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https://www.readbyqxmd.com/read/28715161/schedules-of-controlled-substances-temporary-placement-of-acryl-fentanyl-into-schedule-i-temporary-scheduling-order
#1
(no author information available yet)
The Administrator of the Drug Enforcement Administration is issuing this temporary scheduling order to schedule the synthetic opioid, N-(1-phenethylpiperidin-4-yl)-N-phenylacrylamide (acryl fentanyl or acryloylfentanyl), and its isomers, esters, ethers, salts and salts of isomers, esters, and ethers, into Schedule I. This action is based on a finding by the Administrator that the placement of acryl fentanyl into Schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety...
July 14, 2017: Federal Register
https://www.readbyqxmd.com/read/28713432/haematological-profile-and-intensity-of-urogenital-schistosomiasis-in-ghanaian-children
#2
Justice Afrifa, Desmond Gyedu, Eric Ofori Gyamerah, Samuel Essien-Baidoo, Isaac Mensah-Essilfie
BACKGROUND: Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. AIM: We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. MATERIALS AND METHODS: A total of 100 participants comprising 50 Schistosoma haematobium (S. haematobium) infected and 50 noninfected controls aged 6-17 years matched for age and sex were recruited into the study...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28713147/to-enroll-or-not-to-enroll-a-researcher-struggles-with-the-decision-to-involve-study-participants-in-a-clinical-trial-that-could-save-their-lives
#3
Roberto Abadie
Hundreds of thousands of clinical trials are conducted annually around the world, working to further scientific knowledge and expand medical treatment. At the same time, clinical trials also present novel challenges to researchers who have access to large pools of research participants and are routinely approached by pharmaceutical companies seeking to recruit subjects for clinical trials. This case study discusses the ethical dilemmas faced by a community health investigator who received an invitation to enroll people who inject drugs (PWID) into a clinical trial of a drug that promised a new treatment option for Hepatitis C...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/28709927/determining-the-distribution-of-fitness-effects-using-a-generalized-beta-burr-distribution
#4
Paul Joyce, Zaid Abdo
In Beisel et al. (2007), a likelihood framework, based on extreme value theory (EVT), was developed for determining the distribution of fitness effects for adaptive mutations. In this paper we extend this framework beyond the extreme distributions and develop a likelihood framework for testing whether or not extreme value theory applies. By making two simple adjustments to the Generalized Pareto Distribution (GPD) we introduce a new simple five parameter probability density function that incorporates nearly every common (continuous) probability model ever used...
July 12, 2017: Theoretical Population Biology
https://www.readbyqxmd.com/read/28701003/-the-impact-of-migration-background-on-health-results-of-the-austrian-health-interview-survey-athis-2014
#5
Anja Waxenegger, Hannes Mayerl, Éva Rásky, Erwin Stolz, Wolfgang Freidl
Objectives Previous research has shown migrants to have a poorer health status than those without a migration background in many respects. So far, it is not completely clear whether the poorer health results of migrants are mainly the cause of their socioeconomic status (SES), which on average is lower than the SES of people without a migration background. The present study explores the question whether the fact of having a migration background has an impact on health, even though SES and health-related behavior are taken into account...
July 12, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28690425/an-unsettled-bargain-mothers-perceptions-of-justice-and-fairness-in-paid-work
#6
Mara A Yerkes, Bill Martin, Janeen Baxter, Judy Rose
Mothers' return to work following childbirth is widely recognized as a key stage in establishing employment arrangements that disadvantage them in the long run. This article investigates why mothers accept these unequal arrangements using data from a qualitative study of 109 Australian mothers. It focuses on mothers' perceptions of the fairness and justice of the flexibility of arrangements they commonly enter into upon return to work. The article draws attention to the importance of different justice frameworks, distributive, procedural and interactional, in understanding women's acceptance of gender inequality in paid work...
June 2017: Journal of Sociology: the Journal of the Australian Sociological Association
https://www.readbyqxmd.com/read/28652920/perception-of-and-attitude-toward-ethical-issues-among-korean-occupational-physicians
#7
Junghye Choi, Chunhui Suh, Jong-Tae Lee, Segyeong Lee, Chae-Kwan Lee, Gyeong-Jin Lee, Taekjoong Kim, Byung-Chul Son, Jeong-Ho Kim, Kunhyung Kim, Dae Hwan Kim, Ji Young Ryu
BACKGROUND: Occupational physicians (OPs) have complex relationships with employees, employers, and the general public. OPs may have simultaneous obligations towards third parties, which can lead to variable conflicts of interests. Among the various studies of ethical issues related to OPs, few have focused on the Korean OPs. The aim of the present survey was to investigate the ethical contexts, the practical resolutions, and the ethical principles for the Korean OPs. METHODS: An email with a self-administered questionnaire was sent to members of the Korean Society of Occupational and Environmental Medicine, comprising 150 specialists and 130 residents...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28645979/the-2015-middle-childhood-survey-mcs-of-mental-health-and-well-being-at-age-11-years-in-an-australian-population-cohort
#8
Kristin R Laurens, Stacy Tzoumakis, Kimberlie Dean, Sally A Brinkman, Miles Bore, Rhoshel K Lenroot, Maxwell Smith, Allyson Holbrook, Kim M Robinson, Robert Stevens, Felicity Harris, Vaughan J Carr, Melissa J Green
PURPOSE: The Middle Childhood Survey (MCS) was designed as a computerised self-report assessment of children's mental health and well-being at approximately 11 years of age, conducted with a population cohort of 87 026 children being studied longitudinally within the New South Wales (NSW) Child Development Study. PARTICIPANTS: School Principals provided written consent for teachers to administer the MCS in class to year 6 students at 829 NSW schools (35.0% of eligible schools)...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28627155/-environmental-justice-in-the-epidemiological-surveillance-system-of-residents-in-italian-national-priority-contaminated-sites-sentieri-project
#9
Roberto Pasetto, Nicolás Zengarini, Nicola Caranci, Marco De Santis, Fabrizio Minichilli, Michele Santoro, Roberta Pirastu, Pietro Comba
OBJECTIVES: descriptive evaluation of distributional justice in the epidemiological surveillance system of populations residing in Italian National priority Contaminated Sites (NPCSs) of SENTIERI project. Analysis of the feasibility of monitoring different Environmental Justice dimensions in SENTIERI. DESIGN: descriptive study and ecological meta-analysis. SETTING AN PARTICIPANTS: residents in 298 municipalities included in 44 NPCSs in SENTIERI. Description of their level of deprivation and mortality analysis by deprivation level in the first period evaluated in SENTIERI, years 1995-2002...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28614350/ranking-and-characterization-of-established-bmi-and-lipid-associated-loci-as-candidates-for-gene-environment-interactions
#10
Dmitry Shungin, Wei Q Deng, Tibor V Varga, Jian'an Luan, Evelin Mihailov, Andres Metspalu, Andrew P Morris, Nita G Forouhi, Cecilia Lindgren, Patrik K E Magnusson, Nancy L Pedersen, Göran Hallmans, Audrey Y Chu, Anne E Justice, Mariaelisa Graff, Thomas W Winkler, Lynda M Rose, Claudia Langenberg, L Adrienne Cupples, Paul M Ridker, Nicholas J Wareham, Ken K Ong, Ruth J F Loos, Daniel I Chasman, Erik Ingelsson, Tuomas O Kilpeläinen, Robert A Scott, Reedik Mägi, Guillaume Paré, Paul W Franks
Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic effects (Pm). Correlations between Pv and Pm were stronger for SNPs with established marginal effects (Spearman's ρ = 0...
June 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28600041/lessons-from-the-mohw-compensation-pilot-program-on-birth-incidents-first-step-and-looking-forward
#11
Tsung-Hsi Wang, Shu-Fen Lin, Kun-Yu Tsai, Yu-Fu Liu
OBJECTIVE: In Taiwan, the number of medical disputes and litigation has increased dramatically over the past 20 years. The seriousness of medical disputes continuing grows in clinical practice, especially in obstetricians. This study provided a possible solution to the medical dispute litigation issue. MATERIALS AND METHODS: The Ministry of Health and Welfare (MOHW) compensation program for birth incidents has been implemented since 2012 and it provided pecuniary compensation for mothers, newborns, and fetuses who got injured or died in birth-related medical incidents...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28591974/schedules-of-controlled-substances-placement-of-acetyl-fentanyl-into-schedule-i-final-order
#12
(no author information available yet)
With the issuance of this final order, the Administrator of the Drug Enforcement Administration will maintain the placement of the substance acetyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide), including its isomers, esters, ethers, salts, and salts of isomers, esters and ethers, in schedule I of the Controlled Substances Act. This scheduling action is pursuant to the Controlled Substances Act and is required in order for the United States to discharge its obligations under the Single Convention on Narcotic Drugs, 1961...
June 7, 2017: Federal Register
https://www.readbyqxmd.com/read/28591187/male-suicide-rates-in-german-prisons-and-the-role-of-citizenship
#13
Daniel Radeloff, Thomas Lempp, Mattias Kettner, Amna Rauf, Katharina Bennefeld-Kersten, Christine M Freitag
PURPOSE: Prisoners are at a particularly high risk of suicide. In contrast to other psychosocial risk factors it remains unclear to what degree the risk of suicide differs between prisoners with local citizenship and foreigners. In order to provide more detailed information for suicide prevention in prisons, this study aims to compare suicide rates (SR) between these populations in German criminal custody. METHODS: Based on a German national database of completed suicide in custody, suicides by prisoners were analysed and compared with epidemiological data of the prison population and the general population, stratified for German and foreign citizenship...
2017: PloS One
https://www.readbyqxmd.com/read/28578075/from-evidence-based-to-hope-based-medicine-ethical-aspects-on-conditional-market-authorization-of-and-early-access-to-new-cancer-drugs
#14
REVIEW
Lars Sandman, Jan Liliemark
There is a strong patient demand for early access to potentially beneficial cancer drugs. In line with this authorization agencies like the European Medicines Agency are providing drugs with conditional market authorisation based on positive interim analyses. This implies that drugs are used with insecure evidence of efficacy and adverse side-effects. Several authors have pointed to ethical problems with such a system but up to date no indepth ethical analysis of this system is found which is the aim of this article...
May 31, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28550158/viewing-benefit-sharing-in-global-health-research-through-the-lens-of-aristotelian-justice
#15
REVIEW
Bege Dauda, Kris Dierickx
The ethics of benefit sharing has been a topical issue in global health research in resource-limited countries. It pertains to the distribution of goods, benefits and advantages to the research participants, communities and countries that are involved in research. One of the nuances in benefit sharing is the ethical justification on which the concept should be based. Extensive literature outlining the different principles underlying benefit sharing is available. The purpose of this paper is to examine the proposed principles using Aristotelian principles of justice...
June 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28549542/study-of-autosomal-str-loci-with-ibs-method-in-full-sibling-identification
#16
Li Yuan, Xu Xu, Dong Zhao, He Ren, Chaohui Hu, Wen Chen, Shicheng Hao, Di Lu, Lin Zhang
OBJECTIVE: We investigated the application of 51 autosomal short tandem repeat (STR) loci with the identity by state (IBS) method and a discriminant function algorithm in full-sib identification. METHODS: A total of 342 pairs of full sibs (FSs) and 3900 pairs of unrelated individuals (UIs) were genotyped for 51 STR loci. Groups were formed in accordance with discrimination power (DP) values and the number of loci, and IBS scores of FSs and UIs were analyzed and compared...
May 2017: Legal Medicine
https://www.readbyqxmd.com/read/28544136/conceptualizations-of-fairness-and-legitimacy-in-the-context-of-ethiopian-health-priority-setting-reflections-on-the-applicability-of-accountability-for-reasonableness
#17
Kadia Petricca, Asfaw Bekele
A critical element in building stronger health systems involves strengthening good governance to build capacity for transparent and fair health planning and priority setting. Over the past 20 years, the ethical framework Accountability for Reasonableness (A4R) has been a prominent conceptual guide in strengthening fair and legitimate processes of health decision-making. While many of the principles embedded within the framework are congruent with Western conceptualizations of what constitutes procedural fairness, there is a paucity in the literature that captures the degree of resonance between these principles and the views of decision makers from non-Western settings; particularly in Africa, where many countries have only recently, within the last 20-30 years, become more democratic...
May 22, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28540441/investigating-climate-compatible-development-outcomes-and-their-implications-for-distributive-justice-evidence-from-malawi
#18
Benjamin T Wood, Claire H Quinn, Lindsay C Stringer, Andrew J Dougill
Governments and donors are investing in climate compatible development in order to reduce climate and development vulnerabilities. However, the rate at which climate compatible development is being operationalised has outpaced academic enquiry into the concept. Interventions aiming to achieve climate compatible development "wins" (for development, mitigation, adaptation) can also create negative side-effects. Moreover, benefits and negative side-effects may differ across time and space and have diverse consequences for individuals and groups...
May 24, 2017: Environmental Management
https://www.readbyqxmd.com/read/28513968/the-views-of-ethics-committee-members-and-medical-researchers-on-the-return-of-individual-research-results-and-incidental-findings-ownership-issues-and-benefit-sharing-in-biobanking-research-in-a-south-indian-city
#19
Manjulika Vaz, Mario Vaz, Srinivasan K
The return of individual research results and incidental findings from biobanking research is a much debated ethical issue globally but has extensive relevance in India where the burden of out of pocket health care expenses is high for the majority. The views of 21 ethics committee (EC) members and 22 researchers from Bengaluru, India, concerning the ethics of biobanking research were sought through in-depth interviews using an unfolding case vignette with probes. A shared view among most was that individual research results which are 'actionable' or have 'clinical significance' should be returned to the sample contributors through their treating physicians...
May 17, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28511680/cohort-profile-seek-test-treat-and-retain-united-states-criminal-justice-cohort
#20
Redonna Chandler, Michael S Gordon, Bridget Kruszka, Lauren N Strand, Frederick L Altice, Curt G Beckwith, Mary L Biggs, William Cunningham, J A Chris Delaney, Patrick M Flynn, Carol E Golin, Kevin Knight, Alex H Kral, Irene Kuo, Jennifer Lorvick, Robin M Nance, Lawrence J Ouellet, Josiah D Rich, Stanley Sacks, David Seal, Anne Spaulding, Sandra A Springer, Faye Taxman, David Wohl, Jeremy D Young, Rebekah Young, Heidi M Crane
BACKGROUND: The STTR treatment cascade provides a framework for research aimed at improving the delivery of services, care and outcomes of PLWH. The development of effective approaches to increase HIV diagnoses and engage PLWH in subsequent steps of the treatment cascade could lead to earlier and sustained ART treatment resulting in viral suppression. There is an unmet need for research applying the treatment cascade to improve outcomes for those with criminal justice involvement. METHODS: The Seek, Test, Treat, and Retain (STTR) criminal justice (CJ) cohort combines data from 11 studies across the HIV treatment cascade that focused on persons involved in the criminal justice system, often but not exclusively for reasons related to substance use...
May 16, 2017: Substance Abuse Treatment, Prevention, and Policy
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