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https://www.readbyqxmd.com/read/28638734/severe-but-not-mild-heat-shock-treatment-induces-immunogenic-cell-death-in-cancer-cells
#1
Irena Adkins, Lenka Sadilkova, Nada Hradilova, Jakub Tomala, Marek Kovar, Radek Spisek
The mechanisms of immunogenicity underlying mild heat-shock (mHS) treatment < 42°C of tumor cells are largely attributed to the action of heat-shock proteins; however, little is known about the immunogenicity of tumor cells undergoing severe cytotoxic heat-shock treatment (sHS > 43°C). Here, we found that sHS, but not mHS (42°C), induces immunogenic cell death in human cancer cell lines as defined by the induction of ER stress response and ROS generation, cell surface exposure of calreticulin, HSP70 and HSP90, decrease of cell surface CD47, release of ATP and HMGB1...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28632246/declines-noted-in-cognitive-processes-and-association-with-achievement-among-children-with-leukemia
#2
Kathleen C Insel, Marilyn J Hockenberry, Lynette L Harris, Kari M Koerner, Zhenqiang Lu, Kristin B Adkins, Olga A Taylor, Patricia M Gundy, Ida M Moore
PURPOSE/OBJECTIVES: To assess change in specific cognitive processes during treatment with chemotherapy only among children with acute lymphoblastic leukemia (ALL). 
. DESIGN: A prospective, repeated measures design.
. SETTING: Pediatric oncology treatment centers at Banner-University Medical Center Tucson/Banner Children's-Diamond Medical Center (University of Arizona) and Texas Children's Cancer and Hematology centers (Baylor College of Medicine) in Houston...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28625169/is-there-a-decline-in-bovine-spongiform-encephalopathy-cases-born-after-reinforced-feed-bans-a-modelling-study-in-eu-member-states
#3
M E Arnold, R R L Simons, J Hope, N Gibbens, A L Adkin
Occasional cases of classical bovine spongiform encephalopathy (BSE) still continue to occur within the European Union (EU) for animals born after reinforced feed bans (BARBs), which should in theory have eliminated all risk of infection. The study aimed to determine (i) whether a common rate of decline of BSE infection was evident across EU member states, i.e. to determine whether control measures have been equally effective in all member states, (ii) whether there was any evidence of spontaneous occurrence of BSE in the data and (iii) the expected date for the last BSE case in UK...
June 19, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28609094/photochemical-bionanoreactor-for-efficient-visible-light-driven-in-vitro-drug-metabolism
#4
Xiaoni Fang, Yaokai Duan, Yujie Liu, Gary Adkins, Weijun Zang, Wenwan Zhong, Liang Qiao, Baohong Liu
In light of the significance of cytochrome P450 (CYP) catalyzed drug metabolism for
drug development and toxicity screening, it is very important to in-vitro imitate natural metabolic pathways accurately and efficiently. Herein, a novel and simple photochemical bionanoreactor has been constructed for efficient visible-light-driven in-vitro drug metabolism based on eosin Y functionalized macroporous ordered silica foams (MOSF-EY). Due to the unique transfer of photo-induced electrons from photo-sensitizers to CYP heme domain, CYP catalyzed drug metabolism can be in-vitro driven by the MOSF-EY nanoreactor under the irradiation of visible light...
June 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28599894/impact-of-aspirin-on-fetal-growth-in-diabetic-pregnancies-according-to-white-classification
#5
Katlynn Adkins, Amanda A Allshouse, Torri D Metz, Kent D Heyborne
OBJECTIVE: Current United States Preventative Services Task Force and other guidelines recommend low-dose aspirin for all pregnant women with pre-gestational diabetes mellitus to prevent preeclampsia and small for gestational age birth. The Maternal-Fetal Medicine Units High-Risk Aspirin trial did not show a reduction in either preeclampsia or small for gestational age birth in diabetic women. Our objective was to reassess the impact of aspirin on fetal growth in diabetic pregnancies overall and according to White classification...
June 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28598664/measurement-of-d-0-azimuthal-anisotropy-at-midrapidity-in-au-au-collisions-at-sqrt-s_-nn-200%C3%A2-%C3%A2-gev
#6
L Adamczyk, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, N N Ajitanand, I Alekseev, D M Anderson, R Aoyama, A Aparin, D Arkhipkin, E C Aschenauer, M U Ashraf, A Attri, G S Averichev, X Bai, V Bairathi, A Behera, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, D Brown, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, N Chankova-Bunzarova, A Chatterjee, S Chattopadhyay, X Chen, J H Chen, X Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, R R Debbe, T G Dedovich, J Deng, A A Derevschikov, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, L E Dunkelberger, J C Dunlop, L G Efimov, N Elsey, J Engelage, G Eppley, R Esha, S Esumi, O Evdokimov, J Ewigleben, O Eyser, R Fatemi, S Fazio, P Federic, P Federicova, J Fedorisin, Z Feng, P Filip, E Finch, Y Fisyak, C E Flores, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, L Greiner, D Grosnick, D S Gunarathne, Y Guo, A Gupta, S Gupta, W Guryn, A I Hamad, A Hamed, A Harlenderova, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, G W Hoffmann, S Horvat, T Huang, B Huang, X Huang, H Z Huang, T J Humanic, P Huo, G Igo, W W Jacobs, A Jentsch, J Jia, K Jiang, S Jowzaee, E G Judd, S Kabana, D Kalinkin, K Kang, K Kauder, H W Ke, D Keane, A Kechechyan, Z Khan, D P Kikoła, I Kisel, A Kisiel, L Kochenda, M Kocmanek, T Kollegger, L K Kosarzewski, A F Kraishan, P Kravtsov, K Krueger, N Kulathunga, L Kumar, J Kvapil, J H Kwasizur, R Lacey, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, X Li, C Li, W Li, Y Li, J Lidrych, T Lin, M A Lisa, H Liu, P Liu, Y Liu, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, S Luo, X Luo, G L Ma, L Ma, Y G Ma, R Ma, N Magdy, R Majka, D Mallick, S Margetis, C Markert, H S Matis, K Meehan, J C Mei, Z W Miller, N G Minaev, S Mioduszewski, D Mishra, S Mizuno, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, Md Nasim, T K Nayak, J M Nelson, M Nie, G Nigmatkulov, T Niida, L V Nogach, T Nonaka, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, A M Poskanzer, N K Pruthi, M Przybycien, J Putschke, H Qiu, A Quintero, S Ramachandran, R L Ray, R Reed, M J Rehbein, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, J D Roth, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, S Salur, J Sandweiss, M Saur, J Schambach, A M Schmah, W B Schmidke, N Schmitz, B R Schweid, J Seger, M Sergeeva, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, A Sharma, M K Sharma, W Q Shen, Z Shi, S S Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, N Smirnov, D Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Strikhanov, B Stringfellow, T Sugiura, M Sumbera, B Summa, Y Sun, X M Sun, X Sun, B Surrow, D N Svirida, M A Szelezniak, A H Tang, Z Tang, A Taranenko, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, B A Trzeciak, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, A N Vasiliev, F Videbæk, S Vokal, S A Voloshin, A Vossen, G Wang, Y Wang, F Wang, Y Wang, J C Webb, G Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, W Xie, G Xie, J Xu, N Xu, Q H Xu, Y F Xu, Z Xu, Y Yang, Q Yang, C Yang, S Yang, Z Ye, Z Ye, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, Z Zhang, X P Zhang, J B Zhang, S Zhang, J Zhang, Y Zhang, J Zhang, S Zhang, J Zhao, C Zhong, L Zhou, C Zhou, X Zhu, Z Zhu, M Zyzak
We report the first measurement of the elliptic anisotropy (v_{2}) of the charm meson D^{0} at midrapidity (|y|<1) in Au+Au collisions at sqrt[s_{NN}]=200  GeV. The measurement was conducted by the STAR experiment at RHIC utilizing a new high-resolution silicon tracker. The measured D^{0} v_{2} in 0%-80% centrality Au+Au collisions can be described by a viscous hydrodynamic calculation for a transverse momentum (p_{T}) of less than 4  GeV/c. The D^{0} v_{2} as a function of transverse kinetic energy (m_{T}-m_{0}, where m_{T}=sqrt[p_{T}^{2}+m_{0}^{2}]) is consistent with that of light mesons in 10%-40% centrality Au+Au collisions...
May 26, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28596256/nccn-guidelines-insights-head-and-neck-cancers-version-2-2017
#7
David Adelstein, Maura L Gillison, David G Pfister, Sharon Spencer, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, A Dimitrios Colevas, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, William M Lydiatt, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Sue S Yom, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the head and neck (H&N), and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding the increase in human papillomavirus-associated oropharyngeal cancer and the availability of immunotherapy agents for treatment of patients with recurrent or metastatic H&N cancer...
June 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28595686/attitudes-of-nursing-facilities-staff-toward-pharmacy-students-interaction-with-its-residents
#8
Donna Adkins, Paul Gavaza, Sharon Deel
OBJECTIVE: All Appalachian College of Pharmacy second-year students undertake the longitudinal geriatric early pharmacy practice experiences (EPPE) 2 course, which involves interacting with geriatric residents in two nursing facilities over two semesters. The study investigated the nursing staff's perceptions about the rotation and the pharmacy students' interaction with nursing facility residents. STUDY DESIGN: Cross-sectional study. SETTING: Academic setting...
June 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28589244/does-spinal-excitability-scale-to-the-difficulty-of-the-dual-task
#9
Devon M Day, Mario T Boivin, Allan L Adkin, Craig D Tokuno
PURPOSE: This study examined whether spinal excitability, as measured by the soleus Hoffmann reflex (H-reflex), is scaled to the difficulty level of the dual-task being performed. METHODS: Twenty-two participants completed a combination of three balance task and three secondary cognitive (visuo-motor) task difficulty levels for a total of nine dual-task conditions. An additional eight participants were tested while performing the same three balance task difficulty levels on its own (i...
June 6, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28581523/a-dna-methylation-map-of-human-cancer-at-single-base-pair-resolution
#10
E Vidal, S Sayols, S Moran, A Guillaumet-Adkins, M P Schroeder, R Royo, M Orozco, M Gut, I Gut, N Lopez-Bigas, H Heyn, M Esteller
Although single base-pair resolution DNA methylation landscapes for embryonic and different somatic cell types provided important insights into epigenetic dynamics and cell-type specificity, such comprehensive profiling is incomplete across human cancer types. This prompted us to perform genome-wide DNA methylation profiling of 22 samples derived from normal tissues and associated neoplasms, including primary tumors and cancer cell lines. Unlike their invariant normal counterparts, cancer samples exhibited highly variable CpG methylation levels in a large proportion of the genome, involving progressive changes during tumor evolution...
June 5, 2017: Oncogene
https://www.readbyqxmd.com/read/28580643/insights-into-pg-binding-conformational-change-and-dimerization-of-the-ompa-c-terminal-domains-from-salmonella-enterica-serovar-typhimurium-and-borrelia-burgdorferi
#11
Kemin Tan, Brooke L Deatherage Kaiser, Ruiying Wu, Marianne Cuff, Yao Fan, Lance Bigelow, Robert P Jedrzejczak, Joshua N Adkins, John R Cort, Gyorgy Babnigg, Andrzej Joachimiak
S. Typhimurium can induce both humoral and cell-mediated responses when establishing itself in the host. These responses are primarily stimulated against the lipopolysaccharide and major outer membrane (OM) proteins. OmpA is one of these major OM proteins. It comprises a N-terminal eight-stranded β-barrel trans membrane domain and a C-terminal domain (OmpA(CTD) ). The OmpA(CTD) and its homologs are believed to bind to peptidoglycan (PG) within the periplasm, maintaining bacterial osmotic homeostasis and modulating the permeability and integrity of the OM...
June 5, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28555774/post-fordist-reconfigurations-of-gender-work-and-life-theory-and-practice
#12
Breda Gray, Luigina Ciolfi, Aparecido Fabiano Pinatti de Carvalho, Anthony D'Andrea, Lisa Wixted
Based on an in-depth study with 56 informants (25 women and 31 men), across the ICT (information and communication technology), creative and academic sectors in one city/regional hub in Ireland, this article investigates the so-called revolution in work/life practices associated with the post-Fordist labour processes of the Knowledge Economy from the perspectives of workers themselves. Recent theorizations of post-Fordist work patterns emphasize a rearranging of work and life place boundaries; a reconfiguring of work and life time boundaries; and a dissolving of the gendered boundaries of work and life (production and social reproduction) (Adkins and Dever ; Morini and Fumagalli ; Gill and Pratt ; Weeks ; Hardt and Negri )...
May 29, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28540541/morphological-physiological-and-biochemical-responses-of-two-australian-biotypes-of-parthenium-hysterophorus-to-different-soil-moisture-regimes
#13
Ali Ahsan Bajwa, Bhagirath Singh Chauhan, Steve Adkins
Parthenium weed is a problematic invasive species in several countries around the world. Although it is considered to be a highly invasive species within Australia, not all biotypes of parthenium weed exhibit the same ability in regard to aggressive colonization and distribution. Differences among biotypes, particularly in regard to environmental ranges as a possible basis for this variation, have not always been elucidated. To determine whether drought tolerance could be a factor in biotype demographics, we quantified the biological responses of two Australian parthenium weed biotypes known to differ in invasive ability Clermont ("high") and Toogoolawah ("low") to 100, 75 and 50% of soil water holding capacity (WHC)...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28523557/single-cell-genomics-unravels-brain-cell-type-complexity
#14
Amy Guillaumet-Adkins, Holger Heyn
The brain is the most complex tissue in terms of cell types that it comprises, to the extent that it is still poorly understood. Single cell genome and transcriptome profiling allow to disentangle the neuronal heterogeneity, enabling the categorization of individual neurons into groups with similar molecular signatures. Herein, we unravel the current state of knowledge in single cell neurogenomics. We describe the molecular understanding of the cellular architecture of the mammalian nervous system in health and in disease; from the discovery of unrecognized cell types to the validation of known ones, applying these state-of-the-art technologies...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28520867/activity-of-ceftolozane-tazobactam-against-surveillance-and-problem-enterobacteriaceae-pseudomonas-aeruginosa-and-non-fermenters-from-the-british-isles
#15
David M Livermore, Shazad Mushtaq, Daniele Meunier, Katie L Hopkins, Robert Hill, Rachael Adkin, Aiysha Chaudhry, Rachel Pike, Peter Staves, Neil Woodford
Background: We assessed the activity of ceftolozane/tazobactam against consecutive isolates collected in the BSAC Bacteraemia Surveillance from 2011 to 2015 and against 'problem' isolates sent to the UK national reference laboratory from July 2015, when routine testing began. Methods: Susceptibility testing was by BSAC agar dilution with resistance mechanisms identified by PCR and interpretive reading. Results: Data were reviewed for 6080 BSAC surveillance isolates and 5473 referred organisms...
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28495513/high-hydrostatic-pressure-affects-antigenic-pool-in-tumor-cells-implication-for-dendritic-cell-based-cancer-immunotherapy
#16
Linda Urbanova, Nada Hradilova, Irena Moserova, Sarka Vosahlikova, Lenka Sadilkova, Michal Hensler, Radek Spisek, Irena Adkins
High hydrostatic pressure (HHP) can be used to generate dendritic cell (DC)-based active immunotherapy for prostate, lung and ovarian cancer. We showed here that HHP treatment of selected human cancer cell lines leads to a degradation of tumor antigens which depends on the magnitude of HHP applied and on the cancer cell line origin. Whereas prostate or ovarian cell lines displayed little protein antigen degradation with HHP treatment up to 300MPa after 2h, tumor antigens are hardly detected in lung cancer cell line after treatment with HHP 250MPa at the same time...
May 8, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28493153/a-bird-s-eye-view
#17
Elizabeth Adkins-Regan
No abstract text is available yet for this article.
May 10, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28481610/exploring-the-potential-of-technology-based-mental-health-services-for-homeless-youth-a-qualitative-study
#18
Elizabeth C Adkins, Alyson K Zalta, Randy A Boley, Angela Glover, Niranjan S Karnik, Stephen M Schueller
Homelessness has serious consequences for youth that heighten the need for mental health services; however, these individuals face significant barriers to access. New models of intervention delivery are required to improve the dissemination of mental health interventions that tailor these services to the unique challenges faced by homeless youth. The purpose of this study was to better understand homeless youths' use of technology, mental health experiences and needs, and willingness to engage with technology-supported mental health interventions to help guide the development of future youth-facing technology-supported interventions...
May 2017: Psychological Services
https://www.readbyqxmd.com/read/28474847/utilizing-paper-based-devices-for-antimicrobial-resistant-bacteria-detection
#19
Katherine E Boehle, Jake Gilliand, Christopher R Wheeldon, Amethyst Holder, Jaclyn A Adkins, Brian J Geiss, Elizabeth P Ryan, Charles S Henry
Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD 34 billion in the US and is predicted to be the number one cause of death worldwide by 2050. One way AMR bacteria can spread, and by which individuals can contract AMR infections, is through contaminated water. Monitoring AMR bacteria in the environment currently requires that samples be transported to a central laboratory for slow and labor intensive tests...
May 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28449639/clovr-comparative-automated-cloud-enabled-comparative-microbial-genome-sequence-analysis-pipeline
#20
Sonia Agrawal, Cesar Arze, Ricky S Adkins, Jonathan Crabtree, David Riley, Mahesh Vangala, Kevin Galens, Claire M Fraser, Hervé Tettelin, Owen White, Samuel V Angiuoli, Anup Mahurkar, W Florian Fricke
BACKGROUND: The benefit of increasing genomic sequence data to the scientific community depends on easy-to-use, scalable bioinformatics support. CloVR-Comparative combines commonly used bioinformatics tools into an intuitive, automated, and cloud-enabled analysis pipeline for comparative microbial genomics. RESULTS: CloVR-Comparative runs on annotated complete or draft genome sequences that are uploaded by the user or selected via a taxonomic tree-based user interface and downloaded from NCBI...
April 27, 2017: BMC Genomics
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