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https://www.readbyqxmd.com/read/29788473/enhancing-psychosis-spectrum-nosology-through-an-international-data-sharing-initiative
#1
Anna R Docherty, Eduardo Fonseca-Pedrero, Martin Debbané, Raymond C K Chan, Richard J Linscott, Katherine G Jonas, David C Cicero, Melissa J Green, Leonard J Simms, Oliver Mason, David Watson, Ulrich Ettinger, Monika Waszczuk, Alexander Rapp, Phillip Grant, Roman Kotov, Colin G DeYoung, Camilo J Ruggero, Nicolas R Eaton, Robert F Krueger, Christopher Patrick, Christopher Hopwood, F Anthony O'Neill, David H Zald, Christopher C Conway, Daniel E Adkins, Irwin D Waldman, Jim van Os, Patrick F Sullivan, John S Anderson, Andrey A Shabalin, Scott R Sponheim, Stephan F Taylor, Rachel G Grazioplene, Silviu A Bacanu, Tim B Bigdeli, Corinna Haenschel, Dolores Malaspina, Diane C Gooding, Kristin Nicodemus, Frauke Schultze-Lutter, Neus Barrantes-Vidal, Christine Mohr, William T Carpenter, Alex S Cohen
The latent structure of schizotypy and psychosis-spectrum symptoms remains poorly understood. Furthermore, molecular genetic substrates are poorly defined, largely due to the substantial resources required to collect rich phenotypic data across diverse populations. Sample sizes of phenotypic studies are often insufficient for advanced structural equation modeling approaches. In the last 50 years, efforts in both psychiatry and psychological science have moved toward (1) a dimensional model of psychopathology (eg, the current Hierarchical Taxonomy of Psychopathology [HiTOP] initiative), (2) an integration of methods and measures across traits and units of analysis (eg, the RDoC initiative), and (3) powerful, impactful study designs maximizing sample size to detect subtle genomic variation relating to complex traits (the Psychiatric Genomics Consortium [PGC])...
May 16, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29785202/opto-thermoelectric-nanotweezers
#2
Linhan Lin, Mingsong Wang, Xiaolei Peng, Emanuel N Lissek, Zhangming Mao, Leonardo Scarabelli, Emily Adkins, Sahin Coskun, Husnu Emrah Unalan, Brian A Korgel, Luis M Liz-Marzán, Ernst-Ludwig Florin, Yuebing Zheng
Optical manipulation of plasmonic nanoparticles provides opportunities for fundamental and technical innovation in nanophotonics. Optical heating arising from the photon-to-phonon conversion is considered as an intrinsic loss in metal nanoparticles, which limits their applications. We show here that this drawback can be turned into an advantage, by developing an extremely low-power optical tweezing technique, termed opto-thermoelectric nanotweezers (OTENT). Through optically heating a thermoplasmonic substrate, alight-directed thermoelectric field can be generated due to spatial separation of dissolved ions within the heating laser spot, which allows us to manipulate metal nanoparticles of a wide range of materials, sizes and shapes with single-particle resolution...
April 2018: Nature Photonics
https://www.readbyqxmd.com/read/29752978/factors-that-influence-the-onset-of-parental-care-in-zebra-finches-roles-for-egg-stimuli-and-prolactin
#3
Kristina O Smiley, Elizabeth Adkins-Regan
Parental care is a critical component for determining reproductive success both for a current set of offspring but also over the lifetime of the individual. The hormone prolactin has often been implicated as a parental care hormone across taxa but causal relationships have only been strongly demonstrated in mammals and few select species of birds. For instance, in mammals, maternal care towards foster pups can be induced by exogenous treatment with prolactin, in concert with other reproductive hormones involved in pregnancy...
May 9, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29752322/nccn-guidelines-insights-head-and-neck-cancers-version-1-2018
#4
A Dimitrios Colevas, Sue S Yom, David G Pfister, Sharon Spencer, David Adelstein, Douglas Adkins, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, David W Eisele, Moon Fenton, Robert L Foote, Jill Gilbert, Maura L Gillison, Robert I Haddad, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Debra Leizman, Ellie Maghami, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, James Rocco, Cristina P Rodriguez, Jatin P Shah, Randal S Weber, Matthew Witek, Frank Worden, Weining Zhen, Jennifer L Burns, Susan D Darlow
The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult primary of the H&N, and separate algorithms have been developed by the panel for very advanced H&N cancers. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding evaluation and treatment of nasopharyngeal carcinoma...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29749048/evaluation-of-projection-and-dual-energy-based-methods-for-metal-artifact-reduction-in-ct-using-a-phantom-study
#5
Zaiyang Long, Michael R Bruesewitz, David R DeLone, Jonathan M Morris, Kimberly K Amrami, Mark C Adkins, Katrina N Glazebrook, James M Kofler, Shuai Leng, Cynthia H McCollough, Joel G Fletcher, Ahmed F Halaweish, Lifeng Yu
OBJECTIVES: Both projection and dual-energy (DE)-based methods have been used for metal artifact reduction (MAR) in CT. The two methods can also be combined. The purpose of this work was to evaluate these three MAR methods using phantom experiments for five types of metal implants. MATERIALS AND METHODS: Five phantoms representing spine, dental, hip, shoulder, and knee were constructed with metal implants. These phantoms were scanned using both single-energy (SE) and DE protocols with matched radiation output...
May 10, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29739336/circular-rna-expression-and-regulatory-network-prediction-in-posterior-cingulate-astrocytes-in-elderly-subjects
#6
Shobana Sekar, Lori Cuyugan, Jonathan Adkins, Philipp Geiger, Winnie S Liang
BACKGROUND: Circular RNAs (circRNAs) are a novel class of endogenous, non-coding RNAs that form covalently closed continuous loops and that are both highly conserved and abundant in the mammalian brain. A role for circRNAs in sponging microRNAs (miRNAs) has been proposed, but the circRNA-miRNA-mRNA interaction networks in human brain cells have not been defined. Therefore, we identified circRNAs in RNA sequencing data previously generated from astrocytes microdissected from the posterior cingulate (PC) of Alzheimer's disease (AD) patients (N = 10) and healthy elderly controls (N = 10) using four circRNA prediction algorithms - CIRI, CIRCexplorer, find_circ and KNIFE...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29727499/learning-to-balance-on-a-slackline-development-of-coordinated-multi-joint-synergies
#7
Robyn L Mildren, Martin Zaback, Allan L Adkin, Leah R Bent, James S Frank
Previous research has investigated synergies involved in locomotion and balance reactions; however, there is limited insight into the emergence of skilled balance control with practice of challenging tasks. We explored motor learning of tandem and single leg stance on an unstable surface - a slackline. Balance was tested in 10 naïve healthy adults at four time points: baseline, after one slackline practice session, after one week of practice, and one week following the final practice session. We recorded kinematics of the upper and lower arms bilaterally, trunk, and thigh and foot unilaterally while participants balanced in tandem and single leg stance on a slackline and narrow rigid beam (transfer task)...
May 4, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29724792/bigscale-an-analytical-framework-for-big-scale-single-cell-data
#8
Giovanni Iacono, Elisabetta Mereu, Amy Guillaumet-Adkins, Roser Corominas, Ivon Cuscó, Gustavo Rodríguez-Esteban, Marta Gut, Luis Alberto Pérez-Jurado, Ivo Gut, Holger Heyn
Single-cell RNA sequencing (scRNA-seq) has significantly deepened our insights into complex tissues, with the latest techniques capable of processing tens of thousands of cells simultaneously. Analyzing increasing numbers of cells, however, generates extremely large data sets, extending processing time and challenging computing resources. Current scRNA-seq analysis tools are not designed to interrogate large data sets and often lack sensitivity to identify marker genes. With bigSCale, we provide a scalable analytical framework to analyze millions of cells, which addresses the challenges associated with large data sets...
May 3, 2018: Genome Research
https://www.readbyqxmd.com/read/29715530/characterizing-the-corticomotor-connectivity-of-the-bilateral-ankle-muscles-during-rest-and-isometric-contraction-in-healthy-adults
#9
Charalambos C Charalambous, Jesse C Dean, DeAnna L Adkins, Colleen A Hanlon, Mark G Bowden
The investigation of the corticomotor connectivity (CMC) to leg muscles is an emerging research area, and establishing reliability of measures is critical. This study examined the measurement reliability and the differences between bilateral soleus (SOL) and tibialis anterior (TA) CMC in 21 neurologically intact adults. Using single pulse transcranial magnetic stimulation (TMS), each muscle's CMC was assessed twice (7 ± 2 days apart) during rest and active conditions. CMC was quantified using a standardized battery of eight measures (4/condition): motor threshold during resting (RMT), motor evoked potential amplitude and latency (raw and normalized to height) in both conditions, contralateral silent period (CSP) during active...
April 24, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29705416/use-of-maldi-tof-to-characterize-staphylococcal-intramammary-infections-in-dairy-goats
#10
Véronique Bernier Gosselin, Jessica Lovstad, Simon Dufour, Pamela R F Adkins, John R Middleton
The most common pathogens causing intramammary infections (IMI) in dairy goats are staphylococci. Gene sequencing has been the reference method for identification of staphylococcal species, but MALDI-TOF mass spectrometry could represent a rapid and cost-effective alternative method. The objectives were to evaluate the typeability and accuracy of partial gene sequencing and MALDI-TOF for identifying staphylococci isolated from caprine milk samples, and to evaluate the relationship between staphylococcal species IMI, milk somatic cell score (SCS), and milk yield (MY)...
April 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29704696/evaluation-of-cross-sectional-and-longitudinal-changes-in-volumetric-bone-mineral-density-in-postmenopausal-women-using-single-versus-dual-energy-quantitative-computed-tomography
#11
Jad G Sfeir, Matthew T Drake, Elizabeth J Atkinson, Sara J Achenbach, Jon J Camp, Amanda J Tweed, Louise K McCready, Lifeng Yu, Mark C Adkins, Shreyasee Amin, Sundeep Khosla
Central quantitative computed tomography (QCT) is increasingly used in clinical trials and practice to assess bone mass or strength and to evaluate longitudinal changes in response to drug treatment. Current studies utilize single-energy (SE) QCT scans, which may be confounded both by the amount of bone marrow fat at baseline and changes in marrow fat over time. However, the extent to which marrow fat changes either underestimate volumetric BMD (vBMD) measurements at baseline or under-/overestimate longitudinal changes in vivo in humans remains unclear...
April 25, 2018: Bone
https://www.readbyqxmd.com/read/29649039/barriers-to-rehabilitation-care-in-pediatric-cochlear-implant-recipients
#12
Bryce Noblitt, Kristan P Alfonso, Margaret Adkins, Matthew L Bush
OBJECTIVE: The purpose of this study was to assess barriers to rehabilitation care for pediatric cochlear implant (CI) recipients. STUDY DESIGN: Cross-sectional questionnaire study. SETTING: Tertiary medical center. PATIENTS: Parents of children who received a CI from October 1996 to June 2013. MAIN OUTCOME MEASURE(S): Factors related to access to and barriers in audiology and speech therapy services, factors related to CI use, and performance with CI using the Parents' Evaluation of Aural/Oral Performance of Children (PEACH)...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29621891/critically-ill-patient-leaving-against-medical-advice
#13
Steven J Baumrucker, Gregory T Carter, Matt Stolick, Patricia York, Laura Hutchinson, Daniel Winiger, Russel W Adkins
No abstract text is available yet for this article.
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29584545/antitumor-activity-of-nivolumab-in-recurrent-and-metastatic-nasopharyngeal-carcinoma-an-international-multicenter-study-of-the-mayo-clinic-phase-2-consortium-nci-9742
#14
Brigette B Y Ma, Wan-Teck Lim, Boon-Cher Goh, Edwin P Hui, Kwok-Wai Lo, Adam Pettinger, Nathan R Foster, Jonathan W Riess, Mark Agulnik, Alex Y C Chang, Akhil Chopra, Julie A Kish, Christine H Chung, Douglas R Adkins, Kevin J Cullen, Barbara J Gitlitz, Dean W Lim, Ka-Fai To, K C Allen Chan, Y M Dennis Lo, Ann D King, Charles Erlichman, Jun Yin, Brian A Costello, Anthony T C Chan
Purpose This multinational study evaluated the antitumor activity of nivolumab in nasopharyngeal carcinoma (NPC). Tumor and plasma-based biomarkers were investigated in an exploratory analysis. Patients and Methods Patients with multiply pretreated recurrent or metastatic NPC were treated with nivolumab until disease progression. The primary end point was objective response rate (ORR) and secondary end points included survival and toxicity. The expression of programmed death-ligand 1 (PD-L1) and human leukocyte antigens A and B in archived tumors and plasma clearance of Epstein-Barr virus DNA were correlated with ORR and survival...
May 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29568113/multiple-mechanisms-drive-phage-infection-efficiency-in-nearly-identical-hosts
#15
Cristina Howard-Varona, Katherine R Hargreaves, Natalie E Solonenko, Lye Meng Markillie, Richard Allen White, Heather M Brewer, Charles Ansong, Galya Orr, Joshua N Adkins, Matthew B Sullivan
Phage-host interactions are critical to ecology, evolution, and biotechnology. Central to those is infection efficiency, which remains poorly understood, particularly in nature. Here we apply genome-wide transcriptomics and proteomics to investigate infection efficiency in nature's own experiment: two nearly identical (genetically and physiologically) Bacteroidetes bacterial strains (host18 and host38) that are genetically intractable, but environmentally important, where phage infection efficiency varies. On host18, specialist phage phi18:3 infects efficiently, whereas generalist phi38:1 infects inefficiently...
June 2018: ISME Journal
https://www.readbyqxmd.com/read/29562604/a-review-of-the-health-benefits-of-cherries
#16
REVIEW
Darshan S Kelley, Yuriko Adkins, Kevin D Laugero
Increased oxidative stress contributes to development and progression of several human chronic inflammatory diseases. Cherries are a rich source of polyphenols and vitamin C which have anti-oxidant and anti-inflammatory properties. Our aim is to summarize results from human studies regarding health benefits of both sweet and tart cherries, including products made from them (juice, powder, concentrate, capsules); all referred to as cherries here. We found 29 (tart 20, sweet 7, unspecified 2) published human studies which examined health benefits of consuming cherries...
March 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29547838/the-benefits-of-early-care-and-education-for-child-welfare-involved-children-perspectives-from-the-field
#17
Sacha Klein, Brittany Mihalec-Adkins, Stephanie Benson, Sei-Young Lee
Increasing access to early care and education (ECE) for children in the child welfare system (CWS) remains a critical issue in the United States, as the numbers of young children entering this system steadily increases. Mounting evidence suggests that participation in at least some types of ECE can mitigate the need for child welfare supervision. Moreover, ECE participation has been linked to positive developmental and school readiness outcomes, lower rates of foster placement, and greater placement stability for children in the CWS...
May 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29540111/sex-differences-in-school-safety-and-bullying-experiences-among-sexual-minority-youth
#18
India D Rose, Ganna Sheremenko, Catherine N Rasberry, Catherine A Lesesne, Susan N Hocevar Adkins
Schools play an integral role in creating safe, supportive environments for students, especially for sexual minority youth (SMY). Using 2016 questionnaire data from seven high schools in a Florida school district, we obtained a sample of 1,364 SMY. Logistic regressions controlling for sex (as applicable), age, grade, race/ethnicity, and school explored differences between SMY and nonsexual minority youth (non-SMY). Sex differences related to school environment perceptions and experiences related to safety, bullying, and hearing homophobic remarks were also explored...
January 1, 2018: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/29525303/molecular-characterization-of-non-aureus-staphylococcus-spp-from-heifer-intramammary-infections-and-body-sites
#19
P R F Adkins, S Dufour, J N Spain, M J Calcutt, T J Reilly, G C Stewart, J R Middleton
The purpose of this study was to investigate non-aureus Staphylococcus spp. intramammary infections (IMI) in periparturient heifers and determine the relationship of precalving body site isolation with precalving IMI and postcalving IMI using molecular speciation and strain-typing methods. Primiparous heifers were enrolled at approximately 14 d before expected calving date. Precalving mammary quarter secretions and body site swabbing samples (teat skin, inguinal skin, muzzle, and perineum) were collected. Postcalving, mammary quarter milk samples were collected for culture and somatic cell counting...
March 7, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29514482/decision-making-on-a-deadline-tracheostomy-nutrition-and-autonomy
#20
Steven J Baumrucker, Matt Stolick, Laura Hutchinson, Gregg VandeKieft, Angela Cullop, Ella Farida Meade, Russell W Adkins
No abstract text is available yet for this article.
January 1, 2018: American Journal of Hospice & Palliative Care
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