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Neonatal Seizures

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https://www.readbyqxmd.com/read/29906699/causes-of-mortality-in-early-infantile-epileptic-encephalopathy-a-systematic-review
#1
REVIEW
Graciane Radaelli, Francisco de Souza Santos, Wyllians Vendramini Borelli, Leonardo Pisani, Magda Lahorgue Nunes, Fulvio Alexandre Scorza, Jaderson Costa da Costa
INTRODUCTION: Early infantile epileptic encephalopathy syndrome (EIEE), also known as Ohtahara syndrome, is an age-dependent epileptic encephalopathy syndrome defined by clinical features and electroencephalographic findings. Epileptic disorders with refractory seizures beginning in the neonatal period and/or early infancy have a potential risk of premature mortality, including sudden death. We aimed to identify the causes of death in EIEE and conducted a literature survey of fatal outcomes...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29906696/ictal-signs-in-tuberous-sclerosis-complex-clinical-and-video-eeg-features-in-a-large-series-of-recorded-seizures
#2
Miriam Nella Savini, Alessia Mingarelli, Aglaia Vignoli, Francesca La Briola, Valentina Chiesa, Angela Peron, Roberto Mai, Laura Tassi, Massimo Mastrangelo, Elena Zambrelli, Katherine Turner, Maria Paola Canevini
Epilepsy is the most common neurological symptom in tuberous sclerosis complex (TSC), occurring in 72-85% of affected individuals. Despite the large number of patients reported, their electroclinical phenotype has been rarely described. We analyzed seizure semiology through ictal video-electroencephalography (V-EEG) recordings in a large series of patients. In this multicenter study, we reviewed V-EEGs of 51 patients: ictal recordings were analyzed in correlation with their clinical variables. The median age of epilepsy onset was six months (one day-16 years), with onset in the first year of life in 71% patients (36/51), in 10 of them during the neonatal period...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29903834/topiramate-for-seizures-in-preterm-infants-and-the-development-of-necrotizing-enterocolitis
#3
Benjamin Courchia, Waleed Kurtom, Alyssa Pensirikul, Teresa Del-Moral, Maria Buch
Neonatal seizures represent a significant health burden on the term and preterm neonatal population and are linked to poor long-term neurodevelopmental outcomes. Currently, there are no US Food and Drug Administration-approved antiepileptic drugs for neonates, and authors of the medical literature have yet to reach a consensus on the most adequate approach to neonatal seizures. Topiramate is readily used in the adult and older pediatric population for the management of migraines and partial-onset seizures. Topiramate continues to gain favor among pediatric neurologists who often recommend this medication as a third-line treatment of neonatal seizures...
June 14, 2018: Pediatrics
https://www.readbyqxmd.com/read/29903435/cerebellar-networks-and-neuropathology-of-cerebellar-developmental-disorders
#4
Harvey B Sarnat
The cerebellar system is a series of axonal projections and synaptic circuits as networks, similar to those of the limbic system and those subserving the propagation and spread of seizures. Three principal cerebellar networks are identified and cerebellar disease often affects components of the networks other than just the cerebellar cortex. Contemporary developmental neuropathology of the cerebellum is best considered in the context of alterations of developmental processes: embryonic segmentation and genetic gradients along the three axes of the neural tube, individual neuronal and glial cell differentiation, migration, synaptogenesis, and myelination...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29895836/predictive-value-of-early-eeg-for-seizures-in-neonates-with-hypoxic-ischemic-encephalopathy-undergoing-therapeutic-hypothermia
#5
Marie-Coralie Cornet, Archana Pasupuleti, Annie Fang, Fernando Gonzalez, Thomas Shimotake, Donna Marie Ferriero, Hannah Cranley Glass, Maria Roberta Cilio
OBJECTIVES: To assess the prognostic significance of an early normal/mildly abnormal conventional EEG (cEEG) on seizure risk in neonates undergoing therapeutic hypothermia. METHODS: We reviewed the video-EEG recordings from a large cohort of neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy from 2008 to 2017 in a single tertiary center. Continuous video-EEG was started as soon as possible (median 8.2 h) and continued throughout hypothermia and rewarming...
May 3, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29893939/experience-of-perinatal-and-neonatal-chikungunya-virus-chikv-infection-in-a-tertiary-care-neonatal-centre-during-outbreak-in-north-india-in-2016-a-case-series
#6
Surender Kumar, Gopal Agrawal, Sanjay Wazir, Anil Kumar, Sandeep Dubey, Manish Balde, Bir Singh Yadav
Background: In 2016, there was a massive outbreak of chikungunya in North India. During the epidemic, we observed many neonatal and early infantile cases of chikungunya, with a probable perinatal transmission. Methods: This retrospective study was carried out in a tertiary care neonatal centre between August 2016 and November 2016. Chikungunya virus (CHIKV) infection was detected and confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and/or serology (anti-CHIKV IgM) in mothers and infants...
June 9, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29889725/introduction-of-continuous-video-eeg-monitoring-into-2-different-nicu-models-by-training-neonatal-nurses
#7
Ipsita Goswami, Luis Bello-Espinosa, Jeffrey Buchhalter, Harish Amin, Alexandra Howlett, Michael Esser, Sumesh Thomas, Cathy Metcalfe, Jan Lind, Norma Oliver, Silvia Kozlik, Khorshid Mohammad
BACKGROUND: Continuous video electroencephalographic (EEG) (cvEEG) monitoring is emerging as the standard of care for diagnosis and management of neonatal seizures. However, cvEEG is labor-intensive and the need to initiate and interpret studies on a 24-hour basis is a major limitation. PURPOSE: This study aims at establishing consistency in monitoring of newborns admitted to 2 different neonatal intensive care units (NICUs) managed by the same neurocritical care team...
June 8, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29886041/outcomes-after-acute-symptomatic-seizures-in-children-admitted-to-a-neonatal-neurocritical-care-service
#8
Hannah C Glass, Adam L Numis, Dawn Gano, Varun Bali, Elizabeth E Rogers
BACKGROUND: Neonatal seizures due to acute brain injury are associated with high rates of death, disability, and epilepsy. Our objective was to examine incidence of and risk factors for epilepsy among survivors of acute symptomatic neonatal seizures who were cared for by a neonatal neurocritical care service. METHODS: Neonates with acute symptomatic seizures who were admitted to UCSF Benioff Children's Hospital Neuro-Intensive Care Nursery from July 2008 to June 2014 were considered for inclusion...
April 20, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29884333/prominent-t-wave-and-st-segment-elevation-on-electrocardiogram-during-neonatal-seizure
#9
Tomomasa Terada, Kazuhiro Mori, Miki Inoue, Miki Shono, Yoshihiro Toda
No abstract text is available yet for this article.
May 25, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29878631/midazolam-as-a-first-line-treatment-for-neonatal-seizures-retrospective-study
#10
Kim Dao, Eric Giannoni, Manuel Diezi, Eliane Roulet-Perez, Sebastien Lebon
Midazolam is commonly used to treat refractory seizures in newborns and as a first-line anti-epileptic drug in children. Its use as first-line treatment of neonatal seizures has not been investigated so far. We retrospectively studied the tolerability of midazolam in 72 newborn infants who received i.v. or i.n. midazolam as first-line treatment for seizures. No major side-effect exclusively due to midazolam was reported. The i.n. route was used for 20 patients (27.8%). Effectiveness could not be formally evaluated due to the absence of systematic electroencephalogram recording while midazolam was administered...
May 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29875203/acute-and-chronic-neurological-consequences-of-early-life-zika-virus-infection-in-mice
#11
Isis Nem de Oliveira Souza, Paula S Frost, Julia V França, Jéssica B Nascimento-Viana, Rômulo L S Neris, Leandro Freitas, Daniel J L L Pinheiro, Clara O Nogueira, Gilda Neves, Leila Chimelli, Fernanda G De Felice, Ésper A Cavalheiro, Sergio T Ferreira, Iranaia Assunção-Miranda, Claudia P Figueiredo, Andrea T Da Poian, Julia R Clarke
Although congenital Zika virus (ZIKV) exposure has been associated with microcephaly and other neurodevelopmental disorders, long-term consequences of perinatal infection are largely unknown. We evaluated short- and long-term neuropathological and behavioral consequences of neonatal ZIKV infection in mice. ZIKV showed brain tropism, causing postnatal-onset microcephaly and several behavioral deficits in adulthood. During the acute phase of infection, mice developed frequent seizures, which were reduced by tumor necrosis factor-α (TNF-α) inhibition...
June 6, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29873961/valproate-in-pregnancy-recent-research-and-regulatory-responses
#12
Chittaranjan Andrade
Valproate and formulations thereof are approved for the management of seizure disorders, bipolar disorder, and migraine. Valproate is also used for many off-label indications. Unfortunately, data from observational studies indicate that valproate is perhaps the most teratogenic drug in the neuropsychiatric pharmacopeia. It is significantly more teratogenic than many other antiepileptic drugs (AEDs). In observational studies, gestational exposure to valproate is also associated with higher risks of cognitive, language, and psychomotor delay during early childhood and possibly with an increased risk of autism, as well...
May 29, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29871901/increased-detection-of-human-parechovirus-infection-in-infants-in-england-during-2016-epidemiology-and-clinical-characteristics
#13
Laura Ferreras Antolín, Seilesh Kadambari, Serena Braccio, Julian Wei-Tze Tang, Jacqueline Xerry, David James Allen, Shamez N Ladhani
BACKGROUND: Human parechovirus (HPeV), like enteroviruses, usually causes mild self-limiting respiratory and gastrointestinal symptoms. In infants, HPeV can occasionally cause serious illnesses, including sepsis-like syndrome and encephalitis. In summer 2016, Public Health England (PHE) received increasing reports of severe HPeV infections nationally. We, therefore, reviewed all infants with confirmed HPeV across England during 2016. METHODS: HPeV cases in infants aged <12 months reported to PHE during 2016 were followed up using a clinical questionnaire...
June 5, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29861333/what-is-new-talk-about-status-epilepticus-in-the-neonatal-period
#14
REVIEW
Francesco Pisani, Elena Pavlidis
Nowadays, no general consensus was achieved regarding neonatal status epilepticus and its definition. Indeed, different criteria (mainly based on seizure duration) were used. Whereas a recent proposal has been developed to define status epilepticus in older ages, it seems that the peculiar characteristics of neonatal seizures and of the immature brain make difficult to find a tailored definition for this period of life. Achieving a consensus on this entity would mean to make the first step toward a targeted therapeutic strategy of intervention...
May 24, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29852413/diagnostic-yield-of-targeted-massively-parallel-sequencing-in-children-with-epileptic-encephalopathy
#15
Kavitha Kothur, Katherine Holman, Elizabeth Farnsworth, Gladys Ho, Michelle Lorentzos, Christopher Troedson, Sachin Gupta, Richard Webster, Peter G Procopis, Manoj P Menezes, Jayne Antony, Simone Ardern-Holmes, Russell C Dale, John Christodoulou, Deepak Gill, Bruce Bennetts
PURPOSE: To report our institutional experience of targeted massively parallel sequencing (MPS) testing in children with epilepsy. METHOD: We retrospectively analysed the yield of targeted epileptic encephalopathy (EE) panel of 71 known EE genes in patients with epilepsy of unknown cause, who underwent clinical triage by a group of neurologists prior to the testing. We compared cost of the EE panel approach compared to traditional evaluation in patients with identified pathogenic variants...
May 28, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29844767/neonatal-seizures-is-the-remedy-worse-than-the-disease
#16
COMMENT
Laura A Jansen
No abstract text is available yet for this article.
January 2018: Epilepsy Currents
https://www.readbyqxmd.com/read/29844171/dynamic-action-potential-clamp-predicts-functional-separation-in-mild-familial-and-severe-de-novo-forms-of-scn2a-epilepsy
#17
Géza Berecki, Katherine B Howell, Yadeesha H Deerasooriya, Maria Roberta Cilio, Megan K Oliva, David Kaplan, Ingrid E Scheffer, Samuel F Berkovic, Steven Petrou
De novo variants in SCN2A developmental and epileptic encephalopathy (DEE) show distinctive genotype-phenotype correlations. The two most recurrent SCN2A variants in DEE, R1882Q and R853Q, are associated with different ages and seizure types at onset. R1882Q presents on day 1 of life with focal seizures, while infantile spasms is the dominant seizure type seen in R853Q cases, presenting at a median age of 8 months. Voltage clamp, which characterizes the functional properties of ion channels, predicted gain-of-function for R1882Q and loss-of-function for R853Q...
May 29, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29843267/impact-of-a-neuro-intensive-care-service-for-newborns
#18
M J Harbert, R Sey, K Arnell, L Salinda, M K Brown, D Lazarus, D M Poeltler, P R Wozniak, M R Rasmussen
BACKGROUND: Advances in treating the injured neonatal brain have given rise to neuro-intensive care services for newborns. This study assessed the impact of one such service in a cohort of newborns treated with therapeutic hypothermia. METHODS: Our newborn neuro-intensive care service was started in November 2012. From January 2008 to October 2016, a cohort of 158 newborns was treated with therapeutic hypothermia, 29 before and 129 after the inception of the service...
May 23, 2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29803998/conventional-mri-scan-and-dti-imaging-show-more-severe-brain-injury-in-neonates-with-hypoxic-ischemic-encephalopathy-and-seizures
#19
Beth M Kline-Fath, Paul S Horn, Weihong Yuan, Stephanie Merhar, Charu Venkatesan, Cameron W Thomas, Mark B Schapiro
BACKGROUND: Neonates with hypoxic-ischemic encephalopathy (HIE) and seizures have poorer outcome for undetermined reasons. AIMS: Our aim was to determine if brain imaging was more abnormal in neonates with HIE and electrographically confirmed seizures and whether this was impacted by seizure burden. STUDY DESIGN: Single center retrospective review. SUBJECTS: Forty-eight term neonates with HIE (with and without seizures) underwent MRI brain scans before age 14 days between the years 2008 and 2013...
May 23, 2018: Early Human Development
https://www.readbyqxmd.com/read/29801191/neonatal-alexander-disease-novel-gfap-mutation-and-comparison-to-previously-published-cases
#20
Oula Knuutinen, Maria Kousi, Maria Suo-Palosaari, Jukka S Moilanen, Hannu Tuominen, Leena Vainionpää, Tarja Joensuu, Anna-Kaisa Anttonen, Johanna Uusimaa, Anna-Elina Lehesjoki, Päivi Vieira
Alexander disease (AxD) is a genetic leukodystrophy caused by GFAP mutations leading to astrocyte dysfunction. Neonatal AxD is a rare phenotype with onset in the first month of life. The proband, belonging to a large pedigree with dominantly inherited benign familial neonatal epilepsy (BFNE), had a phenotype distinct from the rest of the family, with hypotonia and macrocephaly in addition to drug-resistant neonatal seizures. The patient deteriorated and passed away at 6 weeks of age. The pathological and neuroimaging data were consistent with the diagnosis of AxD...
May 25, 2018: Neuropediatrics
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