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JOURNAL ARTICLE
Hamza Salim, Basel Musmar, Nimer Adeeb, Vivek Yedavalli, Dhairya Lakhani, Sahibjot Singh Grewal, Kareem El Naamani, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kühn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Benjamin Yq Tan, Robert W Regenhardt, Jeremy J Heit, Nicole M Cancelliere, Joshua D Bernstock, Aymeric Rouchaud, Jens Fiehler, Sunil Sheth, Ajit S Puri, Christian Dyzmann, Marco Colasurdo, Xavier Barreau, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Răzvan Alexandru Radu, Mohamad Abdalkader, Piers Klein, Thomas R Marotta, Julian Spears, Takahiro Ota, Ashkan Mowla, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E Siegler, Thanh N Nguyen, Ricardo Varela, Amanda Baker, Muhammed Amir Essibayi, David Altschul, Nestor R Gonzalez, Markus A Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Mohammad Ali Aziz-Sultan, Constantin Hecker, Hamza Shaikh, David S Liebeskind, Alessandro Pedicelli, Andrea M Alexandre, Illario Tancredi, Tobias D Faizy, Erwah Kalsoum, Boris Lubicz, Aman B Patel, Vitor Mendes Pereira, Adrien Guenego, Adam A Dmytriw
BACKGROUND: Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients with distal medium vessel occlusions (DMVO) are not well understood. METHODS: This retrospective analysis involved 1282 acute ischemic stroke (AIS) patients who underwent MT in 37 centers across North America, Asia, and Europe from September 2017 to July 2023...
May 10, 2024: European Stroke Journal
#2
JOURNAL ARTICLE
Afra Alfalahi, Abdelsimar Il Omar, Krystal Fox, Julian Spears, Malika Sharma, Aditya Bharatha, David G Munoz, Suradech Suthiphosuwan
Epstein-Barr virus, a herpesvirus, has been associated with a variety of cancers, including Burkitt, Hodgkin, and non-Hodgkin lymphomas; posttransplant lymphoproliferative disorders; gastric carcinoma; and nasopharyngeal carcinoma, in both immunocompetent and immunocompromised individuals. Previous studies have established a connection between Epstein-Barr virus and the development of smooth-muscle tumors. Smooth-muscle tumors of the brain are very rare and are often misdiagnosed as meningiomas on imaging. To our knowledge, advanced imaging findings such as MR perfusion of smooth-muscle tumors of the brain have never been reported...
May 9, 2024: AJNR. American Journal of Neuroradiology
#3
Paola Algeri, Laura Colonna, Silvia Bergamelli, Laura Imbruglia, Nunzia Mastrocola, Silvia Von Wunster
OBJECTIVE: In case of uterine prolapse, hyseroxacropexy, a conservative surgical approach, which allows the sparing of body image and sexuality, could be the choice in fertile women. Few information are reported on subsequent pregnancy after surgery. CASE REPORT: A 33 years-old women with symptomatic prolapse underwent a laparoscopic hysterosacropexy. Subsequently she expressed her pregnancy desire and she got pregnant. A scheduled caesarean section was performed without complication...
September 2023: Journal of Family & Reproductive Health
#4
JOURNAL ARTICLE
Joe Spearing
I investigate heterogeneity across occupational characteristics in the effect of retirement eligibility on mental health in the United Kingdom. I use K-means clustering to define three occupational clusters, differing across multiple dimensions. I estimate the effect of retirement eligibility using a Regression Discontinuity Design, allowing the effect to differ by cluster. The effects of retirement eligibility are beneficial, and greater in two clusters: one comprised of white-collar jobs in an office setting and another of blue-collar jobs with high physical demands and hazards...
May 4, 2024: Health Economics
#5
JOURNAL ARTICLE
Jose Danilo Bengzon Diestro, Nimer Adeeb, Basel Musmar, Hamza Salim, Assala Aslan, Nicole M Cancelliere, Rachel M McLellan, Oktay Algin, Sherief Ghozy, Sovann V Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Kevin Premat, Markus Möhlenbruch, Michael Kral, Joshua D Bernstock, Omer Doron, Charlotte Chung, Mohamed M Salem, Ivan Lylyk, Paul M Foreman, Jay A Vachhani, Hamza Shaikh, Vedran Župančić, Muhammad U Hafeez, Joshua Catapano, Muhammad Waqas, Mohamed K Ibrahim, Marwa A Mohammed, Cetin Imamoglu, Ahmet Bayrak, James D Rabinov, Yifan Ren, Clemens M Schirmer, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Stéphanie Elens, Robert M Starke, Ameer E Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Muhammed Amir Essibayi, Sunil A Sheth, Gary Spiegel, Rabih G Tawk, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Erez Nossek, Eytan Raz, Monika Killer-Oberpfalzer, Christoph J Griessenauer, Hamed Asadi, Adnan Siddiqui, Allan L Brook, David Altschul, Julian Spears, Thomas R Marotta, Andrew F Ducruet, Felipe C Albuquerque, Robert W Regenhardt, Christopher J Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Mohammad A Aziz-Sultan, Stavropoula I Tjoumakaris, Pascal M Jabbour, Frédéric Clarençon, Nicola Limbucci, Hugo H Cuellar-Saenz, Vitor Mendes Pereira, Aman B Patel, Adam A Dmytriw
OBJECTIVE: This study was conducted to investigate the impact of antiplatelet administration in the periprocedural period on the occurrence of thromboembolic complications (TECs) in patients undergoing treatment using the Woven EndoBridge (WEB) device for intracranial wide-necked bifurcation aneurysms. The primary objective was to assess whether the use of antiplatelets in the pre- and postprocedural phases reduces the likelihood of developing TECs, considering various covariates. METHODS: A retrospective multicenter observational study was conducted within the WorldWideWEB Consortium and comprised 38 academic centers with endovascular treatment capabilities...
May 3, 2024: Journal of Neurosurgery
#6
REVIEW
Jin Zhao, Meijing Zheng, Li Ma, Tao Guan, Liping Su
Multiple myeloma (MM), marked by abnormal proliferation of plasma cells and production of monoclonal immunoglobulin heavy or light chains in the majority of patients, has traditionally been associated with poor survival, despite improvements achieved in median survival in all age groups since the introduction of novel agents. Survival has significantly improved with the development of new drugs and new treatment options, such as chimeric antigen receptor T-cell therapy (CAR-T), which have shown promise and given new hope in MM therapy...
May 15, 2024: Heliyon
#7
JOURNAL ARTICLE
Arturo Consoli, Nicole M Cancelliere, Guillaume Charbonnier, Hidehisa Nishi, Irene Vanek, Thomas R Marotta, Julian Spears, Vitor M Pereira
BACKGROUND: Pulsatile tinnitus (PT) can be a disabling clinical condition, which may be caused by a sigmoid/transverse sinus stenosis (STSS). Intracranial venous stenting with off-label carotid or peripheral venous stents has been used successfully to treat this condition. We present the results of a cohort of patients presenting with PT treated with a novel, dedicated, braided stent for the endovascular treatment of STSS. METHODS: Twelve patients presenting with PT and associated STSS were treated at our institution (December 2022-June 2023)...
May 2, 2024: Journal of Neurointerventional Surgery
#8
JOURNAL ARTICLE
G Dumas, A Danjou, C Richaud, R Spear, M Joly, S Blaise
AIM: The treadmill walking test with post-exercise pressure measurement can be used as a diagnostic test and could classify peripheral arterial disease of the lower limbs. It can also exclude the diagnosis allowing to raise the possibility of differential diagnoses. In this study, we assessed the feasibility of performing treadmill test by advanced practice nurse to assess suspected lower extremity peripheral artery disease patients. DESIGN AND METHOD: This is a longitudinal monocentric study to assess the feasibility of a treadmill walking test performed by an advanced practice nurse...
April 2024: Journal de Médecine Vasculaire
#9
JOURNAL ARTICLE
Yufan Wu, Rujing Chen, Shuting Ni, Kaili Hu
The treatment dilemma of triple-negative breast cancer (TNBC) revolves around drug resistance and metastasis. Cancer-associated fibroblasts (CAFs) contribute to cisplatin (Cis) resistance and further metastasis in TNBC, making TNBC become a difficult-to-treat disease. The dense stromal barrier which restricts drug delivery, invasive phenotype of tumor cells, and immunosuppressive tumor microenvironment (TME) induced by CAFs serve as three "shields" for TNBC against Cis therapy. Here, we designed a silybin-loaded biomimetic nanoparticle coated with anisamide-modified red blood cell membrane (ARm@SNP) as a "nanospear" for CAFs-targeting, which could shatter the "shields" and significantly exhibit inhibitory effect on 4 T1 cells in combination with Cis both in vitro and in vivo...
April 30, 2024: Journal of Controlled Release
#10
JOURNAL ARTICLE
Scoty Hearst, Pedro M Palermo, Douglas M Watts, Kamen Campbell, Ryan Ivey, Caleb Young, William Yarbrough, Edward Facundus, Jack Spears, Stephen Mills, Kaitlin A McNeely, Priya Ray, Grace C Burnett, George T Bates, John T Bates
Background: Early detection and monitoring of SARS-CoV-2 infections in animal populations living in close proximity to humans is crucial for preventing reverse zoonosis of new viral strains. Evidence accumulated has revealed widespread SARS-CoV-2 infection among white-tailed deer (WTD), ( Odocoileus virginianus ) populations in the United States except in the southeast region. Therefore, the objective was to conduct surveillance for evidence of SARS-CoV-2 infection among WTD in Mississippi. Materials and Methods: Blood, kidney tissues, and nasal swab samples were collected in 17 counties from hunter-harvested deer during 2021-2022 and 2022-2023...
May 2, 2024: Vector Borne and Zoonotic Diseases
#11
JOURNAL ARTICLE
Satish Geeri, Aditya Kolakoti, Olusegun David Samuel, Mohamed Abbas, Peter Alenoghena Aigba, Habeeb A Ajimotokan, Christopher C Enweremadu, Noureddine Elboughdiri, M A Mujtaba
The performance of a Pelton wheel is influenced by the jet created by the nozzle. Therefore, a Computational Fluid Dynamics (CFD) simulation was proposed. In this study, the significant output parameters (outlet velocity, outlet pressure, and tangential force component) and input parameters (different pressure and spear locations) were examined. In addition, the influencing parameters and their contributing percentages to the performance of the Pelton wheel were calculated using different optimisation techniques such as Taguchi Design of Experiments (DoE), Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS), Grey Relational Analysis (GRA) and Criteria Importance Through Intercriteria Correlation (CRITIC)...
April 30, 2024: Heliyon
#12
JOURNAL ARTICLE
Isabel Goñi, Alejandra García-Alonso, Claudio Alba, Juan Miguel Rodríguez, María Cortes Sánchez-Mata, Rafael Guillén-Bejarano, Araceli Redondo-Cuenca
Asparagus is a healthy food appreciated for its organoleptic characteristics, nutritional composition and physiological properties. During its industrial processing, a large amount of by-products are generated, since only the apical part of the vegetable is considered edible and a large amount of by-products are generated that could be of nutritional interest. Therefore, the nutritional composition of the edible part and the two by-products of the plant (root and stem) was evaluated, including dietary fiber, inulin, low-molecular-weight carbohydrates, low-molecular-weight polyphenols and macromolecular polyphenols...
April 10, 2024: Foods (Basel, Switzerland)
#13
JOURNAL ARTICLE
Michael J Spear, Brandon S Harris, Taylor A Bookout, Brian S Ickes, Kathi Jo Jankowski, Levi E Solomon, Kristopher A Maxson, Andrya L Whitten, Andrew T Mathis, Sam J Schaick, Jesse A Williams, Jason A DeBoer, Allison W Lenaerts, Eric C Hine, John H Chick, James T Lamer
Rivers are increasingly used as superhighways for the continental-scale transportation of freight goods, but the ecological impact of large vessel traffic on river ecosystems is difficult to study. Recently, the temporary maintenance closure of lock and dam systems on the Illinois Waterway (USA) brought commercial vessel traffic to a halt along the river's length, offering a rare opportunity to study the response of the ecosystem before, during, and after an extended pause of this persistent anthropogenic disturbance...
April 24, 2024: Science of the Total Environment
#14
JOURNAL ARTICLE
Taleen A MacArthur, Julie Goswami, Sergio M Navarro, Sreeparna Vappala, Chanel C La, Nikoli Yudin, John Zietlow, Stephanie A Smith, James H Morrissey, Grant M Spears, Kent R Bailey, Jing-Fei Dong, Rosemary A Kozar, Jayachandran N Kizhakkedathu, Myung S Park
BACKGROUND: Inorganic polyphosphate (polyP) is a procoagulant polyanion. We assessed the impact of polyP inhibition on thrombin generation after trauma using the novel polyP antagonists, macromolecular polyanion inhibitor 8 (MPI 8) and universal heparin reversal agent 8 (UHRA-8). METHODS: Plasma thrombin generation (calibrated automated thrombogram, CAT), in 56 trauma patients and 39 controls +/- MPI 8 and UHRA-8 (50 μg/mL), was expressed as lag time (LT, minutes), peak height (PH, nM), and time to peak (ttPeak, minutes), with change in LT (ΔLT) and change in ttPeak (ΔttPeak) quantified...
March 25, 2024: Shock
#15
JOURNAL ARTICLE
Shota Hosono, Yoshio Masuda, Shun Tokioka, Tomohiko Kawamura, Yoko Iwata
Alternative reproductive tactics (ARTs) are discontinuous phenotypes associated with reproduction, observed in males of many species. Typically, large males adopt a tactic of competing with rivals for mating, while small males adopt a tactic of stealing fertilization opportunities from the large males. The 'birth date hypothesis', proposing that the date of birth influences the determination of each male's reproductive tactic, has been tested only in teleost fish to date. Here, the birth date hypothesis was tested in ARTs of Japanese spear squid Heterololigo bleekeri (consort/sneaker) by analysing statolith growth increments...
April 30, 2024: Proceedings. Biological Sciences
#16
Benjamin J LaFrance, Andrew M Ray, Robert N Fisher, Evan H Campbell Grant, Charles Shafer, David A Beamer, Stephen F Spear, Todd W Pierson, Jon M Davenport, Matthew L Niemiller, R Alexander Pyron, Brad M Glorioso, William J Barichivich, Brian J Halstead, Kory G Roberts, Blake R Hossack
No abstract text is available yet for this article.
April 22, 2024: Scientific Data
#17
JOURNAL ARTICLE
Sierra Spears, Ciara Pettit, Sophie Berkowitz, Simone Collier, Cece Colwell, Ethan H Livingston, Wyatt McQueen, Princeton L Vaughn, Brooke L Bodensteiner, Vianey Leos-Barajas, Eric J Gangloff
No abstract text is available yet for this article.
April 19, 2024: Journal of Thermal Biology
#18
JOURNAL ARTICLE
Amy G Johnson, Bethany R Rohr
Carpet beetle larvae of the family Dermestidae have been documented to cause both acute and delayed hypersensitivity reactions in susceptible individuals. These larvae have specialized horizontal rows of spear-shaped hairs called hastisetae, which detach easily into the surrounding environment and are small enough to travel by air. Exposure to hastisetae has been tied to adverse effects ranging from dermatitis to rhinoconjunctivitis and acute asthma, with treatment being mostly empiric and symptom based. Due to the pervasiveness of carpet beetles in homes, improved awareness of dermestid-induced manifestations is valuable for clinicians...
March 2024: Cutis; Cutaneous Medicine for the Practitioner
#19
Keiramarie Robertson, Oliver Hahn, Beatriz G Robinson, Arwa T Faruk, Mathangi Janakiraman, Hong Namkoong, Kwangkon Kim, Jiayu Ye, Estelle Spear Bishop, Randy A Hall, Tony Wyss-Coray, Laren S Becker, Julia A Kaltschmidt
The enteric nervous system (ENS) is contained within two layers of the gut wall and is made up of neurons, immune cells, and enteric glia cells (EGCs) that regulate gastrointestinal (GI) function. EGCs in both inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) change in response to inflammation, referred to as reactive gliosis. Whether EGCs restricted to a specific layer or region within the GI tract alone can influence intestinal immune response is unknown. Using bulk RNA-sequencing and in situ hybridization, we identify G-protein coupled receptor Gpr37 , as a gene expressed only in EGCs of the myenteric plexus, one of the two layers of the ENS...
April 12, 2024: bioRxiv
#20
Barbara Y H Cervantes, Samuel E Gavor, Nuna E Jiagge, Duniesky M Lopez, Radisnay G Lambert, Fernando M Almaguer Acevedo
Impalement injuries happen when an object penetrates a body cavity or organ and remains in situ. We present a case of a 35-year-old fisherman whose act of violence resulted in the lodging of an antique iron spear in segment V of the liver, which was then referred to our institution on the day after the accident. Despite the challenges posed by patient transfer, diagnosis, resuscitation, and, most importantly, handling in the operating room, the object was successfully removed via hepatotomy, and the patient is now in good health...
April 2024: Journal of Surgical Case Reports
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