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https://www.readbyqxmd.com/read/28925994/chimeric-antigen-receptor-t-cell-therapy-assessment-and-management-of-toxicities
#1
REVIEW
Sattva S Neelapu, Sudhakar Tummala, Partow Kebriaei, William Wierda, Cristina Gutierrez, Frederick L Locke, Krishna V Komanduri, Yi Lin, Nitin Jain, Naval Daver, Jason Westin, Alison M Gulbis, Monica E Loghin, John F de Groot, Sherry Adkins, Suzanne E Davis, Katayoun Rezvani, Patrick Hwu, Elizabeth J Shpall
Immunotherapy using T cells genetically engineered to express a chimeric antigen receptor (CAR) is rapidly emerging as a promising new treatment for haematological and non-haematological malignancies. CAR-T-cell therapy can induce rapid and durable clinical responses, but is associated with unique acute toxicities, which can be severe or even fatal. Cytokine-release syndrome (CRS), the most commonly observed toxicity, can range in severity from low-grade constitutional symptoms to a high-grade syndrome associated with life-threatening multiorgan dysfunction; rarely, severe CRS can evolve into fulminant haemophagocytic lymphohistiocytosis (HLH)...
September 19, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28904165/the-importance-of-precision-assessments-when-serial-scanning
#2
Havilah Adkins
No abstract text is available yet for this article.
September 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28887541/evaluation-of-single-cell-genomics-to-address-evolutionary-questions-using-three-sags-of-the-choanoflagellate-monosiga-brevicollis
#3
David López-Escardó, Xavier Grau-Bové, Amy Guillaumet-Adkins, Marta Gut, Michael E Sieracki, Iñaki Ruiz-Trillo
Single-cell genomics (SCG) appeared as a powerful technique to get genomic information from uncultured organisms. However, SCG techniques suffer from biases at the whole genome amplification step that can lead to extremely variable numbers of genome recovery (5-100%). Thus, it is unclear how useful can SCG be to address evolutionary questions on uncultured microbial eukaryotes. To provide some insights into this, we here analysed 3 single-cell amplified genomes (SAGs) of the choanoflagellate Monosiga brevicollis, whose genome is known...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28885568/emotion-based-cognition-in-mice-is-differentially-influenced-by-dose-and-chemical-form-of-dietary-docosahexaenoic-acid
#4
Kevin D Laugero, Yuriko Adkins, Bruce E Mackey, Darshan S Kelley
Docosahexaenoic acid (DHA) is a major constituent, and primary omega-3 fatty acid, in the brain. Evidence suggests that DHA consumption may promote cognitive functioning and prevent cognitive decline, and these effects may be particularly relevant in the context of fear or stress. However, the potency and efficacy of dietary DHA may depend on the form of DHA (e.g., phospholipid; PL vs. triglyceride; TG). In this study, we compared in mice the effects of consuming PL and TG forms of DHA on associative, avoidance (fear) based learning and memory...
September 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28882331/demonstration-of-extended-field-of-view-ultrasound-s-potential-to-increase-the-pool-of-muscles-for-which-in-vivo-fascicle-length-is-measurable
#5
Amy N Adkins, Patrick W Franks, Wendy M Murray
Static, B-mode ultrasound is the most common method of measuring fascicle length in vivo. However, most forearm muscles have fascicles that are longer than the field-of-view of traditional ultrasound (T-US). As such, little work has been done to quantify in vivo forearm muscle architecture. The extended field-of-view ultrasound (EFOV-US) method, which fits together a sequence of B-mode images taken from a continuous ultrasound scan, facilitates direct measurements of longer, curved fascicles. Here, we test the validity and reliability of the EFOV-US method for obtaining fascicle lengths in the extensor carpi ulnaris (ECU)...
August 23, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28881377/comparison-of-unilateral-versus-bilateral-intensity-modulated-radiotherapy-for-surgically-treated-squamous-cell-carcinoma-of-the-palatine-tonsil
#6
Re-I Chin, Yuan James Rao, Michael Y Hwang, Christopher R Spencer, Michael Pierro, Todd DeWees, Pranav Patel, Parul Sinha, Hiram A Gay, Mackenzie Daly, Bruce H Haughey, Brian Nussenbaum, Douglas R Adkins, James S Lewis, Wade L Thorstad
BACKGROUND: The authors hypothesized that unilateral intensity-modulated radiotherapy (IMRT) would decrease toxicity compared with bilateral IMRT for patients with lateralized palatine tonsillar cancer and a neck classification of N0 to N2b, with similar oncological outcomes. METHODS: A total of 154 patients were treated with postoperative IMRT from 1997 through 2013. Data were collected prospectively from 2005 to 2013 and retrospectively collected before 2005. Of those patients with lateralized primary and N0 to N2b disease, 48 received unilateral IMRT (group 1) and 59 received bilateral IMRT (group 2); a total of 47 patients had nonlateralized primary or N2c to N3 disease and received bilateral IMRT (group 3)...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28876281/human-immunodeficiency-virus-chlamydia-and-gonorrhea-testing-in-new-york-medicaid-enrolled-adolescents
#7
Li Yan Wang, Man-Huei Chang, Gale Burstein, Susan Hocevar Adkins
BACKGROUND: Although growing public health efforts have been expended on increasing adolescents' access to human immunodeficiency virus (HIV) and sexually transmitted infection (STI) testing, little is known about the current utilization of those services in clinical settings. METHODS: Using 2010 to 2012 New York State Center for Medicare and Medicaid Services Medicaid Analytic eXtract data, we estimated the annual percentage of 13- to 19-year-olds who were tested for HIV, chlamydia (CT), and gonorrhea (GC)...
August 31, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28874529/synchronous-volcanic-eruptions-and-abrupt-climate-change-%C3%A2-17-7-ka-plausibly-linked-by-stratospheric-ozone-depletion
#8
Joseph R McConnell, Andrea Burke, Nelia W Dunbar, Peter Köhler, Jennie L Thomas, Monica M Arienzo, Nathan J Chellman, Olivia J Maselli, Michael Sigl, Jess F Adkins, Daniel Baggenstos, John F Burkhart, Edward J Brook, Christo Buizert, Jihong Cole-Dai, T J Fudge, Gregor Knorr, Hans-F Graf, Mackenzie M Grieman, Nels Iverson, Kenneth C McGwire, Robert Mulvaney, Guillaume Paris, Rachael H Rhodes, Eric S Saltzman, Jeffrey P Severinghaus, Jørgen Peder Steffensen, Kendrick C Taylor, Gisela Winckler
Glacial-state greenhouse gas concentrations and Southern Hemisphere climate conditions persisted until ∼17.7 ka, when a nearly synchronous acceleration in deglaciation was recorded in paleoclimate proxies in large parts of the Southern Hemisphere, with many changes ascribed to a sudden poleward shift in the Southern Hemisphere westerlies and subsequent climate impacts. We used high-resolution chemical measurements in the West Antarctic Ice Sheet Divide, Byrd, and other ice cores to document a unique, ∼192-y series of halogen-rich volcanic eruptions exactly at the start of accelerated deglaciation, with tephra identifying the nearby Mount Takahe volcano as the source...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28854650/host-mediated-effects-of-semipersistently-transmitted-squash-vein-yellowing-virus-on-sweetpotato-whitefly-hemiptera-aleyrodidae-behavior-and-fitness
#9
Deepak Shrestha, Heather J McAuslane, Scott T Adkins, Hugh A Smith, Nicholas Dufault, James Colee, Susan E Webb
Plant viruses may indirectly affect insect vector behavior and fitness via a shared host plant. Here, we evaluated the host-mediated effects of Squash vein yellowing virus (SqVYV) on the behavior and fitness of its whitefly vector, Bemisia tabaci (Gennadius) Middle East-Asia Minor 1, formerly biotype B. Alighting, settling, and oviposition behavioral assays were conducted on infected and mock-inoculated squash (Cucurbita pepo L.) and watermelon [Citrullus lanatus (Thunb) Matsum and Nakai] plants. Developmental time of immature stages, adult longevity, and fecundity were measured on infected and mock-inoculated squash plants...
August 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28854255/protein-abundances-can-distinguish-between-naturally-occurring-and-laboratory-strains-of-yersinia-pestis-the-causative-agent-of-plague
#10
Eric D Merkley, Landon H Sego, Andy Lin, Owen P Leiser, Brooke L Deatherage Kaiser, Joshua N Adkins, Paul S Keim, David M Wagner, Helen W Kreuzer
The rapid pace of bacterial evolution enables organisms to adapt to the laboratory environment with repeated passage and thus diverge from naturally-occurring environmental ("wild") strains. Distinguishing wild and laboratory strains is clearly important for biodefense and bioforensics; however, DNA sequence data alone has thus far not provided a clear signature, perhaps due to lack of understanding of how diverse genome changes lead to convergent phenotypes, difficulty in detecting certain types of mutations, or perhaps because some adaptive modifications are epigenetic...
2017: PloS One
https://www.readbyqxmd.com/read/28843493/utilization-of-ipsc-derived-human-neurons-for-high-throughput-drug-induced-peripheral-neuropathy-screening
#11
Payal Rana, Gregory Luerman, Dietmar Hess, Elizabeth Rubitski, Karissa Adkins, Christopher Somps
As the number of cancer survivors continues to grow, awareness of long-term toxicities and impact on quality of life after chemotherapy treatment in cancer survivors has intensified. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common side effects of modern chemotherapy. Animal models are used to study peripheral neuropathy and predict human risk; however, such models are labor-intensive and limited translatability between species has become a major challenge. Moreover, the mechanisms underlying CIPN have not been precisely determined and few human neuronal models to study CIPN exist...
August 24, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28822368/continuing-advancements-in-diagnosis-and-management-of-ampullary-adenoma
#12
Zachary Sanford, Jeremy Adkins, Chad Knight, Subrat Lahiry
No abstract text is available yet for this article.
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28808499/epigenetics-and-oxidative-stress-in-aging
#13
REVIEW
Amy Guillaumet-Adkins, Yania Yañez, Manuel D Peris-Diaz, Ines Calabria, Cora Palanca-Ballester, Juan Sandoval
Aging is a multifactorial process characterized by the progressive loss of physiological functions, leading to an increased vulnerability to age-associated diseases and finally to death. Several theories have been proposed to explain the nature of aging. One of the most known identifies the free radicals produced by the mitochondrial metabolism as the cause of cellular and DNA damage. However, there are also several evidences supporting that epigenetic modifications, such as DNA methylation, noncoding RNAs, and histone modifications, play a critical role in the molecular mechanism of aging...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28804159/geodesic-curvature-driven-surface-microdomain-formation
#14
Melissa R Adkins, Y C Zhou
Lipid bilayer membranes are not uniform and clusters of lipids in a more ordered state exist within the generally disorder lipid milieu of the membrane. These clusters of ordered lipids microdomains are now referred to as lipid rafts. Recent reports attribute the formation of these microdomains to the geometrical and molecular mechanical mismatch of lipids of different species on the boundary. Here we introduce the geodesic curvature to characterize the geometry of the domain boundary, and develop a geodesic curvature energy model to describe the formation of these microdomains as a result of energy minimization...
September 15, 2017: Journal of Computational Physics
https://www.readbyqxmd.com/read/28797466/trials-in-head-and-neck-oncology-evolution-of-perioperative-adjuvant-therapy
#15
REVIEW
Joseph Zenga, Patrik Pipkorn, Douglas R Adkins, Wade L Thorstad, Brian Nussenbaum
No abstract text is available yet for this article.
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797458/nab-paclitaxel-based-induction-chemotherapy-with-or-without-cetuximab-for-locally-advanced-head-and-neck-squamous-cell-carcinoma
#16
Douglas Adkins, Jessica Ley, Peter Oppelt, Tanya M Wildes, Hiram A Gay, Mackenzie Daly, Jason Rich, Randal C Paniello, Ryan Jackson, Patrik Pipkorn, Brian Nussenbaum, Kathryn Trinkaus, Wade Thorstad
OBJECTIVES: To explore the effect of incorporating cetuximab into induction chemotherapy in locally advanced head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Retrospective comparative analysis of two consecutive prospective phase II trials was performed: trial 1 with nab-paclitaxel/cisplatin/5-FU and cetuximab (APF-C; n=30) and trial 2 with APF (n=30). Patients were scheduled to receive chemoradiation therapy (CRT) with cisplatin. T2-4 classification oropharynx (OP)/larynx/hypopharynx SCC were included...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28760954/glacial-weathering-sulfide-oxidation-and-global-carbon-cycle-feedbacks
#17
Mark A Torres, Nils Moosdorf, Jens Hartmann, Jess F Adkins, A Joshua West
Connections between glaciation, chemical weathering, and the global carbon cycle could steer the evolution of global climate over geologic time, but even the directionality of feedbacks in this system remain to be resolved. Here, we assemble a compilation of hydrochemical data from glacierized catchments, use this data to evaluate the dominant chemical reactions associated with glacial weathering, and explore the implications for long-term geochemical cycles. Weathering yields from catchments in our compilation are higher than the global average, which results, in part, from higher runoff in glaciated catchments...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28758411/contemporary-demographic-treatment-and-geographic-distribution-patterns-for-disorders-of-sex-development
#18
Rohit Tejwani, Ruiyang Jiang, Steven Wolf, Deanna W Adkins, Brian J Young, Muhammad Alkazemi, John S Wiener, Gina-Maria Pomann, J Todd Purves, Jonathan C Routh
This study aimed to describe the demographic characteristics, hospital utilizations, patterns of inpatient surgical management, and the overall state/regional variation in surgery rate among patients with disorders of sex development (DSD). We analyzed the Nationwide Inpatient Sample from 2001 to 2012 for patients younger than 21 years. DSD-related diagnoses and procedures were identified via International Classification of Diseases, Ninth Revision (ICD-9) codes. We identified a total of 43,968 DSD-related admissions...
July 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28758136/a-mouse-model-of-focal-vascular-injury-induces-astrocyte-reactivity-tau-oligomers-and-aberrant-behavior
#19
Aric F Logsdon, Brandon P Lucke-Wold, Ryan C Turner, Xinlan Li, Chris E Adkins, Afroz S Mohammad, Jason D Huber, Charles L Rosen, Paul R Lockman
Neuropsychiatric symptom development has become more prevalent with 270,000 blast exposures occurring in the past 10 years in the United States. How blast injury leads to neuropsychiatric symptomology is currently unknown. Preclinical models of blast-induced traumatic brain injury have been used to demonstrate blood-brain barrier disruption, degenerative pathophysiology, and behavioral deficits. Vascular injury is a primary effect of neurotrauma that can trigger secondary injury cascades and neurodegeneration...
April 2017: Archives of Neuroscience
https://www.readbyqxmd.com/read/28750852/assessment-of-biosecurity-and-control-measures-to-prevent-incursion-and-to-limit-spread-of-emerging-transboundary-animal-diseases-in-europe-an-expert-survey
#20
Anaïs Léger, Marco De Nardi, Robin Simons, Amie Adkin, Giuseppe Ru, Agustín Estrada-Peña, Katharina D C Stärk
Decision-makers and risk managers are often called upon to prioritise on and recommend suitable measures to prevent the risk of introduction and spread of pathogens. The main objective of this study was to assess the perceptions of experts in Italy, Switzerland and the United Kingdom concerning the importance, effectiveness, feasibility, costs and acceptability of selected biosecurity measures to prevent the introduction and limit the spread of rabies, blue tongue (BT) and classical swine fever (CSF). After identifying the most relevant measures by the project team, an expert knowledge elicitation was implemented through a questionnaire...
July 24, 2017: Vaccine
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