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https://www.readbyqxmd.com/read/29352207/ethanol-sensitizes-hepatocytes-for-tgf-%C3%AE-triggered-apoptosis
#1
Haristi Gaitantzi, Christoph Meyer, Pia Rakoczy, Maria Thomas, Kristin Wahl, Franziska Wandrer, Heike Bantel, Hamed Alborzinia, Stefan Wölfl, Sabrina Ehnert, Andreas Nüssler, Ina Bergheim, Loredana Ciuclan, Matthias Ebert, Katja Breitkopf-Heinlein, Steven Dooley
Alcohol abuse is a global health problem causing a substantial fraction of chronic liver diseases. Abundant TGF-β-a potent pro-fibrogenic cytokine-leads to disease progression. Our aim was to elucidate the crosstalk of TGF-β and alcohol on hepatocytes. Primary murine hepatocytes were challenged with ethanol and TGF-β and cell fate was determined. Fluidigm RNA analyses revealed transcriptional effects that regulate survival and apoptosis. Mechanistic insights were derived from enzyme/pathway inhibition experiments and modulation of oxidative stress levels...
January 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29351758/autophagy-promotes-metastasis-and-glycolysis-by-upregulating-mct1-expression-and-wnt-%C3%AE-catenin-signaling-pathway-activation-in-hepatocellular-carcinoma-cells
#2
Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Yan Li, Lei Dong, Zhihong Zong, Xiangdong Hua, Dongming Su, Hangyu Li, Jingang Liu
BACKGROUND: Autophagy is a dynamic physiological process that can generate energy and nutrients for cell survival during stress. Autophagy can regulate the migration and invasive ability in cancer cells. However, the connection between autophagy and metabolism is unclear. Monocarboxylate transporter 1 (MCT1) plays an important role in lactic acid transport and H+ clearance in cancer cells, and Wnt/β-catenin signaling can increase cancer cell glycolysis. We investigated whether autophagy promotes glycolysis in hepatocellular carcinoma (HCC) cells by activating the Wnt/β-catenin signaling pathway, accompanied by MCT1 upregulation...
January 19, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29348818/high-cyp2e1-activity-correlates-with-hepatofibrogenesis-induced-by-nitrosamines
#3
Jie Gao, Gao-Ju Wang, Zhao Wang, Na Gao, Jing Li, Yun-Fei Zhang, Jun Zhou, Hong-Xin Zhang, Qiang Wen, Han Jin, Hai-Ling Qiao
Hepatofibrosis, which leads to cirrhosis and eventual hepatocellular carcinoma, is a common response to chronic toxin-mediated liver injury. Nitrosamines are potent hepatotoxic agents that cause necrosis and subsequent fibrosis in the liver as a result of cytochrome P450 2E1 (CYP2E1)-dependent metabolism, which generates toxic metabolites that form adducts with nucleic acids, leading to hepatotoxicity and mutagenesis. Herein, CYP2E1 activity and content were determined in fibrotic liver tissue from patients with hepatocellular carcinoma...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29335523/mir-139-5p-inhibits-aerobic-glycolysis-cell-proliferation-migration-and-invasion-in-hepatocellular-carcinoma-via-a-reciprocal-regulatory-interaction-with-ets1
#4
Shengni Hua, Ling Lei, Ling Deng, Xie Weng, Chengdong Liu, Xiaolong Qi, Shuang Wang, Dongyan Zhang, Xuejing Zou, Chuanhui Cao, Li Liu, Dehua Wu
Cancer cells have metabolic features that allow them to preferentially metabolize glucose through aerobic glycolysis, providing them with a progression advantage. However, microRNA (miRNA) regulation of aerobic glycolysis in cancer cells has not been extensively investigated. We addressed this in the present study by examining the regulation of miR-139-5p on aerobic glycolysis of hepatocellular carcinoma (HCC) using clinical specimens, HCC cells, and a mouse xenograft model. We found that overexpressing miR-139-5p restrained aerobic glycolysis, suppressing proliferation, migration, and invasion in HCC cells...
January 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29335519/metabolic-reprogramming-by-pck1-promotes-tca-cataplerosis-oxidative-stress-and-apoptosis-in-liver-cancer-cells-and-suppresses-hepatocellular-carcinoma
#5
Meng-Xi Liu, Lei Jin, Si-Jia Sun, Peng Liu, Xu Feng, Zhou-Li Cheng, Wei-Ren Liu, Kun-Liang Guan, Ying-Hong Shi, Hai-Xin Yuan, Yue Xiong
Phosphoenolpyruvate carboxykinase (PEPCK or PCK) catalyzes the first rate-limiting step in hepatic gluconeogenesis pathway to maintain blood glucose levels. Mammalian cells express two PCK genes, encoding for a cytoplasmic (PCPEK-C or PCK1) and a mitochondrial (PEPCK-M or PCK2) isoforms, respectively. Increased expressions of both PCK genes are found in cancer of several organs, including colon, lung, and skin, and linked to increased anabolic metabolism and cell proliferation. Here, we report that the expressions of both PCK1 and PCK2 genes are downregulated in primary hepatocellular carcinoma (HCC) and low PCK expression was associated with poor prognosis in patients with HCC...
January 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29330507/uncovering-the-anticancer-mechanism-of-compound-kushen-injection-against-hcc-by-integrating-quantitative-analysis-network-analysis-and-experimental-validation
#6
Li Gao, Ke-Xin Wang, Yu-Zhi Zhou, Jian-Song Fang, Xue-Mei Qin, Guan-Hua Du
Compound Kushen Injection (CKI) is a Traditional Chinese Medicine (TCM) preparation that has been clinically used in China to treat various types of solid tumours. Although several studies have revealed that CKI can inhibit the proliferation of hepatocellular carcinoma (HCC) cell lines, the active compounds, potential targets and pathways involved in these effects have not been systematically investigated. Here, we proposed a novel idea of "main active compound-based network pharmacology" to explore the anti-cancer mechanism of CKI...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328457/microrna%C3%A2-34a-inhibits-liver-cancer-cell-growth-by-reprogramming-glucose-metabolism
#7
Hai-Feng Zhang, Yi-Cheng Wang, Yi-Di Han
MicroRNAs (miRs) have been proposed as minimally invasive prognostic markers for various types of cancer, including liver cancer, which is one of the most common cancers worldwide. In the present study, the expression of miR‑34a in human liver cancer tissues and cell lines was evaluated and the effects of miR‑34a on cell proliferation, invasion and glycolysis in hepatocellular carcinoma (HCC) cells were determined. The results indicated that miR‑34a was downregulated in human liver cancer tissues. Overexpression of miR‑34a significantly inhibited liver cancer cell proliferation and clone formation...
January 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29327320/phylogenetic-analysis-and-biological-evaluation-of-marine-endophytic-fungi-derived-from-red-sea-sponge-hyrtios-erectus
#8
Mervat Morsy Abbas Ahmed El-Gendy, Shaymaa M M Yahya, Ahmed R Hamed, Maha M Soltan, Ahmed Mohamed Ahmed El-Bondkly
Forty-four endophytic fungal isolates obtained from marine sponge, Hyrtios erectus, were evaluated and screened for their hydrolase activities. Most of the isolates were found to be prolific producers of hydrolytic enzymes. Only 11 isolates exhibited maximum cellular contents of lipids, rhamnolipids, and protein in the fungal isolates under the isolation numbers MERVA5, MERVA22, MERVA25, MERVA29, MERVA32, MERVA34, MERV36, MERVA39, MERVA42, MERVA43, and MERVA44. These isolate extracts exhibit the highest reducing activities against carbohydrate-metabolizing enzymes including α-amylase, α-glucosidase, β-glucosidase, β-glucuronidase, and tyrosinase...
January 12, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29325602/bile-acid-metabolism-in-liver-pathobiology
#9
John Y L Chiang, Jessica M Ferrell
Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain bile acid homeostasis, which is essential for protecting liver and other tissues and cells from cholesterol and bile acid toxicity. Bile acid metabolism is tightly regulated by bile acid synthesis in the liver and bile acid biotransformation in the intestine. Bile acids are endogenous ligands that activate a complex network of nuclear receptor farnesoid X receptor and membrane G protein-coupled bile acid receptor-1 to regulate hepatic lipid and glucose metabolic homeostasis and energy metabolism...
January 11, 2018: Gene Expression
https://www.readbyqxmd.com/read/29322794/integrated-analysis-of-the-rna-seq-data-of-liver-hepatocellular-carcinoma
#10
H Xue, L Luo, Y T Yao, L L Wei, S P Deng, X L Huang
The present study aimed to explore the genetic changes involved in the liver hepatocellular carcinoma (HCC) development. The RNA-Seq data of 212 HCC tissue samples and 50 normal tissue samples were downloaded using TCGA-Assembler. A total of 4 subgroups were obtained, and 4167, 6279, 5379, and 2548 DEGs were screened in group 1, group 2, group 3, and group 4, respectively. Enrichment analysis found that cell cycle, metabolism, and translation related terms were the most significantly changed functions and pathways...
2018: Neoplasma
https://www.readbyqxmd.com/read/29321577/8u-a-pro-apoptosis-cell-cycle-arrest-compound-suppresses-invasion-and-metastasis-through-hsp90%C3%AE-downregulating-and-pi3k-akt-inactivation-in-hepatocellular-carcinoma-cells
#11
Ning Wang, Shaopeng Chen, Bin Zhang, Shangfu Li, Feng Jin, Dan Gao, Hongxia Liu, Yuyang Jiang
8u, an acridine derivative, has been proved effective anti-hepatocarcinoma effect, while the underlying mechanism remains unclear. Here, metabolomics and proteomics approaches were applied to study its anti-cancer mechanism and explore its effect on HepG2 cells' invasion and metastasis abilities. The results showed that 8u significantly suppressed HepG2 cells migration and enhanced cell-to-cell junctions. The inhibition effect of 8u on invasion and metastasis disappeared after HSP90α gene silencing, and was reversed after HSP90α overexpression...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317174/elective-endoscopic-variceal-ligation-is-not-a-risk-factor-for-bacterial-infection-in-patients-with-liver-cirrhosis
#12
Sergio Maimone, Francesca Saffioti, Roberto Filomia, Gaia Caccamo, Carlo Saitta, Socrate Pallio, Pierluigi Consolo, Sara Sabatini, Krizia Sitajolo, Maria Stella Franzè, Irene Cacciola, Giovanni Raimondo, Giovanni Squadrito
BACKGROUND: Patients with cirrhosis are at high risk of bacterial infections. Invasive procedures are generally believed to increase this susceptibility. AIMS: We investigated the incidence of bacterial infections in cirrhotic patients undergoing elective endoscopic variceal ligation (EVL). METHODS: We enrolled 60 consecutive cirrhotic patients who underwent a total number of 112 elective EVL procedures. One to seven bands were applied at each session until variceal eradication...
December 20, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29311419/radiogenomics-of-hepatocellular-carcinoma-multiregion-analysis-based-identification-of-prognostic-imaging-biomarkers-by-integrating-gene-data-a-preliminary-study
#13
Wei Xia, Ying Chen, Rui Zhang, Zhuangzhi Yan, Xiaobo Zhou, Bo Zhang, Xin Gao
To identify prognostic imaging biomarkers for hepatocellular carcinoma (HCC) in contrast-enhanced computed tomography (CECT) with biological interpretations by associating imaging features and gene modules. We retrospectively analyzed 371 patients who had gene expression profiles. For the 38 patients with CECT imaging data, automatic intra-tumor partition was performed resulting in three spatially distinct subregions. We extracted totally 37 quantitative imaging features describing intensity, geometry, and texture from each subregion...
January 9, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29303508/glutamine-synthetase-mediates-sorafenib-sensitivity-in-%C3%AE-catenin-active-hepatocellular-carcinoma-cells
#14
Bo Hwa Sohn, In Young Park, Ji-Hyun Shin, Sun Young Yim, Ju-Seog Lee
The gene encoding β-catenin is frequently mutated in hepatocellular carcinoma cells. While the oncogenicity of β-catenin has been extensively studied, β-catenin's role in hepatocellular carcinoma tumor metabolism is currently less well understood. In this study, we found that β-catenin regulates the expression of glutamine synthetase and triggers a series of metabolic changes leading to induction of autophagy in hepatocellular carcinoma cells. β-Catenin-active Hep3B and HepG2 cells exhibited higher basal levels of autophagic activity than did β-catenin wild-type cells...
January 5, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29296233/srebp-2-driven-transcriptional-activation-of-human-snd1-oncogene
#15
Sandra Armengol, Enara Arretxe, Leire Enzunza, Irati Llorente, Unai Mendibil, Hiart Navarro-Imaz, Begoña Ochoa, Yolanda Chico, María José Martínez
Upregulation of Staphylococcal nuclease and tudor domain containing 1 (SND1) is linked to cancer progression and metastatic spread. Increasing evidence indicates that SND1 plays a role in lipid homeostasis. Recently, it has been shown that SND1-overexpressing hepatocellular carcinoma cells present an increased de novo cholesterol synthesis and cholesteryl ester accumulation. Here we reveal that SND1 oncogene is a novel target for SREBPs. Exposure of HepG2 cells to the cholesterol-lowering drug simvastatin or to a lipoprotein-deficient medium triggers SREBP-2 activation and increases SND1 promoter activity and transcript levels...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29291263/overexpression-of-anthocyanidin-synthase-ans-gene-in-strawberry-enhances-antioxidant-capacity-and-cytotoxic-effects-on-human-hepatic-cancer-cells
#16
Francesca Giampieri, Massimiliano Gasparrini, Tamara Yuliett Forbes-Hernandez, Luca Mazzoni, Franco Capocasa, Silvia Sabbadini, José M Alvarez-Suarez, Sadia Afrin, Carlo Rosati, Tiziana Pandolfini, Barbara Molesini, José F Sanchez-Villa, Iraida Amaya, Bruno Mezzetti, Maurizio Battino
Food fortification through the increase and/or modulation of bioactive compounds has become a major goal for preventing several diseases, including cancer. Here, strawberry lines of cv. Calypso transformed with a construct containing an anthocyanidin synthase (ANS) gene were produced to study the effects on anthocyanin biosynthesis, metabolism and transcriptome. Three strawberry ANS transgenic lines (ANS L5, ANS L15 and ANS L18) were analysed for phytochemical composition and total antioxidant capacity (TAC), and their fruit extracts assessed for cytotoxic effects on hepatocellular carcinoma...
January 1, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29288082/octyl-gallate-reduces-atp-levels-and-ki67-expression-leading-hepg2-cells-to-cell-cycle-arrest-and-mitochondria-mediated-apoptosis
#17
Kelly Goulart Lima, Gabriele Catyana Krause, Elisa Feller Gonçalves da Silva, Léder Leal Xavier, Leo Anderson Meira Martins, Laura Manzoli Alice, Luiza Bueno da Luz, Rodrigo Benedetti Gassen, Eduardo Cremonese Filippi-Chiela, Gabriela Viegas Haute, Maria Claudia Rosa Garcia, Giselle Afonso Funchal, Leonardo Pedrazza, Camille Kirinus Reghelin, Jarbas Rodrigues De Oliveira
Octyl gallate (OG) is an antioxidant that has shown anti-tumor, anti-diabetic and anti-amyloidogenic activities. Mitochondria play an important role in hepatocellular carcinoma, mainly by maintaining accelerated cellular proliferation through the production of ATP. Thus, the mitochondria may be a target for antitumor therapies. Here, we investigated the effects of OG in the hepatocarcinoma cell line (HepG2) and the mechanisms involved. We report, for the first time, that treatment with OG for 24h inhibited HepG2 cell growth by decreasing mitochondrial activity and mass, which led to the reduction of ATP levels...
December 26, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29285212/tumor-suppressive-effect-of-s-adenosylmethionine-supplementation-in-a-murine-model-of-inflammation-mediated-hepatocarcinogenesis-is-dependent-on-treatment-longevity
#18
Evgeniy Stoyanov, Lina Mizrahi, Devorah Olam, Temima Schnitzer-Perlman, Eithan Galun, Daniel S Goldenberg
Chronic inflammation precedes the majority of hepatocellular carcinoma (HCC) cases. We investigated the chemopreventive potential of S-adenosylmethionine (SAM), an essential donor for all methylation reactions in the cell, at the late precancerous stage of HCC development using the Mdr2-knockout (Mdr2-KO, Abcb4-/-) mice, a model of inflammation-mediated hepatocarcinogenesis. Previously, we revealed down-regulation of the genes regulating SAM metabolism in the liver of these mice at the precancerous stages. Now, we have supplied Mdr2-KO mice at the late precancerous stage with SAM during either a short-term (17 days) or a long-term (51 days) period and explored the effects of such supplementation on tumor development, DNA methylation and gene expression in the liver...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29283330/mirna-in-hepatocellular-carcinoma-pathogenesis-and-therapeutic-approaches
#19
Muhammad Imran Qadir, Samana Zahra Rizvi
Hepatocellular carcinoma (HCC) is a worldwide disease. Because therapeutic measures are ineffective, HCC currently has a poor prognosis. The main causes of HCCs are alcoholism, hepatitis, and metabolic syndrome. Normally hygieinic studies revealed that there is lower survival rate of HCC. MicroRNAs (miRNAs) consist of short noncoding sequences of RNA (20 to 24 nucleotides), which posttranscriptionally regulate the expression of the protein coding genes. MicroRNAs have been proposed to be prospective therapeutic molecules and targets...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29280623/metabolism-of-a-phenylarsenical-in-human-hepatic-cells-and-identification-of-a-new-arsenic-metabolite
#20
Qingqing Liu, Elaine M Leslie, Birget Moe, Hongquan Zhang, Donna N Douglas, Norman M Kneteman, X Chris Le
Environmental contamination and human consumption of chickens could result in potential exposure to Roxarsone (3-nitro-4-hydroxyphenylarsonic acid), an organic arsenical that has been used as a chicken feed additive in many countries. However, little is known about the metabolism of Roxarsone in humans. The objective of this research was to investigate the metabolism of Roxarsone in human liver cells and to identify new arsenic metabolites of toxicological significance. Human primary hepatocytes and hepatocellular carcinoma HepG2 cells were treated with 20 or 100 µM Roxarsone...
December 27, 2017: Environmental Science & Technology
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