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https://www.readbyqxmd.com/read/29786471/the-effects-of-polyphenol-supplementation-on-adipose-tissue-morphology-and-gene-expression-in-overweight-and-obese-humans
#1
Jasper Most, Ines Warnke, Mark V Boekschoten, Johan W E Jocken, Philip de Groot, Angelika Friedel, Igor Bendik, Gijs H Goossens, Ellen E Blaak
Dietary polyphenols have beneficial effects on adipose tissue mass and function in rodents, but human studies are scarce. In a randomized, placebo-controlled study, 25 (10 women) overweight and obese humans received a combination of the polyphenols epigallocatechin-gallate and resveratrol (282 mg/d, 80 mg/d, respectively, EGCG+RES, n = 11) or placebo (PLA, n = 14) supplementation for 12 weeks. Abdominal subcutaneous adipose tissue (SAT) biopsies were collected for assessment of adipocyte morphology and micro-array analysis...
May 1, 2018: Adipocyte
https://www.readbyqxmd.com/read/29786102/the-ucp2-866g-a-ala55val-and-ucp3-55c-t-polymorphisms-are-associated-with-premature-coronary-artery-disease-and-cardiovascular-risk-factors-in-mexican-population
#2
Ricardo Gamboa, Claudia Huesca-Gómez, Vanessa López-Pérez, Rosalinda Posadas-Sánchez, Guillermo Cardoso-Saldaña, Aida Medina-Urrutia, Juan Gabriel Juárez-Rojas, María Elena Soto, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1...
May 21, 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29785070/analysis-of-antibiotics-resistant-genes-in-different-strains-of-staphylococcus-aureus
#3
Benson Otarigho, Mofolusho O Falade
The control of Staphylococcus aureus infection is being hampered by methicillin and other resistant strains. The identification of the unique antibiotic resistant genes from the genomes of various strains of S. aureus is of interest. We analyzed 11 S. aureus genomes sequences for Antibiotics Resistance Genes (ARGs) using CARD 2017 platform. We identified 32 ARGs across 11 S. aureus strains. Tet(38), norB, lmrB, mepA and mepR were present across genomes except for S. aureus strain UTSW MRSA 55. The mepA and mepR were found across 11 different genomes...
2018: Bioinformation
https://www.readbyqxmd.com/read/29783856/increased-aqp7-abundance-in-skeletal-muscle-from-obese-men-with-type-2-diabetes
#4
Janne Lebeck, Esben Søndergaard, Søren Nielsen
AQP7 facilitates the transport of glycerol across cell membranes. In mice, fasting and refeeding regulate adipose tissue AQP7 abundance and a role in controlling triglyceride accumulation in adipose tissue has been proposed. AQP7 is also expressed in skeletal muscle, where its function remains to be determined. Here, the abundance of AQP7 in abdominal subcutaneous adipose tissue (SAT) and skeletal muscle was evaluated in the overnight fasted and postprandial state in eight lean and eight obese men with type 2 diabetes (T2D)...
May 21, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29777233/visceral-adiposity-and-high-adiponectin-levels-are-associated-with-the-prevalence-of-pancreatic-cystic-lesions
#5
Suguru Mizuno, Yousuke Nakai, Hiroyuki Isayama, Takeharu Yoshikawa, Kei Saito, Naminatsu Takahara, Hirofumi Kogure, Minoru Tada, Naoto Hayashi, Kazuhiko Koike
OBJECTIVES: Obesity is increasing in developed countries and is a risk factor for pancreatic cancer (PaC). We previously reported that obesity was associated with pancreatic cystic lesions (PCLs), which are both precursors of, and risk factors for, PaC. In the present study, we further investigated the relationship between visceral adiposity and adiponectin levels and the extent of PCLs. METHODS: Individuals who underwent comprehensive health screening at our institution between January 2008 and March 2013 were analyzed...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29769301/incubation-behaviours-of-oviraptorosaur-dinosaurs-in-relation-to-body-size
#6
Kohei Tanaka, Darla K Zelenitsky, Junchang Lü, Christopher L DeBuhr, Laiping Yi, Songhai Jia, Fang Ding, Mengli Xia, Di Liu, Caizhi Shen, Rongjun Chen
Most birds sit on their eggs during incubation, a behaviour that likely evolved among non-avian dinosaurs. Several 'brooding' specimens of smaller species of oviraptorosaurs and troodontids reveal these non-avian theropods sat on their eggs, although little is known of incubation behaviour in larger theropod species. Here we examine egg clutches over a large body size range of oviraptorosaurs in order to understand the potential effect of body size on incubation behaviour. Eggshell porosity indicates that the eggs of all oviraptorosaurs were exposed in the nest, similar to brooding birds...
May 2018: Biology Letters
https://www.readbyqxmd.com/read/29769150/adipose-tissue-uncoupling-protein-1-levels-and-function-are-increased-in-a-mouse-model-of-developmental-obesity-induced-by-maternal-exposure-to-high-fat-diet
#7
E Bytautiene Prewit, C Porter, M La Rosa, N Bhattarai, H Yin, P Gamble, T Kechichian, L S Sidossis
With brown adipose tissue (BAT) becoming a possible therapeutic target to counteract obesity, the prenatal environment could represent a critical window to modify BAT function and browning of white AT. We investigated if levels of uncoupling protein 1 (UCP1) and UCP1-mediated thermogenesis are altered in offspring exposed to prenatal obesity. Female CD-1 mice were fed a high-fat (HF) or standard-fat (SF) diet for 3 months before breeding. After weaning, all pups were placed on SF. UCP1 mRNA and protein levels were quantified using quantitative real-time PCR and Western blot analysis, respectively, in brown (BAT), subcutaneous (SAT) and visceral (VAT) adipose tissues at 6 months of age...
May 17, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29768501/secretion-of-autoimmune-antibodies-in-the-human-subcutaneous-adipose-tissue
#8
Daniela Frasca, Alain Diaz, Maria Romero, Seth Thaller, Bonnie B Blomberg
The adipose tissue (AT) contributes to systemic and B cell intrinsic inflammation, reduced B cell responses and secretion of autoimmune antibodies. In this study we show that adipocytes in the human obese subcutaneous AT (SAT) secrete several pro-inflammatory cytokines and chemokines, which contribute to the establishment and maintenance of local and systemic inflammation, and consequent suboptimal immune responses in obese individuals, as we have previously shown. We also show that pro-inflammatory chemokines recruit immune cells expressing the corresponding receptors to the SAT, where they also contribute to local and systemic inflammation, secreting additional pro-inflammatory mediators...
2018: PloS One
https://www.readbyqxmd.com/read/29767842/more-than-just-co-2-recycling-corticular-photosynthesis-as-a-mechanism-to-reduce-the-risk-of-an-energy-crisis-induced-by-low-oxygen
#9
Christiane Wittmann, Hardy Pfanz
Reassimilation of internal CO2 via corticular photosynthesis (PScort ) has an important effect on the carbon economy of trees. However, little is known about its role as a source of O2 supply to the stem parenchyma and its implications in consumption and movement of O2 within trees. PScort of young Populus nigra (black poplar) trees was investigated by combining optical micro-optode measurements with monitoring of stem chlorophyll fluorescence. During times of zero sap flow in spring, stem oxygen concentrations (cO2 ) exhibited large temporal changes...
May 16, 2018: New Phytologist
https://www.readbyqxmd.com/read/29765096/temporal-changes-in-immune-cell-composition-and-cytokines-in-response-to-chemoradiation-in-rectal-cancer
#10
Yong Joon Lee, Sat Byol Lee, Suk Kyung Beak, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Kang Young Lee, Nam Kyu Kim, Byung Soh Min
We measured systemic changes in the immune response in 92 patients receiving preoperative chemoradiation therapy (CRT) and subsequent surgery for rectal cancer. The peripheral blood was sampled five times from the onset of CRT until surgery. Lymphocytes decreased continuously during CRT but increased after CRT. The increased lymphocyte population was predominantly CD8+ T lymphocytes, which accounted for a significantly larger proportion in patients without residual lymph node metastasis than in those with residual lymph node metastasis...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764718/metabolic-syndrome-associates-with-left-atrial-dysfunction
#11
K Nyman, M Granér, M O Pentikäinen, J Lundbom, A Hakkarainen, R Sirén, M S Nieminen, M-R Taskinen, N Lundbom, K Lauerma
BACKGROUND AND AIMS: Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. METHODS AND RESULTS: Myocardial and hepatic triglyceride contents were measured with 1.5T 1 H-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS...
February 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29761755/a-deadly-wait-for-u-s-health-insurance-coverage-sitting-on-the-couch-with-malaria
#12
Jonathan S Schultz, Adam J Atherly, Andrés F Henao-Martínez
Uninsured and unprepared travelers to countries with endemic tropical diseases pose great health-care burdens and financial risks on returning to the United States. We discuss the delayed presentation of an uninsured U.S. traveler returning from West Africa with severe malaria who required intensive care measures to save his life. Despite being critically ill on his return, he sat rigoring on his couch taking antipyretics for 3 days, while he applied for insurance on the Affordable Care Act website and waited for approval because he was fearful of the costs of seeking care...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29760731/recovery-of-donor-hematopoiesis-after-graft-failure-and-second-hematopoietic-stem-cell-transplantation-with-intraosseous-administration-of-mesenchymal-stromal-cells
#13
Nataliya Petinati, Nina Drize, Natalia Sats, Natalya Risinskaya, Andrey Sudarikov, Michail Drokov, Daria Dubniak, Alina Kraizman, Maria Nareyko, Natalia Popova, Maya Firsova, Larisa Kuzmina, Elena Parovichnikova, Valeriy Savchenko
Multipotent mesenchymal stromal cells (MSCs) participate in the formation of bone marrow niches for hematopoietic stem cells. Donor MSCs can serve as a source of recovery for niches in patients with graft failure (GF) after allogeneic bone marrow (BM) transplantation. Since only few MSCs reach the BM after intravenous injection, MSCs were implanted into the iliac spine. For 8 patients with GF after allo-BMT, another hematopoietic stem cell transplantation with simultaneous implantation of MSCs from their respective donors into cancellous bone was performed...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29753196/impact-of-an-auditory-stimulus-on-baseline-cortisol-concentrations-in-clinically-normal-dogs
#14
T E Gin, M L Puchot, A K Cook
Baseline cortisol concentrations are routinely used to screen dogs for hypoadrenocorticism (HOC); this diagnosis must then be confirmed with an ACTH stimulation test. A baseline cortisol concentration less than 55 nmol/L (2 μg/dL) is highly sensitive for HOC but lacks specificity, with a false positive rate >20%. Many dogs with nonadrenal disease are therefore subjected to unnecessary additional testing. It was hypothesized that exposure to an unpleasant auditory stimulus before sample collection would improve the specificity of baseline cortisol measurements in dogs with nonadrenal disease by triggering cortisol production...
March 19, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29751203/effect-of-adipose-tissue-volume-on-prognosis-in-patients-with-non-small-cell-lung-cancer
#15
Jeong Won Lee, Ho Sung Lee, Ju Ock Na, Sang Mi Lee
OBJECTIVE: This study evaluated the relationship between adipose tissue volume and survival in patients with non-small cell lung cancer (NSCLC). METHODS: We retrospectively included 171 NSCLC patients who underwent staging 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and subsequent curative surgical resection or definite chemoradiotherapy. Maximum standardized uptake value (SUV) of lung cancer normalized by lean body mass (SULmax) and volume and mean SUV of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were derived from PET/CT images...
May 4, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29749688/effect-of-type-of-language-therapy-on-expressive-language-skills-in-patients-with-post-stroke-aphasia
#16
Jasmina Vuksanović, Tanja Milovanović, Ljubica Konstantinović, Saša R Filipović
BACKGROUND: Constraint-induced (language) aphasia therapy (CIAT), based on constraint usage of the language channel only, massed practice and shaping through therapeutic language games, has been suggested as a more efficient therapy approach than traditional aphasia therapies. AIMS: To examine the comparative efficacy of CIAT and a traditional therapy approach on expressive language ability, with the intensity of therapy controlled and matched, in the treatment of post-stroke aphasia...
May 10, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29740342/automatic-screening-for-perturbations-in-boolean-networks
#17
Julian D Schwab, Hans A Kestler
A common approach to address biological questions in systems biology is to simulate regulatory mechanisms using dynamic models. Among others, Boolean networks can be used to model the dynamics of regulatory processes in biology. Boolean network models allow simulating the qualitative behavior of the modeled processes. A central objective in the simulation of Boolean networks is the computation of their long-term behavior-so-called attractors. These attractors are of special interest as they can often be linked to biologically relevant behaviors...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29738988/use-of-mobile-applications-and-blogs-by-pregnant-women-in-turkey-and-the-impact-on-adaptation-to-pregnancy
#18
Sultan Özkan Şat, Şengül Yaman Sözbir
OBJECTIVES: This study aimed to demonstrate how the use of mobile applications and blogs impacts on a woman's pregnancy. DESIGN: This was a descriptive study. A questionnaire and the Prenatal Self Evaluation Questionnaire (PSEQ) were administered to collect the data. The PSEQ was developed to evaluate a woman's adaptation to pregnancy before labour and contained seven subscales: acceptance of pregnancy, identification of a motherhood role, relationship with her mother, relationship with her husband, preparation for labour, prenatal fear of helplessness and loss of control in labour and concern for the well-being of self and baby...
April 11, 2018: Midwifery
https://www.readbyqxmd.com/read/29738484/human-macrophages-preferentially-infiltrate-the-superficial-adipose-tissue
#19
Giuseppe Cappellano, Evi M Morandi, Johannes Rainer, Philipp Grubwieser, Katharina Heinz, Dolores Wolfram, David Bernhard, Susanne Lobenwein, Gerhard Pierer, Christian Ploner
Human abdominal subcutaneous adipose tissue consists of two individual layers—the superficial adipose tissue (SAT) and deep adipose tissue (DAT)—separated by the Scarpa’s fascia. The present study focuses on the analysis of morphological and immunological differences of primary adipocytes, adipose-derived stem cells (ASC), and tissue-infiltrating immune cells found in SAT and DAT. Adipocytes and stromal vascular fraction (SVF) cells were isolated from human SAT and DAT specimens and phenotypically characterized by in vitro assays...
May 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29727873/-utilization-of-selective-anthelmintic-therapy-on-horse-farms-in-germany
#20
Celine Simoneit, Janina McKay-Demeler, Roswitha Merle
OBJECTIVE: Deworming management is important for a good herd health status in horses. The aim of this study was to present differences between farms using a regular deworming management and a selective anthelmintic therapy approach (SAT), respectively. MATERIAL AND METHODS: An online survey was conducted to identify deworming practices on horse farms. The questionnaire included questions on the number of animals kept on the farm, housing, hygiene, and deworming practices...
April 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
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