Zheng Ao, Zhuhao Wu, Hongwei Cai, Liya Hu, Xiang Li, Connor Kaurich, Jackson Chang, Mingxia Gu, Cheng Liang, Xin Lu, Feng Guo
Tumor microenvironment crosstalk, in particular interactions between cancer cells, T cells, and myeloid-derived suppressor cells (MDSCs), mediates tumor initiation, progression, and response to treatment. However, current patient-derived models such as tumor organoids and 2D cultures lack some essential niche cell types (e.g., MDSCs) and fail to model complex tumor-immune interactions. Here, the authors present the novel acoustically assembled patient-derived cell clusters (APCCs) that can preserve original tumor/immune cell compositions, model their interactions in 3D microenvironments, and test the treatment responses of primary tumors in a rapid, scalable, and user-friendly manner...
May 25, 2022: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)