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copper zinc

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https://www.readbyqxmd.com/read/28212817/in-vivo-toxicity-of-copper-oxide-lead-oxide-and-zinc-oxide-nanoparticles-acting-in-different-combinations-and-its-attenuation-with-a-complex-of-innocuous-bio-protectors
#1
Ilzira A Minigalieva, Boris A Katsnelson, Vladimir G Panov, Larisa I Privalova, Anatoly N Varaksin, Vladimir B Gurvich, Marina P Sutunkova, Vladimir Ya Shur, Ekaterina V Shishkina, Irene E Valamina, Ilya V Zubarev, Oleg H Makeyev, Ekaterina Y Meshtcheryakova, Svetlana V Klinova
Stable suspensions of metal oxide nanoparticles (Me-NPs) obtained by laser ablation of 99.99% pure copper, zinc or lead under a layer of deionized water were used separately, in three binary combinations and a triple combination in two independent experiments on rats. In one of the experiments the rats were instilled with Me-NPs intratracheally (i.t.) (for performing a broncho-alveolar lavage in 24hrs to estimate the cytological and biochemical indices of the response of the lower airways), while in the other, Me-NPs were repeatedly injected intraperitoneally (i...
February 14, 2017: Toxicology
https://www.readbyqxmd.com/read/28209500/theoretical-estimation-of-64-cu-production-with-neutrons-emitted-during-18-f-production-with-a-30mev-medical-cyclotron
#2
Lucrezia Auditore, Ernesto Amato, Sergio Baldari
PURPOSE: This work presents the theoretical estimation of a combined production of (18)F and (64)Cu isotopes for PET applications. (64)Cu production is induced in a secondary target by neutrons emitted during a routine (18)F production with a 30MeV cyclotron: protons are used to produce (18)F by means of the (18)O(p,n)(18)F reaction on a [(18)O]-H2O target (primary target) and the emitted neutrons are used to produce (64)Cu by means of the (64)Zn(n,p)(64)Cu reaction on enriched zinc target (secondary target)...
February 3, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28207797/mutation-increasing-%C3%AE-carotene-concentrations-does-not-adversely-affect-concentrations-of-essential-mineral-elements-in-pepper-fruit
#3
Nasya B Tomlekova, Philip J White, Jacqueline A Thompson, Emil A Penchev, Stephan Nielen
Vitamin and mineral deficiencies are prevalent in human populations throughout the world. Vitamin A deficiency affects hundreds of millions of pre-school age children in low income countries. Fruits of pepper (Capsicum annuum L.) can be a major dietary source of precursors to Vitamin A biosynthesis, such as β-carotene. Recently, pepper breeding programs have introduced the orange-fruited (of) trait of the mutant variety Oranzheva kapiya, which is associated with high fruit β-carotene concentrations, to the mutant variety Albena...
2017: PloS One
https://www.readbyqxmd.com/read/28205080/assessment-of-cu-zn-edta-parenteral-toxicity-in-calves
#4
Luis Emilio Fazzio, Diana Esther Rosa, Sebastian Julio Picco, Guillermo Alberto Mattioli
Copper (Cu) parenteral administration is used in a beef cow-calf operations to prevent or correct Cu deficiency in bovines. At present, Zinc (Zn) salts have been incorporated to complement Cu antioxidant effect. A risk of hepatotoxicity generated by overdose is a negative consequence of injectable Cu application. Cu-Zn EDTA appears as an alternative; however, data about its toxicity is unknown. The aim of this study was to assess toxicity risk of different doses of Cu-Zn EDTA in calves. Thirty two Aberdeen Angus calves of 162 (±20) kg BW were assigned to 4 groups (n = 8), homogeneous in weight, sex, and age...
February 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28197076/structure-and-synaptic-function-of-metal-binding-to-the-amyloid-precursor-protein-and-its-proteolytic-fragments
#5
REVIEW
Klemens Wild, Alexander August, Claus U Pietrzik, Stefan Kins
Alzheimer's disease (AD) is ultimately linked to the amyloid precursor protein (APP). However, current research reveals an important synaptic function of APP and APP-like proteins (APLP1 and 2). In this context various neurotrophic and neuroprotective functions have been reported for the APP proteolytic fragments sAPPα, sAPPβ and the monomeric amyloid-beta peptide (Aβ). APP is a metalloprotein and binds copper and zinc ions. Synaptic activity correlates with a release of these ions into the synaptic cleft and dysregulation of their homeostasis is linked to different neurodegenerative diseases...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28196974/the-efficacy-of-different-anti-microbial-metals-at-preventing-the-formation-of-and-eradicating-bacterial-biofilms-of-pathogenic-indicator-strains
#6
Natalie Gugala, Joe A Lemire, Raymond J Turner
The emergence of multidrug-resistant pathogens and the prevalence of biofilm-related infections have generated a demand for alternative anti-microbial therapies. Metals have not been explored in adequate detail for their capacity to combat infectious disease. Metal compounds can now be found in textiles, medical devices and disinfectants-yet, we know little about their efficacy against specific pathogens. To help fill this knowledge gap, we report on the anti-microbial and antibiofilm activity of seven metals: silver, copper, titanium, gallium, nickel, aluminum and zinc against three bacterial strains, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli...
February 15, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28194267/retinol-%C3%AE-tocopherol-and-selected-minerals-in-breast-milk-of-lactating-women-with-full-term-infants-in-south-korea
#7
Hyesook Kim, Byung-Mun Jung, Bum-Noh Lee, Yun-Je Kim, Ji A Jung, Namsoo Chang
BACKGROUND/OBJECTIVES: This study was performed to measure fat-soluble vitamins and minerals in breast milk of Korean lactating mothers who exclusively breastfed their babies. SUBJECTS/METHODS: Breast milk samples were collected from 334 mothers. Concentrations of retinol and α-tocopherol were analyzed by high performance liquid chromatography ultraviolet spectrometry while concentrations of minerals were measured by inductively coupled plasma optical emission spectrometry...
February 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28193585/the-filter-feeder-dreissena-polymorpha-affects-nutrient-silicon-and-metal-loid-mobilization-from-freshwater-sediments
#8
Jörg Schaller, Britta Planer-Friedrich
Organic sediments in aquatic ecosystems are well known sinks for nutrients, silicon, and metal(loid)s. Organic matter-consuming organisms like invertebrate shredders, grazers, and bioturbators significantly affect element fixation or remobilization by changing redox conditions or binding properties of organic sediments. Little is known about the effect of filter feeders, like the zebra mussel Dreissena polymorpha, an invasive organism in North American and European freshwater ecosystems. A laboratory batch experiment exposing D...
February 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/28193461/gill-structural-integrity-changes-in-fish-deficient-or-excessive-in-dietary-isoleucine-towards-the-modulation-of-tight-junction-protein-inflammation-apoptosis-and-antioxidant-defense-via-nf-%C3%AE%C2%BAb-tor-and-nrf2-signaling-pathways
#9
Lin Feng, Lu Gan, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Ling Tang, Sheng-Yao Kuang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
This study firstly aimed to test the impact of dietary isoleucine (Ile) on tight junction protein, inflammation, apoptosis, antioxidant defense and related signaling molecule gene expression in the gill of fish. Young grass carp (Ctenopharyngodon idella) (weighing 256.8 ± 3.5 g) were fed six diets containing graded levels of Ile, namely, 3.8, 6.6, 9.3, 12.5, 15.2 and 18.5 g/kg diet for 8 weeks. The results firstly revealed that Ile deficiency down-regulated the mRNA expressions of claudin-3, claudin-b, claudin-c, occludin and zonula occludens-1 (ZO-1) and up-regulated the mRNA expression of claudin-12, which led to the intercellular structure damage of fish gill...
February 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28193418/determination-of-the-total-cadmium-copper-lead-and-zinc-concentrations-and-their-labile-species-fraction-in-apple-beverages-by-flow-through-anodic-stripping-chronopotentiometry
#10
Dominika Jedryczko, Paweł Pohl, Maja Welna
An analytical procedure for operationally defined speciation of Cd, Cu, Pb and Zn in apple beverages by anodic stripping chronopotentiometry (ASCP) is presented. Optimal measurement conditions were set down to reliably determine the fraction of the labile metals species. The mean total concentrations of Cu, Pb and Zn were 69±20, 7.3±3.3, and 129±59μgL(-1) in apple juices, and 18±3, 4.2±0.1, 53±5μgL(-1) in apple drinks, respectively. The contributions of the fraction of the ASCP-labile species varied from 43 to 63% (Cu), from 32 to 42% (Pb) and from 38 to 58% (Zn)...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28190893/metalloneurochemistry-and-the-pierian-spring-shallow-draughts-intoxicate-the-brain
#11
Jacob M Goldberg, Andrei Loas, Stephen J Lippard
Metal ions perform critical and diverse functions in nervous system physiology and pathology. The field of metalloneurochemistry aims to understand the mechanistic bases for these varied roles at the molecular level. Here, we review several areas of research that illustrate progress toward achieving this ambitious goal and identify key challenges for the future. We examine the use of lithium as a mood stabilizer, the roles of mobile zinc and copper in the synapse, the interplay of nitric oxide and metals in retrograde signaling, and the regulation of iron homeostasis in the brain...
October 2016: Israel Journal of Chemistry
https://www.readbyqxmd.com/read/28189073/lower-levels-of-persistent-organic-pollutants-metals-and-the-marine-omega-3-fatty-acid-dha-in-farmed-compared-to-wild-atlantic-salmon-salmo-salar
#12
Anne-Katrine Lundebye, Erik-Jan Lock, Josef D Rasinger, Ole Jakob Nøstbakken, Rita Hannisdal, Egil Karlsbakk, Vidar Wennevik, Abdullah S Madhun, Lise Madsen, Ingvild Eide Graff, Robin Ørnsrud
Contaminants and fatty acid levels in farmed- versus wild Atlantic salmon have been a hot topic of debate in terms of food safety. The present study determined dioxins (polychlorinated dibenzo-p-dioxin and dibenzofuran), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), organochlorine pesticides (OCPs), metals and fatty acids in wild and farmed Atlantic salmon. Contaminant levels of dioxins, PCBs, OCPs (DDT, dieldrin, lindane, chlordane, Mirex, and toxaphene), and mercury were higher in wild salmon than in farmed salmon, as were the concentrations of the essential elements selenium, copper, zinc and iron, and the marine omega-3 fatty acid docosahexaenoic acid (DHA)...
February 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28185046/complete-amino-acid-sequence-of-a-copper-zinc-superoxide-dismutase-from-ginger-rhizome
#13
Yuki Nishiyama, Tamo Fukamizo, Kazunari Yoneda, Tomohiro Araki
Superoxide dismutase (SOD) is an antioxidant enzyme protecting cells from oxidative stress. Ginger (Zingiber officinale) is known for its antioxidant properties, however, there are no data on SODs from ginger rhizomes. In this study, we purified SOD from the rhizome of Z. officinale (Zo-SOD) and determined its complete amino acid sequence using N terminal sequencing, amino acid analysis, and de novo sequencing by tandem mass spectrometry. Zo-SOD consists of 151 amino acids with two signature Cu/Zn-SOD motifs and has high similarity to other plant Cu/Zn-SODs...
February 9, 2017: Protein Journal
https://www.readbyqxmd.com/read/28183631/in-vitro-stimulation-of-vascular-endothelial-growth-factor-by-borate-based-glass-fibers-under-dynamic-flow-conditions
#14
Sisi Chen, Qingbo Yang, Richard K Brow, Kun Liu, Katherine A Brow, Yinfa Ma, Honglan Shi
Bioactive borate glass has been recognized to have both hard and soft tissue repair and regeneration capabilities through stimulating both osteogenesis and angiogenesis. However, the underlying biochemical and cellular mechanisms remain unclear. In this study, dynamic flow culturing modules were designed to simulate the micro-environment near the vascular depletion and hyperplasia area in wound-healing regions, thus to better investigate the mechanisms underlying the biocompatibility and functionality of borate-based glass materials...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183061/trace-elements-in-oceanic-pelagic-communities-in-the-western-indian-ocean
#15
Nathalie Bodin, Dora Lesperance, Rona Albert, Stephanie Hollanda, Philippe Michaud, Maxime Degroote, Carine Churlaud, Paco Bustamante
The mineral composition of target and non-target pelagic fish caught by purse-seiners and longliners in the western-central Indian Ocean was determined. From the 10 essential elements analysed, selenium and zinc showed the highest concentrations in swordfish and blue marlin while Indian mackerel appeared as a good source of copper, iron and chrome. All catch had levels of lead and cadmium, two toxic elements, below the maximum sanitary limits. Although some concerns were raised regarding mercury concentrations in the largest species (wahoo, swordfish and blue marlin), molar ratios of mercury and selenium indicate that all oceanic pelagic fish from the western-central Indian Ocean are safe for human consumption...
January 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28182578/review-of-heavy-metal-accumulation-on-aquatic-environment-in-northern-east-mediterrenean-sea-part-i-some-essential-metals
#16
Ayşe Bahar Yılmaz, Alper Yanar, Ela Nur Alkan
All pollutants can reach the aquatic environments and the levels of heavy metals in upper members of the food web like fish can reach values many times higher than those found in aquatic environment or in sediments. Although heavy metals are essential or non-essential, all heavy metals are potentially harmful to humans and most organisms at some level of exposure and absorption. Marine organisms are good indicators for long-term monitoring of metal accumulation. The present review study is for evaluation of the data from previous studies about the toxic effects of selected heavy metals, like essential metals (copper, zinc, iron, chromium, and manganese), on seawater, sediment, and in different tissues of aquatic animals (demersal and bentic fish, invertabres) collected from different areas in Northern East Mediterrenean Sea since the 1990s...
February 9, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28179340/different-gene-expression-and-activity-pattern-of-antioxidant-enzymes-in-bladder-cancer
#17
Edyta Wieczorek, Zbigniew Jablonowski, Bartlomiej Tomasik, Jolanta Gromadzinska, Ewa Jablonska, Tomasz Konecki, Wojciech Fendler, Marek Sosnowski, Wojciech Wasowicz, Edyta Reszka
The aim of this study was to evaluate the possible role in and contribution of antioxidant enzymes to bladder cancer (BC) etiology and recurrence after transurethral resection (TUR). We enrolled 40 patients with BC who underwent TUR and 100 sex- and age-matched healthy controls. The analysis was performed at diagnosis and recurrence, taking into account the time of recurrence. Gene expression of catalase (CAT), glutathione peroxidase 1 (GPX1) and manganese superoxide dismutase (SOD2) was determined in peripheral blood leukocytes...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178636/comparison-of-three-corrosion-inhibitors-in-simulated-partial-lead-service-line-replacements
#18
Aki Kogo, Sarah Jane Payne, Robert C Andrews
Partial lead service line replacements (PLSLR) were simulated using five recirculating pipe loops treated with either zinc orthophosphate (1mg/L as P), orthophosphate (1mg/L as P) or sodium silicate (10mg/L). Two pipe loops served as "inhibitor-free" (Pb-Cu) and "galvanic free" (Pb-PVC) controls. Changes in water quality (CSMR [0.2 or 1], conductivity [≈330mS/cm or ≈560mS/cm], chlorine [1.4mg/L]) were not observed to provide a significant impact on lead or copper release, although galvanic corrosion was shown to be a driving factor...
January 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28177683/olanzapine-alleviates-oxidative-stress-in-the-liver-of-socially-isolated-rats
#19
Andrijana Stanisavljevic, Ivana Peric, Marija Pantelic, Dragana M Filipovic
Olanzapine, an antipsychotic drug, is used to treat depressive disorder, but its effects on the liver, main site of drug metabolism, still remain elusive. We studied the effects of three weeks of olanzapine treatment (7.5 mg/kg/day) on the malondialdehyde (MDA) and protein carbonyl (PCO) contents, protein expression of copper/zinc superoxide dismutase (CuZnSOD) and activity of total superoxide dismutase (SOD) as well as catalase (CAT) protein expression/activity levels in the liver cytosol of rats exposed to six weeks of chronic social isolation (CSIS), that causes depressive- and anxiety-like behaviors...
December 22, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28176762/systemic-serum-amyloid-a-as-a-biomarker-for-exposure-to-zinc-and-or-copper-containing-metal-fumes
#20
R Baumann, M Gube, A Markert, S Davatgarbenam, V Kossack, B Gerhards, T Kraus, P Brand
Zinc- and copper-containing welding fumes increase systemic C-reactive protein (CRP). The aim of this study was to investigate the performance of the biomarkers serum amyloid A (SAA) and soluble vascular cell adhesion molecule-1 (VCAM-1) in this regard. Fifteen male subjects were exposed under controlled conditions to welding fumes containing either zinc, or copper, or copper and zinc for 6 h. Plasma samples were collected before, 6 and 24 h after start of exposure and biomarkers therein were measured by electrochemiluminescent assay...
February 8, 2017: Journal of Exposure Science & Environmental Epidemiology
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