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Alper Ağca, Ahmet Demirok, Yusuf Yıldırım, Ali Demircan, Dilek Yaşa, Ceren Yeşilkaya, İrfan Perente, Muhittin Taşkapılı
Small-incision lenticule extraction (SMILE) is an alternative to laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) for the correction of myopia and myopic astigmatism. SMILE can be performed for the treatment of myopia ≤-12 D and astigmatism ≤5 D. The technology is currently only available in the VisuMax femtosecond laser platform. It offers several advantages over LASIK and PRK; however, hyperopia treatment, topography-guided treatment, and cyclotorsion control are not available in the current platform...
2016: Clinical Ophthalmology
Tong Shu Li, Àlex Bravo, Laura I Furlong, Benjamin M Good, Andrew I Su
Relations between chemicals and diseases are one of the most queried biomedical interactions. Although expert manual curation is the standard method for extracting these relations from the literature, it is expensive and impractical to apply to large numbers of documents, and therefore alternative methods are required. We describe here a crowdsourcing workflow for extracting chemical-induced disease relations from free text as part of the BioCreative V Chemical Disease Relation challenge. Five non-expert workers on the CrowdFlower platform were shown each potential chemical-induced disease relation highlighted in the original source text and asked to make binary judgments about whether the text supported the relation...
2016: Database: the Journal of Biological Databases and Curation
Walter Sekundo, Dan Z Reinstein, Marcus Blum
The aim of this study is to establish and to prove a new lenticule shape for the treatment of hyperopia using a 500 kHz femtosecond laser and the femtosecond lenticule extraction (ReLEx FLEx) technique. Improved lenticule shapes with a large transition zone of at least 2 mm adjusted to the 5.75 mm optical zone were designed. A prospective pilot study on nine eyes of five patients who underwent an uncomplicated FLEx using VisuMax femtosecond laser (Carl Zeiss Meditec AG) for spherical hyperopia was performed...
May 2016: Lasers in Medical Science
Vipul Bhandari, Sri Ganesh, Sheetal Brar, Rahul Pandey
PURPOSE: To report the initial clinical outcomes of the small incision lenticule extraction (SMILE)-derived glued lenticule patch graft for management of microperforations and complicated corneal tears. METHODS: In this single-center case series, 7 eyes (of 7 patients) that presented with microperforations, partial-thickness corneal defect, and traumatic complicated corneal tear were repaired with a lenticule patch graft obtained from Refractive Lenticule Extraction (ReLEx) with the SMILE procedure...
March 2016: Cornea
Marcus Blum, Kathrin Täubig, Christin Gruhn, Walter Sekundo, Kathleen S Kunert
BACKGROUND: To evaluate the 5-year results of Refractive Lenticule Extraction (ReLEx) as Small Incision Lenticule Extraction (SMILE) technique for treatment of myopia and myopic astigmatism. METHODS: In 2008/2009, the worldwide first 91 eyes were treated using a novel surgical technique (SMILE), where a refractive lenticule of intrastromal corneal tissue is removed though a small incision completely eliminating flap-cutting. 56 out of 91 eyes of the original treatment group volunteered for re-examination 5 years after surgery...
September 2016: British Journal of Ophthalmology
T Kohnen, M Remy
Techniques available for corneal lamellar refractive surgery are laser-assisted in situ keratomileusis (LASIK) using a microkeratome or femtosecond laser incision followed by excimer laser corneal ablation, and femtosecond laser-assisted refractive lenticule extraction (ReLEx). These treatments are nowadays considered to be safe and effective standard procedures for surgical correction of mild to moderate ametropia. Possible complications include too small or decentered optical zones, intraoperative flap cutting errors and postoperative inflammation (e...
December 2015: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Sri Ganesh, Utsav Patel, Sheetal Brar
PURPOSE: To compare the posterior corneal curvature changes, in terms of corneal power and asphercity, following Refractive Small Incision Lenticule Extraction (ReLEx SMILE) procedure for low, moderate, and high myopia. METHODS: This retrospective, non randomized, comparative, interventional trial; included 52 eyes of 26 patients, divided in three groups: low myopia (myopia ≤3 D [diopters] spherical equivalent [SE]), moderate myopia (myopia >3 D and <6 D SE), and high myopia (myopia ≥6 D SE)...
2015: Clinical Ophthalmology
Arturo Ramirez-Miranda, Tito Ramirez-Luquin, Alejandro Navas, Enrique O Graue-Hernandez
PURPOSE: To report the complications associated with refractive lenticule extraction (ReLEx) in its 2 modalities: femtosecond lenticule extraction (FLEx) and small incision lenticule extraction (SMILE). METHODS: In this retrospective review of a consecutive clinical case series, all patients who had a complicated ReLex FLEx or ReLEx SMILE procedure at the Cornea and External Disease Department at the Instituto de Oftalmologia Fundacion Conde de Valenciana, Mexico City, Mexico, were included...
October 2015: Cornea
Sri Ganesh, Sheetal Brar
Purpose. To study the safety and clinical outcomes of ReLEx SMILE with accelerated cross-linking in individuals with thinner corneas, borderline topography, and higher refractive errors. Methods. Eligible patients first underwent SMILE procedure for correction of myopic refractive error. Following the removal of lenticule, 0.25% riboflavin in saline was injected into the interface and allowed to diffuse for 60 seconds. Finally, eye was exposed to UV-A radiation of 45 mW/cm(2) for 75 seconds through the cap...
2015: Journal of Ophthalmology
Kazutaka Kamiya, Kimiya Shimizu, Mayumi Yamagishi, Akihito Igarashi, Hidenaga Kobashi
Purpose. To assess the amount and the axis orientation of anterior and posterior corneal astigmatism after refractive lenticule extraction (ReLEx) for myopic astigmatism. Methods. We retrospectively examined 53 eyes of 53 consecutive patients (mean age ± standard deviation, 33.2 ± 6.5 years) undergoing ReLEx to correct myopic astigmatism (manifest cylinder = 0.5 diopters (D)). Power vector analysis was performed with anterior and posterior corneal astigmatism measured with a rotating Scheimpflug system (Pentacam HR, Oculus) and refractive astigmatism preoperatively and 3 months postoperatively...
2015: Journal of Ophthalmology
C Albou-Ganem, A Lavaud, R Amar
PURPOSE: It is currently possible to obtain refractive correction without using an excimer laser; the technique is called ReLEx(®) (Refractive Lenticule extraction) and uses the femtosecond laser VisuMax(®) (Carl Zeiss Meditec, Jena, Germany). We present initial clinical experience with small-incision (4mm) lenticule extraction (SMILE) for the treatment of moderate to high myopia via a retrospective study of 106 myopic and astigmatic eyes. MATERIALS AND METHODS: This retrospective study of 106 eyes measures postoperative visual acuity to determine the safety, efficacy and predictability of the technique...
March 2015: Journal Français D'ophtalmologie
Chee Wai Wong, Cordelia Chan, Donald Tan, Jodhbir S Mehta
PURPOSE: To describe the incidence, management, and outcomes of suction loss in refractive lenticule extraction (ReLEx). SETTING: Tertiary eye hospital. DESIGN: Retrospective case series. METHOD: All patients who experienced suction loss during refractive lenticule extraction from March 9, 2010, to August 5, 2013, were evaluated preoperatively, including slitlamp biomicroscopy, fundoscopy, corneal topography, ultrasound pachymetry, manifest and cycloplegic refractions, and measurement of uncorrected (UDVA) and corrected (CDVA) distance visual acuities...
December 2014: Journal of Cataract and Refractive Surgery
Sri Ganesh, Sheetal Brar, Pallavi A Rao
PURPOSE: To describe the technique of cryopreservation of corneal lenticules extracted after small incision refractive lenticule extraction (ReLEx SMILE) and initial results of femtosecond laser intrastromal lenticular implantation for hyperopia. METHODS: Lenticules were collected from patients undergoing ReLEx SMILE for the correction of myopia and subjected to a tissue processing technique and cryopreservation. These lenticules were subsequently used to treat 8 hyperopic eyes and 1 aphakic eye...
December 2014: Cornea
Shaohui Gao, Saiqun Li, Liangping Liu, Yong Wang, Hui Ding, Lili Li, Xingwu Zhong
PURPOSE: To characterize the early ocular-surface changes or tear inflammatory-mediators levels following small-incision lenticule extraction (ReLEx smile) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK). METHODS: Forty-seven myopic subjects were recruited for this prospective study. Fifteen underwent ReLEx smile and thirty-two underwent FS-LASIK. Corneal fluorescein (FL) staining, tear break-up time (TBUT), Schirmer I test (SIT), ocular surface disease index (OSDI) and central corneal sensitivity were evaluated in all participants...
2014: PloS One
Marcus Blum, Andrea Flach, Kathleen S Kunert, Walter Sekundo
PURPOSE: To evaluate the 5-year results of femtosecond laser-assisted refractive lenticule extraction (ReLEx-FLEx) for the treatment of myopia and myopic astigmatism. SETTING: Departments of Ophthalmology, Helios Klinikum Erfurt, Erfurt, and Phillips Universität Marburg, Marburg, Germany. DESIGN: Prospective clinical trial. METHODS: This was a follow-up of a prospective study that evaluated the first patients treated with refractive lenticule extraction, in which a flap and a refractive lenticule of intrastromal corneal tissue were simultaneously cut using a 200 kHz Visumax femtosecond laser system...
September 2014: Journal of Cataract and Refractive Surgery
Marcus Ang, Jodhbir S Mehta, Cordelia Chan, Hla M Htoon, Jane C W Koh, Donald T Tan
PURPOSE: To describe the transition and outcomes of 3 refractive lenticule extraction (ReLEx) techniques: femtosecond lenticule extraction (FLEx), small-incision lenticule extraction (SMILE), and pseudo small-incision lenticule extraction. SETTING: Singapore National Eye Center, Singapore. DESIGN: Prospective comparative case series. METHODS: Refractive lenticule extraction was performed between March 1, 2010, and November 1, 2012, using the Visumax 500 kHz femtosecond laser system...
September 2014: Journal of Cataract and Refractive Surgery
T Lapp, C Auw-Hädrich, F Sadler, D Böhringer, M Blum, T Reinhard, J Heichel, K S Kunert
BACKGROUND: ReLEx®flex is a corneal refractive procedure performed by removing corneal lenticules with a femtosecond (fs) laser system. Using electron microscopy, tissue parameters of extracted lenticules were analysed for potential correlations to the refractive results. Furthermore, the effect of previous contact lens (CL) wear on refractive stability (regression) was tested. PATIENTS AND METHODS: 19 lenticules from 11 patients (age 24-56 years, 8 f, 3 m) were prepared for EM...
July 2014: Klinische Monatsblätter Für Augenheilkunde
Iben Bach Pedersen, Sashia Bak-Nielsen, Anders Højslet Vestergaard, Anders Ivarsen, Jesper Hjortdal
PURPOSE: To evaluate corneal biomechanical properties after LASIK, ReLEx flex, and the flap-free procedure ReLEx smile by Scheimpflug-based dynamic tonometry (Corvis ST) and non-contact differential tonometry (Ocular Response Analyzer, ORA). METHODS: Patients treated for high myopia (-10.5 to -5.5 diopters, spherical equivalent refraction) more than one year previously at Aarhus University Hospital were included. Treatments comprised LASIK (35 eyes), ReLEx flex (31 eyes), and ReLEx smile (29 eyes)...
August 2014: Graefe's Archive for Clinical and Experimental Ophthalmology
Walter Sekundo, Jana Gertnere, Thomas Bertelmann, Igor Solomatin
BACKGROUND: To report one year results of the first cohort of routine refractive lenticule extraction through a small incision (ReLEx SMILE) for correction of myopia and myopic astigmatism. METHODS: Fifty-four eyes of 27 patients with spherical equivalent of -4.68 ± 1.29D who underwent routine ReLEx SMILE by a single surgeon were prospectively followed-up for 1 year. We used the VisuMax femtosecond laser system (Carl Zeiss Meditec AG, Germany) with a 500 kHz repetition rate...
May 2014: Graefe's Archive for Clinical and Experimental Ophthalmology
Anders Højslet Vestergaard
UNLABELLED: Surgical correction of refractive errors is becoming increasingly popular. In the 1990s, the excimer laser revolutionized the field of corneal refractive surgery with PRK and LASIK, and lately refractive lenticule extraction (ReLEx) of intracorneal tissue, using only a femtosecond laser, has become possible. Two new procedures were developed, ReLEx flex (FLEX) and ReLEx smile (SMILE). Until this thesis, only a few long-term studies of PRK with a relatively limited number of patients had been published; therefore, this thesis intended to retrospectively evaluate long-term outcomes after PRK for all degrees of myopia for a large number of patients...
March 2014: Acta Ophthalmologica
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