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https://www.readbyqxmd.com/read/29023983/age-vascular-health-and-alzheimer-s-disease-biomarkers-in-an-elderly-sample
#1
Prashanthi Vemuri, Timothy G Lesnick, Scott A Przybelski, David S Knopman, Val J Lowe, Jonathan Graff-Radford, Rosebud O Roberts, Michelle M Mielke, Mary M Machulda, Ronald C Petersen, Clifford R Jack
OBJECTIVE: To investigate the associations between age, vascular health, and Alzheimer's disease (AD) imaging biomarkers in an elderly sample. METHODS: We identified 430 individuals along the cognitive continuum aged>60 years with amyloid-PET, Tau-PET, and MRI scans from the population-based Mayo Clinic Study of Aging. A subset of 329 individuals had FDG-PET. We ascertained presently existing cardiovascular and metabolic conditions (CMC) from healthcare records and used the summation of presence/absence of hypertension, hyperlipidemia, cardiac-arrhythmias, coronary artery disease, congestive heart failure, diabetes mellitus, and stroke as a surrogate for vascular health...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29021864/sudden-failure-of-ventricular-pacing-and-recovery-in-a-patient-with-cardiac-sarcoidosis
#2
Yosuke Terui, Akihiro Nakamura, Hideaki Endo, Takahide Kadosaka, Takashi Nakata, Tasuku Watanabe, Kenjiro Sato, Masanori Kanazawa, Masateru Kondo, Tohru Takahashi, Eiji Nozaki
A 76-year-old woman with sarcoidosis who had an implantable pacemaker for complete atrioventricular block was admitted with syncope. Electrocardiogram revealed ventricular pacing failure, and a marked rise in the ventricular pacing threshold. (18)F-Fluorodeoxyglucose positron emission tomography (FDG-PET) indicated increased uptake of FDG in the ventricular septum. Three days after steroid therapy, the ventricular pacing threshold reverted to normal, and FDG-PET showed decreased FDG uptake in the ventricular septum...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28992382/arterial-inflammation-detected-with-18-f-fluoro-deoxyglucose-positron-emission-tomography-in-rheumatoid-arthritis
#3
Laura Geraldino-Pardilla, Afshin Zartoshti, Ayse Bag Ozbek, Jon T Giles, Richard Weinberg, Mona Kinkhabwala, Sabahat Bokhari, Joan M Bathon
OBJECTIVES: In addition to traditional risk factors, excess cardiovascular disease (CVD) in rheumatoid arthritis (RA) is attributed to enhanced vascular and/or systemic inflammation. In several small studies using (18) F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to directly assess vascular inflammation, FDG uptake was higher in RA patients than controls. Using a substantially larger RA sample, we sought to identify RA-disease characteristics independently associated with vascular FDG uptake...
October 9, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28990131/diagnosis-and-management-of-cognitive-and-behavioral-changes-in-dementia-with-lewy-bodies
#4
REVIEW
Babak Tousi
Proper diagnosis of dementia with Lewy bodies (DLB) in clinical practice remains suboptimal as many cases are misdiagnosed, usually as Alzheimer disease (AD) or Parkinson's disease (PD) and, in rare cases, psychosis. Therefore, it is important for patients with dementia to be thoroughly evaluated by a specialist who is familiar with current diagnostic tests and treatment options. New diagnostic criteria from the Dementia with Lewy Bodies Consortium have been developed to increase diagnostic sensitivity for DLB (Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium; McKeith et al...
October 9, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28989000/use-of-18-f-fdg-pet-ct-imaging-to-determine-internal-mammary-lymph-node-location-for-radiation-therapy-treatment-planning-in-breast-cancer-patients
#5
Tima Davidson, Merav Ben-David, Shira Galper, Tess Haskin, Megan Howes, Roland Scaife, Nayroz Kanana, Uri Amit, Noam Weizman, Bar Chikman, Elinor Goshen, Simona Ben-Haim, Zvi Symon, Jeffrey Goldstein
PURPOSE: Adjuvant internal mammary lymph node (IMN) radiation is often delivered with 2-dimensional techniques that use anatomic landmarks and predetermined depths for field placement and dose specification. In contrast, 3-dimensional planning uses the internal mammary vessels (IMVs) to localize the IMNs for planning. Our purpose was to determine if localization of the involved IMN (i-IMN) by (18)F-labeled fluorodeoxyglucose positron emission tomography-computed tomography ((18)F-FDG PET-CT) offers opportunities to improve treatment...
November 5, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28981185/infective-endocarditis-in-the-setting-of-renal-transplantation-case-report-and-review-of-the-literature
#6
Inbar Nardi Agmon, Elad Goldberg, Eytan Cohen, Ilan Krause
The potent immunosuppressive drugs used by transplant recipients places them at risk of infections. Data on infective endocarditis (IE) in the setting of renal transplantation (RT) are sparse. We describe a 36-year-old woman referred to a tertiary medical center for evaluation of elevated creatinine levels 1 month after a second RT. Work-up revealed the presence of all four of Duke's criteria: fever, persistent bacteremia, new-onset tricuspid regurgitation, and masses suspected to be vegetation attached to the tricuspid annulus...
October 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28956115/ct-myocardial-perfusion-imaging-ready-for-prime-time
#7
EDITORIAL
Richard A P Takx, Csilla Celeng, U Joseph Schoepf
The detection of functional coronary artery stenosis with coronary CT angiography (CCTA) is suboptimal. Additional CT myocardial perfusion imaging (CT-MPI) may be helpful to identify patients with myocardial ischaemia in whom coronary revascularization therapy would be beneficial. CT-MPI adds incremental diagnostic and prognostic value over obstructive disease on CCTA. It allows for the quantitation of myocardial blood flow and calculation of coronary flow reserve and shows good correlation with (15)O-H2O positron emission tomography and invasive fractional flow reserve...
September 27, 2017: European Radiology
https://www.readbyqxmd.com/read/28954832/a-54-year-old-man-with-new-onset-ventricular-fibrillation
#8
Kan Liu, Jamal Ahmed, David Feiglin
CLINICAL INTRODUCTION: A 54-year-old man without significant medical history presented with sudden-onset chest discomfort and multiple episodes of ventricular fibrillation requiring external defibrillation and cardiopulmonary resuscitation. Coronary angiography ruled out significant artery stenosis. Both ventriculography and echocardiography revealed decreased left ventricular ejection fraction (25%). On examination, he was haemodynamically stable. The lungs were clear to auscultation and there was no jugular venous dilation...
September 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28951515/merkel-cell-carcinoma-cardiac-metastasis-causing-cardiac-tamponade
#9
Murray Di Loreto, Roslyn Francis
We describe an unusual presentation of Merkel cell carcinoma (MCC), a rare neuroendocrine cutaneous tumour. A 59-year-old man presented with a 2-week history of dyspnoea on a background of MCC of the left elbow that was diagnosed after an axillary lymph node metastasis had appeared. He was clinically diagnosed with cardiac tamponade and received urgent pericardiocentesis. Thoracic CT imaging revealed a large infiltrating mass within the inferior aspect of the heart, confirmed to be MCC via immunohistochemistry of the pericardial fluid...
September 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28950301/heterogeneity-of-myocardial-2-18f-fluoro-2-deoxy-d-glucose-uptake-is-a-typical-feature-in-cardiac-sarcoidosis-a-study-of-231-patients
#10
Jukka V Schildt, Antti J Loimaala, Eero T Hippeläinen, Aapo A Ahonen
Aims: The goal of the investigation was to evaluate whether a semi-quantitative method reflecting myocardial 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake heterogeneity has added value in addition to visual analysis in the diagnosis of cardiac sarcoidosis (CS). Methods and results: This retrospective analysis included 271 consecutive patients suspected of CS attending cardiac positron emission tomography combined with computed tomography (PET-CT) at our institution between 2007 and 2013...
July 28, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28942939/relation-of-coronary-flow-reserve-to-other-findings-on-positron-emission-tomography-myocardial-perfusion-imaging-and-left-heart-catheterization-in-patients-with-end-stage-renal-disease-being-evaluated-for-kidney-transplant
#11
Yehuda Paz, Rachelle Morgenstern, Richard Weinberg, Mariana Chiles, Navdeep Bhatti, Ziad Ali, Sumit Mohan, Sabahat Bokhari
Cardiovascular disease is the leading cause of death in patients with end-stage renal disease (ESRD) and often goes undetected. Abnormal coronary flow reserve (CFR), which predicts increased risk of cardiac death, may be present in patients with ESRD without other evidence of coronary artery disease (CAD). We prospectively studied 131 patients who had rest and dipyridamole pharmacologic stress N(13)-ammonia positron emission tomography myocardial perfusion imaging (PET MPI) for kidney transplant evaluation...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28925529/cerebrovascular-response-to-the-cold-pressor-test-the-critical-role-of-carbon-dioxide
#12
Michael M Tymko, Thijs P Kerstens, Kevin W Wildfong, Philip N Ainslie
In addition to increasing sympathetic nervous activity, blood pressure, and cerebral blood flow (CBF), the cold pressor test (CPT) stimulates pain receptors, which may increase ventilation above metabolic demand; this response likely reduces the partial pressure of end-tidal carbon dioxide (PET CO2 ), and will attenuate elevations in CBF. We hypothesized: (1) CPT would elicit hyperventilation, effectively lowering PET CO2 ; (2) the CBF response will be elevated during an isocapnic (controlled PET CO2 ), compared to a poikilocapnic CPT (uncontrolled PET CO2 ); (3) In response to CPT, the common carotid artery (CCA) will vasodilatate, while the internal carotid artery (ICA) will remain unchanged to help regulate CBF...
September 19, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28923551/cardiac-melanoma-retrospective-review-of-a-rare-disease-at-the-mayo-clinic-1988-2015
#13
Chung Sang Tse, Nicholas Tan, Dame Idossa, Roger Click
BACKGROUND: Melanoma metastasizing to the heart (cardiac melanoma) is a rare entity that has been described only in autopsy studies or isolated pre-mortem case reports. We aim to better characterize cardiac melanoma, and describe its presenting features, imaging findings, and disease course with a case series collected over nearly 30years. METHODS: We performed a retrospective review of all patients diagnosed with cardiac melanoma at the Mayo Clinic from 1988 to 2015...
September 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28922191/acr-spr-str-practice-parameter-for-the-performance-of-cardiac-positron-emission-tomography-computed-tomography-pet-ct-imaging
#14
Rathan M Subramaniam, Warren R Janowitz, Geoffrey B Johnson, Martin A Lodge, Marguerite T Parisi, Mark R Ferguson, Jeffrey C Hellinger, Gregory W Gladish, Narainder K Gupta
This clinical practice parameter has been developed collaboratively by the American College of Radiology (ACR), the Society for Pediatric Radiology (SPR), and the Society of Thoracic Radiology (STR). This document is intended to act as a guide for physicians performing and interpreting positron emission tomography-computed tomography (PET/CT) of cardiac diseases in adults and children. The primary value of cardiac PET/CT imaging include evaluation of perfusion, function, viability, inflammation, anatomy, and risk stratification for cardiac-related events such as myocardial infarction and death...
September 15, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28913789/cardiac-sarcoidosis-after-glucocorticoid-therapy-evaluated-by-18-f-fluorodeoxyglucose-pet-mri
#15
Takatoyo Kiko, Atsuro Masuda, Ayaka Nemoto, Hideyuki Tominaga, Noboru Oriuchi, Akiomi Yoshihisa, Yasuchika Takeishi
No abstract text is available yet for this article.
September 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28905088/new-horizons-in-cardiac-innervation-imaging-introduction-of-novel-18-f-labeled-pet-tracers
#16
Ryohei Kobayashi, Xinyu Chen, Rudolf A Werner, Constantin Lapa, Mehrbod S Javadi, Takahiro Higuchi
Cardiac sympathetic nervous activity can be uniquely visualized by non-invasive radionuclide imaging techniques due to the fast growing and widespread application of nuclear cardiology in the last few years. The norepinephrine analogue (123)I-meta-iodobenzylguanidine ((123)I-MIBG) is a single photon emission computed tomography (SPECT) tracer for the clinical implementation of sympathetic nervous imaging for both diagnosis and prognosis of heart failure. Meanwhile, positron emission tomography (PET) imaging has become increasingly attractive because of its higher spatial and temporal resolution compared to SPECT, which allows regional functional and dynamic kinetic analysis...
September 13, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28899908/activation-of-the-splenocardiac-axis-by-electronic-and-tobacco-cigarettes-in-otherwise-healthy-young-adults
#17
Zachary Boas, Pawan Gupta, Roya S Moheimani, May Bhetraratana, Fen Yin, Kacey M Peters, Jeffrey Gornbein, Jesus A Araujo, Johannes Czernin, Holly R Middlekauff
The "Splenocardiac Axis" describes an inflammatory signaling network underlying acute cardiac ischemia, characterized by sympathetic nerve stimulation of hematopoietic tissues, such as the bone marrow and spleen, which then release proinflammatory monocytes that populate atherosclerotic plaques, thereby promoting ischemic heart disease. Electronic (e) cigarettes, like tobacco cigarettes trigger sympathetic nerve activation, but virtually nothing is known about their influence on hematopoietic and vascular tissues and cardiovascular risks...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28887581/multiple-skeletal-muscle-metastases-revealing-a-cardiac-intimal-sarcoma
#18
Amandine Crombé, Pierre-François Lintingre, François Le Loarer, Denis Lachatre, Benjamin Dallaudière
We report the case of a 59-year-old female with progressive bilateral painful swelling of the thighs. MRI revealed multiple intramuscular necrotic masses with similar morphologic patterns. Whole-body CT and 18-FDG PET-CT scans demonstrated additional hypermetabolic muscular masses and a lobulated lesion within the left atrial cavity. As biopsy of a muscular mass was compatible with a poorly differentiated sarcoma with MDM2 oncogene amplification, two diagnoses were discussed: a dedifferentiated liposarcoma with muscle and heart metastases or a primary cardiac sarcoma, mainly a cardiac intimal sarcoma, with muscular metastases, which was finally confirmed by array-comparative genomic hybridization (aCGH) in a sarcoma reference center...
September 8, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28880843/a-novel-dual-gating-approach-using-joint-inertial-sensors-implications-for-cardiac-pet-imaging
#19
Mojtaba Jafari Tadi, Jarmo Teuho, Eero Lehtonen, Antti Saraste, Mikko Pänkäälä, Tero Koivisto, Mika Teräs
Positron emission tomography (PET) is a non-invasive imaging technique which may be considered as the state of art for the examination of cardiac inflammation due to atherosclerosis. A fundamental limitation of PET is that cardiac and respiratory motions reduce the quality of the achieved images. Current approaches for motion compensation involve gating the PET data based on the timing of quiescent periods of cardiac and respiratory cycles. In this study, we present a novel gating method called microelectromechanical (MEMS) dual gating which relies on joint non-electrical sensors, i...
October 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28877068/mc225-a-novel-probe-for-p-glycoprotein-pet-imaging-at-the-blood-brain-barrier-in-vitro-cardiovascular-safety-evaluation
#20
Fabio Fusi, Miriam Durante, Beatrice Gorelli, Maria Grazia Perrone, Colabufo Nicola Antonio, Simona Saponara
The P-glycoprotein (P-gp) substrate MC225, at concentrations ≤ 10 nM, is a valuable radiotracer for positron emission tomography (PET) imaging of P-gp function in rats and mice.The aim of this study was to evaluate its potential toxic hazard towards the cardiovascular system through an in-depth analysis of its effects on rat aorta rings, on CaV1.2 channel current (ICa1.2) of A7r5 cells and on Langendorff perfused rat heart.In aortic rings, MC225 relaxed phenylephrine-induced contraction in a concentration-dependent and endothelium-independent manner, with an IC50 value of about 1 µM...
September 1, 2017: Journal of Cardiovascular Pharmacology
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