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First-episode psychosis

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https://www.readbyqxmd.com/read/29338891/gray-and-white-matter-changes-and-their-relation-to-illness-trajectory-in-first-episode-psychosis
#1
Alejandro Keymer-Gausset, Anna Alonso-Solís, Iluminada Corripio, Rosa B Sauras-Quetcuti, Edith Pomarol-Clotet, Erick J Canales-Rodriguez, Eva Grasa-Bello, Enric Álvarez, Maria J Portella
Previous works have studied structural brain characteristics in first-episode psychosis (FEP), but few have focused on the relation between brain differences and illness trajectories. The aim of this study is to analyze gray and white matter changes in FEP patients and their relation with one-year clinical outcomes. A sample of 41 FEP patients and 41 healthy controls (HC), matched by age and educational level was scanned with a 3T MRI during the first month of illness onset. One year later, patients were assigned to two illness trajectories (schizophrenia and non-schizophrenia)...
January 12, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29334645/co-morbid-depressive-disorder-is-associated-with-better-neurocognitive-performance-in-first-episode-schizophrenia-spectrum
#2
Sarah E Herniman, Sue M Cotton, Eóin Killackey, Robert Hester, Kelly A Allott
BACKGROUND: Both major depressive disorder (MDD) and first episode schizophrenia spectrum (FES) are associated with significant neurocognitive deficits. However, it remains unclear whether the neurocognitive deficits in individuals with FES are more severe if there is comorbid depressive disorder. The aim of this study was to compare the neurocognitive profiles between those with and without full-threshold depressive disorder in FES. METHOD: This study involved secondary analysis of baseline data from a randomized controlled trial of vocational intervention for young people with first-episode psychosis (N = 82; age range: 15-25 years)...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29334627/testosterone-dhea-and-dhea-s-in-patients-with-schizophrenia-a-systematic-review-and-meta-analysis
#3
REVIEW
Błażej Misiak, Dorota Frydecka, Olga Loska, Ahmed A Moustafa, Jerzy Samochowiec, Justyna Kasznia, Bartłomiej Stańczykiewicz
Neuroactive steroids, including testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) might play an important role in the pathophysiology of schizophrenia. Therefore, we performed a systematic review and meta-analysis of studies comparing the levels of testosterone, DHEA and DHEA-S in patients with schizophrenia and healthy controls. We searched electronic databases from their inception until Oct 29, 2017. Effect size (ES) estimates were calculated as Hedges' g. Data analysis was performed using random-effects models...
January 9, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29334229/physical-and-psychological-health-of-carers-of-young-people-with-first-episode-psychosis
#4
Abner Weng Cheong Poon, Jackie Curtis, Philip Ward, Celia Loneragan, Julia Lappin
OBJECTIVE: Carers of people with psychosis may experience psychological distress and caregiving burden. However, few studies have examined both psychological and physical health of carers of young people with first episode psychosis (FEP). METHOD: A total of 32 young people with FEP and 42 of their carers were recruited from a mental health service. Standardised scales were administered to assess carers' psychological distress and risk for development of Type 2 diabetes...
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29331153/is-cognitive-impairment-associated-with-antipsychotic-dose-and-anticholinergic-equivalent-loads-in-first-episode-psychosis
#5
Alejandro Ballesteros, Ana M Sánchez-Torres, Jose M López-Ilundain, Bibiana Cabrera, Antonio Lobo, Ana M González-Pinto, Covadonga Díaz-Caneja, Iluminada Corripio, Eduard Vieta, Elena de la Serna, Julio Bobes, Judith Usall, Fernando Contreras, Ruth Lorente-Omeñaca, Gisela Mezquida, Miguel Bernardo, Manuel J Cuesta
BACKGROUND: Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have a deleterious effect on cognitive performance remains under debate. We aim to investigate whether anticholinergic loadings and dose of AP drugs in first episode of psychosis (FEP) in advanced phase of remission are associated with cognitive impairment and the differences between premorbid intellectual quotient (IQ) subgroups. METHODS: Two hundred and sixty-six patients participated...
January 14, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29314591/relationship-between-metacognitive-beliefs-and-psychosocial-performance-in-at-risk-states-of-psychosis-and-patients-with-first-psychotic-episodes
#6
Martin Brüne, Kim-Alisha Drommelschmidt, Seza Krüger-Özgürdal, Georg Juckel
AIMS: Improving diagnostic batteries to identify individuals at-risk for developing psychotic disorders as early as possible is an ongoing challenge in schizophrenia research. Here, we sought to explore whether metacognition in at-risk of developing psychosis would differ from that of first episode psychosis and unaffected controls and whether dysfunctional metacognitive beliefs would be associated with psychosocial functioning in the clinical groups. METHODS: Twenty-three subjects at-risk of psychosis were compared with a group of 15 first psychotic episode patients and 21 healthy controls with regard to their metacognitive beliefs and psychosocial functioning...
January 4, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29306989/kynurenine-is-correlated-with-il-1%C3%AE-in-plasma-of-schizophrenia-patients
#7
Helena P G Joaquim, Alana C Costa, Wagner F Gattaz, Leda Leme Talib
The etiology of schizophrenia is still unclear. It is well-known that pro-inflammatory cytokines are higher in schizophrenia patients since the first episode psychosis comparing to healthy controls. Inflammatory downstream cascades influence different cellular pathways, like the displacement of the tryptophan (TRP) metabolism to the production of kynurenine (KYN) instead of serotonin, which results in the generation of several neuro and immunoactive metabolites. The aim of this study was to determine TRP, KYN and IL-1β plasma levels in first-onset schizophrenia (n = 28) and healthy controls (n = 30)...
January 6, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29287238/detection-of-early-psychotic-symptoms-validation-of-the-spanish-version-of-the-symptom-onset-in-schizophrenia-sos-inventory
#8
Gisela Mezquida, Bibiana Cabrera, Anabel Martínez-Arán, Eduard Vieta, Miguel Bernardo
The period of subclinical signs that precedes the onset of psychosis is referred to as the prodrome or high-risk mental state. The "Symptom Onset in Schizophrenia (SOS) inventory" is an instrument to characterize and date the initial symptoms of a psychotic illness. The present study aims to provide reliability and validity data for clinical and research use of the Spanish version of the SOS. Thirty-six participants with a first-episode of psychosis meeting DSM-IV criteria for schizophrenia/schizoaffective/schizophreniform disorder were administered the translated SOS and other clinical assessments...
December 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29282832/hiv-prevalence-among-first-presentation-psychotic-patients
#9
A Laher, N Ariefdien, Y Etlouba
OBJECTIVES: First-episode psychosis is a frequent emergency department (ED) presentation that may potentially be secondary to an underlying life-threatening HIV-related condition. The aim of this study was to determine the prevalence of HIV infection in patients presenting with a first episode of psychosis. METHODS: Medical records of 159 consecutive African, Asian, White and mixed ethnicity patients presenting to a tertiary academic hospital ED with a first episode of psychotic features were prospectively reviewed...
December 28, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29279246/complement-system-biomarkers-in-first-episode-psychosis
#10
Maja Kopczynska, Wioleta Zelek, Samuel Touchard, Fiona Gaughran, Marta Di Forti, Valeria Mondelli, Robin Murray, Michael C O'Donovan, B Paul Morgan
Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases. Here we explored whether complement dysregulation occurred in first episode psychosis (FEP) and whether this provides a source of biomarkers. Eleven complement analytes (C1q, C3, C4, C5, factor B [FB], terminal complement complex [TCC], factor H [FH], FH-related proteins [FHR125], Properdin, C1 inhibitor [C1inh], soluble complement receptor 1 [CR1]) plus C-reactive protein (CRP) were measured in serum from 136 first episode psychosis (FEP) cases and 42 mentally healthy controls using established in-house or commercial ELISA...
December 23, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29275855/premorbid-iq-subgroups-in-first-episode-non-affective-psychosis-patients-long-term-sex-differences-in-function-and-neurocognition
#11
Rosa Ayesa-Arriola, Esther Setién-Suero, Karl David Neergaard, Àuria Albacete Belzunces, Fernando Contreras, Neeltje E M van Haren, Benedicto Crespo-Facorro
BACKGROUND: Low IQ has been associated with schizophrenia, even to the point of being posited as a possible causal factor for psychosis. However, individuals with normal and high IQ also develop psychotic illnesses. The aim of this study was to characterize premorbid IQ subgroups at first episode of psychosis (FEP). METHODS: The study sample comes from a large epidemiological, 3-year longitudinal, intervention program on psychosis containing individuals living in a catchment area in Spain...
December 21, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29251752/-psychosis-in-a-patient-with-prader-willi-syndrome
#12
W Merckx, W Lecot, K Titeca
Prader-Willi syndrome (pws) is a genetic disorder characterised by specific physical and behavioural abnormalities. Recent studies indicate that patients suffering from this syndrome have an increased risk of psychiatric disorders, including psychosis. We describe the development and the psychiatric condition of a 31-year-old patient with pws who had a first psychotic episode at age 14 and subsequently experienced a highly variable course of recovery and relapse.
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29250962/pathways-to-functional-outcomes-following-a-first-episode-of-psychosis-the-roles-of-premorbid-adjustment-verbal-memory-and-symptom-remission
#13
Gerald Jordan, Franz Veru, Martin Lepage, Ridha Joober, Ashok Malla, Srividya N Iyer
OBJECTIVE: Most studies have investigated either the singular or relative contributions of premorbid adjustment, verbal memory and symptom remission to functional outcomes in first-episode psychosis. Fewer studies have examined the pathways of these factors in impacting functioning. Our study addresses this gap. The objective was to determine whether the relationship between premorbid adjustment and functional outcomes was mediated by verbal memory and symptom remission. METHOD: A total of 334 first-episode psychosis participants (aged 14-35 years) were assessed on premorbid adjustment, verbal memory upon entry, and positive and negative symptom remission and functioning at multiple time points over a 2-year follow-up...
December 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29249808/brain-structure-in-women-at-risk-of-postpartum-psychosis-an-mri-study
#14
Montserrat Fusté, Astrid Pauls, Amanda Worker, Antje A T S Reinders, Andrew Simmons, Steven C R Williams, Josep M Haro, Kate Hazelgrove, Susan Pawlby, Susan Conroy, Costanza Vecchio, Gertrude Seneviratne, Carmine M Pariante, Mitul A Mehta, Paola Dazzan
Postpartum psychosis (PP) is the most severe psychiatric disorder associated with childbirth. The risk of PP is very high in women with a history of bipolar affective disorder or schizoaffective disorder. However, the neurobiological basis of PP remains poorly understood and no study has evaluated brain structure in women at risk of, or with, PP. We performed a cross-sectional study of 256 women at risk of PP and 21 healthy controls (HC) in the same postpartum period. Among women at risk, 11 who developed a recent episode of PP (PPE) (n = 2 with lifetime bipolar disorder; n = 9 psychotic disorder not otherwise specified) and 15 at risk women who did not develop an episode of PP (NPPE) (n = 10 with lifetime bipolar disorder; n = 1 with schizoaffective disorder; n = 1 with a history of PP in first-degree family member; n = 3 with previous PP)...
December 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29249448/seizure-activity-and-individual-vulnerability-on-first-episode-interictal-psychosis-in-epilepsy
#15
Naoto Adachi, Nozomi Akanuma, Peter Fenwick, Masumi Ito, Mitsutoshi Okazaki, Shiro Ishida, Masanori Sekimoto, Masaaki Kato, Teiichi Onuma
OBJECTIVE: Despite a theoretical consensus that interictal psychosis (IIP) is related to various epilepsy-related factors, the impact of seizure activity on development of IIP remains inconclusive. This is the first controlled study using quantitative seizure-activity measures at the onset of IIP. METHODS: One hundred and eighty-one patients with epilepsy who exhibited first-episode IIP (IIP group) and 427 patients with epilepsy without psychotic episodes (control group) were enrolled...
December 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29248027/peripheral-levels-of-superoxide-dismutase-and-glutathione-peroxidase-in-youths-in-ultra-high-risk-for-psychosis-a-pilot-study
#16
Maiara Zeni-Graiff, Adiel C Rios, Pawan K Maurya, Lucas B Rizzo, Sumit Sethi, Ana S Yamagata, Rodrigo B Mansur, Pedro M Pan, Elson Asevedo, Graccielle R Cunha, André Zugman, Rodrigo A Bressan, Ary Gadelha, Elisa Brietzke
Introduction Oxidative stress has been documented in chronic schizophrenia and in the first episode of psychosis, but there are very little data on oxidative stress prior to the disease onset. OBJECTIVE: This work aimed to compare serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in young individuals at ultra-high risk (UHR) of developing psychosis with a comparison healthy control group (HC). METHODS: Thirteen UHR subjects and 29 age- and sex-matched healthy controls (HC) were enrolled in this study...
December 17, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29245017/investigating-the-predictors-of-happiness-life-satisfaction-and-success-in-schizophrenia
#17
Sarah Saperia, Susana Da Silva, Ishraq Siddiqui, Krysta McDonald, Ofer Agid, Gary Remington, George Foussias
BACKGROUND: Previous studies have suggested that, despite marked functional impairments, remitted first episode patients with schizophrenia report levels of well-being that are comparable to healthy controls. The aim of the current study was to specifically evaluate self-reported happiness, life satisfaction and success in individuals with schizophrenia beyond their first-episode of psychosis, and to investigate the impact of symptoms and functioning on these subjective experiences. METHODS: Fifty-one schizophrenia patients and 56 matched healthy controls participated in the study...
November 22, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29242001/social-functioning-in-patients-with-first-episode-psychosis
#18
Nikolai Albert, Jamal Uddin, Merete Nordentoft
No abstract text is available yet for this article.
December 11, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/29242000/social-recovery-therapy-in-combination-with-early-intervention-services-for-enhancement-of-social-recovery-in-patients-with-first-episode-psychosis-supereden3-a-single-blind-randomised-controlled-trial
#19
David Fowler, Jo Hodgekins, Paul French, Max Marshall, Nick Freemantle, Paul McCrone, Linda Everard, Anna Lavis, Peter B Jones, Tim Amos, Swaran Singh, Vimal Sharma, Max Birchwood
BACKGROUND: Provision of early intervention services has increased the rate of social recovery in patients with first-episode psychosis; however, many individuals have continuing severe and persistent problems with social functioning. We aimed to assess the efficacy of early intervention services augmented with social recovery therapy in patients with first-episode psychosis. The primary hypothesis was that social recovery therapy plus early intervention services would lead to improvements in social recovery...
December 11, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/29235890/low-density-lipoprotein-cholesterol-and-suicidal-behaviour-in-a-large-sample-of-first-episode-psychosis-patients
#20
Rosa Ayesa-Arriola, Manuel Canal Rivero, Manuel Delgado-Alvarado, Esther Setién-Suero, Jana González-Gómez, Javier Labad, Anthony S David, Benedicto Crespo-Facorro
OBJECTIVES: Our aims were to confirm the relationship between lipid and lipoprotein concentrations and suicidal behaviour in first episode psychosis (FEP) patients. METHODS: Suicidal behaviour was explored in a large FEP sample (N = 383). Baseline lipid profile was compared between those who attempted or completed suicide and those who not presented suicidal behaviour. RESULTS: Low-density lipoprotein cholesterol (LDL-c) (OR = 0.99, 95% CI= 0...
December 13, 2017: World Journal of Biological Psychiatry
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