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Cyanoacrylate and hernia

Mar Fernández-Gutiérrez, Marta Rodriguez-Mancheño, Bárbara Pérez-Köhler, Gemma Pascual, Juan Manuel Bellón, Julio San Román
The article deals with a comparative analysis of the parameters of the polymerization in physiological conditions of three commercially available alkyl cyanoacrylates, n-butyl cyanoacrylate (GLUBRAN 2), n-hexyl cyanoacrylate (IFABOND), and n-octyl cyanoacrylate (EVOBOND), the cell behavior of the corresponding polymers and the application of these adhesives in the fixation of surgical polypropylene meshes for hernia repair in an animal model of rabbits. The results obtained demonstrate that the curing process depends on the nature of the alkyl residue of the ester group of cyanoacrylate molecules, being the heat of polymerization lower for the octyl derivative in comparison with the hexyl and butyl, and reaching a maximum temperature of 35 °C after a time of mixing with physiological fluids of 60-70 s...
October 5, 2016: Macromolecular Bioscience
Gemma Pascual, Sandra Sotomayor, Marta Rodríguez, Bárbara Pérez-Köhler, Andreé Kühnhardt, Mar Fernández-Gutiérrez, Julio San Román, Juan Manuel Bellón
BACKGROUND: Cyanoacrylate(CA)-based tissue adhesives, although not widely used, are a feasible option to fix a mesh during abdominal hernia repair, due to its fast action and great bond strength. Their main disadvantage, toxicity, can be mitigated by increasing the length of their alkyl chain. The objective was to assess the in vitro cytotoxicity and in vivo biocompatibility in hernia repair of CAs currently used in clinical practice (Glubran(n-butyl) and Ifabond(n-hexyl)) and a longer-chain CA (OCA(n-octyl)), that has never been used in the medical field...
2016: PloS One
Si Min Park, Nasser Shukri, Eun Young Chang, In Geol Ho, Seok Joo Han
PURPOSE: The aim of this study was to provide clinical evidence supporting the safety and effectiveness of laparoscopic surgical glue injection hernioplasty (LSGIH) for indirect inguinal hernia repair in female patients. METHODS: We conducted a prospective study of LSGIH beginning in January 2013. N-butyl-2-cyanoacrylate was used as the surgical glue for closure of the hernia sac. Twenty-eight female patients with a mean age of 51.1 ± 35.3 months (24 days to 10 years) received LSGIH...
June 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Kalpesh Jani
BACKGROUND: We present a randomised control trial to compare suture fixation of the mesh with non-mechanical fixation using n-butyl cyanoacrylate (NBCA) glue for laparoscopic totally extraperitoneal (TEP) hernioplasty. PATIENTS AND METHODS: After a standard dissection for laparoscopic TEP hernioplasty, the mesh was fixed using sutures or NBCA glue to the Cooper's ligament as per the randomised allocation. The primary endpoints were recurrence at 24 months and chronic groin pain...
April 2016: Journal of Minimal Access Surgery
José M Lloris-Carsí, Jaime Ballester-Álvaro, Carlos Barrios, Cristobal Zaragozá-Fernández, Carlos Gómez-De la Cruz, Chelo González-Cuartero, Beatriz Prieto-Moure, Dolores Cejalvo-Lapeña
UNLABELLED: The use of synthetic adhesives such as cyanoacrylates for closing surgical wounds remains controversial. In a multicenter, prospective and randomized clinical trial, we compared a new cyanoacrylate elastic tissue adhesive, Adhflex, with standard suturing methods for repairing surgical wounds. Sixty patients who underwent surgery for inguinal hernia were randomly chosen for Adhflex or standard silk suture. We evaluated wound closure time and parameters related to wound healing and complications using the Hollander Scale; overall surgeon, patient, and independent evaluator satisfaction with scar appearance using a visual analog scale; and scar cosmesis and cosmetic outcome using the Patient and Observer Scar Assessment Scale...
May 2016: Wound Repair and Regeneration
Kirsi Rönkä, Jaana Vironen, Jyrki Kössi, Tanja Hulmi, Seppo Silvasti, Tapio Hakala, Imre Ilves, Indrek Song, Merja Hertsi, Petri Juvonen, Hannu Paajanen
OBJECTIVE: Three different mesh fixation techniques were compared to find out how to perform a safe and cost-effective open inguinal hernioplasty in day-case setting with the best outcomes with regard to chronic pain. SUMMARY BACKGROUND DATA: Mesh fixation method may influence on the incidence of chronic pain after Lichtenstein hernioplasty. METHODS: Lichtenstein hernioplasty was performed under local anesthesia in 625 patients as day-case surgery in 8 Finnish hospitals...
November 2015: Annals of Surgery
Gurhan Bas, Orhan Veli Ozkan, Orhan Alimoglu, Ramazan Eryilmaz, Mustafa Sahin, Ismail Okan, Ugur Cevikbas
Diaphragmatic injuries either by blunt or penetrating trauma require prompt surgical intervention and are often exigent to repair. N-butyl-2-cyanoacrylate (n-butyl-2-CA) is a tissue adhesive which has gained wide application in many areas of surgery including emergency. To repair the extensive injuries of the diaphragm it may be necessary the use of synthetic mesh by fixing it with sutures or staples. The use of tissue adhesives may circumvent the potential problems associated with mesh fixation. This study aimed to evaluate the efficacy and safety of tissue adhesives usage for mesh fixation in diaphragmatic injury repair...
2015: International Journal of Clinical and Experimental Medicine
Antonio Darecchio, Paolo Bocchi, Jan F Kukleta
AIM: To achieve full-surface contact of a prosthetic mesh with the abdominal wall (avoiding folds and wrinkles) in laparoscopic ventral/ incisional hernia repair (LVHR/ LIHR) and to fix the mesh with glue using a new surgical technique and a new device, developed for this specific procedure. MATERIAL OF STUDY: New surgical technique associated with a new surgical pneumatic device allows perfect positioning and extension of the intraperitoneal mesh and facilitates the glue application and mesh fixation...
May 2015: Annali Italiani di Chirurgia
Ralf-Bodo Tröbs, M Reza Vahdad, Grigore Cernaianu
PURPOSE: We herein report a case series evaluating the safety and complication rate of transumbilical cord access (TUCA) for pediatric laparoscopic surgery. METHODS: Data were collected for 556 infants and children. Access into the abdominal cavity was gained via a transverse infraumbilical stab incision passing the fibrotic umbilical cord remnant. Ninety-two infants underwent laparoscopic pyloromyotomy (LPM), 159 female infants underwent herniorrhaphy (LHR) and 309 infants underwent appendectomy (LAP)...
February 2016: Surgery Today
Yoshiyuki Saito, Keisuke Kubota, Akihiro Okada, Tomoaki Deguchi, Junko Kuroda, Nobuhiro Nitori, Tomohisa Kadomura, Masashi Yoshida, Masaki Kitajima
PURPOSE: We developed a new technique, sutureless mesh fixation, using 2-octyl cyanoacrylate (Dermabond(®), a surgical tissue adhesive) for incisional hernia repair. The objective of this article is to introduce the new technique and to examine whether the technique provides sufficient resistance to abdominal pressure. METHODS: We conducted two tests using a porcine model, a traction experiment and artificial pneumoperitoneum test. In the traction experiment, the adherence properties of Dermabond(®) with mesh and peritoneum were examined using a tissue fragment from a pig...
April 10, 2015: Surgery Today
E Reynvoet, S Van Cleven, I Van Overbeke, K Chiers, P De Baets, R Troisi, F Berrevoet
PURPOSE: The use of glue as mesh fixation in laparoscopic ventral hernia repair (LVHR) significantly reduces fixation associated morbidity. This experiment evaluates the intraperitoneal use of synthetic glue as single mesh fixation. METHODS: A total of 21 sheep were operated using a hernia model with two fascial defects of 2 cm(2) at the linea alba. One week later two polypropylene meshes (Dynamesh®) were implanted laparoscopically, using cyanoacrylate glue (Ifabond®) or conventional fixation (Securestrap®)...
August 2015: Hernia: the Journal of Hernias and Abdominal Wall Surgery
A Burza, R Avantifiori, R Curinga, E Santini, P Delle Site, F Stipa
AIM: The aim of this retrospective study was to compare the results of two different mesh fixation methods in laparoscopic transabdominal preperitoneal hernioplasty (TAPP): tacker vs. synthetic cyanoacrylate glue. METHODS: The study group includes 70 patients with bilateral and monolateral recurrent inguinal hernia undergoing transabdominal preperitoneal repair (TAPP) in the period 2011-2013. A polypropylene mesh was fixed in group A (N.=35) with titanium tacks (EndoUniversal stapler, Covidien) or in group B (N...
December 2014: Minerva Chirurgica
Luis Garcia-Vallejo, Ivan Couto-Gonzalez, Pablo Concheiro-Coello, Beatriz Brea-Garcia, Antonio Taboada-Suarez
In an attempt to find the ideal surgical technique for mesh fixation during laparoscopic total extraperitoneal inguinal hernia repair, we evaluate the use of a synthetic surgical glue (N-butyl-cyanoacrylate-Glubran 2) in an effort to reduce postoperative pain and the complications associated with the use of staples. We have prospectively evaluated 61 consecutive patients (73 hernias) with a minimum follow-up period of 18 months and an average of 29.7 months, without any significant complications present. The majority (59%) only required low dosages of painkillers during the first 24 hours after surgery and have not experienced any cases of chronic pain or recurring hernias in the time period described...
June 2014: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
S Wu, H Yu, Y Fan, J Kong, X Yu
BACKGROUND: Liver retraction is critical in single-incision laparoscopic upper abdominal surgery. Several techniques have been reported. Some need an additional port, whereas others are complicated and time-consuming. METHODS: n-Butyl-2-cyanoacrylate (NBCA) glue was applied to bond the left lateral lobe of the liver to the diaphragm in different single-incision laparoscopic upper abdominal procedures. Liver adhesion time and duration of operation were recorded, and preoperative and postoperative liver function tests carried out...
April 2014: British Journal of Surgery
Alfredo Moreno-Egea
BACKGROUND: The morbidity linked to the use of sutures in inguinal hernioplasty is well known. Tissue adhesives may be an alternative, so as to be able to improve levels of postoperative comfort, but clinical experience using them is limited. The aim of this study is to evaluate the efficiency of cyanoacrylate as a substitute for sutures in the treatment of inguinal hernias. PATIENTS: Randomized clinical trial in abdominal wall unit. A total of 208 patients were operated upon for inguinal hernias of which 102 were unilateral hernias via open surgery using the Lichtenstein technique, randomized to receive prolene sutures (n = 52) or n-hexyl-α-cyanoacrylate glue (n = 50) and 106 were patients with bilateral inguinal hernias operated upon via totally extraperitoneal laparoscopy and randomized to receive either tackers (n = 54) or glue (n = 52)...
December 2014: Surgical Innovation
Fabrice Rossignol, Céline Mespoulhes-Rivière, Amélie Vitte, Antoine Lechartier, Karl Joseph Boening
OBJECTIVE: To describe a technique for standing inguinal hernioplasty in horses using cyanoacrylate glue, and to evaluate its effect on prevention of recurrent inguinal herniation in stallions that had previous acquired strangulated inguinal hernia (SIH). STUDY DESIGN: Case series. ANIMALS: Stallions (n = 10) with a history of SIH. METHODS: Hernioplasty was performed in standing horses using 4 laparoscopic portals. The mesorchium was retracted caudomedially using Babcock forceps...
January 2014: Veterinary Surgery: VS
Somboon Subwongcharoen, Kanchana Ruksakul
BACKGROUND: There has been paramount concern among most surgeons over complications caused by staples in the form of pubic injury and nerve entrapment leading to chronic pain in laparoscopic inguinal hernia repair OBJECTIVE: The present study aimed to compare the use of N-butyl-2-cyanoacrylate (Histoacryl) with that of staples in fixation of mesh in totally extraperitoneal laparoscopic inguinal hernia repair in terms of acute and chronic pain, complications, and recurrence within 1 year MATERIAL AND METHOD: 60 patients were allocated into 2 groups...
March 2013: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Ming-gang Wang, Mao-lin Tian, Xue-fei Zhao, Yu-sheng Nie, Jie Chen, Ying-mo Shen
BACKGROUND: Our purpose was to compare the recurrence rate and other clinical outcomes of laparoscopic (LS) transabdominal preperitoneal (TAPP) inguinal hernia repair using n-butyl-2-cyanoacrylate (NBCA) for mesh fixation with those of no mesh fixation and mesh fixation with titanium spiral tacks (ST). METHODS: The medical records of patients who received LS TAPP inguinal hernia repair between 2009 and 2012 at our institution were reviewed. Patients were included if the received LS TAPP with either no mesh fixation, mesh fixation with NBCA only, fixation with ST only, or fixation with NBCA + ST...
October 2013: Surgical Endoscopy
D L Sanders, S Waydia
PURPOSE: The technique for fixation of mesh has been attributed to adverse patient and surgical outcomes. Although this has been the subject of vigorous debate in laparoscopic hernia repair, the several methods of fixation in open, anterior inguinal hernia repair have seldom been reviewed. The aim of this systematic review was to determine whether there is any difference in patient-based (recurrence, post-operative pain, SSI, quality of life) or surgical outcomes (operative time, length of operative stay) with different fixation methods in open anterior inguinal hernioplasty...
April 2014: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Ying Fan, Shuo-Dong Wu, Jing Kong, Yang Su, Yu Tian
BACKGROUND/AIM: Single-incision laparoscopic fundoplication is not widespread because of its technical difficulty. An additional stay suture or retractor is often needed for liver retraction during the procedure. Here, we share our 7 cases to demonstrate the feasibility of transumbilical single-incision laparoscopic fundoplication with a new technique for liver retraction without any stay suture or retractor. PATIENTS AND METHODS: From March 2010 to October 2011, 3 patients with achalasia underwent a transumbilical single-incision laparoscopic Heller-Dor operation, and 4 patients with hiatus hernia underwent transumbilical single-incision laparoscopic hernioplasty and Nissen fundoplication...
April 2013: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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