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https://www.readbyqxmd.com/read/29353439/transgenesis-by-microparticle-bombardment-for-live-imaging-of-fluorescent-proteins-in-pristionchus-pacificus-germline-and-early-embryos
#1
Satoshi Namai, Asako Sugimoto
Pristionchus pacificus is a free-living nematode used as a model organism for evolutionary developmental and ecological biology. Although a transgenic technique to form complex arrays by microinjection has been established in P. pacificus, transgene expression from the array in the germline and early embryos tends to be silenced. Here, we established a method to integrate transgenes into the genome of P. pacificus using microparticle bombardment with hygromycin B selection. Additionally, we isolated a mutant exhibiting significantly lower autofluorescence in the germline and early embryos, facilitating visualization of transgene-derived fluorescent proteins for live imaging...
January 20, 2018: Development Genes and Evolution
https://www.readbyqxmd.com/read/29353384/the-effect-of-self-care-education-on-emotional-intelligence-of-iranian-nursing-students-a-quasi-experimental-study
#2
Amir Hossein Goudarzian, Masoumeh Bagheri Nesami, Parisa Sedghi, Mahsan Gholami, Maryam Faraji, Mahdi Babaei Hatkehlouei
This study aimed to determine the effect of self-care training on emotional intelligence of nursing students. This quasi-experimental study was conducted on nursing students of Mazandaran University of Medical Sciences in 2016. The subjects (60 students) that were collected with random sampling method were divided into experimental and control groups, and then, self-care behaviors were taught to the experimental group' students in 12 sessions by using a checklist. The subjects of control group were not taught...
January 20, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29353335/leveraging-model-informed-approaches-for-drug-discovery-and-development-in-the-cardiovascular-space
#3
REVIEW
Marissa F Dockendorf, Ryan C Vargo, Ferdous Gheyas, Anne S Y Chain, Manash S Chatterjee, Larissa A Wenning
Cardiovascular disease remains a significant global health burden, and development of cardiovascular drugs in the current regulatory environment often demands large and expensive cardiovascular outcome trials. Thus, the use of quantitative pharmacometric approaches which can help enable early Go/No Go decision making, ensure appropriate dose selection, and increase the likelihood of successful clinical trials, have become increasingly important to help reduce the risk of failed cardiovascular outcomes studies...
January 20, 2018: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29353320/monitoring-and-measurement-of-microalgae-using-the-first-derivative-of-absorbance-and-comparison-with-chlorophyll-extraction-method
#4
Fares A Almomani, Banu Örmeci
Monitoring of microalgae in water supplies and industrial applications are becoming increasingly important, yet there are few options available that are simple and accurate, and can provide real-time information. The present work illustrates a new method to determine the concentration of microalgae in water and wastewater using spectrophotometry and the first derivative of absorbance. Chlorella vulgaris was used as an indicator microalga, spiked in water samples representing a range of water qualities (distilled water, surface water, and wastewater), and correlations among C...
January 20, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29353316/validation-of-a-new-classification-for-periprosthetic-shoulder-fractures
#5
Chlodwig Kirchhoff, Marc Beirer, Ulrich Brunner, Arne Buchholz, Peter Biberthaler, Moritz Crönlein
INTRODUCTION: Successful treatment of periprosthetic shoulder fractures depends on the right strategy, starting with a well-structured classification of the fracture. Unfortunately, clinically relevant factors for treatment planning are missing in the pre-existing classifications. Therefore, the aim of the present study was to describe a new specific classification system for periprosthetic shoulder fractures including a structured treatment algorithm for this important fragility fracture issue...
January 20, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29353309/methods-for-enhancing-cyanobacterial-stress-tolerance-to-enable-improved-production-of-biofuels-and-industrially-relevant-chemicals
#6
REVIEW
Rebecca L Kitchener, Amy M Grunden
Cyanobacteria are photosynthetic prokaryotes that can fix atmospheric CO2 and can be engineered to produce industrially important compounds such as alcohols, free fatty acids, alkanes used in next-generation biofuels, and commodity chemicals such as ethylene or farnesene. They can be easily genetically manipulated, have minimal nutrient requirements, and are quite tolerant to abiotic stress making them an appealing alternative to other biofuel-producing microbes which require additional carbon sources and plants which compete with food crops for arable land...
January 20, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29353257/ethical-dilemmas-of-recording-and-reviewing-neonatal-resuscitation
#7
REVIEW
Maria C den Boer, Mirjam Houtlosser, Henriëtte Anje van Zanten, Elizabeth E Foglia, Dirk P Engberts, Arjan B Te Pas
Neonatal resuscitation is provided to approximately 3% of neonates. Adequate ventilation is often the key to successful resuscitation, but this can be difficult to provide. There is increasing evidence that inappropriate respiratory support can have severe consequences. Several neonatal intensive care units have recorded and reviewed neonatal resuscitation procedures for quality assessment, education and research; however, ethical dilemmas sometimes make it difficult to implement this review process. We reviewed the literature on the development of recording and reviewing neonatal resuscitation and have summarised the ethical concerns involved...
January 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29353253/experiential-learning-to-increase-palliative-care-competence-among-the-indigenous-workforce-an-australian-experience
#8
Shaouli Shahid, Stuart Ekberg, Michele Holloway, Catherine Jacka, Patsy Yates, Gail Garvey, Sandra C Thompson
OBJECTIVES: Improving Indigenous people's access to palliative care requires a health workforce with appropriate knowledge and skills to respond to end-of-life (EOL) issues. The Indigenous component of the Program of Experience in the Palliative Approach (PEPA) includes opportunities for Indigenous health practitioners to develop skills in the palliative approach by undertaking a supervised clinical placement of up to 5 days within specialist palliative care services. This paper presents the evaluative findings of the components of an experiential learning programme and considers the broader implications for delivery of successful palliative care education programme for Indigenous people...
January 20, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29353251/cardiopulmonary-resuscitation-the-science-behind-the-hands
#9
REVIEW
Andrew W Harris, Peter J Kudenchuk
Sudden cardiac arrest is a leading cause of death worldwide. Despite significant advances in resuscitation science since the initial use of external chest compressions in humans nearly 60 years ago, there continues to be wide variability in rates of successful resuscitation across communities. The American Heart Association (AHA) and European Resuscitation Council emphasise the importance of high-quality chest compressions as the foundation of resuscitation care. We review the physiological basis for the association between chest compression quality and clinical outcomes and the scientific basis for the AHA's key metrics for high-quality cardiopulmonary resuscitation...
January 20, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29353205/wisp3-prevents-fibroblast-myofibroblast-transdifferentiation-in-nrk-49f-cells
#10
Yang Yi, Jun Ma, Lu Jianrao, Hangqing Wang, Yingdan Zhao
CCN family, a group of six extracellular matrix-associated proteins, plays an important role in fibrosis. WISP3 has addressed as a pro-fibrotic molecule in the development of human lung fibrosis. However, whether WISP3 involved in the activation and proliferation of renal fibroblast, and ultimately inhibited fibroblast-myofibroblast transdifferentiation remained unknown. Herein, we found that down-regulated WISP3 was involved in the fibrogenesis of rat renal NRK-49F cells induced by transforming growth (TGF-β1), which was further confirmed in a rat renal fibrosis induced by unilateral ureteral obstruction (UUO)...
January 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29353110/orchestration-of-chemomobilization-and-g-csf-administration-for-successful-hematopoietic-stem-cell-collection
#11
Katharina Kriegsmann, Anita Schmitt, Mark Kriegsmann, Thomas Bruckner, Adamma Anyanwu, Mathias Witzens-Harig, Carsten Müller-Tidow, Stefan Klein, Patrick Wuchter
Successful collection of peripheral blood stem cells (PBSCs) depends on the optimal orchestration of mobilization chemotherapy, granulocyte-colony-stimulating factor (G-CSF) application, and CD34+ cell number assessment in the peripheral blood (PB). However, determining the optimal timing in accordance to the applied chemomobilization regimen can be challenging. While most centers apply their own local timing schedules, a reliable timetable including the currently most often used mobilization regimens is lacking...
January 15, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29353089/influence-of-perceptions-and-stereotypes-of-the-nursing-role-on-career-choice-in-secondary-students-a-regional-perspective
#12
Anita Raymond, Ainsley James, Elisabeth Jacob, Judith Lyons
BACKGROUND: This study examined the influence that perceptions and stereotypes of the nursing role had on future career choice of rural secondary students. OBJECTIVE: The study was undertaken to identify a method of attracting final year secondary school students to an undergraduate nursing degree at a rural University. DESIGN: A mixed method study using a pre-post-interventional design. SETTING: The rural campus of an Australian university...
December 29, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29353050/helicobacter-pylori-infection-an-update-for-the-internist-in-the-age-of-increasing-global-antibiotic-resistance
#13
REVIEW
Osama Siddique, Anais Ovalle, Ayesha S Siddique, Steven F Moss
Helicobacter pylori (H. pylori) infects approximately half the world's population and is especially prevalent in the developing world. H. pylori is as an important cause of global ill health due to its known etiological role in peptic ulcer disease, dyspepsia, gastric cancer, lymphoma and, more recently recognised in iron deficiency anemia and idiopathic thrombocytopenic purpura. Increased antibiotic usage worldwide has led to antibiotic resistance among many bacteria, including H. pylori, resulting in falling success rates of first-line anti-H...
January 15, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29353023/diaphragm-excursion-time-index-a-new-parameter-using-ultrasonography-to-predict-extubation-outcome
#14
Atul Palkar, Mangala Narasimhan, Harly Greenberg, Karan Singh, Seth Koenig, Paul Mayo, Eric Gottesman
INTRODUCTION: The diaphragmatic response to increased mechanical load following withdrawal of mechanical ventilation (MV) is critical in determining the outcome of extubation. Using ultrasonography, we aimed to evaluate the performance of excursion-time (E-T) index- a product of diaphragm excursion and inspiratory time, to predict the outcome of extubation. METHODS: Right hemidiaphragm excursion, inspiratory time (Ti) and E-T index were measured using ultrasonography during MV: (1) On assist control mode (A/C) during consistent patient triggered ventilation (2) Following 30 minutes during a spontaneous breathing trial (SBT) (3) Between 4-24 hours following extubation...
January 15, 2018: Chest
https://www.readbyqxmd.com/read/29352971/magnetic-anchor-guided-endoscopic-submucosal-dissection-for-gastric-lesions-with-video
#15
Ippei Matsuzaki, Masashi Hattori, Ken Hirose, Masaya Esaki, Masakatsu Yoshikawa, Takio Yokoi, Makoto Kobayashi, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto
BACKGROUND AND AIM: The feasibility of magnetic anchor-guided endoscopic submucosal dissection (MAG-ESD) using a neodymium magnet for gastric lesions has not been clarified. The aim of study was to evaluate the feasibility of MAG-ESD using neodymium magnets while treating gastric lesions. METHODS: This prospective trial was conducted at the Yamashita Hospital. The MAG-ESD was performed for 50 gastric lesions using an insulated-tip knife. The magnetic anchor consisted of an internal neodymium magnet attached to a hemoclip with 3-0 silk...
January 15, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29352946/redox-enzyme-sensitive-chondroitin-sulfate-based-self-assembled-nanoparticles-loading-docetaxel-for-the-inhibition-of-metastasis-and-growth-of-melanoma
#16
Mengrui Liu, Hongliang Du, Abdur Rauf Khan, Jianbo Ji, Aihua Yu, Guangxi Zhai
In this report, redox/enzyme responsive chondroitin sulfate-ss-deoxycholic acid (CSCD) conjugates were synthesized using cystamine as the linkage which could self-assemble to form self-assembled nanoparticles (175.6 + 5.2 nm) in the aqueous environment. Docetaxel (DTX) was loaded in nanoparticles with desired loading efficiency for the inhibition of tumor growth and metastasis of melanoma. Interestingly, nanoparticles were demonstrated to respond to hyaluronidase-1 (Hyal-1) which could degrade chondroitin sulfate (CS) backbones...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352944/fabrication-of-cellulose-nanowhiskers-reinforced-chitosan-xylan-nanocomposite-films-with-antibacterial-and-antioxidant-activities
#17
Yuping Bao, Hao Zhang, Qian Luan, Mingming Zheng, Hu Tang, Fenghong Huang
Antibacterial and antioxidant chitosan-xylan/cellulose nanowhiskers (CNW) nanocomposite films were successfully prepared using CNW as nanofillers. The structure and morphology of the nanocomposite films were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and scanning electron microscopy (SEM). The optical transmittance, thermal stability, mechanical property, and swelling property of the nanocomposite films were also evaluated. These results revealed the microstructure of the films and confirmed the good miscibility between chitosan-xylan and CNW...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352925/influence-of-hydrothermal-treatment-on-the-structural-modification-of-spent-grain-specific-carbohydrates-and-the-formation-of-degradation-products-using-model-compounds
#18
J Steiner, K Franke, M Kießling, S Fischer, S Töpfl, V Heinz, T Becker
Brewer's spent grain (BSG) constitutes various valuable carbohydrates that may contribute to a healthy diet. These components may be obtained from BSG via hydrothermal treatment (HT), a procedure for dissolving water-inextricable carbohydrates. The objective of this study was to investigate HT as an environmentally friendly technology for extracting high-molecular-weight fiber with proven beneficial effects on human health. Cellulose, β-glucan, and arabinoxylan (AX) served as model substances and were subjected to auto-hydrolysis at different temperatures and reaction times...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352920/biomass-based-magnetic-fluorescent-nanoparticles-one-step-scalable-synthesis-application-as-drug-carriers-and-mechanism-study
#19
Lei Li, Feijun Wang, Ziqiang Shao
A biomass-based magnetic fluorescent nanoparticle (MFNPs) was successively in situ synthesized via a one-step high-gravity approach, which constructed by a magnetic core of Fe3O4 nanoparticles, the fluorescent marker of carbon dots (CDs), and shells of chitosan (CS). The obtained MFNPs had a 10 nm average diameter and narrow particle size distribution, low cytotoxicity, superior fluorescent emission and superparamagnetic properties. The encapsulating and release 5-fluorouracil experiments confirmed that the introduction of CS/CDs effectively improved the drug loading capacity...
March 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29352911/hpmcas-as-an-effective-precipitation-inhibitor-in-amorphous-solid-dispersions-of-the-poorly-soluble-drug-candesartan-cilexetil
#20
Juliana Munari Oliveira Pinto, Aline Franciane Leão, Manoela Klüppel Riekes, Maria Terezinha França, Hellen Karine Stulzer
Among the strategies to improve the biopharmaceutic properties of poorly soluble drugs, Supersaturating Drug Delivery Systems like polymer-based amorphous solid dispersions (SD) have been successfully applied. The screening of appropriate polymeric carriers to compose SD is a crucial point on their development. In this study, hydroxypropylmethylcellulose (HPMC), hydroxypropylmethylcellulose acetate succinate (HPMCAS) types L, M and H and polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (SOL) were evaluated by in vitro supersaturation studies regarding their anti-precipitant ability on the poorly soluble drug candesartan cilexetil (CC) under two different media, including biorelevant conditions...
March 15, 2018: Carbohydrate Polymers
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