keyword
MENU ▼
Read by QxMD icon Read
search

REM sleep behaviour disorder

keyword
https://www.readbyqxmd.com/read/27899291/dynamic-changes-in-sleep-pattern-during-post-partum-in-normal-pregnancy-in-rat-model
#1
Neelima Sivadas, Arathi Radhakrishnan, B S Aswathy, Velayudhan Mohan Kumar, Kamalesh K Gulia
To develop an animal model for studies on peri-partum sleep disorders, sleep patterns in female Wistar rats during pregnancy, post-partum and after weaning, were assessed and associated adaptive changes in their anxiety were examined. Adult nulliparous female rats, maintained in standard laboratory conditions with ad libitum food and water, were surgically implanted with electroencephalogram and electromyogram electrodes under anaesthesia for objective assessment of sleep-wakefulness (S-W). After post-surgical recovery, three control recordings of S-W were taken for 24h before the animals were kept for mating...
November 26, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27786242/advances-in-markers-of-prodromal-parkinson-disease
#2
REVIEW
Ronald B Postuma, Daniela Berg
Efforts to develop neuroprotective therapy for Parkinson disease (PD) are focusing on the early stages of disease, which offer the best opportunity to intervene. Early PD can be divided into preclinical, prodromal and clinical stages; in this Review, we focus on the prodromal stage and markers that can be used to identify prodromal PD. We consider the necessary properties of a marker, before providing an overview of the proven and potential markers of prodromal PD, including clinical nonmotor markers, clinical motor markers, neuroimaging markers and tissue biomarkers...
October 27, 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27449005/pramipexole-in-the-treatment-of-rem-sleep-behaviour-disorder-a-critical-review
#3
REVIEW
Shian Ming Tan, Yi Min Wan
While widely accepted as a first-line treatment for rapid eye movement sleep (REM) behaviour disorder, clonazepam (CNZP) has side effects that limit its applicability. Pramipexole is a possible alternative, but limited literature on its effectiveness exists. This review aims to summarize the available data on the use of pramipexole in REM sleep behaviour disorder. A systematic search of major databases was conducted to look for published and on-going trials. This search yielded a total of five articles, all of which are observational in nature...
September 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27297241/basal-ganglia-dysfunction-in-idiopathic-rem-sleep-behaviour-disorder-parallels-that-in-early-parkinson-s-disease
#4
Michal Rolinski, Ludovica Griffanti, Paola Piccini, Andreas A Roussakis, Konrad Szewczyk-Krolikowski, Ricarda A Menke, Timothy Quinnell, Zenobia Zaiwalla, Johannes C Klein, Clare E Mackay, Michele T M Hu
SEE POSTUMA DOI101093/AWW131 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Resting state functional magnetic resonance imaging dysfunction within the basal ganglia network is a feature of early Parkinson's disease and may be a diagnostic biomarker of basal ganglia dysfunction. Currently, it is unclear whether these changes are present in so-called idiopathic rapid eye movement sleep behaviour disorder, a condition associated with a high rate of future conversion to Parkinson's disease. In this study, we explore the utility of resting state functional magnetic resonance imaging to detect basal ganglia network dysfunction in rapid eye movement sleep behaviour disorder...
August 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27103193/high-accuracy-detection-of-early-parkinson-s-disease-through-multimodal-features-and-machine-learning
#5
R Prashanth, Sumantra Dutta Roy, Pravat K Mandal, Shantanu Ghosh
Early (or preclinical) diagnosis of Parkinson's disease (PD) is crucial for its early management as by the time manifestation of clinical symptoms occur, more than 60% of the dopaminergic neurons have already been lost. It is now established that there exists a premotor stage, before the start of these classic motor symptoms, characterized by a constellation of clinical features, mostly non-motor in nature such as Rapid Eye Movement (REM) sleep Behaviour Disorder (RBD) and olfactory loss. In this paper, we use the non-motor features of RBD and olfactory loss, along with other significant biomarkers such as Cerebrospinal fluid (CSF) measurements and dopaminergic imaging markers from 183 healthy normal and 401 early PD subjects, as obtained from the Parkinson's Progression Markers Initiative (PPMI) database, to classify early PD subjects from normal using Naïve Bayes, Support Vector Machine (SVM), Boosted Trees and Random Forests classifiers...
June 2016: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27087472/association-between-rem-sleep-behaviour-disorder-and-impulse-control-disorder-in-patients-with-parkinson-s-disease
#6
E Bellosta Diago, L J Lopez Del Val, S Santos Lasaosa, E López Garcia, A Viloria Alebesque
INTRODUCTION: The relationship between impulse control disorder (ICD) and REM sleep behaviour disorder (RBD) has not yet been clarified, and the literature reports contradictory results. Our purpose is to analyse the association between these 2 disorders and their presence in patients under dopaminergic treatment. METHODS: A total of 73 patients diagnosed with Parkinson's disease and treated with a single dopamine agonist were included in the study after undergoing clinical assessment and completing the single-question screen for REM sleep behaviour disorder and the short version of the questionnaire for impulsive-compulsive behaviours in Parkinson's disease...
April 14, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/27070245/increased-motor-activity-during-rem-sleep-is-linked-with-dopamine-function-in-idiopathic-rem-sleep-behavior-disorder-and-parkinson-disease
#7
Marielle Zoetmulder, Miki Nikolic, Heidi Biernat, Lise Korbo, Lars Friberg, Poul Jennum
STUDY OBJECTIVES: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by impaired motor inhibition during REM sleep, and dream-enacting behavior. RBD is especially associated with α-synucleinopathies, such as Parkinson disease (PD). Follow-up studies have shown that patients with idiopathic RBD (iRBD) have an increased risk of developing an α-synucleinopathy in later life. Although abundant studies have shown that degeneration of the nigrostriatal dopaminergic system is associated with daytime motor function in Parkinson disease, only few studies have investigated the relation between this system and electromyographic (EMG) activity during sleep...
June 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27060683/the-anatomical-cellular-and-synaptic-basis-of-motor-atonia-during-rapid-eye-movement-sleep
#8
Elda Arrigoni, Michael C Chen, Patrick M Fuller
Rapid eye movement (REM) sleep is a recurring part of the sleep-wake cycle characterized by fast, desynchronized rhythms in the electroencephalogram (EEG), hippocampal theta activity, rapid eye movements, autonomic activation and loss of postural muscle tone (atonia). The brain circuitry governing REM sleep is located in the pontine and medullary brainstem and includes ascending and descending projections that regulate the EEG and motor components of REM sleep. The descending signal for postural muscle atonia during REM sleep is thought to originate from glutamatergic neurons of the sublaterodorsal nucleus (SLD), which in turn activate glycinergic pre-motor neurons in the spinal cord and/or ventromedial medulla to inhibit motor neurons...
October 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27051076/dream-recall-frequencies-and-dream-content-in-wilson-s-disease-with-and-without-rem-sleep-behaviour-disorder-a-neurooneirologic-study
#9
Gotthard G Tribl, Mateus C Trindade, Michael Schredl, Joana Pires, Iris Reinhard, Thais Bittencourt, Geraldo Lorenzi-Filho, Rosana Cardoso Alves, Daniel Ciampi de Andrade, Erich T Fonoff, Edson Bor-Seng-Shu, Alexandre A Machado, Manoel J Teixeira, Egberto R Barbosa
Objective. Violent dream content and its acting out during rapid eye movement sleep are considered distinctive for rapid eye movement sleep behaviour disorder (RBD). This study reports first quantitative data on dreaming in a cohort of patients with treated Wilson's disease (WD) and in patients with WD with RBD. Methods. Retrospective questionnaires on different dimensions of dreaming and a prospective two-week home dream diary with self-rating of emotions and blinded, categorical rating of content by an external judge...
2016: Behavioural Neurology
https://www.readbyqxmd.com/read/27010071/pharmacological-interventions-for-daytime-sleepiness-and-sleep-disorders-in-parkinson-s-disease-systematic-review-and-meta-analysis
#10
REVIEW
Tiago Martins Rodrigues, Ana Castro Caldas, Joaquim J Ferreira
BACKGROUND: Daytime sleepiness and sleep disorders are frequently reported in Parkinson's disease (PD). However, their impact on quality of life has been underestimated and few clinical trials have been performed. OBJECTIVES: We aimed to assess the efficacy and safety of pharmacological interventions for daytime sleepiness and sleep disorders in PD. METHODS: Systematic review of randomized controlled trials comparing any pharmacological intervention with no intervention or placebo for the treatment of daytime sleepiness and sleep problems in PD patients...
June 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/26971662/idiopathic-rapid-eye-movement-sleep-behaviour-disorder-diagnosis-management-and-the-need-for-neuroprotective-interventions
#11
REVIEW
Alex Iranzo, Joan Santamaria, Eduardo Tolosa
Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) manifests as unpleasant dreams and vigorous behaviours during REM sleep that can result in injuries. Patients with IRBD have no known neurological diseases or motor or cognitive complaints; however, this sleep disorder is not harmless. In most cases, IRBD is the prelude of the synucleinopathies Parkinson's disease, dementia with Lewy bodies, or, less frequently, multiple system atrophy. Patients can show abnormalities that are characteristic of the synucleinopathies, and longitudinal follow-up shows that most patients develop parkinsonism and cognitive impairments with time...
April 2016: Lancet Neurology
https://www.readbyqxmd.com/read/26961981/-the-competence-network-parkinson-cnp
#12
Wolfgang H Oertel, Guenther Deuschl, Karla Eggert
The Competence Network Parkinson (CNP) is a research infrastructure for disease-oriented translational and clinical research in the field of Parkinson syndromes (PS). It was initiated in 1999 and funded until 2008 by the German Ministry for Education and Research (BMBF). The CNP created a highly frequented website with information on PS for the general public and for experts. The CNP designed and established one of the first electronic internet-based data entry systems (secuTrial®) - fulfilling the legal standards of data safety and security - a material bank for genetic research on Parkinson's disease (PD), implemented and investigated new methods for early diagnosis of PD and related atypical PS including in vivo dopamine transporter imaging (DAT SPECT), established the German Parkinson Study Group (GPS-Pharma) with 40 certified trial centres for pharmacotherapeutical trials and the German interdisciplinary Parkinson Study Group (neurology and neurosurgery) for deep brain stimulation (GPS-DBS), and carried out several pharmacoeconomic and health care studies on PD in Germany...
April 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/26842960/dysautonomia-in-prodromal-%C3%AE-synucleinopathy-peripheral-versus-central-autonomic-degeneration
#13
C Dahms, A Guenther, M Schwab, T Schultze, S Nowack, D Hoyer, J Ehrhardt, O W Witte, G Mayer, S Rupprecht
BACKGROUND AND PURPOSE: There is an urgent need for early predictive markers for the course of disease in prodromal α-synucleinopathies such as idiopathic rapid eye movement (REM) sleep behaviour disorder. Autonomic cardiac/vascular dysfunction is a prominent feature in advanced α-synucleinopathies, but its diagnostic value as an early neurodegenerative marker remains unclear. The latter may be complicated since synuclein-mediated neurodegeneration may involve central and peripheral components of the autonomic nervous system...
May 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/26780965/rapid-eye-movement-sleep-behaviour-disorder-symptomatic-of-a-brain-stem-cavernoma
#14
Sandra Felix, Stephane Thobois, Laure Peter-Derex
A 75-year-old man complained of excessive daytime sleepiness (EDS), difficulty falling asleep and nocturnal agitation during sleep. Restless legs syndrome (RLS) was diagnosed and treated. Because of persistent EDS, snoring and nycturia, a nocturnal polysomnography (PSG) was performed. PSG showed high sleep fragmentation related to a moderate to severe obstructive sleep apnea syndrome. Continuous positive airway pressure treatment (CPAP) was proposed. Because of the persistence of abnormal nocturnal behaviours, characterized by screaming, punching and falling out of bed, a video-PSG with CPAP treatment was performed...
April 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/26736335/eeg-recordings-as-a-source-for-the-detection-of-irbd
#15
Sissel Bisgaard, Bolette Duun-Christensen, Lykke Kempfner, Helge B D Sorensen, Poul Jennum
The purpose of this pilot study was to develop a supportive algorithm for the detection of idiopathic Rapid Eye-Movement (REM) sleep Behaviour Disorder (iRBD) from EEG recordings. iRBD is defined as REM sleep without atonia with no current sign of neurodegenerative disease, and is one of the earliest known biomarkers of Parkinson's Disease (PD). It is currently diagnosed by polysomnography (PSG), primarily based on EMG recordings during REM sleep. The algorithm was developed using data collected from 42 control subjects and 34 iRBD subjects...
August 2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/26725142/non-motor-symptoms-and-cardiac-innervation-in-synj1-related-parkinsonism
#16
A De Rosa, T Pellegrino, S Pappatà, M Lieto, V Bonifati, V Palma, A Topa, L Santoro, L Bilo, A Cuocolo, G De Michele
INTRODUCTION: PARK20 is a rare autosomal recessive parkinsonism related to the SYNJ1 gene and characterized by early-onset of disease and atypical signs such as supranuclear vertical gaze palsy, dementia, dystonia, and generalized tonic-clonic seizures. OBJECTIVE: Non-motor features and cardiac sympathetic innervation were assessed in two siblings affected by parkinsonism who harboured the homozygous Arg258Gln mutation in the SYNJ1 gene. METHODS: The Non-Motor Symptoms, the SCOPA-AUT, the Mayo Sleep Questionnaires and polysomnography were used to investigate non-motor signs (NMS), autonomic dysfunction and REM Behavioural Disorder (RBD)...
February 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/26599301/oculo-visual-dysfunction-in-parkinson-s-disease
#17
REVIEW
R A Armstrong
This review describes the oculo-visual problems likely to be encountered in Parkinson's disease (PD) with special reference to three questions: (1) are there visual symptoms characteristic of the prodromal phase of PD, (2) is PD dementia associated with specific visual changes, and (3) can visual symptoms help in the differential diagnosis of the parkinsonian syndromes, viz. PD, progressive supranuclear palsy (PSP), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and corticobasal degeneration (CBD)? Oculo-visual dysfunction in PD can involve visual acuity, dynamic contrast sensitivity, colour discrimination, pupil reactivity, eye movement, motion perception, and visual processing speeds...
2015: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/26582557/visual-short-term-memory-deficits-in-rem-sleep-behaviour-disorder-mirror-those-in-parkinson-s-disease
#18
Michal Rolinski, Nahid Zokaei, Fahd Baig, Kathrin Giehl, Timothy Quinnell, Zenobia Zaiwalla, Clare E Mackay, Masud Husain, Michele T M Hu
Individuals with REM sleep behaviour disorder are at significantly higher risk of developing Parkinson's disease. Here we examined visual short-term memory deficits--long associated with Parkinson's disease--in patients with REM sleep behaviour disorder without Parkinson's disease using a novel task that measures recall precision. Visual short-term memory for sequentially presented coloured bars of different orientation was assessed in 21 patients with polysomnography-proven idiopathic REM sleep behaviour disorder, 26 cases with early Parkinson's disease and 26 healthy controls...
January 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26559218/-sleep-medicine-1965%C3%A2-to%C3%A2-2015
#19
Jacques Montplaisir
The Département de psychiatrie de l'Université de Montréal houses one of the first sleep centers founded 40 years ago. This center contributed to virtually every aspect of sleep medicine. It grew considerably over time to become one of the largest sleep centers worldwide. It is now called the Center for Advanced Research in Sleep Medicine (CARSM). Fourteen researchers and more than 30 research PhDs and postdoctoral fellows are working together in a 1,500 square-meter facility that includes separate units for fundamental and clinical studies and for the sleep disorders clinic...
2015: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/26551998/higher-frequency-and-complexity-of-sleep-disturbances-in-dementia-with-lewy-bodies-as-compared-to-alzheimer-s-disease
#20
Luiza Chwiszczuk, Monica Breitve, Minna Hynninen, Michaela D Gjerstad, Dag Aarsland, Arvid Rongve
BACKGROUND: Sleep disturbances (SDs) are common in patients with all forms of dementia. However, most studies focus on Alzheimer's disease (AD) and less is known about the prevalence and characteristics of SD in dementia with Lewy bodies (DLB). OBJECTIVE: The aims of this cross-sectional study were: (1) to examine the frequency of SD in DLB versus AD; (2) to compare patients with and without SD with regard to relevant clinical variables, and (3) to investigate the associations between SD and medication use...
2016: Neuro-degenerative Diseases
keyword
keyword
52322
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"