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Farrah mateen

Leah Wibecan, Günther Fink, Lhab Tshering, Verónica Bruno, Bryan Patenaude, Damber K Nirola, Chencho Dorji, Ugyen Dema, Dillram Pokhrel, Farrah J Mateen
OBJECTIVE: To assess the economic impact of epilepsy in Bhutan, a lower-middle-income country with a universal health care system, but with limited access to neurological care. METHODS: A cross-sectional survey was conducted of patients with epilepsy at the Jigme Dorji Wangchuk National Referral Hospital from January to August, 2016. Data were collected on clinical features, cost of care, impact of epilepsy on school or work, and household economic status of participants and matched comparisons (a sibling or neighbor from a household without epilepsy)...
January 25, 2018: Tropical Medicine & International Health: TM & IH
Farrah J Mateen, Erica D McKenzie, Sherri Rose
OBJECTIVE: To report on medical schools in fragile states, countries with severe development challenges, and the impact on the workforce for health care delivery. DATA SOURCES: 2007 and 2012 World Bank Harmonized List of Fragile Situations; 1998-2012 WHO Global Health Observatory; 2014 World Directory of Medical Schools. DATA EXTRACTION: Fragile classification established from 2007 and 2012 World Bank status. Population, gross national income, health expenditure, and life expectancy were 2007 figures...
January 24, 2018: Health Services Research
Mahmoud A AbdelRazek, Jose Gutierrez, David Mampre, Anna Cervantes-Arslanian, Cora Ormseth, Diogo Haussen, Kiran T Thakur, Jennifer L Lyons, Bryan R Smith, Owen O'Connor, Joshua Z Willey, Farrah J Mateen
BACKGROUND AND PURPOSE: Human immunodeficiency virus (HIV) infection has been shown to increase both ischemic and hemorrhagic stroke risks, but there are limited data on the safety and outcomes of intravenous thrombolysis with tPA (tissue-type plasminogen activator) for acute ischemic stroke in HIV-infected patients. METHODS: A retrospective chart review of intravenous tPA-treated HIV patients who presented with acute stroke symptoms was performed in 7 large inner-city US academic centers (various search years between 2000 and 2017)...
January 2018: Stroke; a Journal of Cerebral Circulation
Veronica Bruno, Joshua P Klein, Dechen Nidup, Damber K Nirola, Lhab Tshering, Sonam Deki, Sarah J Clark, Kristin A Linn, Russell T Shinohara, Chencho Dorji, Dili Ram Pokhrel, Ugyen Dema, Farrah J Mateen
BACKGROUND: People with epilepsy (PWE) in low- and middle-income countries may not access the health resources that are considered optimal for epilepsy diagnosis. The diagnostic yield of magnetic resonance imaging (MRI) has not been well studied in these settings. OBJECTIVES: To report the diagnostic yield of brain MRI and identify clinical associations of abnormal MRI findings among PWE in a neurocysticercosis-endemic, resource-limited setting and to identify the proportion and putative structural brain causes of drug-resistant epilepsy...
May 2017: Annals of Global Health
Sheliza Halani, Lhab Tshering, Esther Bui, Sarah J Clark, Sara J Grundy, Tandin Pem, Sonam Lhamo, Ugyen Dema, Damber K Nirola, Chencho Dorji, Farrah J Mateen
INTRODUCTION: Reports on the reproductive health of women with epilepsy (WWE) in low- and middle-income countries (LMICs) are limited. Bhutan is a lower income country with a high estimated prevalence of epilepsy and no out-of-pocket payment requirements for health visits or medications. METHODS: We developed a 10-category survey to interview WWE ages 20-59 years in the Kingdom of Bhutan to understand their contraceptive use and peripartum experiences. WWE were recruited from 2016-2017 from an existing epilepsy cohort and their reproductive health data were merged with epilepsy and socioeconomic data obtained from initial clinical evaluations performed between 2014 and 2016...
December 2017: Epilepsy Research
Eric C Klawiter, Riley Bove, Liene Elsone, Enrique Alvarez, Nadja Borisow, Melissa Cortez, Farrah Mateen, Maureen A Mealy, Jaime Sorum, Kerry Mutch, Sean M Tobyne, Klemens Ruprecht, Guy Buckle, Michael Levy, Dean Wingerchuk, Friedemann Paul, Anne H Cross, Anu Jacobs, Tanuja Chitnis, Brian Weinshenker
OBJECTIVE: To study the effect of pregnancy on the frequency of neuromyelitis optica spectrum disorder (NMOSD) relapse and evaluate rates of pregnancy-related complications in an international multicenter setting. METHODS: We administered a standardized survey to 217 women with NMOSD from 7 medical centers and reviewed their medical records. We compared the annualized relapse rate (ARR) during a baseline period 2 years prior to a participant's first pregnancy to that during pregnancy and to the 9 months postpartum...
November 28, 2017: Neurology
Joel Salinas, Alexa Beiser, Jayandra J Himali, Claudia L Satizabal, Hugo J Aparicio, Galit Weinstein, Farrah J Mateen, Lisa F Berkman, Jonathan Rosand, Sudha Seshadri
INTRODUCTION: Mechanisms underlying social determinants of stroke and dementia are unclear and brain-derived neurotrophic factor (BDNF) may contribute as a molecular link. METHODS: Using the Framingham Study, we examined social relationship measures as predictors of higher serum BDNF level and cumulative incidence of stroke and dementia. RESULTS: Among 3294 participants, controlling for age and sex, isolation trended with lower BDNF (odds ratio = 0...
June 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Farrah J Mateen, Natalie C Manalo, Sara J Grundy, Melissa A Houghton, Gladia C Hotan, Hans Erickson, Aleksandar Videnovic
BACKGROUND: Fatigue is the most commonly reported symptom among multiple sclerosis (MS) patients, more than a quarter of whom consider fatigue to be their most disabling symptom. However, there are few effective treatment options for fatigue. We aim to investigate whether supplemental exposure to bright white light will reduce MS-associated fatigue. METHODS: Eligible participants will have clinically confirmed multiple sclerosis based on the revised McDonald criteria (2010) and a score ≥36 on the Fatigue Severity Scale (FSS)...
September 2017: Medicine (Baltimore)
Lindsay C Kobayashi, M Maria Glymour, Kathleen Kahn, Collin F Payne, Ryan G Wagner, Livia Montana, Farrah J Mateen, Stephen M Tollman, Lisa F Berkman
RATIONALE: Little research has evaluated the life course drivers of cognitive aging in South Africa. OBJECTIVES: We investigated the relationships of self-rated childhood health and father's occupation during childhood with later-life cognitive function score and whether educational attainment mediated these relationships among older South Africans living in a former region of Apartheid-era racial segregation. METHODS: Data were from baseline assessments of "Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community" (HAALSI), a population-based study of 5059 men and women aged ≥40 years in 2015 in rural Agincourt sub-district, South Africa...
August 14, 2017: Social Science & Medicine
Farrah J Mateen, Marco Carone, Lhab Tshering, Chencho Dorji, Ugyen Dema, Sara J Grundy, Dili Ram Pokhrel, Damber K Nirola
OBJECTIVE: The objective of this study was to report the impact of chronic abuse of Areca catechu nut wrapped in leaf (also known as doma, quid, paan), the fourth most commonly abused psychoactive substance worldwide, on the frequency of seizures among people with epilepsy. METHODS: People with clinically diagnosed epilepsy (>14years old) residing in the Kingdom of Bhutan were surveyed for self-reported Areca catechu use, demographic variables, epilepsy characteristics, and seizure frequency...
July 18, 2017: Epilepsy & Behavior: E&B
Altaf Saadi, Farrah J Mateen
Humanitarian emergencies defined by armed conflict, political strife, famine, or natural disaster can devastate populations rapidly. Neurologic disorders accompany these complex humanitarian emergencies but often go unheeded, exacerbated by a scarcity of neurologists. Teleneurology offers the promise of neurologic care remotely in the face of this inadequate local clinician supply. We describe our experiences as voluntary neurology teleconsultants with Médecins Sans Frontières in order to highlight both the promises and challenges of teleneurology in humanitarian contexts...
July 18, 2017: Neurology
Diederik L H Koelman, David C Benkeser, Joshua P Klein, Farrah J Mateen
Patients with acute disseminated encephalomyelitis (ADEM) are presumed to have radiological monophasic disease, but this is uncertain since follow-up brain MRI is not routinely performed. We aimed to ascertain combined radiological and clinical monophasic disease in ADEM patients and to assess whether performing early (<6 months) follow-up brain MRI has prognostic value for subsequent multiphasic disease. We retrospectively studied the medical records of patients initially diagnosed with ADEM (years 2000-2014) at the Massachusetts General Hospital, USA...
August 2017: Journal of Neurology
James D Berry, Sabrina Paganoni, Nazem Atassi, Eric A Macklin, Namita Goyal, Michael Rivner, Ericka Simpson, Stanley Appel, Daniela L Grasso, Nicte I Mejia, Farrah Mateen, Alan Gill, Fernando Vieira, Valerie Tassinari, Steven Perrin
INTRODUCTION: Immune activation has been implicated in progression of amytrophic lateral sclerosis (ALS). Oral fingolimod reduces circulating lymphocytes. The objective of this phase IIa, randomized, controlled trial was to test the short-term safety, tolerability, and target engagement of fingolimod in ALS. METHODS: Randomization was 2:1 (fingolimod:placebo). Treatment duration was 4 weeks. Primary outcomes were safety and tolerability. Secondary outcomes included circulating lymphocytes and whole-blood gene expression...
December 2017: Muscle & Nerve
Farrah J Mateen, Maria Grau-Perez, Jonathan S Pollak, Katherine A Moon, Barbara V Howard, Jason G Umans, Lyle G Best, Kevin A Francesconi, Walter Goessler, Ciprian Crainiceanu, Eliseo Guallar, Richard B Devereux, Mary J Roman, Ana Navas-Acien
BACKGROUND: Inorganic arsenic exposure from naturally contaminated groundwater is related to vascular disease. No prospective studies have evaluated the association between arsenic and carotid atherosclerosis at low-moderate levels. We examined the association of long-term, low-moderate inorganic arsenic exposure with carotid arterial disease. METHODS: American Indians, 45-74 years old, in Arizona, Oklahoma, and North and South Dakota had arsenic concentrations (sum of inorganic and methylated species, μg/g urine creatinine) measured from baseline urine samples (1989-1991)...
August 2017: Environmental Research
Riley Bove, Liene Elsone, Enrique Alvarez, Nadja Borisow, Melissa M Cortez, Farrah J Mateen, Maureen A Mealy, Kerry Mutch, Sean Tobyne, Klemens Ruprecht, Guy Buckle, Michael Levy, Dean M Wingerchuk, Friedemann Paul, Anne H Cross, Brian Weinshenker, Anu Jacob, Eric C Klawiter, Tanuja Chitnis
OBJECTIVE: To study the association between hormonal exposures and disease onset in a cohort of women with neuromyelitis optica spectrum disorder (NMOSD). METHODS: Reproductive history and hormone use were assessed using a standardized reproductive survey administered to women with NMOSD (82% aquaporin-4 antibody positive) at 8 clinical centers. Using multivariable regression, we examined the association between reproductive exposures and age at first symptom onset (FS)...
May 2017: Neurology® Neuroimmunology & Neuroinflammation
Erica D McKenzie, Andrew S P Lim, Edward C W Leung, Andrew J Cole, Alice D Lam, Ani Eloyan, Damber K Nirola, Lhab Tshering, Ronald Thibert, Rodrigo Zepeda Garcia, Esther Bui, Sonam Deki, Liesly Lee, Sarah J Clark, Joseph M Cohen, Jo Mantia, Kate T Brizzi, Tali R Sorets, Sarah Wahlster, Mia Borzello, Arkadiusz Stopczynski, Sydney S Cash, Farrah J Mateen
Our objective was to assess the ability of a smartphone-based electroencephalography (EEG) application, the Smartphone Brain Scanner-2 (SBS2), to detect epileptiform abnormalities compared to standard clinical EEG. The SBS2 system consists of an Android tablet wirelessly connected to a 14-electrode EasyCap headset (cost ~ 300 USD). SBS2 and standard EEG were performed in people with suspected epilepsy in Bhutan (2014-2015), and recordings were interpreted by neurologists. Among 205 participants (54% female, median age 24 years), epileptiform discharges were detected on 14% of SBS2 and 25% of standard EEGs...
April 3, 2017: Scientific Reports
Don Gilden, Diederik L H Koelman, Farrah J Mateen
No abstract text is available yet for this article.
November 15, 2016: Neurology
Kate Brizzi, Sonam Pelden, Tshokey Tshokey, Damber K Nirola, Megan B Diamond, Joshua P Klein, Lhab Tshering, Sonam Deki, Dechen Nidup, Veronica Bruno, Pierre Dorny, Hector Hugo Garcia, Farrah J Mateen
BACKGROUND: We sought to provide an assessment of the burden of neurocysticercosis among people with epilepsy (PWE) in Bhutan and evaluate the yield of various tests for Taenia solium. METHODS: PWE were enrolled at the National Referral Hospital in Thimphu (2014-2015). Serum was tested for anti-Taenia solium IgG using ELISA (Ab-ELISA), enzyme-linked immunoelectrotransfer blot (EITB), and parasite antigen. Results were compared to brain MRI. Participants were categorized as definite neurocysticercosis (MRI and EITB positive), probable neurocysticercosis (MRI or EITB positive), or without neurocysticercosis...
September 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
Altaf Saadi, Bryan Patenaude, Damber Kumar Nirola, Sonam Deki, Lhab Tshering, Sarah Clark, Lance Shaull, Tali Sorets, Guenther Fink, Farrah Mateen
No abstract text is available yet for this article.
November 2016: Seizure: the Journal of the British Epilepsy Association
Altaf Saadi, Bryan Patenaude, Damber Kumar Nirola, Sonam Deki, Lhab Tshering, Sarah Clark, Lance Shaull, Tali Sorets, Guenther Fink, Farrah Mateen
PURPOSE: To assess the quality of life in epilepsy (QOLIE) among adults in the lower middle-income country of Bhutan and assess the potential demographic and clinical associations with better QOLIE. METHODS: People with clinically diagnosed epilepsy were prospectively enrolled at the Jigme Dorji Wangchuck National Referral Hospital in Thimphu (2014-2015). Regression models were constructed to assess the potential impact of age, sex, residence in the capital city, wealth quintile, educational attainment, seizure in the prior year, seizures with loss of consciousness, self-reported stigma score, and need for multiple antiepileptic drugs...
July 2016: Seizure: the Journal of the British Epilepsy Association
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