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First-episode psychosis

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https://www.readbyqxmd.com/read/28531646/lifetime-presence-of-psychotic-symptoms-in-bipolar-disorder-is-associated-with-less-favorable-socio-demographic-and-certain-clinical-features
#1
Bernardo Dell'Osso, Giulia Camuri, Laura Cremaschi, Cristina Dobrea, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
BACKGROUND: The presence of psychotic symptoms in bipolar disorder (BD) is considered a feature of higher severity of illness and, in particular, of manic episodes in bipolar I disorder (BD I). However, the possibility to apply the "with psychotic features" specifier to major depressive episodes in either bipolar II disorder (BD II) or BD I highlights the need for additional research in this area. METHODS: The present study assessed the lifetime presence of psychotic symptoms and related socio-demographic and clinical features in a large sample of BD patients (N=360), with (BDPs, N=207) and without a lifetime history of psychosis (BDNPs, N=153)...
April 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28526280/an-overview-of-medical-risk-factors-for-childhood-psychosis-implications-for-research-and-treatment
#2
REVIEW
Marianna Giannitelli, Angèle Consoli, Marie Raffin, Renaud Jardri, Douglas F Levinson, David Cohen, Claudine Laurent-Levinson
OBJECTIVE: Psychotic disorders in childhood and early adolescence often progress to chronic schizophrenia, but in many cases there are diagnosable medical and genetic causes or risk factors. We reviewed our clinical experience and the relevant literature to identify these factors and to define their clinical features, appropriate work-up and treatment. METHOD: We reviewed the results of comprehensive medical evaluations of 160 psychotic children and adolescents in our center...
May 16, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28524542/negative-schemata-about-the-self-and-others-and-paranoid-ideation-in-at-risk-states-and-those-with-persisting-positive-symptoms
#3
Hendrik Müller, Walter de Millas, Wolfgang Gaebel, Jutta Herrlich, Alkomiet Hasan, Birgit Janssen, Georg Juckel, Anne Karow, Tilo Kircher, Stefanie Kiszkenow-Bäker, Stefan Klingberg, Joachim Klosterkötter, Seza Krüger-Özgürdal, Martin Lambert, Marion Lautenschlager, Wolfgang Maier, Tanja Maria Michel, Stefanie Mehl, Bernhard W Müller, Verena Pützfeld, Franziska Rausch, Michael Riedel, Gudrun Sartory, Frank Schneider, Michael Wagner, Georg Wiedemann, Andreas Wittorf, Thomas Wobrock, Wolfgang Wölwer, Mathias Zink, Andreas Bechdolf
BACKGROUND: The objective of this study is to test the conflicting theories concerning the association of negative self and other schemata and paranoid ideation. METHODS: A risk-based approach, including risk stratification, is used to gain insight into the association of the negative self and other schemata that may be shared by individuals or differentiate between individuals at clinical high risk (CHR) for a first-episode psychosis and those with full-blown psychosis...
May 19, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28524541/-worried-about-relapse-family-members-experiences-and-perspectives-of-relapse-in-first-episode-psychosis
#4
Shalini Lal, Ashok Malla, Gina Marandola, Joanie Thériault, Phil Tibbo, Rahul Manchanda, Richard Williams, Ridha Joober, Nicola Banks
BACKGROUND: The purpose of this study was to gain an in-depth understanding on the subject of relapse from the perspectives of family members of young people receiving services for a first-episode psychosis (FEP). METHODS: A qualitative descriptive approach, using focus group methods, was used to elicit experiences, understandings, and knowledge of relapse in FEP. Family members were recruited from 4 specialized early intervention programmes for psychosis in Canada...
May 19, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28521146/effect-of-continued-cannabis-use-on-medication-adherence-in-the-first-two-years-following-onset-of-psychosis
#5
Tabea Schoeler, Natalia Petros, Marta Di Forti, Ewa Klamerus, Enrico Foglia, Robin Murray, Sagnik Bhattacharyya
Uncertainty exists whether the use of non-prescription psychoactive substances following onset of a first episode of psychosis (FEP), in particular cannabis use, affects medication adherence. Data from FEP patients (N=233) obtained through prospective assessments measured medication adherence and pattern of cannabis and other substance use in the first two years following onset of psychosis. Multiple logistic regression analyses were employed to compare the different substance use groups with regard to risk of medication non-adherence, while controlling for confounders...
May 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28521056/ethnic-minority-status-age-at-immigration-and-psychosis-risk-in-rural-environments-evidence-from-the-sepea-study
#6
James B Kirkbride, Yasir Hameed, Konstantinos Ioannidis, Gayatri Ankireddypalli, Carolyn M Crane, Mukhtar Nasir, Nikolett Kabacs, Antonio Metastasio, Oliver Jenkins, Ashkan Espandian, Styliani Spyridi, Danica Ralevic, Suneetha Siddabattuni, Ben Walden, Adewale Adeoye, Jesus Perez, Peter B Jones
Objective: Several ethnic minority groups experience elevated rates of first-episode psychosis (FEP), but most studies have been conducted in urban settings. We investigated whether incidence varied by ethnicity, generation status, and age-at-immigration in a diverse, mixed rural, and urban setting. Method: We identified 687 people, 16-35 years, with an ICD-10 diagnosis of FEP, presenting to Early Intervention Psychosis services in the East of England over 2 million person-years...
May 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28517041/modifying-illness-beliefs-in-recent-onset-psychosis-carers-evaluating-the-impact-of-a-cognitively-focused-brief-group-intervention-in-a-routine-service
#7
Juliana Onwumere, Naomi Glover, Sarah Whittaker, Shireen Rahim, Lai Chu Man, Gareth James, Sanna Khan, Roya Afsharzadegan, Saal Seneviratne, Raythe Harvey, Anna Georgiades, David Raune
AIMS: At first-episode psychosis (FEP), many patients will be routed within familial networks and supported by informal carers who are predominately close family members such as parents. Carer burden, distress and poorer coping styles are associated with different illness beliefs. The current study sought to examine the impact and acceptability of a 3 session, cognitively informed, group intervention targeting illness beliefs previously linked to distress and poorer caregiving experiences in FEP carers...
May 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28516734/does-co-occurring-borderline-personality-disorder-influence-acute-phase-treatment-for-first-episode-psychosis
#8
Shona M Francey, Martina Jovev, Christina Phassouliotis, Sue M Cotton, Andrew M Chanen
BACKGROUND: This aims of this study were: (1) to determine the prevalence of co-occurring borderline personality disorder (BPD) in a first-episode psychosis (FEP) sample; (2) to determine differences between patients with and without BPD on demographics, comorbidities and clinical risks and other variables; and (3) to examine whether BPD comorbidity influenced treatment received by patients for FEP during their first 3 months after service entry to a specialist early psychosis service...
May 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28506707/complex-mismatch-negativity-to-tone-pair-deviants-in-long-term-schizophrenia-and-in-the-first-episode-schizophrenia-spectrum
#9
Dean F Salisbury, Alexis G McCathern, Brian A Coffman, Timothy K Murphy, Sarah M Haigh
Mismatch negativity (MMN) is an event-related potential to stimulus change. MMN to infrequent deviant tones that differs in a simple physical parameter from repetitive standard tones is reduced in patients with long-term schizophrenia (Sz; d=~1). However, this simple MMN is not uniformly reduced at the first-episode of schizophrenia-spectrum psychosis (FESz; d<0.1 for pitch; <0.4 for duration). Deviant stimuli that violate pattern rules also evoke MMN. This complex MMN is evoked by deviations in the relation of sounds to each other...
May 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28490910/optimizing-psychosocial-interventions-in-first-episode-psychosis-current-perspectives-and-future-directions
#10
REVIEW
Nicholas Jk Breitborde, Aubrey M Moe, Arielle Ered, Lauren M Ellman, Emily K Bell
Psychotic-spectrum disorders such as schizophrenia, schizoaffective disorder, and bipolar disorder with psychotic features are devastating illnesses accompanied by high levels of morbidity and mortality. Growing evidence suggests that outcomes for individuals with psychotic-spectrum disorders can be meaningfully improved by increasing the quality of mental health care provided to these individuals and reducing the delay between the first onset of psychotic symptoms and the receipt of adequate psychiatric care...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28485998/barriers-to-seeking-early-psychiatric-treatment-amongst-first-episode-psychosis-patients-a-qualitative-study
#11
Abd Alhadi Hasan, Mahmoud Musleh
AIMS: The aim of this study was to explore the family members' determinant of the delay in seeking psychiatric care to patients diagnosed with psychosis. METHODS: Qualitative semi-structured interviews were carried out with twenty-seven family members of patients with psychosis at psychiatric outpatient clinics in Amman, Jordan. RESULTS: The findings revealed that perceived stigma and fears about being labelled are the main barriers to requesting early psychiatric health care...
May 9, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28484349/one-year-follow-up-of-patients-with-a-diagnosis-of-first-episode-psychosis
#12
Atena Enderami, Fatemeh Sheikh Monesi, Mehran Zarghami
INTRODUCTION: Early diagnosis of symptoms related to psychotic disorders causes hyper responsiveness, recurrence reduction and quality of life improvement. The aim of this study was one-year follow-up of the clinical course and outcomes of hospitalized patients with first episode psychotic disorders and detection of factors affecting consequences. METHODS: This longitudinal descriptive study was conducted during 2012 to 2013 on hospitalized patients at Zare Hospital in Sari, Iran, with any psychotic symptoms and with diagnosis of first episode psychosis...
March 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28483103/cytokines-cortisol-and-igf-1-in-first-episode-psychosis-and-ultra-high-risk-males-evidence-for-tnf-%C3%AE-ifn-%C3%AE-%C3%AE-nf-%C3%AE-il-4-deviation
#13
Evangelos Karanikas, Stefanos Manganaris, Evangelos Ntouros, Georgios Floros, Diomidis Antoniadis, Georgios Garyfallos
The aim of the study was to determine circulating cytokines, cortisol and Insulin-like Growth Factor (IGF)-1, known for their involvement in inflammation, in male patients with First Episode Psychosis (FEP) and subjects at Ultra High Risk (UHR) for Psychosis. The FEP group presented increased pro-inflammatory cytokines (TNF-α, IFN-γ, ΤNF-β) as well as increased anti-inflammatory cytokine (IL-4) compared with Healthy Controls (HC). The UHR group showed increased IL-4 against HC. In contrast, none of the groups did show deviation from normality in either cortisol or IGF-1 levels...
April 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28482196/auditory-and-non-auditory-hallucinations-in-first-episode-psychosis-differential-associations-with-diverse-clinical-features
#14
Chiara Galletti, Enrico Paolini, Alfonso Tortorella, Michael T Compton
Data from 247 first-episode psychosis patients were used to explore associations between types of hallucinations and nine diverse clinical characteristics. Psychopathology was rated using the Scale for the Assessment of Positive Symptoms and Scale for the Assessment of Negative Symptoms (SANS). Childhood adversity was assessed with seven instruments; family history with an adapted version of the Family Interview for Genetic Studies; age at onset of psychosis and duration of untreated psychosis (DUP) with the Symptom Onset in Schizophrenia inventory; and insight with the Birchwood Insight Scale...
April 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28477070/rates-and-predictors-of-18-months-remission-in-an-epidemiological-cohort-of-661-patients-with-first-episode-psychosis
#15
Philippe Conus, Sue Cotton, Benno G Schimmelmann, Patrick D McGorry, Martin Lambert
OBJECTIVES: Most first episode psychosis (FEP) outcome studies are based on patient samples enrolled through an informed consent procedure, which may induce important biases. Our aim was to study the 18-month outcome of FEP in an epidemiological sample of patients treated at the Early Psychosis Prevention and Intervention Centre (EPPIC). METHODS: The files of 661 FEP patients treated for up to 18 months between 1998 and 2000 were assessed. Symptomatic remission was defined as receiving a score ≤3 on the Clinical Global Impressions (CGI) scales, and functional remission as concurrent fulfillment of occupation/employment and independent living...
May 5, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28473319/clinical-utility-of-magnetic-resonance-imaging-in-first-episode-psychosis
#16
Irina Falkenberg, Stefania Benetti, Marie Raffin, Phillipe Wuyts, William Pettersson-Yeo, Paola Dazzan, Kevin D Morgan, Robin M Murray, Tiago Reis Marques, Anthony S David, Jozef Jarosz, Andrew Simmons, Steve Williams, Philip McGuire
BackgroundThere is no consensus as to whether magnetic resonance imaging (MRI) should be used as part of the initial clinical evaluation of patients with first-episode psychosis (FEP).Aims(a) To assess the logistical feasibility of routine MRI; (b) to define the clinical significance of radiological abnormalities in patients with FEP.MethodRadiological reports from MRI scans of two FEP samples were reviewed; one comprised 108 patients and 98 healthy controls recruited to a research study and the other comprised 241 patients scanned at initial clinical presentation plus 66 healthy controls...
May 4, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28466380/differences-of-temporal-dynamics-and-signal-complexity-of-gamma-band-oscillations-in-first-episode-psychosis-during-a-working-memory-task
#17
Pascal Missonnier, Logos Curtis, Joseph Ventura, François R Herrmann, Marco C G Merlo
Gamma band oscillations participate in the temporal binding needed to synchronize cortical networks, involved in early sensory and short term memory processes. In earlier studies, alterations of these neurophysiological parameters have been found in psychotic disorders. To date no study has explored the temporal dynamics and signal complexity of gamma band oscillations in first episode psychosis (FEP). To address this issue, gamma band analysis was performed in 15 FEP patients and 18 healthy controls who successfully performed an adapted 2-back working memory task...
May 2, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28464965/risk-of-transition-to-schizophrenia-following-first-admission-with-substance-induced-psychotic-disorder-a-population-based-longitudinal-cohort-study
#18
H L Alderson, D M Semple, C Blayney, F Queirazza, V Chekuri, S M Lawrie
BACKGROUND: The potential for drugs of abuse to induce acute psychotic symptoms is well recognised. However, the likelihood of transition from initial substance-induced psychotic disorder (SIPD) to chronic psychosis is much less well understood. This study investigated the rate of SIPD transition to schizophrenia (F20), the time to conversion and other possible related factors. METHODS: Using data from the Scottish Morbidity Record, we examined all patients (n = 3486) since their first admission to psychiatric hospital with a diagnosis of SIPD [International Classification of Diseases, Tenth Revision (ICD-10) codes F10-F19, with third digit five] from January 1997 to July 2012...
May 3, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28461116/anti-neuronal-anti-bodies-in-patients-with-early-psychosis
#19
O Mantere, M Saarela, T Kieseppä, T Raij, T Mäntylä, M Lindgren, E Rikandi, W Stoecker, B Teegen, J Suvisaari
It may be challenging to distinguish autoimmune encephalitis associated with anti-neuronal autoantibodies from primary psychiatric disorders. Here, serum was drawn from patients with a first-episode psychosis (n=70) or a clinical high-risk for psychosis (n=6) and controls (n=34). We investigated the serum prevalence of 24 anti-neuronal autoantibodies: IgG antibodies for anti-N-methyl-d-aspartate-type glutamate receptor (anti-NMDAR), glutamate and γ-aminobutyric acid alpha and beta receptors (GABA-a, GABA-b), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA), glycine receptor (GlyR), metabotropic glutamate receptor 1 and 5 (mGluR1, mGluR5), anti-Tr/Delta/notch-like epidermal growth factor-related receptor (DNER), contactin-associated protein-like 2 (CASPR2), myelin oligodendrocyte glycoprotein (MOG), glutamic acid decarboxylase-65 (GAD65), collapsin response mediator protein 5/crossveinless-2 (CV2), aquaporin-4 (AQP4), anti-dipeptidyl-peptidase-like protein-6 (DPPX), type 1 anti-neuronal nuclear antibody (ANNA-1, Hu), Ri, Yo, IgLON5, Ma2, zinc finger protein 4 (ZIC4), Rho GTPase-activating protein 26, amphiphysin, and recoverin, as well as IgA and IgM for dopamine-2-receptor (DRD2)...
April 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28460281/early-clinical-recovery-in-first-episode-psychosis-symptomatic-remission-and-its-correlates-at-1-year-follow-up
#20
Carmen Simonsen, Ann Faerden, Kristin Lie Romm, Akiah Ottesen Berg, Thomas Bjella, Kjetil Sundet, Torill Ueland, Ole Andreassen, Ingrid Melle
The aim was to gain more knowledge about early clinical recovery in first-episode psychosis (FEP). The interrelationship between symptomatic remission, poor global functioning and neurocognitive impairment was investigated. FEP participants (n =91) from the TOP study were investigated at baseline and 1-year follow-up. Symptomatic remission was defined by internationally standardized criteria. Poor global functioning was defined as GAF-F score ≤60. Neurocognitive impairment was defined as 1.5 standard deviation below healthy controls on a neuropsychological composite score...
April 24, 2017: Psychiatry Research
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