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https://www.readbyqxmd.com/read/27909290/highly-sensitive-detection-of-minimal-cardiac-ischemia-using-positron-emission-tomography-imaging-of-activated-platelets
#1
Melanie Ziegler, Karen Alt, Brett M Paterson, Peter Kanellakis, Alex Bobik, Paul S Donnelly, Christoph E Hagemeyer, Karlheinz Peter
A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in ischemic myocardium and a newly developed technology of non-invasive molecular PET imaging of activated platelets can thus detect minimal degrees of myocardial ischemia. To induce different degrees of minimal cardiac ischemia, the left anterior descending artery (LAD) was ligated for 10, 20 or 60 min...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908971/13n-ammonia-pet-ct-detection-of-myocardial-perfusion-abnormalities-in-beagle-dogs-after-local-heart-irradiation
#2
Jianbo Song, Rui Yan, Zhifang Wu, Jianguo Li, Min Yan, Xinzhong Hao, Jianzhong Liu, Sijin Li
: To determine the potential value of (13)N-ammonia positron emission tomography (PET)/computed tomography (CT) myocardial perfusion imaging (MPI) for detection of myocardial perfusion changes at early stage induced by radiation damage. METHODS: Thirty-six Beagle dogs were randomly divided into the control (n = 18) or the irradiation groups (n = 18). The irradiation group underwent local irradiation to the left ventricular anterior cardiac wall with a single dose of 20 Gy, whereas the control group received sham irradiation...
December 1, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27900641/cardiovascular-pet-mr-we-need-evidence-not-hype
#3
EDITORIAL
Afshin Farzaneh-Far, Raymond Y Kwong
Recent introduction of hybrid positron emission tomography/magnetic resonance (PET/MR) scanners has created excitement regarding potential applications in cardiovascular medicine. This has led to a number of optimistic assessments of its potential value in the nuclear cardiology literature, although most published data are still at the feasibility or pre-clinical level. Such excitement is understandable and provides "fuel" for generation of the necessary clinical validation studies, which will be required. Given the current scrutiny from payers and government agencies to reduce the costs of cardiac imaging, the responsibility for showing additive benefit lies on the shoulders of those advocating for new, more expensive technologies...
November 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27894597/unexpected-cardiac-death-during-anaesthesia-of-a-young-rabbit-associated-with-fibro-fatty-replacement-of-the-right-ventricular-myocardium
#4
M Romanucci, S V P Defourny, M Massimini, V Valerii, A Arbuatti, V Giordano, L Bongiovanni, C Perrone, L Della Salda
A 6-month-old female pet rabbit was presented for routine ovariectomy. The pre-anaesthetic evaluation was unremarkable and no anaesthetic complications occurred during the procedure. However, at the end of the surgery, the rabbit suddenly showed acute bradycardia and cardiac death. Necropsy examination revealed marked dilation of the right ventricle, associated with diffuse thinning of the right ventricular free wall. Gross and histopathological findings were suggestive of a congenital dilated cardiomyopathy characterized by fibro-fatty replacement of the right ventricular myocardium...
November 25, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27890686/cardiac-and-skeletal-muscles-metastases-from-squamous-cell-carcinoma-of-the-bladder-pet-ct-findings
#5
Luis Gorospe, Ernesto García-Santana, Pablo Jane-Soler, María Del Val Gómez-Martínez, Victoria Gómez-Dos-Santos, Isabel García-Gómez-Muriel, Raquel García-Latorre
We describe the PET/CT findings of a patient who underwent a radical cystectomy six months earlier because of a squamous cell carcinoma of the bladder (SCCB) that presented to the ER with chest pain and palpitations. Cardiac catheterization ruled out coronary artery occlusion, but PET/CT showed multiple FDG-avid lesions involving multiple skeletal muscles and the heart, consistent with metastases. A CT-guided biopsy of one skeletal muscle lesion confirmed a metastasis with the same pathologic features as the SCCB...
November 24, 2016: Urology
https://www.readbyqxmd.com/read/27888429/inappropriateness-of-diagnostic-imaging-examinations-in-the-inpatient-setting-a-case-study-research
#6
Ettore Squillaci, Francesca Bolacchi, Jacopo Scaggiante, Francesca Ricci, Luca Pugliese, Alberto Bergamini, Francesco Garaci, Roberto Floris
OBJECTIVE: The purpose of our study was to audit the clinical appropriateness of the prescriptions of whole body CT (WB-CT), PET-CT and chest X-rays (CXRs) performed at Tor Vergata University Hospital in the inpatient setting. MATERIALS AND METHODS: WB-CT, PET-CT and CXRs examinations were retrospectively analysed in the period between January and December 2014. CXR examinations were divided into bedside CXRs and traditional CXRs. The appropriateness of the examinations was defined according the American College of Radiology Appropriateness Criteria...
November 25, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27886616/serial-fdg-pet-scans-help-to-identify-steroid-resistance-in-cardiac-sarcoidosis
#7
Abhijeet B Shelke, Hrushikesh U Aurangabadkar, Jason S Bradfield, Zakir Ali, K Shiv Kumar, Calambur Narasimhan
BACKGROUND: Cardiac sarcoidosis (CS) is increasingly being recognized. Immunosuppression with corticosteroids is the mainstay of therapy. But the optimal dose of steroids and how to assess response to therapy is not known. Prognosis is poor if these patients are untreated or undertreated. Fluorine-18-flurodeoxyglucose positron emission computed tomography ((18)FDG-PET CT) is a sensitive tool in diagnosing CS. It correlates closely with the level of granulomatous inflammation and can be used to monitor response to therapy...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27870654/dietary-fatty-acid-metabolism-in-prediabetes
#8
Christophe Noll, André C Carpentier
PURPOSE OF REVIEW: Experimental evidences are strong for a role of long-chain saturated fatty acids in the development of insulin resistance and type 2 diabetes. Ectopic accretion of triglycerides in lean organs is a characteristic of prediabetes and type 2 diabetes and has been linked to end-organ complications. The contribution of disordered dietary fatty acid (DFA) metabolism to lean organ overexposure and lipotoxicity is still unclear, however. DFA metabolism is very complex and very difficult to study in vivo in humans...
November 18, 2016: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27867676/cardiac-magnetic-resonance-for-evaluating-catheter-related-fdg-avidity
#9
Daniel Jeong, Kenneth L Gage, Claudia G Berman, Jaime L Montilla-Soler
A 53-year-old female with a history of metastatic left arm melanoma presented for F(18) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) which showed a moderately FDG avid focus at her port catheter tip near the cavoatrial junction. Although catheter tip related FDG avidity has previously been suggested to be bland thrombus or infection, melanoma can metastasize to unusual locations including the superior vena cava. In addition, the patient had an elevated risk of anticoagulation due to a history of hemorrhagic brain metastases...
2016: Case Reports in Radiology
https://www.readbyqxmd.com/read/27858836/high-18f-fluorodeoxyglucose-uptake-in-cardiac-tumor-a-case-report
#10
Ying Liu, Hua Pang, Lu Xu, Qiong Liu, Wenbo Li
BACKGROUND: Cardiac tumors, especially malignant, are rare but aggressive tumors that mostly arise from the mesenchymal cells and represent a challenging diagnosis for clinicians. Recently, fluorine-18-fluorodiography positron emission tomography and computed tomography (F-FDG PET/CT) is an increasingly popular new technique with diagnosis of tumor. METHODS: We report a case of a right heart tumor showing intense uptake of F-fluorodeoxyglucose (F-FDG) on position emission tomography/computed tomography (PET/CT) imaging...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27852409/-application-value-of-combination-of-18-f-fdg-pet-and-ultrasound-cardiogram-in-the-assessment-of-patients-with-severe-coronary-heart-diseases
#11
Y X Ma, J S Mu, J Q Zhang, P Bo
Objective: To investigate the application value of combination of (18)F-FDG PET and ultrasound cardiogram in the assessment of patients with severe coronary heart diseases. Methods: A total of 38 patients with severe coronary heart diseases who were admitted to Beijing Anzhen Hospital from January 2015 to November 2015 were enrolled.There were 32 men and 6 women in this study, and the mean age was 33-73(59±10)years.All patients underwent coronary angiography, PET myocardial metabolic imaging, and echocardiography to evaluate the degree of myocardial ischemia, percentage of infarcted myocardium, left ventricular ejection fraction (LVEF), and left ventricular end-diastolic dimension (LVEDD)...
October 25, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27822623/-esc-and-aha-guidelines-2015-on-endocarditis-in-competition-or-synchrony
#12
Bernhard Maisch
In the 2015 guidelines of the European Society of Cardiology (ESC) and the American Heart Association (AHA) on infective endocarditis, the diagnostics are based on the modified Duke criteria. The diagnosis can be confirmed by a combination of micro-organisms demonstrated in culture or in situ, with the detection of valvular lesions or abscess formation by an imaging modality using echocardiography, positron emission tomography computed tomography (PET/CT), cardio-CT or nuclear medical methods. The management should be further improved by an interdisciplinary endocarditis team in a specifically designated reference center...
December 2016: Herz
https://www.readbyqxmd.com/read/27813028/the-role-of-serial-fdg-pet-for-assessing-therapeutic-response-in-patients-with-cardiac-sarcoidosis
#13
Pei-Ing Lee, Gang Cheng, Abass Alavi
BACKGROUND: The purpose of this study was to determine the feasibility of serial quantitative 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET) to monitor the response of cardiac sarcoidosis to treatment. METHODS AND RESULTS: A total of 38 PET scan intervals (54 PET scans) were obtained in 16 patients with cardiac sarcoidosis who underwent serial FDG PET during treatment. FDG-avid lesions of the heart were interpreted quantitatively using 4 PET parameters: maximum standardized uptake value (SUVmax), partial volume corrected mean standardized uptake value (SUVmean), partial volume corrected metabolic volume product (MVP), and global metabolic volume product (gMVP)...
November 3, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27809270/flexible-graphene-electrodes-for-prolonged-dynamic-ecg-monitoring
#14
Cunguang Lou, Ruikai Li, Zhaopeng Li, Tie Liang, Zihui Wei, Mingtao Run, Xiaobing Yan, Xiuling Liu
This paper describes the development of a graphene-based dry flexible electrocardiography (ECG) electrode and a portable wireless ECG measurement system. First, graphene films on polyethylene terephthalate (PET) substrates and graphene paper were used to construct the ECG electrode. Then, a graphene textile was synthesized for the fabrication of a wearable ECG monitoring system. The structure and the electrical properties of the graphene electrodes were evaluated using Raman spectroscopy, scanning electron microscopy (SEM), and alternating current impedance spectroscopy...
November 1, 2016: Sensors
https://www.readbyqxmd.com/read/27804070/effect-of-remote-ischemic-conditioning-on-myocardial-perfusion-in-patients-with-suspected-ischemic-coronary-artery-disease
#15
Kasper Pryds, Roni Ranghøj Nielsen, Camilla Molich Hoff, Lars Poulsen Tolbod, Kirsten Bouchelouche, Jing Li, Michael Rahbek Schmidt, Andrew N Redington, Jørgen Frøkiær, Hans Erik Bøtker
BACKGROUND: Remote ischemic conditioning (RIC) confers protection against myocardial ischemia-reperfusion injury and may modulate coronary blood flow. We investigated whether RIC affects resting myocardial perfusion (MP) in patients with suspected ischemic coronary artery disease by quantitative MP imaging. METHODS AND RESULTS: We included 49 patients with suspected ischemic coronary artery disease. Resting MP was quantified by (82)Rubidium positron emission tomography/computed tomography ((82)Rb-PET/CT) imaging before and after RIC, performed as four cycles of 5 minutes upper arm ischemia and reperfusion...
November 1, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27804054/regional-myocardial-damage-and-active-inflammation-in-patients-with-cardiac-sarcoidosis-detected-by-non-invasive-multi-modal-imaging
#16
Shohei Kataoka, Mitsuru Momose, Kenji Fukushima, Naoki Serizawa, Atsushi Suzuki, Chisato Kondo, Koichiro Abe, Shuji Sakai, Nobuhisa Hagiwara
AIMS: Cardiac sarcoidosis (CS) can be diagnosed using (18)F-FDG-PET/CT (PET), cardiovascular magnetic resonance (CMR), and (123)I-BMIPP/(201)TlCl dual myocardial SPECT. This study aims to clarify the relationships among the three modalities with respect to CS. METHODS AND RESULTS: We evaluated 16 patients (male n = 11; age 55 ± 13 years) with confirmed CS who underwent PET, CMR, and dual SPECT with gated SPECT before starting steroid therapy. The left ventricular myocardium was divided into 17 segments to obtain SUVmax for PET images, defect scores from 0 to 4 (0 normal; 4 absent), and mismatch scores for dual SPECT (BMDS, TLDS, and MS) images and late gadolinium enhancement (LGE) scores (0 none; 1 partly positive; 2 homogeneous) on CMR images...
November 1, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27801740/impact-of-time-of-flight-reconstruction-on-cardiac-pet-images-of-obese-patients
#17
Frank P DiFilippo, Richard C Brunken
PURPOSE: The benefit of time-of-flight (TOF) information in PET oncology studies is well established, demonstrating improved signal-to-noise ratio and enhanced lesion detection. In cardiac PET studies, tracer distribution and study interpretation differ substantially from oncology PET, and the benefit of TOF is less established. We investigate the impact of TOF on reconstructed myocardial distribution in Rb PET perfusion studies of obese patients, for whom TOF would have most significant impact...
October 31, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27801739/18f-florbetaben-a-new-tool-for-amyloidosis-staging
#18
Emmanuel D'Estanque, Benjamin Chambert, Olivier Moranne, Pierre Olivier Kotzki, Vincent Boudousq
We report the case of a 73-year-old man with a documented (renal biopsy) light-chain amyloidosis (AL) imaged with F-AV-1 (F-florbetaben) compared with a volunteer. A cardiac amyloidosis was suspected. As it was an AL and not a transthyretin amyloidosis, F-FDG and F-florbetaben PET/CT were preferred to bone scan. F-FDG scintigraphy showed a focal cardiac hypermetabolism. In addition of the heart, F-florbetaben scintigraphy showed an intense spleen and thyroid pathologic uptake and a moderate salivary gland and kidney uptake...
October 31, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27793567/-68-ga-labeled-fatty-acids-for-cardiac-metabolic-imaging-influence-of-different-bifunctional-chelators
#19
Akanksha Jain, Anupam Mathur, Usha Pandey, Haladhar Dev Sarma, Ashutosh Dash
Development of (68)Ga labeled fatty acids is of immense interest due to the availability of (68)Ga through a generator and its superiority over SPECT based tracers in carrying out dynamic imaging on a PET scanner. Our present work explores the influence of different chelators on the cardiac uptake and pharmacokinetics of the (68)Ga-labeled fatty acids. Two new (68)Ga labeled fatty acids were synthesized by conjugation of 11-aminoundecanoic acid with the bifunctional chelators (BFCs) viz. p-SCN-Bn-DTPA (S-2-(4-isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid) and p-SCN-Bn-NODAGA (S-2-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1-glutaric acid-4,7-acetic acid) and their comparison was carried out with the previously reported (68)Ga-NOTA-undecanoic acid...
October 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27780922/somatostatin-receptor-based-pet-ct-in-patients-with-the-suspicion-of-cardiac-sarcoidosis-an-initial-comparison-to-cardiac-mri
#20
Constantin Lapa, Theresa Reiter, Malte Kircher, Andreas Schirbel, Rudolf A Werner, Theo Pelzer, Carmen Pizarro, Dirk Skowasch, Lena Thomas, Ulrike Schlesinger-Irsch, Daniel Thomas, Ralph A Bundschuh, Wolfgang R Bauer, Florian C Gärtner
Diagnosis of cardiac sarcoidosis is often challenging. Whereas cardiac magnetic resonance imaging (CMR) and positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) are most commonly used to evaluate patients, PET/CT using radiolabeled somatostatin receptor (SSTR) ligands for visualization of inflammation might represent a more specific alternative. This study aimed to investigate the feasibility of SSTR-PET/CT for detecting cardiac sarcoidosis in comparison to CMR.15 patients (6 males, 9 females) with sarcoidosis and suspicion on cardiac involvement underwent SSTR-PET/CT imaging and CMR...
October 21, 2016: Oncotarget
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