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First-episode schizophrenia

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https://www.readbyqxmd.com/read/28730732/shared-atypical-default-mode-and-salience-network-functional-connectivity-between-autism-and-schizophrenia
#1
Heng Chen, Lucina Q Uddin, Xujun Duan, Junjie Zheng, Zhiliang Long, Youxue Zhang, Xiaonan Guo, Yan Zhang, Jingping Zhao, Huafu Chen
Schizophrenia and autism spectrum disorder (ASD) are two prevalent neurodevelopmental disorders sharing some similar genetic basis and clinical features. The extent to which they share common neural substrates remains unclear. Resting-state fMRI data were collected from 35 drug-naïve adolescent participants with first-episode schizophrenia (15.6 ± 1.8 years old) and 31 healthy controls (15.4 ± 1.6 years old). Data from 22 participants with ASD (13.1 ± 3.1 years old) and 21 healthy controls (12...
July 21, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28729037/increased-gyrification-in-schizophrenia-and-non-affective-first-episode-of-psychosis
#2
Riccardo Zuliani, Giuseppe Delvecchio, Carolina Bonivento, Giulia Cattarinussi, Cinzia Perlini, Marcella Bellani, Veronica Marinelli, Maria Gloria Rossetti, Antonio Lasalvia, Andrew McIntosh, Stephen M Lawrie, Matteo Balestrieri, Mirella Ruggeri, Paolo Brambilla
BACKGROUND: Prefrontal cortex gyrification has been suggested to be altered in patients with schizophrenia and first episode psychosis. Therefore, it may represent a possible trait marker for these illnesses and an indirect evidence of a disrupted underlying connectivity. The aim of this study was to add further evidence to the existing literature on the role of prefrontal gyrification in psychosis by carrying out a study on a sizeable sample of chronic patients with schizophrenia and non-affective first-episode psychosis (FEP-NA) patients...
July 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28728089/volumetric-and-morphological-characteristics-of-the-hippocampus-are-associated-with-progression-to-schizophrenia-in-patients-with-first-episode-psychosis
#3
R Sauras, A Keymer, A Alonso-Solis, A Díaz, C Molins, F Nuñez, M Rabella, A Roldán, E Grasa, E Alvarez, M J Portella, I Corripio
BACKGROUND: Abnormalities in the hippocampus have been implicated in the pathophysiology of psychosis. However, it is still unclear whether certain abnormalities are a pre-existing vulnerability factor, a sign of disease progression or a consequence of environmental factors. We hypothesized that first-episode psychosis patients who progress to schizophrenia after one year of follow up will display greater volumetric and morphological changes from the very beginning of the disorder. METHODS: We studied the hippocampus of 41 patients with a first-episode psychosis and 41 matched healthy controls...
July 5, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28724123/assessment-of-insulin-resistance-among-drug-naive-patients-with-first-episode-schizophrenia-in-the-context-of-hormonal-stress-axis-activation
#4
Johann Steiner, Maximus Berger, Paul C Guest, Henrik Dobrowolny, Sabine Westphal, Kolja Schiltz, Zoltán Sarnyai
No abstract text is available yet for this article.
July 19, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28719155/antipsychotic-treatment-is-associated-with-inflammatory-and-metabolic-biomarkers-alterations-among-first-episode-psychosis-patients-a-7-month-follow-up-study
#5
Roman Balõtšev, Liina Haring, Kati Koido, Vambola Leping, Kärt Kriisa, Mihkel Zilmer, Veiko Vasar, Anneli Piir, Aavo Lang, Eero Vasar
AIM: Second-generation antipsychotics are commonly used to treat schizophrenia, but may cause metabolic syndrome (MetS) in a subset of patients. The mechanisms of antipsychotic-related metabolic changes remain to be established, especially in first-episode psychosis (FEP) patients. METHODS: In the present study, we used a chip technology to measure metabolic (C-peptide, insulin, leptin, adiponectin and resistin) and inflammatory biomarkers (ferritin, interleukin-6, interleukin-1α, tumour necrosis factor-α and plasminogen activator inhibitor-1) in the serum samples of a population of FEP patients before and after 7 months of antipsychotic drug treatment, compared to control subjects (CS)...
July 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28713691/cognitive-correlates-of-neuroimaging-abnormalities-in-the-onset-of-schizophrenia-a-case-report
#6
Silvia Grassi, Giulia Orsenigo, Marta Serati, Elisabetta Caletti, Alfredo Carlo Altamura, Massimiliano Buoli
Increasing evidence shows that cognitive impairment and brain abnormalities can appear early in the first episodes of schizophrenia, but it is currently debated how brain changes can correlate with clinical presentation of schizophrenic patients. Of note, this report describes the case of a young schizophrenic male presenting parietal magnetic resonance/positron emission tomography abnormalities and cognitive impairment, documented by specific neuropsychological tests. In our knowledge only few studies have investigated if neuropsychological abnormalities could be concomitant with both structural and functional neuroimaging...
June 22, 2017: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28712363/overlapping-and-disease-specific-trait-response-and-reflection-impulsivity-in-adolescents-with-first-episode-schizophrenia-spectrum-disorders-or-attention-deficit-hyperactivity-disorder
#7
J R M Jepsen, J Rydkjaer, B Fagerlund, A K Pagsberg, R Av F Jespersen, B Y Glenthøj, B Oranje
BACKGROUND: Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) are developmental disorders with shared clinical characteristics such as cognitive impairments and impulsivity. Impulsivity is a core feature of ADHD and an important factor in aggression, violence, and substance use in schizophrenia. Based on the hypothesis that schizophrenia and ADHD represent a continuum of neurodevelopmental impairments, the aim was to identify overlapping and disease specific forms of impulsivity...
July 17, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28709773/demographic-psychosocial-clinical-and-neurocognitive-baseline-characteristics-of-black-americans-in-the-raise-etp-study
#8
Arundati Nagendra, Nina R Schooler, John M Kane, Delbert G Robinson, Kim T Mueser, Sue E Estroff, Jean Addington, Patricia Marcy, David L Penn
This study compared baseline characteristics of Black Americans and Caucasians with first-episode psychosis in the Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP). Black American (N=152) and Caucasian (N=218) participants were compared on demographic, psychosocial, clinical, and neurocognitive measures. Results indicated several notable racial differences in baseline characteristics: a greater proportion of Black Americans than Caucasians were female, and Black Americans reported less personal and parental education than Caucasians...
July 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28707138/gray-matter-changes-and-cognitive-predictors-of-2-year-follow-up-abnormalities-in-early-onset-first-episode-psychosis
#9
Josefina Castro-Fornieles, Nuria Bargalló, Anna Calvo, Celso Arango, Immaculada Baeza, Ana Gonzalez-Pinto, Mara Parellada, Montserrat Graell, Carmen Moreno, Soraya Otero, Joost Janssen, Marta Rapado-Castro, Elena de la Serna
This study aims to examine regional gray matter (GM) changes over a period of 2 years in patients diagnosed with early-onset first-episode psychosis (EO-FEP), and to identify baseline predictors of abnormalities at the follow-up. Fifty-nine patients with EO-FEP aged 11-17 years were assessed. Magnetic resonance imaging was carried out at admission and 2 years later. Changes over time were assessed with voxel-based morphometry. Fifty-nine patients (34 schizophrenia-SCZ, 15 bipolar disorder-BP, and 10 other psychotic disorders) and 70 healthy controls were assessed...
July 13, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28703015/guidelines-for-the-pharmacotherapy-of-schizophrenia-in-adults
#10
Gary Remington, Donald Addington, William Honer, Zahinoor Ismail, Thomas Raedler, Michael Teehan
OBJECTIVE: The present guidelines address the pharmacotherapy of schizophrenia in adults across different stages, phases, and symptom domains. METHOD: Guidelines were developed using the ADAPTE process, which takes advantage of existing guidelines. Six guidelines were identified for adaptation, with recommendations extracted from each. For those specific to the pharmacotherapy of schizophrenia in adults, a working group selected between guidelines and recommendations to create an adapted guideline...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28701275/is-going-into-stable-symptomatic-remission-associated-with-a-more-positive-development-of-life-satisfaction-a-10-year-follow-up-study-of-first-episode-psychosis
#11
Erlend Strand Gardsjord, Kristin Lie Romm, Jan Ivar Røssberg, Svein Friis, Helene Eidsmo Barder, Julie Evensen, Ulrik Haahr, Wenche Ten Velden Hegelstad, Inge Joa, Jan Olav Johannessen, Johannes Langeveld, Tor Ketil Larsen, Stein Opjordsmoen, Bjørn Rishovd Rund, Erik Simonsen, Per Vaglum, Thomas McGlashan, Ingrid Melle
BACKGROUND: Quality of life is an important outcome measure for patients with psychosis. We investigated whether going into stable symptomatic remission is associated with a more positive development of subjective quality of life (S-QoL) and if different patient characteristics are associated with S-QoL depending on remission status. METHODS: Three hundred and one patients with a first-episode psychosis were included at baseline. At 10-year follow-up 186 were reassessed...
July 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28697856/demographic-and-clinical-correlates-of-substance-use-disorders-in-first-episode-psychosis
#12
Mary F Brunette, Kim T Mueser, Steven Babbin, Piper Meyer-Kalos, Robert Rosenheck, Christoph U Correll, Corrine Cather, Delbert G Robinson, Nina R Schooler, David L Penn, Jean Addington, Sue E Estroff, Jennifer Gottlieb, Shirley M Glynn, Patricia Marcy, James Robinson, John M Kane
BACKGROUND: We assessed the prevalence and correlates of lifetime substance use disorders in people with first episode psychosis using the baseline data from the Recovery After an Initial Schizophrenia Episode (RAISE) Early Treatment Program study. METHODS: Research staff assessed 404 first episode patients at 34 community mental health centers across the United States with the Structured Clinical Interview for DSM-IV for diagnoses of psychotic and substance use disorders...
July 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28692185/an-application-of-functional-near-infrared-spectroscopy-as-supplementary-examination-for-diagnosis-of-clinical-stages-of-psychosis-spectrum
#13
Shinsuke Koike, Satomura Yoshihiro, Shingo Kawasaki, Yukika Nishimura, Akihide Kinoshita, Hanako Sakurada, Mika Yamagishi, Eriko Ichikawa, Jun Matsuoka, Naohiro Okada, Ryu Takizawa, Kiyoto Kasai
AIM: Research efforts aiming at neuroimaging-aided differential diagnosis for psychiatric disorders have been progressing rapidly. A previous multisite study has developed supplementary diagnostic system using functional near-infrared spectroscopy (fNIRS) that can be easily applied to clinical settings. However, few neuroimaging biomarkers have been developed for psychosis spectrum with various clinical stages. METHODS: We employed the fNIRS as a clinical examination device for 143 participants, comprising 47 ultra-high risk (UHR) individuals, 30 patients with first-episode psychosis (FEP), 34 patients with chronic schizophrenia (ChSZ), and 33 healthy controls, who were independent of the previous study...
July 10, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28691278/cognitive-function-treatment-response-to-lithium-and-social-functioning-in-japanese-patients-with-bipolar-disorder
#14
Satoshi Saito, Kumiko Fujii, Yuji Ozeki, Kenichi Ohmori, Gyo Honda, Harunobu Mori, Kazuko Kato, Jinichi Kuroda, Akiko Aoki, Haruhiko Asahi, Hayato Sato, Kazutaka Shimoda, Kazufumi Akiyama
OBJECTIVES: Patients with bipolar disorder often suffer from cognitive impairment that significantly influences their functional outcome. However, it remains unknown whether lithium has a central role in cognition and functional outcome. We examined whether cognition and functional outcome were predicted by demographic and clinical variables, including the response to lithium, in lithium-treated patients with bipolar disorder. METHODS: We evaluated 96 lithium-treated euthymic patients with bipolar disorder and 196 age- and-gender-matched healthy controls, using the Brief Assessment of Cognition in Schizophrenia (BACS)...
July 10, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28689143/glial-cell-line-derived-neurotrophic-factor-gdnf-serum-level-in-women-with-schizophrenia-and-depression-correlation-with-clinical-and-metabolic-parameters
#15
Maria Skibinska, Pawel Kapelski, Joanna Pawlak, Aleksandra Rajewska-Rager, Monika Dmitrzak-Weglarz, Aleksandra Szczepankiewicz, Piotr Czerski, Joanna Twarowska-Hauser
AIM: Neurotrophic factors have been implicated in neuropsychiatric disorders, including schizophrenia and depression. Glial Cell Line-Derived Neurotrophic Factor (GDNF) promotes development, differentiation, and protection of dopaminergic, serotonergic, GABAergic and noradrenergic neurons as well as glial cells in different brain regions. This study examined serum levels of GDNF in schizophrenia and depression and its correlation with metabolic parameters during 8 weeks of treatment. METHODS: Serum GDNF level, fasting serum glucose and lipid profile were measured at baseline and week 8 in 133 women: 55 with schizophrenia, 30 with a first episode depression and 48 healthy controls...
July 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28687870/-genuine-motor-phenomena-in-schizophrenic-psychoses-theoretical-background-and-definition-of-context
#16
D Hirjak, G Northoff, P A Thomann, K M Kubera, R C Wolf
Besides positive and negative symptoms, motor abnormalities have been increasingly recognized as central symptoms of schizophrenia. Recent investigations of antipsychotic-naive first-episode patients with schizophrenia found significantly higher rates of genuine motor abnormalities (GMA) when compared to healthy individuals. The first part of this article introduces the historical and clinical background of GMA in schizophrenia. In the second part the relevance of scientific research and clinical implication of GMA in schizophrenia are discussed...
July 7, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28679479/effectiveness-of-genetically-guided-treatment-in-first-episode-schizophrenia
#17
Marissa Luck, Michael Turner, Mujeeb U Shad
No abstract text is available yet for this article.
July 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28675695/predictors-of-treatment-response-to-psychological-interventions-in-people-at-clinical-high-risk-of-first-episode-psychosis
#18
Helen Wessels, Michael Wagner, Kathrin Kuhr, Julia Berning, Verena Pützfeld, Birgit Janssen, Ronald Bottlender, Kurt Maurer, Hans-Jürgen Möller, Wolfgang Gaebel, Heinz Häfner, Wolfgang Maier, Joachim Klosterkötter, Andreas Bechdolf
AIM: Psychological interventions, such as cognitive behavioural therapy (CBT) and supportive counselling (SC), are used to treat people with schizophrenia and people at clinical high risk (CHR) of psychosis. However, little information is available on predictors of treatment response. This study aims to identify such predictors of psychological interventions in CHR. METHODS: A total of 128 help-seeking CHR outpatients were randomized into two groups-integrated psychological intervention (IPI), including CBT, and SC-for 12 months...
July 4, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28670977/ventricular-volumes-across-stages-of-schizophrenia-and-other-psychoses
#19
Gregor E Berger, Cali F Bartholomeusz, Stephen J Wood, Anthony Ang, Lisa J Phillips, Tina Proffitt, Warrick J Brewer, Deidre J Smith, Barnaby Nelson, Ashleigh Lin, Stefan Borgwardt, Dennis Velakoulis, Alison R Yung, Patrick D McGorry, Christos Pantelis
OBJECTIVE: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. METHODS: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28670828/retraction-statement-long-term-efficacy-and-safety-of-blonanserin-in-patients-with-first-episode-schizophrenia-a-1-year-open-label-trial-by-y-ninomiya-s-miyamoto-t-tenjin-s-ogino-n-miyake-y-kaneda-t-sumiyoshi-and-n-yamaguchi
#20
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