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miR-34a

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https://www.readbyqxmd.com/read/29790665/long-noncoding-rna-ufc1-is-activated-by-e2f1-and-exerts-oncogenic-properties-by-functioning-as-a-cerna-of-foxp3
#1
Jie Xi, Jing Feng, Saitian Zeng, Ping Huang
Cervical cancer is one of the most common gynecologic cancers around the world. Long noncoding RNAs (lncRNAs) are considered to be important regulators of some biological processes. Recently, it has been reported that linc-UFC1 is a putative oncogene in some cancers. However, the functional roles of linc-UFC1 have not been investigated in cervical cancer. Here, it was demonstrated that linc-UFC1 expression was significantly increased in cervical cancer tissues, and its overexpression was associated with the poor survival of patients with cervical cancer...
May 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29780367/expression-of-mir-34a-in-t-cells-infected-by-human-t-lymphotropic-virus-1
#2
Varun K Sharma, Vittoria Raimondi, Katia Ruggero, Cynthia A Pise-Masison, Ilaria Cavallari, Micol Silic-Benussi, Vincenzo Ciminale, Donna M D'Agostino
Human T-lymphotropic virus 1 (HTLV-1) immortalizes T-cells and is the causative agent of adult T-cell leukemia/lymphoma (ATLL). HTLV-1 replication and transformation are governed by multiple interactions between viral regulatory proteins and host cell factors that remain to be fully elucidated. The present study investigated the impact of HTLV-1 infection on the expression of miR-34a, a microRNA whose expression is downregulated in many types of cancer. Results of RT-PCR assays showed that five out of six HTLV-1-positive cell lines expressed higher levels of miR-34a compared to normal PBMC or purified CD4+ T-cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29775159/bioinformatics-functional-analysis-of-let-7a-mir-34a-and-mir-199a-b-reveals-novel-insights-into-immune-system-pathways-and-cancer-hallmarks-for-hepatocellular-carcinoma
#3
Bangly Soliman, Ahmed Salem, Mohamed Ghazy, Nourhan Abu-Shahba, Mahmoud El Hefnawi
Let-7a, miR-34a, and miR-199 a/b have gained a great attention as master regulators for cellular processes. In particular, these three micro-RNAs act as potential onco-suppressors for hepatocellular carcinoma. Bioinformatics can reveal the functionality of these micro-RNAs through target prediction and functional annotation analysis. In the current study, in silico analysis using innovative servers (miRror Suite, DAVID, miRGator V3.0, GeneTrail) has demonstrated the combinatorial and the individual target genes of these micro-RNAs and further explored their roles in hepatocellular carcinoma progression...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29773953/mir-34a-mediated-regulation-of-xist-in-female-cells-under-inflammation
#4
Botros B Shenoda, Yuzhen Tian, Guillermo M Alexander, Enrique Aradillas-Lopez, Robert J Schwartzman, Seena K Ajit
Background: Evidence is overwhelming for sex differences in pain, with women representing the majority of the chronic pain patient population. There is a need to explore novel avenues to elucidate this sex bias in the development of chronic inflammatory pain conditions. Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder, and the incidence of CRPS is greater in women than in men by ~4:1. Since neurogenic inflammation is a key feature of CRPS, dysregulation of inflammatory responses can be a factor in predisposing women to chronic pain...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29771420/imp3-promotes-tnbc-stem-cell-property-through-mirna-34a-regulation
#5
Q-D Huang, S-R Zheng, Y-J Cai, D-L Chen, Y-Y Shen, C-Q Lin, X-Q Hu, X-H Wang, H Shi, G-L Guo
OBJECTIVE: To explore the expression and function of insulin-like growth factor II (IGFII) mRNA binding protein (IMP3) in the Triple Negative Breast Cancer (TNBC). MATERIALS AND METHODS: According to previously reported gene expression array, we found that IMP3 had significantly higher expression in the CD44+CD24-ESA+ cell cluster, tumor initiating cell or cancer stem cell (CSCs), compared to other tumor cells. Based on the GEO database (GEO accession No. GSE6883), we detected the mRNA levels of IMP 1,2 and 3 by quantitative polymerase chain reaction (q-PCR) in CD44+CD24-ESA+ cell cluster and other breast tumor cell clusters...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29760516/microrna-and-transcriptome-analysis-in-periocular-sebaceous-gland-carcinoma
#6
John C Bladen, Jun Wang, Ajanthah Sangaralingam, Mariya Moosajee, Caroline Fitchett, Claude Chelala, Michele Beaconsfield, Edel A O'Toole, Michael P Philpott, Daniel G Ezra
Sebaceous gland carcinoma (SGC) is a rare, but life-threatening condition with a predilection for the periocular region. Eyelid SGC can be broadly categorised into two subtypes, namely either nodular or pagetoid with the latter being more aggressive and requiring radical excision to save life. We have identified key altered microRNAs (miRNA) involved in SGC shared by both subtypes, hsa-miR-34a-5p and hsa-miR-16-5p. However, their gene targets BCL2 and MYC were differentially expressed with both overexpressed in pagetoid but unchanged in nodular suggesting different modes of action of these two miRNAs on BCL/MYC expression...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29750293/downregulation-of-microrna%C3%A2-34a-inhibits-oxidized-low%C3%A2-density-lipoprotein%C3%A2-induced-apoptosis-and-oxidative-stress-in-human-umbilical-vein-endothelial-cells
#7
Xiaoming Zhong, Peng Li, Juan Li, Ruili He, Guanchang Cheng, Yanming Li
Oxidized low‑density lipoprotein (ox‑LDL) promotes endothelial cell dysfunction, which is a primary risk factor for the development of atherosclerosis. A previous study reported that microRNA (miRNA/miR)‑34a is upregulated in atherosclerotic samples. However, its function and underlying mechanisms remain to be fully elucidated. In the present study, miRNA microarray analysis was performed to investigate the miRNA expression profile in atherosclerotic plaque tissues and examine the role of miR‑34a in ox‑LDL‑induced apoptosis of human umbilical vein endothelial cells (HUVECs)...
May 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29749304/the-deterministic-role-of-5-mers-in-microrna-gene-targeting
#8
Martin Hart, Fabian Kern, Christina Backes, Stefanie Rheinheimer, Tobias Fehlmann, Andreas Keller, Eckart Meese
MiRNAs play a central role in physiological and pathological processes. Both for the biological understanding and for their clinical application, it is essential to understand the interaction of miRNAs and their targets. Target identification largely hinges on in-silico prediction, which requires a complete consideration of miRNA binding sites within the UTRs of target genes. Here, we show that 5-mer sites might also play an essential role for human miRNA-target binding. We implemented and employed an algorithm to all pairs of 2,588 human miRNAs annotated in miRBase and the 3' UTRs of 16725 genes (>43 million combinations)...
May 11, 2018: RNA Biology
https://www.readbyqxmd.com/read/29748184/dual-suppressive-effect-of-microrna-34a-on-the-foxm1-eef2-kinase-axis-regulates-triple-negative-breast-cancer-growth-and-invasion
#9
Recep Bayraktar, Cristina Ivan, Emine Bayraktar, Pinar Kanlikilicer, Nashwa Kabil, Nermin Kahraman, Hamada Ahmed Mokhlis, Didem Karakas, Cristian Rodriguez-Aguayo, Ahmet Arslan, Jianting Sheng, Stephen Tc Wong, Gabriel Lopez-Berestein, George A Calin, Bulent Ozpolat
Purpose - Recent studies indicated that dysregulation of non-coding RNAs (ncRNAs) such as microRNAs (miRNAs) is involved in pathogenesis of various human cancers. However, the molecular mechanisms underlying miR-34a are not fully understood in triple-negative breast cancer (TNBC). Experimental Design- We performed  in vitro  functional assays on TNBC cell lines to investigate the role of miR-34a in FOXM1/eEF2K signaling axis. TNBC tumor xenograft models were used for in vivo therapeutic delivery of miR-34a...
May 10, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29747513/cholesterol-and-morpholine-grafted-cationic-amphiphilic-copolymers-for-mirna-34a-delivery
#10
Saurabh Sharma, Samrat Mazumdar, Kishan S Italiya, Tushar Date, Ram I Mahato, Anupama Mittal, Deepak Chitkara
miR-34a is a master tumor suppressor playing a key role in the several signalling mechanisms involved in cancer. However its delivery to the cancer cells is the bottleneck in its clinical translation. Herein we report cationic amphiphilic copolymers grafted with cholesterol (chol), N,N-dimethyldipropylenetriamine (cation chain) and 4-(2-aminoethyl)morpholine (morph) for miR-34a delivery. The copolymer interacts with miR-34a at low N/P ratios (~2/1) to form nanoplexes of size ~108 nm and a zeta potential ~ +39 mV...
May 10, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29747371/-role-of-microrna-and-lncrna-in-lens-development-and-cataract-formation
#11
J L Zheng, J Sun, H Zhang, Y Zhang
Both microRNA (miRNA) and long noncoding RNA (lncRNA) fall within the category of noncoding RNA. MiRNA is a 20-24 nt long, highly conserved, single-stranded noncoding RNA. MiRNA can specifically bind to the 3' untranslated region of target mRNA, induce the transcript degradation or translation inhibition, and eventually impact the biological functions of the cell, such as proliferation, differentiation, and apoptosis. Whereas lncRNA is an over 200 bp long, single-stranded, noncoding RNA, which can regulate the important biological processes, such as cell division, growth, differentiation and apoptosis...
May 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29743907/circulating-mirna-levels-differ-with-respect-to-carotid-plaque-characteristics-and-symptom-occurrence-in-patients-with-carotid-artery-stenosis-and-provide-information-on-future-cardiovascular-events
#12
Rafal Badacz, Tadeusz Przewłocki, Jacek Gacoń, Ewa Stępień, Francisco J Enguita, Izabela Karch, Krzysztof Żmudka, Anna Kabłak-Ziembicka
Introduction: Circulating microRNAs (miRNAs) levels are potentially important biomarkers and therapeutic targets of cerebral ischemic event (CIE) in patients with internal carotid artery stenosis (ICAS). Aim: This prospective study investigated associations between circulating miRNAs and symptomatic and asymptomatic ICAS, carotid plaque morphology and future cardiovascular events. Material and methods: Circulating miRNAs (miR-1-3p, miR-16-5p, miR-34a-5p, miR-124-3p, miR-133a-3p, miR-133b, miR-134-5p, miR-208b-3p, miR-375 and miR-499-5p) were analyzed in 92 consecutive patients with significant ICAS referred for revascularization...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29743447/hydrogen-sulfide-ameliorates-rat-myocardial-fibrosis-induced-by-thyroxine-through-pi3k-akt-signaling-pathway
#13
Maojun Liu, Zining Li, Biao Liang, Ling Li, Shengquan Liu, Wenting Tan, Junrong Long, Fen Tang, Chun Chu, Jun Yang
This study aims to investigate the role and regulatory mechanism of the Hydrogen sulfide (H2 S) in amelioration of rat myocardial fibrosis induced by thyroxine through interfering the autophagy via regulating the activity of PI3K/AKT1 signaling pathway and the expression of relative miRNA. 40 adult male SD rats were randomly divided into 4 groups (n = 10): the control group, the thyroxine model group (TH group), the model group with H2 S intervention (TH + H2 S group) and the normal group with H2 S intervention (H2 S group)...
May 9, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29721409/in-situ-monitoring-of-microrna-replacement-efficacy-and-accurate-imaging-guided-cancer-therapy-through-light-up-inter-polyelectrolyte-nanocomplexes
#14
Xiongwei Deng, Zhaoxia Yin, Jianqing Lu, Xianlei Li, Leihou Shao, Caiyan Zhao, Yishu Yang, Qin Hu, Yan Wu, Wang Sheng
Replacement of downregulated tumor-suppressive microRNA (Ts-miRNA) is recognized as an alternative approach for tumor gene therapy. However, in situ monitoring of miRNA replacement efficacy in a real-time manner via noninvasive imaging is continually challenging. Here, glutathione (GSH)-activated light-up peptide-polysaccharide-inter-polyelectrolyte nanocomplexes are established through self-assembly of carboxymethyl dextran with disulfide-bridged ("S-S") oligoarginine peptide (S-Arg4 ), in which microRNA-34a (miR-34a) and indocyanine green (ICG) are simultaneously embedded and the nanocomplexes are subsequently stabilized by intermolecular cross-linking...
April 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29721189/assessment-of-micro-rnas-expression-in-leukemic-cells-as-prognostic-markers-in-chronic-lymphocytic-leukemia-micro-rnas-can-predict-survival-in-a-course-of-the-disease
#15
Agnieszka Szymczyk, Sylwia Chocholska, Arkadiusz Macheta, Dariusz Szczepanek, Marek Hus, Monika Podhorecka
Numerous genetic alterations predicting prognosis and clinical outcome are revealed recently in chronic lymphocytic leukemia (CLL). Among them the deregulated expression of micro RNAs that can induce tumor growth, or act as tumor suppressors seem to be of great importance. This study aimed to analyze the possible role of chosen micro RNAs as markers of prognosis in patients with CLL. We assessed the expression of miR-21, miR-34a, miR-181a, miR-199a/b and miR-221 in previously separated leukemic cells with the use of qRQ-PCR technique at the moment of diagnosis...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29704100/downregulation-of-mir-34a-promotes-endothelial-cell-growth-and-suppresses-apoptosis-in-atherosclerosis-by-regulating-bcl-2
#16
Gang Su, Guangli Sun, Hai Liu, Liliang Shu, Zhenxing Liang
Several miRNAs have been demonstrated to be involved in endothelial dysfunction during atherosclerosis (AS). However, the detailed roles and underlying mechanisms of miR-34a in AS-associated endothelial cell apoptosis are far from being addressed. Apolipoprotein E-deficient (ApoE-/- ) mice fed with high-fat diet (HFD) were used as in vivo model of AS. Oxidized low-density lipoprotein (ox-LDL)-treated human aortic endothelial cells (HAECs) were applied as in vitro model of AS. The effects of miR-34a on atherosclerotic lesions were evaluated by hematoxylin-eosin (HE) and Oil Red O staining...
April 27, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29700282/lincrna-1700020i14rik-alleviates-cell-proliferation-and-fibrosis-in-diabetic-nephropathy-via-mir-34a-5p-sirt1-hif-1%C3%AE-signaling
#17
Ailing Li, Rui Peng, Yan Sun, Handeng Liu, Huimin Peng, Zheng Zhang
Long intergenic noncoding RNAs (lincRNAs) have been gradually identified to be functional in a variety of different mechanisms associating with development and epigenetic regulation of cellular homeostasis. However, the study of lincRNAs in diabetic nephropathy (DN) is still in its infancy. Here, we have found dysexpressed long noncoding RNAs (lncRNAs) in renal tissues of db/db DN mice compared with db/m mice by RNA sequencing. In this study, 5 lincRNAs were confirmed to express in a consistent trend among these DN-related lncRNAs both in vivo and in vitro...
April 27, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29689563/microrna-34a-inhibition-of-the-tlr-signaling-pathway-via-cxcl10-suppresses-breast-cancer-cell-invasion-and-migration
#18
Min Xu, Dong Li, Chen Yang, Jian-Song Ji
BACKGROUND/AIMS: Breast cancer (BC) starts as a local disease, but it can metastasize to the lymph nodes and distant organs. However, the metastatic process is still poorly understood. The mRNA microarray datasets GSE26910 and GSE33447 show that CXCL10 is up-regulated in BC, and the microRNA microarray dataset GSE38167 and a network meta-analysis of microRNA expression profile studies in human BC suggest that microRNA-34a (miR-34a) is down-regulated in BC. CXCL10 was predicted as a target of miR-34a by microRNA...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29681936/metformin-regulating-mir-34a-pathway-to-inhibit-egr1-in-rat-mesangial-cells-cultured-with-high-glucose
#19
Can Wu, Ningning Qin, Huiwen Ren, Min Yang, Shuang Liu, Qiuyue Wang
Background: Activating AMPK α negatively regulates Egr1 to inhibit inflammatory cytokines in high glucose. miR-34a inhibition increases phosphorylated AMPK α through mediating SIRT1 to suppress the development of fatty liver. Aim of the Study: To clarify the function of Egr1 on the inflammation and fibrosis in high glucose-cultured MCs, as well as to explore the effects of metformin on miR-34a pathway and Egr1 expression. Methods: We transfected MCs with miR-34a inhibitor...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29679755/long-non-coding-rna-xist-sponges-mir-34a-to-promotes-colon-cancer-progression-via-wnt-%C3%AE-catenin-signaling-pathway
#20
Ningning Sun, Guozun Zhang, Yingying Liu
Little is known about the role of long non-coding RNA XIST in the development of colon cancer. The aim of the present study was to investigate the levels of XIST in colon cancer, and explore its underlying mechanism. In this study, we found XIST expression level was upregulated in colon cancer tissues and cell lines. In addition, the growth rate of cells transfected with si-XIST was significantly decreased compared to that with si-NC, which was reversed by miR-34a targeted with 3'-UTR. Moreover, miR-34a suppressed the expression of WNT1 by binding with the 3'-UTR, which interact with WNT1 to inhibit the proliferation of cells...
April 18, 2018: Gene
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