keyword
https://read.qxmd.com/read/38502973/mitochondrial-dna-deletions-in-the-cerebrospinal-fluid-of-patients-with-idiopathic-rem-sleep-behaviour-disorder
#1
JOURNAL ARTICLE
Margalida Puigròs, Anna Calderon, Daniel Martín-Ruiz, Mònica Serradell, Manel Fernández, Amaia Muñoz-Lopetegi, Gerard Mayà, Joan Santamaria, Carles Gaig, Anna Colell, Eduard Tolosa, Alex Iranzo, Ramon Trullas
BACKGROUND: Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) represents the prodromal stage of Lewy body disorders (Parkinson's disease (PD) and dementia with Lewy bodies (DLB)) which are linked to variations in circulating cell-free mitochondrial DNA (cf-mtDNA). Here, we assessed whether altered cf-mtDNA release and integrity are already present in IRBD. METHODS: We used multiplex digital PCR (dPCR) to quantify cf-mtDNA copies and deletion ratio in cerebrospinal fluid (CSF) and serum in a cohort of 71 participants, including 1) 17 patients with IRBD who remained disease-free (non-converters), 2) 34 patients initially diagnosed with IRBD who later developed either PD or DLB (converters), and 3) 20 age-matched controls without IRBD or Parkinsonism...
March 18, 2024: EBioMedicine
https://read.qxmd.com/read/38482468/dreaming-characteristics-in-non-rapid-eye-movement-parasomnia-and-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-similarities-and-differences
#2
JOURNAL ARTICLE
Qi Rui See, Kausar Raheel, Iain Duncan, Nazanin Biabani, Irene Di Giulio, Andrea Romigi, Veena Kumari, David O'Regan, Scott Cairney, Daniele Urso, K Ray Chaudhuri, Valentina Gnoni, Panagis Drakatos, Ivana Rosenzweig
BACKGROUND: Speech graph analysis (SGA) of dreams has recently shown promise as an objective and language-invariant diagnostic tool that can aid neuropsychiatric diagnosis. Whilst the notion that dreaming mentations reflect distinct physiologic processes is not new, such studies in patients with sleep disorders remain exceptionally scarce. Here, using SGA and other dream content analyses, we set to investigate structural and thematic differences in morning dream recalls of patients diagnosed with Non-Rapid Eye Movement Parasomnia (NREMP) and Idiopathic REM Sleep Behavior Disorder (iRBD)...
2024: Nature and Science of Sleep
https://read.qxmd.com/read/38482377/theory-of-mind-impairment-in-childhood-narcolepsy-type-1-a-case-control-study
#3
JOURNAL ARTICLE
Marco Veneruso, Paola Del Sette, Ramona Cordani, Serena Lecce, Fabio Pizza, Lorenzo Chiarella, Cristina Venturino, Lino Nobili, Giuseppe Plazzi
Narcolepsy type 1 is a central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy and other rapid eye movement sleep-related manifestations. Neurophysiological studies suggest that narcolepsy type 1 patients may experience impairment in emotional processing due to structural and functional changes in limbic structures and associated areas. However, the only study exploring narcolepsy behavioural responses found no impairment in the ability to recognize emotions, possibly due to compensatory mechanisms...
2024: Brain communications
https://read.qxmd.com/read/38444905/unraveling-the-directional-relationship-of-sleep-and-migraine-like-pain
#4
JOURNAL ARTICLE
Robson C Lillo Vizin, Caroline M Kopruszinski, Paula M Redman, Hisakatsu Ito, Jill Rau, David W Dodick, Edita Navratilova, Frank Porreca
Migraine and sleep disorders are common co-morbidities. Patients frequently link their sleep to migraine attacks suggesting a potential causal relationship between these conditions. However, whether migraine pain promotes or disrupts sleep or whether sleep disruption can increase the risk of migraine remains unknown. We assessed the potential impact of periorbital allodynia, a measure consistent with migraine-like pain, from multiple preclinical models on sleep quantity and quality. Additionally, we evaluated the possible consequences of sleep deprivation in promoting susceptibility to migraine-like pain...
2024: Brain communications
https://read.qxmd.com/read/38443627/overnight-neuronal-plasticity-and-adaptation-to-emotional-distress
#5
REVIEW
Yesenia Cabrera, Karin J Koymans, Gina R Poe, Helmut W Kessels, Eus J W Van Someren, Rick Wassing
Expressions such as 'sleep on it' refer to the resolution of distressing experiences across a night of sound sleep. Sleep is an active state during which the brain reorganizes the synaptic connections that form memories. This Perspective proposes a model of how sleep modifies emotional memory traces. Sleep-dependent reorganization occurs through neurophysiological events in neurochemical contexts that determine the fates of synapses to grow, to survive or to be pruned. We discuss how low levels of acetylcholine during non-rapid eye movement sleep and low levels of noradrenaline during rapid eye movement sleep provide a unique window of opportunity for plasticity in neuronal representations of emotional memories that resolves the associated distress...
March 5, 2024: Nature Reviews. Neuroscience
https://read.qxmd.com/read/38443007/myotonic-dystrophy-type-1-dm1-clinical-characteristics-and-disease-progression-in-a-large-cohort
#6
JOURNAL ARTICLE
Tanushree Chawla, Nishanth Reddy, Rahul Jankar, Seena Vengalil, Kiran Polavarapu, Gautham Arunachal, Veeramani Preethish-Kumar, Saraswati Nashi, Mainak Bardhan, Jamuna Rajeshwaran, Mohammad Afsar, Manjusha Warrier, Priya T Thomas, Kandavel Thennarasu, Atchayaram Nalini
BACKGROUND: DM1 is a multisystem disorder caused by expansion of a CTG triplet repeat in the 3' non-coding region of DMPK. Neuropsychological consequences and sleep abnormalities are important associations in DM1. OBJECTIVE: To describe the clinical phenotype, disease progression and characterize the sleep alterations and cognitive abnormalities in a sub-set of patients. MATERIALS AND METHODS: A retrospective study on 120 genetically confirmed DM1 cases...
January 1, 2024: Neurology India
https://read.qxmd.com/read/38409939/biomarkers-of-neurodegeneration-in-isolated-and-antidepressant-related-rapid-eye-movement-sleep-behavior-disorder
#7
JOURNAL ARTICLE
Francesco Biscarini, Fabio Pizza, Stefano Vandi, Alex Incensi, Elena Antelmi, Vincenzo Donadio, Raffaele Ferri, Rocco Liguori, Giuseppe Plazzi
BACKGROUND AND PURPOSE: This study compared the features of isolated rapid eye movement (REM) sleep behavior disorder (iRBD) and antidepressant-related REM sleep behaviour disorder (RBD) with the aim of highlighting markers that might distinguish the two entities. METHODS: The observational cohort study included RBD patients with and without antidepressant use (antiD+ and antiD- patients, respectively), without cognitive impairment and parkinsonism. Clinical features of RBD, subtle motor and non-motor symptoms of parkinsonism, sleep architecture, REM atonia index, dopamine transporter-single photon emission computed tomography (DAT-SPECT) and skin biopsies for the intraneuronal alpha-synuclein (α-syn), were evaluated in the baseline work-up...
February 26, 2024: European Journal of Neurology
https://read.qxmd.com/read/38385964/alterations-in-the-multilayer-network-in-patients-with-rapid-eye-movement-sleep-behaviour-disorder
#8
JOURNAL ARTICLE
Dong Ah Lee, Won Hee Lee, Ho-Joon Lee, Kang Min Park
This study aimed to reveal the pathophysiology of isolated rapid eye movement sleep behaviour disorder (RBD) in patients using multilayer network analysis. Participants eligible for isolated RBD were included and verified via polysomnography. Both iRBD patients and healthy controls underwent brain MRI, including T1-weighted imaging and diffusion tensor imaging. Grey matter matrix was derived from T1-weighted images using a morphometric similarity network. White matter matrix was formed from diffusion tensor imaging-based structural connectivity...
February 22, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38365378/neurological-psychiatric-and-sleep-investigations-after-treatment-of-anti-leucine-rich-glioma-inactivated-protein-1-lgi1-encephalitis-in-spain-a-prospective-cohort-study
#9
JOURNAL ARTICLE
Amaia Muñoz-Lopetegi, Mar Guasp, Laia Prades, Eugenia Martínez-Hernández, Mireia Rosa-Justícia, Víctor Patricio, Thaís Armangué, Lorena Rami, Roger Borràs, Josefina Castro-Fornieles, Albert Compte, Carles Gaig, Joan Santamaria, Josep Dalmau
BACKGROUND: Anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis is an autoimmune disorder that can be treated with immunotherapy, but the symptoms that remain after treatment have not been well described. We aimed to characterise the clinical features of patients with anti-LGI1 encephalitis for 1 year starting within the first year after initial immunotherapy. METHODS: For this prospective cohort study, we recruited patients with anti-LGI1 encephalitis as soon as possible after they had received conventional immunotherapy for initial symptoms; patients were recruited from 21 hospitals in Spain...
March 2024: Lancet Neurology
https://read.qxmd.com/read/38353846/a-new-perspective-on-positive-symptoms-expression-of-damage-or-self-defence-mechanism-of-the-brain
#10
JOURNAL ARTICLE
Annibale Antonioni, Emanuela Maria Raho, Mariachiara Sensi, Francesco Di Lorenzo, Luciano Fadiga, Giacomo Koch
Usually, positive neurological symptoms are considered as the consequence of a mere, afinalistic and abnormal increase in function of specific brain areas. However, according to the Theory of Active Inference, which argues that action and perception constitute a loop that updates expectations according to a Bayesian model, the brain is rather an explorer that formulates hypotheses and tests them to assess the correspondence between internal models and reality. Moreover, the cerebral cortex is characterised by a continuous "conflict" between different brain areas, which constantly attempt to expand in order to acquire more of the limited available computational resources, by means of their dopamine-induced neuroplasticity...
February 14, 2024: Neurological Sciences
https://read.qxmd.com/read/38313757/masseter-vestibular-evoked-myogenic-potentials-a-new-tool-to-assess-the-vestibulomasseteric-reflex-pathway
#11
REVIEW
Aishwarya Nagarajan, Sujeet Kumar Sinha
PURPOSE: This review article provides the readers with an in-depth insight in understanding and interpreting various research literatures on the masseter vestibular evoked myogenic potentials (mVEMP). The article also reviews the contemporary researches involving the clinical applications of the mVEMP. CONCLUSIONS: Masseter VEMP is an evolving yet clinically promising neuro-otology test tool that has recently gained more research interest and is considered an additional tool to diagnose various vestibular disorders...
January 2024: Journal of Otology
https://read.qxmd.com/read/38287722/acute-rem-sleep-behaviour-disorder-associated-with-alcohol-withdrawal-a-case-report-and-literature-review
#12
Radhika Chakraborty, Tathagata Biswas, Biswa Ranjan Mishra, Arpit Parmar
INTRODUCTION: Rapid eye movement (REM) sleep behaviour disorder (RBD) is a parasomnia characterised by the loss of REM sleep muscle atonia and the enactment of dreams. Acute RBD associated with alcohol withdrawal syndrome is known, but the studies are limited, particularly on its neurobiological underpinnings and management alongside the withdrawal state. This work attempts to address this using a case study and relevant literature review. CASE PRESENTATION: A 40-year-old male with alcohol dependence (for 20 years) reported new-onset terrifying nightmares and violent behaviours in his sleep precipitated by alcohol withdrawal states for the last 18 months...
January 29, 2024: Drug and Alcohol Review
https://read.qxmd.com/read/38249652/impact-of-rem-sleep-behavior-and-sleep-talking-on-mortality-in-parkinson-s-disease
#13
JOURNAL ARTICLE
Eemil Partinen, Ari Ylikoski, Mariusz Sieminski, Markku Partinen
Background REM sleep behavior disorder (RBD) is a prodromal marker for Parkinson's disease (PD) and other alpha-synucleinopathies. Sleep talking (ST) is an isolated symptom and is frequent in PD and RBD. Here, we investigate the associations of ST and RBD with the mortality of PD patients. Patients and methods A total of 1,500 PD patients were randomly selected from the registry of the Finnish Parkinson's Association. Of the 855 that participated at baseline, 645 gave permission for follow-up studies. We gathered a completely filled sleep questionnaire and mortality information from 384 subjects...
January 2024: Curēus
https://read.qxmd.com/read/38227270/a-systematic-review-of-the-spectrum-and-prevalence-of-non-motor-symptoms-in-multiple-system-atrophy
#14
REVIEW
Chulika Makawita, Piriyankan Ananthavarathan, Rajith de Silva, Naveed Malek
BACKGROUND: Patients with Multiple System Atrophy (MSA) frequently report non-motor symptoms, and several research groups have highlighted this. OBJECTIVE: We systematically searched for and reviewed papers assessing prevalence of non-motor symptoms (NMS) in MSA patients as reported in the scientific literature. METHODS: We performed a systematic review of studies of subjects with MSA (involving > 10 patients) who were assessed for NMS, published in the English literature in PUBMED and EMBASE databases from 1947-2022...
January 16, 2024: Cerebellum
https://read.qxmd.com/read/38223295/knowledge-structure-and-emerging-trends-of-mild-cognitive-impairment-with-dyssomnias-in-recent-20-years-a-bibliometric-analysis-via-citespace-and-vosviewer
#15
REVIEW
Haoyu Huang, Zesen Zhuang, Yiwen Wan, Jiao Shi, Xu Yuan, Dan Wang, Shangjie Chen
BACKGROUND: Mild cognitive impairment (MCI), an intermediate stage between normal aging and dementia, has emerged as a prominent research area in geriatric care due to its heightened propensity for progressing toward dementia. Sleep plays a pivotal role in cognitive function, with dyssomnias not only exacerbating cognitive and affective symptoms associated with neurodegenerative diseases but also contributing to disease progression. AIM: This bibliometric analysis investigates the global research on MCI with dyssomnias over the past two decades, aiming to discern key findings, research domains, and emerging trends in this field...
2024: Behavioural Neurology
https://read.qxmd.com/read/38092812/mendelian-randomization-reveals-association-between-retinal-thickness-and-non-motor-symptoms-of-parkinson-s-disease
#16
JOURNAL ARTICLE
Hang Zhou, Bibiao Shen, Zifeng Huang, Shuzhen Zhu, Wanlin Yang, Fen Xie, Yuqi Luo, Feilan Yuan, Zhaohua Zhu, Chao Deng, Wenhua Zheng, Chengwu Yang, Chin-Hsien Lin, Bin Xiao, Eng-King Tan, Qing Wang
Retinal thickness is related to Parkinson's disease (PD), but its association with the severity of PD is still unclear. We conducted a Mendelian randomized (MR) study to explore the association between retinal thickness and PD. For the two-sample MR analysis, the summary statistics obtained from genome-wide association studies on the thickness of Retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) were employed as exposure, while the summary statistics associated with PD were used as the outcome...
December 13, 2023: NPJ Parkinson's Disease
https://read.qxmd.com/read/38069589/temporal-dynamics-of-awakenings-from-slow-wave-sleep-in-non-rapid-eye-movement-parasomnia
#17
JOURNAL ARTICLE
Iris A M Huijben, Ruud J G van Sloun, Bertram Hoondert, Sylvie Dujardin, Angelique Pijpers, Sebastiaan Overeem, Merel M van Gilst
Non-rapid eye movement parasomnia disorders, also called disorders of arousal, are characterized by abnormal nocturnal behaviours, such as confusional arousals or sleep walking. Their pathophysiology is not yet fully understood, and objective diagnostic criteria are lacking. It is known, however, that behavioural episodes occur mostly in the beginning of the night, after an increase in slow-wave activity during slow-wave sleep. A better understanding of the prospect of such episodes may lead to new insights in the underlying mechanisms and eventually facilitate objective diagnosis...
December 9, 2023: Journal of Sleep Research
https://read.qxmd.com/read/38014898/isolated-rapid-eye-movement-sleep-behaviour-disorder-irbd-in-the-island-study-linking-ageing-and-neurodegenerative-disease-island-sleep-study-protocol-and-baseline-characteristics
#18
JOURNAL ARTICLE
Samantha Bramich, Alastair J Noyce, Anna E King, Sharon L Naismith, Maneesh Varghese Kuruvilla, Simon J G Lewis, Eddy Roccati, Aidan D Bindoff, Kevin J Barnham, Leah C Beauchamp, James C Vickers, Laura Pérez-Carbonell, Jane Alty
Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is a sleep disorder that is characterised by dream enactment episodes during REM sleep. It is the strongest known predictor of α-synuclein-related neurodegenerative disease (αNDD), such that >80% of people with iRBD will eventually develop Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy in later life. More research is needed to understand the trajectory of phenoconversion to each αNDD. Only five 'gold standard' prevalence studies of iRBD in older adults have been undertaken previously, with estimates ranging from 0...
November 28, 2023: Journal of Sleep Research
https://read.qxmd.com/read/37978183/clinical-subtypes-in-patients-with-isolated-rem-sleep-behaviour-disorder
#19
JOURNAL ARTICLE
Aline Seger, Anja Ophey, Christopher E J Doppler, Johanna Kickartz, Marie-Sophie Lindner, Maximilian Hommelsen, Gereon R Fink, Michael Sommerauer
Patients with Parkinson's disease (PD) show a broad heterogeneity in clinical presentation, and subtypes may already arise in prodromal disease stages. Isolated REM sleep behaviour disorder (iRBD) is the most specific marker of prodromal PD, but data on clinical subtyping of patients with iRBD remain scarce. Therefore, this study aimed to identify iRBD subtypes. We conducted comprehensive clinical assessments in 66 patients with polysomnography-proven iRBD, including motor and non-motor evaluations, and applied a two-step cluster analysis...
November 17, 2023: NPJ Parkinson's Disease
https://read.qxmd.com/read/37975761/the-effects-of-rivastigmine-on-neuropsychiatric-symptoms-in-the-early-stages-of-parkinson-s-disease-a-systematic-review
#20
REVIEW
Siobhan Reilly, Simran Dhaliwal, Usman Arshad, Antonella Macerollo, Nusrat Husain, Antonio Da Costa
BACKGROUND AND PURPOSE: Neuropsychiatric symptoms including depression, apathy and psychosis occur frequently in patients with Parkinson's disease. A subgroup of patients develop cognitive impairment, which may increase the risk of falls due to reduced attention. The acetylcholinesterase inhibitor rivastigmine is beneficial in Parkinson's disease dementia, but whether the use of rivastigmine is effective earlier in the disease course is unclear. The aim of this systematic review was to assess the evidence for rivastigmine in the treatment of neuropsychiatric symptoms in Parkinson's disease without dementia...
November 17, 2023: European Journal of Neurology
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