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https://www.readbyqxmd.com/read/28427908/transforming-the-health-care-experience-doctors-nurses-patients-and-beyond
#1
Trina Spear, Karen M Horton, Elliot K Fishman, Pamela T Johnson
No abstract text is available yet for this article.
April 17, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28416816/scalable-electrophysiology-in-intact-small-animals-with-nanoscale-suspended-electrode-arrays
#2
Daniel L Gonzales, Krishna N Badhiwala, Daniel G Vercosa, Benjamin W Avants, Zheng Liu, Weiwei Zhong, Jacob T Robinson
Electrical measurements from large populations of animals would help reveal fundamental properties of the nervous system and neurological diseases. Small invertebrates are ideal for these large-scale studies; however, patch-clamp electrophysiology in microscopic animals typically requires invasive dissections and is low-throughput. To overcome these limitations, we present nano-SPEARs: suspended electrodes integrated into a scalable microfluidic device. Using this technology, we have made the first extracellular recordings of body-wall muscle electrophysiology inside an intact roundworm, Caenorhabditis elegans...
April 17, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28409837/clinical-accuracy-of-preoperative-breast-mri-for-breast-cancer
#3
Jennifer Tseng, Alexandra Kyrillos, Erik Liederbach, Georgia G Spear, Jacob Ecanow, Chi-Hsiung Wang, Tom Czechura, Olga Kantor, Megan Miller, David J Winchester, Catherine E Pesce, Sarah Rabbitt, Katharine Yao
BACKGROUND: It is unclear if breast magnetic resonance imaging (MRI) is more accurate than mammography (MGM) and ultrasound (U/S) in aggregate for patients with invasive cancer. METHODS: We compared concordance of combined tumor size and tumor foci between MRI and MGM and U/S combined to pathological tumor size and foci as the gold standard from 2009 to 2015. Tumor size was nonconcordant if it differed from the pathologic size by ≥33% and tumor foci was nonconcordant if >1 foci were seen...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28388915/improved-curdlan-production-with-discarded-bottom-parts-of-asparagus-spear
#4
Rex Frimpong Anane, Huifang Sun, Lamei Zhao, Le Wang, Chun Lin, Zichao Mao
BACKGROUND: This work evaluated the improvement of curdlan production of Agrobacterium sp. ATCC 31749 by using culture medium containing juice of discarded bottom part of green Asparagus spear (MJDA). Curdlan production was carried out using Agrobacterium sp. ATCC 31749 in flasks with different volumes of MJDA and its non-juice-adding control (CK) incubated in shaker at 30 °C, 200 rpm rotation for 168 h. RESULTS: All MJDA media increased Agrobacterium sp. ATCC 31749 cell mass and enhanced the cells' ability to utilise sucrose, the carbon source for curdlan biosynthesis, and thereby produced higher concentration of curdlan than CK which is used for commercial production of curdlan...
April 7, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28382664/patterns-in-vegetable-consumption-implications-for-tailored-school-meal-interventions
#5
Marietta Orlowski, Miryoung Lee, William Spears, Roopsi Narayan, Rebecca S Pobocik, Julie Kennel, Erin Krafka, Susan Patton
BACKGROUND: Vegetable consumption is a challenging behavioral target; consumption rates are below recommended levels and when interventions produce improvements, increases in vegetable consumption are typically a fraction of the change in fruit consumption. We describe vegetable consumption within Ohio school meals and examine how fruit selection, the more popular item, impacts vegetable consumption. METHODS: Fruit and vegetable waste was collected on 11,250 trays from 17 elementary and 16 middle/high schools, using the quarter-waste visualization method...
May 2017: Journal of School Health
https://www.readbyqxmd.com/read/28381571/discovery-of-novel-small-molecule-inhibitors-of-lim-domain-kinase-for-inhibiting-hiv-1
#6
Fei Yi, Jia Guo, Deemah Dabbagh, Mark Spear, Sijia He, Kylene Kehn-Hall, Jacque Fontenot, Yan Yin, Mathieu Bibian, Chul Min Park, Ke Zheng, HaJeung Park, Veronica Soloveva, Dima Gharaibeh, Cary Retterer, Rouzbeh Zamani, Margaret L Pitt, John Naughton, Yongjun Jiang, Hong Shang, Ramin M Hakami, Binhua Ling, John A T Young, Sina Bavari, Xuehua Xu, Yangbo Feng, Yuntao Wu
A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity through hijacking chemokine coreceptor signaling which activates a host dependency factor cofilin and its kinase, the LIM domain kinase (LIMK). Although knockdown of human LIMK1 with shRNA inhibits HIV infection, no specific small molecule inhibitor of LIMK was available. Here we describe the design and discovery of novel classes of small molecule inhibitors of LIMK for inhibiting HIV infection...
April 5, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28377391/dietary-assessment-of-british-police-force-employees-a-description-of-diet-record-coding-procedures-and-cross-sectional-evaluation-of-dietary-energy-intake-reporting-the-airwave-health-monitoring-study
#7
Rachel Gibson, Rebeca Eriksen, Kathryn Lamb, Yvonne McMeel, Anne-Claire Vergnaud, Jeanette Spear, Maria Aresu, Queenie Chan, Paul Elliott, Gary Frost
OBJECTIVES: Dietary intake is a key aspect of occupational health. To capture the characteristics of dietary behaviour that is affected by occupational environment that may affect disease risk, a collection of prospective multiday dietary records is required. The aims of this paper are to: (1) collect multiday dietary data in the Airwave Health Monitoring Study, (2) describe the dietary coding procedures applied and (3) investigate the plausibility of dietary reporting in this occupational cohort...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28377298/environmental-enrichment-choices-of-shelter-cats
#8
J J Ellis, H Stryhn, J Spears, M S Cockram
Choices made by cats between different types of environmental enrichment may help shelters to prioritize how to most effectively enrich cat housing, especially when limited by space or funds. This study investigates the environmental enrichment use of cats in a choice test. Twenty-six shelter cats were kept singularly in choice chambers for 10 days. Each chamber had a central area and four centrally-linked compartments containing different types of environmental enrichment: 1) an empty control, 2) a prey-simulating toy, 3) a perching opportunity, and 4) a hiding opportunity...
April 1, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28363690/american-urological-association-white-paper-on-the-prevention-and-treatment-of-the-more-common-complications-related-to-prostate-biopsy-update
#9
Michael A Liss, Behfar Ehdaie, Stacy Loeb, Maxwell V Meng, Jay D Raman, Vanessa Spears, Sean P Stroup
OBJECTIVE: To identify the prevalence and prevention of common complications of prostate needle biopsy. MATERIALS AND METHODS: A literature review was performed on prostate biopsy complications. A methodologist queried PubMed and Embase databases for prostate biopsy complications from January 1, 2010 until June 1, 2015. We focus on infection, bleeding, urinary retention, needle tract seeding, and erectile dysfunction. We identified 346 articles for full-text review and selected 119 for inclusion in the final data synthesis...
March 28, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28362683/thrombin-generation-profiles-as-predictors-of-symptomatic-venous-thromboembolism-after-trauma-a-prospective-cohort-study
#10
Myung S Park, Grant M Spears, Kent R Bailey, Ailing Xue, Michael J Ferrara, Amy Headlee, Sabtir K Dhillon, Donald H Jenkins, Scott P Zietlow, William S Harmsen, Aneel A Ashrani, John A Heit
BACKGROUND: Reliable biomarkers predictive of venous thromboembolism (VTE) after acute trauma are uncertain. The objective of the study was to identify risk factors for symptomatic VTE after trauma, including individual plasma coagulome characteristics as reflected by thrombin generation. METHODS: In a prospective, case-cohort study, trauma patients were enrolled over the 4.5 year period, 2011-2015. Blood was collected by venipuncture into 3.2% trisodium citrate at 0, 6, 12, 24 and 72 hours after injury, and at hospital discharge...
March 30, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28344950/impalement-head-injury-with-a-spear
#11
B I Akhiwu, A S Adoga, O P Binitie, C C Ani, M Iweagwu, O Adetutu, T Ureme, D D George, P D Didamson, E Oseni-Momodu, B T Ugwu
Impalement injuries to the craniofacial region are uncommon due to the fact that the face is a smaller target in relation to the rest of the body. We report a case of a 26-year old man who was attacked on the face with a spear. He was promptly evaluated and resuscitated; the blade of the spear was successfully extracted under general anaesthesia. He was discharged home after 2 weeks hospitalization; he has been followed up for three months with good outcome.
April 2016: Journal of the West African College of Surgeons
https://www.readbyqxmd.com/read/28342523/early-experience-with-a-modified-preloaded-system-for-fenestrated-endovascular-aortic-repair
#12
Blandine Maurel, Tim Resch, Rafaelle Spear, Blayne Roeder, Umberto M Bracale, Stephan Haulon, Tara M Mastracci
OBJECTIVE: Preloaded endovascular delivery systems expand the anatomic eligibility for complex aortic repair by requiring only one iliac access vessel and providing a stable platform for guiding sheaths into challenging target vessels. This article reports the lessons learned and early clinical outcomes using a modified preloaded delivery system for fenestrated endovascular aneurysm repair (FEVAR) in three aortic centers in Europe. METHODS: From October 2015 to March 2016, consecutive patients presenting with extensive aortic aneurysm treated with a modified preloaded FEVAR were prospectively enrolled from three high volume European aortic centers...
April 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28342271/more-bark-than-bite-comparative-studies-are-needed-to-determine-the-importance-of-canine-zoonoses-in-aboriginal-communities-a-critical-review-of-published-research
#13
REVIEW
F Smout, L Schrieber, R Speare, L F Skerratt
The objective of this review was to identify and critique over forty years of peer-reviewed literature concerned with the transmission of canine zoonoses to Aboriginal people and determine the zoonotic organisms documented in dogs in Australian Aboriginal communities. A systematic literature search of public health, medical and veterinary databases identified 19 articles suitable for critical appraisal. Thirteen articles documented the occurrence of recognized zoonotic organisms in dogs in Aboriginal communities, including Toxocara canis, Dirofilaria immitis, Streptococcus dysgalactiae, Rickettsia felis, Sarcoptes scabiei and Giardia...
March 25, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28338519/incidence-of-sinusitis-in-burn-victims-and-association-with-inhalational-injury
#14
Nicole M Melchior, Eric M Melchior, Linwood R Haith
The purpose of this study is to determine the incidence of sinusitis in mechanically ventilated burn victims and to examine if the presence of inhalational injury increases the likelihood of developing sinusitis. The authors hypothesize that the incidence of sinusitis will be increased in burn victims who have concomitant inhalational injury. A retrospective chart analysis was performed on all patients who were admitted to the Nathan Speare Regional Burn Treatment Center over a 24-month time frame. Patients who were mechanically ventilated for greater than 24 hours were then selected, resulting in a total of 137 patients for analysis...
March 22, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28331084/structural-insights-into-emerging-pediatric-pathogens-human-bocaparvoviruses
#15
Mario Mietzsch, Shweta Kailasan, Jamie Garrison, Maria Ilyas, Paul Chipman, Kalle Kantola, Mandy E Janssen, John Spear, Duncan Sousa, Robert McKenna, Kevin Brown, Maria Söderlund-Venermo, Timothy Baker, Mavis Agbandje-McKenna
Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocaviruses 1 (HBoV1) causes severe respiratory infections and HBoV2-4 gastrointestinal infections in young children. Recent reports of life threatening cases, lack of direct treatment or vaccination, and a limited understanding of their disease mechanisms demand the need to study these pathogens on a molecular and structural level for the development of therapeutics. Towards this end, the capsid structures of HBoV1, HBoV3, and HBoV4 were determined to 2...
March 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28300506/adding-celecoxib-with-or-without-zoledronic-acid-for-hormone-na%C3%A3-ve-prostate-cancer-long-term-survival-results-from-an-adaptive-multiarm-multistage-platform-randomized-controlled-trial
#16
Malcolm D Mason, Noel W Clarke, Nicholas D James, David P Dearnaley, Melissa R Spears, Alastair W S Ritchie, Gerhardt Attard, William Cross, Rob J Jones, Christopher C Parker, J Martin Russell, George N Thalmann, Francesca Schiavone, Estelle Cassoly, David Matheson, Robin Millman, Cyrill A Rentsch, Jim Barber, Clare Gilson, Azman Ibrahim, John Logue, Anna Lydon, Ashok D Nikapota, Joe M O'Sullivan, Emilio Porfiri, Andrew Protheroe, Narayanan Nair Srihari, David Tsang, John Wagstaff, Jan Wallace, Catherine Walmsley, Mahesh K B Parmar, Matthew R Sydes
Purpose Systemic Therapy for Advanced or Metastatic Prostate Cancer: Evaluation of Drug Efficacy is a randomized controlled trial using a multiarm, multistage, platform design. It recruits men with high-risk, locally advanced or metastatic prostate cancer who were initiating long-term hormone therapy. We report survival data for two celecoxib (Cel)-containing comparisons, which stopped accrual early at interim analysis on the basis of failure-free survival. Patients and Methods Standard of care (SOC) was hormone therapy continuously (metastatic) or for ≥ 2 years (nonmetastatic); prostate (± pelvic node) radiotherapy was encouraged for men without metastases...
March 13, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28288983/a-complication-of-adrenaline-autoinjectors
#17
David Tuthill, Narayana Reddy Vayyeti, Elizabeth Spear, Rebecca Clargo
No abstract text is available yet for this article.
March 13, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28264272/-i-persianorchestia-i-a-new-talitrid-genus-crustacea-amphipoda-talitridae-from-gulf-of-oman-iran
#18
Farzaneh Momtazi, Jim Lowry, Maryam Hekmatara
A new genus and species, Persianorchestia nirvana gen. et sp. nov., is described from the south coast of Iran along the Gulf of Oman. The new genus is characterized by large eyes, gnathopod 1 posterior margin of carpus and propodus each with lobe covered in palmate setae, smooth posterior margin on dactylus of male gnathopod 2, a slender dactylus on pereopod 5, uropod 1 outer ramus without marginal robust setae and with apical spear-shaped setae on the rami of uropods 1 and 2. Persianorchestia is most similar to Pseudorchestoidea Bousfield, 1982...
March 2, 2017: Zootaxa
https://www.readbyqxmd.com/read/28258223/zinc-fingers-and-homeoboxes-2-zhx2-regulates-major-urinary-protein-gene-expression-in-the-mouse-liver
#19
Jieyun Jiang, Kate Townsend Creasy, Justin Purnell, Martha L Peterson, Brett T Spear
The mouse Major Urinary Proteins (Mups) are encoded by a large family of highly related genes clustered on Chromosome 4. Mups, synthesized primarily and abundantly in the liver and secreted through the kidneys, exhibit male-biased expression. Mups bind a variety of volatile ligands; these ligands, and Mup proteins themselves, influence numerous behavioral traits. While urinary Mup protein levels vary between inbred mouse strains, this difference is most pronounced in BALB/cJ mice, which have dramatically low urinary Mup levels; this BALB/cJ trait had been mapped to a locus on chromosome 15...
March 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28244964/real-time-pressure-assessment-and-monitoring-with-a-fluid-immersion-simulation-support-surface-show-clinical-and-financial-benefits-for-flap-management
#20
Marcia Spear, Kristen Thurman
No abstract text is available yet for this article.
January 2017: Plastic Surgical Nursing
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