Cristina Howard-Varona, Morgan M Lindback, Jane D Fudyma, Azriel Krongauz, Natalie E Solonenko, Ahmed A Zayed, William B Andreopoulos, Heather M Olson, Young-Mo Kim, Jennifer E Kyle, Tijana Glavina Del Rio, Joshua N Adkins, Malak M Tfaily, Subhadeep Paul, Matthew B Sullivan, Melissa B Duhaime
Viruses impact microbial systems through killing hosts, horizontal gene transfer, and altering cellular metabolism, consequently impacting nutrient cycles. A virus-infected cell, a "virocell", is distinct from its uninfected sister cell as the virus commandeers cellular machinery to produce viruses rather than replicate cells. Problematically, virocell responses to the nutrient-limited conditions that abound in nature are poorly understood. Here we used a systems biology approach to investigate virocell metabolic reprogramming under nutrient limitation...
March 29, 2024: ISME Journal