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miR-34a

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https://www.readbyqxmd.com/read/29163823/myc-is-downregulated-by-a-mitochondrial-checkpoint-mechanism
#1
Xiaonan Zhang, Arjan Mofers, Per Hydbring, Maria Hägg Olofsson, Jing Guo, Stig Linder, Padraig D'Arcy
The MYC proto-oncogene serves as a rheostat coupling mitogenic signaling with the activation of genes regulating growth, metabolism and mitochondrial biogenesis. Here we describe a novel link between mitochondria and MYC levels. Perturbation of mitochondrial function using a number of conventional and novel inhibitors resulted in the decreased expression of MYC mRNA. This decrease in MYC mRNA occurred concomitantly with an increase in the levels of tumor-suppressive miRNAs such as members of the let-7 family and miR-34a-5p...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29162901/microrna-449a-modulates-medullary-thymic-epithelial-cell-differentiation
#2
Pengfei Chen, Haohao Zhang, Xiaohua Sun, Yiming Hu, Wenxia Jiang, Zhanjie Liu, Sanhong Liu, Xiaoren Zhang
Medullary thymic epithelial cells (mTECs) ectopically express a diversity of peripheral tissue-restricted antigens (PTAs) and provide unique cues for the expansion, maturation and selection of a repertoire of functionally diverse T lymphocytes. Genetic deletion of all mature microRNAs in thymic epithelial cells (TECs) results in premature thymic involution, progressive disorganisation of the thymic epithelium, and alteration in thymic T cell lineage commitment, consequently eliciting autoimmune disorders. In the present study, we identified that microRNA-449a (miR-449a), a member of miR-449 cluster, regulated mTEC differentiation...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162670/pu-1-deficient-mice-are-resistant-to-thioacetamide-induced-hepatic-fibrosis-pu-1-finely-regulates-sirt1-expression-via-transcriptional-promotion-of-mir-34a-29c-in-hscs
#3
Qing Liu, Yongming Zhang, Songzhu Yang, Yanfang Wu, Jiantao Wang, Weiwei Yu, Yanguo Liu
PU.1 is a critical transcription factor involving in many pathological processes. However, its exact role in activation of hepatic stellate cells (HSCs) and liver fibrosis was rarely reported. Here, we found that, in HSCs of PU.1(+/-) mice, Sirt1 mRNA expression was not changed but Sirt1 protein was significantly increased, suggesting its promoting role in Sirt1 translation. We then isolated HSCs from WT and PU.1(+/-) mice, and the pcDNA-PU.1 expression vector was transfected into PU.1(+/-) HSCs. We checked the levels of miR-34a and miR-29c, two Sirt1-targeting miRNAs, and protein levels of PU...
November 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29147488/the-downregulation-of-atg4b-mediated-by-microrna-34a-34c-5p-suppresses-rapamycin-induced-autophagy
#4
Yaran Wu, Xufang Dai, Zhenhong Ni, Xiaojing Yan, Fengtian He, Jiqin Lian
Objectives: Autophagy-related 4B (ATG4B) plays an important role in the process of autophagy induction. However, the molecular events that govern the expression of ATG4B in this process are not well known. Materials and Methods: Human ATG4B 3'-UTR region (1377 nt) containing miR-34a/miR-34c-5p binding site was amplified by PCR. Luciferase assay was used to assess the activity of reporter genes. Real-time PCR was used to detect the levels of miR-34a and miR-34c-5p...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29146111/microrna-expression-patterns-in-human-anterior-cingulate-and-motor-cortex-a-study-of-dementia-with-lewy-bodies-cases-and-controls
#5
Peter T Nelson, Wang-Xia Wang, Sarah A Janse, Katherine L Thompson
OVERVIEW: MicroRNAs (miRNAs) have been implicated in neurodegenerative diseases including Parkinson's disease and Alzheimer's disease (AD). Here, we evaluated the expression of miRNAs in anterior cingulate (AC; Brodmann area [BA] 24) and primary motor (MO; BA 4) cortical tissue from aged human brains in the University of Kentucky AD Center autopsy cohort, with a focus on dementia with Lewy bodies (DLB). METHODS: RNA was isolated from gray matter of brain samples with pathology-defined DLB, AD, AD+DLB, and low-pathology controls, with n=52 cases initially included (n=23 with DLB), all with low (<4hrs) postmortem intervals...
November 13, 2017: Brain Research
https://www.readbyqxmd.com/read/29141625/microrna-profiling-of-dogs-with-transitional-cell-carcinoma-of-the-bladder-using-blood-and-urine-samples
#6
Michael S Kent, Allison Zwingenberger, Jodi L Westropp, Laura E Barrett, Blythe P Durbin-Johnson, Paramita Ghosh, Ruth L Vinall
BACKGROUND: Early signs of canine transitional cell carcinoma (TCC) are frequently assumed to be caused by other lower urinary tract diseases (LUTD) such as urinary tract infections, resulting in late diagnosis of TCC which could be fatal. The development of a non-invasive clinical test for TCC could dramatically reduce mortality. To determine whether microRNAs (miRNAs) can be used as non-invasive diagnostic biomarkers, we assessed miRNA expression in blood and/or urine from dogs with clinically normal bladders (n = 28), LUTD (n = 25), and TCC (n = 17)...
November 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29140299/pdgfr%C3%AE-regulated-by-mir-34a-and-foxo1-promotes-adipogenesis-in-porcine-intramuscular-preadipocytes-through-erk-signaling-pathway
#7
Yun-Mei Sun, Jin Qin, Shu-Ge Liu, Rui Cai, Xiao-Chang Chen, Xiang-Ming Wang, Wei-Jun Pang
Suitable intramuscular fat (IMF) content improves porcine meat quality. The vital genes regulating IMF deposition are necessary for the selection and breeding of an IMF trait. However, the effect and mechanism of PDGFRα on IMF deposition are still unclear. Here, PDGFRα is moderately expressed in porcine longissimus dorsi muscle (LD), whereas it highly expressed in white adipose tissue (WAT). Moreover, PDGFRα-positive cells were located in the gaps of LD fibers which there were IMF adipocytes. Compared with 180-day-old and lean-type pigs, the levels of PDGFRα were much higher in one-day-old and fat-type pigs...
November 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29132874/combining-serum-microrna-and-ca-125-as-prognostic-indicators-of-preoperative-surgical-outcome-in-women-with-high-grade-serous-ovarian-cancer
#8
Jaynish S Shah, Gregory B Gard, Jean Yang, Jayne Maidens, Susan Valmadre, Patsy S Soon, Deborah J Marsh
OBJECTIVES: The most widely used approach for the clinical management of women with high-grade serous ovarian cancer (HGSOC) is surgery, followed by platinum and taxane based chemotherapy. The degree of macroscopic disease remaining at the conclusion of surgery is a key prognostic factor determining progression free and overall survival. We sought to develop a non-invasive test to assist surgeons to determine the likelihood of achieving complete surgical resection. This knowledge could be used to plan surgical approaches for optimal clinical management...
November 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29128636/identification-of-key-micrornas-associated-with-diffuse-large-b-cell-lymphoma-by-analyzing-serum-microrna-expressions
#9
Yuanyuan Meng, Lina Quan, Aichun Liu
PURPOSE: This study aimed to investigate the molecular mechanism underlying diffuse large B-cell lymphoma (DLBCL). METHODS: Serum miRNA expression analysis for the serum samples of patients with DLBCL and those of controls was performed using the Illumina sequencing technology. Differentially expressed miRNAs (DEMs) were identified on the basis of the sequencing data. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses and protein-protein interaction (PPI) network construction for the target genes of DEMs were also conducted...
November 8, 2017: Gene
https://www.readbyqxmd.com/read/29128099/regulation-of-cellular-senescence-by-mir-34a-in-alcoholic-liver-injury
#10
Ying Wan, Kelly McDaniel, Nan Wu, Sugeily Ramos-Lorenzo, Trenton Glaser, Julie Venter, Heather Francis, Lindsey Kennedy, Keisaku Sato, Tianhao Zhou, Konstantina Kyritsi, Qiaobing Huang, Tami Annable, Chaodong Wu, Shannon Glaser, Gianfranco Alpini, Fanyin Meng
Alcoholic liver disease remains a major cause of liver-related morbidity and mortality, which ranges from alcoholic steatohepatitis to fibrosis/cirrhosis and hepatocellular carcinoma, and the related mechanisms are understood poorly. In this study, we aimed to investigate the role of miR-34a in alcohol-induced cellular senescence and liver fibrosis. We found that hepatic miR-34a expression was upregulated in ethanol-fed mice and heavy drinkers with steatohepatitis compared with respective controls. Mice treated with miR-34a Vivo-Morpholino developed less severe liver fibrosis than wild-type mice after 5 weeks of ethanol feeding...
November 2, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29127368/diagnostic-value-of-blood-derived-micrornas-for-schizophrenia-results-of-a-meta-analysis-and-validation
#11
Sha Liu, Fuquan Zhang, Xijin Wang, Yin Yao Shugart, Yingying Zhao, Xinrong Li, Zhifen Liu, Ning Sun, Chunxia Yang, Kerang Zhang, Weihua Yue, Xin Yu, Yong Xu
There is an increasing interest in searching biomarkers for schizophrenia (SZ) diagnosis, which overcomes the drawbacks inherent with the subjective diagnostic methods. MicroRNA (miRNA) fingerprints have been explored for disease diagnosis. We performed a meta-analysis to examine miRNA diagnostic value for SZ and further validated the meta-analysis results. Using following terms: schizophrenia/SZ, microRNA/miRNA, diagnosis, sensitivity and specificity, we searched databases restricted to English language and reviewed all articles published from January 1990 to October 2016...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29123608/the-effects-of-microrna-34a-regulating-notch-1-nf-%C3%AE%C2%BAb-signaling-pathway-on-lipopolysaccharide-induced-human-umbilical-vein-endothelial-cells
#12
Yun Ge, Man Huang, Yue-Feng Ma
BACKGROUND: Notch-1/NF-κB signaling plays a key role in the cecal ligation and puncture (CLP)-induced sepsis. This study aims to investigate the intervention effects of microRNA-34a (miR-34a) lentivirus regulating Notch-1/NF-κB signaling pathway on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVEC). METHODS: HUVEC were divided into four groups as the following: they were infected with negative control lentivirus (NC group) or miR-34a lentivirus (OE group); LPS (1 μg/mL) was added on the third day on the basis of NC group and OE group for 24 hours (NC+LPS group or OE+LPS group)...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29118269/genetic-architecture-and-regulatory-impact-on-hepatic-microrna-expression-linked-to-immune-and-metabolic-traits
#13
Siriluck Ponsuksili, Nares Trakooljul, Frieder Hadlich, Fiete Haack, Eduard Murani, Klaus Wimmers
Regulation of microRNA (miRNA) expression contributes to a wide range of target gene expression and phenotypes. The miRNA expression in the liver, the central metabolic organ, was examined in 209 pigs, and integrated with haematological and clinical biomarkers of metabolic and overall health, mRNA-target expression levels and single-nucleotide polymorphism (SNP) genotypes. The expression levels of 426 miRNA species correlated with plasma haematological or biochemical traits (r² = |0.19-0.45|, false discovery rate < 5%)...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29113265/cdx2-is-involved-in-microrna-associated-inflammatory-carcinogenesis-in-gastric-cancer
#14
Motonobu Saito, Hirokazu Okayama, Katsuharu Saito, Jin Ando, Kensuke Kumamoto, Izumi Nakamura, Shinji Ohki, Yoshimasa Ishi, Seiichi Takenoshita
The development of gastric cancer is significantly associated with chronic inflammation, such as caused by Helicobacter pylori (H. pylori) infection. Caudal-type homeobox 2 (CDX2) is a homeobox protein involved in intestinal differentiation in normal and in aberrant locations, and is associated with inflammation. The authors of the present study have previously reported that CDX2 may have a suppressive role in the progression and carcinogenesis of gastric carcinoma. In the present study, the authors initially confirmed that a decreased expression of CDX2, as detected by immunohistochemistry, is associated with poor cancer-specific survival in 210 gastric cancer cases, which is consistent with several previously published studies...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29110584/microrna-target-cross-talks-key-players-in-glioblastoma-multiforme
#15
Eman Ali Toraih, Nagwa Mahmoud Aly, Hoda Y Abdallah, Saeed Awad Al-Qahtani, Aly Am Shaalan, Mohammad Hosny Hussein, Manal Said Fawzy
The role of microRNAs in brain cancer is still naive. Some act as oncogene and others as tumor suppressors. Discovery of efficient biomarkers is mandatory to debate that aggressive disease. Bioinformatically selected microRNAs and their targets were investigated to evaluate their putative signature as diagnostic and prognostic biomarkers in primary glioblastoma multiforme. Expression of a panel of seven microRNAs (hsa-miR-34a, hsa-miR-16, hsa-miR-17, hsa-miR-21, hsa-miR-221, hsa-miR-326, and hsa-miR-375) and seven target genes ( E2F3, PI3KCA, TOM34, WNT5A, PDCD4, DFFA, and EGFR) in 43 glioblastoma multiforme specimens were profiled compared to non-cancer tissues via quantitative reverse transcription-polymerase chain reaction...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29108270/s-adenosylmethionine-and-methylthioadenosine-inhibit-cancer-metastasis-by-targeting-microrna-34a-b-methionine-adenosyltransferase-2a-2b-axis
#16
Maria Lauda Tomasi, Carla Cossu, Ylenia Spissu, Andrea Floris, Minjung Ryoo, Ainhoa Iglesias-Ara, Qiang Wang, Stephen J Pandol, Neil A Bhowmick, Ekihiro Seki, Edwin M Posadas, Shelly C Lu
MicroRNA-34a (miR-34a) is down-regulated in colorectal cancers (CRC) and required for interleukin-6 (IL-6)-induced CRC metastasis. Mice lacking miR-34a developed more invasive cancer in a colitis-associated cancer model. In the same model, S-adenosylmethionine (SAMe) and methylthioadenosine (MTA) inhibited IL-6/STAT3 and lowered tumor burden. SAMe and MTA reduce the expression of methionine adenosyltransferase 2A (MAT2A) and there are consensus binding sites for miR-34a/b in the MAT2A 3'UTR. Here we examined whether SAMe/MTA influence miR-34a/b expression and cancer metastasis...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104726/microrna-34a-a-key-regulator-in-the-hallmarks-of-renal-cell-carcinoma
#17
Eman A Toraih, Afaf T Ibrahiem, Manal S Fawzy, Mohammad H Hussein, Saeed Awad M Al-Qahtani, Aly A M Shaalan
Renal cell carcinoma (RCC) incidence has increased over the past two decades. Recent studies reported microRNAs as promising biomarkers for early cancer detection, accurate prognosis, and molecular targets for future treatment. This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. Quantitative real-time PCR for miR-34a and its targets; MET oncogene; gene-regulating apoptosis (TP53INP2 and DFFA); cell proliferation (E2F3); and cell differentiation (SOX2 and TGFB3) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29102917/mir-27b-and-mir-34a-enhance-docetaxel-sensitivity-of-prostate-cancer-cells-through-inhibiting-epithelial-to-mesenchymal-transition-by-targeting-zeb1
#18
Guangwei Zhang, Xin Tian, Yang Li, Zhiqiang Wang, Xiaodong Li, Chaoyang Zhu
Docetaxel resistance is a primary clinical obstacle in the therapy of advanced prostate cancer (PCa). Aberrant expression of miR-27b and miR-34a has been revealed to be implicated in drug resistance of different tumors. Nevertheless, the roles of miR-27b and miR-34a in docetaxel resistance of PCa and their molecular mechanisms are far from being elucidated. In this study, we found that miR-27b and miR-34a were significantly downregulated in docetaxel-resistant PCa cells. Gain-of-function experiments showed that overexpression of miR-27b or miR-34a enhanced docetaxel sensitivity and inhibited EMT in docetaxel-resistant PCa cells...
November 2, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29100431/impact-of-microrna-34a-and-polymorphism-of-its-target-gene-ca9-on-susceptibility-to-uterine-cervical-cancer
#19
Shun-Fa Yang, Yu-Fan Liu, Chao-Wen Cheng, Wei-En Yang, Wea-Lung Lin, Jiunn-Liang Ko, Po-Hui Wang
The purposes of this study were to associate the genetic polymorphisms in carbonic anhydrase (CA) 9 with uterine cervical cancer and identify the clinical implications. Three single-nucleotide polymorphisms (SNPs), rs2071676 (+201, G/A), rs3829078 (+1081, A/G), and rs1048638 (+1584, C/A), and an 18-base-pair deletion/insertion (376del393) in CA9 were examined. We used the Boyden chamber assay to evaluate the influence of CA9 on the migration of cervical cancers. Tissue microarrays were used to evaluate CAIX immunoreactivity and determine its clinical significance...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29095529/the-potential-of-micrornas-as-human-prostate-cancer-biomarkers-a-meta-analysis-of-related-studies
#20
Song Chun-Jiao, Chen Huan, Chen Li-Zhong, Ru Guo-Mei, Guo Jian-Jun, Ding Qian-Nan
Background/Introduction: Prostate cancer (PC) is a very important kind of male malignancies. When PC evolves into a stage of hormone resistance or metastasis, the fatality rate is very high. Currently, discoveries and advances in miRNAs as biomarkers have opened the potential for the diagnosis of PC, especially early diagnosis. miRNAs not only can noninvasively or minimally invasively identify PC, but also can provide the data for optimization and personalization of therapy. Moreover, miRNAs have been shown to play an important role to predict prognosis of PC...
November 2, 2017: Journal of Cellular Biochemistry
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