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https://www.readbyqxmd.com/read/28511261/current-practice-and-the-future-of-deep-brain-stimulation-therapy-in-parkinson-s-disease
#1
Leonardo Almeida, Wissam Deeb, Chauncey Spears, Enrico Opri, Rene Molina, Daniel Martinez-Ramirez, Aysegul Gunduz, Christopher W Hess, Michael S Okun
Deep brain stimulation (DBS) is an effective therapy for Parkinson's disease patients experiencing motor fluctuations, medication-resistant tremor, and/or dyskinesia. Currently, the subthalamic nucleus and the globus pallidus internus are the two most widely used targets, with individual advantages and disadvantages influencing patient selection. Potential DBS patients are selected using the few existing guidelines and the available DBS literature, and many centers employ an interdisciplinary team review of the individual's risk-benefit profile...
April 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28499260/metal-toxicity-affects-predatory-stream-invertebrates-less-than-other-functional-feeding-groups
#2
Matthias Liess, Nadine V Gerner, Ben J Kefford
Ecosystem effects of heavy metals need to be identified for a retrospective risk assessment, and potential impacts need to be predicted for a prospective risk assessment. In this study, we established a strong correlation between the toxic pressure of dissolved metals and invertebrate species. We compiled available data from a wide geographical range of Australian streams that were contaminated with heavy metals [mainly copper (Cu) and zinc (Zn)] and the corresponding invertebrate communities. Heavy metal toxicity is positively related to the proportion of predators within the invertebrate community, represented by the predatorratio, with an effect threshold range of 2...
May 9, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28481271/mb0-and-mbi-are-independent-and-distinct-transactivation-domains-in-myc-that-are-essential-for-transformation
#3
Qin Zhang, Kimberly West-Osterfield, Erick Spears, Zhaoliang Li, Alexander Panaccione, Stephen R Hann
MYC is a transcription factor that is essential for cellular proliferation and development. Deregulation or overexpression of MYC occurs in a variety of human cancers. Ectopic expression of MYC causes hyperproliferation and transformation of cells in culture and tumorigenesis in several transgenic mouse models. Deregulation of MYC can also induce apoptosis through activation of p53 and/or ARF tumor suppressors as a safeguard to prevent tumorigenesis. MYC binds to thousands of genomic sites and regulates hundreds of target genes in a context-dependent fashion to mediate these diverse biological roles...
May 6, 2017: Genes
https://www.readbyqxmd.com/read/28480299/the-2-8%C3%A2-%C3%A3-electron-microscopy-structure-of-adeno-associated-virus-dj-bound-by-a-heparinoid-pentasaccharide
#4
Qing Xie, John M Spear, Alex J Noble, Duncan R Sousa, Nancy L Meyer, Omar Davulcu, Fuming Zhang, Robert J Linhardt, Scott M Stagg, Michael S Chapman
Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux, have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy vector, AAV-DJ, is a hybrid of natural serotypes that was previously derived by directed evolution, selecting for hepatocyte entry and resistance to neutralization by human serum. The structure of AAV-DJ differs from that of parental serotypes in two regions where neutralizing antibodies bind, so immune escape appears to have been the primary driver of AAV-DJ's directed evolution...
June 16, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28476435/a-multi-institutional-analysis-of-trimodality-therapy-for-esophageal-cancer-in-elderly-patients
#5
Scott C Lester, Steven H Lin, Michael Chuong, Neha Bhooshan, Zhongxing Liao, Andrea L Arnett, Sarah E James, Jaden D Evans, Grant M Spears, Ritsuko Komaki, Michael G Haddock, Minesh P Mehta, Christopher L Hallemeier, Kenneth W Merrell
PURPOSE: The therapeutic gains of neoadjuvant chemoradiation therapy (nCRT) followed by esophagectomy may be offset by increased incidences of morbidity and mortality in elderly patients. This study aimed to determine the impact of age on the risks and benefits of trimodality therapy for esophageal cancer. METHODS AND MATERIALS: We evaluated 571 patients treated with trimodality therapy at 3 high-volume tertiary cancer centers in the United States from 2007 to 2013...
February 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28452163/3d-printed-transparent-glass
#6
Du T Nguyen, Cameron Meyers, Timothy D Yee, Nikola A Dudukovic, Joel F Destino, Cheng Zhu, Eric B Duoss, Theodore F Baumann, Tayyab Suratwala, James E Smay, Rebecca Dylla-Spears
Silica inks are developed, which may be 3D printed and thermally processed to produce optically transparent glass structures with sub-millimeter features in forms ranging from scaffolds to monoliths. The inks are composed of silica powder suspended in a liquid and are printed using direct ink writing. The printed structures are then dried and sintered at temperatures well below the silica melting point to form amorphous, solid, transparent glass structures. This technique enables the mold-free formation of transparent glass structures previously inaccessible using conventional glass fabrication processes...
April 28, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28450433/differentiation-of-enhancing-glioma-and-primary-central-nervous-system-lymphoma-by-texture-based-machine-learning
#7
P Alcaide-Leon, P Dufort, A F Geraldo, L Alshafai, P J Maralani, J Spears, A Bharatha
BACKGROUND AND PURPOSE: Accurate preoperative differentiation of primary central nervous system lymphoma and enhancing glioma is essential to avoid unnecessary neurosurgical resection in patients with primary central nervous system lymphoma. The purpose of the study was to evaluate the diagnostic performance of a machine-learning algorithm by using texture analysis of contrast-enhanced T1-weighted images for differentiation of primary central nervous system lymphoma and enhancing glioma...
April 27, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28446618/the-role-of-feeding-morphology-and-competition-in-governing-the-diet-breadth-of-sympatric-stomatopod-crustaceans
#8
Maya S deVries
Competition for food drives divergence and specialization in feeding morphology. Stomatopod crustaceans have two kinds of highly specialized feeding appendages: either elongate spear-like appendages (spearers) used to ambush soft-bodied evasive prey or hammer-like appendages (smashers) that produce extremely high forces used both to break hard-shelled prey and to capture evasive prey. To evaluate associations between appendage type and feeding ecology, the diet of two small smasher and spearer species (size range: 21-27 mm) that co-occur were compared...
April 2017: Biology Letters
https://www.readbyqxmd.com/read/28442264/mitochondrial-lon-protease-dependent-degradation-of-cytochrome-c-oxidase-subunits-under-hypoxia-and-myocardial-ischemia
#9
Naresh B V Sepuri, Rajesh Angireddy, Satish Srinivasan, Manti Guha, Joseph Spear, Bin Lu, Hindupur K Anandatheerthavarada, Carolyn K Suzuki, Narayan G Avadhani
The mitochondrial ATP dependent matrix protease, Lon, is involved in the maintenance of mitochondrial DNA nucleoids and degradation of abnormal or misfolded proteins. The Lon protease regulates mitochondrial Tfam (mitochondrial transcription factor A) level and thus modulates mitochondrial DNA (mtDNA) content. We have previously shown that hypoxic stress induces the PKA-dependent phosphorylation of cytochrome c oxidase (CcO) subunits I, IVi1, and Vb and a time-dependent reduction of these subunits in RAW 264...
April 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28439629/transitioning-to-the-direct-anterior-approach-in-total-hip-arthroplasty-is-it-a-true-muscle-sparing-approach-when-performed-by-a-low-volume-hip-replacement-surgeon
#10
Dan-Viorel Nistor, Sergiu Caterev, Sorana-Daniela Bolboacă, Dan Cosma, Dan Osvald Gheorghe Lucaciu, Adrian Todor
PURPOSE: We conducted this study to establish if the transition from a lateral approach (LA) to the direct anterior approach (DAA) for a low volume hip arthroplasty surgeon during the steep learning curve can be performed maintaining the muscle sparing approach of the DAA without increasing the complication rates. METHODS: In this controlled, prospective, randomized clinical study we investigated 70 patients (35 DAA, 35 LA) with similar demographics that underwent a total hip arthroplasty...
April 24, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28435334/bispectral-index-value-correlates-with-glasgow-coma-scale-in-traumatic-brain-injury-patients
#11
Tjokorda Gde Agung Senapathi, Made Wiryana, I Gusti Ngurah Mahaalit Aribawa, Christopher Ryalino
BACKGROUND: Accuracy of consciousness level assessment is very important. It may determine and influence further clinical decisions, thus influences patients' outcomes. The widest method in determining the level of awareness is the Glasgow Coma Scale (GCS). Despite its common use, GCS scores obtained by one clinician may differ from others depending on their interpretations and past experience. One of the tools used to assess the level of consciousness objectively is bispectral index (BIS)...
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/28427908/transforming-the-health-care-experience-doctors-nurses-patients-and-beyond
#12
Trina Spear, Karen M Horton, Elliot K Fishman, Pamela T Johnson
No abstract text is available yet for this article.
April 17, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28416816/scalable-electrophysiology-in-intact-small-animals-with-nanoscale-suspended-electrode-arrays
#13
Daniel L Gonzales, Krishna N Badhiwala, Daniel G Vercosa, Benjamin W Avants, Zheng Liu, Weiwei Zhong, Jacob T Robinson
Electrical measurements from large populations of animals would help reveal fundamental properties of the nervous system and neurological diseases. Small invertebrates are ideal for these large-scale studies; however, patch-clamp electrophysiology in microscopic animals typically requires invasive dissections and is low-throughput. To overcome these limitations, we present nano-SPEARs: suspended electrodes integrated into a scalable microfluidic device. Using this technology, we have made the first extracellular recordings of body-wall muscle electrophysiology inside an intact roundworm, Caenorhabditis elegans...
April 17, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28409837/clinical-accuracy-of-preoperative-breast-mri-for-breast-cancer
#14
Jennifer Tseng, Alexandra Kyrillos, Erik Liederbach, Georgia G Spear, Jacob Ecanow, Chi-Hsiung Wang, Tom Czechura, Olga Kantor, Megan Miller, David J Winchester, Catherine E Pesce, Sarah Rabbitt, Katharine Yao
BACKGROUND: It is unclear if breast magnetic resonance imaging (MRI) is more accurate than mammography (MGM) and ultrasound (U/S) in aggregate for patients with invasive cancer. METHODS: We compared concordance of combined tumor size and tumor foci between MRI and MGM and U/S combined to pathological tumor size and foci as the gold standard from 2009 to 2015. Tumor size was nonconcordant if it differed from the pathologic size by ≥33% and tumor foci was nonconcordant if >1 foci were seen...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28388915/improved-curdlan-production-with-discarded-bottom-parts-of-asparagus-spear
#15
Rex Frimpong Anane, Huifang Sun, Lamei Zhao, Le Wang, Chun Lin, Zichao Mao
BACKGROUND: This work evaluated the improvement of curdlan production of Agrobacterium sp. ATCC 31749 by using culture medium containing juice of discarded bottom part of green Asparagus spear (MJDA). Curdlan production was carried out using Agrobacterium sp. ATCC 31749 in flasks with different volumes of MJDA and its non-juice-adding control (CK) incubated in shaker at 30 °C, 200 rpm rotation for 168 h. RESULTS: All MJDA media increased Agrobacterium sp. ATCC 31749 cell mass and enhanced the cells' ability to utilise sucrose, the carbon source for curdlan biosynthesis, and thereby produced higher concentration of curdlan than CK which is used for commercial production of curdlan...
April 7, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28382664/patterns-in-vegetable-consumption-implications-for-tailored-school-meal-interventions
#16
Marietta Orlowski, Miryoung Lee, William Spears, Roopsi Narayan, Rebecca S Pobocik, Julie Kennel, Erin Krafka, Susan Patton
BACKGROUND: Vegetable consumption is a challenging behavioral target; consumption rates are below recommended levels and when interventions produce improvements, increases in vegetable consumption are typically a fraction of the change in fruit consumption. We describe vegetable consumption within Ohio school meals and examine how fruit selection, the more popular item, impacts vegetable consumption. METHODS: Fruit and vegetable waste was collected on 11,250 trays from 17 elementary and 16 middle/high schools, using the quarter-waste visualization method...
May 2017: Journal of School Health
https://www.readbyqxmd.com/read/28381571/discovery-of-novel-small-molecule-inhibitors-of-lim-domain-kinase-for-inhibiting-hiv-1
#17
Fei Yi, Jia Guo, Deemah Dabbagh, Mark Spear, Sijia He, Kylene Kehn-Hall, Jacque Fontenot, Yan Yin, Mathieu Bibian, Chul Min Park, Ke Zheng, HaJeung Park, Veronica Soloveva, Dima Gharaibeh, Cary Retterer, Rouzbeh Zamani, Margaret L Pitt, John Naughton, Yongjun Jiang, Hong Shang, Ramin M Hakami, Binhua Ling, John A T Young, Sina Bavari, Xuehua Xu, Yangbo Feng, Yuntao Wu
A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity through hijacking chemokine coreceptor signaling which activates a host dependency factor cofilin and its kinase, the LIM domain kinase (LIMK). Although knockdown of human LIMK1 with shRNA inhibits HIV infection, no specific small molecule inhibitor of LIMK was available. Here we describe the design and discovery of novel classes of small molecule inhibitors of LIMK for inhibiting HIV infection...
April 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28377391/dietary-assessment-of-british-police-force-employees-a-description-of-diet-record-coding-procedures-and-cross-sectional-evaluation-of-dietary-energy-intake-reporting-the-airwave-health-monitoring-study
#18
Rachel Gibson, Rebeca Eriksen, Kathryn Lamb, Yvonne McMeel, Anne-Claire Vergnaud, Jeanette Spear, Maria Aresu, Queenie Chan, Paul Elliott, Gary Frost
OBJECTIVES: Dietary intake is a key aspect of occupational health. To capture the characteristics of dietary behaviour that is affected by occupational environment that may affect disease risk, a collection of prospective multiday dietary records is required. The aims of this paper are to: (1) collect multiday dietary data in the Airwave Health Monitoring Study, (2) describe the dietary coding procedures applied and (3) investigate the plausibility of dietary reporting in this occupational cohort...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28377298/environmental-enrichment-choices-of-shelter-cats
#19
J J Ellis, H Stryhn, J Spears, M S Cockram
Choices made by cats between different types of environmental enrichment may help shelters to prioritize how to most effectively enrich cat housing, especially when limited by space or funds. This study investigates the environmental enrichment use of cats in a choice test. Twenty-six shelter cats were kept singularly in choice chambers for 10 days. Each chamber had a central area and four centrally-linked compartments containing different types of environmental enrichment: 1) an empty control, 2) a prey-simulating toy, 3) a perching opportunity, and 4) a hiding opportunity...
April 1, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28363690/an-update-of-the-american-urological-association-white-paper-on-the-prevention-and-treatment-of-the-more-common-complications-related-to-prostate-biopsy
#20
Michael A Liss, Behfar Ehdaie, Stacy Loeb, Maxwell V Meng, Jay D Raman, Vanessa Spears, Sean P Stroup
PURPOSE: In this white paper update we identify and discuss the prevalence and prevention of common complications of prostate needle biopsy. MATERIALS AND METHODS: A literature review was performed on prostate biopsy complications via queries of PubMed and Embase databases for prostate biopsy complications from January 1, 2010 until June 1, 2015. We focused on infection, bleeding, urinary retention, needle tract seeding and erectile dysfunction. A total of 346 articles were identified for full text review and 119 are included in the final data synthesis...
March 29, 2017: Journal of Urology
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