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https://www.readbyqxmd.com/read/27892595/the-rate-of-change-in-alcohol-misuse-across-adolescence-is-heritable
#1
Alexis C Edwards, Jon Heron, Vladimir Vladimirov, Aaron R Wolen, Daniel E Adkins, Fazil Aliev, Matthew Hickman, Kenneth S Kendler
BACKGROUND: Alcohol use typically begins during adolescence and escalates into young adulthood. This represents an important period for the establishment of alcohol use and misuse patterns, which can have psychosocial and medical consequences. Although changes in alcohol use during this time have been phenotypically characterized, their genetic nature is poorly understood. METHODS: Participants of the Avon Longitudinal Study of Parents and Children completed the Alcohol Use Disorders Identification Test (AUDIT) 4 times from age 16 to 20...
November 28, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27879435/identification-of-mhc-haplotypes-associated-with-drug-induced-hypersensitivity-reactions-in-cynomolgus-monkeys
#2
Hong Wu, Jessica Whritenour, Jonathan C Sanford, Christopher Houle, Karissa K Adkins
Drug-induced hypersensitivity reactions can significantly impact drug development and use. Studies to understand risk factors for drug-induced hypersensitivity reactions have identified genetic association with specific human leukocyte antigen (HLA) alleles. Interestingly, drug-induced hypersensitivity reactions can occur in nonhuman primates; however, association between drug-induced hypersensitivity reactions and major histocompatibility complex (MHC) alleles has not been described. In this study, tissue samples were collected from 62 cynomolgus monkeys from preclinical studies in which 9 animals had evidence of drug-induced hypersensitivity reactions...
November 22, 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27854449/state-psychology-licensure-questions-about-mental-illness-and-compliance-with-the-americans-with-disabilities-act
#3
Jennifer E Boyd, Bruce Graunke, Frederick J Frese, James T R Jones, Jennifer W Adkins, Ronald Bassman
State licensing boards have obligations to protect the public from impaired professionals and to protect the rights of professionals applying for licensure. Competently functioning professionals who have or have had a mental health diagnosis or are being treated for a mental health condition should not be screened out, according to the Americans with Disabilities Act (ADA). A review of case law shows applicable precedents from discrimination among physicians and lawyers but not, to date, among psychologists...
2016: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/27834391/hippocampal-gabab-1a-receptors-constrain-generalized-contextual-fear
#4
Joseph F Lynch, Patrick Winiecki, T Lee Gilman, Jordan M Adkins, Aaron M Jasnow
Many anxiety disorders are characterized by generalization of fear responses to neutral or ambiguous stimuli. Therefore, a comprehensive understanding of the mechanisms contributing to generalized fear is essential for formulating successful treatments for anxiety disorders. Previous research shows that GABA-mediated presynaptic inhibition plays a critical role in cued fear generalization, as animals with genetically deleted presynaptic GABAB(1a) receptors cannot discriminate between CS+ and CS- tones. Work from our lab has further identified that GABAB(1a) receptors are necessary for maintaining contextual memory precision, thereby constraining generalized contextual fear...
November 11, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27830180/optimizing-porcine-islet-isolation-to-markedly-reduce-enzyme-consumption-without-sacrificing-islet-yield-or-function
#5
Robert W Holdcraft, Michael L Green, Andrew G Breite, Lisa Circle, Eric D Meyer, Hollie Adkins, Steven G Harbeck, Barry H Smith, Lawrence S Gazda
BACKGROUND: Human allogeneic islet transplantation for treatment of type 1 diabetes provides numerous clinical benefits, such as fewer episodes of hypoglycemic unawareness and tighter control of blood glucose levels. Availability of human pancreas for clinical and research use, however, is severely limited. Porcine pancreas offers an abundant source of tissue for optimization of islet isolation methodology and future clinical transplantation, thereby increasing patient access to this potentially lifesaving procedure...
July 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27822540/identification-of-novel-host-interactors-of-effectors-secreted-by-salmonella-and-citrobacter
#6
Ryan L Sontag, Ernesto S Nakayasu, Roslyn N Brown, George S Niemann, Michael A Sydor, Octavio Sanchez, Charles Ansong, Shao-Yeh Lu, Hyungwon Choi, Dylan Valleau, Karl K Weitz, Alexei Savchenko, Eric D Cambronne, Joshua N Adkins
Many pathogenic bacteria of the family Enterobacteriaceae use type III secretion systems to inject virulence proteins, termed "effectors," into the host cell cytosol. Although host-cellular activities of several effectors have been demonstrated, the function and host-targeted pathways of most of the effectors identified to date are largely undetermined. To gain insight into host proteins targeted by bacterial effectors, we performed coaffinity purification of host proteins from cell lysates using recombinant effectors from the Enterobacteriaceae intracellular pathogens Salmonella enterica serovar Typhimurium and Citrobacter rodentium...
July 2016: MSystems
https://www.readbyqxmd.com/read/27818141/hsp90-and-p23-molecular-chaperones-control-chromatin-architecture-by-maintaining-the-functional-pool-of-the-rsc-chromatin-remodeler
#7
Frank J Echtenkamp, Zlata Gvozdenov, Nicholas L Adkins, Yang Zhang, Melinda Lynch-Day, Shinya Watanabe, Craig L Peterson, Brian C Freeman
Molecular chaperones govern protein homeostasis, being allied to the beginning (folding) and ending (degradation) of the protein life cycle. Yet, the Hsp90 system primarily associates with native factors, including fully assembled complexes. The significance of these connections is poorly understood. To delineate why Hsp90 and its cochaperone p23 interact with a mature structure, we focused on the RSC chromatin remodeler. Both Hsp90 and p23 triggered the release of RSC from DNA or a nucleosome. Although Hsp90 only freed bound RSC, p23 enhanced nucleosome remodeling prior to discharging the complex...
December 1, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27815391/quantitative-fluorescent-microscopy-to-measure-vascular-pore-sizes-in-primary-and-metastatic-brain-tumors
#8
Rajendar K Mittapalli, Chris E Adkins, Kaci A Bohn, Afroz S Mohammad, Julie A Lockman, Paul R Lockman
Tumors residing in the central nervous system (CNS) compromise the blood-brain barrier (BBB) via increased vascular permeability, with the magnitude of changes dependent on tumor type and location. Current studies determine penetrability of a cancer therapeutic by administering progressively larger molecules until cutoff is observed where little to no tumor accumulation occurs. However, decades-old experimental work and mathematical modeling document methods to calculate both the size of the vascular opening (pore) with solute permeability values...
November 4, 2016: Cancer Research
https://www.readbyqxmd.com/read/27815095/neural-correlates-of-memory-encoding-and-recognition-for-own-race-and-other-race-faces-in-an-associative-memory-task
#9
Grit Herzmann, Greta Minor, Makenzie Adkins
The ability to recognize faces of family members, friends, and acquaintances plays an important role in our daily interactions. The other-race effect is the reduced ability to recognize other-race faces as compared to own-race faces. Previous studies showed different patterns of event-related potentials (ERPs) associated with recollection and familiarity during memory encoding (i.e., Dm) and recognition (i.e., parietal old/new effect) for own-race and other-race faces in a subjective-recollection task (remember-know judgments)...
November 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27803503/evaluation-of-pharmacist-impact-on-culture-review-process-for-patients-discharged-from-the-emergency-department
#10
Ruben D Santiago, Jose A Bazan, Nicole V Brown, Eric J Adkins, Mary Beth Shirk
Background: Accurate and timely review of microbiological test results is a core component of antimicrobial stewardship. There is documented success of these programs in the inpatient setting; however, emergency department (ED) patients are typically not included in these initiatives. Objectives: To assess the impact of an emergency medicine pharmacist (EMP)-facilitated review process of positive microbiological test results from patients discharged from the ED as measured by time to positive result review and number of indicated interventions completed...
October 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27793776/case-control-study-smoking-history-affects-the-production-of-tumor-antigen-specific-antibodies-ny-eso-1-in-patients-with-lung-cancer-in-comparison-with-cancer-disease-free-group
#11
Dagmar Myšíková, Irena Adkins, Hradilová Naďa, Palata Ondřej, Jan Šimonek, Jiří Pozniak, Jan Kolařík, Anna Skallová-Fialová, Radek Špíšek, Robert Lischke
INTRODUCTION: Lung cancer is the leading cause of cancer mortality worldwide therefore understanding the biological or clinical role of tumor associated antigens and autoantibodies is of an eminent interest for designing anti-tumor immunotherapeutic strategies. METHODS: Here we prospectively analyzed the serum frequencies of NY-ESO-1, Her2/neu and MAGE-A4 antibodies and corresponding antigens expression in tumors of 121 non-small cell lung (NSCLC) patients undergoing surgery without prior neoadjuvant chemotherapy and compared them with 57 control age-matched patients with no history of a malignant disease...
October 25, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27779626/snp-based-heritability-estimates-of-the-personality-dimensions-and-polygenic-prediction-of-both-neuroticism-and-major-depression-findings-from-converge
#12
A R Docherty, A Moscati, R Peterson, A C Edwards, D E Adkins, S A Bacanu, T B Bigdeli, B T Webb, J Flint, K S Kendler
Biometrical genetic studies suggest that the personality dimensions, including neuroticism, are moderately heritable (~0.4 to 0.6). Quantitative analyses that aggregate the effects of many common variants have recently further informed genetic research on European samples. However, there has been limited research to date on non-European populations. This study examined the personality dimensions in a large sample of Han Chinese descent (N=10 064) from the China, Oxford, and VCU Experimental Research on Genetic Epidemiology study, aimed at identifying genetic risk factors for recurrent major depression among a rigorously ascertained cohort...
October 25, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27777829/non-invasive-neuromodulation-using-time-varying-caloric-vestibular-stimulation
#13
Robert D Black, Lesco L Rogers, Kristen K Ade, Heather A Nicoletto, Heather D Adkins, Daniel T Laskowitz
Caloric vestibular stimulation (CVS) to elicit the vestibulo-ocular reflex has long been used in clinical settings to aid in the diagnosis of balance disorders and to confirm the absence of brainstem function. While a number of studies have hinted at the potential therapeutic applications of CVS, the limitations of existing devices have frustrated that potential. Current CVS irrigators use water or air during short-duration applications; however, this approach is not tenable for longer duration therapeutic protocols or home use...
2016: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/27749031/development-of-a-quasi-steady-flow-electrochemical-paper-based-analytical-device
#14
Jaclyn A Adkins, Eka Noviana, Charles S Henry
An electrochemical paper-based analytical device (ePAD) was developed for quasi-steady flow detection at microwire electrodes, for the first time. The device implements a fan shaped geometry connected to an analysis channel whereby solution is pulled from an inlet, through a channel, and into the steadily increasing capillary network of the fan. The network counteracts the decrease in solution flow rate associated with increasing viscosity within the channel, generating quasi-steady flow within the analysis channel...
October 17, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27747175/nuss-bar-procedure-past-present-and-future
#15
Donald Nuss, Robert J Obermeyer, Robert E Kelly
Repair of pectus excavatum began at the beginning of the 20(th) century before endotracheal intubation was standard practice. Surgeons therefore developed techniques that corrected the deformity using an open procedure via the anterior chest wall. Initial techniques were unsatisfactory, but by the 1930s the partial rib resection and sternal osteotomy technique had been developed and was used in combination with external traction post-operatively to prevent the sternum from sinking back into the chest. In 1949, Ravitch recommended complete resection of the costal cartilages and complete mobilization of the sternum without external traction, and in 1961 Adkins and Blades introduced the concept of a substernal strut for sternal support...
September 2016: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27746305/dusquetide-a-novel-innate-defense-regulator-demonstrating-a-significant-and-consistent-reduction-in-the-duration-of-oral-mucositis-in-preclinical-data-and-a-randomized-placebo-controlled-phase-2a-clinical-study
#16
Mahesh Kudrimoti, Amarintha Curtis, Samar Azawi, Francis Worden, Sanford Katz, Douglas Adkins, Marcelo Bonomi, Jenna Elder, Stephen T Sonis, Richard Straube, Oreola Donini
Dusquetide, a novel Innate Defense Regulator, modulates the innate immune system at a key convergence point in intracellular signaling pathways and has demonstrated activity in both reducing inflammation and increasing clearance of bacterial infection. Innate immunity has also been implicated in the pathogenesis of oral mucositis (OM), a universal toxicity of chemoradiation therapy (CRT). Testing the hypothesis that dusquetide can mitigate the development and duration of OM, preclinical studies have been completed and correlated with interim results from a Phase 2 clinical study in patients undergoing CRT for head and neck cancer...
October 13, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27735949/a-metabolic-synthetic-lethal-strategy-with-arginine-deprivation-and-chloroquine-leads-to-cell-death-in-ass1-deficient-sarcomas
#17
Gregory R Bean, Jeff C Kremer, Bethany C Prudner, Aaron D Schenone, Juo-Chin Yao, Matthew B Schultze, David Y Chen, Munir R Tanas, Douglas R Adkins, John Bomalaski, Brian P Rubin, Loren S Michel, Brian A Van Tine
Sarcomas comprise a large heterogeneous group of mesenchymal cancers with limited therapeutic options. When treated with standard cytotoxic chemotherapies, many sarcomas fail to respond completely and rapidly become treatment resistant. A major problem in the investigation and treatment of sarcomas is the fact that no single gene mutation or alteration has been identified among the diverse histologic subtypes. We searched for therapeutically druggable targets that are common to a wide range of histologies and hence could provide alternatives to the conventional chemotherapy...
October 13, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27708198/a-synopsis-of-the-influence-of-epigenetics-genetics-and-immunology-session-part-a-at-the-35th-annual-society-of-toxicologic-pathology-symposium
#18
Alison H Harrill, Jonathan G Moggs, Karissa K Adkins, Hellmut G Augustin, Robert C Johnson, Michael W Leach
The overarching theme of the 2016 Society of Toxicology Pathology's Annual Symposium was "The Basis and Relevance of Variation in Toxicologic Responses." Session 4 focused on genetic variation as a potential source for variability in toxicologic responses within nonclinical toxicity studies and further explored how knowledge of genetic traits might enable targeted prospective and retrospective studies in drug development and human health risk assessment. In this session, the influence of both genetic sequence variation and epigenetic modifications on toxicologic responses and their implications for understanding risk were explored...
October 5, 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27693381/disrupted-mitochondrial-genes-and-inflammation-following-stroke
#19
Whitney S Gibbs, Rachel A Weber, Rick G Schnellmann, DeAnna L Adkins
AIMS: Determine the subacute time course of mitochondria disruption, cell death, and inflammation in a rat model of unilateral motor cortical ischemic stroke. MAIN METHODS: Rats received unilateral ischemia of the motor cortex and were tested on behavioral tasks to determine impairments. Animals were euthanized at 24h, 72h and 144h and mRNA expression of key mitochondria proteins and indicators of inflammation, apoptosis and potential regenerative processes in ipsilesion cortex and striatum, using RT-qPCR...
September 27, 2016: Life Sciences
https://www.readbyqxmd.com/read/27688102/partner-an-open-label-randomized-phase-2-study-of-docetaxel-cisplatin-chemotherapy-with-or-without-panitumumab-as-first-line-treatment-for-recurrent-or-metastatic-squamous-cell-carcinoma-of-the-head-and-neck
#20
Lori J Wirth, Shaker Dakhil, Gabriela Kornek, Rita Axelrod, Douglas Adkins, Shubham Pant, Paul O'Brien, Philip R Debruyne, Kelly S Oliner, Jun Dong, Swami Murugappan
OBJECTIVE: This phase 2 estimation study evaluated docetaxel/cisplatin with/without panitumumab, an anti-epidermal growth factor receptor monoclonal antibody, as first-line therapy for recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN). PATIENTS AND METHODS: Randomized patients received docetaxel/cisplatin (75mg/m(2) each) with/without panitumumab (9mg/kg) in 21-day cycles. Patients randomized to panitumumab+chemotherapy could continue panitumumab monotherapy after completing six chemotherapy cycles without progression; patients randomized to chemotherapy alone could receive second-line panitumumab after progression...
October 2016: Oral Oncology
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