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First-episode schizophrenia

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https://www.readbyqxmd.com/read/29331153/is-cognitive-impairment-associated-with-antipsychotic-dose-and-anticholinergic-equivalent-loads-in-first-episode-psychosis
#1
Alejandro Ballesteros, Ana M Sánchez-Torres, Jose M López-Ilundain, Bibiana Cabrera, Antonio Lobo, Ana M González-Pinto, Covadonga Díaz-Caneja, Iluminada Corripio, Eduard Vieta, Elena de la Serna, Julio Bobes, Judith Usall, Fernando Contreras, Ruth Lorente-Omeñaca, Gisela Mezquida, Miguel Bernardo, Manuel J Cuesta
BACKGROUND: Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have a deleterious effect on cognitive performance remains under debate. We aim to investigate whether anticholinergic loadings and dose of AP drugs in first episode of psychosis (FEP) in advanced phase of remission are associated with cognitive impairment and the differences between premorbid intellectual quotient (IQ) subgroups. METHODS: Two hundred and sixty-six patients participated...
January 14, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29315951/four-way-multimodal-fusion-of-7%C3%A2-t-imaging-data-using-an-mcca-jica-model-in-first-episode-schizophrenia
#2
Kristin K Lottman, David M White, Nina V Kraguljac, Meredith A Reid, Vince D Calhoun, Fabio Catao, Adrienne C Lahti
Acquisition of multimodal brain imaging data for the same subject has become more common leading to a growing interest in determining the intermodal relationships between imaging modalities to further elucidate the pathophysiology of schizophrenia. Multimodal data have previously been individually analyzed and subsequently integrated; however, these analysis techniques lack the ability to examine true modality inter-relationships. The utilization of a multiset canonical correlation and joint independent component analysis (mCCA + jICA) model for data fusion allows shared or distinct abnormalities between modalities to be examined...
January 9, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29314591/relationship-between-metacognitive-beliefs-and-psychosocial-performance-in-at-risk-states-of-psychosis-and-patients-with-first-psychotic-episodes
#3
Martin Brüne, Kim-Alisha Drommelschmidt, Seza Krüger-Özgürdal, Georg Juckel
AIMS: Improving diagnostic batteries to identify individuals at-risk for developing psychotic disorders as early as possible is an ongoing challenge in schizophrenia research. Here, we sought to explore whether metacognition in at-risk of developing psychosis would differ from that of first episode psychosis and unaffected controls and whether dysfunctional metacognitive beliefs would be associated with psychosocial functioning in the clinical groups. METHODS: Twenty-three subjects at-risk of psychosis were compared with a group of 15 first psychotic episode patients and 21 healthy controls with regard to their metacognitive beliefs and psychosocial functioning...
January 4, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29306989/kynurenine-is-correlated-with-il-1%C3%AE-in-plasma-of-schizophrenia-patients
#4
Helena P G Joaquim, Alana C Costa, Wagner F Gattaz, Leda Leme Talib
The etiology of schizophrenia is still unclear. It is well-known that pro-inflammatory cytokines are higher in schizophrenia patients since the first episode psychosis comparing to healthy controls. Inflammatory downstream cascades influence different cellular pathways, like the displacement of the tryptophan (TRP) metabolism to the production of kynurenine (KYN) instead of serotonin, which results in the generation of several neuro and immunoactive metabolites. The aim of this study was to determine TRP, KYN and IL-1β plasma levels in first-onset schizophrenia (n = 28) and healthy controls (n = 30)...
January 6, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29287238/detection-of-early-psychotic-symptoms-validation-of-the-spanish-version-of-the-symptom-onset-in-schizophrenia-sos-inventory
#5
Gisela Mezquida, Bibiana Cabrera, Anabel Martínez-Arán, Eduard Vieta, Miguel Bernardo
The period of subclinical signs that precedes the onset of psychosis is referred to as the prodrome or high-risk mental state. The "Symptom Onset in Schizophrenia (SOS) inventory" is an instrument to characterize and date the initial symptoms of a psychotic illness. The present study aims to provide reliability and validity data for clinical and research use of the Spanish version of the SOS. Thirty-six participants with a first-episode of psychosis meeting DSM-IV criteria for schizophrenia/schizoaffective/schizophreniform disorder were administered the translated SOS and other clinical assessments...
December 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29279246/complement-system-biomarkers-in-first-episode-psychosis
#6
Maja Kopczynska, Wioleta Zelek, Samuel Touchard, Fiona Gaughran, Marta Di Forti, Valeria Mondelli, Robin Murray, Michael C O'Donovan, B Paul Morgan
Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases. Here we explored whether complement dysregulation occurred in first episode psychosis (FEP) and whether this provides a source of biomarkers. Eleven complement analytes (C1q, C3, C4, C5, factor B [FB], terminal complement complex [TCC], factor H [FH], FH-related proteins [FHR125], Properdin, C1 inhibitor [C1inh], soluble complement receptor 1 [CR1]) plus C-reactive protein (CRP) were measured in serum from 136 first episode psychosis (FEP) cases and 42 mentally healthy controls using established in-house or commercial ELISA...
December 23, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29275855/premorbid-iq-subgroups-in-first-episode-non-affective-psychosis-patients-long-term-sex-differences-in-function-and-neurocognition
#7
Rosa Ayesa-Arriola, Esther Setién-Suero, Karl David Neergaard, Àuria Albacete Belzunces, Fernando Contreras, Neeltje E M van Haren, Benedicto Crespo-Facorro
BACKGROUND: Low IQ has been associated with schizophrenia, even to the point of being posited as a possible causal factor for psychosis. However, individuals with normal and high IQ also develop psychotic illnesses. The aim of this study was to characterize premorbid IQ subgroups at first episode of psychosis (FEP). METHODS: The study sample comes from a large epidemiological, 3-year longitudinal, intervention program on psychosis containing individuals living in a catchment area in Spain...
December 21, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29248027/peripheral-levels-of-superoxide-dismutase-and-glutathione-peroxidase-in-youths-in-ultra-high-risk-for-psychosis-a-pilot-study
#8
Maiara Zeni-Graiff, Adiel C Rios, Pawan K Maurya, Lucas B Rizzo, Sumit Sethi, Ana S Yamagata, Rodrigo B Mansur, Pedro M Pan, Elson Asevedo, Graccielle R Cunha, André Zugman, Rodrigo A Bressan, Ary Gadelha, Elisa Brietzke
Introduction Oxidative stress has been documented in chronic schizophrenia and in the first episode of psychosis, but there are very little data on oxidative stress prior to the disease onset. OBJECTIVE: This work aimed to compare serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in young individuals at ultra-high risk (UHR) of developing psychosis with a comparison healthy control group (HC). METHODS: Thirteen UHR subjects and 29 age- and sex-matched healthy controls (HC) were enrolled in this study...
December 17, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29245017/investigating-the-predictors-of-happiness-life-satisfaction-and-success-in-schizophrenia
#9
Sarah Saperia, Susana Da Silva, Ishraq Siddiqui, Krysta McDonald, Ofer Agid, Gary Remington, George Foussias
BACKGROUND: Previous studies have suggested that, despite marked functional impairments, remitted first episode patients with schizophrenia report levels of well-being that are comparable to healthy controls. The aim of the current study was to specifically evaluate self-reported happiness, life satisfaction and success in individuals with schizophrenia beyond their first-episode of psychosis, and to investigate the impact of symptoms and functioning on these subjective experiences. METHODS: Fifty-one schizophrenia patients and 56 matched healthy controls participated in the study...
November 22, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29241838/telomerase-level-increase-is-related-to-n-3-polyunsaturated-fatty-acid-efficacy-in-first-episode-schizophrenia-secondary-outcome-analysis-of-the-offer-randomized-clinical-trial
#10
Tomasz Pawełczyk, Marta Grancow-Grabka, Elżbieta Trafalska, Janusz Szemraj, Natalia Żurner, Agnieszka Pawełczyk
Schizophrenia is associated with shortening of the lifespan mainly due to cardiovascular events, cancer and chronic obstructive pulmonary disease. Both telomere attrition and decrease of telomerase levels were observed in schizophrenia. Polyunsaturated fatty acids (PUFA) influence multiple biochemical mechanisms which are postulated to accelerate telomere shortening and limit the longevity of patients with schizophrenia. Intervention studies based on add-on therapy with n-3 polyunsaturated fatty acids (n-3 PUFA) in patients with schizophrenia did not assess the changes in telomerase levels...
December 11, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29228204/decreased-resting-state-interhemispheric-functional-connectivity-correlated-with-neurocognitive-deficits-in-drug-naive-first-episode-adolescent-onset-schizophrenia
#11
Yi Liu, Yan Zhang, Luxian Lv, Feihu Hu, Renrong Wu, Jingping Zhao, Wenbin Guo
Background: Given that adolescence is a critical epoch in the onset of schizophrenia, studying aberrant brain changes in adolescent-onset schizophrenia (AOS), particularly in patients with drug-naive first-episode schizophrenia, is important to understand the biological mechanism of this disorder. Previous resting-state functional magnetic resonance imaging (fMRI) studies have shown abnormal functional connectivity in separate hemispheres in patients with adult-onset schizophrenia. Our aim to study AOS can provide clues for the early aetiology of schizophrenia...
November 7, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29227896/details-of-attention-and-learning-change-in-first-episode-schizophrenia
#12
Christine Mohn, Anne-Kari Torgalsbøen
Impaired attention and learning functions are common in schizophrenia. The details of this impairment, and how these change across time, are not well known. We aimed to compare the parameters of well-known attention and learning neuropsychological tests in first-episode schizophrenia (FES) patients and healthy controls in a 2-year follow-up period. The performance of 28-25 FES patients and pairwise matched healthy controls on the Continuous Performance Test-Identical Pairs, the revised Hopkins Verbal Learning Test, and the revised Brief Visuospatial Memory Test was compared at baseline and 2 years later...
December 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29227016/patients-with-chronic-bipolar-disorder-exhibit-widespread-increases-in-extracellular-free-water
#13
Carissa Tuozzo, Amanda E Lyall, Ofer Pasternak, Anthony C D James, Timothy J Crow, Marek Kubicki
OBJECTIVES: Bipolar disorder (BP) is a debilitating psychiatric disease that is not well understood. Previous diffusion magnetic resonance imaging (dMRI) studies of BP patients found prominent microstructural white matter (WM) abnormalities of reduced fractional anisotropy (FA). Because FA is a nonspecific measure, relating these abnormalities to a specific pathology is difficult. Here, dMRI specificity was increased by free water (FW) imaging, which allows identification of changes in extracellular space (FW) from neuronal tissue (fractional anisotropy of tissue [FA-t])...
December 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29223800/total-and-differential-white-blood-cell-counts-and-hemodynamic-parameters-in-first-episode-psychosis
#14
Grant Moody, Brian J Miller
There is evidence for blood inflammatory abnormalities in patients with first-episode psychosis (FEP). The monocyte- and neutrophil-to-lymphocyte ratios (MLR; NLR) are markers of inflammation and endothelial dysfunction, and predictors of cardiovascular disease, the leading cause of death in schizophrenia. We investigated relationships between white blood cell (WBC) counts and hemodynamic parameters associated with cardiovascular disease risk in 25 subjects age 18-50 hospitalized for FEP and 44 controls. Subjects had a blood draw, vital signs, and medical history...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29219634/using-molecular-imaging-to-understand-early-schizophrenia-related-psychosis-neurochemistry-a-review-of-human-studies
#15
Christin Schifani, Sina Hafizi, Tania Da Silva, Jeremy Joseph Watts, M Saad Khan, Romina Mizrahi
Schizophrenia is a chronic psychiatric disorder generally preceded by a so-called prodromal phase, which is characterized by attenuated psychotic symptoms. Advances in clinical research have enabled prospective identification of those individuals who are at clinical high risk (CHR) for psychosis, with the power to predict psychosis onset within the near future. Changes in several brain neurochemical systems and molecular mechanisms are implicated in the pathophysiology of schizophrenia and the psychosis spectrum, including the dopaminergic, γ-aminobutyric acid (GABA)-ergic, glutamatergic, endocannabinoid, and immunologic (i...
December 8, 2017: International Review of Psychiatry
https://www.readbyqxmd.com/read/29214289/treated-incidence-of-psychotic-disorders-in-the-multinational-eu-gei-study
#16
Hannah E Jongsma, Charlotte Gayer-Anderson, Antonio Lasalvia, Diego Quattrone, Alice Mulè, Andrei Szöke, Jean-Paul Selten, Caitlin Turner, Celso Arango, Ilaria Tarricone, Domenico Berardi, Andrea Tortelli, Pierre-Michel Llorca, Lieuwe de Haan, Julio Bobes, Miguel Bernardo, Julio Sanjuán, José Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Robin M Murray, Bart P Rutten, Peter B Jones, Jim van Os, Craig Morgan, James B Kirkbride
Importance: Psychotic disorders contribute significantly to the global disease burden, yet the latest international incidence study of psychotic disorders was conducted in the 1980s. Objectives: To estimate the incidence of psychotic disorders using comparable methods across 17 catchment areas in 6 countries and to examine the variance between catchment areas by putative environmental risk factors. Design, Setting, and Participants: An international multisite incidence study (the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions) was conducted from May 1, 2010, to April 1, 2015, among 2774 individuals from England (2 catchment areas), France (3 catchment areas), Italy (3 catchment areas), the Netherlands (2 catchment areas), Spain (6 catchment areas), and Brazil (1 catchment area) with a first episode of nonorganic psychotic disorders (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] codes F20-F33) confirmed by the Operational Criteria Checklist...
December 6, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29209237/decreased-left-putamen-and-thalamus-volume-correlates-with-delusions-in-first-episode-schizophrenia-patients
#17
Xiaojun Huang, Weidan Pu, Xinmin Li, Andrew J Greenshaw, Serdar M Dursun, Zhimin Xue, Haihong Liu, Zhening Liu
Background: Delusional thinking is one of the hallmark symptoms of schizophrenia. However, the underlying neural substrate for delusions in schizophrenia remains unknown. In an attempt to further our understanding of the neural basis of delusions, we explored gray matter deficits and their clinical associations in first-episode schizophrenia patients with and without delusions. Methods: Twenty-four first-episode schizophrenia patients with delusions and 18 without delusions as well as 26 healthy controls (HC) underwent clinical assessment and whole-brain structural imaging which were acquired a 3...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29208422/support-vector-machine-based-classification-of-first-episode-drug-na%C3%A3-ve-schizophrenia-patients-and-healthy-controls-using-structural-mri
#18
Yuan Xiao, Zhihan Yan, Youjin Zhao, Bo Tao, Huaiqiang Sun, Fei Li, Li Yao, Wenjing Zhang, Shah Chandan, Jieke Liu, Qiyong Gong, John A Sweeney, Su Lui
Although regional brain deficits have been demonstrated in schizophrenia patients by structural MRI studies, one important question that remains largely unanswered is whether the complex and subtle deficits revealed by MRI could be used as objective biomarkers to discriminate patients from healthy controls individually. To address this question, a total of 326 right-handed participants were recruited, including 163 drug-naïve first-episode schizophrenia (FES) patients and 163 demographically matched healthy controls...
December 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29206972/nutritional-deficiencies-and-clinical-correlates-in-first-episode-psychosis-a-systematic-review-and-meta-analysis
#19
Joseph Firth, Rebekah Carney, Brendon Stubbs, Scott B Teasdale, Davy Vancampfort, Philip B Ward, Michael Berk, Jerome Sarris
Objective: Diet is increasingly recognized as a potentially modifiable factor influencing the onset and outcomes of psychiatric disorders. Whereas, previous research has shown long-term schizophrenia is associated with various nutritional deficiencies, this meta-analysis aimed to determine the prevalence and extent of nutritional deficits in first-episode psychosis (FEP). Method: A search of electronic databases conducted in July 2017 identified 28 eligible studies, examining blood levels of 6 vitamins and 10 minerals across 2612 individuals: 1221 individuals with FEP and 1391 control subjects...
November 30, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29200569/misidentification-of-wilson-disease-as-schizophrenia-1998-2013-case-report-and-review
#20
Forouzan Elyasi
Wilson's disease (WD) is a neurodegenerative disorder due to copper metabolism. Schizophrenia-like psychosis and delusional disorder are rare forms of psychiatric manifestations of WD. The lack of recognition of these signs and symptoms as being attributable to WD often leads to delays in diagnosis and management. Knowledge about relationship of the psychiatric manifestations to WD can help with the administration of adequate management aimed at both the psychiatric issues and underlying WD. The objectives of this article are to review case reports whose subject is the incorrect diagnosis of schizophrenia or schizophrenia-like syndrome in patients with WD and to detail one case of this mismanagement of the disease...
September 2017: Indian Journal of Psychological Medicine
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