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https://www.readbyqxmd.com/read/29668894/endoscopic-treatment-of-ileal-pouch-sinus
#1
Nan Lan, Bo Shen
Background and aims: Pouch sinus is a serious complication in patients undergoing ileal pouch-anal anastomosis. The aim of this study was to verify the efficacy and safety of endoscopic needle knife sinusotomy (NKSi) in the management of pouch sinus. Methods: All consecutive patients with a pouch sinus treated with NKSi from 2008 to 2016 were identified. The primary outcomes were complete healing of the sinus and pouch survival. Results: A total of 109 patients were included...
April 12, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668597/hiv-syphilis-and-behavioral-risk-factors-among-men-who-have-sex-with-men-in-a-drug-using-area-of-southwestern-china-results-of-3-cross-sectional-surveys-from-2013-to-2015
#2
Lan Guanghua, Chen Yi, Tang Shuai, Shen Zhiyong, Tang Zhenzhu, Ruan Yuhua, Mohammed Adnan Yousuf, Fan Wensheng
To assess human immunodeficiency virus (HIV), syphilis, and behavioral risk factors among men who have sex with men (MSM) in southwestern China, where HIV started as a drug-driven epidemic, and shifted to mainly heterosexual transmission.These cross-sectional studies were conducted yearly in 2013, 2014, and 2015 in Guangxi, China. A total of 1,996, 1,965, and 1,697 participants were recruited in 2013, 2014, and 2015, respectively. The data included demographic and sexual behavioral variables. Other variables included individuals who used illegal drugs, and who received HIV counseling, testing, and free condoms, and peer education...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668581/clearance-of-human-papillomavirus-related-anal-condylomas-after-oral-and-endorectal-multistrain-probiotic-supplementation-in-an-hiv-positive-male-a-case-report
#3
Giancarlo Ceccarelli, Eugenio Nelson Cavallari, Stefano Savinelli, Luigi Bianchi, Alessandra Pierangeli, Francesco Vullo, Antonio Ciardi, Gabriella D'ettorre
INTRODUCTION: Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple reactive lymphoadenopathies and large intra-anal condylomas. The patient was treated with a complete excision of Bowen's lesion and with a 4 months course of supplementation with a high concentration multistrain probiotic formulation administered orally and by rectal instillation with the purpose to reduce local inflammation and to enhance local mucosal immunity...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29660321/reliability-among-central-readers-in-the-evaluation-of-endoscopic-disease-activity-in-pouchitis
#4
Mark A Samaan, Bo Shen, Mahmoud H Mosli, Guangyong Zou, William J Sandborn, Lisa M Shackelton, Sigrid Nelson, Larry Stitt, Stuart Bloom, Darrell S Pardi, Paolo Gionchetti, James Lindsay, Simon Travis, Ailsa Hart, Mark S Silverberg, Brian G Feagan, Geert R D'Haens, Vipul Jairath
BACKGROUND & AIMS: Pouchitis is a common adverse event after proctocolectomy with ileal pouch anal anastomosis for ulcerative colitis. Evaluation of pouchitis disease activity and response to treatment requires use of validated indices. We assessed the reliability of items evaluating endoscopic pouchitis disease activity. METHODS: Twelve panelists used a modified RAND appropriateness methodology to rate the appropriateness of items evaluating endoscopic pouchitis disease activity derived from a systematic review, and also identified additional potential endoscopic items based on expert opinion...
April 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29659752/performance-of-anal-cytology-compared-with-high-resolution-anoscopy-and-histology-in-women-with-lower-anogenital-tract-neoplasia
#5
Andreia Albuquerque, Michael Sheaff, Oliver Stirrup, Carmelina Cappello, Julie Bowring, Tamzin Cuming, Anke de Masi, Adam N Rosenthal, Mayura Nathan
Background: Information on the performance of anal cytology in women who are high-risk for human papillomavirus-related lesions and the factors that might influence it are largely lacking. Aims: Evaluate the performance of anal cytology in women with lower anogenital tract neoplasia. Methods: retrospective study including all new referrals of women with a previous history of anogenital neoplasia, from January 2012 to July 2017, with concomitant anal cytology and high-resolution anoscopy with or without biopsies...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29652190/anal-cytology-institutional-statistics-correlation-with-histology-and-development-of-multidisciplinary-screening-program-with-review-of-the-current-literature
#6
Elizabeth G Morency, Tracey Harbert, Nazneen Fatima, Julia Samolcyzk, Kruti P Maniar, Ritu Nayar
CONTEXT: - The incidence of anal cancer in the United States is on the rise in high-risk populations. The anal Papanicolaou test (APT) is advocated as a screening tool, in addition to digital rectal examination and high-resolution anoscopy. OBJECTIVE: - To review our experience and the current literature to create, in cooperation with clinicians, a standardized screening and treatment algorithm given our large volume of APTs. DATA SOURCES: - All APTs collected between January 2013 and June 2015 were reviewed and correlated with follow-up/concurrent biopsy diagnoses, and clinical and social history...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29652112/mucopexy-recto-anal-lifting-mu-ral-a-standardized-minimally-invasive-method-of-managing-symptomatic-hemorrhoids-with-an-innovative-suturing-technique-and-the-hemorpex-system%C3%A2
#7
Claudio Pagano, Contardo Vergani, Carlo Invernizzi, Massimo Bussone, Guido Benegiamo, Marco Venturi
BACKGROUND: Conservative surgery of hemorrhoidal disease is less painful than traditional hemorrhoidectomy, and mucopexy has less risk of serious postoperative complications than stapled hemorrhoidopexy. The aim of this study was to evaluate the safety and effectiveness of a standardized, modified hemorrhoidopexy, named Mucopexy-Recto Anal Lifting (MuRAL),with the HemorPex System (HPS) in patients with symptomatic III and IV degree hemorrhoids. MATERIALS AND METHODS: Patients were enrolled from May 2013 to Dec 2015 and operated on with the MuRAL technique, based on arterial ligation and mucopexy at 6 locations, using a standardized clockwise/anti-clockwise rotation sequence of the HPS anoscope...
April 12, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29618817/fatal-swine-acute-diarrhoea-syndrome-caused-by-an-hku2-related-coronavirus-of-bat-origin
#8
Peng Zhou, Hang Fan, Tian Lan, Xing-Lou Yang, Wei-Feng Shi, Wei Zhang, Yan Zhu, Ya-Wei Zhang, Qing-Mei Xie, Shailendra Mani, Xiao-Shuang Zheng, Bei Li, Jin-Man Li, Hua Guo, Guang-Qian Pei, Xiao-Ping An, Jun-Wei Chen, Ling Zhou, Kai-Jie Mai, Zi-Xian Wu, Di Li, Danielle E Anderson, Li-Biao Zhang, Shi-Yue Li, Zhi-Qiang Mi, Tong-Tong He, Feng Cong, Peng-Ju Guo, Ren Huang, Yun Luo, Xiang-Ling Liu, Jing Chen, Yong Huang, Qiang Sun, Xiang-Li-Lan Zhang, Yuan-Yuan Wang, Shao-Zhen Xing, Yan-Shan Chen, Yuan Sun, Juan Li, Peter Daszak, Lin-Fa Wang, Zheng-Li Shi, Yi-Gang Tong, Jing-Yun Ma
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health1 . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)2-10 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms...
April 4, 2018: Nature
https://www.readbyqxmd.com/read/29617820/fecal-incontinence-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#9
Phillip Gu, M Ellen Kuenzig, Gilaad G Kaplan, Mark Pimentel, Ali Rezaie
Background: Understanding of the prevalence, pathophysiology, and management of fecal incontinence (FI) in inflammatory bowel disease (IBD) patients without an ileal pouch anal anastomosis (IPAA) is suboptimal. We conducted a systematic review and meta-analysis on the prevalence, pathophysiology, and management of primary FI in IBD patients without IPAA. Methods: We searched MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews (1966 through March 2017) for studies on the prevalence, physiology, or management of FI in IBD patients without IPAA...
March 30, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29615297/is-there-synergy-in-syndemics-psychosocial-conditions-and-sexual-risk-among-men-who-have-sex-with-men-in-india
#10
Cecilia Tomori, Allison M McFall, Sunil S Solomon, Aylur K Srikrishnan, Santhanam Anand, P Balakrishnan, Shruti H Mehta, David D Celentano
Syndemic theory describes the clustering and synergistic interaction of disease driven by contextual and social factors, which worsen health outcomes for a population, and has been applied to men who have sex with men (MSM) and their risk for HIV and other sexually transmitted infections. Recent reviews, however, have critiqued prevailing approaches in syndemic studies that assess only additive associations without evaluation of synergy. Following these suggestions, we compared the traditional additive approach with a test for synergistic association of 5 syndemic conditions (alcohol dependence, illicit drug use, depression, intimate partner violence (IPV), and childhood sexual abuse (CSA)) with unprotected anal intercourse (UAI) and active syphilis infection among 11,771 MSM recruited through respondent driven sampling from 12 cities in India...
March 23, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29607650/factors-associated-with-high-grade-anal-intraepithelial-lesion-in-hiv-positive-men-in-a-southern-u-s-city
#11
Melanie Ann Frank, Cecile Lahiri, Minh Ly Nguyen, C Christina Mehta, Marina Mosunjac, Lisa Flowers
The incidence of anal cancer is increased in HIV-infected patients compared to the general population. Risk factors associated with the anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), have not been extensively studied in an urban black population with late stage HIV disease. We performed a retrospective chart review of HIV infected men at the Grady Ponce de Leon Center HIV Clinic in Atlanta, Georgia referred for high resolution anoscopy (HRA), a procedure where anal tissue is examined under magnification and abnormal areas are biopsied...
April 1, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29594584/genital-marginal-failures-after-intensity-modulated-radiation-therapy-imrt-in-squamous-cell-anal-cancer-no-higher-risk-with-imrt-when-compared-to-3dcrt
#12
V Dell'Acqua, J Kobiela, F Kraja, M C Leonardi, A Surgo, M A Zerella, S Arculeo, C Fodor, R Ricotti, M G Zampino, S Ravenda, G Spinoglio, R Biffi, A Bazani, R Luraschi, S Vigorito, P Spychalski, R Orecchia, R Glynne-Jones, B A Jereczek-Fossa
Intensity-modulated radiotherapy (IMRT) is considered the preferred option in squamous cell canal cancer (SCAC), delivering high doses to tumor volumes while minimizing dose to surrounding normal tissues. IMRT has steep dose gradients, but the technique is more demanding as deep understanding of target structures is required. To evaluate genital marginal failure in a cohort of patients with non-metastatic SCAC treated either with IMRT or 3DCRT and concurrent chemotherapy, 117 patients with SCAC were evaluated: 64 and 53 patients were treated with IMRT and 3DCRT techniques, respectively...
March 28, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29573536/outcome-of-surgery-for-recurrent-anal-cancer-results-from-a-tertiary-referral-centre
#13
M Bignell, H Chave, G Branagan
AIM: Chemoradiotherapy remains the first line treatment for anal cancer with surgery reserved for cancer recurrence or persistence. The low incidence of anal cancer means the numbers undergoing surgery is small with centralization for excision to regional cancer centres. We present our experience of abdominal perineal excision, with reconstruction of the perineal defect (APERR), within a tertiary centre. METHOD: Over a fifteen year period data were collected retrospectively from notes of patients who underwent an APERR...
March 24, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29569419/patients-with-perianal-crohn-s-fistulae-experience-delays-in-accessing-anti-tnf-therapy-due-to-slow-recognition-diagnosis-and-integration-of-specialist-services-lessons-learned-from-three-referral-centres
#14
Matthew J Lee, Clare Freer, Sam Adegbola, Soad Elkady, Miles Parkes, Ailsa Hart, Nicola S Fearnhead, Alan J Lobo, Steven R Brown
BACKGROUND: Crohn's anal fistula should be managed with a multidisciplinary team. There is no clearly defined 'patient pathway' from presentation to treatment. The aim of this study was to describe the patient route from presentation with symptomatic Crohn's anal fistula to starting anti-TNF therapy. METHOD: Case note review was undertaken at three hospitals with established IBD services. Patients with Crohn's anal fistula presenting between 2010 and 2015 were identified through clinical coding and local databases...
March 22, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29566456/systematic-review-of-outcome-measures-following-chemo-radiotherapy-for-the-treatment-of-anal-cancer-cormac
#15
REVIEW
R Fish, C Sanders, N Ryan, S Van der Veer, A G Renehan, P R Williamson
AIM: Six phase III randomised trials have determined the effectiveness of chemoradiotherapy as primary treatment for anal squamous cell carcinoma (ASCC), but outcomes reported in these trials varied widely, hindering evidence synthesis. To improve reporting in all future trials, we aim to develop a core set of outcomes (COS). As the first stage of COS development, we undertook a systematic review to summarise the outcomes reported in studies evaluating chemoradiotherapy for ASCC. METHOD: Systematic literature searches identified studies evaluating radiotherapy or chemoradiotherapy for ASCC...
March 22, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29564356/chinese-research-into-severe-ulcerative-colitis-has-increased-in-quantity-and-complexity
#16
Cheng-Xin Luo, Zhong-Hui Wen, Yu Zhen, Zhu-Jun Wang, Jing-Xi Mu, Min Zhu, Qin Ouyang, Hu Zhang
AIM: To investigate the current state of research output from Chinese studies into severe ulcerative colitis (SUC) using a bibliometric analysis of publications. METHODS: The contents of the Chinese periodical databases WANFANG, VIP, and China National Knowledge Infrastructure were searched for all papers regarding UC or SUC published in last the 15 years (from 2001 to 2015). The number of publications in each year was recorded to assess the temporal trends of research output...
March 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29563038/clinical-manifestations-pathophysiology-treatment-and-outcome-of-inflammatory-bowel-diseases-in-older-people
#17
REVIEW
Matthias Butter, Stefan Weiler, Luc Biedermann, Michael Scharl, Gerhard Rogler, Heike A Bischoff-Ferrari, Benjamin Misselwitz
Approximately 10-20% of inflammatory bowel disease (IBD) cases are diagnosed after 60 years of age. Due to the high prevalence of conditions mimicking IBD at older age - including bowel disease associated with non-steroidal anti-inflammatory drugs, diverticulitis, and microscopic colitis - differential diagnosis of IBD among older adults is frequently delayed. Late-onset IBD is characterized by a predominance of colonic disease and an overall milder disease course; disease progression and new intestinal manifestations are rare...
April 2018: Maturitas
https://www.readbyqxmd.com/read/29560668/lymphogranuloma-venereum-among-patients-presenting-at-the-hiv-sti-clinic-in-antwerp-belgium-a-case-series
#18
Ludwig Apers, Eric Florence, Tania Crucitti, Nabila Anwar
Objective of this study was to describe the patient characteristics and clinical presentation of laboratory confirmed lymphogranuloma venereum (LGV) cases, diagnosed at the Institute of Tropical Medicine (ITM), Antwerp, Belgium. Demographic and biomedical characteristics of all patients with chlamydia-positive sample results were retrieved for the years 2013 and 2014. Samples were obtained from both symptomatic and asymptomatic patients who consulted at the HIV/STI clinic. Fifty four patients with laboratory confirmed LGV were detected among 3885 nucleic acid amplification tests (NAATs) performed for the detection of chlamydia during the two years under review...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29555573/whole-exome-sequencing-identified-mutational-profiles-of-squamous-cell-carcinomas-of-anus
#19
Sun Shin, Hyeon-Chun Park, Min Sung Kim, Mi-Ryung Han, Sung Hak Lee, Seung Hyun Jung, Sug Hyung Lee, Yeun-Jun Chung
Anal squamous cell carcinoma (ASCC), either with human papillomavirus (HPV) (+) or (-), is a neoplastic disease with frequent recurrence and metastasis. To characterize ASCC genomes, we attempted to disclose novel alterations of ASCC genomes as well as other genetic features including mutation signatures. We performed whole-exome sequencing and copy number alteration (CNA) profiling for 8 ASCC samples from 6 patients (2 cases with primary and recurrent/metastatic tumors). We found known ASCC mutations (TP53, CDKN2A and PIK3CA) and CNAs (gains on 3q and 19q and losses on 11q and 13q)...
March 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29555552/incidence-of-type-1-diabetes-mellitus-in-navarre-stabilized-in-the-last-eight-years
#20
Luis Forga, Ibai Tamayo, María Chueca, Berta Ibáñez, Amaya Sainz de Los Terreros, María José Goñi
OBJECTIVES: Incidence of type 1 diabetes mellitus raises a number of controversies. Our study aim was to contribute to answer the following questions: Is incidence of T1DM increasing? Is age at onset of type 1 diabetes mellitus decreasing? Which are the sex differences? Which are the characteristics in adults? METHODS: A cross-sectional descriptive study using data from a primary source and 3 secondary sources from Navarre collected between 01/01/2009 and 12/31/2016...
March 16, 2018: Endocrinología, Diabetes y Nutrición
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