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https://www.readbyqxmd.com/read/28437753/p-gp-modulatory-acetyl-11-keto-%C3%AE-boswellic-acid-based-nanoemulsified-carrier-system-for-augmented-oral-chemotherapy-of-docetaxel
#1
Gitu Pandey, Naresh Mittapelly, Guru Raghavendra Valicherla, Ravi Prakash Shukla, Shweta Sharma, Venkatesh Teja Banala, Sandeep Urandur, Arun Kumar Jajoriya, Kalyan Mitra, D P Mishra, J R Gayen, P R Mishra
In spite of being a very potent and promising drug against many types of cancer, docetaxel suffers the disadvantage of low solubility and poor bioavailability rendering it unsuitable for oral administration. Also, the available marketed formulation for intravenous administration has its inherent drawbacks owing to the presence of polysorbate 80. Here, we exploited the anticancer and P-gp inhibitory potential of naturally occurring frankincense oil to fabricate a stable docetaxel loaded nanoemulsified carrier system for oral delivery...
April 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28436122/metabolic-engineering-of-escherichia-coli-for-production-of-2-phenylethylacetate-from-l-phenylalanine
#2
Daoyi Guo, Lihua Zhang, Hong Pan, Xun Li
In order to meet the need of consumer preferences for natural flavor compounds, microbial synthesis method has become a very attractive alternative to the chemical production. The 2-phenylethanol (2-PE) and its ester 2-phenylethylacetate (2-PEAc) are two extremely important flavor compounds with a rose-like odor. In recent years, Escherichia coli and yeast have been metabolically engineered to produce 2-PE. However, a metabolic engineering approach for 2-PEAc production is rare. Here, we designed and expressed a 2-PEAc biosynthetic pathway in E...
April 24, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28435731/crystal-structure-and-absolute-configuration-of-4s-5r-6s-4-5-6-trihy-droxy-3-methyl-cyclo-hex-2-enone-gabosine-h
#3
Gaurao D Tibhe, Mario A Macías, Enrique Pandolfi, Valeria Schapiro, Leopoldo Suescun
The mol-ecule of the title keto carbasugar, C7H10O4, is formed by a cyclo-hexene skeleton with an envelope conformation, substituted by carbonyl, methyl and hydroxyl groups. The crystal structure is controlled mainly by a combination of strong O-H⋯O and weak C-H⋯O hydrogen bonds, forming nearly perpendicular chains running parallel to the [110] and [-110] directions. This perpendicularity is caused by a tetra-gonal pseudosymmetry influenced by the similarity between the a and b axes, the value of 90.9770 (10)° of the β angle and the action of a 21 screw axis, which transform each chain into its corresponding nearly orthogonal one...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28431962/structural-basis-chemical-driving-forces-and-biological-implications-of-flavones-as-cu-ii-ionophores
#4
Fang Dai, Wen-Jing Yan, Yu-Ting Du, Xia-Zhen Bao, Xiu-Zhuang Li, Bo Zhou
A main biochemical property of cancer cells, compared with normal cells, is altered redox status including increased levels of copper to maintain their malignant phenotypes. Thus, increasing copper accumulation, by using ionophores, to disrupt abnormal redox homeostasis of cancer cells may be an important anticancer strategy. Naturally occurring molecules with extraordinarily diverse chemical scaffolds are an important source of inspiration for developing copper ionophores. Dietary flavonoids are well-characterized copper chelators and show cancer chemopreventive potential, but their ionophoric role for redox-active copper and the related biological implications have remained unknown...
April 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28431863/the-myometrial-contractility-during-late-pregnancy-in-dairy-cows-in-vitro
#5
L Górriz-Martín, S E Ulbrich, M Schmicke, G Hirsbrunner, C Keller, N Yücesoy, C Pfarrer, H Bollwein, M Heppelmann
This study aimed to investigate the in vitro contractility of the myometrium and its relationship to the blood concentrations of estradiol-17β (E2β), progesterone (P4), 15-keto-13,14-dihydro-PGF2α (PGFM) and ionised calcium (Ca(2+)) prior to tissue harvest in 12 healthy Holstein-Friesian cows in late pregnancy. Three circular (CM) and 3 longitudinal myometrial (LM) strips were dissected during a caesarean section and mounted in an organ bath containing modified Krebs solution (KS). The spontaneous contractility was recorded during five 30-min time periods (T1 to T5), after which the strips were exposed to increasing concentrations of oxytocin (OT; 10(-10)-10(-7)M), a natural PGF2α-analogue (PGF; 10(-7)-10(-4)M) and KS (Cont) for four 30-min time periods (T6 to T9)...
April 7, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28429299/participation-of-c-h-protons-in-the-dissociation-of-a-proton-deficient-dipeptide
#6
Damodar Koirala, Sabyasachy Mistry, Paul G Wenthold
The dissociation of anionic dipeptides Phe*Gly and GlyPhe*, where Phe* refers to sulfonated phenyl alanine, has been investigated by using ion trap mass spectrometry. The dipeptides undergo collision-induced dissociation (CID) to give the same products, indicating that they rearrange to a common structure before dissociation. The rearrangement does not occur with the dipeptide methyl esters. The structures of the b2 ions were investigated to determine the effect that having a remote, anionic site has on product formation...
April 20, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28425958/reactions-of-5-indolizyl-lithium-compounds-with-some-bielectrophiles
#7
Sergey A Rzhevskii, Victor B Rybakov, Victor N Khrustalev, Eugene V Babaev
Abstract: Indolizyl-5-lithium anions react with succinic and phtalic anhidrides giving 1,4-keto acids, with oxallyl chloride giving 1,2-diketone, and with ethyl pyruvate giving 1,2-hydroxyacid. However, with α-halocarbonyl compounds, they react in different ways, forming the products of selective bromination at C-5 (with α-bromo ketones and esters of α-bromo acids) and 5-chloroacetyl indolizines.
April 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28423012/15-hydroxyprostaglandin-dehydrogenase-15-pgdh-prevents-lipopolysaccharide-lps-induced-acute-liver-injury
#8
Lu Yao, Weina Chen, Kyoungsub Song, Chang Han, Chandrashekhar R Gandhi, Kyu Lim, Tong Wu
The NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the pro-inflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ligand for peroxisome proliferator-activated receptor-gamma [PPAR-γ]). To evaluate the significance of 15-PGDH/15-keto-PGE2 cascade in liver inflammation and tissue injury, we generated transgenic mice with targeted expression of 15-PGDH in the liver (15-PGDH Tg) and the animals were subjected to lipopolysaccharide (LPS)/Galactosamine (GalN)-induced acute liver inflammation and injury...
2017: PloS One
https://www.readbyqxmd.com/read/28422067/synthesis-characterization-antimicrobial-and-antiproliferative-activity-evaluation-of-cu-ii-co-ii-zn-ii-ni-ii-and-pt-ii-complexes-with-isoniazid-derived-compound
#9
Elena Pahonțu, Diana-Carolina Ilieș, Sergiu Shova, Camelia Oprean, Virgil Păunescu, Octavian Tudorel Olaru, Flavian Ștefan Rădulescu, Aurelian Gulea, Tudor Roșu, Doina Drăgănescu
Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N'-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as IR (infrared), ¹H-NMR and (13)C-NMR (hydrogen and carbon nuclear magnetic resonance, UV-Vis (ultraviolet-visible), FAB (fast atom bombardment), EPR (electron paramagnetic resonance), and mass spectroscopies...
April 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28420869/verification-of-oligomycin-a-structure-synthesis-and-biological-evaluation-of-33-dehydrooligomycin-a
#10
Lyudmila N Lysenkova, Oleg Y Saveljev, Natalya E Grammatikova, Vladimir B Tsvetkov, Olga B Bekker, Valery N Danilenko, Lyubov G Dezhenkova, Eugene E Bykov, Olga A Omelchuk, Alexander M Korolev, Andrey E Shchekotikhin
Although, the structure of oligomycin A (1) was confirmed by spectroscopic and chemical evaluations, some crystallographic data cast doubt on the originally adopted structure of the side 2-hydroxypropyl moiety of this antibiotic. It was suggested that the side chain of the oligomycin is enol-related (2-hydroxy-1-propenyl). To clarify this matter we synthesized and evaluated 33-dehydrooligomycin A (2) prepared by the Kornblum oxidation of 33-O-mesyloligomycin A (3) by dimethyl sulfoxide. NMR data for 33-dehydrooligomycin (2) and results of quantum chemical calculations have shown that this derivative exists in the keto rather than in the enol tautomer 2a...
April 19, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28420137/modification-of-the-mycotoxin-deoxynivalenol-using-microorganisms-isolated-from-environmental-samples
#11
Nina M Wilson, Nicole McMaster, Dash Gantulga, Cara Soyars, Susan P McCormick, Ken Knott, Ryan S Senger, David G Schmale
The trichothecene mycotoxin deoxynivalenol (DON) is a common contaminant of wheat, barley, and maize. New strategies are needed to reduce or eliminate DON in feed and food products. Microorganisms from plant and soil samples collected in Blacksburg, VA, USA, were screened by incubation in a mineral salt media containing 100 μg/mL DON and analysis by gas chromatography mass spectrometry (GC/MS). Two mixed cultures derived from soil samples consistently decreased DON levels in assays using DON as the sole carbon source...
April 15, 2017: Toxins
https://www.readbyqxmd.com/read/28417362/analyzing-activities-of-lytic-polysaccharide-monooxygenases-by-liquid-chromatography-and-mass-spectrometry
#12
Bjørge Westereng, Magnus Ø Arntzen, Jane Wittrup Agger, Gustav Vaaje-Kolstad, Vincent G H Eijsink
Lytic polysaccharide monooxygenases perform oxidative cleavage of glycosidic bonds in various polysaccharides. The majority of LMPOs studied so far possess activity on either cellulose or chitin and analysis of these activities is therefore the main focus of this review. Notably, however, the number of LPMOs that are active on other polysaccharides is increasing. The products generated by LPMOs from cellulose are either oxidized in the downstream end (at C1) or upstream end (at C4), or at both ends. These modifications only result in small structural changes, which makes both chromatographic separation and product identification by mass spectrometry challenging...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28417264/branched-chain-amino-acids-and-brain-metabolism
#13
Justin E Sperringer, Adele Addington, Susan M Hutson
This review aims to provide a historical reference of branched-chain amino acid (BCAA) metabolism and provide a link between peripheral and central nervous system (CNS) metabolism of BCAAs. Leucine, isoleucine, and valine (Leu, Ile, and Val) are unlike most other essential amino acids (AA), being transaminated initially in extrahepatic tissues, and requiring interorgan or intertissue shuttling for complete catabolism. Within the periphery, BCAAs are essential AAs and are required for protein synthesis, and are key nitrogen donors in the form of Glu, Gln, and Ala...
April 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28411798/polyelectrolyte-mediated-nano-hybrid-particle-as-a-nano-sensor-with-outstandingly-amplified-specificity-and-sensitivity-for-enzyme-free-estimation-of-cholesterol
#14
Mazhar Chebl, Zeinab Moussa, Markus Peurla, Digambara Patra
As a proof of concept, here it is established that curcumin integrated chitosan oligosaccharide lactate (COL) self-assembles on silica nanoparticle surface to form nano hybrid particles (NHPs). These NHPs have size in the ranges of 25-35nm with silica nanoparticle as its core and curcumin-COL as outer layer having thickness of 4-8nm. The fluorescence intensity of these NHPs are found to be quenched and emission maximum is ~50nm red shifted compared to free curcumin implying inner filter effect and/or homo-FRET between curcumin molecules present on the surface of individual nano hybrid particle...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28411126/low-interleukin-2-concentration-favors-generation-of-early-memory-t-cells-over-effector-phenotypes-during-chimeric-antigen-receptor-t-cell-expansion
#15
Tanja Kaartinen, Annu Luostarinen, Pilvi Maliniemi, Joni Keto, Mikko Arvas, Heini Belt, Jonna Koponen, Angelica Loskog, Satu Mustjoki, Kimmo Porkka, Seppo Ylä-Herttuala, Matti Korhonen
BACKGROUND: Adoptive T-cell therapy offers new options for cancer treatment. Clinical results suggest that T-cell persistence, depending on T-cell memory, improves efficacy. The use of interleukin (IL)-2 for in vitro T-cell expansion is not straightforward because it drives effector T-cell differentiation but does not promote the formation of T-cell memory. We have developed a cost-effective expansion protocol for chimeric antigen receptor (CAR) T cells with an early memory phenotype...
April 11, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28409934/diastereoselective-synthesis-of-cephalotaxus-esters-via-asymmetric-mukaiyama-aldol-reaction
#16
Guo-Zhen Ma, Peng-Fei Li, Lu Liu, Wei-Dong Z Li, Li Chen
We report a protocol for efficient stereoselective installation of the chiral oxygen-containing tetrasubstituted tertiary carbon stereocenter of the side chain of cephalotaxus esters by means of highly diastereoselective Mukaiyama aldol reactions between α-keto esters (2) and a (Z)-α-chloro ketene silyl acetal. This protocol permitted synthesis of cephalotaxus esters including six natural products in good to excellent yields (up to 94%) with high diastereoselectivities (dr up to 97:3) and could be performed on a multigram scale...
April 14, 2017: Organic Letters
https://www.readbyqxmd.com/read/28409435/aldo-ketoreductase-1-akr1-improves-seed-longevity-in-tobacco-and-rice-by-detoxifying-reactive-cytotoxic-compounds-generated-during-ageing
#17
Nisarga Kodadinne Narayana, Ramu S Vemanna, Babitha Kodekallu Chandrashekar, Hanumantha Rao, Amaranatha Reddy Vennapusa, Ashwini Narasimaha, Udayakumar Makarla, Mohan Raju Basavaiah
BACKGROUND: Maintenance of seed viability is an important factor for seedling vigour and plant establishment. Lipid peroxidation mediated reactive carbonyl compounds (RCC's) and non-enzymatic modifications of proteins through Maillard and Amadori products reduce seed viability and seedling vigour. RESULTS: In this study, the relevance of RCCs on genotypic variation in rice seed viability and overexpression of an aldo-ketoreductase (AKR1) enzyme that detoxify cytotoxic compounds to improve seed viability and vigour was studied...
December 2017: Rice
https://www.readbyqxmd.com/read/28409336/dietary-docosahexaenoic-acid-and-trans-10-cis-12-conjugated-linoleic-acid-differentially-alter-oxylipin-profiles-in-mouse-periuterine-adipose-tissue
#18
Yuriko Adkins, Benjamin J Belda, Theresa L Pedersen, Dawn M Fedor, Bruce E Mackey, John W Newman, Darshan S Kelley
Diets containing high n-3 polyunsaturated fatty acids (PUFA) decrease inflammation and the incidence of chronic diseases including cardiovascular disease and nonalcoholic fatty liver disease while trans-fatty acids (TFA) intake increases the incidence of these conditions. Some health benefits of n-3 PUFA are mediated through the impact of their oxygenated metabolites, i.e. oxylipins. The TFA, trans-10, cis-12-conjugated linoleic acid (CLA; 18:2n-6) is associated with adipose tissue (AT) inflammation, oxidative stress, and wasting...
April 13, 2017: Lipids
https://www.readbyqxmd.com/read/28406521/dissection-of-the-neocarazostatin-a-c4-alkyl-side-chain-biosynthesis-by-in-vitro-reconstitution
#19
Li Su, Rui Zhang, Kwaku Kyeremeh, Zixin Deng, Hai Deng, Yi Yu
Neocarazostatin A (1) is a potent free radical scavenger possessing an intriguing tricyclic carbazole nucleus with a C4 alkyl side chain attached to ring "A". Although the biosynthetic gene cluster of 1 (nzs) has been identified, and several key steps of the pathway have been well characterized, the enzyme(s) involved in the biosynthesis of the C4 unit still remains obscure. In this work, we demonstrate that three enzymes, including one (MA37-FabG) from primary fatty acid metabolism and two pathway-specific ones (NzsE and NzsF), are responsible for the formation of the side chain precursor...
April 13, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28406311/organocatalytic-asymmetric-decarboxylative-amination-of-%C3%AE-keto-acids-access-to-optically-active-%C3%AE-amino-ketones-and-1-2-amino-alcohols
#20
Yi Wei, Heng-Xia Zhang, Jun-Liang Zeng, Jing Nie, Jun-An Ma
An organocatalytic asymmetric decarboxylative amination reaction of β-keto acids is described. Under mild reaction conditions, a series of chiral α-amino ketones were obtained in good to high yields (up to 99%) and enantioselectivities (up to 95% ee). A chiral 1,2-amino alcohol was synthesized from the corresponding decarboxylative amination product in several steps without loss of enantioselectivity.
April 13, 2017: Organic Letters
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