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https://www.readbyqxmd.com/read/29353326/radiological-and-functional-outcomes-of-high-grade-spondylolisthesis-treated-by-intrasacral-fixation-dome-resection-and-circumferential-fusion-a-retrospective-series-of-20-consecutive-cases-with-a-minimum-of-2%C3%A2-years-follow-up
#1
E Ferrero, B Ilharreborde, V Mas, C Vidal, A-L Simon, K Mazda
PURPOSE: Major concern during surgery for high-grade spondylolisthesis (HGS) is to reduce lumbosacral kyphosis and restore sagittal alignment. Despite the numerous methods described, lumbosacral fixation in HGS is a challenging technique associated with high complication rate. Few series have described outcomes and most of the results are limited to lumbosacral correction without global sagittal alignment analysis. This study aims at analyzing clinical and radiological outcomes of HGS patients treated with intrasacral rods on full spine radiographs...
January 20, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29351877/rest-a-master-transcriptional-regulator-in-neurodegenerative-disease
#2
REVIEW
Jee-Yeon Hwang, R Suzanne Zukin
The restrictive element-1 silencing transcription factor)/NRSF (neuron-restrictive silencing factor (NRSF) is a transcriptional repressor which acts via epigenetic remodeling to silence target genes. Emerging evidence indicates that REST is a master transcriptional regulator of neuron-specific genes not only in neurogenesis and neuronal differentiation, but also in differentiated neurons during the critical period in postnatal brain development, where it plays a role in fine-tuning of genes involved in synaptic plasticity, and in normal aging, where it promotes neuroprotection by repressing genes involved in oxidative stress and β-amyloid toxicity...
January 16, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29346287/development-of-zika-virus-vaccines
#3
REVIEW
Huda Makhluf, Sujan Shresta
Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged as a global threat following the most recent outbreak in Brazil in 2015. ZIKV infection of pregnant women is associated with fetal abnormalities such as microcephaly, and infection of adults can lead to Guillain-Barré syndrome, an autoimmune disease characterized by neurological deficits. Although there are currently licensed vaccines for other flaviviruses, there remains an urgent need for preventative vaccines against ZIKV infection. Herein we describe the current efforts to accelerate the development of ZIKV vaccines using various platforms, including live attenuated virus, inactivated virus, DNA and RNA, viral vectors, and in silico-predicted immunogenic viral epitopes...
January 18, 2018: Vaccines
https://www.readbyqxmd.com/read/29346139/blood-biomarkers-for-evaluation-of-perinatal-encephalopathy-state-of-the-art
#4
Ernest M Graham, Allen D Everett, Jean-Christophe Delpech, Frances J Northington
PURPOSE OF REVIEW: The rapid progress in biomarker science is on the threshold of significantly changing clinical care for infants in the neonatal ICU. Infants with neonatal brain injuries will likely be the first group whose management is dramatically altered with point-of-care, rapidly available brain biomarker analysis. Providing an interim update on progress in this area is the purpose of this review. RECENT FINDINGS: Highlighted findings from the past 18 months of publications on biomarkers in neonatal brain injury include; Specific nonbrain markers of cardiac health and global asphyxia continue to provide information on brain injury after hypoxic-ischemic encephalopathy (HIE)...
January 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29343580/advancing-our-understanding-of-protective-maternal-immunity-as-a-guide-for-development-of-vaccines-to-reduce-congenital-cytomegalovirus-infections
#5
Sallie R Permar, Mark R Schleiss, Stanley A Plotkin
Human cytomegalovirus (HCMV) is the most common congenitally transmitted pathogen worldwide, impacting an estimated 1 million newborns annually. Congenital HCMV (cCMV) infection is a major global contributor to long-term neurologic deficits, including deafness, microcephaly, neurodevelopmental delay, as well as fetal loss and occasional infant mortality. Accordingly, a maternal vaccine to prevent cCMV continues to be a top public health priority. Nevertheless, we remain without a licensed vaccine. Maternal immunity provides partial protection, as the risk of vertical HCMV transmission from chronically infected mothers is reduced compared to settings in which the mother is newly infected during pregnancy...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29342116/vegf-signaling-in-neurological-disorders
#6
REVIEW
Joon W Shim, Joseph R Madsen
Vascular endothelial growth factor (VEGF) is a potent growth factor playing diverse roles in vasculogenesis and angiogenesis. In the brain, VEGF mediates angiogenesis, neural migration and neuroprotection. As a permeability factor, excessive VEGF disrupts intracellular barriers, increases leakage of the choroid plexus endothelia, evokes edema, and activates the inflammatory pathway. Recently, we discovered that a heparin binding epidermal growth factor like growth factor (HB-EGF)-a class of EGF receptor (EGFR) family ligands-contributes to the development of hydrocephalus with subarachnoid hemorrhage through activation of VEGF signaling...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29339773/postural-adaptations-to-unilateral-knee-joint-hypomobility-induced-by-orthosis-wear-during-gait-initiation
#7
A Delafontaine, P Fourcade, J L Honeine, S Ditcharles, E Yiou
Balance control and whole-body progression during gait initiation (GI) involve knee-joint mobility. Single knee-joint hypomobility often occurs with aging, orthopedics or neurological conditions. The goal of the present study was to investigate the capacity of the CNS to adapt GI organization to single knee-joint hypomobility induced by the wear of an orthosis. Twenty-seven healthy adults performed a GI series on a force-plate in the following conditions: without orthosis ("control"), with knee orthosis over the swing leg ("orth-swing") and with the orthosis over the contralateral stance leg ("orth-stance")...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339258/relationship-between-very-early-brain-structure-and-neuromotor-neurological-and-neurobehavioral-function-in-infants-born-31%C3%A2-weeks-gestational-age
#8
Joanne M George, Simona Fiori, Jurgen Fripp, Kerstin Pannek, Andrea Guzzetta, Michael David, Robert S Ware, Stephen E Rose, Paul B Colditz, Roslyn N Boyd
AIM: This study aimed to examine associations between structural MRI and concurrent motor, neurological and neurobehavioral measures at 30-32 weeks postmenstrual age (PMA; 'Early'), and at term equivalent age ('Term'). METHOD: In this prospective cohort study, infants underwent Early MRI (n = 119; 73 male; median 32 weeks 1 day PMA) and Term MRI (n = 102; 61 male; median 40 weeks 4 days PMA) at 3 T. Structural images were scored generating white matter (WM), cortical gray matter, deep gray matter, cerebellar and global brain abnormality scores...
January 13, 2018: Early Human Development
https://www.readbyqxmd.com/read/29339224/emerging-souvenirs-clinical-presentation-of-the-returning-traveller-with-imported-arbovirus-infections-in-europe
#9
Isabella Eckerle, Violeta Briciu, Onder Ergonul, Mihaela Lupse, Anna Papa, Amanda Radulescu, Sotirios Tsiodras, Christine Tsitou, Christian Drosten, Véronique Nussenblatt, Chantal Reusken, Louise Sigfrid, Nick J Beeching
BACKGROUND: Arboviruses are an emerging group of viruses that are causing increasing health concerns globally, including in Europe. Clinical presentation usually consists of a non-specific febrile illness that may be accompanied by rash, arthralgia and arthritis and/or with neurological or haemorrhagic syndromes. The range of differential diagnoses of other infectious and non-infectious aetiologies is broad, presenting a challenge for physicians. While knowledge of the geographic distribution of pathogens and the current epidemiological situation, incubation periods, exposure risk factors and vaccination history can help guide the diagnostic approach, the non-specific and variable clinical presentation can delay final diagnosis...
January 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29334774/three-column-osteotomy-for-adult-spine-deformity-comparison-of-outcomes-and-complications-between-kyphosis-and-kyphoscoliosis
#10
Jun Qiao, Lingyan Xiao, Xu Sun, Zhen Liu, Zezhang Zhu, Bangping Qian, Yong Qiu
BACKGROUND: To compare the surgical outcomes and complications between kyphosis and kyphoscoliosis when using three-column osteotomies. METHODS: Adult spine deformity (ASD) patients with three column osteotomies from March 2005 to December 2014 in our center were retrospectively reviewed. Pre- and postoperative standing postero-anterior and lateral radiographs of the entire spine were obtained. Scoliosis Research Society-22 questionnaire [SRS-22] and Oswestry Disability Index [ODI] were administered preoperatively, postoperatively (surveys within 2 months after surgery), and at final follow-up...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29334268/analysis-of-the-development-and-progression-of-carbon-monoxide-poisoning-related-acute-kidney-injury-according-to-the-kidney-disease-improving-global-outcomes-kdigo-criteria
#11
Youn-Jung Kim, Chang Hwan Sohn, Dong-Woo Seo, Bum Jin Oh, Kyoung Soo Lim, Jai Won Chang, Won Young Kim
CONTEXT: Acute kidney injury (AKI) can occur after carbon monoxide (CO) intoxication; however, limited data are available. This study aimed to evaluate the prognostic value of the development and progression of AKI in patients with acute CO poisoning. MATERIALS AND METHODS: We conducted a retrospective cohort study using a prospective registry of CO poisoning between January 2010 and December 2015. AKI was defined and classified according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria...
January 15, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29327279/emotion-recognition-and-psychological-comorbidity-in-friedreich-s-ataxia
#12
Teresa Costabile, Veronica Capretti, Filomena Abate, Agnese Liguori, Francesca Paciello, Chiara Pane, Anna De Rosa, Silvio Peluso, Giuseppe De Michele, Alessandro Filla, Francesco Saccà
Friedreich's ataxia (FRDA) is an autosomal recessive disease presenting with ataxia, corticospinal signs, peripheral neuropathy, and cardiac abnormalities. Little effort has been made to understand the psychological and emotional burden of the disease. The aim of our study was to measure patients' ability to recognize emotions using visual and non-verbal auditory hints, and to correlate this ability with psychological, neuropsychological, and neurological variables. We included 20 patients with FRDA, and 20 age, sex, and education matched healthy controls (HC)...
January 11, 2018: Cerebellum
https://www.readbyqxmd.com/read/29322980/neurology-of-renal-disorders
#13
Pushpendra N Renjen, Dinesh Chaudhari, Gaurav Sagar, Sanjiv Jasuja
Chronic kidney disease (CKD) is a critical and rapidly growing global health problem. Neurological complications occur in almost all patients with severe CKD, potentially affecting all levels of the nervous system, from the central nervous system (CNS) through to the peripheral nervous system (PNS). Patients with CKD exhibit a high incidence of symptomatic and occult cerebrovascular diseases, associated tremendously high levels of inflammatory factors and homocysteine, as well as anemia, hypertension, and diabetes...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322063/neurological-sequelae-of-adult-meningitis-in-africa-a-systematic-literature-review
#14
REVIEW
Drew W Goldberg, Mark W Tenforde, Hannah K Mitchell, Joseph N Jarvis
The high human immunodeficiency virus (HIV) prevalence in sub-Saharan Africa has markedly changed the epidemiology and presentation of adult meningitis. We conducted a systematic review using PubMed, Embase, Ovid, CENTRAL, and African Index Medicus to identify studies in Africa with data on neurological outcomes in adults after meningitis. We found 22 articles meeting inclusion criteria. From 4 studies with predominately pneumococcal meningitis, a median of 19% of survivors experienced hearing loss up to 40 days...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29321200/bilateral-haemorrhagic-basal-ganglia-infarction-associated-with-early-onset-group-b-streptococcus-meningitis
#15
Rajesh Gupta, Taiwo Maraiyesa, Brendon Conry
A 2-day-old infant presented with poor feeding and grunting. Investigations revealed a raised C reactive protein of 164. Full septic screen was done, which subsequently confirmed a diagnosis of group B streptococcus meningitis. Baby was apyrexial and haemodynamically stable. There were no obvious neurological manifestations, and a routine cranial ultrasound scan was done, which revealed echogenic changes in the basal ganglia and thalami. MRI brain showed extensive haemorrhagic infarction within the lentiform and caudate nuclei with involvement of both posterior limbs of the internal capsule...
January 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29321180/two-year-neurodevelopmental-outcomes-of-extremely-preterm-infants-treated-with-early-hydrocortisone-treatment-effect-according-to-gestational-age-at-birth
#16
Olivier Baud, Clémence Trousson, Valérie Biran, Emilie Leroy, Damir Mohamed, Corinne Alberti
OBJECTIVE: To determine whether early hydrocortisone treatment in extremely preterm infants affects neurodevelopmental outcomes at 2 years of age according to gestational age at birth. PATIENTS AND METHODS: This is an exploratory analysis of neurodevelopmental outcomes by gestational age strata from the PREMILOC trial, in which patients were randomly assigned to receive either placebo or low-dose hydrocortisone and randomisation was stratified by gestational age groups (24-25 and 26-27 weeks of gestation)...
January 10, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29314284/the-mercury-problem-in-artisanal-and-small-scale-gold-mining
#17
Louisa J Esdaile, Justin M Chalker
Mercury-dependent artisanal and small-scale gold mining (ASGM) is the largest source of mercury pollution on Earth. In this practice, elemental mercury is used to extract gold from ore as an amalgam. The amalgam is typically isolated by hand and then heated-often with a torch or over a stove-to distill the mercury and isolate the gold. Mercury emissions from tailings and vaporised mercury exceed 1000 tonnes each year from ASGM. The health effects on the miners are dire, with inhaled mercury leading to neurological damage and other health issues...
January 3, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29313799/astrocytic-modulation-of-excitatory-synaptic-signaling-in-a-mouse-model-of-rett-syndrome
#18
Benjamin Rakela, Paul Brehm, Gail Mandel
Studies linking mutations in Methyl CpG Binding Protein 2 (MeCP2) to physiological defects in the neurological disease, Rett syndrome, have focused largely upon neuronal dysfunction despite MeCP2 ubiquitous expression. Here we explore roles for astrocytes in neuronal network function using cortical slice recordings. We find that astrocyte stimulation in wild-type mice increases excitatory synaptic activity that is absent in male mice lacking MeCP2 globally. To determine the cellular basis of the defect, we exploit a female mouse model for Rett syndrome that expresses wild-type MeCP2-GFP in a mosaic distribution throughout the brain, allowing us to test all combinations of wild-type and mutant cells...
January 9, 2018: ELife
https://www.readbyqxmd.com/read/29306595/hyperglycemia-alters-expression-of-cerebral-metabolic-genes-after-cardiac-arrest
#19
Rickard Per Fredrik Lindblom, Maria Molnar, Charlotte Israelsson, Belinda Röjsäter, Lars Wiklund, Fredrik Lennmyr
BACKGROUND: Survivors of cardiac arrest often experience neurologic deficits. To date, treatment options are limited. Associated hyperglycemia is believed to further worsen the neurologic outcome. The aim with this study was to characterize expression pathways induced by hyperglycemia in conjunction with global brain ischemia. METHODS: Pigs were randomized to high or normal glucose levels, as regulated by glucose and insulin infusions with target levels of 8.5-10 mM and 4-5...
January 3, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29302326/developmental-assistance-for-child-and-adolescent-mental-health-in-low-and-middle-income-countries-2007-2014-annual-trends-and-allocation-by-sector-project-type-donors-and-recipients
#20
Jasmine Turner, Hugo Pigott, Mark Tomlinson, Mark Jd Jordans
Background: Globally, mental disorders are the leading cause of disability among children and adolescents. To date, there has been no estimate of developmental assistance supporting mental health projects that target children and adolescents (DAMH-CA). This study aimed to identify, describe and analyse DAMH-CA with respect to annual trends (2007-2014), sector, project type, recipient regions, and top donor and recipient countries, and estimate annual DAMH-CA per child/adolescent by region...
December 2017: Journal of Global Health
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