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https://www.readbyqxmd.com/read/28199993/intraoperative-thresholds-for-capsular-stimulation-are-reliable-for-chronic-pallidal-deep-brain-stimulation-in-dystonia
#1
René Reese, Martin M Reich, Daniela Falk, Günther Deuschl, H Maximilian Mehdorn, Jens Volkmann
BACKGROUND: The threshold current for inducing muscle contractions by stimulation of pyramidal tract fibres adjacent to the globus pallidus internus (GPi) is, besides microelectrode recordings for the determination of nuclear boundaries, currently the only neurophysiological marker for intraoperative refinement of the anatomically planned target point for pallidal deep brain stimulation (GPi-DBS) in dystonia. OBJECTIVES: To determine the relationship between intraoperative thresholds for muscle contractions under general anaesthesia and postoperative thresholds in GPi-DBS...
February 16, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28169225/intensity-based-2d-3d-registration-for-lead-localization-in-robot-guided-deep-brain-stimulation
#2
Stefan Hunsche, Dieter Sauner, Faycal El Majdoub, Clemens Neudorfer, Joerg Poggenborg, Axel Gossmann, Mohammad Maarouf
Intraoperative assessment of lead localization has become a standard procedure during deep brain stimulation (DBS) surgery in many centers, allowing immediate verification of targeting accuracy and, if necessary, adjustment of the trajectory. The most suitable imaging modality to determine lead positioning, however, remains controversially discussed. Current approaches entail the implementation of computed tomography and magnetic resonance imaging. In the present study, we adopted the technique of intensity-based 2D 3D registration that is commonly employed in stereotactic radiotherapy and spinal surgery...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28165374/evaluation-of-epha2-and-ephb4-as-targets-for-image-guided-colorectal-cancer-surgery
#3
Marieke A Stammes, Hendrica A J M Prevoo, Meyke C Ter Horst, Stéphanie A Groot, Cornelis J H Van de Velde, Alan B Chan, Lioe-Fee de Geus-Oei, Peter J K Kuppen, Alexander L Vahrmeijer, Elena B Pasquale, Cornelis F M Sier
Targeted image-guided oncologic surgery (IGOS) relies on the recognition of cell surface-associated proteins, which should be abundantly present on tumor cells but preferably absent on cells in surrounding healthy tissue. The transmembrane receptor tyrosine kinase EphA2, a member of the A class of the Eph receptor family, has been reported to be highly overexpressed in several tumor types including breast, lung, brain, prostate, and colon cancer and is considered amongst the most promising cell membrane-associated tumor antigens by the NIH...
February 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28121927/primary-cerebral-malignant-melanoma-a-case-report-with-literature-review
#4
Kai Tang, Xiangyi Kong, Gengsheng Mao, Ming Qiu, Haibo Zhu, Lei Zhou, Qingbin Nie, Yi Xu, Shiwei Du
Primary intracranial melanomas are uncommon and constitute approximately 1% of all melanoma cases and 0.07% of all brain tumors. In nature, these primary melanomas are very aggressive and can spread to other organs.We report an uncommon case of primary cerebral malignant melanoma-a challenging diagnosis guided by clinical presentations, radiological features, and surgical biopsy results, aiming to emphasize the importance of considering primary melanoma when making differential diagnoses of intracranial lesions...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28114956/near-infrared-fluorescent-imaging-of-brain-tumor-with-ir780-dye-incorporated-phospholipid-nanoparticles
#5
Shihong Li, Jennifer Johnson, Anderson Peck, Qian Xie
BACKGROUND: Near-IR fluorescence (NIRF) imaging is becoming a promising approach in preclinical tumor detection and clinical image-guided oncological surgery. While heptamethine cyanine dye IR780 has excellent tumor targeting and imaging potential, its hydrophobic property limits its clinical use. In this study, we developed nanoparticle formulations to facilitate the use of IR780 for fluorescent imaging of malignant brain tumor. METHODS: Self-assembled IR780-liposomes and IR780-phospholipid micelles were prepared and their NIRF properties were characterized...
January 23, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28097209/fluorescence-guided-resection-of-brain-tumor-review-of-the-significance-of-intraoperative-quantification-of-protoporphyrin-ix-fluorescence
#6
REVIEW
Zheng Huang, Songsheng Shi, Haixia Qiu, Desheng Li, Jian Zou, Shaoshan Hu
Surgical removal of tumor mass is a common approach in the management of brain tumors. However, the precise delineation of normal tissue from tumor tissue for a complete resection of tumor mass in brain tumor surgery remains a difficult task for neurosurgeons. Aminolevulinic acid (ALA)-mediated exgogenous fluorescence of protoporphyrin IX (PpIX) is a sensitive approach for tumor imaging. Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion...
January 2017: Neurophotonics
https://www.readbyqxmd.com/read/28047692/we-h-209-01-advances-in-ultrasound-therapy
#7
K Hynynen
: Focused ultrasound has been shown to be the only method that allows noninvasive thermal coagulation of tissues and recently this potential has been explored for image-guided drug delivery. In this presentation, the advances in ultrasound phased array technology for energy delivery, exposure monitoring and control will be discussed. Experimental results from novel multi-frequency transmit/receive arrays will be presented. In addition, the feasibility of fully electronically focused and steered high power arrays with many thousands of transducer elements will be discussed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046536/we-h-209-00-carson-zagzebski-distinguished-lectureship-image-guided-ultrasound-therapy
#8
Thaddeus Wilson
: Focused ultrasound has been shown to be the only method that allows noninvasive thermal coagulation of tissues and recently this potential has been explored for image-guided drug delivery. In this presentation, the advances in ultrasound phased array technology for energy delivery, exposure monitoring and control will be discussed. Experimental results from novel multi-frequency transmit/receive arrays will be presented. In addition, the feasibility of fully electronically focused and steered high power arrays with many thousands of transducer elements will be discussed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28018730/raman-spectroscopy-detects-distant-invasive-brain-cancer-cells-centimeters-beyond-mri-capability-in-humans
#9
Michael Jermyn, Joannie Desroches, Jeanne Mercier, Karl St-Arnaud, Marie-Christine Guiot, Frederic Leblond, Kevin Petrecca
Surgical treatment of brain cancer is limited by the inability of current imaging capabilities such as magnetic resonance imaging (MRI) to detect the entirety of this locally invasive cancer. This results in residual cancer cells remaining following surgery, leading to recurrence and death. We demonstrate that intraoperative Raman spectroscopy can detect invasive cancer cells centimeters beyond pathological T1-contrast-enhanced and T2-weighted MRI signals. This intraoperative optical guide can be used to detect invasive cancer cells and minimize post-surgical cancer burden...
December 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27959970/magnetic-resonance-thermometry-guided-stereotactic-laser-ablation-of-cavernous-malformations-in-drug-resistant-epilepsy-imaging-and-clinical-results
#10
D Jay McCracken, Jon T Willie, Brad Fernald, Amit M Saindane, Daniel L Drane, Daniel L Barrow, Robert E Gross
BACKGROUND: Surgery is indicated for cerebral cavernous malformations (CCM) that cause medically refractory epilepsy. Real-time magnetic resonance thermography (MRT)-guided stereotactic laser ablation (SLA) is a minimally invasive approach to treating focal brain lesions. SLA of CCM has not previously been described. OBJECTIVE: To describe MRT-guided SLA, a novel approach to treating CCM-related epilepsy, with respect to feasibility, safety, imaging, and seizure control in 5 consecutive patients...
March 2016: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/27924360/perfusion-imaging-of-brain-gliomas-using-arterial-spin-labeling-correlation-with-histopathological-vascular-density-in-mri-guided-biopsies
#11
Di Ningning, Pang Haopeng, Dang Xuefei, Cheng Wenna, Ren Yan, Wu Jingsong, Yao Chengjun, Yao Zhenwei, Feng Xiaoyuan
INTRODUCTION: This study was designed to determine if cerebral blood flow (CBF) derived from arterial spin labeling (ASL) perfusion imaging could be used to quantitatively evaluate the microvascular density (MVD) of brain gliomas on a "point-to-point" basis by matching CBF areas and surgical biopsy sites as accurate as possible. METHODS: The study enrolled 47 patients with treatment-naive brain gliomas who underwent preoperative ASL, 3D T1-weighted imaging with gadolinium contrast enhancement (3D T1C+), and T2 fluid acquisition of inversion recovery (T2FLAIR) sequences before stereotactic surgery...
January 2017: Neuroradiology
https://www.readbyqxmd.com/read/27856790/virtual-wall-based-haptic-guided-teleoperated-surgical-robotic-system-for-single-port-brain-tumor-removal-surgery
#12
Sungmin Seung, Hongseok Choi, Jongseong Jang, Young Soo Kim, Jong-Oh Park, Sukho Park, Seong Young Ko
This article presents a haptic-guided teleoperation for a tumor removal surgical robotic system, so-called a SIROMAN system. The system was developed in our previous work to make it possible to access tumor tissue, even those that seat deeply inside the brain, and to remove the tissue with full maneuverability. For a safe and accurate operation to remove only tumor tissue completely while minimizing damage to the normal tissue, a virtual wall-based haptic guidance together with a medical image-guided control is proposed and developed...
January 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/27813457/ventricular-catheter-entry-site-and-not-catheter-tip-location-predicts-shunt-survival-a-secondary-analysis-of-3-large-pediatric-hydrocephalus-studies
#13
MULTICENTER STUDY
William E Whitehead, Jay Riva-Cambrin, Abhaya V Kulkarni, John C Wellons, Curtis J Rozzelle, Mandeep S Tamber, David D Limbrick, Samuel R Browd, Robert P Naftel, Chevis N Shannon, Tamara D Simon, Richard Holubkov, Anna Illner, D Douglas Cochrane, James M Drake, Thomas G Luerssen, W Jerry Oakes, John R W Kestle
OBJECTIVE Accurate placement of ventricular catheters may result in prolonged shunt survival, but the best target for the hole-bearing segment of the catheter has not been rigorously defined. The goal of the study was to define a target within the ventricle with the lowest risk of shunt failure. METHODS Five catheter placement variables (ventricular catheter tip location, ventricular catheter tip environment, relationship to choroid plexus, catheter tip holes within ventricle, and crosses midline) were defined, assessed for interobserver agreement, and evaluated for their effect on shunt survival in univariate and multivariate analyses...
February 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27800481/intraoperative-fluorescence-imaging-for-personalized-brain-tumor-resection-current-state-and-future-directions
#14
REVIEW
Evgenii Belykh, Nikolay L Martirosyan, Kaan Yagmurlu, Eric J Miller, Jennifer M Eschbacher, Mohammadhassan Izadyyazdanabadi, Liudmila A Bardonova, Vadim A Byvaltsev, Peter Nakaji, Mark C Preul
INTRODUCTION: Fluorescence-guided surgery is one of the rapidly emerging methods of surgical "theranostics." In this review, we summarize current fluorescence techniques used in neurosurgical practice for brain tumor patients as well as future applications of recent laboratory and translational studies. METHODS: Review of the literature. RESULTS: A wide spectrum of fluorophores that have been tested for brain surgery is reviewed. Beginning with a fluorescein sodium application in 1948 by Moore, fluorescence-guided brain tumor surgery is either routinely applied in some centers or is under active study in clinical trials...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27758940/ices-intraoperative-stereotactic-computed-tomography-guided-endoscopic-surgery-for-brain-hemorrhage-a-multicenter-randomized-controlled-trial
#15
Paul Vespa, Daniel Hanley, Joshua Betz, Alan Hoffer, Johnathan Engh, Robert Carter, Peter Nakaji, Chris Ogilvy, Jack Jallo, Warren Selman, Amanda Bistran-Hall, Karen Lane, Nichol McBee, Jeffery Saver, Richard E Thompson, Neil Martin
BACKGROUND AND PURPOSE: Intracerebral hemorrhage (ICH) is a devastating disease without a proven therapy to improve long-term outcome. Considerable controversy about the role of surgery remains. Minimally invasive endoscopic surgery for ICH offers the potential of improved neurological outcome. METHODS: We tested the hypothesis that intraoperative computerized tomographic image-guided endoscopic surgery is safe and effectively removes the majority of the hematoma rapidly...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27751554/safety-and-efficacy-of-minimally-invasive-surgery-plus-alteplase-in-intracerebral-haemorrhage-evacuation-mistie-a-randomised-controlled-open-label-phase-2-trial
#16
Daniel F Hanley, Richard E Thompson, John Muschelli, Michael Rosenblum, Nichol McBee, Karen Lane, Amanda J Bistran-Hall, Steven W Mayo, Penelope Keyl, Dheeraj Gandhi, Tim C Morgan, Natalie Ullman, W Andrew Mould, J Ricardo Carhuapoma, Carlos Kase, Wendy Ziai, Carol B Thompson, Gayane Yenokyan, Emily Huang, William C Broaddus, R Scott Graham, E Francois Aldrich, Robert Dodd, Cristanne Wijman, Jean-Louis Caron, Judy Huang, Paul Camarata, A David Mendelow, Barbara Gregson, Scott Janis, Paul Vespa, Neil Martin, Issam Awad, Mario Zuccarello
BACKGROUND: Craniotomy, according to the results from trials, does not improve functional outcome after intracerebral haemorrhage. Whether minimally invasive catheter evacuation followed by thrombolysis for clot removal is safe and can achieve a good functional outcome is not known. We investigated the safety and efficacy of alteplase, a recombinant tissue plasminogen activator, in combination with minimally invasive surgery (MIS) in patients with intracerebral haemorrhage. METHODS: MISTIE was an open-label, phase 2 trial that was done in 26 hospitals in the USA, Canada, the UK, and Germany...
November 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27713067/clinical-experience-with-intraoperative-ultrasonographic-image-in-microsurgical-resection-of-cerebral-arteriovenous-malformations
#17
Hongzhi Xu, Zhiyong Qin, Ming Xu, Chunjui Chen, Junjie Zhang, Xiancheng Chen
BACKGROUND: Intraoperative ultrasonography is widely used in neurosurgery for the management of intracerebral hematoma and brain tumor. However, the clinical value of this method in the surgery of cerebral arteriovenous malformations (AVMs) has not been reported. In this study, the application of intraoperative ultrasonography for AVM surgery was evaluated prospectively. METHODS: This prospective clinical study comprised 41 patients who underwent microsurgical resection of cerebral AVMs at our institute...
January 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27685657/use-of-intraoperative-ct-to-predict-the-accuracy-of-microelectrode-recording-during-deep-brain-stimulation-surgery-a-proof-of-concept-study
#18
Ryan B Kochanski, Mena G Kerolus, Gian Pal, Leo Verhagen Metman, Sepehr Sani
OBJECTIVES: Intraoperative computed tomography (iCT) is currently used to confirm the target location of the microelectrode (ME) during microelectrode recording (MER) and ultimate location of deep brain stimulation (DBS) leads at our institution. We evaluated whether iCT can be used to predict the trajectory and accuracy of the ME track. PATIENTS AND METHODS: Intraoperative imaging profiles of ten consecutive patients who had undergone DBS surgery were retrospectively reviewed...
November 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27659837/mri-guided-laser-interstitial-thermal-therapy-for-the-treatment-of-low-grade-gliomas-in-children-a-case-series-review-description-of-the-current-technologies-and-perspectives
#19
Zulma Tovar-Spinoza, Hoon Choi
BACKGROUND: Pediatric low-grade gliomas (LGGs) account for approximately half of all pediatric central nervous system tumors. The low-grade gliomas' first line of treatment is gross total resection. However, when gross total resection is not possible, options for adjuvant therapy are limited. MRI-guided laser ablation (magnetic resonance-guided laser interstitial thermal therapy (MRgLITT)) offers a new option for treatment in selected cases. We present a description of the current MRgLITT technology and an exemplary case-series review of our experience in its use in LGGs...
October 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27621252/pituitary-incidentalomas-a-guide-to-assessment-treatment-and-follow-up
#20
REVIEW
Stavroula Α Paschou, Andromachi Vryonidou, Dimitrios G Goulis
Pituitary incidentalomas are lesions which are detected incidentally in the pituitary gland during imaging procedures for unrelated causes, such as headache, trauma or symptoms involving the neck or central nervous system. The wide application of sensitive brain imaging techniques (CT, MRI) has led to an increasing recognition of such lesions. Although the etiology of pituitary incidentalomas covers a wide range of pathologies, most of them (∼90%) are benign adenomas; nonetheless, they may result in visual and/or neurologic abnormalities...
October 2016: Maturitas
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