsychINFO, EMBASE, and Web of Science...
April 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28411405/biomarkers-of-chronic-fluoride-exposure-in-groundwater-in-a-highly-exposed-population
#2
Tewodros Rango, Avner Vengosh, Marc Jeuland, Gary M Whitford, Redda Tekle-Haimanot
This study examined the relation between fluoride (F(-)) concentrations in fingernail clippings and urine and the prevalence and severity of enamel fluorosis (EF) among Ethiopian Rift Valley populations exposed to high levels of F(-) in drinking water. The utility of fingernail clippings as a biomarker for F(-) exposure and EF was also assessed for the first time in a high-F(-) region. The study recorded the EF status of 386 individuals (10 to 50years old), who consume naturally contaminated groundwater with widely varying F(-) concentration (0...
April 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28411355/rabies-acquired-through-kidney-transplantation-in-a-child-a-case-report
#3
Bassam Saeed, Mustafa Al-Mousawi
Rabies is usually transmitted to humans through bites of infected animals; however, it can rarely be transmitted through deceased donor organs or tissues when not suspected. Here, we report a case of rabies transmission in a child. The child was a 5-year-old girl who was admitted to the pediatric intensive care unit with encephalitis of unexplained cause 3.5 months after she received a kidney transplant from a deceased donor. The laboratory and imaging studies did not reveal any explanation for her rapidly declining clinical and neurologic condition, which ended with death 4 days after admission...
April 14, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28396703/characteristics-and-incidence-of-traumatic-brain-injury-in-older-adults-using-home-care-in-ontario-from-2003-2013
#4
Connor McGuire, Vicki L Kristman, Lynn Martin, Michel Bédard
OBJECTIVES: Describe the characteristics and determine the annual cumulative incidence of traumatic brain injury (TBI) in older adults receiving home care in Ontario from 2003 to 2013. METHODS: A retrospective cohort study of longitudinal data from the Ontario Association of Community Care Access Centers (N = 554,313). TBI, demographic variables, depression, neurological conditions, and recent falls were measured from the Resident Assessment Instrument-Home Care...
March 2017: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/28396459/opinion-and-special-articles-loan-forgiveness-options-for-young-neurologists-current-landscape-and-practice-implications
#5
Benjamin P George, E Ray Dorsey, Justin A Grischkan
Increasing education debt has led to the availability of a variety of loan forgiveness options including the Department of Education's Public Service Loan Forgiveness (PSLF) program. This article discusses the current landscape of loan forgiveness options including trends in PSLF for rising neurology trainees, and implications for choices in specialization, employment, practice location, and the pursuit of an academic career. We further provide guidance on how to navigate the various loan forgiveness options that neurology residents and fellows may consider...
April 11, 2017: Neurology
https://www.readbyqxmd.com/read/28382611/parkinsonism-or-other-movement-disorders-presenting-as-stroke-mimics
#6
Cheng-Yang Hsieh, Chih-Hung Chen, Sheng-Feng Sung, Wen-Juh Hwang
PURPOSE: Patients with parkinsonism or other movement disorders may visit the emergency department due to acute deterioration of neurological status or consciousness disturbance. Under such circumstances, patients may be misdiagnosed as having a hyperacute stroke, i.e. stroke mimic. The purpose of the present study was to explore the clinical features and consequences of patients with parkinsonism or other movement disorders presenting as stroke mimics with activation of a stroke code...
December 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/28368531/academic-productivity-of-us-neurosurgery-residents-as-measured-by-h-index-program-ranking-with-correlation-to-faculty-productivity
#7
Christopher A Sarkiss, Kyle J Riley, Christopher M Hernandez, Eric K Oermann, Travis R Ladner, Joshua B Bederson, Raj K Shrivastava
Engagement in research and academic productivity are crucial components in the training of a neurosurgeon. This process typically begins in residency training. In this study, we analyzed individual resident productivity as it correlated to publications across all Accreditation Council for Graduate Medical Education (ACGME)-accredited neurosurgery training programs in an attempt to identify how programs have developed and fostered a research culture and environment. We obtained a list of current neurosurgery residents in ACGME-accredited programs from the American Association of Neurological Surgeons database...
March 29, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28351945/caveolin-1-mediated-internalization-of-the-vitamin-c-transporter-svct2-in-microglia-triggers-an-inflammatory-phenotype
#8
Camila C Portugal, Renato Socodato, Teresa Canedo, Cátia M Silva, Tânia Martins, Vivian S M Coreixas, Erick C Loiola, Burkhard Gess, Dominik Röhr, Ana R Santiago, Peter Young, Richard D Minshall, Roberto Paes-de-Carvalho, António F Ambrósio, João B Relvas
Vitamin C is essential for the development and function of the central nervous system (CNS). The plasma membrane sodium-vitamin C cotransporter 2 (SVCT2) is the primary mediator of vitamin C uptake in neurons. SVCT2 specifically transports ascorbate, the reduced form of vitamin C, which acts as a reducing agent. We demonstrated that ascorbate uptake through SVCT2 was critical for the homeostasis of microglia, the resident myeloid cells of the CNS that are essential for proper functioning of the nervous tissue...
March 28, 2017: Science Signaling
https://www.readbyqxmd.com/read/28341583/a-story-of-birth-and-death-insights-into-the-formation-and-dynamics-of-the-microglial-population
#9
REVIEW
Katharine Askew, Diego Gomez-Nicola
Microglia are the main resident immunocompetent cells of the brain with key roles in brain development, homeostasis and function. Here we briefly review our current knowledge of the homeostatic mechanisms regulating the composition and turnover of the microglial population under physiological conditions from development to ageing. A greater understanding of these mechanisms may inform understanding of how dysregulation of microglial dynamics could contribute to the pathogenesis and/or progression of neurological disorders...
March 21, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28340102/impact-of-unrestricted-access-to-pregabalin-on-the-use-of-opioids-and-other-cns-active-medications-a-cross-sectional-time-series-analysis
#10
Herman Kwok, Wayne Khuu, Kimberly Fernandes, Diana Martins, Mina Tadrous, Samantha Singh, David N Juurlink, Tara Gomes
Objective. : Access to pregabalin via Ontario's public drug insurance program was expanded to an unrestricted model on April 1, 2013, from a prior authorization model. This study aims to identify the effect of expanded access on the rate of pregabalin use by publicly insured persons and to assess the characteristics of new patients initiating pregabalin following this expanded access. Methods. : We conducted a cross-sectional time series analysis using the linked health administrative records of residents of Ontario, Canada, with public drug coverage who were dispensed a prescription for pregabalin between April 1, 2006, and December 31, 2014...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28327094/finger-tapping-impairments-are-highly-sensitive-for-evaluating-upper-motor-neuron-lesions
#11
Afsaneh Shirani, Braeden D Newton, Darin T Okuda
BACKGROUND: Identifying highly sensitive and reliable neurological exam components are crucial in recognizing clinical deficiencies. This study aimed to investigate finger tapping performance differences between patients with CNS demyelinating lesions and healthy control subjects. METHODS: Twenty-three patients with multiple sclerosis or clinically isolated syndrome with infratentorial and/or cervical cord lesions on MRI, and 12 healthy controls were videotaped while tapping the tip of the index finger against the tip and distal crease of the thumb using both the dominant and non-dominant hand...
March 21, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28303920/the-golgi-protein-acbd3-facilitates-enterovirus-71-replication-by-interacting-with-3a
#12
Xiaobo Lei, Xia Xiao, Zhenzhen Zhang, Yijie Ma, Jianli Qi, Chao Wu, Yan Xiao, Zhuo Zhou, Bin He, Jianwei Wang
Enterovirus 71 (EV71) is a human pathogen that causes hand, foot, mouth disease and neurological complications. Although EV71, as well as other enteroviruses, initiates a remodeling of intracellular membrane for genomic replication, the regulatory mechanism remains elusive. By screening human cDNA library, we uncover that the Golgi resident protein acyl-coenzyme A binding domain-containing 3 (ACBD3) serves as a target of the 3A protein of EV71. This interaction occurs in cells expressing 3A or infected with EV71...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28300322/astroglia-as-a-cellular-target-for-neuroprotection-and-treatment-of-neuro-psychiatric-disorders
#13
REVIEW
Beihui Liu, Anja G Teschemacher, Sergey Kasparov
Astrocytes are key homeostatic cells of the central nervous system. They cooperate with neurons at several levels, including ion and water homeostasis, chemical signal transmission, blood flow regulation, immune and oxidative stress defense, supply of metabolites and neurogenesis. Astroglia is also important for viability and maturation of stem-cell derived neurons. Neurons critically depend on intrinsic protective and supportive properties of astrocytes. Conversely, all forms of pathogenic stimuli which disturb astrocytic functions compromise neuronal functionality and viability...
March 16, 2017: Glia
https://www.readbyqxmd.com/read/28291057/mild-cognitive-impairment-and-exposure-to-general-anesthesia-for-surgeries-and-procedures-a-population-based-case-control-study
#14
Juraj Sprung, Rosebud O Roberts, David S Knopman, Lauren L Price, Hunter P Schulz, Christie L Tatsuyama, Toby N Weingarten, Darrell R Schroeder, Andrew C Hanson, Ronald C Petersen, David O Warner
BACKGROUND: To examine whether exposure to general anesthesia for procedures at age ≥40 years is associated with prevalent mild cognitive impairment (MCI) in the elderly. METHODS: A case-control study nested within a population-based cohort. Olmsted County, Minnesota, residents, aged 70-91 years, underwent baseline evaluations that included the Clinical Dementia Rating scale, a neurologic evaluation, and neuropsychologic testing. Individuals identified with MCI (cases) at enrollment were matched 1:2 on age, sex, education, and apolipoprotein genotype with participants who were cognitively normal at the time of the index visit...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28290467/long-term-survival-after-traumatic-spinal-cord-injury-a-70-year-british-study
#15
G Savic, M J DeVivo, H L Frankel, M A Jamous, B M Soni, S Charlifue
STUDY DESIGN: Retrospective and prospective observational. OBJECTIVES: Analyse long-term survival after traumatic spinal cord injury (SCI) in Great Britain over the 70-year study period, identify mortality risk factors and estimate current life expectancy. SETTING: Two spinal centres in Great Britain. METHODS: The sample consisted of patients with traumatic SCI injured 1943-2010 who survived the first year post-injury, had residual neurological deficit on discharge and were British residents...
March 14, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28274986/use-of-simulation-training-to-prepare-pharmacy-residents-for-medical-emergencies
#16
Melissa L Thompson Bastin, Aaron M Cook, Alexander H Flannery
PURPOSE: The use of high-fidelity simulation training for preparing pharmacy residents for various high-stress and high-impact medical emergencies and the impact of this training on pharmacy residents' perception of preparedness are described. SUMMARY: During the 2015-16 residency year at the University of Kentucky Medical Center, simulation training, in addition to lecture-based orientation training, was chosen as a method to reinforce skills and knowledge learned throughout the orientation, before residents began working on-call shifts...
March 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28264141/neuroanatomy-education-the-impact-on-perceptions-attitudes-and-knowledge-of-an-intensive-course-on-general-practice-residents
#17
Mavilde Arantes, Joselina Maria Barbosa, Maria Amélia Ferreira
General practitioners are responsible for the management of an increasing number of patients with neurological illness, and thus a solid education in neurosciences is a necessary component of their training. This study examines the effects of an intensive clinical neuroanatomy course on twenty general practice residents' perceptions, attitudes, and knowledge. A knowledge test was completed by the participants and by a control group at four different time points. The participants were asked to answer a questionnaire about their reasons for signing up for the course and their attitudes and perceptions toward the course experience...
March 6, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28255460/the-polarization-states-of-microglia-in-tbi-a-new-paradigm-for-pharmacological-intervention
#18
REVIEW
Hangzhe Xu, Zhijiang Wang, Jianru Li, Haijian Wu, Yucong Peng, Linfeng Fan, Jingyin Chen, Chi Gu, Feng Yan, Lin Wang, Gao Chen
Traumatic brain injury (TBI) is a serious medical and social problem worldwide. Because of the complex pathophysiological mechanisms of TBI, effective pharmacotherapy is still lacking. The microglial cells are resident tissue macrophages located in the brain and have two major polarization states, M1 phenotype and M2 phenotype, when activated. The M1 phenotype is related to the release of proinflammatory cytokines and secondary brain injury, while the M2 phenotype has been proved to be responsible for the release of anti-inflammation cytokines and for central nervous system (CNS) repair...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28253233/differentiation-of-human-and-murine-induced-pluripotent-stem-cells-to-microglia-like-cells
#19
Hetal Pandya, Michael J Shen, David M Ichikawa, Andrea B Sedlock, Yong Choi, Kory R Johnson, Gloria Kim, Mason A Brown, Abdel G Elkahloun, Dragan Maric, Colin L Sweeney, Selamawit Gossa, Harry L Malech, Dorian B McGavern, John K Park
Microglia are resident inflammatory cells of the CNS and have important roles in development, homeostasis and a variety of neurologic and psychiatric diseases. Difficulties in procuring human microglia have limited their study and hampered the clinical translation of microglia-based treatments shown to be effective in animal disease models. Here we report the differentiation of human induced pluripotent stem cells (iPSC) into microglia-like cells by exposure to defined factors and co-culture with astrocytes...
March 2, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28243343/spanish-version-of-the-national-institutes-of-health-stroke-scale-awareness-and-use-in-united-states-a-survey-study
#20
Enrique Villalobos, Scott R Barnes, Ihtesham A Qureshi, Salvador Cruz-Flores, Alberto Maud, Gustavo J Rodriguez
OBJECTIVE: To investigate the awareness and the use of Spanish version of National Institutes of Health Stroke Scale (NIHSS) throughout the United States (US) by regions using a web-based survey. METHODS: A survey targeting physicians from two specialties that regularly manage acute stroke patients was conducted from February to August of 2015. Academic centers from the Accreditation Council for Graduate Medical Education online directory belonging to emergency medicine (EM) and neurology residency programs were identified...
January 2017: Journal of Vascular and Interventional Neurology
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