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https://www.readbyqxmd.com/read/28323753/budget-impact-of-antiretroviral-therapy-in-a-french-clinic-cohort-anrs-gota
#1
Emmanuelle Papot, Roland Landman, Françoise Louni, Charlotte Charpentier, Gilles Peytavin, Agnès Certain, Clémence Fradet, Daniela Rojas Castro, Marie Preau, Cécile Goujard, Patrick Yeni, Yazdan Yazdanpanah
OBJECTIVES: In this study, we first assessed costs associated with the use of ART in an infectious diseases University Hospital Clinic, we secondly evaluated characteristics associated with these costs, and finally simulated the impact on the overall ART budget of switching 1- and 2-line regimens to less costly regimens (as effective and well-tolerated). DESIGN: Cohort analysis including PLHIV ≥ 18 years on ART to estimate ART costs during 2014. METHODS: This study was conducted in the Bichat-Claude Bernard University Hospital Clinic in Paris, France, where 4,501 PLHIV consulted in 2014...
March 18, 2017: AIDS
https://www.readbyqxmd.com/read/28323675/30-day-readmission-after-pancreatic-resection-a-systematic-review-of-the-literature-and-meta-analysis
#2
Alexander V Fisher, Sara Fernandes-Taylor, Stephanie A Campbell-Flohr, Sam J Clarkson, Emily R Winslow, Daniel E Abbott, Sharon M Weber
OBJECTIVE: The aim of this study was to identify and compare common reasons and risk factors for 30-day readmission after pancreatic resection. BACKGROUND: Hospital readmission after pancreatic resection is common and costly. Many studies have evaluated this problem and numerous discrepancies exist regarding the primary reasons and risk factors for readmission. METHODS: Multiple electronic databases were searched from 2002 to 2016, and 15 relevant articles identified...
March 20, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28323505/pattern-of-uveitis-in-a-referral-hospital-in-bangladesh
#3
Zahedur Rahman, Ziaul Ahsan, Niaz Abdur Rahman, Parthopratim Dutta Majumder
PURPOSE: To report the pattern of uveitis in a tertiary eye care center in Bangladesh. METHODS: Retrospective analysis of all uveitis cases visiting uveitis clinic of Bangladesh Eye Hospital between January, 2009 and April, 2015. RESULTS: In total, 652 patients (mean age 32.3 years, female 47.8%) were included in the study. Uveitis was bilateral in 42.6% of cases. Anterior uveitis was the most common (39.2%) case, closely followed by intermediate uveitis (22...
March 21, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28314974/health-related-quality-of-life-prospectively-evaluated-by-the-8-item-short-form-after-endovascular-repair-versus-open-surgery-for-abdominal-aortic-aneurysms
#4
Takayoshi Kato, Mototsugu Tamaki, Tomohiro Tsunekawa, Yusuke Motoji, Akihiro Hirakawa, Yasuhide Okawa, Shinji Tomita
Open repair for infra-renal abdominal aortic and iliac artery aneurysms (AAAs) is a robust treatment. On the other hand, endovascular aneurysm repair (EVAR) has been widespread because of its less invasiveness. However, patients after EVAR frequently require postoperative radiographic examinations and may feel anxiety for their endoleaks. We prospectively evaluated Health-related Quality of Life of the patients with these two fashions using the 8-item Short Form (SF-8). From 2011 to 2013, 89 consecutive elective cases of AAAs were treated...
March 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28304239/immunoglobulin-g4-related-epidural-inflammatory-pseudotumor-presenting-with-pulmonary-complications-and-spinal-cord-compression-case-report
#5
Kavelin Rumalla, Kyle A Smith, Paul M Arnold
Immunoglobulin G4-related disease (IgG4-RD) is a recently defined condition characterized by inflammatory tumefactive lesions in various organ systems. IgG4-RD is a clinical and radiological diagnosis of exclusion and requires the presence of specific histopathological criteria for diagnosis. A 50-year-old man presented to an outside hospital with a 3-month history of progressively worsening back pain and symptoms of pleurisy, nasal crusting, and hematochezia. Radiological workup revealed an epidural-paraspinal mass with displacement of the spinal cord, destruction of the T5-6 vertebrae, and extension into the right lung...
March 17, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28303812/global-eradication-of-measles-are-we-poised
#6
REVIEW
Raghavendra D Kulkarni, G S Ajantha, Aithal R Kiran, K R Pravinchandra
Measles, a highly infectious viral disease is the next target for eradication following poliovirus. Decades of experience with highly effective vaccination has invigorated us to take on this virus. The task is not only Titanic but is laced with intricate issues. Recently, an outbreak of fever with rash occurred on a tertiary care teaching hospital campus and was confirmed serologically as measles outbreak by IgMELISA. Therefore, we searched the literature related to outbreaks, transmission of the measles virus, age groups involved, vaccination strategies, vaccination failure and epidemiological features of the disease and reviewed the possible reasons for such outbreaks and problems in the global eradication of the virus...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28302522/is-there-a-relationship-between-genetic-factors-and-the-incidence-and-severity-of-h1n1-in-kosova-a-preliminary-investigation-and-pointers-for-further-research
#7
Shemsedin Dreshaj, Avdulla J Alija, Patricia Schlagenhauf, Teuta Doda, Njomeza Geca, Ismet Bajraktari, Nikolaus Bresgen, Peter M Eckl
BACKGROUND: Host genetic factors may impact susceptibility to infection. A small number of studies have investigated the association between factors such as ABO blood groups and selected phenotypes on the incidence and severity of H1N1 infections with inconclusive results. METHODS: Using data from the Clinic of Infectious Diseases - University Clinical Centre Prishtina and based on the examination of 125 patients hospitalized with H1N1 in the period 2009-2014, the frequency of blood groups from ABO and Rhesus (Rh) systems as phenotypical markers were evaluated...
March 14, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28298841/etiological-profile-of-noncompressive-myelopathies-in-a-tertiary-care-hospital-of-northeast-india
#8
Ashok Kumar Kayal, Munindra Goswami, Marami Das, Lakhshya Jyoti Basumatary, Suvorit Subhas Bhowmick, Baiakmenlang Synmon
BACKGROUND: The discovery of antibodies against aquaporin-4 and evolving concepts of noncompressive myelopathies in the 21(st) century have made a major impact on the etiological profile of these diseases, with few cases turning out to be idiopathic. OBJECTIVE: To find causes of noncompressive myelopathy in a tertiary care hospital of Northeast India. MATERIALS AND METHODS: An observational study was carried out in the Neurology Department of Gauhati Medical College, Guwahati, from September 2013 to February 2016...
January 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28294090/evaluation-of-staphylococcus-aureus-bacteremia-academic-and-community-based-management-within-the-same-health-system
#9
Sumaya Ased, Hamza Rayes, Jaspreet Dhami, Nick Amosson, Akua Fordjour, Jeff Macaraeg, Renuga Vivekanandan, Josh Wilson, Annie Cabri, Michele Davids, Jennifer Anthone, Stephen Cavalieri, Christopher J Destache
A nonrandomized, retrospective comparison of Staphylococcus aureus bacteremia between an academic hospital setting (n=53) and a community hospital setting (n=245) within a single healthcare system was performed. Despite infectious disease consultations, S. aureus bacteremia management recommendations based on Infectious Diseases Society of America (IDSA) guidelines were not followed as closely in the community hospital setting. The community hospital setting requires management standardization for patients with S...
March 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28286833/ventilator-associated-pneumonia-and-its-responsible-germs-an-epidemiological-study
#10
Rama Bozorgmehr, Vanousheh Bahrani, Alireza Fatemi
INTRODUCTION: Ventilator-associated pneumonia (VAP) is one of the most common hospital infections and a side effect of lengthy stay in intensive care unit (ICU). Considering the ever-changing pattern of common pathogens in infectious diseases and the raise in prevalence of hospital infections, the present study was designed aiming to determine the prevalence of VAP and its bacterial causes. METHODS: In this cross-sectional study, the medical profiles of all the patients under mechanical ventilation, who had no symptoms of pneumonia at the time of intubation and developed new infiltration in chest radiography after 48 hours under mechanical ventilation along with at least 2 of the symptoms including fever, hypothermia, leukocytosis, leukopenia, or purulent discharge from the lungs, were evaluated...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28286632/can-ratio-of-neutrophil-to-lymphocyte-count-and-erythrocyte-sedimentation-rate-in-diabetic-foot-infecti-on-predict-osteomyelitis-and-or-amputation
#11
Oktay Yapıcı, Hande Berk, Nefise Öztoprak, Derya Seyman, Alper Tahmaz, Alparslan Merdin
The aim of this study was to search for any relations between the neutrophil-to-lymphocyte ratio (NLR) and the development of osteomyelitis and the need for amputation in patients with diabetic foot infection (DFI). All data included DFI patients who were hospitalized in our Infectious Diseases Clinic between 2012 and 2015 and who were classified according to International Classification Disease Code System. 75 patients were analyzed in the study. The DFI patients were stratified into 3 groups of whom had amputation procedure, whom had only debridement/drainage procedure and whom had any surgery procedure...
February 23, 2017: Hematology Reports
https://www.readbyqxmd.com/read/28286295/impact-of-non-medical-vaccine-exemption-policies-on-the-health-and-economic-burden-of-measles
#12
Melanie D Whittington, Allison Kempe, Amanda Dempsey, Rachel Herlihy, Jonathan D Campbell
OBJECTIVE: Despite relatively high national vaccination coverage for measles, geographic vaccination variation exists resulting in clusters of susceptibility. A portion of this geographic variation can be explained by differences in state policies related to non-medical vaccine exemptions. The objective of this analysis was to determine the magnitude, likelihood, and cost of a measles outbreak under different non-medical vaccine exemption policies. METHODS: An agent-based transmission model simulated the likelihood and magnitude of a measles outbreak under different non-medical vaccine exemption policies, previously categorized as easy, medium, or difficult...
March 9, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28284852/current-methodologies-on-genotyping-for-nosocomial-pathogen-methicillin-resistant-staphylococcus-aureus-mrsa
#13
REVIEW
Jian Miao, Lequn Chen, Jingwen Wang, Wenxin Wang, Dingqiang Chen, Lin Li, Bing Li, Yang Deng, Zhenbo Xu
Methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen in hospitals and the community. As the rapid spread and wide distribution of antimicrobial resistance (such as MRSA), treatment for infectious diseases caused by microorganisms has become a vital threat. Thus, early identification and genotyping are essential for further therapeutic treatment and the control of rapid expansion of MRSA. In combination with applications and data feedbacks, this review focused on the currently available molecular-based assays on their utility and performance for rapid typing of MRSA, especially on effective molecular-based methods...
March 8, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28283829/the-efficacy-of-the-direct-clinical-intervention-for-infectious-diseases-by-a-pediatric-infectious-disease-specialist-in-the-pediatric-ward-of-a-tertiary-medical-facility-without-a-pediatric-antimicrobial-stewardship-program
#14
T Hoshina, N Yamamoto, M Ogawa, T Nakamoto, K Kusuhara
Antimicrobial stewardship programs (ASPs) have been introduced in most hospital complexes; however, they are not always useful for pediatric patients. The aim of this study is to investigate the efficacy of direct clinical intervention for infectious diseases by a pediatric infectious disease specialist in a tertiary medical facility without pediatric ASP. This retrospective study included 1,821 patients who were hospitalized in the pediatric ward of a large metropolitan hospital from 2010 to 2015. The clinical course, the use of intravenous antimicrobial agents and the results of a microbiological analysis were compared between the period after the beginning of direct intervention by the specialist (post-intervention period) and the previous period (pre-intervention period)...
March 10, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28283417/coexisting-infectious-diseases-on-admission-as-a-risk-factor-for-mechanical-ventilation-in-patients-with-guillain-barr%C3%A3-syndrome
#15
Shinichiro Kobori, Tatsuhiko Kubo, Makoto Otani, Keiji Muramatsu, Yoshihisa Fujino, Hiroaki Adachi, Hiromasa Horiguchi, Kiyohide Fushimi, Shinya Matsuda
BACKGROUND: The aim of this study was to investigate patient characteristics on admission to hospital that increase the risk of subsequent mechanical ventilation (MV) use for patients with Guillain-Barré syndrome (GBS). METHODS: We extracted data from the Japanese Diagnosis Procedure Combination (DPC) database for 4132 GBS patients admitted to hospital. Clinical characteristics of GBS patients with and without MV were compared. Multivariate logistic regression analyses were performed to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for the associations of requirement for MV with coexisting infectious diseases, after adjustment for potential confounding variables, age, sex, hospital type, and ambulance transportation...
March 7, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28283011/-investigation-of-seropositivity-of-bordetella-pertussis-in-adults-in-a-university-hospital
#16
Lütfiye Öksüz, Nezahat Gürler, Ali Ağaçfidan
Whooping cough is a vaccine-preventable infectious diseases caused by Bordetella pertussis/parapertussis. Despite of routine immunization programs in the world, pertussis still remains endemic. Recently unvaccinated or partially immunized infants have infected with this pathogen and also increase of incidence was observed in adolescents and adults. The source of pertussis in newborns are attributed to household, especially due to the family members. Theaim of this study was to determine B.pertussis IgG antibody positivity by ELISA method in adults...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28282467/effect-of-drinking-water-source-on-associations-between-gastrointestinal-illness-and-heavy-rainfall-in-new-jersey
#17
Jessie A Gleason, Jerald A Fagliano
Gastrointestinal illness (GI) has been associated with heavy rainfall. Storm events and periods of heavy rainfall and runoff can result in increased microbiological contaminants in raw water. Surface water supplies are open to the environment and runoff can directly influence the presence of contaminants. A time-stratified bi-directional case-crossover study design was used to estimate associations of heavy rainfall and hospitalizations for GI. Cases of GI were identified as in-patient hospitalization with a primary diagnosis of infectious disease associated diarrhea [ICD-9 codes: specified gastrointestinal infections 001-009...
2017: PloS One
https://www.readbyqxmd.com/read/28279787/implementation-of-a-cefazolin-based-stewardship-pathway-for-methicillin-susceptible-staphylococcus-aureus-bloodstream-infections-paired-with-infectious-diseases-consultation
#18
Benjamin J Lee, Sonia N Rao, Sheila K Wang, Jane Y Lee, Irfana Y Lakada, Elise M Gilbert, Viktorija O Barr, Michael J Postelnick, Sarah H Sutton, Teresa R Zembower, Maureen Bolon, Marc H Scheetz, Nathaniel J Rhodes
Methicillin-susceptible Staphylococcus aureus (MSSA) infections have been successfully treated both with cefazolin and antistaphylococcal penicillins; cefazolin appears effective in MSSA bloodstream infections (BSIs). Thus, our antimicrobial stewardship programme (ASP) implemented a clinical pathway supporting cefazolin use in MSSA-BSIs and restricting oxacillin use to infectious diseases (ID) consultation due to cefazolin's lower cost and more convenient dosing. This before and after quasi-experimental study was conducted to describe the impact on outcomes and process of care measures associated with implementing this pathway among patients with MSSA-BSI...
March 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28279155/acute-dental-infections-managed-in-an-outpatient-parenteral-antibiotic-program-setting-prospective-analysis-and-public-health-implications
#19
William J Connors, Heidi H Rabie, Rafael L Figueiredo, Donna L Holton, Michael D Parkins
BACKGROUND: The number of Acute Dental Infections (ADI) presenting for emergency department (ED) care are steadily increasing. Outpatient Parenteral Antibiotic Therapy (OPAT) programs are increasingly utilized as an alternative cost-effective approach to the management of serious infectious diseases but their role in the management of severe ADI is not established. This study aims to address this knowledge gap through evaluation of ADI referrals to a regional OPAT program in a large Canadian center...
March 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28279150/icares-a-real-time-automated-detection-tool-for-clusters-of-infectious-diseases-in-the-netherlands
#20
Geert H Groeneveld, Anton Dalhuijsen, Chakib Kara-Zaïtri, Bob Hamilton, Margot W de Waal, Jaap T van Dissel, Jim E van Steenbergen
BACKGROUND: Clusters of infectious diseases are frequently detected late. Real-time, detailed information about an evolving cluster and possible associated conditions is essential for local policy makers, travelers planning to visit the area, and the local population. This is currently illustrated in the Zika virus outbreak. METHODS: In the Netherlands, ICARES (Integrated Crisis Alert and Response System) has been developed and tested on three syndromes as an automated, real-time tool for early detection of clusters of infectious diseases...
March 9, 2017: BMC Infectious Diseases
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