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https://www.readbyqxmd.com/read/29054836/formative-assessment-design-of-a-web-connected-sedentary-behavior-intervention-for-females
#1
Amber W Kinsey, Matthew Whipple, Lauren Reid, Olivia Affuso
BACKGROUND: Sedentary behavior (SB) is a significant risk factor for heart disease, diabetes, obesity, and early mortality, particularly among women, and the health consequences associated with SB are independent of physical activity status. Interventions utilizing wearable technologies can improve SB, but their effectiveness is influenced by individual preferences, device engagement strategies, and technological features, which may affect user compliance. Gathering a priori insight from target populations on their preferences for program tools and strategies may assist researchers in identifying effective methods to improve the efficacy of SB interventions...
October 20, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/29054261/development-and-validation-of-various-phenotyping-algorithms-for-diabetes-mellitus-using-data-from-electronic-health-records
#2
Santiago Esteban, Manuel Rodríguez Tablado, Francisco E Peper, Yamila S Mahumud, Ricardo I Ricci, Karin S Kopitowski, Sergio A Terrasa
BACKGROUND AND OBJECTIVE: Recent progression towards precision medicine has encouraged the use of electronic health records (EHRs) as a source for large amounts of data, which is required for studying the effect of treatments or risk factors in more specific subpopulations. Phenotyping algorithms allow to automatically classify patients according to their particular electronic phenotype thus facilitating the setup of retrospective cohorts. Our objective is to compare the performance of different classification strategies (only using standardized problems, rule-based algorithms, statistical learning algorithms (six learners) and stacked generalization (five versions)), for the categorization of patients according to their diabetic status (diabetics, not diabetics and inconclusive; Diabetes of any type) using information extracted from EHRs...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29053148/stress-response-of-a-marine-ammonia-oxidizing-archaeon-informs-physiological-status-of-environmental-populations
#3
Wei Qin, Shady A Amin, Rachel A Lundeen, Katherine R Heal, Willm Martens-Habbena, Serdar Turkarslan, Hidetoshi Urakawa, Kyle C Costa, Erik L Hendrickson, Tony Wang, David Ac Beck, Sonia M Tiquia-Arashiro, Fred Taub, Andrew D Holmes, Neeraja Vajrala, Paul M Berube, Todd M Lowe, James W Moffett, Allan H Devol, Nitin S Baliga, Daniel J Arp, Luis A Sayavedra-Soto, Murray Hackett, E Virginia Armbrust, Anitra E Ingalls, David A Stahl
High representation by ammonia-oxidizing archaea (AOA) in marine systems is consistent with their high affinity for ammonia, efficient carbon fixation, and copper (Cu)-centric respiratory system. However, little is known about their response to nutrient stress. We therefore used global transcriptional and proteomic analyses to characterize the response of a model AOA, Nitrosopumilus maritimus SCM1, to ammonia starvation, Cu limitation and Cu excess. Most predicted protein-coding genes were transcribed in exponentially growing cells, and of ~74% detected in the proteome, ~6% were modified by N-terminal acetylation...
October 20, 2017: ISME Journal
https://www.readbyqxmd.com/read/29053070/relationship-between-patient-safety-indicator-events-and-comprehensive-stroke-center-volume-status-in-the-treatment-of-unruptured-cerebral-aneurysms
#4
Chad W Washington, L Ian Taylor, Robert J Dambrino, Paul R Clark, Gregory J Zipfel
OBJECTIVE The Agency of Healthcare Research and Quality (AHRQ) has defined Patient Safety Indicators (PSIs) for assessments in quality of inpatient care. The hypothesis of this study is that, in the treatment of unruptured cerebral aneurysms (UCAs), PSI events are less likely to occur in hospitals meeting the volume thresholds defined by The Joint Commission for Comprehensive Stroke Center (CSC) certification. METHODS Using the 2002-2011 National (Nationwide) Inpatient Sample, patients treated electively for a nonruptured cerebral aneurysm were selected...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29051841/perceived-cost-advantages-and-disadvantages-of-purchasing-hiv-self-testing-kits-among-urban-tanzanian-men-an-inductive-content-analysis
#5
Larissa Jennings, Donaldson F Conserve, Jamison Merrill, Lusajo Kajula, Juliet Iwelunmor, Sebastian Linnemayr, Suzanne Maman
Impoverished men have lower rates of facility-based HIV counseling and testing and higher unknown HIV-positive status than women. Economic theory suggests that individuals will obtain an HIV test if anticipated benefits are greater than anticipated costs. Yet, few studies have investigated the range of financial preferences of HIV self-testing (HIVST) among poor men who decline testing or do not test regularly. Twenty-three interviews were conducted to qualitatively assess perceived costs saved and costs incurred from use of HIVST kits in infrequently- or never-tested Tanzanian men...
August 2017: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/29049425/comparison-of-internal-medicine-and-general-surgery-residents-assessments-of-risk-of-postsurgical-complications-in-surgically-complex-patients
#6
James M Healy, Kimberly A Davis, Kevin Y Pei
Importance: Anticipating postsurgical complications is a vital physician skill, particularly when counseling surgically complex patients on their risks of intervention. Although internists and surgeons both counsel patients on surgical risks, it is uncertain who is better equipped to accurately anticipate surgical complications. Objective: To examine how internal medicine and general surgery trainees compare in their assessment of risk of surgically complex patients...
October 11, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29049278/illicit-drug-use-illicit-drug-use-disorders-and-drug-overdose-deaths-in-metropolitan-and-nonmetropolitan-areas-united-states
#7
Karin A Mack, Christopher M Jones, Michael F Ballesteros
PROBLEM/CONDITION: Drug overdoses are a leading cause of injury death in the United States, resulting in approximately 52,000 deaths in 2015. Understanding differences in illicit drug use, illicit drug use disorders, and overall drug overdose deaths in metropolitan and nonmetropolitan areas is important for informing public health programs, interventions, and policies. REPORTING PERIOD: Illicit drug use and drug use disorders during 2003-2014, and drug overdose deaths during 1999-2015...
October 20, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29046511/human-resource-factors-associated-with-workplace-safety-and-health-education-of-small-manufacturing-businesses-in-korea
#8
Kyoung-Ok Park
OBJECTIVES: Human resources (HR) are essential indicators of safety and health (SH) status, and HR can be key sources of workplace safety management such as safety and health education at work (SHEW). This study analyzed significant HR factors associated with SHEW of small manufacturing businesses in Korea. METHODS: The secondary data of the 2012 Korea Occupational Safety and Health Trend Survey were used to achieve this research purpose. A total of 2,089 supervisors or managers employed in the small manufacturing businesses completed the interview survey...
October 18, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29046270/-mydepressionlookslike-examining-public-discourse-about-depression-on-twitter
#9
E Megan Lachmar, Andrea K Wittenborn, Katherine W Bogen, Heather L McCauley
BACKGROUND: Social media provides a context for billions of users to connect, express sentiments, and provide in-the-moment status updates. Because Twitter users tend to tweet emotional updates from daily life, the platform provides unique insights into experiences of mental health problems. Depression is not only one of the most prevalent health conditions but also carries a social stigma. Yet, opening up about one's depression and seeking social support may provide relief from symptoms...
October 18, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29045851/trends-in-pelvic-inflammatory-disease-emergency-department-visits-united-states-2006-2013
#10
Kristen Kreisel, Elaine W Flagg, Elizabeth Torrone
BACKGROUND: Pelvic inflammatory disease is a female genital tract disorder with severe reproductive sequelae. Due to difficulties in diagnosing pelvic inflammatory disease, it is not a reportable condition in many states. Females seeking care in emergency departments are a sentinel population for pelvic inflammatory disease surveillance. OBJECTIVE: To determine trends in diagnoses of acute pelvic inflammatory disease in a nationally representative sample of emergency departments...
October 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29045018/patient-disease-and-treatment-factors-associated-with-overall-survival-in-esthesioneuroblastoma
#11
Ryan M Carey, Joseph Godovchik, Alan D Workman, Edward C Kuan, Arjun K Parasher, Jinbo Chen, James N Palmer, Nithin D Adappa, Jason G Newman, Jason A Brant
BACKGROUND: Esthesioneuroblastomas (ENB) are uncommon and data regarding outcomes are often limited to single-institution series. The National Cancer Database (NCDB), which contains outcomes information from treatment centers across the United States, represents an opportunity to evaluate outcomes for rare diseases such as ENB across multiple institutions. METHODS: The NCDB was queried for location codes corresponding to the nasal cavity and paranasal sinuses and the histology code for ENB...
October 17, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29044586/males-with-prolactinoma-are-at-increased-risk-of-incident-cardiovascular-disease
#12
Konstantinos A Toulis, Tim Robbins, Narendra Reddy, Balachandran Kumarendran, Krishna Gokhale, Haren Wijesinghe, Kar Keung Cheng, Niki Karavitaki, John Wass, Krishnarajah Nirantharakumar
OBJECTIVE: To investigate whether the risk of incident cardiovascular disease (CVD) is increased in patients with prolactinoma. DESIGN: Population-based, retrospective, open-cohort study using The Health Improvement Network (THIN) database. PATIENTS: 2,233 patients with prolactinoma and 10,355 matched controls (1:5 ratio) from UK General Practices contributing to THIN were included. Sex, age, body mass index, and smoking status were used as matching parametres...
October 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29043284/exploring-the-position-of-community-based-nursing-in-iran-a-qualitative-study
#13
Heshmatolah Heydari, Zahra Rahnavard, Fatemeh Ghaffari
BACKGROUND: Community-based nursing focuses on providing health services to families and communities in the second and third levels of prevention and this can improve the individuals, families and communities' quality of life, and reduce the healthcare costs. The aim of this study was to explore the status of community-based nursing in Iran. METHODS: This qualitative study was conducted from March to November 2015, in Tehran, Iran, using the content analysis approach...
October 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29040522/behavioral-and-transcriptomic-analysis-of-trem2-null-mice-not-all-knockout-mice-are-created-equal
#14
Silvia S Kang, Aishe Kurti, Kelsey E Baker, Chia-Chen Liu, Marco Colonna, Jason D Ulrich, David M Holtzman, Guojun Bu, John D Fryer
It is clear that innate immune system status is altered in numerous neurodegenerative diseases. Human genetic studies have demonstrated that Triggering Receptor Expressed in Myeloid cells 2 (TREM2) coding variants have a strong association with Alzheimer's disease (AD) and other neurodegenerative diseases. To more thoroughly understand the impact of TREM2 in vivo, we studied the behavioral and cognitive functions of wild-type (WT) and Trem2-/- (KO) mice during basal conditions and brain function in the context of innate immune stimulation with peripherally administered lipopolysaccharide (LPS)...
October 11, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29038096/raising-awareness-about-cervical-cancer-using-twitter-content-analysis-of-the-2015-smearforsmear-campaign
#15
Philippe Lenoir, Bilel Moulahi, Jérôme Azé, Sandra Bringay, Gregoire Mercier, François Carbonnel
BACKGROUND: Cervical cancer is the second most common cancer among women under 45 years of age. To deal with the decrease of smear test coverage in the United Kingdom, a Twitter campaign called #SmearForSmear has been launched in 2015 for the European Cervical Cancer Prevention Week. Its aim was to encourage women to take a selfie showing their lipstick going over the edge and post it on Twitter with a raising awareness message promoting cervical cancer screening. The estimated audience was 500 million people...
October 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29036464/the-mimic-code-repository-enabling-reproducibility-in-critical-care-research
#16
Alistair E W Johnson, David J Stone, Leo A Celi, Tom J Pollard
Objective: Lack of reproducibility in medical studies is a barrier to the generation of a robust knowledge base to support clinical decision-making. In this paper we outline the Medical Information Mart for Intensive Care (MIMIC) Code Repository, a centralized code base for generating reproducible studies on an openly available critical care dataset. Materials and Methods: Code is provided to load the data into a relational structure, create extractions of the data, and reproduce entire analysis plans including research studies...
September 27, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29035189/cancer-screening-reminders-addressing-the-spectrum-of-patient-preferences
#17
Susan D Brandzel, Erin J Aiello Bowles, Arika Wieneke, Susan Carol Bradford, Kilian Kimbel, Hongyuan Gao, Diana Sm Buist
CONTEXT: Health care systems continue to seek evidence about how to optimize the efficiency and effectiveness of cancer screening reminders. Annual reminders to receive preventive services can be an efficient strategy. OBJECTIVE: To understand patient motivators and barriers to cancer screening and preferences about reminder strategies. DESIGN: We conducted 11 focus groups among adults recommended for cancer screening within Kaiser Permanente Washington...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29034844/microrna-cancer-and-diet-facts-and-new-exciting-perspectives
#18
Maria Letizia Motti, Stefania D'Angelo, Rosaria Meccariello
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs able to regulate gene expression at multiple levels. They are detected in tissues, blood, and other body fluids with high stability and have a recognized role in the maintaining of tissue homeostasis. Aberrant expression profile of miRNAs has been observed in several diseases, primarily cancer. As a consequence, the analysis of miRNA signature has recognized diagnostic and prognostic role in human diseases, and the development of miRNA-based therapies is currently under investigation...
October 13, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29032764/nanoemulsions-for-cosmetic-applications-what-innovation-status
#19
Myla L De Souza, Douglas Dourado Oliveira, Paulo Lima Ribeiro, Neila de Paula Pereira, Janice Izabel Druzian
BACKGROUND: Brazil is the fourth largest personal hygiene, perfumery and cosmetics (HPPC) consumer market in the world, leading industries to invest heavily in cosmetic research. Nanotechnology is studied and applied in several branches of health and, in the cosmetic area, focuses on the effectiveness of the products, safety of use and stability of the formulation. Thus, nanoemulsions appear as an attractive option for cosmetic manufacturers. OBJECTIVE: In this context, a technological investigation was carried out, through a patent search, with the objective of verifying the current panorama of the nanoemulsions for the development of cosmetic formulations...
October 10, 2017: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/29030707/characterization-and-genome-comparison-of-an-indian-isolate-of-bidensovirus-infecting-the-silkworm-bombyx-mori
#20
Tania Gupta, Katsuhiko Ito, Keiko Kadono-Okuda, Geetha N Murthy, E Vijaya Gowri, Kangayam M Ponnuvel
The bipartite genome of an Indian isolate of Bombyx mori bidensovirus (BmBDV), one of the causative agents of the fatal silkworm disease 'Flacherie', was cloned and completely sequenced. Nucleotide sequence analysis of this Indian isolate of BmBDV revealed two viral DNA segments, VD1 and VD2 as well as a DNA polymerase motif which supports its taxonomical status as the type species of a new family of Bidnaviridae. The Indian isolate of BmBDV was found to have a total of six putative ORFs four of which were located on the VD1 with the other two being on the VD2 DNA segment...
October 13, 2017: Archives of Virology
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