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https://www.readbyqxmd.com/read/28724738/early-life-manipulations-of-vasopressin-family-peptides-alter-vocal-learning
#1
Nicole M Baran, Samantha C Peck, Tabitha H Kim, Michael H Goldstein, Elizabeth Adkins-Regan
Vocal learning from social partners is crucial for the successful development of communication in a wide range of species. Social interactions organize attention and enhance motivation to learn species-typical behaviour. However, the neurobiological mechanisms connecting social motivation and vocal learning are unknown. Using zebra finches (Taeniopygia guttata), a ubiquitous model for vocal learning, we show that manipulations of nonapeptide hormones in the vasopressin family (arginine vasotocin, AVT) early in development can promote or disrupt both song and social motivation...
July 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28720698/catalysis-and-chemical-mechanisms-of-calcite-dissolution-in-seawater
#2
Adam V Subhas, Jess F Adkins, Nick E Rollins, John Naviaux, Jonathan Erez, William M Berelson
Near-equilibrium calcite dissolution in seawater contributes significantly to the regulation of atmospheric [Formula: see text] on 1,000-y timescales. Despite many studies on far-from-equilibrium dissolution, little is known about the detailed mechanisms responsible for calcite dissolution in seawater. In this paper, we dissolve (13)C-labeled calcites in natural seawater. We show that the time-evolving enrichment of [Formula: see text] in solution is a direct measure of both dissolution and precipitation reactions across a large range of saturation states...
July 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28706531/crop-production-under-drought-and-heat-stress-plant-responses-and-management-options
#3
REVIEW
Shah Fahad, Ali A Bajwa, Usman Nazir, Shakeel A Anjum, Ayesha Farooq, Ali Zohaib, Sehrish Sadia, Wajid Nasim, Steve Adkins, Shah Saud, Muhammad Z Ihsan, Hesham Alharby, Chao Wu, Depeng Wang, Jianliang Huang
Abiotic stresses are one of the major constraints to crop production and food security worldwide. The situation has aggravated due to the drastic and rapid changes in global climate. Heat and drought are undoubtedly the two most important stresses having huge impact on growth and productivity of the crops. It is very important to understand the physiological, biochemical, and ecological interventions related to these stresses for better management. A wide range of plant responses to these stresses could be generalized into morphological, physiological, and biochemical responses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28694292/specialized-pro-resolving-mediators-spm-rescue-infant-mice-from-lethal-citrobacter-rodentium-infection-and-promote-immunity-against-re-infection
#4
Luis Alonso Diaz, Norman H Altman, Wasif Khan, Charles N Serhan, Becky Adkins
Infants are generally highly susceptible to oral pathogens. Intestinal infection and the associated diarrhea are significant global causes of morbidity and mortality in infants. Among the enteric pathogens, enteropathogenic E. coli (EPEC) stands out as showing the highest risk for infection-induced death in infants ≤ 12 months old. We have developed an experimental model of infant infection with EPEC, using the murine specific pathogen Citrobacter rodentium Our murine infant model is similar to EPEC infection in human infants since infant mice are much more susceptible to C...
July 10, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28693348/calm-interventions-behavioral-health-crisis-assessment-linkage-and-management-improve-patient-care
#5
Natalie A Lester, Laura R Thompson, Kendal Herget, Julie A Stephens, John V Campo, Eric J Adkins, Thomas E Terndrup, Susan Moffatt-Bruce
Emergency departments (EDs) have seen rising numbers of patients in psychiatric crises, patient boarding, and throughput delays. This study describes and evaluates the impact of a Crisis Assessment Linkage and Management (CALM) service designed to manage behavioral health crises. A year-to-year comparison was performed before (n = 2211 ED visits) and after implementation of CALM (n = 2387). CALM was associated with reductions in median ED and hospital length of stay (LOS) from 9.5 to 7.3 hours and 46.2 to 31...
March 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28691140/preclinical-and-clinical-evidence-on-ipsilateral-corticospinal-projections-implication-for-motor-recovery
#6
REVIEW
Ali Alawieh, Stephen Tomlinson, DeAnna Adkins, Steve Kautz, Wuwei Feng
Motor impairment is the most common complication after stroke, and recovery of motor function has been shown to be dependent on the extent of lesion in the ipsilesional corticospinal tract (iCST) and activity within ipsilesional primary and secondary motor cortices. However, work from neuroimaging research has suggested a role of the contralesional hemisphere in promoting recovery after stroke potentially through the ipsilateral uncrossed CST fibers descending to ipsilateral spinal segments. These ipsilateral fibers, sometimes referred to as "latent" projections, are thought to contribute to motor recovery independent of the crossed CST...
July 9, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28669461/simulators-for-laryngeal-and-airway-surgery
#7
REVIEW
James A Burns, Lacey K Adkins, Seth Dailey, Adam M Klein
There is growing support from the Accreditation Council for Graduate Medical Education and the Joint Commission of Accreditation of Health Care Organizations for a competency-based evaluation of medical and surgical performance. This is part of the quality movement in health care whereby the Centers for Medicare and Medicaid Services and third-party insurance companies have begun to link reimbursement incentives to positive surgical outcomes. Laryngeal and airway surgery require precise technique and significant mastered skill that can be difficult to obtain during otolaryngology residency training...
June 29, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28660263/a-paper-based-colorimetric-spot-test-for-the-identification-of-adulterated-whiskeys
#8
Thiago M G Cardoso, Robert B Channon, Jaclyn A Adkins, Márcio Talhavini, Wendell K T Coltro, Charles S Henry
A colorimetric point-of-care paper-based analytical device (PAD) is developed for detecting adulterated beverages using whiskey falsified with caramel color as a model. Combining principal component analysis and calibration curves facilitated identification of adulteration in samples seized by the Brazilian Federal Police, at only ∼$0.02 per sample.
June 29, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28652787/oncology-drugs-for-orphan-indications-how-are-hta-processes-evolving-for-this-specific-drug-category
#9
REVIEW
Elizabeth M Adkins, Lindsay Nicholson, David Floyd, Mark Ratcliffe, Helene Chevrou-Severac
Orphan drugs (ODs) are intended for the diagnosis, prevention, or treatment of rare diseases. Many cancer subtypes, including all childhood cancers, are defined as rare diseases, and over one-third of ODs are now intended to treat oncology indications. However, market access for oncology ODs is becoming increasingly challenging; ODs are prone to significant uncertainty around their cost-effectiveness, while payers must balance the need for these vital innovations with growing sensitivity to rising costs. The objective of this review was to evaluate different mechanisms that have been introduced to facilitate patient access to oncology ODs in five different countries (Australia, Canada, England, France, and Sweden), using eight oncology ODs and non-orphan oncology drugs as examples of their application...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28649557/dusquetide-reduction-in-oral-mucositis-associated-with-enduring-ancillary-benefits-in-tumor-resolution-and-decreased-mortality-in-head-and-neck-cancer-patients
#10
Mahesh Kudrimoti, Amarinthia Curtis, Samar Azawi, Francis Worden, Sanford Katz, Douglas Adkins, Marcelo Bonomi, Zack Scott, Jenna Elder, Stephen T Sonis, Richard Straube, Oreola Donini
Innate immunity is a key component in the pathogenesis of oral mucositis, a universal toxicity of chemoradiation therapy (CRT). Dusquetide, a novel Innate Defense Regulator, has demonstrated both nonclinical and clinical efficacy in ameliorating severe oral mucositis (SOM). Long term follow-up studies from the Phase 2 clinical study evaluating dusquetide as a treatment for SOM in head and neck cancer (HNC) patients receiving CRT have now been completed. Extended analysis indicates that dusquetide therapy was well-tolerated and did not contribute to increased infection, tumor growth or mortality...
September 2017: Biotechnology Reports
https://www.readbyqxmd.com/read/28638734/severe-but-not-mild-heat-shock-treatment-induces-immunogenic-cell-death-in-cancer-cells
#11
Irena Adkins, Lenka Sadilkova, Nada Hradilova, Jakub Tomala, Marek Kovar, Radek Spisek
The mechanisms of immunogenicity underlying mild heat-shock (mHS) treatment < 42°C of tumor cells are largely attributed to the action of heat-shock proteins; however, little is known about the immunogenicity of tumor cells undergoing severe cytotoxic heat-shock treatment (sHS > 43°C). Here, we found that sHS, but not mHS (42°C), induces immunogenic cell death in human cancer cell lines as defined by the induction of ER stress response and ROS generation, cell surface exposure of calreticulin, HSP70 and HSP90, decrease of cell surface CD47, release of ATP and HMGB1...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28632246/declines-noted-in-cognitive-processes-and-association-with-achievement-among-children-with-leukemia
#12
Kathleen C Insel, Marilyn J Hockenberry, Lynette L Harris, Kari M Koerner, Zhenqiang Lu, Kristin B Adkins, Olga A Taylor, Patricia M Gundy, Ida M Moore
PURPOSE/OBJECTIVES: To assess change in specific cognitive processes during treatment with chemotherapy only among children with acute lymphoblastic leukemia (ALL). 
. DESIGN: A prospective, repeated measures design.
. SETTING: Pediatric oncology treatment centers at Banner-University Medical Center Tucson/Banner Children's-Diamond Medical Center (University of Arizona) and Texas Children's Cancer and Hematology centers (Baylor College of Medicine) in Houston...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28625169/is-there-a-decline-in-bovine-spongiform-encephalopathy-cases-born-after-reinforced-feed-bans-a-modelling-study-in-eu-member-states
#13
M E Arnold, R R L Simons, J Hope, N Gibbens, A L Adkin
Occasional cases of classical bovine spongiform encephalopathy (BSE) still continue to occur within the European Union (EU) for animals born after reinforced feed bans (BARBs), which should in theory have eliminated all risk of infection. The study aimed to determine (i) whether a common rate of decline of BSE infection was evident across EU member states, i.e. to determine whether control measures have been equally effective in all member states, (ii) whether there was any evidence of spontaneous occurrence of BSE in the data and (iii) the expected date for the last BSE case in UK...
June 19, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28609094/photochemical-bionanoreactor-for-efficient-visible-light-driven-in-vitro-drug-metabolism
#14
Xiaoni Fang, Yaokai Duan, Yujie Liu, Gary Adkins, Weijun Zang, Wenwan Zhong, Liang Qiao, Baohong Liu
In light of the significance of cytochrome P450 (CYP) catalyzed drug metabolism for drug development and toxicity screening, it is very important to imitate natural metabolic pathways accurately and efficiently in vitro. Herein, a novel and simple photochemical bionanoreactor has been constructed for efficient visible-light-driven in vitro drug metabolism based on eosin-Y-functionalized macroporous ordered silica foams (MOSF-EY). Because of the unique transfer of photoinduced electrons from photosensitizers to CYP heme domain, CYP catalyzed drug metabolism can be in vitro driven by the MOSF-EY nanoreactor under the irradiation of visible light...
June 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28599894/impact-of-aspirin-on-fetal-growth-in-diabetic-pregnancies-according-to-white-classification
#15
Katlynn Adkins, Amanda A Allshouse, Torri D Metz, Kent D Heyborne
BACKGROUND: Current US Preventive Services Task Force and other guidelines recommend low-dose aspirin for all pregnant women with pregestational diabetes mellitus to prevent preeclampsia and small-for-gestational-age birth. The Maternal-Fetal Medicine Units High-Risk Aspirin trial did not show a reduction in either preeclampsia or small-for-gestational-age birth in diabetic women. OBJECTIVE: Our objective was to reassess the impact of aspirin on fetal growth in diabetic pregnancies overall and according to White classification...
June 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28598664/measurement-of-d-0-azimuthal-anisotropy-at-midrapidity-in-au-au-collisions-at-sqrt-s_-nn-200%C3%A2-%C3%A2-gev
#16
L Adamczyk, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, N N Ajitanand, I Alekseev, D M Anderson, R Aoyama, A Aparin, D Arkhipkin, E C Aschenauer, M U Ashraf, A Attri, G S Averichev, X Bai, V Bairathi, A Behera, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, D Brown, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, N Chankova-Bunzarova, A Chatterjee, S Chattopadhyay, X Chen, J H Chen, X Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, R R Debbe, T G Dedovich, J Deng, A A Derevschikov, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, L E Dunkelberger, J C Dunlop, L G Efimov, N Elsey, J Engelage, G Eppley, R Esha, S Esumi, O Evdokimov, J Ewigleben, O Eyser, R Fatemi, S Fazio, P Federic, P Federicova, J Fedorisin, Z Feng, P Filip, E Finch, Y Fisyak, C E Flores, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, L Greiner, D Grosnick, D S Gunarathne, Y Guo, A Gupta, S Gupta, W Guryn, A I Hamad, A Hamed, A Harlenderova, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, G W Hoffmann, S Horvat, T Huang, B Huang, X Huang, H Z Huang, T J Humanic, P Huo, G Igo, W W Jacobs, A Jentsch, J Jia, K Jiang, S Jowzaee, E G Judd, S Kabana, D Kalinkin, K Kang, K Kauder, H W Ke, D Keane, A Kechechyan, Z Khan, D P Kikoła, I Kisel, A Kisiel, L Kochenda, M Kocmanek, T Kollegger, L K Kosarzewski, A F Kraishan, P Kravtsov, K Krueger, N Kulathunga, L Kumar, J Kvapil, J H Kwasizur, R Lacey, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, X Li, C Li, W Li, Y Li, J Lidrych, T Lin, M A Lisa, H Liu, P Liu, Y Liu, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, S Luo, X Luo, G L Ma, L Ma, Y G Ma, R Ma, N Magdy, R Majka, D Mallick, S Margetis, C Markert, H S Matis, K Meehan, J C Mei, Z W Miller, N G Minaev, S Mioduszewski, D Mishra, S Mizuno, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, Md Nasim, T K Nayak, J M Nelson, M Nie, G Nigmatkulov, T Niida, L V Nogach, T Nonaka, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, A M Poskanzer, N K Pruthi, M Przybycien, J Putschke, H Qiu, A Quintero, S Ramachandran, R L Ray, R Reed, M J Rehbein, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, J D Roth, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, S Salur, J Sandweiss, M Saur, J Schambach, A M Schmah, W B Schmidke, N Schmitz, B R Schweid, J Seger, M Sergeeva, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, A Sharma, M K Sharma, W Q Shen, Z Shi, S S Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, N Smirnov, D Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Strikhanov, B Stringfellow, T Sugiura, M Sumbera, B Summa, Y Sun, X M Sun, X Sun, B Surrow, D N Svirida, M A Szelezniak, A H Tang, Z Tang, A Taranenko, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, B A Trzeciak, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, A N Vasiliev, F Videbæk, S Vokal, S A Voloshin, A Vossen, G Wang, Y Wang, F Wang, Y Wang, J C Webb, G Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, W Xie, G Xie, J Xu, N Xu, Q H Xu, Y F Xu, Z Xu, Y Yang, Q Yang, C Yang, S Yang, Z Ye, Z Ye, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, Z Zhang, X P Zhang, J B Zhang, S Zhang, J Zhang, Y Zhang, J Zhang, S Zhang, J Zhao, C Zhong, L Zhou, C Zhou, X Zhu, Z Zhu, M Zyzak
We report the first measurement of the elliptic anisotropy (v_{2}) of the charm meson D^{0} at midrapidity (|y|<1) in Au+Au collisions at sqrt[s_{NN}]=200  GeV. The measurement was conducted by the STAR experiment at RHIC utilizing a new high-resolution silicon tracker. The measured D^{0} v_{2} in 0%-80% centrality Au+Au collisions can be described by a viscous hydrodynamic calculation for a transverse momentum (p_{T}) of less than 4  GeV/c. The D^{0} v_{2} as a function of transverse kinetic energy (m_{T}-m_{0}, where m_{T}=sqrt[p_{T}^{2}+m_{0}^{2}]) is consistent with that of light mesons in 10%-40% centrality Au+Au collisions...
May 26, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28596256/nccn-guidelines-insights-head-and-neck-cancers-version-2-2017
#17
David Adelstein, Maura L Gillison, David G Pfister, Sharon Spencer, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, A Dimitrios Colevas, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, William M Lydiatt, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Sue S Yom, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the head and neck (H&N), and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding the increase in human papillomavirus-associated oropharyngeal cancer and the availability of immunotherapy agents for treatment of patients with recurrent or metastatic H&N cancer...
June 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28595686/attitudes-of-nursing-facilities-staff-toward-pharmacy-students-interaction-with-its-residents
#18
Donna Adkins, Paul Gavaza, Sharon Deel
OBJECTIVE: All Appalachian College of Pharmacy second-year students undertake the longitudinal geriatric early pharmacy practice experiences (EPPE) 2 course, which involves interacting with geriatric residents in two nursing facilities over two semesters. The study investigated the nursing staff's perceptions about the rotation and the pharmacy students' interaction with nursing facility residents. STUDY DESIGN: Cross-sectional study. SETTING: Academic setting...
June 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28589244/does-spinal-excitability-scale-to-the-difficulty-of-the-dual-task
#19
Devon M Day, Mario T Boivin, Allan L Adkin, Craig D Tokuno
PURPOSE: This study examined whether spinal excitability, as measured by the soleus Hoffmann reflex (H-reflex), is scaled to the difficulty level of the dual-task being performed. METHODS: Twenty-two participants completed a combination of three balance task and three secondary cognitive (visuo-motor) task difficulty levels for a total of nine dual-task conditions. An additional eight participants were tested while performing the same three balance task difficulty levels on its own (i...
August 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28581523/a-dna-methylation-map-of-human-cancer-at-single-base-pair-resolution
#20
E Vidal, S Sayols, S Moran, A Guillaumet-Adkins, M P Schroeder, R Royo, M Orozco, M Gut, I Gut, N Lopez-Bigas, H Heyn, M Esteller
Although single base-pair resolution DNA methylation landscapes for embryonic and different somatic cell types provided important insights into epigenetic dynamics and cell-type specificity, such comprehensive profiling is incomplete across human cancer types. This prompted us to perform genome-wide DNA methylation profiling of 22 samples derived from normal tissues and associated neoplasms, including primary tumors and cancer cell lines. Unlike their invariant normal counterparts, cancer samples exhibited highly variable CpG methylation levels in a large proportion of the genome, involving progressive changes during tumor evolution...
June 5, 2017: Oncogene
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