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https://www.readbyqxmd.com/read/28724252/effect-of-operating-conditions-on-speciation-and-bioavailability-of-trace-metals-in-submerged-anaerobic-membrane-bioreactors
#1
Pham Minh Thanh, Balachandran Ketheesan, Yan Zhou, David C Stuckey
This study investigated the effect of changes in pH (7, 6.5 and 6), hydraulic retention time (HRT) (6h, 4h, and 2h), solids retention time (SRT) (100d and 25d) on the speciation of trace metals (TMs) in submerged anaerobic membrane bioreactors (SAMBRs). The results showed that the metal retention capacity of SAMBRs reduced when the pH, HRT and SRT were reduced i.e. up to 21.9%, 39.1%, and 17.1%, respectively, but it was also found that the speciation of these TMs generally shifted towards highly bioavailable fractions i...
July 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28720276/arsenic-removal-by-periphytic-biofilm-and-its-application-combined-with-biochar
#2
Ningyuan Zhu, Jianhong Zhang, Jun Tang, Yan Zhu, Yonghong Wu
A biochar and periphyton-based system (BPS) comprising of a biochar column and a periphyton bioreactor was designed to avoid the toxicity issue associated with removing As(III) from wastewater. Results showed that the periphyton can grow when As(III) is less than 5.0mgL(-1). The BPS obtained a high As(III) removal rate (∼90.2-95.4%) at flow rate=1.0mLmin(-1) and initial concentration of As(III)=2.0mgL(-1). About 60% of the As(III) was pre-treated (adsorbed) in the biochar column and the removal of the remaining As(III) was attributed to the periphyton bioreactor...
July 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28720219/monitoring-leachables-from-single-use-bioreactor-bags-for-mammalian-cell-culture-by-dispersive-liquid-liquid-microextraction-followed-by-ultra-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#3
N Dorival-García, J Bones
A method for the identification of leachables in chemically defined media for CHO cell culture using dispersive liquid-liquid microextraction (DLLME) and UHPLC-MS is described. A Box-Behnken design of experiments (DoE) approach was applied to obtain the optimum extraction conditions of the target analytes. Performance of DLLME as extraction technique was studied by comparison of two commercial chemically defined media for CHO cell culture. General extraction conditions for any group of leachables, regardless of their specific chemical functionalities can be applied and similar optimum conditions were obtained with the two media...
July 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28718947/relevance-of-bioreactors-and-whole-tissue-cultures-for-the-translation-of-new-therapies-to-humans
#4
Marianna Peroglio, Diana Gaspar, Dimitrios I Zeugolis, Mauro Alini
The purpose of this review is to provide a brief overview of bioreactor-based culture systems as alternatives to conventional two- and three- dimensional counterparts. The role, challenges and future aspirations of bioreactors in the musculoskeletal field (e.g. cartilage, intervertebral disc, tendon and bone) are discussed. Bioreactors, by recapitulating physiological processes, can be used effectively as part of the initial in vitro screening, reducing that way the number of animal required for preclinical assessment, complying with the 3R principles and, in most cases, allowing working with human tissues...
July 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28718059/recent-advances-in-tissue-engineering-strategies-for-the-treatment-of-joint-damage
#5
REVIEW
Makeda K Stephenson, Ashley L Farris, Warren L Grayson
PURPOSE OF REVIEW: While the clinical potential of tissue engineering for treating joint damage has yet to be realized, research and commercialization efforts in the field are geared towards overcoming major obstacles to clinical translation, as well as towards achieving engineered grafts that recapitulate the unique structures, function, and physiology of the joint. In this review, we describe recent advances in technologies aimed at obtaining biomaterials, stem cells, and bioreactors that will enable the development of effective tissue-engineered treatments for repairing joint damage...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28715703/removal-mechanisms-in-aerobic-slurry-bioreactors-for-remediation-of-soils-and-sediments-polluted-with-hydrophobic-organic-compounds-an-overview
#6
REVIEW
Douglas O Pino-Herrera, Yoan Pechaud, David Huguenot, Giovanni Esposito, Eric D van Hullebusch, Mehmet A Oturan
Hydrophobic organic compound (HOC)-contaminated soils are a great environmental and public health concern nowadays. Further research is necessary to develop environmental friendly biotechnologies that allows public and private sectors to implement efficient and adaptable treatment approaches. Aerobic soil-slurry bioreactor technology has emerged as an effective and feasible technique with a high remediation potential, especially for silt and clay soil fractions, which often contain the highest pollutant concentration levels and are usually difficult to remove by implementing conventional methods...
June 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28715697/development-of-simultaneous-nitrification-denitrification-snd-in-biofilm-reactors-with-partially-coupled-a-novel-biodegradable-carrier-for-nitrogen-rich-water-purification
#7
Jing Zhao, Lijuan Feng, Guangfeng Yang, Jincheng Dai, Jun Mu
Development of simultaneous nitrification-denitrification (SND) is a promising approach for nitrogen-rich water purification. Coupling biofilm reactors with novel biodegradable carrier of Pumelo Peel (PP) and various conventional plastic fillers (polyurethane filler, SPR-1 suspension filler, TA-II elastic filler and sphere filler) were examined to achieve SND in this study. Results represented that partially coupled with PP could achieve highly efficient SND. Optimal performance appealed in a bioreactor of coupling PP and SPR-1filler with ammonia and total nitrogen removal efficiencies of 96...
June 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28713407/biorhizome-a-biosynthetic-platform-for-colchicine-biomanufacturing
#8
REVIEW
Ganapathy Sivakumar, Kamran Alba, Gregory C Phillips
Colchicine is one of the oldest plant-based medicines used to treat gout and one of the most important alkaloid-based antimitotic drugs with anticancer potential, which is commercially extracted from Gloriosa superba. Clinical trials suggest that colchicine medication could prevent atrial fibrillation recurrence after cardiac surgery. In addition, therapeutic colchicine is undergoing clinical trials to treat non-diabetic metabolic syndrome and diabetic nephropathy. However, the industrial-scale biomanufacturing of colchicine have not yet been established...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28712957/secretory-expression-of-%C3%AE-mannanase-from-bacillus-circulans-nt-6-7-in-lactobacillus-plantarum
#9
Kwankanit Intaratrukul, Sunee Nitisinprasert, Thu-Ha Nguyen, Dietmar Haltrich, Suttipun Keawsompong
The β-mannanase gene of Bacillus circulans NT 6.7 was successfully cloned in Lactobacillus plantarum WCFS1 using the pSIP403 expression vector and secreted to the supernatant rather than accumulated in the cells. The highest activity was achieved by controlling the pH at 6 during cultivation. Maximum mannanase activities detected in the supernatant and cell-free extract of 200 ml MRS broth were 8.2 and 0.86 U/ml, respectively. Enzyme activity in the supernatant increased to 27 U/ml by fermentation in a 5-L bioreactor with automatic pH control...
July 13, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28712782/cu-removal-and-response-mechanisms-of-periphytic-biofilms-in-a-tubular-bioreactor
#10
Lan Ma, Fengwu Wang, Yuanchun Yu, Junzhuo Liu, Yonghong Wu
This work studied Cu removal and response mechanisms of periphytic biofilms in a tubular bioreactor. Periphytic biofilms immobilized in a tubular bioreactor were used to remove Cu from wastewater with different Cu concentrations. Results showed that periphytic biofilms had a high removal efficiency (max. 99%) at a hydraulic retention time (HRT) of 12h under initial Cu concentrations of 2.0 and 10.0mgL(-1). Periphyton quickly adapted to Cu stress by regulating the community composition. Species richness, evenness and carbon metabolic diversity of the periphytic community increased when exposed to Cu...
July 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28712332/comparison-of-commercial-baker-s-yeast-versus-bacteria-based-membrane-bioreactors-for-landfill-leachate-treatment
#11
M C S Amaral, G C B Brito, B G Reis, L C Lange, W G Moravia
This paper compares the performance of the membrane bioreactor (MBR) inoculated with commercial baker's yeast (Saccharomyces cerevisiae) (MBRy) versus one inoculated with bacterial sludge (MBRb) for treatment of landfill leachate (LFL). The MBRb and MBRy were operated with a hydraulic retention time (HRT) of 48 h, solids retention time (SRT) of 60 d, and specific air demand based on membrane area (SADm) of 0.6 m(3) h(-1) m(-2). The MBRy was more efficient in removing COD (68 ± 12%), color (79 ± 8%), ammoniacal nitrogen (58 ± 18%), and phosphorus (62 ± 19%) compared to MBRb, which showed removal efficiencies of 44 ± 18%, 46 ± 20%, 45 ± 17%, and 29 ± 15% for COD, color, ammoniacal nitrogen, and phosphorus...
July 17, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28711803/investigation-on-the-response-of-anaerobic-membrane-bioreactor-to-temperature-decrease-from-25%C3%A2-c-to-10%C3%A2-c-in-sewage-treatment
#12
Ryoya Watanabe, Yulun Nie, Shinichiro Wakahara, Daisuke Komori, Yu-You Li
Anaerobic membrane bioreactor (AnMBR) for sewage treatment was operated for 650days with the decrease of temperature from 25°C to 10°C. At higher temperature >15°C, COD removal was above 94% while sewage treatment efficiency and relevant CH4 production decreased below 15°C. The effluent COD at 10°C was 134mg/L at HRT of 16h. Moreover, low temperature can result in a higher membrane fouling rate due to the microbial self-protection behavior in coping with the temperature decrease by releasing soluble microbial products (SMP) and extracellular polymeric substances (EPS)...
July 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28711802/two-stage-anoxic-oxic-combined-membrane-bioreactor-system-for-landfill-leachate-treatment-pollutant-removal-performances-and-microbial-community
#13
Jianbo Liu, Haibo Zhang, Panyue Zhang, Yan Wu, Xiying Gou, Yonghui Song, Zhiyong Tian, Guangming Zeng
In this study, a laboratory-scale two-stage anoxic/oxic (A/O) combined membrane bioreactor (MBR) was operated for 113d for the treatment of landfill leachate. The average removal of chemical oxygen demand (COD), ammonia (NH4(+)-N) and total nitrogen (TN) achieved 80.60%, 99.04% and 74.87%, respectively. A mass balance evaluation suggested that the removal of COD, NH4(+)-N and TN occurred mainly in the second A/O process, and the total removal capacity of COD, NH4(+)-N and TN were 125.60g/d, 24.35g/d and 22...
July 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28711673/on-line-prediction-of-the-glucose-concentration-of-cho-cell-cultivations-by-nir-and-raman-spectroscopy-comparative-scalability-test-with-a-shake-flask-model-system
#14
Bence Kozma, Edit Hirsch, Szilveszter Gergely, László Párta, Hajnalka Pataki, András Salgó
In this study, near-infrared (NIR) and Raman spectroscopy were compared in parallel to predict the glucose concentration of Chinese hamster ovary cell cultivations. A shake flask model system was used to quickly generate spectra similar to bioreactor cultivations therefore accelerating the development of a working model prior to actual cultivations. Automated variable selection and several pre-processing methods were tested iteratively during model development using spectra from six shake flask cultivations...
July 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28710634/obtaining-of-11%C3%AE-hydroxyandrost-4-ene-3-17-dione-from-natural-sterols
#15
Dmitry Dovbnya, Sergey Khomutov, Vyacheslav Kollerov, Marina V Donova
Two-step one-pot microbial transformation enables obtaining of valuable steroids that are difficult to produce chemically. Here we describe a method for obtaining 11α-hydroxyandrost-4-ene-3,17-dione (11α-HAD) from cheap and available natural sterols (phytosterols or cholesterol).11α-HAD is a primary adrenal steroid in mammals and also a key precursor in the syntheses of halogenated corticoids. Conventional routes for its obtaining are based on chemical synthesis, or microbial hydroxylation of androst-4-ene-3,17-dione (AD)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28710628/%C3%AE-sitosterol-bioconversion-to-androstenedione-in-microtiter-plates
#16
Marco P C Marques, Pedro Fernandes
Microtiter plates are routinely used as low-cost miniaturized bioreactors due to the large number of experiments that can be conducted simultaneously under similar conditions and replicate all functions of bench-scale reactors at dramatically smaller volumes. These plates, due to the standard footprint, can be integrated with liquid-handling systems and associated equipment expanding considerably their application and use. However, care has to be taken to operate the microtiter plates in optimized mixing and oxygen transfer conditions, preventing medium evaporation in prolonged experiment runs...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28710568/microbial-community-analysis-of-simultaneous-ammonium-removal-and-fe-3-reduction-at-different-influent-ammonium-concentrations
#17
Jun Feng Su, Ting Ting Lian, Ting Lin Huang, Dong Hui Liang, Li Wei, Wen Dong Wang
This study investigates the impacts of influent ammonium concentrations on the microbial community in immobilized heterotrophic ammonium removal system. Klebsiella sp. FC61, the immobilized species, has the ability to perform simultaneous ammonium removal and Fe(3+) reduction. It was found that average ammonium removal rate decreased from 0.308 to 0.157 mg/L/h, as the influent NH4(+)-N was reduced from 20 to 10 mg/L. Meanwhile, at a total Fe(3+) concentration of 20 mg/L, the average Fe(3+) reduction removal efficiency and rate decreased from 44...
July 14, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28709885/modeling-of-acetate-type-fermentation-of-sugar-containing-wastewater-under-acidic-ph-conditions
#18
Liang Huang, Xin-Rong Pan, Ya-Zhou Wang, Chen-Xuan Li, Chang-Bin Chen, Quan-Bao Zhao, Yang Mu, Han-Qing Yu, Wen-Wei Li
In this study, a kinetic model was developed based on Anaerobic Digestion Model No. 1 to provide insights into the directed production of acetate and methane from sugar-containing wastewater under low pH conditions. The model sufficiently described the dynamics of liquid-phase and gaseous products in an anaerobic membrane bioreactor by comprehensively considering the syntrophic bioconversion steps of sucrose hydrolysis, acidogenesis, acetogenesis and methanogenesis under acidic pH conditions. The modeling results revealed a significant pH-dependency of hydrogenotrophic methanogenesis and ethanol-producing processes that govern the sucrose fermentative pathway through changing the hydrogen yield...
June 16, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28709754/nondestructive-mechanical-characterization-of-developing-biological-tissues-using-inflation-testing
#19
P J A Oomen, M A J van Kelle, C W J Oomens, C V C Bouten, S Loerakker
One of the hallmarks of biological soft tissues is their capacity to grow and remodel in response to changes in their environment. Although it is well-accepted that these processes occur at least partly to maintain a mechanical homeostasis, it remains unclear which mechanical constituent(s) determine(s) mechanical homeostasis. In the current study a nondestructive mechanical test and a two-step inverse analysis method were developed and validated to nondestructively estimate the mechanical properties of biological tissue during tissue culture...
July 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28709104/biological-attenuation-of-arsenic-and-iron-in-a-continuous-flow-bioreactor-treating-acid-mine-drainage-amd
#20
L Fernandez-Rojo, M Héry, P Le Pape, C Braungardt, A Desoeuvre, E Torres, V Tardy, E Resongles, E Laroche, S Delpoux, C Joulian, F Battaglia-Brunet, J Boisson, G Grapin, G Morin, C Casiot
Passive water treatments based on biological attenuation can be effective for arsenic-rich acid mine drainage (AMD). However, the key factors driving the biological processes involved in this attenuation are not well-known. Here, the efficiency of arsenic (As) removal was investigated in a bench-scale continuous flow channel bioreactor treating As-rich AMD (∼30-40 mg L(-1)). In this bioreactor, As removal proceeds via the formation of biogenic precipitates consisting of iron- and arsenic-rich mineral phases encrusting a microbial biofilm...
June 22, 2017: Water Research
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