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https://www.readbyqxmd.com/read/28441533/a-global-view-of-rna-protein-interactions-identifies-post-transcriptional-regulators-of-root-hair-cell-fate
#1
Shawn W Foley, Sager J Gosai, Dongxue Wang, Nur Selamoglu, Amelia C Sollitti, Tino Köster, Alexander Steffen, Eric Lyons, Fevzi Daldal, Benjamin A Garcia, Dorothee Staiger, Roger B Deal, Brian D Gregory
The Arabidopsis thaliana root epidermis is comprised of two cell types, hair and nonhair cells, which differentiate from the same precursor. Although the transcriptional programs regulating these events are well studied, post-transcriptional factors functioning in this cell fate decision are mostly unknown. Here, we globally identify RNA-protein interactions and RNA secondary structure in hair and nonhair cell nuclei. This analysis reveals distinct structural and protein binding patterns across both transcriptomes, allowing identification of differential RNA binding protein (RBP) recognition sites...
April 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28440973/histochemical-and-immunohistochemical-study-of-%C3%AE-sma-collagen-and-pcna-in-epithelial-ovarian-neoplasm
#2
Nungki Anggorowati, Chatarina Ratna Kurniasari, Karina Damayanti, Titik Cahyanti, Irianiwati Widodo, Ahmad Ghozali, Muhammad Mansyur Romi, Dwi Cahyani Ratna Sari, Nur Arfian
Background: Alpha-smooth muscle actin (α-SMA) is an isoform of actin, positive in myofibroblasts and is an epithelial to mesenchymal transition (EMT) marker. EMT is a process by which tumor cells develop to be more hostile and able to metastasize. Progression of tumor cells is always followed by cell composition and extracellular matrix component alteration. Increased α-SMA expression and collagen alteration may predict the progressivity of ovarian neoplasms. Objective: The aim of this research was to analyse the characteristic of α-SMA and collagen in tumor cells and stroma of ovarian neoplasms...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28440201/investigation-of-the-ph-dependent-cytotoxicity-of-paclitaxel-conjugated-gold-nanoparticles
#3
Zahrah Alhalili, Nur Hikmatul Auliya, Barbara Sandersonb, J G Shapter
Breast cancer, apart from skin cancer, is the most common cancer among women accounting for nearly 1 in 3 cancers and the second leading cause of cancer-related death among women after lung cancer. Finding new approaches to treat such cancers is critically important. OBJECTIVE: This work investigated the ability of a simple system based on paclitaxel conjugated gold nanoparticles (AuNP) to induce efficient cytotoxicity against T47D breast cancerous cells at different pH values. METHOD: The synthesis and characterization of nanoparticles using two approaches is presented...
April 24, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28439298/multi-drug-resistant-pathogenic-bacteria-in-the-gut-of-young-children-in-bangladesh
#4
Shirajum Monira, Syeda Antara Shabnam, Sk Imran Ali, Abdus Sadique, Fatema-Tuz Johura, Kazi Zillur Rahman, Nur Haque Alam, Haruo Watanabe, Munirul Alam
BACKGROUND: The gut of human harbors diverse commensal microbiota performing an array of beneficial role for the hosts. In the present study, the major commensal gut bacteria isolated by culturing methods from 15 children of moderate income families, aged between 10 and 24 months, were studied for their response to different antibiotics, and the molecular basis of drug resistance. RESULTS: Of 122 bacterial colonies primarily selected from Luria-Bertani agar, bacterial genera confirmed by analytical profile index (API) 20E(®) system included Escherichia as the predominant (52%) organism, followed by Enterobacter (16%), Pseudomonas (12%), Klebsiella (6%), Pantoea (6%), Vibrio (3%), and Citrobacter (3%); while Aeromonas and Raoultella were identified as the infrequently occurring genera...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28438163/enhanced-status-of-inflammation-and-endothelial-activation-in-subjects-with-familial-hypercholesterolaemia-and-their-related-unaffected-family-members-a-case-control-study
#5
Thuhairah Rahman, Nur Suhana Hamzan, Atiqah Mokhsin, Radzi Rahmat, Zubin Othman Ibrahim, Rafezah Razali, Malathi Thevarajah, Hapizah Nawawi
BACKGROUND: Familial hypercholesterolaemia (FH) leads to premature coronary artery diseases (CAD) which pathophysiologically can be measured by inflammation, endothelial activation and oxidative stress status. However, the status of these biomarkers among related unaffected relatives of FH cases and whether FH is an independent predictor of these biomarkers have not been well established. Thus, this study aims to (1) compare the biomarkers of inflammation, endothelial activation and oxidative stress between patients with FH, their related unaffected relatives (RUC) and normolipaemic subjects (NC) (2)determine whether FH is an independent predictor of these biomarkers...
April 24, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28427478/morphological-and-molecular-characteristics-of-malayfilaria-sofiani-uni-mat-udin-takaoka-n-g-n-sp-nematoda-filarioidea-from-the-common-treeshrew-tupaia-glis-diard-duvaucel-mammalia-scandentia-in-peninsular-malaysia
#6
Shigehiko Uni, Ahmad Syihan Mat Udin, Takeshi Agatsuma, Weerachai Saijuntha, Kerstin Junker, Rosli Ramli, Hasmahzaiti Omar, Yvonne Ai-Lian Lim, Sinnadurai Sivanandam, Emilie Lefoulon, Coralie Martin, Daicus Martin Belabut, Saharul Kasim, Muhammad Rasul Abdullah Halim, Nur Afiqah Zainuri, Subha Bhassu, Masako Fukuda, Makoto Matsubayashi, Masashi Harada, Van Lun Low, Chee Dhang Chen, Narifumi Suganuma, Rosli Hashim, Hiroyuki Takaoka, Mohd Sofian Azirun
BACKGROUND: The filarial nematodes Wuchereria bancrofti (Cobbold, 1877), Brugia malayi (Brug, 1927) and B. timori Partono, Purnomo, Dennis, Atmosoedjono, Oemijati & Cross, 1977 cause lymphatic diseases in humans in the tropics, while B. pahangi (Buckley & Edeson, 1956) infects carnivores and causes zoonotic diseases in humans in Malaysia. Wuchereria bancrofti, W. kalimantani Palmieri, Pulnomo, Dennis & Marwoto, 1980 and six out of ten Brugia spp. have been described from Australia, Southeast Asia, Sri Lanka and India...
April 20, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28425275/associations-between-obesity-and-the-radiographic-phenotype-in-knee-osteoarthritis
#7
Mehmet Derya Demirağ, Seçil Özkan, Şeminur Haznedaroğlu, Evin Aras Kilinç, Fatma Nur Baran Aksakal, Sefer Aycan, Berna Göker
BACKGROUND/AIM: Investigation of the association between obesity and the distinction of radiographic patterns in knee osteoarthritis. MATERIALS AND METHODS: Seven hundred and thirty-four women underwent weight-bearing antero-posterior knee radiography. Osteophytes and joint space narrowing (JSN) were graded according to the OARSI atlas. Each subject was assigned to one of the following groups with respect to the maximum score: osteophyte-dominant, indeterminate, JSN-dominant, and radiographically normal...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28422886/comparison-of-t2-and-t3-sympathectomy-for-compensatory-sweating-on-palmar-hyperhidrosis
#8
Atila Turkyilmaz, Sami Karapolat, Kubra Nur Seyis, Celal Tekinbas
BACKGROUND: An otherwise successfully performed endoscopic thoracic sympathectomy (ETS) to treat palmar hyperhidrosis (PH) often has a serious side effect: compensatory sweating (CS). This side effect occurs in other parts of the body to a disturbing extent. The objective of this study is to determine whether there is a relationship between the level of ETS performed on patients with PH, and the occurrence and severity of postoperational CS. METHODS: Between January 2014 and January 2015, ETS procedures were performed on 25 randomly selected consecutive subjects (group A) at T2 level, and on another 25 subjects (group B) at T3 level, who all felt severely handicapped due to PH...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28421151/extramedullary-relapse-in-a-cml-patient-after-allogeneic-stem-cell-transplantation
#9
Asu Fergun Yilmaz, Nur Soyer, Nazan Ozsan, Seckin Cagirgan, Ajda Gunes, Melda Comert, Fahri Sahin, Guray Saydam, Nur Selvi Gunel, Filiz Vural
Myeloid or granulocytic sarcoma (GS) is a tumoral lesion consisting of immature granulocytic cells. It is a rare entity during the course of CML patients especially after allogeneic stem cell transplantation (SCT). Relapse without bone marrow involvement is much rarer. We report a case of CML patient who relapsed with isolated granulocytic sarcoma after allogeneic SCT during cytogenetic and molecular remission. 28-year-old male was diagnosed as CML and allogeneic SCT was performed because of refractory disease to tyrosine kinase inhibitors...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28420929/perception-of-pathology-as-a-future-career-choice-among-medical-students-from-karachi-pakistan-experience-from-a-private-medical-school
#10
Najia Karim Ghanchi, Raabia Nizamuddin Nizamuddin, Amna Qasim, Zahra Nur Khaled, Ahmed Buksh Raheem, Natasha Ali, Naila Kayani, Mohammad Asim Beg
To determine the perception of pathology as a future career choice among medical students of a private medical school from Karachi, Pakistan. A descriptive cross-sectional study was conducted at the Aga Khan University, Karachi, Pakistan. A total of 201 students participated in this study. All Students were approached randomly to participate. A total of 201 students participant survey forms were evaluated in this study. The overall satisfaction level with pathology was observed in 61.8% of the students. Majority of the students understood subspecialties which were a part of clinical medicine...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28420149/advanced-stage-at-presentation-remains-a-major-factor-contributing-to-breast-cancer-survival-disparity-between-public-and-private-hospitals-in-a-middle-income-country
#11
Yek-Ching Kong, Nirmala Bhoo-Pathy, Shridevi Subramaniam, Nanthini Bhoo-Pathy, Nur Aishah Taib, Suniza Jamaris, Kiran Kaur, Mee-Hoong See, Gwo-Fuang Ho, Cheng-Har Yip
Background: Survival disparities in cancer are known to occur between public and private hospitals. We compared breast cancer presentation, treatment and survival between a public academic hospital and a private hospital in a middle-income country. Methods: The demographics, clinical characteristics, treatment and overall survival (OS) of 2767 patients with invasive breast carcinoma diagnosed between 2001 and 2011 in the public hospital were compared with 1199 patients from the private hospital. Results: Compared to patients in the private hospital, patients from the public hospital were older at presentation, and had more advanced cancer stages...
April 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28419685/scaffolds-for-epithelial-tissue-engineering-customized-in-elastomeric-molds
#12
Mohamed-Nur Abdallah, Sara Abdollahi, Marco Laurenti, Dongdong Fang, Simon D Tran, Marta Cerruti, Faleh Tamimi
Restoration of soft tissue defects remains a challenge for surgical reconstruction. In this study, we introduce a new approach to fabricate poly(d,l-lactic acid) (PDLLA) scaffolds with anatomical shapes customized to regenerate three-dimensional soft tissue defects. Highly concentrated polymer/salt mixtures were molded in flexible polyether molds. Microcomputed tomography showed that with this approach it was possible to produce scaffolds with clinically acceptable volume ratio maintenance (>90%). Moreover, this technique allowed us to customize the average pore size and pore interconnectivity of the scaffolds by using variations of salt particle size...
April 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28418340/risk-adapted-management-of-febrile-neutrepenia-and-early-cessation-of-empirical-antibiotherapy-in-hematopoietic-stem-cell-transplantation-setting
#13
Ali Hakan Kaya, Emre Tekgündüz, Fazilet Duygu, Dicle Koca, Filiz Bekdemir, Hikmetullah Batgi, Bahar Ulu Uncu, Tuğçe Nur Yiğenoğlu, Mehmet Sinan Dal, Merih Çakar Kızıl, Fevzi Altuntaş
BACKGROUND: Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. AIMS: To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol in febrile neutropenia patients who have undergone haematopoietic stem cell transplantation at our clinic. STUDY DESIGN: Descriptive study...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28417423/evaluation-of-the-expression-of-amyloid-precursor-protein-and-the-ratio-of-secreted-amyloid-beta-42-to-amyloid-beta-40-in-sh-sy5y-cells-stably-transfected-with-wild-type-single-mutant-and-double-mutant-forms-of-the-app-gene-for-the-study-of-alzheimer-s-disease
#14
Aslina Pahrudin Arrozi, Siti Nur Syazwani Shukri, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof, Mohd Hanafi Ahmad Damanhuri, Suzana Makpol
Neuroblastoma cell lines such as SH-SY5Y are the most frequently utilized models in neurodegenerative research, and their use has advanced the understanding of the pathology of neurodegeneration over the past few decades. In Alzheimer's disease (AD), several pathogenic mutations have been described, all of which cause elevated levels of pathological hallmarks such as amyloid-beta (Aβ). Although the genetics of Alzheimer's disease is well known, familial AD only accounts for a small number of cases in the population, with the rest being sporadic AD, which contains no known mutations...
April 17, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28417352/follicular-adamts-1-and-aggrecan-levels-in-polycystic-ovary-syndrome
#15
Esra Nur Tola, Dilek Ulusoy Karatopuk, Nadiye Koroglu, Merve Ergin, Hilmi Baha Oral
PURPOSE: Polycystic ovary syndrome (PCOS) is the most common cause of ovulatory dysfunction and female infertility. The etiopathogenetic mechanisms of PCOS have been studied for many years, although exact causes remain unclear. It has been demonstrated that proteoglycan degradation by a disintegrin-like metalloproteinase with thrombospondin type motifs-1 (ADAMTS-1) is essential for ovulation and fertilization. The objective of our study is to analyze the levels of ADAMTS-1 and aggrecan in the follicular fluid (FF) of PCOS patients compared with normal ovulatory women and to determine whether these markers could be a predictor of in vitro fertilization (IVF) success in PCOS patients...
April 17, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28416785/a-novel-mutation-in-the-glycine-decarboxylase-gene-in-patient-with-non-ketotic-hyperglycinemia
#16
Engin Kose, Uluc Yis, Semra Hiz, Nur Arslan
Non-ketotic hyperglycinemia (NKH) is a rare inborn error of metabolism and is caused by a glycine cleavage system deficiency. Eighty-five percent of patients present with the neonatal type of NKH, the infants initially develop lethargy, seizures, and episodes of apnea, and most often death. Between 60-90% of cases are caused by mutations in the glycine decarboxylase (GLDC). We believed that more mutation reports especially for rare disease as NKH help to evaluate the genotype-phenotype relationship in patients with GLDC...
April 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/28415891/influence-of-two-electrode-montages-on-the-level-specific-ls-ce-chirp-auditory-brainstem-response-abr-at-multiple-intensity-levels
#17
Ahmad Aidil Arafat Dzulkarnain, Siti Hajra Mu'minah Noor Ibrahim, Nur Farah Aida Anuar, Siti Aisyah Abdullah, Tengku Zulaila Hasma Tengku Zam Zam, Sarah Rahmat, Muhammad Amar Mohd Ruzai
OBJECTIVE: To investigate the influence of two different electrode montages (ipsilateral: reference to mastoid and vertical: reference to nape of neck) to the ABR results recorded using a level-specific (LS)-CE-Chirp® in normally hearing subjects at multiple intensities levels. DESIGN: Quasi-experimental and repeated measure study designs were applied in this study. Two different stopping criteria were used, (1) a fixed-signal averaging 4000 sweeps and, (2) a minimum quality indicator of Fmp = 3...
April 18, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28414797/big1-is-required-for-the-survival-of-deep-layer-neurons-neuronal-polarity-and-the-formation-of-axonal-tracts-between-the-thalamus-and-neocortex-in-developing-brain
#18
Jia-Jie Teoh, Tomohiko Iwano, Masataka Kunii, Nur Atik, Erda Avriyanti, Shin-Ichiro Yoshimura, Kenta Moriwaki, Akihiro Harada
BIG1, an activator protein of the small GTPase, Arf, and encoded by the Arfgef1 gene, is one of candidate genes for epileptic encephalopathy. To know the involvement of BIG1 in epileptic encephalopathy, we analyzed BIG1-deficient mice and found that BIG1 regulates neurite outgrowth and brain development in vitro and in vivo. The loss of BIG1 decreased the size of the neocortex and hippocampus. In BIG1-deficient mice, the neuronal progenitor cells (NPCs) and the interneurons were unaffected. However, Tbr1+ and Ctip2+ deep layer (DL) neurons showed spatial-temporal dependent apoptosis...
2017: PloS One
https://www.readbyqxmd.com/read/28412052/-the-relationship-between-preoperative-anxiety-levels-and-vasovagal-incidents-during-the-administration-of-spinal-anesthesia
#19
Mürsel Ekinci, Birzat Emre Gölboyu, Onur Dülgeroğlu, Murat Aksun, Pınar Karaca Baysal, Erkan Cem Çelik, Ayşe Nur Yeksan
BACKGROUND: It was aimed to investigate the relationship between preoperative anxiety and vasovagal symptoms observed during the administration of spinal anesthesia in patients undergoing surgery in the perianal and inguinal regions. METHODS: The study included patients with planned surgery for inguinal hernia repair, anal fissure, hemorrhoid and pilonidal sinus excision. The study included a total of 210 patients of ASA I-II, aged 18-65 years. Patients were evaluated in respect of demographic characteristics, smoking and alcohol consumption, ASA grade and educational level...
April 12, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28410821/-analgesia-nociception-index-for-perioperative-analgesia-monitoring-in-spinal-surgery
#20
Guldem Turan, Arzu Yıldırım Ar, Yıldız Yigit Kuplay, Oznur Demiroluk, Mustafa Gazi, Nur Akgun, Erhan Celikoglu
BACKGROUND AND OBJECTIVES: The Analgesia Nociception Index is an index used to measure the levels of pain, sympathetic system activity and heart rate variability during general anesthesia. In our study, Analgesia Nociception Index monitoring in two groups who had undergone spinal stabilization surgery and were administered propofol-remifentanil (Total Intravenous Anesthesia) and sevoflurane-remifentanyl anesthesia was compared regarding its significance for prediction of postoperative early pain...
April 11, 2017: Revista Brasileira de Anestesiologia
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