James R Byrnes, Taek K Lee, Sherif Sharaby, Robert A Campbell, Dre'Von Dobson, Lori A Holle, Michelle Luo, Kadri Kangro, Jonathon Homeister, Maria M Aleman, James P Luyendyk, Bryce A Kerlin, Julie B Dumond, Alisa S Wolberg
Transglutaminase factor (F)XIII is essential for hemostasis, wound healing, and pregnancy maintenance. Plasma FXIII is composed of A and B subunit dimers synthesized in cells of hematopoietic origin and hepatocytes, respectively. The subunits associate tightly in circulation as FXIII-A2B2. FXIII-B2 stabilizes the (pro)active site-containing FXIII-A subunits. Interestingly, people with genetic FXIII-A deficiency have decreased FXIII-B2, and therapeutic infusion of recombinant FXIII-A2 (rFXIII-A2) increases FXIII-B2, suggesting FXIII-A regulates FXIII-B secretion, production, and/or clearance...
October 26, 2023: Blood