keyword
MENU ▼
Read by QxMD icon Read
search

paradoxical

keyword
https://www.readbyqxmd.com/read/29786883/left-ventricular-aneurysms-in-hypertrophic-cardiomyopathy-with-midventricular-obstruction-a-systematic-review-of-literature
#1
Moustafa O Elsheshtawy, Ahmed N Mahmoud, Mahmoud Abdelghany, Ida H Suen, Adnan Sadiq, Jacob Shani
BACKGROUND: Hypertrophic cardiomyopathy (HCM) with or without left ventricular apical aneurysm (LVA) had been studied in the past. Midventricular obstruction associated with HCM and LVA is a unique entity that has not been distinguished previously as a separate phenotypic disease in HCM patients. METHODS: A systematic review of Pubmed and Google Scholar was conducted from inception until September 2017 for all observational studies conducted on HCM with midventricular obstruction and LVA...
May 22, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29785777/paradoxical-effect-of-baclofen-on-social-behavior-in-the-fragile-x-syndrome-mouse-model
#2
Shimriet Zeidler, Andreea S Pop, Israa A Jaafar, Helen de Boer, Ronald A M Buijsen, Celine E F de Esch, Ingeborg Nieuwenhuizen-Bakker, Renate K Hukema, Rob Willemsen
INTRODUCTION: Fragile X syndrome (FXS) is a common monogenetic cause of intellectual disability, autism spectrum features, and a broad range of other psychiatric and medical problems. FXS is caused by the lack of the fragile X mental retardation protein (FMRP), a translational regulator of specific mRNAs at the postsynaptic compartment. The absence of FMRP leads to aberrant synaptic plasticity, which is believed to be caused by an imbalance in excitatory and inhibitory network functioning of the synapse...
April 26, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29784935/a-causal-mechanism-for-childhood-acute-lymphoblastic-leukaemia
#3
REVIEW
Mel Greaves
In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two discrete steps. First, in utero initiation by fusion gene formation or hyperdiploidy generates a covert, pre-leukaemic clone. Second, in a small fraction of these cases, the postnatal acquisition of secondary genetic changes (primarily V(D)J recombination-activating protein (RAG) and activation-induced cytidine deaminase (AID)-driven copy number alterations in the case of ETS translocation variant 6 (ETV6)-runt-related transcription factor 1 (RUNX1)+ ALL) drives conversion to overt leukaemia...
May 21, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29784730/association-of-anthropometric-measures-with-prostate-cancer-among-african-american-men-in-the-nci-maryland-prostate-cancer-case-control-study
#4
Margaret S Pichardo, Cheryl J Smith, Tiffany H Dorsey, Christopher A Loffredo, Stefan Ambs
BACKGROUND: Obesity is a cancer risk factor. While it does not increase the risk of localized prostate cancer, it raises the risk of the aggressive disease in men of European ancestry. Few studies investigated obesity as a prostate cancer risk factor in men of African ancestry. Findings from those studies were heterogeneous but some reported an association of excess body fatness with aggressive disease. METHODS: We examined the relationship of body mass index (BMI), waist circumference, and waist-hip ratio with prostate cancer in African-American and European-American men in the NCI-Maryland Prostate Cancer Case-Control study consisting of 798 men with incident prostate cancer (402 African-American and 496 European-American) and 1008 population-based controls (474 African-American and 534 European-American)...
May 21, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29784248/conventional-and-advanced-mri-in-multiple-sclerosis
#5
REVIEW
C Louapre
Magnetic resonance imaging (MRI) plays a central role in the management of patients with multiple sclerosis (MS). T2-weighted/FLAIR lesions have been included in the diagnostic criteria since 2001, and the importance of the technology has been expanded in each successive revision of the McDonald criteria. While the typical focal hyperintense lesions seen on T2 and FLAIR sequences in several areas of the central nervous system are key features for MS diagnosis, they can also be used to monitor disease activity, particularly in asymptomatic patients, and to evaluate therapeutic responses...
May 18, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29782996/reducing-waste-in-evaluation-studies-on-fall-risk-assessment-tools-for-older-people
#6
Gabriele Meyer, Ralph Möhler, Sascha Köpke
OBJECTIVE: To critically appraise the recognition of methodological challenges in evaluation studies on assessment tools and nurses' clinical judgement on fall risk in older people and suggest how to reduce respective research waste. STUDY DESIGN: Opinion paper and narrative review covering systematic reviews on studies assessing diagnostic accuracy and impact of assessment tools and/or nurses' clinical judgement. RESULTS: Eighteen reviews published in the last 15 years were analysed...
May 18, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29782991/beneficial-and-paradoxical-roles-of-selenium-at-nutritional-levels-of-intake-in-healthspan-and-longevity
#7
REVIEW
Li Zhang, Huawei Zeng, Wen-Hsing Cheng
Accumulation of genome and macromolecule damage is a hallmark of aging, age-associated degeneration, and genome instability syndromes. Although processes of aging are irreversible, they can be modulated by genome maintenance pathways and environmental factors such as diet. Selenium (Se) confers its physiological functions mainly through selenoproteins, but Se compounds and other proteins that incorporate Se nonspecifically also impact optimal health. Bruce Ames proposed that the aging process could be mitigated by a subset of low-hierarchy selenoproteins whose levels are preferentially reduced in response to Se deficiency...
May 18, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29781626/on-selecting-evidence-to-test-hypotheses-a-theory-of-selection-tasks
#8
Marco Ragni, Ilir Kola, Philip N Johnson-Laird
How individuals choose evidence to test hypotheses is a long-standing puzzle. According to an algorithmic theory that we present, it is based on dual processes: individuals' intuitions depending on mental models of the hypothesis yield selections of evidence matching instances of the hypothesis, but their deliberations yield selections of potential counterexamples to the hypothesis. The results of 228 experiments using Wason's selection task corroborated the theory's predictions. Participants made dependent choices of items of evidence: the selections in 99 experiments were significantly more redundant (using Shannon's measure) than those of 10,000 simulations of each experiment based on independent selections...
May 21, 2018: Psychological Bulletin
https://www.readbyqxmd.com/read/29781419/adherence-to-the-french-eating-model-is-inversely-associated-with-overweight-and-obesity-results-from-a-large-sample-of-french-adults
#9
Pauline Ducrot, Caroline Méjean, France Bellisle, Benjamin Allès, Serge Hercberg, Sandrine Péneau
The 'French Eating Model' characterised by structured meals and conviviality has received little attention, although it has been suggested as a potential explanation of the French paradox. This study aims at assessing the adherence to this model in French adults and whether it is associated with weight status. Eating behaviour and, in particular, number of meals per day, snacking frequency, meal time, meal duration, number of courses, position (standing, sitting), presence of others and pleasure experienced was assessed in 2014, in 47 219 participants of the NutriNet-Santé study...
May 21, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29780962/challenging-aspects-of-contemporary-cochlear-implant-electrode-array-design
#10
REVIEW
Pavel Mistrík, Claude Jolly, Daniel Sieber, Ingeborg Hochmair
Objective: A design comparison of current perimodiolar and lateral wall electrode arrays of the cochlear implant (CI) is provided. The focus is on functional features such as acoustic frequency coverage and tonotopic mapping, battery consumption and dynamic range. A traumacity of their insertion is also evaluated. Methods: Review of up-to-date literature. Results: Perimodiolar electrode arrays are positioned in the basal turn of the cochlea near the modiolus...
December 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29777952/the-opportunity-to-avoid-pain-may-paradoxically-increase-fear
#11
Christine M van Vliet, Ann Meulders, Linda M G Vancleef, Johan W S Vlaeyen
Fear-avoidance models propose that pain-related fear may spur avoidance behaviour leading to chronic pain disability. Pain-related fear elicits avoidance behaviour, which is typically aimed at reducing fear. We hypothesized that engaging in avoidance may (paradoxically) increase rather than decrease pain-related fear (i.e. bidirectionality hypothesis). In a between-subject design, participants (N=64) were randomly assigned to the avoidance group or the control group. Avoidance group participants were led to believe they could avoid full exposure to a painful heat stimulus by pressing the stop-button, while control group participants believed they were exposed to the full painful heat stimulus at all times...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29777606/human-capital-and-self-entrepreneurship-the-concept-of-robbed-time
#12
Alessio Musio
The notions of ″human capital″ and ″self-entrepreneurship″ are by now widespread. The present work takes a critical look at their pervasive acceptance and stresses the self-exploitation to which they give rise. The concept of self-entrepreneurship needs to take into account, in fact, the nature of a revolution in temporal phenomenology. This revolution not only blurs the distinction between time dedicated to life and time dedicated to one's profession. It means that time spent on whatever is traditionally irrelevant to work is potentially time robbed from successful self-entrepreneurship...
May 2018: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/29777527/limiting-motor-skill-knowledge-via-incidental-training-protects-against-choking-under-pressure
#13
Taraz G Lee, Daniel E Acuña, Konrad P Kording, Scott T Grafton
The paradoxical harmful effects of motivation and incentives on skilled performance ("choking under pressure") are observed in a wide variety of motor tasks. Two theories of this phenomenon suggest that choking under pressure occurs due to maladaptive attention and top-down control, either through distraction away from the task or interference via an overreliance on controlled processing of a skilled task. A third theory, overmotivation (or overarousal), suggests that under pressure, "instinctive" or Pavlovian approach/withdrawal responses compete with the desired response...
May 18, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29777127/paradoxical-cardiotoxicity-of-intraperitoneally-injected-epigallocatechin-gallate-preparation-in-diabetic-mice
#14
Nora O Abdel Rasheed, Lamiaa A Ahmed, Dalaal M Abdallah, Bahia M El-Sayeh
Numerous clinical and bioavailability studies addressed epigallocatechin gallate (EGCG) beneficial effects; however, our previous work revealed EGCG-induced nephrotoxicity in the presence of diabetes. In this study, the potential myocardial toxicity of EGCG preparation (100 mg/kg/day, IP; 4 days) in diabetic mice injected with streptozotocin (STZ; 150 mg/kg, IP) was investigated. Diabetic mice receiving EGCG preparation showed electrocardiographic changes in addition to elevation of both serum creatine kinase-MB and troponin-I levels accompanied by microscopic myocardial damage...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29774591/causal-estimands-and-confidence-intervals-associated-with-wilcoxon-mann-whitney-tests-in-randomized-experiments
#15
Michael P Fay, Erica H Brittain, Joanna H Shih, Dean A Follmann, Erin E Gabriel
Although the P value from a Wilcoxon-Mann-Whitney test is used often with randomized experiments, it is rarely accompanied with a causal effect estimate and its confidence interval. The natural parameter for the Wilcoxon-Mann-Whitney test is the Mann-Whitney parameter, ϕ, which measures the probability that a randomly selected individual in the treatment arm will have a larger response than a randomly selected individual in the control arm (plus an adjustment for ties). We show that the Mann-Whitney parameter may be framed as a causal parameter and show that it is not equal to a closely related and nonidentifiable causal effect, ψ, the probability that a randomly selected individual will have a larger response under treatment than under control (plus an adjustment for ties)...
May 17, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29773669/unresolved-endoplasmic-reticulum-stress-engenders-immune-resistant-latent-pancreatic-cancer-metastases
#16
Arnaud Pommier, Naishitha Anaparthy, Nicoletta Memos, Z Larkin Kelley, Alizée Gouronnec, Ran Yan, Cédric Auffray, Jean Albrengues, Mikala Egeblad, Christine A Iacobuzio-Donahue, Scott K Lyons, Douglas T Fearon
The majority of patients with pancreatic ductal adenocarcinoma (PDA) develop metastatic disease after resection of their primary tumor. We found that livers from patients and mice with PDA harbor single, disseminated cancer cells (DCCs) lacking expression of cytokeratin-19 (CK19) and major histocompatibility complex class I (MHCI). We created a mouse model to determine how these DCCs develop. Intra-portal injection of immunogenic PDA cells into pre-immunized mice seeded livers only with single, non-replicating DCCs that were CK19- and MHCI- The DCCs exhibited an endoplasmic reticulum (ER) stress response but, paradoxically lacked both inositol-requiring enzyme 1α activation and expression of the spliced form of transcription factor XBP1 (XBP1s)...
May 17, 2018: Science
https://www.readbyqxmd.com/read/29773645/the-hippo-pathway-effector-wwtr1-regulates-cardiac-wall-maturation-in-zebrafish
#17
Jason K H Lai, Michelle M Collins, Veronica Uribe, Vanesa Jiménez-Amilburu, Stefan Günther, Hans-Martin Maischein, Didier Y R Stainier
Cardiac trabeculation is a highly regulated process that starts with the delamination of compact layer cardiomyocytes. The Hippo signaling pathway has been implicated in cardiac development but many questions remain. We have investigated the role of Wwtr1, a nuclear effector of the Hippo pathway, in zebrafish and find that its loss leads to reduced cardiac trabeculation. However, in mosaic animals, wwtr1-/- cardiomyocytes contribute more frequently than wwtr1+/- cardiomyocytes to the trabecular layer of wild-type hearts...
May 17, 2018: Development
https://www.readbyqxmd.com/read/29773280/-paradoxical-effects-of-biotherapies-a-misnomer
#18
EDITORIAL
D Jullien
No abstract text is available yet for this article.
May 14, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29773149/paradoxical-effect-of-social-support-among-people-living-with-hiv-a-diary-study-investigating-the-buffering-hypothesis
#19
Marcin Rzeszutek, Ewa Gruszczyńska
OBJECTIVE: The aim of this study was to examine the buffering role of time-varying received and provided support in the relationship between stress and end-of-day mood among people living with HIV. In addition, the moderating role of intimate relationships in this buffering effect was verified. METHODS: The participants included 115 patients with a confirmed diagnosis of HIV infection. The data were collected using an online diary method. For five consecutive days (from Monday to Friday), participants completed an online time-stamped questionnaire in the evening to assess their end-of day-mood, stress related to a central hassle on any given day and social support that was received and provided...
June 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29772762/paradoxical-effect-of-chloroquine-treatment-in-enhancing-chikungunya-virus-infection
#20
Pierre Roques, Simon-Djamel Thiberville, Laurence Dupuis-Maguiraga, Fok-Moon Lum, Karine Labadie, Frédéric Martinon, Gabriel Gras, Pierre Lebon, Lisa F P Ng, Xavier de Lamballerie, Roger Le Grand
Since 2005, Chikungunya virus (CHIKV) re-emerged and caused numerous outbreaks in the world, and finally, was introduced into the Americas in 2013. The lack of CHIKV-specific therapies has led to the use of non-specific drugs. Chloroquine, which is commonly used to treat febrile illnesses in the tropics, has been shown to inhibit CHIKV replication in vitro. To assess the in vivo effect of chloroquine, two complementary studies were performed: (i) a prophylactic study in a non-human primate model (NHP); and (ii) a curative study "CuraChik", which was performed during the Reunion Island outbreak in 2006 in a human cohort...
May 17, 2018: Viruses
keyword
keyword
52316
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"