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https://www.readbyqxmd.com/read/29760976/glioblastoma-cells-labeled-by-robust-raman-tags-for-enhancing-imaging-contrast
#1
Li-Ching Huang, Yung-Ching Chang, Yi-Syuan Wu, Wei-Lun Sun, Chan-Chuan Liu, Chun-I Sze, Shiuan-Yeh Chen
Complete removal of a glioblastoma multiforme (GBM), a highly malignant brain tumor, is challenging due to its infiltrative characteristics. Therefore, utilizing imaging agents such as fluorophores to increase the contrast between GBM and normal cells can help neurosurgeons to locate residual cancer cells during image guided surgery. In this work, Raman tag based labeling and imaging for GBM cells in vitro is described and evaluated. The cell membrane of a GBM adsorbs a substantial amount of functionalized Raman tags through overexpression of the epidermal growth factor receptor (EGFR) and "broadcasts" stronger pre-defined Raman signals than normal cells...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29721096/first-in-human-study-of-pet-and-optical-dual-modality-image-guided-surgery-in-glioblastoma-using-68-ga-irdye800cw-bbn
#2
Deling Li, Jingjing Zhang, Chongwei Chi, Xiong Xiao, Junmei Wang, Lixin Lang, Iqbal Ali, Gang Niu, Liwei Zhang, Jie Tian, Nan Ji, Zhaohui Zhu, Xiaoyuan Chen
Purpose : Despite the use of fluorescence-guided surgery (FGS), maximum safe resection of glioblastoma multiforme (GBM) remains a major challenge. It has restricted surgeons between preoperative diagnosis and intraoperative treatment. Currently, an integrated approach combining preoperative assessment with intraoperative guidance would be a significant step in this direction. Experimental design : We developed a novel 68 Ga-IRDye800CW-BBN PET/near-infrared fluorescence (NIRF) dual-modality imaging probe targeting gastrin-releasing peptide receptor (GRPR) in GBM...
2018: Theranostics
https://www.readbyqxmd.com/read/29719137/real-time-imaging-of-brain-tumor-for-image-guided-surgery
#3
REVIEW
Shuang Hu, Homan Kang, Yoonji Baek, Georges El Fakhri, Anren Kuang, Hak Soo Choi
The completion of surgical resection is a key prognostic factor in brain tumor treatment. This requires surgeons to identify residual tumors in theater as well as to margin the proximity of the tumor to adjacent normal tissue. Subjective assessments, such as texture palpation or visual tissue differences, are commonly used by oncology surgeons during resection to differentiate cancer lesions from normal tissue, which can potentially result in either an incomplete tumor resection, or accidental removal of normal tissue...
May 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29682074/language-mapping-in-awake-surgery-report-of-two-cases-with-review-of-language-networks
#4
Liang Hooi Lim, Zamzuri Idris, Faruque Reza, Wan Mohd Nazaruddin Wan Hassan, Laila Abd Mukmin, Jafri Malin Abdullah
The role of language in communication plays a crucial role in human development and function. In patients who have a surgical lesion at the functional language areas, surgery should be intricately planned to avoid incurring further morbidity. This normally requires extensive functional and anatomical mappings of the brain to identify regions that are involved in language processing and production. In our case report, regions of the brain that are important for language functions were studied before surgery by employing (a) extraoperative methods such as functional magnetic resonance imaging, transmagnetic stimulation, and magnetoencephalography; (b) during the surgery by utilizing intraoperative awake surgical methods such as an intraoperative electrical stimulation; and (c) a two-stage surgery, in which electrical stimulation and first mapping are made thoroughly in the ward before second remapping during surgery...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682064/awake-craniotomy-with-noninvasive-brain-mapping-by-3-tesla-functional-magnetic-resonance-imaging-for-excision-of-low-grade-glioma-a-case-of-a-young-patient-from-pakistan
#5
Atta Ul Aleem Bhatti, Nasir Khan Jakhrani, Maria Adnan Parekh
The past few years have seen increasing support for gross total resection in the management of low-grade gliomas (LGGs), with a greater extent of resection correlated with better overall survival, progression-free survival, and time to malignant transformation. There is consistent evidence in literature supporting extent of safe resection as a good prognostic indicator as well as positively affecting seizure control, symptomatic relief in pressure symptoms, and longer progression-free and total survival. The operative goal in most LGG cases is to maximize the extent of resection for these benefits while avoiding postoperative neurologic deficits...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29624151/histopathological-features-predictive-of-local-control-of-atypical-meningioma-after-surgery-and-adjuvant-radiotherapy
#6
William C Chen, Stephen T Magill, Ashley Wu, Harish N Vasudevan, Olivier Morin, Manish K Aghi, Philip V Theodosopoulos, Arie Perry, Michael W McDermott, Penny K Sneed, Steve E Braunstein, David R Raleigh
OBJECTIVE The goal of this study was to investigate the impact of adjuvant radiotherapy (RT) on local recurrence and overall survival in patients undergoing primary resection of atypical meningioma, and to identify predictive factors to inform patient selection for adjuvant RT. METHODS One hundred eighty-two patients who underwent primary resection of atypical meningioma at a single institution between 1993 and 2014 were retrospectively identified. Patient, meningioma, and treatment data were extracted from the medical record and compared using the Kaplan-Meier method, log-rank tests, multivariate analysis (MVA) Cox proportional hazards models with relative risk (RR), and recursive partitioning analysis...
April 6, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29619931/approaches-to-radiotherapy-in-metastatic-spinal-cord-compression
#7
Morten Hiul Suppl
Metastatic spinal cord compression is caused by the progression of metastatic lesions within the vicinity of the spinal cord. The consequences are very severe with loss of neurological function and severe pain. The standard treatment is surgical intervention followed by radiotherapy or radiotherapy alone. However, the majority of patients are treated with radiotherapy only due to contraindications to surgery and technical inoperability. Stereotactic body radiotherapy is a technology to deliver higher radiation dose to the radiotherapy target with the use of spatial coordinates...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29602604/hair-sparing-does-not-compromise-real-time-magnetic-resonance-imaging-guided-stereotactic-laser-fiber-placement-for-temporal-lobe-epilepsy
#8
Shikha Singh, Kevin K Kumar, Matthew J Rabon, Dana Dolce, Casey H Halpern
Pre-operative scalp shaving is conventionally thought to simplify postoperative cranial wound care, lower the rate of wound infections, and ease optimal incision localization. Over the past few decades, some neurosurgeons have refrained from scalp shaving in order to improve patient satisfaction with brain surgery. However, this hair-sparing approach has not yet been explored in the growing field of magnetic resonance-guided laser interstitial thermal therapy (MRgLITT). This study investigated the initial impact of a no-shave technique on post-operative wound infection rate as well as on entry and target accuracy in MRgLITT for mesial temporal epilepsy...
March 27, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29588245/predicting-dural-tear-in-compound-depressed-skull-fractures-a-prospective-multi-center-correlational-study
#9
Shemsedin Musefa Salia, Hagos Biluts Mersha, Abenezer Tirsit Aklilu, Abate Sahlu Baleh, Morten Lund-Johansen
BACKGROUND: Compound depressed skull fractures (DSF) are neurosurgical emergencies. Pre-operative knowledge of dural status is indispensable for treatment decision. This study aims to determine predictors of dural tear from clinical and imaging characteristics in patients with compound DSF. PATIENTS AND METHODS: The authors conducted a prospective, multi-center correlational study in neurosurgical hospitals in Addis Ababa, Ethiopia. Patients (n=128) operated from January 1 to October 31, 2016 were included...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29559187/fluorescein-guided-resection-of-brain-arteriovenous-malformations-a-short-series
#10
Maxime Bretonnier, Pierre-Louis Henaux, Xavier Morandi, Pierre-Jean Le Reste
Brain arteriovenous malformations (AVM) are complex and highly challenging lesions, for which intra-operative indocyanin green fluorescence video angiography is widely used. Fluorescein video angiography (FVA) recently appeared as an alternative technique but the feasibility and usefulness of this technique is yet uncertain. This short series reports our preliminary experience of FVA in intracranial AVM surgery. We retrospectively studied the cases of seven patients who had FVA for an AVM surgery. The primary objective of this study was to assess the utility of FVA as judged by the surgeon...
March 17, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29554343/stereoelectroencephalography-guided-laser-ablations-in-patients-with-neocortical-pharmacoresistant-focal-epilepsy-concept-and-operative-technique
#11
Louis Ross, Ahsan M Naduvil, Juan C Bulacio, Imad M Najm, Jorge A Gonzalez-Martinez
BACKGROUND: Laser ablation surgery has had encouraging results in the treatment of multiple intracranial diseases including primary and metastatic brain tumors, radiation necrosis, and epilepsy. The use of the stereoelectroencephalography (SEEG) method in combination with laser thermocoagulation therapy with the goal of modulating epileptic networks in patients with neocortical nonlesional phamacoresistant epilepsy has not been previously described. OBJECTIVE: To describe the novel methodological and conceptual aspects related to SEEG-guided laser ablations in patients with magnetic resonance imaging (MRI)-negative pharmacoresistant neocortical focal epilepsy...
March 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29521555/improving-surgical-outcome-for-gliomas-with-intraoperative-mapping
#12
François-Xavier Ferracci, Hugues Duffau
Radical glioma resection improves overall survival, both in low-grade and high-grade glial tumors. However, preservation of the quality of life is also crucial. Areas covered: Due to the diffuse feature of gliomas, which invade the central nervous system, and due to considerable variations of brain organization among patients, an individual cerebral mapping is mandatory to solve the classical dilemma between the oncological and functional issues. Because functional neuroimaging is not reliable enough, intraoperative electrical stimulation, especially in awake patients benefiting from a real-time cognitive monitoring, is the best way to increase the extent of resection while sparing eloquent neural networks...
April 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29510282/multimodal-approach-for-radical-excision-of-focal-cortical-dysplasia-by-combining-advanced-magnetic-resonance-imaging-data-to-intraoperative-ultrasound-electrocorticography-and-cortical-stimulation-a-preliminary-experience
#13
Giovanni Tringali, Beatrice Bono, Ivano Dones, Roberto Cordella, Giuseppe Didato, Flavio Villani, Francesco Prada
BACKGROUND AND OBJECTIVE: Type II focal cortical dysplasia is the most common malformation of cortical development associated with drug resistant epilepsy and susceptible to surgical resection. Although, at present, advanced imaging modalities are capable of detecting most cortical disorders, it is still a challenge for the surgeon to visualize them intraoperatively. The lack of direct identification between normal brain and subtle dysplastic tissue may explain the poor results in terms of being seizure-free versus other forms of epilepsy...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29477100/diversity-of-brain-metastases-screening-and-management-in-non-small-cell-lung-cancer-in-europe-results-of-the-european-organisation-for-research-and-treatment-of-cancer-lung-cancer-group-survey
#14
Antonin Levy, Corinne Faivre-Finn, Baktiar Hasan, Eleonora De Maio, Anna S Berghoff, Nicolas Girard, Laurent Greillier, Sylvie Lantuéjoul, Mary O'Brien, Martin Reck, Anne-Marie C Dingemans, Silvia Novello, Thierry Berghmans, Benjamin Besse, Lizza Hendriks
BACKGROUND: Brain metastases (BM) are frequent in non-small cell lung cancer (NSCLC) patients, but there is a lack of evidence-based management of this patient group. We aimed to capture a snapshot of routine BM management in Europe to identify relevant research questions for future clinical trials. METHODS: An EORTC Lung Cancer Group (LCG) online survey containing questions on NSCLC BM screening and treatment was distributed between 16/02/17 and 15/06/17 to worldwide EORTC LCG members, and through several European scientific societies in the thoracic oncology field...
April 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29454130/abscess-within-a-glioblastoma-mimicking-a-matryoshka-doll
#15
Kislay Kishore, Manish Beniwal, Shilpa Rao, K V L Narasinga Rao, Vikas Vazhayil, Dwarakanath Srinivas, Sampath Somanna
BACKGROUND: Abscess coexisting within a brain tumor is rare. Case reports in the literature primarily consist of sellar pathology and parenchymal lesions, including meningioma, glioma, and metastases. We report a case of glioblastoma with an intratumoral abscess in a middle-aged patient with no prior invasive procedure or systemic focus of infection. CASE DESCRIPTION: A 45-year-old woman presented with new-onset generalized seizures and rapidly progressive left hemiparesis...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29425986/is-edema-a-matter-of-concern-after-laser-ablation-of-epileptogenic-focus
#16
Vivek Tandon, Michael Lang, Poodipedi Sarat Chandra, Ashwini Sharan, Ajay Garg, Manjari Tripathi
BACKGROUND: A stereotactically placed laser fiber can deliver thermal energy to an epileptogenic focus in the brain. This procedure is done under intraoperative (thermography) magnetic resonance imaging (MRI) guidance. Thermoablation can lead to edema in the surrounding area and can cause a secondary insult. In this report of 3 cases, we have quantified the edema produced after laser ablation by sequential MRI in the immediate postoperative period. CASE DESCRIPTIONS: Three patients with intractable epilepsy underwent a detailed neurologic and neuroradiologic workup to localize the site of epileptogenic foci...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29412496/characterization-of-active-and-infiltrative-tumorous-subregions-from-normal-tissue-in-brain-gliomas-using-multiparametric-mri
#17
Anahita Fathi Kazerooni, Mahnaz Nabil, Mehdi Zeinali Zadeh, Kavous Firouznia, Farid Azmoudeh-Ardalan, Alejandro F Frangi, Christos Davatzikos, Hamidreza Saligheh Rad
BACKGROUND: Targeted localized biopsies and treatments for diffuse gliomas rely on accurate identification of tissue subregions, for which current MRI techniques lack specificity. PURPOSE: To explore the complementary and competitive roles of a variety of conventional and quantitative MRI methods for distinguishing subregions of brain gliomas. STUDY TYPE: Prospective. POPULATION: Fifty-one tissue specimens were collected using image-guided localized biopsy surgery from 10 patients with newly diagnosed gliomas...
February 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29408716/scanning-fiber-endoscope-improves-detection-of-5-aminolevulinic-acid-induced-protoporphyrin-ix-fluorescence-at-the-boundary-of-infiltrative-glioma
#18
Evgenii Belykh, Eric J Miller, Danying Hu, Nikolay L Martirosyan, Eric C Woolf, Adrienne C Scheck, Vadim A Byvaltsev, Peter Nakaji, Leonard Y Nelson, Eric J Seibel, Mark C Preul
OBJECTIVE: Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas. Current wide-field imaging technologies do not have sufficient sensitivity to detect low PpIX concentrations. We evaluated a scanning fiber endoscope (SFE) for detection of PpIX fluorescence in gliomas and compared it to an operating microscope (OPMI) equipped with a fluorescence module and to a benchtop confocal laser scanning microscope (CLSM)...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29387530/connectivity-derived-thalamic-segmentation-in-deep-brain-stimulation-for-tremor
#19
Harith Akram, Viswas Dayal, Philipp Mahlknecht, Dejan Georgiev, Jonathan Hyam, Thomas Foltynie, Patricia Limousin, Enrico De Vita, Marjan Jahanshahi, John Ashburner, Tim Behrens, Marwan Hariz, Ludvic Zrinzo
The ventral intermediate nucleus (VIM) of the thalamus is an established surgical target for stereotactic ablation and deep brain stimulation (DBS) in the treatment of tremor in Parkinson's disease (PD) and essential tremor (ET). It is centrally placed on a cerebello-thalamo-cortical network connecting the primary motor cortex, to the dentate nucleus of the contralateral cerebellum through the dentato-rubro-thalamic tract (DRT). The VIM is not readily visible on conventional MR imaging, so identifying the surgical target traditionally involved indirect targeting that relies on atlas-defined coordinates...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29356927/image-guided-resection-of-glioblastoma-in-eloquent-brain-areas-facilitated-by-laser-surface-thermal-therapy-clinical-outcomes-and-long-term-results
#20
Artem Rozumenko, Valentyn Kliuchka, Volodymir Rozumenko, Vera Semenova, Sergii Kolesnyk, Zoja Fedorenko
The increased interest in the application of lasers in neuro-oncology prompted us to present our experience of using the laser technologies in the treatment of cerebral gliomas. The aim of the study was to evaluate the clinical efficacy of image-guided laser surface thermal therapy (LSTT) and its influence on survival of patients with glioblastoma (GBM).Data of 91 patients (49 males, 42 females, mean age 51.4 years, range 23-70 years) with supratentorial GBMs located in close vicinity to or within the eloquent brain areas were retrospectively analyzed...
January 22, 2018: Neurosurgical Review
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