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India D Rose, Ganna Sheremenko, Catherine N Rasberry, Catherine A Lesesne, Susan N Hocevar Adkins
Schools play an integral role in creating safe, supportive environments for students, especially for sexual minority youth (SMY). Using 2016 questionnaire data from seven high schools in a Florida school district, we obtained a sample of 1,364 SMY. Logistic regressions controlling for sex (as applicable), age, grade, race/ethnicity, and school explored differences between SMY and nonsexual minority youth (non-SMY). Sex differences related to school environment perceptions and experiences related to safety, bullying, and hearing homophobic remarks were also explored...
January 1, 2018: Journal of School Nursing: the Official Publication of the National Association of School Nurses
P R F Adkins, S Dufour, J N Spain, M J Calcutt, T J Reilly, G C Stewart, J R Middleton
The purpose of this study was to investigate non-aureus Staphylococcus spp. intramammary infections (IMI) in periparturient heifers and determine the relationship of precalving body site isolation with precalving IMI and postcalving IMI using molecular speciation and strain-typing methods. Primiparous heifers were enrolled at approximately 14 d before expected calving date. Precalving mammary quarter secretions and body site swabbing samples (teat skin, inguinal skin, muzzle, and perineum) were collected. Postcalving, mammary quarter milk samples were collected for culture and somatic cell counting...
March 7, 2018: Journal of Dairy Science
Steven J Baumrucker, Matt Stolick, Laura Hutchinson, Gregg VandeKieft, Angela Cullop, Ella Farida Meade, Russell W Adkins
No abstract text is available yet for this article.
January 1, 2018: American Journal of Hospice & Palliative Care
Jane L Tarry-Adkins, Catherine E Aiken, Thomas J Ashmore, Susan E Ozanne
Developmental programming phenotypes can be recapitulated in subsequent generations not directly exposed to the initial suboptimal intrauterine environment. A maternal low-protein diet during pregnancy and postnatal catch-up growth ('recuperated') alters insulin signaling and inflammation in rat offspring (F1-generation). We aimed to establish if this phenotype is also present in F2-generation females. Insulin-receptor-substrate-1 protein expression was decreased in para-ovarian adipose tissue at 3 months in offspring exposed to a grand-maternal low-protein diet (F2-recuperated), vs...
March 5, 2018: Scientific Reports
Margaret Disselkamp, David Adkins, Subodh Pandey, Angel O Coz Yataco
No abstract text is available yet for this article.
March 2018: Annals of the American Thoracic Society
B D Adkins, A B Barlow, A Jack, S J Schultenover, M M Desouki, A C Coogan, V L Weiss
INTRODUCTION: The characteristic features of Papanicolaou (Pap) tests collected from female-to-male (FTM) transgender patients on androgen therapy have not been well defined in the literature. FTM transgender patients require cervical cancer screening with the same recommended frequency as cis-gender females. Dysplasia remains challenging to differentiate from atrophy. Without pertinent history, the atrophic findings in younger transgender patients can be misinterpreted as high-grade dysplasia...
February 28, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Jikang Wu, Anice Sabag-Daigle, Mikayla A Borton, Linnea F M Kop, Blake E Szkoda, Brooke L Deatherage Kaiser, Stephen R Lindemann, Ryan S Renslow, Siwei Wei, Carrie D Nicora, Karl K Weitz, Young-Mo Kim, Joshua N Adkins, Thomas O Metz, Prosper Boyaka, Venkat Gopalan, Kelly C Wrighton, Vicki H Wysocki, Brian M M Ahmer
Salmonella enterica elicits intestinal inflammation to gain access to nutrients. One of these nutrients is fructose-asparagine (F-Asn). The availability of F-Asn to Salmonella during infection is dependent upon the pathogenicity islands, SPI1 and SPI2, which in turn are required to provoke inflammation. Here, we determined that F-Asn is present in mouse chow at approximately 400 pmol/mg dry weight. F-Asn is also present in the intestinal tract of germ-free mice at 2700 pmol/mg dry weight, and in the intestinal tract of conventional mice at 15 pmol/mg...
February 26, 2018: Infection and Immunity
L Adamczyk, J R Adams, J K Adkins, G Agakishiev, M M Aggarwal, Z Ahammed, N N Ajitanand, I Alekseev, D M Anderson, R Aoyama, A Aparin, D Arkhipkin, E C Aschenauer, M U Ashraf, A Attri, G S Averichev, X Bai, V Bairathi, K Barish, A Behera, R Bellwied, A Bhasin, A K Bhati, P Bhattarai, J Bielcik, J Bielcikova, L C Bland, I G Bordyuzhin, J Bouchet, J D Brandenburg, A V Brandin, D Brown, I Bunzarov, J Butterworth, H Caines, M Calderón de la Barca Sánchez, J M Campbell, D Cebra, I Chakaberia, P Chaloupka, Z Chang, N Chankova-Bunzarova, A Chatterjee, S Chattopadhyay, X Chen, J H Chen, X Chen, J Cheng, M Cherney, W Christie, G Contin, H J Crawford, S Das, L C De Silva, T G Dedovich, J Deng, A A Derevschikov, L Didenko, C Dilks, X Dong, J L Drachenberg, J E Draper, L E Dunkelberger, J C Dunlop, L G Efimov, N Elsey, J Engelage, G Eppley, R Esha, S Esumi, O Evdokimov, J Ewigleben, O Eyser, R Fatemi, S Fazio, P Federic, P Federicova, J Fedorisin, Z Feng, P Filip, E Finch, Y Fisyak, C E Flores, J Fujita, L Fulek, C A Gagliardi, D Garand, F Geurts, A Gibson, M Girard, D Grosnick, D S Gunarathne, Y Guo, A Gupta, S Gupta, W Guryn, A I Hamad, A Hamed, A Harlenderova, J W Harris, L He, S Heppelmann, S Heppelmann, A Hirsch, S Horvat, X Huang, B Huang, T Huang, H Z Huang, T J Humanic, P Huo, G Igo, W W Jacobs, A Jentsch, J Jia, K Jiang, S Jowzaee, E G Judd, S Kabana, D Kalinkin, K Kang, D Kapukchyan, K Kauder, H W Ke, D Keane, A Kechechyan, Z Khan, D P Kikoła, C Kim, I Kisel, A Kisiel, L Kochenda, M Kocmanek, T Kollegger, L K Kosarzewski, A F Kraishan, L Krauth, P Kravtsov, K Krueger, N Kulathunga, L Kumar, J Kvapil, J H Kwasizur, R Lacey, J M Landgraf, K D Landry, J Lauret, A Lebedev, R Lednicky, J H Lee, C Li, X Li, Y Li, W Li, J Lidrych, T Lin, M A Lisa, P Liu, H Liu, Y Liu, F Liu, T Ljubicic, W J Llope, M Lomnitz, R S Longacre, S Luo, X Luo, Y G Ma, L Ma, R Ma, G L Ma, N Magdy, R Majka, D Mallick, S Margetis, C Markert, H S Matis, K Meehan, J C Mei, Z W Miller, N G Minaev, S Mioduszewski, D Mishra, S Mizuno, B Mohanty, M M Mondal, D A Morozov, M K Mustafa, Md Nasim, T K Nayak, J M Nelson, M Nie, G Nigmatkulov, T Niida, L V Nogach, T Nonaka, S B Nurushev, G Odyniec, A Ogawa, K Oh, V A Okorokov, D Olvitt, B S Page, R Pak, Y Pandit, Y Panebratsev, B Pawlik, H Pei, C Perkins, P Pile, J Pluta, K Poniatowska, J Porter, M Posik, N K Pruthi, M Przybycien, J Putschke, H Qiu, A Quintero, S Ramachandran, R L Ray, R Reed, M J Rehbein, H G Ritter, J B Roberts, O V Rogachevskiy, J L Romero, J D Roth, L Ruan, J Rusnak, O Rusnakova, N R Sahoo, P K Sahu, S Salur, J Sandweiss, M Saur, J Schambach, A M Schmah, W B Schmidke, N Schmitz, B R Schweid, J Seger, M Sergeeva, R Seto, P Seyboth, N Shah, E Shahaliev, P V Shanmuganathan, M Shao, A Sharma, M K Sharma, W Q Shen, S S Shi, Z Shi, Q Y Shou, E P Sichtermann, R Sikora, M Simko, S Singha, M J Skoby, N Smirnov, D Smirnov, W Solyst, L Song, P Sorensen, H M Spinka, B Srivastava, T D S Stanislaus, M Strikhanov, B Stringfellow, A A P Suaide, T Sugiura, M Sumbera, B Summa, Y Sun, X M Sun, X Sun, B Surrow, D N Svirida, Z Tang, A H Tang, A Taranenko, T Tarnowsky, A Tawfik, J Thäder, J H Thomas, A R Timmins, D Tlusty, T Todoroki, M Tokarev, S Trentalange, R E Tribble, P Tribedy, S K Tripathy, B A Trzeciak, O D Tsai, T Ullrich, D G Underwood, I Upsal, G Van Buren, G van Nieuwenhuizen, A N Vasiliev, F Videbæk, S Vokal, S A Voloshin, A Vossen, G Wang, Y Wang, F Wang, Y Wang, J C Webb, G Webb, L Wen, G D Westfall, H Wieman, S W Wissink, R Witt, Y Wu, Z G Xiao, G Xie, W Xie, J Xu, Z Xu, Q H Xu, Y F Xu, N Xu, S Yang, Y Yang, C Yang, Q Yang, Z Ye, Z Ye, L Yi, K Yip, I-K Yoo, N Yu, H Zbroszczyk, W Zha, Z Zhang, J B Zhang, J Zhang, S Zhang, Y Zhang, X P Zhang, J Zhang, S Zhang, J Zhao, C Zhong, C Zhou, L Zhou, X Zhu, Z Zhu, M Zyzak
Rapidity-odd directed-flow measurements at midrapidity are presented for Λ, Λ[over ¯], K^{±}, K_{s}^{0}, and ϕ at sqrt[s_{NN}]=7.7, 11.5, 14.5, 19.6, 27, 39, 62.4, and 200 GeV in Au+Au collisions recorded by the Solenoidal Tracker detector at the Relativistic Heavy Ion Collider. These measurements greatly expand the scope of data available to constrain models with differing prescriptions for the equation of state of quantum chromodynamics. Results show good sensitivity for testing a picture where flow is assumed to be imposed before hadron formation and the observed particles are assumed to form via coalescence of constituent quarks...
February 9, 2018: Physical Review Letters
Ali Alawieh, E Farris Langley, Shannon Weber, DeAnna Adkins, Stephen Tomlinson
The complement system is implicated in promoting acute secondary injury after traumatic brain injury (TBI), but its role in chronic post-traumatic neuropathology remains unclear. Using various injury-site targeted complement inhibitors that block different complement pathways and activation products, we investigated how complement is involved in neurodegeneration and chronic neuroinflammation after TBI in a clinically relevant setting of complement inhibition. The current paradigm is that complement propagates post-TBI neuropathology predominantly through the terminal membrane attack complex (MAC), but the focus has been on acute outcomes...
February 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Sattva S Neelapu, Sudhakar Tummala, Partow Kebriaei, William Wierda, Frederick L Locke, Yi Lin, Nitin Jain, Naval Daver, Alison M Gulbis, Sherry Adkins, Katayoun Rezvani, Patrick Hwu, Elizabeth J Shpall
No abstract text is available yet for this article.
February 13, 2018: Nature Reviews. Clinical Oncology
Kara Bischoff, Eleanor Yang, Gayle Kojimoto, Nancy Shepard Lopez, Sarah Holland, Brook Calton, Sarah H Adkins, Stephanie Cheng, Bruce J Miller, Michael W Rabow
BACKGROUND: Outpatient palliative care (PC) has been shown to positively impact quality of life and decrease healthcare utilization, but there are limited data describing what activities render these benefits. OBJECTIVE: Describe the topics addressed by an outpatient PC team during scheduled visits. DESIGN: Longitudinal cohort study. SETTING: The Symptom Management Service, an ambulatory PC program at an academic comprehensive cancer center...
February 12, 2018: Journal of Palliative Medicine
Winnie S Liang, Kristi Stephenson, Jonathan Adkins, Austin Christofferson, Adrienne Helland, Lori Cuyugan, Jonathan J Keats
Whole exome sequencing (WES) is a DNA sequencing strategy that provides a survey of base substitutions across coding genomic locations and other regions of interest. As the coding portion of the genome encompasses only 1-2% of the entire genome, this approach represents a more cost-effective strategy to detect DNA alterations that may alter protein function, compared to whole genome sequencing. Although the research community has and is currently delineating the functional implications of sequence changes in noncoding regions of the genome, WES is a currently available assay that provides valuable information for both discovery research and precision medicine applications...
2018: Methods in Molecular Biology
Jonathan J Keats, Lori Cuyugan, Jonathan Adkins, Winnie S Liang
With the rapid evolution of genomics technologies over the past decade, whole genome sequencing (WGS) has become an increasingly accessible tool in biomedical research. WGS applications include analysis of genomic DNA from single individuals, multiple related family members, and tumor/normal samples from the same patient in the context of oncology. A number of different modalities are available for performing WGS; this chapter focuses on wet lab library construction procedures for complex short insert WGS libraries using the KAPA Hyper Prep Kit (Kapa Biosystems), and includes a discussion of appropriate quality control measures for sequencing on the Illumina HiSeq2000 platform...
2018: Methods in Molecular Biology
Irena Adkins, Nada Hradilova, Ondrej Palata, Lenka Sadilkova, Lenka Palova-Jelinkova, Radek Spisek
High hydrostatic pressure (HHP) has been known to affect biological systems for >100 years. In this review, we describe the technology of HHP and its effect macromolecules and physiology of eukaryotic cells. We discuss the use of HHP in cancer immunotherapy to kill tumor cells for generation of whole cell and dendritic cell-based vaccines. We further summarize the current use and perspectives of HHP application in biomedicine, specifically in orthopedic surgery and for the viral, microbial and protozoan inactivation to develop vaccines against infectious diseases...
January 30, 2018: Biotechnology Advances
Rena Yadlapati, Jenna Craft, Christopher J Adkins, John E Pandolfino
No abstract text is available yet for this article.
January 30, 2018: Clinical Gastroenterology and Hepatology
Jeanne E Savage, Jessica E Salvatore, Fazil Aliev, Alexis C Edwards, Matthew Hickman, Kenneth S Kendler, John Macleod, Antti Latvala, Anu Loukola, Jaakko Kaprio, Richard J Rose, Grace Chan, Victor Hesselbrock, Bradley T Webb, Amy Adkins, Tim B Bigdeli, Brien P Riley, Danielle M Dick
BACKGROUND: Despite consistent evidence of the heritability of alcohol use disorders (AUDs), few specific genes with an etiological role have been identified. It is likely that AUDs are highly polygenic; however, the etiological pathways and genetic variants involved may differ between populations. The aim of this study was thus to evaluate whether aggregate genetic risk for AUDs differed between clinically ascertained and population-based epidemiological samples. METHODS: Four independent samples were obtained: 2 from unselected birth cohorts (Avon Longitudinal Study of Parents and Children [ALSPAC], N = 4,304; FinnTwin12 [FT12], N = 1,135) and 2 from families densely affected with AUDs, identified from treatment-seeking patients (Collaborative Study on the Genetics of Alcoholism, N = 2,097; Irish Affected Sib Pair Study of Alcohol Dependence, N = 706)...
February 5, 2018: Alcoholism, Clinical and Experimental Research
P R F Adkins, S Dufour, J N Spain, M J Calcutt, T J Reilly, G C Stewart, J R Middleton
The purpose of this study was to describe the prevalence and distribution of staphylococcal species on the teat and inguinal skin of dairy heifers across the various stages of the heifer life cycle. The cross-sectional study included 106 Holstein heifers with an age range of 0 d to 27 mo that were selected from 11 different groups, based on housing type and age, on a single dairy operation. A composite swabbing sample including all 4 teats and a second composite sample including both inguinal regions of each heifer were collected using gas-sterilized electrostatic dusters (Swiffers; Procter and Gamble, Cincinnati, OH)...
January 31, 2018: Journal of Dairy Science
Karrie A Shogren, Leslie A Shaw, Sheida K Raley, Michael L Wehmeyer, Ryan M Niemiec, Megan Adkins
This article reports the results of an examination of the endorsement, reliability, and factorial validity of the VIA-Youth and assessment of character strengths and virtues developed for the general population in youth with and without intellectual disability. Findings suggest that, generally, youth with intellectual disability endorsed character strengths as being like them at lower levels, although few differences were significant. Issues related to measurement, particularly the establishment of measurement invariance, emerged for some virtues...
February 2018: Intellectual and Developmental Disabilities
Antonio Aguayo, Camille S Martin, Timothy F Huddy, Maya Ogawa-Okada, Jamie L Adkins, Andrew D Steele
Recent studies in mice have demonstrated a sexual dimorphism in circadian entrainment to scheduled feeding. On a time restricted diet, males tend to develop food anticipatory activity (FAA) sooner than females and with a higher amplitude of activity. The underlying cause of this sex difference remains unknown. One study suggests that sex hormones, both androgens and estrogens, modulate food anticipatory activity in mice. Here we present results suggesting that the sex difference in FAA is unrelated to gonadal sex hormones...
2018: PloS One
Kristine Song, Amit Chakraborty, Matthew Dawson, Adam Dugan, Brian Adkins, Christopher Doty
Introduction: Medical education is a rapidly evolving field that has been using new technology to improve how medical students learn. One of the recent implementations in medical education is the recording of lectures for the purpose of playback at various speeds. Though previous studies done via surveys have shown a subjective increase in the rate of knowledge acquisition when learning from sped-up lectures, no quantitative studies have measured information retention. The purpose of this study was to compare mean test scores on written assessments to objectively determine if watching a video of a recorded lecture at 1...
January 2018: Western Journal of Emergency Medicine
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