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https://www.readbyqxmd.com/read/29923258/accuracy-of-electronic-health-record-data-for-the-diagnosis-of-chronic-obstructive-pulmonary-disease-in-persons-living-with-hiv-and-uninfected-persons
#1
Kristina Crothers, Carla V Rodriguez, Robin M Nance, Kathleen Akgun, Shahida Shahrir, Joon Kim, Guy W Soo Hoo, Amir Sharafkhaneh, Heidi M Crane, Amy C Justice
PURPOSE: No prior studies have addressed the performance of electronic health record (EHR) data to diagnose chronic obstructive pulmonary disease (COPD) in people living with HIV (PLWH), in whom COPD could be more likely to be underdiagnosed or misdiagnosed, given the higher frequency of respiratory symptoms and smoking compared with HIV-uninfected (uninfected) persons. METHODS: We determined whether EHR data could improve accuracy of ICD-9 codes to define COPD when compared with spirometry in PLWH vs uninfected, and quantified level of discrimination using the area under the receiver-operating curve (AUC)...
June 20, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29921349/clinical-diagnoses-leading-to-suspension-in-army-aircrew-an-epidemiological-study
#2
Ian P Curry, Amanda M Kelley, Steven J Gaydos
INTRODUCTION: There have been few large-scale epidemiological examinations of military aircrew populations reported in recent literature. This study examined 10 yr of medical records contained in the U.S. Army Aeromedical Electronic Resource Office (AERO) in an effort to identify the most prevalent conditions affecting Army aviator career longevity. METHODS: This study was a retrospective epidemiological review; data were retrieved on 24,568 rated aircrew patients from the AERO database, of whom 5...
July 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29921044/current-status-of-endoscopic-submucosal-dissection-for-early-gastric-cancer-in-korea-role-and-benefits
#3
Sang Gyun Kim, Da Hyun Lyu, Chan Mi Park, Na Rae Lee, Jiyoung Kim, Youngju Cha, Hwoon-Yong Jung
Background/Aims: This study was aimed to investigate the current clinical status of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in Korea based on a National Health Insurance (NHI) database between 2011 and 2014. Methods: The claims data of ESD for EGC in Korean NHI were reviewed using material codes of Health Insurance Review and Assessment Service between November 2011 and December 2014. The current clinical status was analyzed in terms of treatment pattern, in-hospital length of stay (LOS), total medical costs, and en bloc resection rate according to the hospital type...
June 21, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29920438/life-s-simple-7-and-the-risk-of-atrial-fibrillation-the-multi-ethnic-study-of-atherosclerosis
#4
Oluseye Ogunmoroti, Erin D Michos, Konstantinos N Aronis, Joseph A Salami, Ron Blankstein, Salim S Virani, Erica S Spatz, Norrina B Allen, Jamal S Rana, Roger S Blumenthal, Emir Veledar, Moyses Szklo, Michael J Blaha, Khurram Nasir
BACKGROUND AND AIMS: We examined the association between the American Heart Association's Life's Simple 7 (LS7) metrics and the risk of atrial fibrillation (AF) in the Multi-Ethnic Study of Atherosclerosis (MESA), a prospective cohort study of adults free of cardiovascular disease (CVD) at baseline. METHODS: We analyzed data from 6506 participants. The LS7 metrics (smoking, physical activity, body mass index, diet, blood pressure, total cholesterol and blood glucose) were each categorized into ideal (assigned 2 points), intermediate (1 point) or poor (0 points)...
June 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29916548/methylation-profiles-of-mir34-gene-family-in-vietnamese-patients-suffering-from-breast-and-lung-cancers
#5
Vo Thi Thuong Lan, Ho Van Son, Vu Lan Trang, Nguyen Thu Trang, Nguyen Thi Phuong, Nguyen Linh Toan, Pham Anh Thuy Duong
The three genes encoding small non‑coding microRNA (miR)34a, MIR34b and MIR34c act as tumor‑suppressor genes. Their aberrant expressions regulated by DNA methylation have been frequently found in various types of cancer. In the present study, the DNA promoter methylation profiles of the MIR34 gene family were analyzed using the methylation specific polymerase chain reaction in order to clarify their association with breast and lung cancer, non‑cancerous or normal adjacent tissues. The methylation frequency of MIR34a was significantly higher in breast cancer (49...
June 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29915704/population-diversity-and-relatedness-in-sugarbirds-promeropidae-promerops-spp
#6
Evan S Haworth, Michael J Cunningham, Kathleen M Calf Tjorve
Sugarbirds are a family of two socially-monogamous passerine species endemic to southern Africa. Cape and Gurney's Sugarbird ( Promerops cafer and P. gurneyi ) differ in abundance, dispersion across their range and in the degree of sexual dimorphism in tail length, factors that affect breeding systems and potentially genetic diversity. According to recent data, P. gurneyi are in decline and revision of the species' IUCN conservation status to a threatened category may be warranted. It is therefore necessary to understand genetic diversity and risk of inbreeding in this species...
2018: PeerJ
https://www.readbyqxmd.com/read/29913100/hospitalization-trends-and-comorbidities-among-people-with-hiv-aids-compared-with-the-overall-hospitalized-population-illinois-2008-2014
#7
Livia Navon
OBJECTIVES: To understand trends in health care use among people living with HIV/AIDS (PLWHA), this study compared trends in hospitalization rates, comorbidities, and hospital death rates of hospitalized PLWHA with the overall hospitalized population in Illinois during 2008-2014. METHODS: This study identified principal hospitalizations (the principal discharge diagnosis coded with an HIV-related billing code) and secondary HIV hospitalizations (a non-principal discharge diagnosis coded with an HIV-related billing code) from 2008-2014 Illinois hospital discharge data...
January 1, 2018: Public Health Reports
https://www.readbyqxmd.com/read/29912735/effectiveness-of-a-model-bundle-payment-initiative-for-femur-fracture-patients
#8
Ariana Lott, Rebekah Belayneh, Jack Haglin, Sanjit Konda, Kenneth A Egol
OBJECTIVES: Analyze the effectiveness of a BPCI (Bundle Payments for Care Improvement) initiative for patients who would be included in a future potential Surgical Hip and Femur Fracture Treatment (SHFFT) bundle. DESIGN: Retrospective cohort SETTING:: Single Academic Institution PATIENTS/PARTICIPANTS:: Patients discharged with operative fixation of a hip or femur fracture (DRG codes 480-482) between 1/2015-10/2016 were included. A BPCI initiative based upon an established program for BPCI Total Joint Arthroplasty (TJA) was initiated for patients with hip and femur fractures in January 2016...
May 28, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29908781/-impact-of-cardiovascular-risk-factors-on-the-consumption-of-resources-in-primary-care-according-to-clinical-risk-groups
#9
Magdalena Millá Perseguer, Natividad Guadalajara Olmeda, David Vivas Consuelo
OBJECTIVE: To analyze the prevalence of Cardiovascular Risk Factors (CVRF) in the context of a Basic Health Area and the impact they generate on morbidity and consumption of healthcare resources in the stratified population according to the Clinical System Risk Groups (CRG) in Primary Care, with the purpose of identifying the population with multimorbidity to apply preventive measures, as well as the one that generates the highest care burden and social needs. DESIGN: Observational, cross-sectional and population-based study for a basic health area during 2013...
June 13, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29908705/high-levels-of-socioeconomic-deprivation-do-not-inhibit-patients-communication-of-concerns-in-head-and-neck-cancer-review-clinics
#10
S Allen, R Harris, S L Brown, G Humphris, Y Zhou, S N Rogers
To examine associations between socioeconomic status and the extent to which patients with cancer of the head and neck expressed concerns to surgeons during routine follow-up clinics, we analysed audio recordings of 110 consultations with one consultant. We used the Verona Coding Definitions of Emotional Sequences (VRCoDES) to measure communication between the doctor and the patient, and grouped the English indices of multiple deprivation (IMD) 2015 scores into deciles to compare the VRCoDES with socioeconomic status...
June 13, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29908216/complications-of-delivery-among-mothers-with-spina-bifida
#11
Courtney L Shepard, Phyllis L Yan, Stephanie J Kielb, Daniela A Wittmann, Elisabeth H Quint, Kate H Kraft, John M Hollingsworth
OBJECTIVE: To determine rates and types of peripartum morbidity among delivering women with spina bifida (SB) compared to those without SB. The rates of pregnancy and delivery among women with SB have been significantly increasing. Current knowledge of peripartum outcomes for these women is limited. METHODS: Using 2004-2013 National Inpatient Sample data, we identified all hospitalizations for delivery, distinguishing between women with and without SB. Using a code-based algorithm, we determined whether a complication occurred during the hospitalization...
June 13, 2018: Urology
https://www.readbyqxmd.com/read/29907560/validation-of-a-natural-language-processing-algorithm-for-detecting-infectious-disease-symptoms-in-primary-care-electronic-medical-records-in-singapore
#12
Antony Hardjojo, Arunan Gunachandran, Long Pang, Mohammed Ridzwan Bin Abdullah, Win Wah, Joash Wen Chen Chong, Ee Hui Goh, Sok Huang Teo, Gilbert Lim, Mong Li Lee, Wynne Hsu, Vernon Lee, Mark I-Cheng Chen, Franco Wong, Jonathan Siung King Phang
BACKGROUND: Free-text clinical records provide a source of information that complements traditional disease surveillance. To electronically harness these records, they need to be transformed into codified fields by natural language processing algorithms. OBJECTIVE: The aim of this study was to develop, train, and validate Clinical History Extractor for Syndromic Surveillance (CHESS), an natural language processing algorithm to extract clinical information from free-text primary care records...
June 11, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29903409/validation-of-data-from-electronic-data-warehouse-in-diabetic-ketoacidosis-caution-is-needed
#13
Jennifer VanderWeele, Teresa Pollack, Diana Johnson Oakes, Colleen Smyrniotis, Vidhya Illuri, Priyathama Vellanki, Kevin O'Leary, Jane Holl, Grazia Aleppo, Mark E Molitch, Amisha Wallia
AIMS: This study validated enterprise data warehouse (EDW) data for a cohort of hospitalized patients with a primary diagnosis of diabetic ketoacidosis (DKA). METHODS: 247 patients with 319 admissions for DKA (ICD-9 code 250.12, 250.13, or 250.xx with biochemical criteria for DKA) were admitted to Northwestern Memorial Hospital from 1/1/2010 to 9/1/2013. Validation was performed by electronic medical record (EMR) review of 10% of admissions (N = 32). Classification of diabetes type (Type 1 vs...
May 8, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29903379/body-mass-index-blood-pressure-and-cause-specific-mortality-in-india-a-prospective-cohort-study-of-500-810-adults
#14
Vendhan Gajalakshmi, Ben Lacey, Vendhan Kanimozhi, Paul Sherliker, Richard Peto, Sarah Lewington
BACKGROUND: The association between cause-specific mortality and body-mass index (BMI) has been studied mainly in high-income countries. We investigated the relations between BMI, systolic blood pressure, and mortality in India. METHODS: Men and women aged 35 years or older were recruited into a prospective study from the general population in Chennai, India between Jan 1, 1998, and Dec 31, 2001. Participants were interviewed (data collected included age, sex, education, socioeconomic status, medical history, tobacco smoking, and alcohol intake) and measured (height, weight, and blood pressure)...
July 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29901655/organizational-factors-contributing-to-incivility-at-an-academic-medical-center-and-systems-based-solutions-a-qualitative-study
#15
Reena Pattani, Shiphra Ginsburg, Alekhya Mascarenhas Johnson, Julia E Moore, Sabrina Jassemi, Sharon E Straus
PURPOSE: A rise in incivility has been documented in medicine, with implications for patient care, organizational effectiveness, and costs. This study explored organizational factors that may contribute to incivility at one academic medical center and potential systems-level solutions to combat it. METHOD: The authors completed semi-structured individual interviews with full-time faculty members of the department of medicine (DOM) at the University of Toronto Faculty of Medicine, Toronto, Canada, with clinical appointments at six affiliated hospitals, between June and September 2016...
June 12, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29899171/novel-approaches-for-the-treatment-of-familial-hypercholesterolemia-current-status-and-future-challenges
#16
Long Jiang, Lu-Ya Wang, Xiao-Shu Cheng
Familial hypercholesterolemia (FH) is an autosomal-dominant disorder that is characterized by high plasma low-density lipoprotein cholesterol (LDL-c) levels and an increased risk of cardiovascular disease. Despite the use of high-dose statins and the recent addition of proprotein convertase subtilisin/kexin type 9 inhibitors as a treatment option, many patients with homozygous FH fail to achieve optimal reductions of LDL-c levels. Gene therapy has become one of the most promising research directions for contemporary life sciences and is a potential treatment option for FH...
June 13, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29898949/processes-that-influence-the-evolution-of-family-health-teams
#17
Judith Belle Brown, Bridget L Ryan
OBJECTIVE: To identify the processes that influence the evolution of family health teams (FHTs). DESIGN: Qualitative study using grounded theory methodology. SETTING: Family health teams in Ontario. PARTICIPANTS: A total of 110 team members from 20 FHT sites in Ontario. METHODS: Individual semistructured interviews were conducted and data were analyzed using initial coding, focused coding, and a constant comparison analysis...
June 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29898651/mutational-signatures-in-cancer-musica-a-web-application-to-implement-mutational-signatures-analysis-in-cancer-samples
#18
Marcos Díaz-Gay, Maria Vila-Casadesús, Sebastià Franch-Expósito, Eva Hernández-Illán, Juan José Lozano, Sergi Castellví-Bel
BACKGROUND: Mutational signatures have been proved as a valuable pattern in somatic genomics, mainly regarding cancer, with a potential application as a biomarker in clinical practice. Up to now, several bioinformatic packages to address this topic have been developed in different languages/platforms. MutationalPatterns has arisen as the most efficient tool for the comparison with the signatures currently reported in the Catalogue of Somatic Mutations in Cancer (COSMIC) database. However, the analysis of mutational signatures is nowadays restricted to a small community of bioinformatic experts...
June 14, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29897738/coupling-gfp-expression-with-chemical-modification-to-probe-functionally-relevant-riboswitch-conformations-in-live-bacteria
#19
Debapratim Dutta, Ivan A Belashov, Joseph E Wedekind
Non-coding RNAs engage in numerous biological activities including gene regulation. To fully understand RNA function it is necessary to probe biologically relevant conformations in living cells. To address this challenge, we coupled RNA-mediated regulation of the GFPuv-reporter gene to icSHAPE (<u>i</u>n <u>c</u>ell <u><u>S</u></u>elective 2´-<u>H</u>ydroxyl <u><u>A</u></u>cylation analyzed by <u><u>P</u></u>rimer <u>E</u>xtension)...
June 13, 2018: Biochemistry
https://www.readbyqxmd.com/read/29895674/integrative-genome-wide-analysis-of-long-noncoding-rnas-in-diverse-immune-cell-types-of-melanoma-patients
#20
Lei Wang, Sara J Felts, Virginia P Van Keulen, Adam D Scheid, Matthew S Block, Svetomir N Markovic, Larry R Pease, Yuji Zhang
Genome-wide identification and characterization of long non-coding RNAs (lncRNAs) in individual immune cell lineages helps us better understand the driving mechanisms behind melanoma and advance personalized patient treatment. To elucidate the transcriptional landscape in diverse immune cell types of peripheral blood cells (PBC) in stage IV melanoma, we used whole transcriptome RNA sequencing to profile lncRNAs in CD4+, CD8+, and CD14+ PBC from 132 patient samples. Our integrative computational approach identified 27,625 expressed lncRNAs, 2,744 of which were novel...
June 12, 2018: Cancer Research
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