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https://www.readbyqxmd.com/read/28075435/cardiac-biomarkers-predict-1-year-mortality-in-elderly-patients-undergoing-hip-fracture-surgery
#1
Spyridon Katsanos, Andreas F Mavrogenis, Nikolaos Kafkas, Celestino Sardu, Vasileios Kamperidis, Panagiota Katsanou, Dimitrios Farmakis, John Parissis
This prospective study included 152 elderly patients (mean age, 80 years; range, 72-88 years) with a hip fracture treated surgically. Comorbidities were evaluated, and B-type natriuretic peptide was measured at baseline and at postoperative days 4 and 5 in addition to troponin I. Major cardiac events were recorded, and 1-year mortality was assessed. Comorbidity models with the important multivariate predictors of 1-year mortality were analyzed. Overall, 9 patients (6%) experienced major cardiac events postoperatively during their hospitalization...
January 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/28056485/evidence-of-invasive-and-non-invasive-treatment-modalities-for-hypertrophic-scars-a-systematic-review
#2
Mona Kafka, Vanessa Collins, Lars-Peter Kamolz, Thomas Rappl, Ludwik K Branski, Paul Wurzer
Currently, there are various therapeutic approaches to reduce hypertrophic scarring, however, there is no standard evidence-based treatment protocol. Hence, we performed a systematic review to obtain a summary of the latest clinical trials to evaluate evidence for the treatment of hypertrophic scars. The review protocol was registered and approved by PROSPERO (CRD42015027040). PubMed and Web of Science were searched using predefined MeSH-Terms to identify studies published within the last 10 years regarding treatment for hypertrophic scars...
January 5, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28035867/clinical-response-to-golimumab-in-rheumatoid-arthritis-patients-who-were-receiving-etanercept-or-adalimumab-results-of-a-multicenter-active-treatment-study
#3
Joseph E Huffstutter, Shelly Kafka, Lawrence H Brent, Marco Matucci-Cerinic, Kezhen L Tang, Marc Chevrier, Trev Sprabery, Raphael J DeHoratius
OBJECTIVE: Evaluate the efficacy and safety of subcutaneous (SC) golimumab+methotrexate (MTX) in patients with active rheumatoid arthritis (RA) despite etanercept+MTX or adalimumab+MTX therapy and evaluate whether intravenous (IV) golimumab could rescue patients who were nonresponders to SC golimumab. METHODS: In this multicenter, assessor-blinded, active-switch study of RA patients (n = 433) with inadequate response to etanercept or adalimumab +MTX, patients continued MTX and received open-label SC golimumab 50mg q4weeks through week12...
December 30, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27993687/a-literary-approach-to-tuberculosis-lessons-learned-from-anton-chekhov-franz-kafka-and-katherine-mansfield
#4
REVIEW
Cristina Vilaplana
Letters by notable writers from the past century can provide valuable information on the times in which they lived. In this article, attention is drawn to the lessons learned from three famous writers who died of tuberculosis: Anton Chekhov, Franz Kafka, and Katherine Mansfield. The characteristics of the course of the disease in the pre-antibiotic era and the importance of addressing mental health in the management of tuberculosis are discussed.
December 16, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27958528/few-cycle-pulse-laser-induced-damage-threshold-determination-of-ultra-broadband-optics
#5
Kyle R P Kafka, Noah Talisa, Gabriel Tempea, Drake R Austin, Catalin Neacsu, Enam A Chowdhury
A systematic study of few-cycle pulse laser induced damage threshold (LIDT) determination was performed for commercially-available ultra-broadband optics, (i.e. chirped mirrors, silver mirrors, beamsplitters, etc.) in vacuum and in air, for single and multi-pulse regime (S-on-1). Multi-pulse damage morphology at fluences below the single-pulse LIDT was studied in order to investigate the mechanisms leading to the onset of damage. Stark morphological contrast was observed between multi-pulse damage sites formed in air versus those in vacuum...
December 12, 2016: Optics Express
https://www.readbyqxmd.com/read/27956775/relationship-between-hepcidin-and-oxidant-antioxidant-status-in-calves-with-suspected-neonatal-septicemia
#6
E E Erkilic, H M Erdogan, M Ogun, A H Kirmizigul, E Gokce, M Kuru, A Kukurt
AIM: This study has been conducted for the purpose of determining serum hepcidin, total antioxidant status (TAS), total oxidant status (TOS), and Fe levels in calves with suspected neonatal septicemia before and after treatment and the clinical significance of hepcidin in calves with suspected neonatal septicemia. MATERIALS AND METHODS: The study material consisted of 15 calves of different ages and sexes brought to the Training, Research and Application Center at the Kafkas University Faculty of Veterinary Medicine with suspected neonatal septicemia...
November 2016: Veterinary World
https://www.readbyqxmd.com/read/27923352/genome-survey-of-pistachio-pistacia-vera-l-by-next-generation-sequencing-development-of-novel-ssr-markers-and-genetic-diversity-in-pistacia-species
#7
Elmira Ziya Motalebipour, Salih Kafkas, Mortaza Khodaeiaminjan, Nergiz Çoban, Hatice Gözel
BACKGROUND: Pistachio (Pistacia vera L.) is one of the most important nut crops in the world. There are about 11 wild species in the genus Pistacia, and they have importance as rootstock seed sources for cultivated P. vera and forest trees. Published information on the pistachio genome is limited. Therefore, a genome survey is necessary to obtain knowledge on the genome structure of pistachio by next generation sequencing. Simple sequence repeat (SSR) markers are useful tools for germplasm characterization, genetic diversity analysis, and genetic linkage mapping, and may help to elucidate genetic relationships among pistachio cultivars and species...
December 7, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27899665/open-targets-a-platform-for-therapeutic-target-identification-and-validation
#8
Gautier Koscielny, Peter An, Denise Carvalho-Silva, Jennifer A Cham, Luca Fumis, Rippa Gasparyan, Samiul Hasan, Nikiforos Karamanis, Michael Maguire, Eliseo Papa, Andrea Pierleoni, Miguel Pignatelli, Theo Platt, Francis Rowland, Priyanka Wankar, A Patrícia Bento, Tony Burdett, Antonio Fabregat, Simon Forbes, Anna Gaulton, Cristina Yenyxe Gonzalez, Henning Hermjakob, Anne Hersey, Steven Jupe, Şenay Kafkas, Maria Keays, Catherine Leroy, Francisco-Javier Lopez, Maria Paula Magarinos, James Malone, Johanna McEntyre, Alfonso Munoz-Pomer Fuentes, Claire O'Donovan, Irene Papatheodorou, Helen Parkinson, Barbara Palka, Justin Paschall, Robert Petryszak, Naruemon Pratanwanich, Sirarat Sarntivijal, Gary Saunders, Konstantinos Sidiropoulos, Thomas Smith, Zbyslaw Sondka, Oliver Stegle, Y Amy Tang, Edward Turner, Brendan Vaughan, Olga Vrousgou, Xavier Watkins, Maria-Jesus Martin, Philippe Sanseau, Jessica Vamathevan, Ewan Birney, Jeffrey Barrett, Ian Dunham
We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27859925/material-specificity-drives-medial-temporal-lobe-familiarity-but-not-hippocampal-recollection
#9
Alex Kafkas, Ellen M Migo, Robin G Morris, Michael D Kopelman, Daniela Montaldi, Andrew R Mayes
The specific role of the perirhinal (PRC), entorhinal (ERC) and parahippocampal cortices (PHC) in supporting familiarity-based recognition remains unknown. An fMRI study explored whether these medial temporal lobe (MTL) structures responded in the same way or differentially to familiarity as a function of stimulus type at recognition. A secondary aim was to explore whether the hippocampus responds in the same way to equally strong familiarity and recollection and whether this is influenced by the kind of stimulus involved...
November 16, 2016: Hippocampus
https://www.readbyqxmd.com/read/27826973/chronic-hypoxia-increases-fetoplacental-vascular-resistance-in-rat-placenta-perfused-with-blood
#10
P Kafka, O Vajnerova, V Hampl
BACKGROUND: Chronic hypoxia elevates vascular resistance on the fetal side of the placenta. However, when a low-viscosity perfusate is used, the increase in resistance caused by chronic hypoxia is relatively small (12 mmHg). In the present study, we tested the hypothesis that perfusion with more viscous fluid (blood) will reveal more substantial effect of chronic hypoxia. METHODS: Using an isolated, dually perfused rat placenta perfused at a constant flow rate with homologous blood, perfusion pressure on the fetal side was measured...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27787977/synthesis-of-1-4-benzodiazepine-2-5-diones-by-base-promoted-ring-expansion-of-3-aminoquinoline-2-4-diones
#11
Filip Křemen, Martin Gazvoda, Stanislav Kafka, Karel Proisl, Anna Srholcová, Antonin Klasek, Damijana Urankar, Janez Košmrlj
An unprecedented reactivity of 3-aminoquinoline-2,4-diones is reported. Under basic conditions these compounds undergo molecular rearrangement to furnish 1,4-benzodiazepine-2,5-diones. The transformations take place under mild reaction conditions by using 1,1,3,3-tetramethylguanidine (TMG), NaOEt, or benzyltrimethylammonium hydroxide (Triton B) as a base. A proposed mechanism of the rearrangement and the conformational equilibrium of 1,4-benzodiazepine-2,5-dione rings are discussed.
October 27, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27768356/limits-on-active-to-sterile-neutrino-oscillations-from-disappearance-searches-in-the-minos-daya-bay-and-bugey-3-experiments
#12
P Adamson, F P An, I Anghel, A Aurisano, A B Balantekin, H R Band, G Barr, M Bishai, A Blake, S Blyth, G J Bock, D Bogert, D Cao, G F Cao, J Cao, S V Cao, T J Carroll, C M Castromonte, W R Cen, Y L Chan, J F Chang, L C Chang, Y Chang, H S Chen, Q Y Chen, R Chen, S M Chen, Y Chen, Y X Chen, J Cheng, J-H Cheng, Y P Cheng, Z K Cheng, J J Cherwinka, S Childress, M C Chu, A Chukanov, J A B Coelho, L Corwin, D Cronin-Hennessy, J P Cummings, J de Arcos, S De Rijck, Z Y Deng, A V Devan, N E Devenish, X F Ding, Y Y Ding, M V Diwan, M Dolgareva, J Dove, D A Dwyer, W R Edwards, C O Escobar, J J Evans, E Falk, G J Feldman, W Flanagan, M V Frohne, M Gabrielyan, H R Gallagher, S Germani, R Gill, R A Gomes, M Gonchar, G H Gong, H Gong, M C Goodman, P Gouffon, N Graf, R Gran, M Grassi, K Grzelak, W Q Gu, M Y Guan, L Guo, R P Guo, X H Guo, Z Guo, A Habig, R W Hackenburg, S R Hahn, R Han, S Hans, J Hartnell, R Hatcher, M He, K M Heeger, Y K Heng, A Higuera, A Holin, Y K Hor, Y B Hsiung, B Z Hu, T Hu, W Hu, E C Huang, H X Huang, J Huang, X T Huang, P Huber, W Huo, G Hussain, J Hylen, G M Irwin, Z Isvan, D E Jaffe, P Jaffke, C James, K L Jen, D Jensen, S Jetter, X L Ji, X P Ji, J B Jiao, R A Johnson, J K de Jong, J Joshi, T Kafka, L Kang, S M S Kasahara, S H Kettell, S Kohn, G Koizumi, M Kordosky, M Kramer, A Kreymer, K K Kwan, M W Kwok, T Kwok, K Lang, T J Langford, K Lau, L Lebanowski, J Lee, J H C Lee, R T Lei, R Leitner, J K C Leung, C Li, D J Li, F Li, G S Li, Q J Li, S Li, S C Li, W D Li, X N Li, Y F Li, Z B Li, H Liang, C J Lin, G L Lin, S Lin, S K Lin, Y-C Lin, J J Ling, J M Link, P J Litchfield, L Littenberg, B R Littlejohn, D W Liu, J C Liu, J L Liu, C W Loh, C Lu, H Q Lu, J S Lu, P Lucas, K B Luk, Z Lv, Q M Ma, X B Ma, X Y Ma, Y Q Ma, Y Malyshkin, W A Mann, M L Marshak, D A Martinez Caicedo, N Mayer, K T McDonald, C McGivern, R D McKeown, M M Medeiros, R Mehdiyev, J R Meier, M D Messier, W H Miller, S R Mishra, I Mitchell, M Mooney, C D Moore, L Mualem, J Musser, Y Nakajima, D Naples, J Napolitano, D Naumov, E Naumova, J K Nelson, H B Newman, H Y Ngai, R J Nichol, Z Ning, J A Nowak, J O'Connor, J P Ochoa-Ricoux, A Olshevskiy, M Orchanian, R B Pahlka, J Paley, H-R Pan, J Park, R B Patterson, S Patton, G Pawloski, V Pec, J C Peng, A Perch, M M Pfützner, D D Phan, S Phan-Budd, L Pinsky, R K Plunkett, N Poonthottathil, C S J Pun, F Z Qi, M Qi, X Qian, X Qiu, A Radovic, N Raper, B Rebel, J Ren, C Rosenfeld, R Rosero, B Roskovec, X C Ruan, H A Rubin, P Sail, M C Sanchez, J Schneps, A Schreckenberger, P Schreiner, R Sharma, S Moed Sher, A Sousa, H Steiner, G X Sun, J L Sun, N Tagg, R L Talaga, W Tang, D Taychenachev, J Thomas, M A Thomson, X Tian, A Timmons, J Todd, S C Tognini, R Toner, D Torretta, K Treskov, K V Tsang, C E Tull, G Tzanakos, J Urheim, P Vahle, N Viaux, B Viren, V Vorobel, C H Wang, M Wang, N Y Wang, R G Wang, W Wang, X Wang, Y F Wang, Z Wang, Z M Wang, R C Webb, A Weber, H Y Wei, L J Wen, K Whisnant, C White, L Whitehead, L H Whitehead, T Wise, S G Wojcicki, H L H Wong, S C F Wong, E Worcester, C-H Wu, Q Wu, W J Wu, D M Xia, J K Xia, Z Z Xing, J L Xu, J Y Xu, Y Xu, T Xue, C G Yang, H Yang, L Yang, M S Yang, M T Yang, M Ye, Z Ye, M Yeh, B L Young, Z Y Yu, S Zeng, L Zhan, C Zhang, H H Zhang, J W Zhang, Q M Zhang, X T Zhang, Y M Zhang, Y X Zhang, Z J Zhang, Z P Zhang, Z Y Zhang, J Zhao, Q W Zhao, Y B Zhao, W L Zhong, L Zhou, N Zhou, H L Zhuang, J H Zou
Searches for a light sterile neutrino have been performed independently by the MINOS and the Daya Bay experiments using the muon (anti)neutrino and electron antineutrino disappearance channels, respectively. In this Letter, results from both experiments are combined with those from the Bugey-3 reactor neutrino experiment to constrain oscillations into light sterile neutrinos. The three experiments are sensitive to complementary regions of parameter space, enabling the combined analysis to probe regions allowed by the Liquid Scintillator Neutrino Detector (LSND) and MiniBooNE experiments in a minimally extended four-neutrino flavor framework...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27768323/search-for-sterile-neutrinos-mixing-with-muon-neutrinos-in-minos
#13
P Adamson, I Anghel, A Aurisano, G Barr, M Bishai, A Blake, G J Bock, D Bogert, S V Cao, T J Carroll, C M Castromonte, R Chen, S Childress, J A B Coelho, L Corwin, D Cronin-Hennessy, J K de Jong, S De Rijck, A V Devan, N E Devenish, M V Diwan, C O Escobar, J J Evans, E Falk, G J Feldman, W Flanagan, M V Frohne, M Gabrielyan, H R Gallagher, S Germani, R A Gomes, M C Goodman, P Gouffon, N Graf, R Gran, K Grzelak, A Habig, S R Hahn, J Hartnell, R Hatcher, A Holin, J Huang, J Hylen, G M Irwin, Z Isvan, C James, D Jensen, T Kafka, S M S Kasahara, G Koizumi, M Kordosky, A Kreymer, K Lang, J Ling, P J Litchfield, P Lucas, W A Mann, M L Marshak, N Mayer, C McGivern, M M Medeiros, R Mehdiyev, J R Meier, M D Messier, W H Miller, S R Mishra, S Moed Sher, C D Moore, L Mualem, J Musser, D Naples, J K Nelson, H B Newman, R J Nichol, J A Nowak, J O'Connor, M Orchanian, R B Pahlka, J Paley, R B Patterson, G Pawloski, A Perch, M M Pfützner, D D Phan, S Phan-Budd, R K Plunkett, N Poonthottathil, X Qiu, A Radovic, B Rebel, C Rosenfeld, H A Rubin, P Sail, M C Sanchez, J Schneps, A Schreckenberger, P Schreiner, R Sharma, A Sousa, N Tagg, R L Talaga, J Thomas, M A Thomson, X Tian, A Timmons, J Todd, S C Tognini, R Toner, D Torretta, G Tzanakos, J Urheim, P Vahle, B Viren, A Weber, R C Webb, C White, L Whitehead, L H Whitehead, S G Wojcicki, R Zwaska
We report results of a search for oscillations involving a light sterile neutrino over distances of 1.04 and 735 km in a ν_{μ}-dominated beam with a peak energy of 3 GeV. The data, from an exposure of 10.56×10^{20} protons on target, are analyzed using a phenomenological model with one sterile neutrino. We constrain the mixing parameters θ_{24} and Δm_{41}^{2} and set limits on parameters of the four-dimensional Pontecorvo-Maki-Nakagawa-Sakata matrix, |U_{μ4}|^{2} and |U_{τ4}|^{2}, under the assumption that mixing between ν_{e} and ν_{s} is negligible (|U_{e4}|^{2}=0)...
October 7, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27630299/axin1-expression-and-localization-in-meningiomas-and-association-to-changes-of-apc-and-e-cadherin
#14
Nives Pećina-Šlaus, Anja Kafka, Tomislav Vladušić, Hrvoje Ivan Pećina, Reno Hrašćan
BACKGROUND/AIM: Tumor suppressor gene AXIN1 is an inhibitor of Wnt signaling pathway. It down-regulates the pathway's main signaling effector molecule, beta-catenin, in an AXIN-based destruction complex. In the present study we investigated the involvement of AXIN1 in intracranial meningioma. MATERIALS AND METHODS: Loss of heterozygosity and microsatellite instability analyses were performed. The consequences of genetic changes on protein expression levels were studied in the same patients by immunohistochemistry...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27571153/franz-kafka-s-insomnia-and-parasomnias
#15
Antonio Perciaccante, Alessia Coralli
No abstract text is available yet for this article.
September 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27540220/assessing-pharmaceutical-care-needs-of-paediatric-in-patients-a-team-based-approach
#16
Adele Mott, Susan Kafka, Adam Sutherland
AIMS: To pilot a novel approach to providing pharmaceutical care to paediatric inpatients using structured referral and assessment tools. Using standardised referral criteria to ensure patients are assessed by appropriately skilled pharmacists. METHOD: Three wards of varying acuity and specialism were selected in a tertiary children's hospital in England - General Paediatric Ward (GPW), High Dependency Unit (HDU) and Haematology/Oncology Ward (HOW). The project ran for three months...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27429642/antimicrobials-a-global-alliance-for-optimizing-their-rational-use-in-intra-abdominal-infections-agora
#17
REVIEW
Massimo Sartelli, Dieter G Weber, Etienne Ruppé, Matteo Bassetti, Brian J Wright, Luca Ansaloni, Fausto Catena, Federico Coccolini, Fikri M Abu-Zidan, Raul Coimbra, Ernest E Moore, Frederick A Moore, Ronald V Maier, Jan J De Waele, Andrew W Kirkpatrick, Ewen A Griffiths, Christian Eckmann, Adrian J Brink, John E Mazuski, Addison K May, Rob G Sawyer, Dominik Mertz, Philippe Montravers, Anand Kumar, Jason A Roberts, Jean-Louis Vincent, Richard R Watkins, Warren Lowman, Brad Spellberg, Iain J Abbott, Abdulrashid Kayode Adesunkanmi, Sara Al-Dahir, Majdi N Al-Hasan, Ferdinando Agresta, Asma A Althani, Shamshul Ansari, Rashid Ansumana, Goran Augustin, Miklosh Bala, Zsolt J Balogh, Oussama Baraket, Aneel Bhangu, Marcelo A Beltrán, Michael Bernhard, Walter L Biffl, Marja A Boermeester, Stephen M Brecher, Jill R Cherry-Bukowiec, Otmar R Buyne, Miguel A Cainzos, Kelly A Cairns, Adrian Camacho-Ortiz, Sujith J Chandy, Asri Che Jusoh, Alain Chichom-Mefire, Caroline Colijn, Francesco Corcione, Yunfeng Cui, Daniel Curcio, Samir Delibegovic, Zaza Demetrashvili, Belinda De Simone, Sameer Dhingra, José J Diaz, Isidoro Di Carlo, Angel Dillip, Salomone Di Saverio, Michael P Doyle, Gereltuya Dorj, Agron Dogjani, Hervé Dupont, Soumitra R Eachempati, Mushira Abdulaziz Enani, Valery N Egiev, Mutasim M Elmangory, Paula Ferrada, Joseph R Fitchett, Gustavo P Fraga, Nathalie Guessennd, Helen Giamarellou, Wagih Ghnnam, George Gkiokas, Staphanie R Goldberg, Carlos Augusto Gomes, Harumi Gomi, Manuel Guzmán-Blanco, Mainul Haque, Sonja Hansen, Andreas Hecker, Wolfgang R Heizmann, Torsten Herzog, Adrien Montcho Hodonou, Suk-Kyung Hong, Reinhold Kafka-Ritsch, Lewis J Kaplan, Garima Kapoor, Aleksandar Karamarkovic, Martin G Kees, Jakub Kenig, Ronald Kiguba, Peter K Kim, Yoram Kluger, Vladimir Khokha, Kaoru Koike, Kenneth Y Y Kok, Victory Kong, Matthew C Knox, Kenji Inaba, Arda Isik, Katia Iskandar, Rao R Ivatury, Maurizio Labbate, Francesco M Labricciosa, Pierre-François Laterre, Rifat Latifi, Jae Gil Lee, Young Ran Lee, Marc Leone, Ari Leppaniemi, Yousheng Li, Stephen Y Liang, Tonny Loho, Marc Maegele, Sydney Malama, Hany E Marei, Ignacio Martin-Loeches, Sanjay Marwah, Amos Massele, Michael McFarlane, Renato Bessa Melo, Ionut Negoi, David P Nicolau, Carl Erik Nord, Richard Ofori-Asenso, AbdelKarim H Omari, Carlos A Ordonez, Mouaqit Ouadii, Gerson Alves Pereira Júnior, Diego Piazza, Guntars Pupelis, Timothy Miles Rawson, Miran Rems, Sandro Rizoli, Claudio Rocha, Boris Sakakhushev, Miguel Sanchez-Garcia, Norio Sato, Helmut A Segovia Lohse, Gabriele Sganga, Boonying Siribumrungwong, Vishal G Shelat, Kjetil Soreide, Rodolfo Soto, Peep Talving, Jonathan V Tilsed, Jean-Francois Timsit, Gabriel Trueba, Ngo Tat Trung, Jan Ulrych, Harry van Goor, Andras Vereczkei, Ravinder S Vohra, Imtiaz Wani, Waldemar Uhl, Yonghong Xiao, Kuo-Ching Yuan, Sanoop K Zachariah, Jean-Ralph Zahar, Tanya L Zakrison, Antonio Corcione, Rita M Melotti, Claudio Viscoli, Perluigi Viale
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance...
2016: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/27429002/molecular-genetics-of-intracranial-meningiomas-with-emphasis-on-canonical-wnt-signalling
#18
REVIEW
Nives Pećina-Šlaus, Anja Kafka, Mirna Lechpammer
Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins in this common brain tumour, describing their known functional effects. Meningiomas originate from the meningeal layers of the brain and the spinal cord. Most meningiomas have benign clinical behaviour and are classified as grade I by World Health Organization (WHO)...
2016: Cancers
https://www.readbyqxmd.com/read/27383814/effect-of-triclosan-coated-suture-and-antibiotic-prophylaxis-on-infection-and-recurrence-after-karydakis-flap-repair-for-pilonidal-disease-a-randomized-parallel-arm-double-blinded-clinical-trial
#19
Aziz Bora Karip, Kafkas Çelik, Timuçin Aydın, Hanife Yazıcılar, Yalın İşcan, Canan Ağalar, Kemal Memişoğlu
BACKGROUND: Pilonidal sinus disease was first described by Mayo in 1833 as "a cyst that contains hair." Although surgical treatment of the lesions can have successful outcomes, it also can be associated with relatively high rates of post-operative infectioins and recurrence. Many studies have demonstrated that triclosan-coated sutures (TCS) decrease surgical site infections. OBJECTIVE: The goal of this randomized parallel-arm double-blind clinical trial was to investigate the ability of antibiotic prophylaxis, and secondarily of antibiotic-coated sutures, to prevent post-operative infections in the surgical management of pilonidal sinus disease...
October 2016: Surgical Infections
https://www.readbyqxmd.com/read/27292269/loss-of-p53-expression-is-accompanied-by-upregulation-of-beta-catenin-in-meningiomas-a-concomitant-reciprocal-expression
#20
Nives Pećina-Šlaus, Anja Kafka, Tomislav Vladušić, Davor Tomas, Monika Logara, Josip Skoko, Reno Hrašćan
Crosstalk between Wnt and p53 signalling pathways in cancer has long been suggested. Therefore in this study we have investigated the involvement of these pathways in meningiomas by analysing their main effector molecules, beta-catenin and p53. Cellular expression of p53 and beta-catenin proteins and genetic changes in TP53 were analysed by immunohistochemistry, PCR/RFLP and direct sequencing of TP53 exon 4. All the findings were analysed statistically. Our analysis showed that 47.5% of the 59 meningiomas demonstrated loss of expression of p53 protein...
April 2016: International Journal of Experimental Pathology
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