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First-episode psychosis

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https://www.readbyqxmd.com/read/28925317/dopamine-supersensitivity-psychosis-in-schizophrenia-concepts-and-implications-in-clinical-practice
#1
Yusuke Nakata, Nobuhisa Kanahara, Masaomi Iyo
Dopamine supersensitivity psychosis (DSP) is observed in patients with schizophrenia under antipsychotic treatment, and it is characterized by rebound psychosis, an uncontrollable psychotic episode following a stable state and tardive dyskinesia. DSP, first described in patients taking typical antipsychotics in the late 1970s, sometimes appears even in patients who are treated with current atypical antipsychotics. It was recently demonstrated that DSP can have a negative impact on the long-term prognosis of schizophrenia patients and that DSP could be involved in the etiology of some cases of treatment-resistant schizophrenia...
September 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28922588/persistent-negative-symptoms-in-first-episode-psychosis-early-cognitive-and-social-functioning-correlates-and-differences-between-early-and-adult-onset
#2
Olga Puig, Immaculada Baeza, Elena de la Serna, Bibiana Cabrera, Gisela Mezquida, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Mara Parellada, Iluminada Corripio, Eduard Vieta, Julio Bobes, Judith Usall, Fernando Contreras, Manuel J Cuesta, Miquel Bernardo, Josefina Castro-Fornieles, The PEPs Group
OBJECTIVE: To characterize the early cognitive and social functioning characteristics of a sample of first-episode psychosis patients with and without persistent negative symptoms (PNS) and to examine the prevalence and cognitive and functional correlates of PNS in patients with early-onset versus adult-onset first-episode psychosis. METHODS: Participants were 235 patients with first-episode psychosis (51 early-onset, 184 adult-onset) and 240 healthy controls from a multicenter longitudinal study (recruited between 2009 and 2011)...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28920570/brain-relevant-antibodies-in-first-episode-psychosis-a-matched-case-control-study
#3
Fiona Gaughran, John Lally, Katherine Beck, Ruaidhri McCormack, Poonam Gardner-Sood, Ester Coutinho, Leslie Jacobson, Bethan Lang, Ricardo Sainz-Fuertes, Evangelos Papanastasiou, Marta Di Forti, Tim Nicholson, Angela Vincent, Robin M Murray
BACKGROUND: There has been much recent excitement about the possibility that some cases of psychosis may be wholly due to brain-reactive antibodies, with antibodies to N-methyl-D-aspartate receptor (NMDAR) and the voltage-gated potassium channel (VGKC)-complex reported in a few patients with first-episode psychosis (FEP). METHODS: Participants were recruited from psychiatric services in South London, UK, from 2009 to 2011 as part of the Genetics and Psychosis study...
September 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28918863/more-haste-less-speed-a-meta-analysis-of-thinking-latencies-during-planning-in-people-with-psychosis
#4
REVIEW
Andrew J Watson, Eileen M Joyce, Andrew J B Fugard, Verity C Leeson, Thomas R E Barnes, Vyv Huddy
Cognitive impairment is a core feature of psychosis, with slowed processing speed thought to be a prominent impairment in schizophrenia and first-episode psychosis. However, findings from the Stockings of Cambridge (SOC) planning task suggest changes in processing speed associated with the illness may include faster responses in early stages of planning, though findings are inconsistent. This review uses meta-analytic methods to assess thinking times in psychosis across the available literature. Studies were identified by searching PubMed, Web of Science and Google Scholar...
September 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28910597/predictors-of-change-in-social-networks-support-and-satisfaction-following-a-first-episode-psychosis-a-cohort-study
#5
Laoise Renwick, Liz Owens, John Lyne, Brian O'Donoghue, Eric Roche, Jonathan Drennan, Ann Sheridan, Mark Pilling, Eadbhard O'Callaghan, Mary Clarke
BACKGROUND: Diminished social networks are common in psychosis but few studies have measured these comprehensively and prospectively to determine how networks and support evolve during the early phase. There is little information regarding perceived support in the early phase of illness. The aim of this study was to describe social support, networks and perceived satisfaction, explore the clinical correlates of these outcomes and examine whether phases of untreated psychosis are linked with social network variables to determine potential opportunities for intervention...
August 30, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28898807/social-functioning-in-individuals-with-first-episode-psychosis-one-year-follow-up-study
#6
Vijaya Raghavan, Mangala Ramamurthy, Thara Rangaswamy
BACKGROUND: Improvement in social functioning is important for recovery in first episode psychosis (FEP). METHODOLOGY: 51 individuals diagnosed with first episode psychosis were assessed for social functioning at baseline and one year follow-up. RESULTS: Significant improvement was seen in certain domains of social functioning measured by LSP scale such as communication and non-turbulence while no significant changes were observed in self-care and social contact...
September 6, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28890132/motor-abnormalities-in-first-episode-psychosis-patients-and-long-term-psychosocial-functioning
#7
Manuel J Cuesta, Elena García de Jalón, M Sol Campos, Lucía Moreno-Izco, Ruth Lorente-Omeñaca, Ana M Sánchez-Torres, Víctor Peralta
Motor abnormalities (MAs) are highly prevalent in patients with first-episode psychosis both before any exposure and after treatment with antipsychotic drugs. However, the extent to which these abnormalities have predictive value for long-term psychosocial functioning is unknown. One hundred antipsychotic-naive first-episode psychosis (FEP) patients underwent extensive motor evaluation including catatonic, parkinsonism, dyskinesia, akathisia and neurological soft signs. Patients were assessed at naïve state and 6months later...
September 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28888361/increased-platelet-glycogen-sysnthase-kinase-3beta-in-first-episode-psychosis
#8
Helena P G Joaquim, Marcus V Zanetti, Mauricio H Serpa, Martinus T Van de Bilt, Paulo C Sallet, Tiffany M Chaim, Geraldo F Busatto, Wagner F Gattaz, Leda L Talib
Past studies have linked intracellular pathways related to psychotic disorders to the GSK3B enzyme. This study aimed to investigate GSK3B protein expression and phosphorylation in drug-naïve first-episode psychosis patients (n=43) at baseline and following symptom remission, and in healthy controls (n=77). At baseline GSK3B total level was higher in patients (p<0.001). In schizophrenia spectrum patients (n=25) GSK3B total and phosphorylated levels were higher than in controls and patients with other non-affective psychotic disorders (n=18) (p<0...
September 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28888358/prediction-of-self-stigma-in-early-psychosis-3-year-follow-up-of-the-randomized-controlled-trial-on-extended-early-intervention
#9
Ryan Wui Hang Ho, Wing Chung Chang, Vivian Wing Yan Kwong, Emily Sin Kei Lau, Gloria Hoi Kei Chan, Olivia Tsz Ting Jim, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Eric Yu Hai Chen
BACKGROUND: Self-stigma represents a major barrier to recovery in people with psychotic disorders but is understudied in early illness stage. Longitudinal investigation of prediction for self-stigma is scarce and none is conducted in early psychosis. We aimed to prospectively examine baseline predictors of self-stigma in early psychosis patients in the context of a 3-year follow-up of a randomized-controlled trial (RCT) comparing 1-year extension of early intervention (EI) with step-down psychiatric care for first-episode psychosis (FEP)...
September 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28886671/canadian-schizophrenia-guidelines-schizophrenia-and-other-psychotic-disorders-with-coexisting-substance-use-disorders
#10
David Crockford, Donald Addington
OBJECTIVE: Persons with schizophrenia and other psychotic disorders frequently have coexisting substance use disorders that require modifications to treatment approaches for best outcomes. The objectives of this review were to identify evidence-based practices best practices that improve outcomes for individuals with schizophrenia and substance used disorders. METHOD: We reviewed guidelines that were published in the last 5 years and that included systematic reviews or meta-analyses...
September 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28886449/development-and-validation-of-the-questionnaire-of-stressful-life-events-qsle
#11
Anna Butjosa, Juana Gómez-Benito, Inez Myin-Germeys, Ana Barajas, Iris Baños, Judith Usall, Norma Grau, Luis Granell, Andrea Sola, Janina Carlson, Montserrat Dolz, Bernardo Sánchez, Josep Maria Haro, Susana Ochoa
Stressful life events (SLEs) are important indicators prior to the onset of first-episode psychosis (FEP). Although there are well-validated interviews and self-reports for assessing SLE on proximate events, unfortunately there are no instruments to assess SLE covering an entire lifetime. This study includes detailed specific items of childhood, adolescence, and adulthood focused on the presence of SLE, emotional impact (stressfulness), and the age at which the event occurred. Our research describes 2 studies designed to develop and validate a new scale to assess SLE: the Questionnaire of Stressful Life Events (QSLE)...
August 31, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28880494/clinical-psychopathology-in-youth-at-familial-high-risk-for-psychosis
#12
Jai L Shah, Neeraj Tandon, Debra M Montrose, Diana Mermon, Shaun M Eack, Jean Miewald, Matcheri S Keshavan
AIM: While the course of psychopathology has been explored from an index mental health diagnosis onwards, there are few detailed, prospective studies of the occurrence of clinical psychopathology in youth with familial risk for severe mental illnesses such as psychosis. We sought to describe the appearance of Axis I psychopathology in a unique sample of adolescents with a family history of schizophrenia (FHR). METHODS: One hundred and sixty two first- and second-degree relatives (mean age 15...
September 7, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28869097/cbt-in-the-prevention-of-psychosis-and-other-severe-mental-disorders-in-patients-with-an-at-risk-mental-state-a-review-and-proposed-next-steps
#13
Mark van der Gaag, David van den Berg, Helga Ising
Patients with an 'At risk mental state' (ARMS) for developing psychosis can be treated successfully with CBT to postpone and prevent the transition to a first psychotic episode. A characteristic of individuals that meet ARMS criteria is that they are still open for multiple explanations for extraordinary experiences. CBT aims to normalize extraordinary experiences with education and to prevent delusional explanations. The treatment is not only effective, but also cost-saving in averting psychosis as well as in reducing disability adjusted life years at 18- and 48-month follow-up...
August 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28867407/childhood-adversities-and-clinical-symptomatology-in-first-episode-psychosis
#14
Maija Lindgren, Teemu Mäntylä, Eva Rikandi, Minna Torniainen-Holm, Isabel Morales-Muñoz, Tuula Kieseppä, Outi Mantere, Jaana Suvisaari
In addition to severe traumatic experiences, milder, more common childhood adversities reflecting psychosocial burden may also be common in people with psychotic disorders and have an effect on symptomatology and functioning. We explored eleven negative childhood experiences and their influence on clinical symptoms among young adults with first-episode psychosis (FEP, n = 75) and matched population controls (n = 51). Individuals with FEP reported more adversities than controls. Specifically serious conflicts within the family, bullying at school, maternal mental health problems, and one's own and parents' serious illness during childhood were experienced by the patients more often than by controls...
August 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28864750/do-antipsychotic-drugs-lose-their-efficacy-for-relapse-prevention-over-time
#15
EDITORIAL
Stefan Leucht, John M Davis
There is a debate about long-term treatment of schizophrenia with antipsychotic drugs, with some experts suggesting that these drugs should be discontinued. In this issue, Takeuchi et al demonstrated by a meta-analysis of 11 trials that antipsychotic drugs maintained their efficacy for relapse prevention for 1 year, whereas patients on placebo kept getting worse. We consider these findings in the light of the current discussion about possible dose-related brain volume loss, supersensitivity psychosis, the high variability of results in long-term follow-up studies and recent approaches to discontinue antipsychotics in patients with a first-episode...
September 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28864280/commentary-cultural-factors-in-first-episode-psychosis-treatment-engagement
#16
Emily Kline, Latoya Thomas
Specialized First Episode Psychosis (FEP) services have been conceptualized in part around the issue of engagement. Creating treatment that is easier to access, with more frequent contacts, assertive outreach to clients between appointments, and an explicit youth-oriented culture could make services more attractive to those most in need of care. However, engagement has remained a mostly fuzzy, peripheral construct rather than the object of study in itself. As we recognize the importance of treatment engagement, we must prepare to address it more rigorously within psychosis and schizophrenia research...
August 29, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28859587/first-episode-psychosis-and-the-criminal-justice-system-using-a-sequential-intercept-framework-to-highlight-risks-and-opportunities
#17
Tobias Wasser, Jessica Pollard, Deborah Fisk, Vinod Srihari
In first-episode psychosis there is a heightened risk of aggression and subsequent criminal justice involvement. This column reviews the evidence pointing to these heightened risks and highlights opportunities, using a sequential intercept model, for collaboration between mental health services and existing diversionary programs, particularly for patients whose behavior has already brought them to the attention of the criminal justice system. Coordinating efforts in these areas across criminal justice and clinical spheres can decrease the caseload burden on the criminal justice system and optimize clinical and legal outcomes for this population...
September 1, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28858639/childhood-trauma-and-psychosis-beyond-the-association
#18
Grégoire Baudin, Andrei Szoke, Jean-Romain Richard, Antoine Pelissolo, Marion Leboyer, Franck Schürhoff
Childhood traumas have been extensively associated with the development of psychotic disorders. However, our understanding of processes underlying this relationship remains poor. In order to address this issue, we examined which specific aspects of childhood trauma are significantly associated with a first episode of psychosis. 109 patients with first episode of psychosis and 145 controls representative from general population were recruited in three centers in France. Child experiences of care and abuses allowed obtaining information about types of childhood trauma, age at first exposure, identity of perpetrator, and social support...
August 28, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28858430/social-network-confidants-duration-of-untreated-psychosis-and-cannabis-use-in-people-with-first-episode-psychosis-an-exploratory-study
#19
Giuseppe Carrà, Claudia Battaglia, Mark Hinton, Luke Sheridan Rains, Cristina Crocamo, Sonia Johnson
AIM: Reduced social network (SN) might be associated with a longer duration of untreated psychosis (DUP) in people with first episode psychosis (FEP). We aimed at exploring the specific role of SN confidants on DUP, taking into account cannabis misuse, which is known to influence DUP and might be associated with social functioning. METHODS: People with FEP recently referred to an inner London Early Intervention Service were assessed with standardized instruments exploring SN characteristics, DUP and cannabis misuse...
August 31, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28857488/preliminary-study-of-higher-order-language-and-extralinguistic-impairments-in-individuals-with-high-clinical-risk-of-psychosis-and-first-episode-of-schizophrenia
#20
Agnieszka Pawełczyk, Magdalena Kotlicka-Antczak, Emila Łojek, Tomasz Pawełczyk
AIM: Higher-order language functions are associated with understanding indirect speech acts, lexical-semantic processes, the understanding and production of prosody, discourse production and comprehension. Only a few studies imply that language abnormalities may be present in individuals at ultra-high risk for psychosis (UHR) and first-episode of schizophrenia (FE). The purpose of this study was to test the presence of higher-order language dysfunctions in UHR and FE subjects using a standardized comprehensive test battery...
August 31, 2017: Early Intervention in Psychiatry
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