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https://www.readbyqxmd.com/read/29149278/interdisciplinary-stem-education-reform-dishing-out-art-in-a-microbiology-laboratory
#1
Sarah J Adkins, Rachel K Rock, J Jeffrey Morris
In the modern educational framework, life science and visual art are usually presented as mutually exclusive subjects. Despite this perceived disciplinary contrast, visual art has the ability to engage and provoke students in ways that can have important downstream effects on scientific discovery, especially when applied in a practical setting such as a laboratory course. This review broadly examines the benefit of interdisciplinary fusions of science and art as well as recent ways in which art strategies have been used in undergraduate biology classrooms...
November 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29141203/mouse-adenovirus-type-1-infection-of-adipose-tissue
#2
Caitlyn T Molloy, Laura J Adkins, Cameron Griffin, Kanakadurga Singer, Jason B Weinberg
Human adenovirus (HAdV) type 36 seropositivity has been linked to obesity in humans. That link is supported by a small number of studies using HAdV-36 infection of animals that are not natural hosts for HAdVs. In this study, we infected mice with mouse adenovirus type 1 (MAV-1), a mouse pathogen, to determine whether MAV-1 infected adipose tissue and was associated with adipose tissue inflammation and obesity. We detected MAV-1 in adipose tissue during acute MAV-1 infection, but we did not detect virus-induced increases in adipose tissue cytokine expression or histological evidence of adipose tissue inflammation during acute infection...
November 12, 2017: Virus Research
https://www.readbyqxmd.com/read/29133896/the-food-borne-pathogen-campylobacter-jejuni-responds-to-the-bile-salt-deoxycholate-with-countermeasures-to-reactive-oxygen-species
#3
Nicholas M Negretti, Christopher R Gourley, Geremy Clair, Joshua N Adkins, Michael E Konkel
Bile plays an important role in digestion, absorption of fats, and the excretion of waste products, while concurrently providing a critical barrier against colonization by harmful bacteria. Previous studies have demonstrated that gut pathogens react to bile by adapting their protein synthesis. The ability of pathogens to respond to bile is remarkably complex and still incompletely understood. Here we show that Campylobacter jejuni, a leading bacterial cause of human diarrheal illness worldwide, responds to deoxycholate, a component of bile, by altering global gene transcription in a manner consistent with a strategy to mitigate exposure to reactive oxygen stress...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114401/aligner-optimization-increases-accuracy-and-decreases-compute-times-in-multi-species-sequence-data
#4
Kelly M Robinson, Aziah S Hawkins, Ivette Santana-Cruz, Ricky S Adkins, Amol C Shetty, Sushma Nagaraj, Lisa Sadzewicz, Luke J Tallon, David A Rasko, Claire M Fraser, Anup Mahurkar, Joana C Silva, Julie C Dunning Hotopp
As sequencing technologies have evolved, the tools to analyze these sequences have made similar advances. However, for multi-species samples, we observed important and adverse differences in alignment specificity and computation time for bwa- mem (Burrows-Wheeler aligner-maximum exact matches) relative to bwa-aln. Therefore, we sought to optimize bwa-mem for alignment of data from multi-species samples in order to reduce alignment time and increase the specificity of alignments. In the multi-species cases examined, there was one majority member (i...
September 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29110077/exploring-the-relationship-between-threat-related-changes-in-anxiety-attention-focus-and-postural-control
#5
Kyle J Johnson, Martin Zaback, Craig D Tokuno, Mark G Carpenter, Allan L Adkin
Individuals report directing attention toward and away from multiple sources when standing under height-related postural threat, and these changes in attention focus are associated with postural control modifications. As it is unknown whether these changes generalize to other types of threat situations, this study aimed to quantify changes in attention focus and examine their relationship with postural control changes in response to a direct threat to stability. Eighty young adults stood on a force plate fixed to a translating platform...
November 6, 2017: Psychological Research
https://www.readbyqxmd.com/read/29091730/probing-the-interaction-of-aspergillomarasmine-a-with-metallo-%C3%AE-lactamases-ndm-1-vim-2-and-imp-7
#6
Alexander Bergstrom, Andrew Katko, Zach Adkins, Jessica Hill, Zishuo Cheng, Mia Burnett, Hao Yang, Mahesh Aitha, M Rachel Mehaffey, Jennifer S Brodbelt, Kamaleddin H M E Tehrani, Nathaniel I Martin, Robert A Bonomo, Richard C Page, David L Tierney, Walter Fast, Gerard D Wright, Michael W Crowder
Metallo-β-lactamases (MBLs) are a growing threat to the continued efficacy of β-lactam antibiotics. Recently, aspergillomarasmine A (AMA) was identified as an MBL inhibitor, but the mode of inhibition was not fully characterized. Equilibrium dialysis and metal analysis studies revealed that 2 equiv of AMA effectively removes 1 equiv of Zn(II) from MBLs NDM-1, VIM-2, and IMP-7 when the MBL is at micromolar concentrations. Conversely, (1)H NMR studies revealed that 2 equiv of AMA remove 2 equiv of Co(II) from Co(II)-substituted NDM-1, VIM-2, and IMP-7 when the MBL/AMA are at millimolar concentrations...
November 9, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29091185/genomic-sequences-of-streptococcus-agalactiae-with-high-level-gentamicin-resistance-collected-in-the-bsac-bacteraemia-surveillance
#7
Michel Doumith, Shazad Mushtaq, Veronique Martin, Aiysha Chaudhry, Rachael Adkin, Juliana Coelho, Vicki Chalker, Alasdair MacGowan, Neil Woodford, David M Livermore
Background: Like other streptococci, Streptococcus agalactiae typically has intrinsic low-level aminoglycoside resistance. High-level gentamicin resistance was seen in 2 of 1125 isolates collected in the BSAC Bacteraemia Surveillance Programme between 2001 and 2014. These organisms, both isolated in 2014, were characterized. Methods: Identifications were by latex agglutination, MICs by BSAC agar dilution and sequencing by Illumina methodology. Results: Gentamicin MICs were >1024 mg/L versus a species mode of 8 mg/L; both isolates also were unusually ciprofloxacin resistant with MICs of 64 mg/L versus a species mode of 1 mg/L...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29088996/aggressive-treatment-of-life-threatening-hypophosphatemia-during-recovery-from-fulminant-hepatic-failure-a-case-report
#8
Brittany D Bissell, Jason E Davis, Alexander H Flannery, David A Adkins, Melissa L Thompson Bastin
Acute liver failure secondary to acetaminophen overdose can be a life-threatening condition, characterized by severe electrolyte derangements. Hepatocyte regeneration is associated with phosphorous utilization and is a known complication of liver recovery following injury. We report the case of profound, life-threatening hypophosphatemia following recovery from acute fulminant liver failure. As the liver enzymes normalized, serum phosphorous levels plummeted. Our patient required an aggressive, individualized phosphorus replacement regimen, which resulted in a continuous infusion of intravenous (IV) sodium phosphate, titrated to a maximum rate of 30 mmol/h or 0...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29069893/enhancement-of-the-intrinsic-peroxidase-like-activity-of-graphitic-carbon-nitride-nanosheets-by-ssdnas-and-its-application-for-detection-of-exosomes
#9
Yu-Min Wang, Jin-Wen Liu, Gary Brent Adkins, Wen Shen, Michael Patrick Trinh, Lu-Ying Duan, Jian-Hui Jiang, Wenwan Zhong
The present work investigates the capability of single-stranded DNA (ssDNA) in enhancing the intrinsic peroxidase-like activity of the g-C3N4 nanosheets (NSs). We found that ssDNA adsorbed on g-C3N4 NSs could improve the catalytic activity of the nanosheets. The maximum reaction rate of the H2O2-mediated TMB oxidation catalyzed by the ssDNA-NSs hybrid was at least 4 times faster than that obtained with unmodified NSs. The activity enhancement could be attributed to the strong interaction between TMB and ssDNA mediated by electrostatic attraction and aromatic stacking and by both the length and base composition of the ssDNA...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29063506/opportunities-for-an-enhanced-integration-of-neuroscience-and-genomics
#10
Ashlee A Moore, Chelsea Sawyers, Daniel E Adkins, Anna R Docherty
Neuroimaging and genetics are two rapidly expanding fields of research. Thoughtful integration of these areas is critical for ongoing large-scale research into the genetic mechanisms underlying brain structure, function, and development. Neuroimaging genetics has been slow to evolve relative to psychiatric genetics research, and some may be unaware that new statistical methods allow for the genomic analysis of more modestly-sized imaging samples. We present a broad overview of the extant imaging genetics literature, provide an interpretation of the major problems surrounding the integration of neuroimaging and genetics, discuss the influence and impact of genetics consortia, and suggest statistical genetic analyses that expand the repertoire of imaging researchers amassing rich behavioral data in modestly-sized samples...
October 23, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29039427/towards-a-taxonomy-of-topology-for-polynuclear-aromatic-hydrocarbons-linking-electronic-and-molecular-structure
#11
Erin M Adkins, J Houston Miller
Trends linking the topological characteristics of polynuclear aromatic hydrocarbons (PAH) to their electronic properties are reported. TD-DFT electronic spectra computations, using the 6-31G* basis set and B3LYP exchange correlation functional, were calculated for a series of PAH, allowing for the HOMO-LUMO gaps to be reported. Clar structures provide an avenue to link the physical structure and the aromaticity of the molecule; which, when extended by bond length and harmonic oscillator model of aromaticity analysis, provide powerful tools to understand the link between electronic and physical structure...
October 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29034689/autonomy-and-withdrawal-of-treatment-in-a-patient-with-depression
#12
Steven J Baumrucker, Patricia York, Matthew Stolick, Gregg VandeKieft, Laura Hutchinson, Russell W Adkins, Saima Rashid, Daniel Winiger
No abstract text is available yet for this article.
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29034677/rapid-enrichment-and-sensitive-detection-of-multiple-metal-ions-enabled-by-macroporous-graphene-foam
#13
Xiaoni Fang, Yang Liu, Luis Jimenez, Yaokai Duan, Gary Brent Adkins, Liang Qiao, Baohong Liu, Wenwan Zhong
Nanomaterials have shown great promise in advancing biomedical and environmental analysis because of the unique properties originated from their ultrafine dimensions. In general, nanomaterials are separately applied to either enhance detection by producing strong signals upon target recognition or to specifically extract analytes taking advantage of their high specific surface area. Herein, we report a dual-functional nanomaterial-based platform that can simultaneously enrich and enable sensitive detection of multiple metal ions...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28963620/impact-of-an-invasive-weed-parthenium-hysterophorus-on-a-pasture-community-in-south-east-queensland-australia
#14
Thi Nguyen, Ali Ahsan Bajwa, Amalia Belgeri, Sheldon Navie, Chris O'Donnell, Steve Adkins
Parthenium weed is a highly invasive alien species in more than 40 countries around the world. Along with severe negative effects on human and animal health and crop production, it also causes harm to ecosystem functioning by reducing the native plant species biodiversity. However, its impacts on native plant species, especially in pasture communities, are less known. Given parthenium weed causes substantial losses to Australian pastures' productivity, it is crucial to estimate its impact on pasture communities...
September 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28961841/dual-met-and-erbb-inhibition-overcomes-intratumor-plasticity-in-osimertinib-resistant-advanced-non-small-cell-lung-cancer-nsclc
#15
A Martinez-Marti, E Felip, J Matito, E Mereu, A Navarro, S Cedrés, N Pardo, A Martinez de Castro, J Remon, J M Miquel, A Guillaumet-Adkins, E Nadal, G Rodriguez-Esteban, O Arqués, R Fasani, P Nuciforo, H Heyn, A Villanueva, H G Palmer, A Vivancos
Background: Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as osimertinib are the last line of targeted treatment of metastatic non-small-cell lung cancer (NSCLC) EGFR-mutant harboring T790M. Different mechanisms of acquired resistance to third-generation EGFR-TKIs have been proposed. It is therefore crucial to identify new and effective strategies to overcome successive acquired mechanisms of resistance. Methods: For Amplicon-seq analysis, samples from the index patient (primary and metastasis lesions at different timepoints) as well as the patient-derived orthotopic xenograft tumors corresponding to the different treatment arms were used...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28958780/differential-impacts-of-participation-in-organized-activities-and-maltreatment-types-on-adolescent-academic-and-socioemotional-development
#16
Yoonyoung Kwak, Brittany Mihalec-Adkins, Aura A Mishra, Sharon L Christ
Participation in organized activities has been largely regarded as beneficial for academic and socioemotional development for adolescents, but the impacts of various types of organized activities for adolescents at risk for maltreatment have been rarely tested. In this study, we investigated the differential impacts of five types of maltreatment exposure (physical maltreatment, sexual maltreatment, neglect, other type, and multiple types) on the associations between four types of organized activities (mentored groups, art and music clubs, sport clubs, and academic clubs) and academic and socioemotional development (school engagement, delinquency, depressive symptoms, and trauma symptoms) of adolescents who were investigated by Child Protective Services (CPS) for maltreatment exposure...
September 25, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28949601/dijet-imbalance-measurements-in-au-au-and-pp-collisions-at-sqrt-s_-nn-200%C3%A2-%C3%A2-gev-at-star
#17
L Adamczyk, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, I Alekseev, D M Anderson, R Aoyama, A Aparin, D Arkhipkin, E C Aschenauer, M U Ashraf, A Attri, G S Averichev, X Bai, V Bairathi, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, D Brown, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, A Chatterjee, S Chattopadhyay, J H Chen, X Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, R R Debbe, T G Dedovich, J Deng, A A Derevschikov, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, C M Du, L E Dunkelberger, J C Dunlop, L G Efimov, N Elsey, J Engelage, G Eppley, R Esha, S Esumi, O Evdokimov, J Ewigleben, O Eyser, R Fatemi, S Fazio, P Federic, J Fedorisin, Z Feng, P Filip, E Finch, Y Fisyak, C E Flores, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, L Greiner, D Grosnick, D S Gunarathne, Y Guo, A Gupta, S Gupta, W Guryn, A I Hamad, A Hamed, R Haque, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, G W Hoffmann, S Horvat, X Huang, B Huang, H Z Huang, T Huang, P Huck, T J Humanic, G Igo, W W Jacobs, A Jentsch, J Jia, K Jiang, S Jowzaee, E G Judd, S Kabana, D Kalinkin, K Kang, K Kauder, H W Ke, D Keane, A Kechechyan, Z Khan, D P Kikoła, I Kisel, A Kisiel, L Kochenda, D D Koetke, L K Kosarzewski, A F Kraishan, P Kravtsov, K Krueger, L Kumar, M A C Lamont, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, W Li, X Li, X Li, Y Li, C Li, T Lin, M A Lisa, Y Liu, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, X Luo, S Luo, G L Ma, L Ma, R Ma, Y G Ma, N Magdy, R Majka, A Manion, S Margetis, C Markert, H S Matis, D McDonald, S McKinzie, K Meehan, J C Mei, Z W Miller, N G Minaev, S Mioduszewski, D Mishra, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, Md Nasim, T K Nayak, G Nigmatkulov, T Niida, L V Nogach, T Nonaka, J Novak, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y X Pan, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, A M Poskanzer, N K Pruthi, M Przybycien, J Putschke, H Qiu, A Quintero, S Ramachandran, R L Ray, R Reed, M J Rehbein, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, J D Roth, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, I Sakrejda, S Salur, J Sandweiss, J Schambach, R P Scharenberg, A M Schmah, W B Schmidke, N Schmitz, J Seger, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, M K Sharma, A Sharma, B Sharma, W Q Shen, S S Shi, Z Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, D Smirnov, N Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Stepanov, R Stock, M Strikhanov, B Stringfellow, T Sugiura, M Sumbera, B Summa, X M Sun, Z Sun, Y Sun, B Surrow, D N Svirida, Z Tang, A H Tang, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, A N Vasiliev, R Vertesi, F Videbæk, S Vokal, S A Voloshin, A Vossen, F Wang, J S Wang, G Wang, Y Wang, Y Wang, G Webb, J C Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, G Xie, W Xie, K Xin, Q H Xu, H Xu, Y F Xu, Z Xu, J Xu, N Xu, S Yang, Q Yang, Y Yang, C Yang, Y Yang, Y Yang, Z Ye, Z Ye, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, X P Zhang, J Zhang, J Zhang, Z Zhang, S Zhang, J B Zhang, Y Zhang, S Zhang, J Zhao, C Zhong, L Zhou, X Zhu, Y Zoulkarneeva, M Zyzak
We report the first dijet transverse momentum asymmetry measurements from Au+Au and pp collisions at RHIC. The two highest-energy back-to-back jets reconstructed from fragments with transverse momenta above 2  GeV/c display a significantly higher momentum imbalance in heavy-ion collisions than in the pp reference. When reexamined with correlated soft particles included, we observe that these dijets then exhibit a unique new feature-momentum balance is restored to that observed in pp for a jet resolution parameter of R=0...
August 11, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28939078/rationale-for-neoadjuvant-immunotherapy-in-head-and-neck-squamous-cell-carcinoma
#18
REVIEW
Glenn J Hanna, Douglas R Adkins, Paul Zolkind, Ravindra Uppaluri
The clinical benefit of immunotherapy in recurrent, metastatic head and neck squamous cell carcinoma has fueled interest in revisiting neoadjuvant approaches to complement definitive treatment. Neoadjuvant strategies incorporating immune checkpoint inhibitors and other novel immune-based therapies in head and neck cancer are reviewed here, with particular attention paid to the rationale for these approaches from both a clinical and biologic discovery standpoint. The potential benefits of neoadjuvant immunotherapy include reduction of extent of surgery and the intensity of adjuvant therapy by tumor downstaging, reduction of the risk of distant metastatic spread by early introduction of systemic therapy, conversion of unresectable to resectable disease, and early evaluation of biomarkers of tumor response...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28937942/evaluating-the-effect-of-a-campus-wide-social-norms-marketing-intervention-on-alcohol-use-perceptions-consumption-and-blackouts
#19
Jinni Su, Linda Hancock, Amanda Wattenmaker McGann, Mariam Alshagra, Rhianna Ericson, Zackaria Niazi, Danielle M Dick, Amy Adkins
Objective To evaluate the effect of a campus-wide social norms marketing intervention on alcohol-use perceptions, consumption, and blackouts at a large, urban, public university. Participants 4,172 college students (1,208 freshmen, 1,159 sophomores, 953 juniors, 852 seniors) who completed surveys in Spring 2015 for the Spit for Science Study, a longitudinal study of students' substance use and emotional health. Methods Participants were emailed an online survey that queried campaign readership, perception of peer alcohol use, alcohol consumption, frequency of consumption and frequency of blackouts...
September 22, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28934122/invasion-of-dendritic-cells-macrophages-and-neutrophils-by-the-bordetella-adenylate-cyclase-toxin-a-subversive-move-to-fool-host-immunity
#20
REVIEW
Giorgio Fedele, Ilaria Schiavoni, Irena Adkins, Nela Klimova, Peter Sebo
Adenylate cyclase toxin (CyaA) is released in the course of B. pertussis infection in the host's respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CD11b-expressing dendritic cells (DC), macrophages and neutrophils are professional phagocytes and key players of the innate immune system that provide a first line of defense against invading pathogens. Recent findings revealed the capacity of B. pertussis CyaA to intoxicate DC with high concentrations of 3',5'-cyclic adenosine monophosphate (cAMP), which ultimately skews the host immune response towards the expansion of Th17 cells and regulatory T cells...
September 21, 2017: Toxins
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