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https://www.readbyqxmd.com/read/29346081/reported-balance-confidence-and-movement-reinvestment-of-younger-knee-replacement-patients-are-more-like-younger-healthy-individuals-than-older-patients
#1
Brian D Street, Allan Adkin, William Gage
This study focused on differences between the rapidly growing younger (<65 years old) and older (>65 years old) total knee replacement (TKR) patients for measures of balance confidence, movement reinvestment, and functional mobility. Fifty-nine participants, including twenty-nine primary unilateral TKR patients (six months post-TKR) formed the four experimental groups: 1) Younger TKR Patient (YP), 2) Younger Control (YC), 3) Older TKR Patient (OP), and 4) Older Control (OC). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Oxford Knee Score (OKS), Activities-specific Balance Confidence scale (ABC), the Movement-Specific Reinvestment Scale (MSRS), and the Timed Up and Go (TUG) test were measured...
January 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29311243/the-eif2%C3%AE-kinase-heme-regulated-inhibitor-hri-protects-the-host-from-infection-by-regulating-intracellular-pathogen-trafficking
#2
Wael Bahnan, Justin C Boucher, Petoria Gayle, Niraj Shrestha, Mark Rosen, Bertal Aktas, Becky Adkins, Arba Ager, Wasif N Khan, Kurt Schesser
The host employs both cell-autonomous and system-level responses to limit pathogen replication in the initial stages of infection. Previously, we reported that the eIF2α kinases Heme Regulator Inhibitor (HRI) and Protein Kinase R (PKR) control distinct cellular and immune-related activities in response to diverse bacterial pathogens. Specifically for Listeria monocytogenes, there was reduced translocation of the pathogen to the cytosolic compartment in HRI-deficient cells and consequently reduced loading of pathogen-derived antigens on MHC-1 complexes...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29307000/small-intestinal-bacterial-overgrowth-and-coronary-artery-disease-what-is-in-the-cards
#3
EDITORIAL
Christopher Adkins, Ali Rezaie
No abstract text is available yet for this article.
January 6, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29305574/anti-trop2-blockade-enhances-the-therapeutic-efficacy-of-erbb3-inhibition-in-head-and-neck-squamous-cell-carcinoma
#4
Nathan Redlich, Anthony M Robinson, Kwangok P Nickel, Andrew P Stein, Deric L Wheeler, Douglas R Adkins, Ravindra Uppaluri, Randall J Kimple, Brian A Van Tine, Loren S Michel
ErbB3 has been widely implicated in treatment resistance, but its role as a primary treatment target is less clear. Canonically ErbB3 requires EGFR or ErbB2 for activation, whereas these two established treatment targets are thought to signal independently of ErbB3. In this study, we show that ErbB3 is essential for tumor growth of treatment-naive HNSCC patient-derived xenografts. This ErbB3 dependency occurs via ErbB3-mediated control of EGFR activation and HIF1α stabilization, which require ErbB3 and its ligand neuregulin-1...
January 5, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29287798/lowering-prolactin-reduces-post-hatch-parental-care-in-male-and-female-zebra-finches-taeniopygia-guttata
#5
Kristina O Smiley, Elizabeth Adkins-Regan
Parental care is a widespread phenomenon observed in many diverse taxa. Neuroendocrine systems have long been thought to play an important role in stimulating the onset of parental behavior. In most birds with altricial young, circulating prolactin (PRL) levels are low during non-breeding times and significantly increase during late incubation and early post-hatch chick care. Because of this pattern, PRL has been suggested to be involved in the initiation of parental care in birds, but rarely has this hypothesis been causally tested...
December 26, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29261561/preterm-stress-behaviors-autonomic-indices-and-maternal-perceptions-of-infant-colic
#6
Fumiyuki C Gardner, Cherie S Adkins, Sarah E Hart, R Alberto Travagli, Kim Kopenhaver Doheny
BACKGROUND: While biological and behavioral stress response systems are intact in early gestation, preterm infants' behaviors are often more subtle and difficult to interpret compared with full-term infants. They are also more vulnerable for regulatory issues (ie, colic) that are known to impact caregiver-infant interactions. Biobehavioral measures such as behavioral responsivity and heart rate variability (HRV), particularly cardiac vagal tone, may help elucidate preterm infants' stress/regulatory systems...
December 19, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29247715/the-neonatal-window-of-opportunity-early-priming-for-life
#7
EDITORIAL
Harald Renz, Becky D Adkins, Sina Bartfeld, Richard S Blumberg, Donna L Farber, Johan Garssen, Peter Ghazal, David J Hackam, Benjamin J Marsland, Kathy D McCoy, John Penders, Immo Prinz, Valerie Verhasselt, Erika von Mutius, Jeffrey N Weiser, Duane R Wesemann, Mathias W Hornef
The concept of the neonatal window of opportunity assigns the early postnatal period a critical role for life-long host-microbial and immune homeostasis. It is supported by epidemiological evidence that links postnatal environmental exposure with disease susceptibility and mechanisms in the neonate host that facilitate the postnatal transposition, establish a stable microbiome and promote immune maturation. During the conference on "The neonatal window of opportunity - early priming for life", postnatal microbiome and immune maturation, epidemiological evidence and fundamental mechanisms were discussed to identify new targets for future preventive and interventional measures...
December 13, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29242347/comprehensive-computational-design-of-ordered-peptide-macrocycles
#8
Parisa Hosseinzadeh, Gaurav Bhardwaj, Vikram Khipple Mulligan, Matthew D Shortridge, Timothy W Craven, Fátima Pardo-Avila, Stephen A Rettie, David E Kim, Daniel-Adriano Silva, Yehia M Ibrahim, Ian K Webb, John R Cort, Joshua N Adkins, Gabriele Varani, David Baker
Mixed-chirality peptide macrocycles such as cyclosporine are among the most potent therapeutics identified to date, but there is currently no way to systematically search the structural space spanned by such compounds. Natural proteins do not provide a useful guide: Peptide macrocycles lack regular secondary structures and hydrophobic cores, and can contain local structures not accessible with l-amino acids. Here, we enumerate the stable structures that can be adopted by macrocyclic peptides composed of l- and d-amino acids by near-exhaustive backbone sampling followed by sequence design and energy landscape calculations...
December 15, 2017: Science
https://www.readbyqxmd.com/read/29241067/weed-seed-spread-and-its-prevention-the-role-of-roadside-wash-down
#9
Ali Ahsan Bajwa, Thi Nguyen, Sheldon Navie, Chris O'Donnell, Steve Adkins
Vehicles are one of the major vectors of long-distance weed seed spread. Viable seed removed from vehicles at roadside wash down facilities was studied at five locations in central Queensland, Australia over a 3-year period. Seed from 145 plant species, belonging to 34 different families, were identified in the sludge samples obtained from the wet particulate matter collection pit of the wash down facilities. Most of the species were annual forbs (50%) with small or very small seed size (<2 mm in diameter)...
December 11, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29240528/associations-between-sexual-risk-related-behaviors-and-school-based-education-on-hiv-and-condom-use-for-adolescent-sexual-minority-males-and-their-non-sexual-minority-peers
#10
Catherine N Rasberry, D Susanne Condron, Catherine A Lesesne, Susan Hocevar Adkins, Ganna Sheremenko, Elizabeth Kroupa
PURPOSE: With HIV and sexually transmitted disease (STD) rates disproportionately high among adolescent sexual minority males (ASMM), it is important to understand how school-based sexual health education may relate to sexual risk-related behavior among this population. This analysis explores reported HIV/AIDS- and condom-related education and sexual risk-related behaviors among ASMM and their adolescent non-sexual-minority male (non-ASMM) peers. METHODS: Students (n = 11,681) from seven Florida high schools completed paper-and-pencil questionnaires...
December 14, 2017: LGBT Health
https://www.readbyqxmd.com/read/29210918/association-between-physical-activity-and-adiposity-in-adolescents-with-down-syndrome
#11
E Andrew Pitchford, Chelsea Adkins, Rebecca E Hasson, Joseph E Hornyak, Dale A Ulrich
PURPOSE: Obesity is highly prevalent among adolescents with Down syndrome (DS); however, reported associations between body composition and moderate-to-vigorous physical activity (MVPA) have been small and non-significant. The purpose of this study to compare group differences between adolescents with and without DS, including dual-energy x-ray absorptiometry (DXA) measured body composition and accelerometer-measured physical activity, and then examine associations within adolescents with DS...
November 27, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29189333/symptom-management-and-palliative-care-in-pancreatic-cancer
#12
Michael W Rabow, Maria Q B Petzel, Sarah H Adkins
Evidence documents the benefits of palliative care to ameliorate the symptoms of pancreatic cancer as well as those from its treatment. Professional organizations now recommend palliative care for all patients with pancreatic cancer early in the course of illness and concurrently with active treatment. Scrupulous symptom management as well as sensitive communication and advance care planning allow oncologists to provide "primary palliative care" and to care well for patients with pancreatic cancer throughout the course of their illness...
November 2017: Cancer Journal
https://www.readbyqxmd.com/read/29181248/effect-of-heel-lifts-on-patellofemoral-joint-stress-during-running
#13
Zachary Mestelle, Thomas Kernozek, Kelly S Adkins, Jessica Miller, Naghmeh Gheidi
Background: Patellofemoral pain is a debilitating injury for many recreational runners. Excessive patellofemoral joint stress may be the underlying source of pain and interventions often focus on ways to reduce patellofemoral joint stress. Purpose: Heel lifts have been used as an intervention within Achilles tendon rehabilitation programs and to address leg length discrepancies. The purpose of this study was to examine the effect of running with heel lifts on patellofemoral joint stress, patellofemoral stress impulse, quadriceps force, step length, cadence, and other related kinematic and spatiotemporal variables...
October 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29174131/phase-1b-2a-trial-of-the-superoxide-dismutase-mimetic-gc4419-to-reduce-chemoradiotherapy-induced-oral-mucositis-in-patients-with-oral-cavity-or-oropharyngeal-carcinoma
#14
Carryn M Anderson, Stephen T Sonis, Christopher M Lee, Douglas Adkins, Bryan G Allen, Wenqing Sun, Sanjiv S Agarwala, Madhavi L Venigalla, Yuhchyau Chen, Weining Zhen, Diane R Mould, Jon T Holmlund, Jeffrey M Brill, John M Buatti
PURPOSE: To assess the safety of the superoxide dismutase mimetic GC4419 in combination with radiation and concurrent cisplatin for patients with oral cavity or oropharyngeal cancer (OCC) and to assess the potential of GC4419 to reduce severe oral mucositis (OM). PATIENTS AND METHODS: Patients with locally advanced OCC treated with definitive or postoperative intensity modulated radiation therapy (IMRT) plus cisplatin received GC4419 by 60-minute intravenous infusion, ending <60 minutes before IMRT, Monday through Friday for 3 to 7 weeks, in a dose and duration escalation study...
October 16, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29173193/polygenic-prediction-of-the-phenome-across-ancestry-in-emerging-adulthood
#15
Anna R Docherty, Arden Moscati, Danielle Dick, Jeanne E Savage, Jessica E Salvatore, Megan Cooke, Fazil Aliev, Ashlee A Moore, Alexis C Edwards, Brien P Riley, Daniel E Adkins, Roseann Peterson, Bradley T Webb, Silviu A Bacanu, Kenneth S Kendler
BACKGROUND: Identifying genetic relationships between complex traits in emerging adulthood can provide useful etiological insights into risk for psychopathology. College-age individuals are under-represented in genomic analyses thus far, and the majority of work has focused on the clinical disorder or cognitive abilities rather than normal-range behavioral outcomes. METHODS: This study examined a sample of emerging adults 18-22 years of age (N = 5947) to construct an atlas of polygenic risk for 33 traits predicting relevant phenotypic outcomes...
November 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29149278/interdisciplinary-stem-education-reform-dishing-out-art-in-a-microbiology-laboratory
#16
Sarah J Adkins, Rachel K Rock, J Jeffrey Morris
In the modern educational framework, life science and visual art are usually presented as mutually exclusive subjects. Despite this perceived disciplinary contrast, visual art has the ability to engage and provoke students in ways that can have important downstream effects on scientific discovery, especially when applied in a practical setting such as a laboratory course. This review broadly examines the benefit of interdisciplinary fusions of science and art as well as recent ways in which art strategies have been used in undergraduate biology classrooms...
November 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29141203/mouse-adenovirus-type-1-infection-of-adipose-tissue
#17
Caitlyn T Molloy, Laura J Adkins, Cameron Griffin, Kanakadurga Singer, Jason B Weinberg
Human adenovirus (HAdV) type 36 seropositivity has been linked to obesity in humans. That link is supported by a small number of studies using HAdV-36 infection of animals that are not natural hosts for HAdVs. In this study, we infected mice with mouse adenovirus type 1 (MAV-1), a mouse pathogen, to determine whether MAV-1 infected adipose tissue and was associated with adipose tissue inflammation and obesity. We detected MAV-1 in adipose tissue during acute MAV-1 infection, but we did not detect virus-induced increases in adipose tissue cytokine expression or histological evidence of adipose tissue inflammation during acute infection...
November 12, 2017: Virus Research
https://www.readbyqxmd.com/read/29133896/the-food-borne-pathogen-campylobacter-jejuni-responds-to-the-bile-salt-deoxycholate-with-countermeasures-to-reactive-oxygen-species
#18
Nicholas M Negretti, Christopher R Gourley, Geremy Clair, Joshua N Adkins, Michael E Konkel
Bile plays an important role in digestion, absorption of fats, and the excretion of waste products, while concurrently providing a critical barrier against colonization by harmful bacteria. Previous studies have demonstrated that gut pathogens react to bile by adapting their protein synthesis. The ability of pathogens to respond to bile is remarkably complex and still incompletely understood. Here we show that Campylobacter jejuni, a leading bacterial cause of human diarrheal illness worldwide, responds to deoxycholate, a component of bile, by altering global gene transcription in a manner consistent with a strategy to mitigate exposure to reactive oxygen stress...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114401/aligner-optimization-increases-accuracy-and-decreases-compute-times-in-multi-species-sequence-data
#19
Kelly M Robinson, Aziah S Hawkins, Ivette Santana-Cruz, Ricky S Adkins, Amol C Shetty, Sushma Nagaraj, Lisa Sadzewicz, Luke J Tallon, David A Rasko, Claire M Fraser, Anup Mahurkar, Joana C Silva, Julie C Dunning Hotopp
As sequencing technologies have evolved, the tools to analyze these sequences have made similar advances. However, for multi-species samples, we observed important and adverse differences in alignment specificity and computation time for bwa- mem (Burrows-Wheeler aligner-maximum exact matches) relative to bwa-aln. Therefore, we sought to optimize bwa-mem for alignment of data from multi-species samples in order to reduce alignment time and increase the specificity of alignments. In the multi-species cases examined, there was one majority member (i...
September 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29110077/exploring-the-relationship-between-threat-related-changes-in-anxiety-attention-focus-and-postural-control
#20
Kyle J Johnson, Martin Zaback, Craig D Tokuno, Mark G Carpenter, Allan L Adkin
Individuals report directing attention toward and away from multiple sources when standing under height-related postural threat, and these changes in attention focus are associated with postural control modifications. As it is unknown whether these changes generalize to other types of threat situations, this study aimed to quantify changes in attention focus and examine their relationship with postural control changes in response to a direct threat to stability. Eighty young adults stood on a force plate fixed to a translating platform...
November 6, 2017: Psychological Research
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