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https://www.readbyqxmd.com/read/28548508/possible-dark-matter-annihilation-signal-in-the-ams-02-antiproton-data
#1
Ming-Yang Cui, Qiang Yuan, Yue-Lin Sming Tsai, Yi-Zhong Fan
Using the latest AMS-02 cosmic-ray antiproton flux data, we search for a potential dark matter annihilation signal. The background parameters about the propagation, source injection, and solar modulation are not assumed a priori but based on the results inferred from the recent B/C ratio and proton data measurements instead. The possible dark matter signal is incorporated into the model self-consistently under a Bayesian framework. Compared with the astrophysical background-only hypothesis, we find that a dark matter signal is favored...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28545048/a-distribution-model-of-functional-connectome-based-on-criticality-and-energy-constraints
#2
Kosuke Takagi
The analysis of the network structure of the functional connectivity data constructed from fMRI images provides basic information about functions and features of the brain activity. We focus on the two features which are considered as relevant to the brain activity, the criticality and the constraint regarding energy consumptions. Within a wide variety of complex systems, the critical state occurs associated with a phase transition between distinct phases, random one and order one. Although the hypothesis that human brain activity is also in a state of criticality is supported by some experimental results, it still remains controversial...
2017: PloS One
https://www.readbyqxmd.com/read/28541207/an-efficient-fusion-based-defogging
#3
Jing-Ming Guo, Jin-Yu Syue, Vincent Radzicki, Hua Lee
Degradation in visibility is often introduced to images captured in poor weather conditions, such as fog or haze. To overcome this problem, conventional approaches focus mainly on the enhancement of the overall image contrast. However, because of the unspecified light-source distribution or unsuitable mathematical constraints of the cost functions, it is often difficult to achieve quality results. In this paper, a fusion-based transmission estimation method is introduced to adaptively combine two different transmission models...
May 19, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28539924/therapeutic-development-of-mesenchymal-stem-cells-or-their-extracellular-vesicles-to-inhibit-autoimmune-mediated-inflammatory-processes-in-systemic-lupus-erythematosus
#4
REVIEW
Juhi Sharma, Jeffrey M Hampton, Giancarlo R Valiente, Takuma Wada, Holly Steigelman, Matthew C Young, Rachel R Spurbeck, Alisa D Blazek, Steffi Bösh, Wael N Jarjour, Nicholas A Young
Since being discovered over half a century ago, mesenchymal stem cells (MSCs) have been investigated extensively to characterize their cellular and physiological influences. MSCs have been shown to possess immunosuppressive capacity through inhibiting lymphocyte activation/proliferation and proinflammatory cytokine secretion while simultaneously demonstrating limited allogenic reactivity, which subsequently led to the evaluation of therapeutic feasibility to treat inflammatory diseases. Although regulatory constraints have restricted MSC development pharmacologically, limited clinical studies have shown encouraging results using MSC infusions to treat systemic lupus erythematosus (SLE); but, more trials will have to be performed to conclusively determine the clinical efficacy of MSCs to treat SLE...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28538188/identification-and-characterization-of-a-class-of-malat1-like-genomic-loci
#5
Bin Zhang, Yuntao S Mao, Sarah D Diermeier, Irina V Novikova, Eric P Nawrocki, Tom A Jones, Zsolt Lazar, Chang-Shung Tung, Weijun Luo, Sean R Eddy, Karissa Y Sanbonmatsu, David L Spector
The MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) gene encodes a noncoding RNA that is processed into a long nuclear retained transcript (MALAT1) and a small cytoplasmic tRNA-like transcript (mascRNA). Using an RNA sequence- and structure-based covariance model, we identified more than 130 genomic loci in vertebrate genomes containing the MALAT1 3' end triple-helix structure and its immediate downstream tRNA-like structure, including 44 in the green lizard Anolis carolinensis. Structural and computational analyses revealed a co-occurrence of components of the 3' end module...
May 23, 2017: Cell Reports
https://www.readbyqxmd.com/read/28535056/solid-state-nmr-structure-based-inhibitor-design-to-achieve-selective-inhibition-of-the-parallel-in-register-%C3%AE-sheet-versus-antiparallel-iowa-mutant-%C3%AE-amyloid-fibrils
#6
Qinghui Cheng, Wei Qiang
Solid-state nuclear magnetic resonance (ssNMR) spectroscopy has been widely applied to characterize the high-resolution structures of β-amyloid (Aβ) fibrils. While these structures provide crucial molecular insights on the deposition of amyloid plaques in Alzheimer's diseases (AD), ssNMR structures have been rarely used so far as basis for designing inhibitors. It remains a challenge because the ssNMR-based Aβ fibrils structures were usually obtained with sparsely-isotope-labeled peptides with limited experimental constraints, where the structural models, especially the side-chain coordinates showed restricted precision...
May 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28532500/extending-access-to-essential-services-against-constraints-the-three-tier-health-service-delivery-system-in-rural-china-1949-1980
#7
Xing Lin Feng, Melisa Martinez-Alvarez, Jun Zhong, Jin Xu, Beibei Yuan, Qingyue Meng, Dina Balabanova
BACKGROUND: China has made remarkable progress in scaling up essential services during the last six decades, making health care increasingly available in rural areas. This was partly achieved through the building of a three-tier health system in the 1950s, established as a linked network with health service facilities at county, township and village level, to extend services to the whole population. METHODS: We developed a Theory of Change to chart the policy context, contents and mechanisms that may have facilitated the establishment of the three-tier health service delivery system in rural China...
May 23, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28531226/intercenter-validation-of-a-knowledge-based-model-for-automated-planning-of-volumetric-modulated-arc-therapy-for-prostate-cancer-the-experience-of-the-german-rapidplan-consortium
#8
Carolin Schubert, Oliver Waletzko, Christian Weiss, Dirk Voelzke, Sevda Toperim, Arnd Roeser, Silvia Puccini, Marc Piroth, Christian Mehrens, Jan-Dirk Kueter, Kirsten Hierholz, Karsten Gerull, Antonella Fogliata, Andreas Block, Luca Cozzi
PURPOSE: To evaluate the performance of a model-based optimisation process for volumetric modulated arc therapy applied to prostate cancer in a multicentric cooperative group. The RapidPlan (RP) knowledge-based engine was tested for the planning of Volumetric modulated arc therapy with RapidArc on prostate cancer patients. The study was conducted in the frame of the German RapidPlan Consortium (GRC). METHODS AND MATERIALS: 43 patients from one institute of the GRC were used to build and train a RP model...
2017: PloS One
https://www.readbyqxmd.com/read/28531184/bacarena-individual-based-metabolic-modeling-of-heterogeneous-microbes-in-complex-communities
#9
Eugen Bauer, Johannes Zimmermann, Federico Baldini, Ines Thiele, Christoph Kaleta
Recent advances focusing on the metabolic interactions within and between cellular populations have emphasized the importance of microbial communities for human health. Constraint-based modeling, with flux balance analysis in particular, has been established as a key approach for studying microbial metabolism, whereas individual-based modeling has been commonly used to study complex dynamics between interacting organisms. In this study, we combine both techniques into the R package BacArena (https://cran.r-project...
May 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28530728/ultrafast-coulomb-explosion-of-a-diiodomethane-molecule-induced-by-an-x-ray-free-electron-laser-pulse
#10
Tsukasa Takanashi, Kosuke Nakamura, Edwin Kukk, Koji Motomura, Hironobu Fukuzawa, Kiyonobu Nagaya, Shin-Ichi Wada, Yoshiaki Kumagai, Denys Iablonskyi, Yuta Ito, Yuta Sakakibara, Daehyun You, Toshiyuki Nishiyama, Kazuki Asa, Yuhiro Sato, Takayuki Umemoto, Kango Kariyazono, Kohei Ochiai, Manabu Kanno, Kaoru Yamazaki, Kuno Kooser, Christophe Nicolas, Catalin Miron, Theodor Asavei, Liviu Neagu, Markus Schöffler, Gregor Kastirke, Xiao-Jing Liu, Artem Rudenko, Shigeki Owada, Tetsuo Katayama, Tadashi Togashi, Kensuke Tono, Makina Yabashi, Hirohiko Kono, Kiyoshi Ueda
Coulomb explosion of diiodomethane CH2I2 molecules irradiated by ultrashort and intense X-ray pulses from SACLA, the Japanese X-ray free electron laser facility, was investigated by multi-ion coincidence measurements and self-consistent charge density-functional-based tight-binding (SCC-DFTB) simulations. The diiodomethane molecule, containing two heavy-atom X-ray absorbing sites, exhibits a rather different charge generation and nuclear motion dynamics compared to iodomethane CH3I with only a single heavy atom, as studied earlier...
May 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28530276/focus-a-metaheuristic-algorithm-for-computing-knockouts-from-genome-scale-models-for-strain-optimization
#11
Sarma Mutturi
Although handful tools are available for constraint-based flux analysis to generate knockout strains, most of these are either based on bilevel-MIP or its modifications. However, metaheuristic approaches that are known for their flexibility and scalability have been less studied. Moreover, in the existing tools, sectioning of search space to find optimal knocks has not been considered. Herein, a novel computational procedure, termed as FOCuS (Flower-pOllination coupled Clonal Selection algorithm), was developed to find the optimal reaction knockouts from a metabolic network to maximize the production of specific metabolites...
May 22, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28527796/genetic-parameters-of-mid-infrared-methane-predictions-and-their-relationships-with-milk-production-traits-in-holstein-cattle
#12
P B Kandel, M-L Vanrobays, A Vanlierde, F Dehareng, E Froidmont, N Gengler, H Soyeurt
Many countries have pledged to reduce greenhouse gases. In this context, the dairy sector is one of the identified sectors to adapt production circumstances to address socio-environmental constraints due to its large carbon footprint related to CH4 emission. This study aimed mainly to estimate (1) the genetic parameters of 2 milk mid-infrared-based CH4 proxies [predicted daily CH4 emission (PME, g/d), and log-transformed predicted CH4 intensity (LMI)] and (2) their genetic correlations with milk production traits [milk (MY), fat (FY), and protein (PY) yields] from first- and second-parity Holstein cows...
May 17, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28523740/new-data-about-semicircular-canal-morphology-and-locomotion-in-modern-hominoids
#13
Anne Le Maître, Philipp Schuetz, Patrick Vignaud, Michel Brunet
The labyrinth has two functional parts: the cochlea for audition and the vestibular system for equilibrioception. In the latter, the semicircular ducts and the otolithic organs are sensitive to rotational and linear accelerations of the head, respectively. The labyrinthine morphology influences perception accuracy, hence the adaptation to a specific locomotor pattern. The aim of this study is to determine the relationship between locomotion and semicircular canal morphology using geometric morphometrics, and to explain these links with existing functional models...
May 19, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28523274/identification-of-braf-positive-cases-based-on-whole-slide-image-analysis
#14
Vlad Popovici, Aleš Křenek, Eva Budinská
A key requirement for precision medicine is the accurate identification of patients that would respond to a specific treatment or those that represent a high-risk group, and a plethora of molecular biomarkers have been proposed for this purpose during the last decade. Their application in clinical settings, however, is not always straightforward due to relatively high costs of some tests, limited availability of the biological material and time, and procedural constraints. Hence, there is an increasing interest in constructing tissue-based surrogate biomarkers that could be applied with minimal overhead directly to histopathology images and which could be used for guiding the selection of eventual further molecular tests...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28518057/on-the-mechanistic-nature-of-epistasis-in-a-canonical-cis-regulatory-element
#15
Mato Lagator, Tiago Paixao, Nick Barton, Jonathan P Bollback, Călin C Guet
Understanding the relation between genotype and phenotype remains a major challenge. The difficulty of predicting individual mutation effects, and particularly the interactions between them, has prevented the development of a comprehensive theory that links genotypic changes to their phenotypic effects. We show that a general thermodynamic framework for gene regulation, based on a biophysical understanding of protein-DNA binding, accurately predicts the sign of epistasis in a canonical cis-regulatory element consisting of overlapping RNA polymerase and repressor binding sites...
May 18, 2017: ELife
https://www.readbyqxmd.com/read/28517949/cognitive-behavioral-treatments-for-criminogenic-thinking-barriers-and-facilitators-to-implementation-within-the-veterans-health-administration
#16
Daniel M Blonigen, Allison L Rodriguez, Luisa Manfredi, Andrea Nevedal, Joel Rosenthal, James F McGuire, David Smelson, Christine Timko
Cognitive-behavioral treatments for criminogenic thinking (i.e., antisocial cognitions, attitudes, and traits) are regarded as best practices for reducing criminal recidivism among justice-involved adults. However, the barriers and facilitators to implementation of these treatments within large health care systems such as the Veterans Health Administration (VHA) are largely unknown. To address this gap, we conducted qualitative interviews with 22 Specialists from the VHA's Veterans Justice Programs who had been trained in a cognitive-behavioral treatment for criminogenic thinking (i...
May 18, 2017: Psychological Services
https://www.readbyqxmd.com/read/28515890/sex-dependent-infection-causes-nonadditive-effects-on-kissing-bug-fecundity
#17
Carezza Botto-Mahan, Verónica Campos, Rodrigo Medel
The influence of parasites on host reproduction has been widely studied in natural and experimental conditions. Most studies, however, have evaluated the parasite impact on female hosts only, neglecting the contribution of males for host reproduction. This omission is unfortunate as sex-dependent infection may have important implications for host-parasite associations. Here, we evaluate for the first time the independent and nonindependent effects of gender infection on host reproductive success using the kissing bug Mepraia spinolai and the protozoan Trypanosoma cruzi as model system...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28515671/likelihood-analysis-of-the-minimal-amsb-model
#18
E Bagnaschi, M Borsato, K Sakurai, O Buchmueller, R Cavanaugh, V Chobanova, M Citron, J C Costa, A De Roeck, M J Dolan, J R Ellis, H Flächer, S Heinemeyer, G Isidori, M Lucio, F Luo, D Martínez Santos, K A Olive, A Richards, G Weiglein
We perform a likelihood analysis of the minimal anomaly-mediated supersymmetry-breaking (mAMSB) model using constraints from cosmology and accelerator experiments. We find that either a wino-like or a Higgsino-like neutralino LSP, [Formula: see text], may provide the cold dark matter (DM), both with similar likelihoods. The upper limit on the DM density from Planck and other experiments enforces [Formula: see text] after the inclusion of Sommerfeld enhancement in its annihilations. If most of the cold DM density is provided by the [Formula: see text], the measured value of the Higgs mass favours a limited range of [Formula: see text] (and also for [Formula: see text] if [Formula: see text]) but the scalar mass [Formula: see text] is poorly constrained...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28514629/the-emergent-properties-of-conspecific-attraction-can-limit-a-species-ability-to-track-environmental-change
#19
Kirk W Stodola, Michael P Ward
Multiple biotic, abiotic, and evolutionary constraints interact to determine a species' range. However, most species are not present in all suitable and accessible locations. Dispersal ability may explain why many species do not occupy all suitable habitat, but highly mobile species also exhibit a mismatch. Habitat selection behavior where individuals are site faithful and settle near conspecifics could create a social pressure that make a species' geographic range resistant to change. We investigated this possibility by using an individual-based model of habitat selection where habitat quality moved each year...
June 2017: American Naturalist
https://www.readbyqxmd.com/read/28512008/3d-printing-and-modelling-of-customized-implants-and-surgical-guides-for-non-human-primates
#20
Xing Chen, Jessy K Possel, Catherine Wacongne, Anne F van Ham, P Christiaan Klink, Pieter R Roelfsema
BACKGROUND: Primate neurobiologists use chronically implanted devices such as pedestals for head stabilization and chambers to gain access to the brain and study its activity. Such implants are skull-mounted, and made from a hard, durable material, such as titanium. NEW METHOD: Here we present a low-cost method of creating customized 3D-printed cranial implants that are tailored to the anatomy of individual animals. We performed pre-surgical computed tomography (CT) and magnetic resonance (MR) scans to generate three-dimensional (3D) models of the skull and brain...
May 13, 2017: Journal of Neuroscience Methods
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