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https://www.readbyqxmd.com/read/29786867/growth-hormone-releasing-hormone-antagonists-reduce-prostatic-enlargement-and-inflammation-in-carrageenan-induced-chronic-prostatitis
#1
Petra Popovics, Renzhi Cai, Wei Sha, Ferenc G Rick, Andrew V Schally
BACKGROUND: Inflammation plays a key role in the etiology of benign prostatic hyperplasia (BPH) through multiple pathways involving the stimulation of proliferation by cytokines and growth factors as well as the induction of the focal occurrence of epithelial-to-mesenchymal transition (EMT). We have previously reported that GHRH acts as a prostatic growth factor in experimental BPH and in autoimmune prostatitis models and its blockade with GHRH antagonists offer therapeutic approaches for these conditions...
May 21, 2018: Prostate
https://www.readbyqxmd.com/read/29786774/computational-fluid-dynamics-modeling-of-the-human-pulmonary-arteries-with-experimental-validation
#2
Alifer D Bordones, Matthew Leroux, Vitaly O Kheyfets, Yu-An Wu, Chia-Yuan Chen, Ender A Finol
Pulmonary hypertension (PH) is a chronic progressive disease characterized by elevated pulmonary arterial pressure, caused by an increase in pulmonary arterial impedance. Computational fluid dynamics (CFD) can be used to identify metrics representative of the stage of PH disease. However, experimental validation of CFD models is often not pursued due to the geometric complexity of the model or uncertainties in the reproduction of the required flow conditions. The goal of this work is to validate experimentally a CFD model of a pulmonary artery phantom using a particle image velocimetry (PIV) technique...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786762/chronic-conditions-and-multimorbidity-in-a-primary-care-population-a-study-in-the-swiss-sentinel-surveillance-network-sentinella
#3
Markus Gnädinger, Lilli Herzig, Alessandro Ceschi, Dieter Conen, Alfred Staehelin, Marco Zoller, Milo A Puhan
OBJECTIVES: To provide estimates of the prevalence of chronic conditions in Swiss primary care. METHODS: In total, 175 general practitioners (GP) or pediatricians (PED) reporting to the Swiss Sentinel Surveillance Network collected morbidity data. RESULTS: In 26,853 patient contacts, mean (± SD) age was 55.8 ± 21.6 or 6.1 ± 5.7 years (in GPs vs. PEDs, respectively) and 47% were males. In GP patients, median Thurgau Morbidity Index was 2 (IQR 1-3)...
May 21, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29785895/complexity-in-pediatric-primary-care
#4
Arwa Nasir, Laeth Nasir, Ariel Tarrell, David Finken, Amy Lacroix, Swetha Pinninti, Sheryl Pitner, Molly McCarthy
BACKGROUND: The management of patients in primary care is often complicated by the presence of multiple chronic conditions and psychosocial issues that increase the complexity of the encounter and have important impacts on care. There is a paucity of literature on this subject in the pediatric population. OBJECTIVES: The aim of this study was to quantify the burden of chronic conditions in pediatric primary care. METHODS: The problem lists of 3995 randomly selected patients from a community pediatric clinic and an academic hospital-based pediatric clinic in the same metropolitan area were analyzed for the presence and number of any chronic condition...
May 22, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29785710/insomnia-in-community-living-persons-with-advanced-age
#5
Brienne Miner, Thomas M Gill, H Klar Yaggi, Nancy S Redeker, Peter H Van Ness, Ling Han, Carlos A Vaz Fragoso
OBJECTIVE: To evaluate the epidemiology of insomnia, including demographic and clinical correlates, in older adults. DESIGN: Cross-sectional. SETTING: Community. PARTICIPANTS: Yale Precipitating Events Project participants (N=379; mean age 84.3; 67.8% female; 11.9% African American). MEASUREMENTS: Insomnia Severity Index (ISI), with scores of 8 and higher indicating insomnia, which was further stratified according to ISI score as mild (8-14), moderate (15-21), or severe (22-28)...
May 21, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29785526/education-and-physical-health-trajectories-in-later-life-a-comparative-study
#6
Liliya Leopold
The cumulative (dis)advantage hypothesis states that health disparities between education groups increase with age. The present study examined this hypothesis in a comparative analysis of the United States, the United Kingdom, the Netherlands, and Sweden. These countries offer sharp contrasts in the social conditions that may intensify or inhibit processes of cumulative (dis)advantage. Using harmonized panel data from the HRS, ELSA, and SHARE, the study applied Poisson multilevel regression models to trace changes in the number of chronic conditions and functional limitations of people aged 50-76 (N = 16,887 individuals; 71,154 observations)...
May 21, 2018: Demography
https://www.readbyqxmd.com/read/29785258/intra-articular-biomaterials-assisted-delivery-to-treat-temporomandibular-joint-disorders
#7
Khandmaa Dashnyam, Jung-Hwan Lee, Nandin Mandakhbayar, Guang-Zhen Jin, Hae-Hyoung Lee, Hae-Won Kim
The temporomandibular joint disorder, also known as myofascial pain syndrome, is considered one of the prevalent chronic pain diseases caused by muscle inflammation and cartilage degradation in head and neck, and thus influences even biopsychosocial conditions in a lifetime. There are several current treatment methodologies relieving inflammation and preventing degradation of the joint complex. One of the promising non-surgical treatment methods is an intra-articular injection of drugs such as corticosteroids, analgesics, and anti-depressants...
January 2018: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29785133/are-quantitative-histopathologic-criteria-capable-of-differentiating-psoriasis-from-chronic-dermatitis
#8
Hamid Reza Ghasemi Basir, Pedram Alirezaei, Zahra Hamian, Elham Khanlarzadeh
Background: There are overlapping features in histopathologic characteristics of psoriasis and chronic dermatitis, which sometimes make the correct diagnosis difficult. Objective: The aim of this study was to compare the histopathologic diagnostic features of psoriasis with chronic dermatitis quantitatively. Patients and methods: In this study, 30 patients with psoriasis and 30 patients with chronic dermatitis were included. Diagnosis of psoriasis or chronic dermatitis was based on clinicopathologic correlation...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29785099/comparison-of-the-effectiveness-of-complex-decongestive-therapy-and-compression-bandaging-as-a-method-of-treatment-of-lymphedema-in-the-elderly
#9
Ewa Zasadzka, Tomasz Trzmiel, Maria Kleczewska, Mariola Pawlaczyk
Background: Lymphedema is a chronic condition which significantly lowers the quality of patient life, particularly among elderly populations, whose mobility and physical function are often reduced. Objectives: The aim of the study was to compare the effectiveness of multi-layer compression bandaging (MCB) and complex decongestive therapy (CDT), and to show that MCB is a cheaper, more accessible and less labor intensive method of treating lymphedema in elderly patients...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29785096/smartphone-apps-for-improving-medication-adherence-in-hypertension-patients-perspectives
#10
Eimear C Morrissey, Monica Casey, Liam G Glynn, Jane C Walsh, Gerard J Molloy
Purpose: Digital interventions, such as smartphone applications (apps), are becoming an increasingly common way to support medication adherence and self-management in chronic conditions. It is important to investigate how patients feel about and engage with these technologies. The aim of this study was to explore patients' perspectives on smartphone apps to improve medication adherence in hypertension. Methods: This was a qualitative study based in the West of Ireland...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29785077/mediterranean-diet-and-nonalcoholic-fatty-liver-disease
#11
REVIEW
Caterina Anania, Francesco Massimo Perla, Francesca Olivero, Lucia Pacifico, Claudio Chiesa
Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease, and is characterized by a wide spectrum of fat-liver disorders that can result in severe liver disease and cirrhosis. Inflammation and oxidative stress are the major risk factors involved in the pathogenesis of NAFLD. Currently, there is no consensus concerning the pharmacological treatment of NAFLD. However, lifestyle interventions based on exercise and a balanced diet for quality and quantity, are considered the cornerstone of NAFLD management...
May 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29784950/genome-wide-association-study-identified-new-susceptible-genetic-variants-in-hla-class-i-region-for-hepatitis-b-virus-related-hepatocellular-carcinoma
#12
Hiromi Sawai, Nao Nishida, Seik-Soon Khor, Masao Honda, Masaya Sugiyama, Natsumi Baba, Kayoko Yamada, Norie Sawada, Shoichiro Tsugane, Kazuhiko Koike, Yuji Kondo, Hiroshi Yatsuhashi, Shinya Nagaoka, Akinobu Taketomi, Moto Fukai, Masayuki Kurosaki, Namiki Izumi, Jong-Hon Kang, Kazumoto Murata, Keisuke Hino, Sohji Nishina, Akihiro Matsumoto, Eiji Tanaka, Naoya Sakamoto, Koji Ogawa, Kazuhide Yamamoto, Akihiro Tamori, Osamu Yokosuka, Tatsuo Kanda, Isao Sakaida, Yoshito Itoh, Yuichiro Eguchi, Satoshi Oeda, Satoshi Mochida, Man-Fung Yuen, Wai-Kay Seto, Yong Poovorawan, Nawarat Posuwan, Masashi Mizokami, Katsushi Tokunaga
We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese and other East Asian populations. We identified 65 SNPs with P values < 10-4 located within the HLA class I region and three SNPs were genotyped in three independent population-based replication sets...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784896/measuring-and-explaining-socioeconomic-inequalities-in-public-healthcare-utilization-in-western-iran-evidence-from-a-cross-sectional-survey
#13
Shahab Rezaeian, Mohammad Hajizadeh, Satar Rezaei, Sina Ahmadi, Ali Kazemi Karyani, Yahya Salimi
BACKGROUND: Equity in healthcare utilization is a major health policy goal in all healthcare systems. This study aimed to examine socioeconomic inequalities in public healthcare utilization in Kermanshah City, western Iran. STUDY DESIGN: A cross-sectional study. METHODS: Using convenience sampling method, 2040 adult aged 18-65 yr were enrolled from Kermanshah City in 2017. A self-administrated questionnaire was used to collect data on socio-demographic characteristics, socioeconomic status, behavioral factors, and utilization of public healthcare services (inpatient and outpatient care) over the period between from May to Aug 2017...
May 14, 2018: Journal of Research in Health Sciences
https://www.readbyqxmd.com/read/29784840/oxidative-stress-and-first-line-antituberculosis-drug-induced-hepatotoxicity
#14
Wing Wai Yew, Kwok Chiu Chang, Denise P Chan
Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with significant morbidity and even rarely mortality. This form of toxicity potentially impacts the treatment outcome of tuberculosis in some patients. Confining to first-line antituberculosis drugs, this review addresses whether and how oxidative stress, and more broadly, disturbance in redox homeostasis alongside mitochondrial dysfunction, may contribute to the hepatotoxicity induced by them. Risk factors for such toxicity that have been identified, in addition to genetic factors, principally include old age, malnutrition, alcoholism, chronic hepatitis C and chronic hepatitis B infection, HIV infection and pre-existing liver disease...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29784810/chronic-sleep-curtailment-even-without-extended-16-h-wakefulness-degrades-human-vigilance-performance
#15
Andrew W McHill, Joseph T Hull, Wei Wang, Charles A Czeisler, Elizabeth B Klerman
Millions of individuals routinely remain awake for more than 18 h daily, which causes performance decrements. It is unknown if these functional impairments are the result of that extended wakefulness or from the associated shortened sleep durations. We therefore examined changes in objective reaction time performance and subjective alertness in a 32-d inpatient protocol in which participants were scheduled to wakefulness durations below 16 h while on a 20-h "day," with randomization into standard sleep:wake ratio (1:2) or chronic sleep restriction (CSR) ratio (1:3...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29784550/school-environmental-conditions-and-links-to-academic-performance-and-absenteeism-in-urban-mid-atlantic-public-schools
#16
J D Berman, M C McCormack, K A Koehler, F Connolly, D Clemons-Erby, M F Davis, C Gummerson, P J Leaf, T D Jones, F C Curriero
School facility conditions, environment, and perceptions of safety and learning have been investigated for their impact on child development. However, it is important to consider how the environment separately influences academic performance and attendance after controlling for school and community factors. Using results from the Maryland School Assessment, we considered outcomes of school-level proficiency in reading and math plus attendance and chronic absences, defined as missing 20 or more days, for grades 3-5 and 6-8 at 158 urban schools...
May 2, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29784508/il-33-mast-cell-axis-is-central-in-ll-37-induced-bladder-inflammation-and-pain-in-a-murine-interstitial-cystitis-model
#17
M Martin Jensen, Wanjian Jia, Austin J Schults, Xiangyang Ye, Glenn D Prestwich, Siam Oottamasathien
Interstitial cystitis (IC), also known as painful bladder syndrome (PBS), is a debilitating chronic condition that afflicts over 3 million women above the age of 18 in the U.S., and most patients fail to respond to current treatment options. Mast cells have previously been implicated as both a diagnostic and prognostic marker in IC/PBS. Patients with IC/PBS have been shown to have elevated levels of IL-33, a cytokine released in response to tissue insult, in their urine. We hypothesize that mast cell-mediated inflammation induced from IL-33 may play an important role in initiating pain and inflammation in IC/PBS...
May 18, 2018: Cytokine
https://www.readbyqxmd.com/read/29784119/venous-stents-current-status-and-future-directions
#18
Susan M Shamimi-Noori, Timothy W I Clark
Venous outflow obstruction is a dominant contributor to chronic venous disease. Treatment of venous disease has historically been limited by available vascular stent technology not specifically designed for the venous system. The ideal venous stent must provide requisite flexibility, strength, and accurate deployment for the anatomical and pathophysiological conditions of chronic venous disease. Venous stent technology is advancing with multiple dedicated venous stents currently available in Europe and with investigational device exemption studies ongoing in the United States...
June 2018: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29784054/systematic-literature-review-and-assessment-of-patient-reported-outcome-instruments-in-sickle-cell-disease
#19
Grammati Sarri, Menaka Bhor, Seye Abogunrin, Caroline Farmer, Savita Nandal, Rashid Halloway, Dennis A Revicki
BACKGROUND: Sickle cell disease (SCD) is a chronic condition associated with high mortality and morbidity. It is characterized by acute clinical symptoms such as painful vaso-occlusive crises, which can impair health-related quality of life (HRQL). This study was conducted to identify validated patient-reported outcome (PRO) instruments for use in future trials of potential treatments for SCD. METHODS: A systematic literature review (SLR) was performed using MEDLINE and EMBASE to identify United States (US)-based studies published in English between 1997 and 2017 that reported on validated PRO instruments used in randomized controlled trials and real-world settings...
May 21, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29783959/soluble-urokinase-plasminogen-activator-receptor-predicts-mortality-in-exacerbated-copd
#20
Nina S Godtfredsen, Ditte V Jørgensen, Kristoffer Marsaa, Charlotte S Ulrik, Ove Andersen, Jesper Eugen-Olsen, Line J H Rasmussen
BACKGROUND: The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suPAR in predicting risk of death following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has never been studied. We hypothesized that increased suPAR is an independent predictor of short-term mortality in patients admitted to hospital with COPD or acute respiratory failure...
May 21, 2018: Respiratory Research
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