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https://www.readbyqxmd.com/read/29609088/milrinone-associated-cardiomyopathy-and-arrhythmia-in-cerebral-vasospasm
#1
Eva M Wu, Tarek Y El Ahmadieh, Benjamin Kafka, Matthew T Davies, Salah G Aoun, Jonathan A White
BACKGROUND: Milrinone is an inotropic and vasodilatory drug proven safe for use in the treatment of cerebral vasospasm. Despite its reported safety profile, its use is not free of side effects. Milrinone-associated cardiomyopathy and arrhythmia can occur in patients with cerebral vasospasm. CASE DESCRIPTION: This is a retrospective chart review of a patient who presented with aneurysmal subarachnoid hemorrhage and developed clinical vasospasm twice over a period of two weeks...
March 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29553138/interferon-%C3%AE-induced-in-female-genital-epithelium-by-hiv-1-glycoprotein-120-via-toll-like-receptor-2-pathway-acts-to-protect-the-mucosal-barrier
#2
Aisha Nazli, Sara Dizzell, Muhammad Atif Zahoor, Victor H Ferreira, Jessica Kafka, Matthew William Woods, Michel Ouellet, Ali A Ashkar, Michel J Tremblay, Dawn Me Bowdish, Charu Kaushic
More than 40% of HIV infections occur via female reproductive tract (FRT) through heterosexual transmission. Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens. These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses. Previously, we have shown that in response to HIV-1 gp120, the genital epithelial cells (GECs) from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection...
March 19, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29543261/enhanced-laser-conditioning-using-temporally-shaped-pulses
#3
K R P Kafka, S Papernov, S G Demos
Laser conditioning was investigated as a function of the temporal shape and duration of 351 nm nanosecond pulses for fused-silica substrates polished via magnetorheological finishing. The aim is to advance our understanding of the dynamics involved to enable improved control of the interaction of laser light with the material to optimize laser conditioning. Gaussian pulses that are temporally truncated at the intensity peak are observed to enhance laser conditioning, in comparison to a Gaussian pulse shape...
March 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29525901/perianal-minimally-invasive-surgery-pamis-for-rectal-stump-resection-after-previous-colectomy
#4
Andreas Lorenz, Pamela Kogler, Marcus Huth, Reinhold Kafka-Ritsch, Dietmar Öfner, Alexander Perathoner
PURPOSE: Resection of a long rectal stump after previous colectomy or Hartmann procedure often requires a combined transperitoneal and transperineal approach because of limited access through a perineal incision alone. Risks associated with this procedure include iatrogenic injury to bowels, nerves, ureters, vessels and sexual organs. This study reports on the feasibility and safety of perianal minimally invasive surgery (PAMIS) for the resection of long rectal stumps that would otherwise require a combined transperitoneal and perianal approach...
March 10, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29522762/bidirectional-regulation-of-hdac5-by-makap%C3%AE-signalosomes-in-cardiac-myocytes
#5
Kimberly L Dodge-Kafka, Moriah Gildart, Jinliang Li, Hrishikesh Thakur, Michael S Kapiloff
Class IIa histone deacetylases (HDACs) are transcriptional repressors whose nuclear export in the cardiac myocyte is associated with the induction of pathological gene expression and cardiac remodeling. Class IIa HDACs are regulated by multiple, functionally opposing post-translational modifications, including phosphorylation by protein kinase D (PKD) that promotes nuclear export and phosphorylation by protein kinase A (PKA) that promotes nuclear import. We have previously shown that the scaffold protein muscle A-kinase anchoring protein β (mAKAPβ) orchestrates signaling in the cardiac myocyte required for pathological cardiac remodeling, including serving as a scaffold for both PKD and PKA...
March 6, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29504410/prevention-of-radial-artery-occlusions-following-coronary-procedures-forward-and-backward-steps-in-improving-radial-artery-patency-rates
#6
George Hahalis, Grigorios Tsigkas, Nikos Kounis, Sotirios Patsilinakos, Nikolaos Kafkas, Antonios Ziakas, Nikolaos Patsourakos, George Almpanis, Ioanna Koniari, Ioanna Xanthopoulou, Nikolaos Koutsogiannis, Stefanos Despotopoulos, Marianna Leopoulou, Vasiliky Tassi, Ioannis Miliordos, Maria Anastasopoulou, Anastasios Roumeliotis, Athina Dapergola, Konstantinos Aznaouridis, Dimitrios Chatzis, Periklis Davlouros
Radial artery (RA) occlusion (RAO) remains the Achilles heel of transradial coronary procedures. Although of silent nature, RAO is relatively frequent, results in graft shortage for future coronary artery bypass surgery, and may occur even after short-lasting, 5F coronary angiography (CAG). The most frequent predictors of RAO are RA size, body size, female gender, and periprocedural anticoagulation intensity. Methods to detect RAO are variable, of which the Barbeau test and ultrasonography have similar diagnostic accuracy...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29486854/pregestational-diabetes-increases-fetoplacental-vascular-resistance-in-rats
#7
Olga Vajnerova, Petr Kafka, Tereza Kratzerova, Karel Chalupsky, Vaclav Hampl
INTRODUCTION: Diabetes is a well-known risk factor in pregnancy. Because maternal diabetes involves oxidative stress that is also induced by chronic hypoxia and can alter vascular function, we sought to determine the effects of chronic maternal hyperglycemia on the fetoplacental vasculature in rats and to compare it with the effects of chronic hypoxia. METHODS: Diabetes was induced in female rats by a streptozotocin injection at a neonatal age. When these animals reached adulthood, their hyperglycemia was confirmed and they were inseminated...
March 2018: Placenta
https://www.readbyqxmd.com/read/29429109/behaviour-and-risk-assessment-of-fluopyram-and-its-metabolite-in-cucumber-cucumis-sativus-fruit-and-in-soil
#8
Suchi Chawla, Dilip J Patel, Sunny R Patel, Ravi L Kalasariya, Paresh G Shah
A field experiment was conducted to estimate residue persistence of fluopyram and its metabolite benzamide in cucumber fruits and soil and their risk assessment in humans and soil environment. Fluopyram (Kafka, 400 SC) was applied as soil drench twice at the interval of 15 days at the rate of 250 (standard dose) and 500 (double dose) g a.i. ha-1 (active ingredient per hectare). Cucumber fruits were collected at 0 (1 h), 1, 3, 5, 7, 10, 15, 20, 30, 40 and 50 days after second application. Soil samples were collected on 15th day after second application...
February 10, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29408218/how-do-memory-systems-detect-and-respond-to-novelty
#9
REVIEW
Alex Kafkas, Daniela Montaldi
The efficiency of the memory system lies not only in its readiness to detect and retrieve old stimuli but also in its ability to detect and integrate novel information. In this review, we discuss recent evidence suggesting that the neural substrates sensitive to detecting familiarity and novelty are not entirely overlapping. Instead, these partially distinct familiarity and novelty signals are integrated to support recognition memory decisions. We propose here that the mediodorsal thalamus is critical for familiarity detection, and for combining novelty signals from the medial temporal lobe cortex with the relative familiarity outputs of computations performed in other cortical structures, especially the prefrontal cortex...
February 2, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29399061/neuroprotective-effect-of-local-hypothermia-in-a-computer-controlled-compression-model-in-minipig-correlation-of-tissue-sparing-along-the-rostro-caudal-axis-with-neurological-outcome
#10
Stefania Gedrova, Jan Galik, Martin Marsala, Monika Zavodska, Jaroslav Pavel, Igor Sulla, Miroslav Gajdos, Imrich Lukac, Jozef Kafka, Valent Ledecky, Igor Sulla, Martina Karasova, Peter Reichel, Alexandra Trbolova, Igor Capik, Viktoria Lukacova, Katarina Bimbova, Maria Bacova, Andrea Stropkovska, Nadezda Lukacova
This study investigated the neuroprotective efficacy of local hypothermia in a minipig model of spinal cord injury (SCI) induced by a computer-controlled impactor device. The tissue integrity observed at the injury epicenter, and up to 3 cm cranially and caudally from the lesion site correlated with motor function. A computer-controlled device produced contusion lesions at L3 level with two different degrees of tissue sparing, depending upon pre-set impact parameters (8N- and 15N-force impact). Hypothermia with cold (4°C) saline or Dulbecco's modified Eagle's medium (DMEM)/F12 culture medium was applied 30 min after SCI (for 5 h) via a perfusion chamber (flow 2 ml/min)...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29374579/radial-artery-as-coronary-artery-bypass-graft-in-the-era-of-transradial-catheterization
#11
REVIEW
Stylianos Dragasis, Nikolaos Kafkas, Charalampos I Liakos
Radial artery use as a bypass conduit is well established during the last decades, in terms of both patency and safety. On the other hand, transradial catheterization causes a series of structural and functional changes to the vessel itself. Impairment of nitric oxide-dependent vasodilation and notable decrease on radial artery diameter due to intima thickening and hyperplasia, especially during the first 3 months after its cannulation, constitute some of the most important alterations on the radial artery wall and its function after a transradial coronary catheterization procedure...
January 25, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29363016/cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-a-single-center-experience-in-austria
#12
Kogler Pamela, Zitt Matthias, Kafka-Ritsch Reinhold, Punter Julia, Müssigang Peter, Perathoner Alexander, Öfner Dietmar
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) can significantly influence overall and disease-free survival in selected patients suffering from peritoneal surface malignancies (PSM) of various tumor entities. Because of the extent of the therapeutic approach, the associated morbidity and mortality and the multidisciplinarity needed, implementation of a CRS + HIPEC program at an institution is often challenging. METHODS: This single-center analysis included all patients (n = 60, 34 female, 26 male) with PSM from various tumor primaries [colorectal cancer (15/60; 25%), appendix neoplasia (21/60; 35%), and others (24/60; 40%)] treated with CRS + HIPEC at our institution between 2006 and 2014...
January 23, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29322912/usage-of-cell-nomenclature-in-biomedical-literature
#13
Şenay Kafkas, Sirarat Sarntivijai, Robert Hoehndorf
BACKGROUND: Cell lines and cell types are extensively studied in biomedical research yielding to a significant amount of publications each year. Identifying cell lines and cell types precisely in publications is crucial for science reproducibility and knowledge integration. There are efforts for standardisation of the cell nomenclature based on ontology development to support FAIR principles of the cell knowledge. However, it is important to analyse the usage of cell nomenclature in publications at a large scale for understanding the level of uptake of cell nomenclature in literature by scientists...
December 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29321514/flavin-reductase-contributes-to-pneumococcal-virulence-by-protecting-from-oxidative-stress-and-mediating-adhesion-and-elicits-protection-against-pneumococcal-challenge
#14
Giora I Morozov, Nurith Porat, Tatyana Kushnir, Hastyar Najmuldeen, Asad Adawi, Vered Chalifa-Caspi, Rachel Benisty, Ariel Ohayon, Ofir Liron, Shalhevet Azriel, Itai Malka, Shahar Dotan, Maxim Portnoi, Andrew A Piotrowski, Daniel Kafka, Barak Hajaj, Tali Fishilevich, Marilou Shagan, Michael Tal, Ron Ellis, Donald A Morrison, Andrea M Mitchell, Timothy J Mitchell, Ron Dagan, Hasan Yesilkaya, Yaffa Mizrachi Nebenzahl
Pneumococcal flavin reductase (FlaR) is known to be cell-wall associated and possess age dependent antigenicity in children. This study aimed at characterizing FlaR and elucidating its involvement in pneumococcal physiology and virulence. Bioinformatic analysis of FlaR sequence identified three-conserved cysteine residues, suggesting a transition metal-binding capacity. Recombinant FlaR (rFlaR) bound Fe2+ and exhibited FAD-dependent NADP-reductase activity, which increased in the presence of cysteine or excess Fe2+ and inhibited by divalent-chelating agents...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29200599/expression-levels-and-localizations-of-dvl3-and-sfrp3-in-glioblastoma
#15
Anja Kafka, Davor Tomas, Mirna Lechpammer, Tea Gabud, Leo Pažanin, Nives Pećina-Šlaus
The expression patterns of critical molecular components of Wnt signaling, sFRP3 and DVL3, were investigated in glioblastoma, the most aggressive form of primary brain tumors, with the aim to offer potential biomarkers. The protein expression levels and localizations in tumor tissue were revealed by immunohistochemistry and evaluated by the semiquantitative method and immunoreactivity score. Majority of glioblastomas had moderate expression levels for both DVL3 (52.4%) and sFRP3 (52.3%). Strong expression levels were observed in 23...
2017: Disease Markers
https://www.readbyqxmd.com/read/28979103/patient-reported-outcome-assessment-of-inflammatory-arthritis-patient-experience-with-intravenously-administered-biologic-therapy
#16
Norman B Gaylis, Joanne Sagliani, Shawn Black, Kezhen L Tang, Raphael DeHoratius, Wesley A Kafka, Dennis Parenti
OBJECTIVE: To evaluate patient perspectives regarding utilization of intravenous (IV) therapy for inflammatory arthritis (IA). METHODS: This was a single-center, noninterventional, patient questionnaire-based study of adult IA patients currently receiving IV biologics. At a single visit, patients completed the questionnaire comprising 30 questions centered on their experience receiving an intravenously administered therapy to treat their IA. The questionnaire included questions on patient demographics, disease characteristics, and previous biologic treatment for IA (subcutaneous [SC] and IV)...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28957187/high-order-harmonic-generations-in-intense-mir-fields-by-cascade-three-wave-mixing-in-a-fractal-poled-linbo-3-photonic-crystal
#17
Hyunwook Park, Antoine Camper, Kyle Kafka, Boqin Ma, Yu Hang Lai, Cosmin Blaga, Pierre Agostini, Louis F DiMauro, Enam Chowdhury
We report on the generation of harmonic-like photon upconversion in a LiNbO3 -based nonlinear photonic crystal by mid-infrared (MIR) femtosecond laser pulses. We study below bandgap harmonics of various driver wavelengths, reaching up to the 11th order at 4 μm driver with 13% efficiency. We compare our results to numerical simulations based on two mechanisms: cascade three-wave mixing and non-perturbative harmonic generation, both of which include quasi-phase matching. The cascade model reproduces well the general features of the observed spectrum, including a plateau-like harmonic distribution and the observed efficiency...
October 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28748430/inicu-integrated-neonatal-care-unit-capturing-neonatal-journey-in-an-intelligent-data-way
#18
Harpreet Singh, Gautam Yadav, Raghuram Mallaiah, Preetha Joshi, Vinay Joshi, Ravneet Kaur, Suneyna Bansal, Samir K Brahmachari
Neonatal period represents first 28 days of life, which is the most vulnerable time for a child's survival especially for the preterm babies. High neonatal mortality is a prominent and persistent problem across the globe. Non-availability of trained staff and infrastructure are the major recognized hurdles in the quality care of these neonates. Hourly progress growth charts and reports are still maintained manually by nurses along with continuous calculation of drug dosage and nutrition as per the changing weight of the baby...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28729269/multiple-genome-sequences-of-lactobacillus-plantarum-strains
#19
Thomas A Kafka, Andreas J Geissler, Rudi F Vogel
We report here the genome sequences of four Lactobacillus plantarum strains which vary in surface hydrophobicity. Bioinformatic analysis, using additional genomes of Lactobacillus plantarum strains, revealed a possible correlation between the cell wall teichoic acid-type and cell surface hydrophobicity and provide the basis for consecutive analyses.
July 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28705114/genetic-changes-of-mlh1-and-msh2-genes-could-explain-constant-findings-on-microsatellite-instability-in-intracranial-meningioma
#20
Nives Pećina-Šlaus, Anja Kafka, Anja Bukovac, Tomislav Vladušić, Davor Tomas, Reno Hrašćan
Postreplicative mismatch repair safeguards the stability of our genome. The defects in its functioning will give rise to microsatellite instability. In this study, 50 meningiomas were investigated for microsatellite instability. Two major mismatch repair genes, MLH1 and MSH2, were analyzed using microsatellite markers D1S1611 and BAT26 amplified by polymerase chain reaction and visualized by gel electrophoresis on high-resolution gels. Furthermore, genes DVL3 (D3S1262), AXIN1 (D16S3399), and CDH1 (D16S752) were also investigated for microsatellite instability...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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