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https://www.readbyqxmd.com/read/29150511/sulfolobus-acidocaldarius-uptakes-pentoses-via-a-cut2-type-abc-transporter-and-metabolizes-them-through-the-aldolase-independent-weimberg-pathway
#1
Michaela Wagner, Lu Shen, Andreas Albersmeier, Nienke van der Kolk, Sujin Kim, Jaeho Cha, Christopher Bräsen, Jörn Kalinowski, Bettina Siebers, Sonja-Verena Albers
Sulfolobus spp. possess a great metabolic versatility and grow heterotrophically on various carbon sources such as different sugars and peptides. Known sugar transporters in Archaea predominantly belong to ABC transport systems. Although several ABC transporters for sugar uptake have been characterized in the crenarchaeon Sulfolobus solfataricus, only one homologue of these transporters, the maltose/maltooligomer transporter, could be identified in the closely related Sulfolobus acidocaldarius Comparison of the transcriptome of S...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29149663/%C3%AE-keto-tetrahydrofuran-lignan-glucosides-from-the-bangladeshi-medicinal-plant-terminalia-citrina-inhibit-estradiol-e2-induced-proliferation-in-cancer-cells
#2
Md Abdul Muhit, Kaoru Umehara, Hiroshi Noguchi
EtOAc extract from the leaves of Terminalia citrina collected in Bangladesh were separated, and seven previously undescribed α-keto tetrahydrofuran lignan glucosides (terminalosides Q to W) were isolated and characterized. NOESY analysis of (1)H NMR spectra and ECD spectroscopic data analysis revealed the absolute stereochemistry of the tetrahydrofuran ring of the isolated constituents as being a (7S,8R,8'S)- configuration in terminalosides Q to U and a (7R,8R,8'S)- configuration in terminalosides V and W...
November 14, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29148746/keto-enol-tautomerization-triggers-an-electrophilic-aldehyde-deformylation-reaction-by-a-nonheme-manganese-iii-peroxo-complex
#3
Fabián G Cantú Reinhard, Prasenjit Barman, Gourab Mukherjee, Jitendra Kumar, Deep Kumar, Devesh Kumar, Chivukula V Sastri, Sam P de Visser
Oxygen atom transfer by high-valent enzymatic intermediates remains an enigma in chemical catalysis. In particular, manganese is an important first-row metal involved in key biochemical processes including the biosynthesis of mo-lecular oxygen (through the photosystem II complex) and biodegradation of toxic superoxide to hydrogen peroxide by superoxide dismutase. Biomimetic models of these biological systems have been developed to gain understanding on the structure and properties of short-lived intermediates but also with the aim to create environmentally benign oxidants...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29148251/the-enzymatic-detoxification-of-the-mycotoxin-deoxynivalenol-identification-of-depa-from-the-don-epimerization-pathway
#4
Jason Carere, Yousef I Hassan, Dion Lepp, Ting Zhou
The biological detoxification of mycotoxins, including deoxynivalenol (DON), represents a very promising approach to address the challenging problem of cereal grain contamination. The recent discovery of Devosia mutans 17-2-E-8 (Devosia spp. 17-2-E-8), a bacterial isolate capable of transforming DON to the non-toxic stereoisomer 3-epi-deoxynivalenol, along with earlier reports of bacterial species capable of oxidizing DON to 3-keto-DON, has generated interest in the possible mechanism and enzyme(s) involved...
November 17, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29146531/specific-oxygenation-of-plasma-membrane-phospholipids-by-pseudomonas-aeruginosa-lipoxygenase-induces-structural-and-functional-alterations-in-mammalian-cells
#5
Maceler Aldrovandi, Swathi Banthiya, Sven Meckelmann, You Zhou, Dagmar Heydeck, Valerie B O'Donnell, Hartmut Kuhn
Pseudomonas aeruginosa is a gram-negative pathogen, which causes life-threatening infections in immunocompromized patients. These bacteria express a secreted lipoxygenase (PA-LOX), which oxygenates free arachidonic acid to 15S-hydro(pero)xyeicosatetraenoic acid. It binds phospholipids at its active site and physically interacts with lipid vesicles. When incubated with red blood cells membrane lipids are oxidized and hemolysis is induced but the structures of the oxygenated membrane lipids have not been determined...
November 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29143818/visualization-of-chemical-modifications-in-the-human-80s-ribosome-structure
#6
S Kundhavai Natchiar, Alexander G Myasnikov, Hanna Kratzat, Isabelle Hazemann, Bruno P Klaholz
Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis and have been implicated in the dysregulation of protein synthesis, as is found in cancer and other diseases. However, their role in this phenomenon is unknown. Here we visualize more than 130 individual rRNA modifications in the three-dimensional structure of the human ribosome, explaining their structural and functional roles. In addition to a small number of universally conserved sites, we identify many eukaryote- or human-specific modifications and unique sites that form an extended shell in comparison to bacterial ribosomes, and which stabilize the RNA...
November 15, 2017: Nature
https://www.readbyqxmd.com/read/29143011/iron-catalyzed-peroxidation-carbamoylation-of-alkenes-with-hydroperoxides-and-formamides-via-formyl-c-sp-2-h-functionalization
#7
Jun-Kee Cheng, Liang Shen, Liu-Hai Wu, Xu-Hong Hu, Teck-Peng Loh
A reaction protocol in which FeCl3 and tert-butyl hydroperoxide facilitated a selective radical coupling reaction of aryl alkenes or 1,3-enynes with tert-butyl hydroperoxide and formamides to prepare an array of β-peroxy amides has been achieved. The β-peroxy amide could serve as a synthetic precursor which was facilely converted to β-hydroxy amide, β-keto amide and β-lactam following subsequent chemical transformation.
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29142318/the-natural-product-carolacton-inhibits-folate-dependent-c1-metabolism-by-targeting-fold-mthfd
#8
Chengzhang Fu, Asfandyar Sikandar, Jannik Donner, Nestor Zaburannyi, Jennifer Herrmann, Michael Reck, Irene Wagner-Döbler, Jesko Koehnke, Rolf Müller
The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum, and was originally described as an antibacterial compound. Here we show that carolacton targets FolD, a key enzyme from the folate-dependent C1 metabolism. We characterize the interaction between bacterial FolD and carolacton biophysically, structurally and biochemically. Carolacton binds FolD with nanomolar affinity, and the crystal structure of the FolD-carolacton complex reveals the mode of binding...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29138027/imidazo-1-2-a-pyridines-linked-with-thiazoles-thiophene-motif-through-keto-spacer-as-potential-cytotoxic-agents-and-nf-%C3%AE%C2%BAb-inhibitors
#9
Kamala K Vasu, Chander Singh Digwal, Amit N Pandya, Dhaivat H Pandya, Jayesh A Sharma, Sneha Patel, Milee Agarwal
A series of new imidazo[1,2-a]pyridine linked with thiazole/thiophene motif through a keto spacer were synthesized and tested for their cytotoxic potential against three human cancer cell lines including A549, HeLa and U87-MG using MTT assay. Compounds A2, A3, A4, C1 and C2 showed cytotoxicity against all the three cell lines. The selectivity index for compound A4 for A549 and HeLa cells was comparable to that of doxorubicin. Among the synthesized compounds, B5 showed the maximum inhibition of NF-κB activity as ascertained by NF-κB reporter assay (IC50 = 6...
November 11, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29137357/akr7a3-suppresses-tumorigenicity-and-chemoresistance-in-hepatocellular-carcinoma-through-attenuation-of-erk-c-jun-and-nf-%C3%AE%C2%BAb-signaling-pathways
#10
Raymond Kwok Kei Chow, Sarah Tsz-Kwan Sin, Ming Liu, Yan Li, Tim Hon Man Chan, Yangyang Song, Leilei Chen, Dora Lai-Wan Kwong, Xin-Yuan Guan
Hepatocellular carcinoma (HCC), which accounts for 85-90% of primary liver cancer, is now the second leading cause of cancer-related mortality worldwide. Here we reported that Aldo-Keto Reductase family 7A isoform 3 (AKR7A3) is frequently down-regulated in HCC, associating with poor overall survival rate, elevated serum α-fetoprotein (AFP) and poor differentiation of HCC. The promoter region of AKR7A3 was detected to be hypermethylated. Loss of heterozygosity (LOH) was also detected in AKR7A3. Functional assays on both AKR7A3 overexpressed and knockdown cells, including foci formation, colony formation in soft agar, migration, invasion and tumor formation in nude mice, demonstrated the strong tumor suppressive functions of AKR7A3...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133056/therapeutic-potential-of-songorine-a-diterpenoid-alkaloid-of-the-genus-aconitum
#11
REVIEW
Haroon Khan, Seyed Mohammad Nabavi, Antoni Sureda, Nikolay Mehterov, Diana Gulei, Ioana Berindan-Neagoe, Hiroaki Taniguchi, Atanas G Atanasov
Alkaloids are well-studied secondary metabolites, with recent preclinical studies evidencing that many of them exhibit anti-cancer, anti-depressant, anti-nociceptive, anti-inflammatory, anti-pyretic, anti-platelet, anti-oxidant, and anti-bacterial properties. Aconitum is a genus rich of diverse alkaloids. More than 450 alkaloids have been identified in a variety of species. Songorine is a C20 diterpenoid alkaloid and 12-keto analog of napelline, isolated from Aconitum soongaricum and was associated with a heterogeneous panel of biological functions...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29132038/hemodynamics-of-the-corpus-luteum-in-mares-during-experimentally-impaired-luteogenesis-and-partial-luteolysis
#12
J C Ferreira, L F Novaes Filho, Y L Boakari, H S Canesin, D L Thompson, F S Lima, C Meira
The aim of the current project was to characterize the luteal vascularity and the plasma concentrations of progesterone (P4), prolactin (PRL) and 13,14-dihydro-15-keto-PGF2α (PGFM) in mares with luteal disturbances during early and mid-diestrus. In Experiment 1, twenty-one mares were treated with 2 mL of 0.9% NaCl, or 1 mg Dinoprost, or 10 mg Dinoprost on day two after ovulation (Control-D2, 1/10PGF-D2 and PGF-D2 groups, respectively; n = 7 mares/group). In Experiment 2, similar treatments were performed eight days post-ovulation using a different cohort of 21 mares (Control-D8, 1/10PGF-D8 and PGF-D8 groups, respectively; n = 7 mares/group)...
November 4, 2017: Theriogenology
https://www.readbyqxmd.com/read/29132037/flunixin-meglumine-improves-pregnancy-rate-in-embryo-recipient-beef-cows-with-an-excitable-temperament
#13
R K Kasimanickam, J B Hall, C T Estill, J P Kastelic, C Joseph, R L Abdel Aziz, D Nak
Objectives were to determine effects of: 1) handling temperament and administration of flunixin meglumine, an inhibitor of prostaglandin F2a (PGF2a) synthesis, given at the time of embryo transfer, on pregnancy rates in beef cattle embryo transfer recipients; 2) handling temperament and flunixin meglumine on peripheral concentrations of progesterone, cortisol, substance-P, prostaglandin F metabolites (PGFM, (13,14-dihydro-15-keto-PGF2a) and isoprostane 8-epi PGF2a; and 3) flunixin meglumine treatment on proportion of non-pregnant recipient cows returning to estrus within an expected interval...
November 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/29128619/preparation-of-porous-carbon-spheres-from-2-keto-l-gulonic-acid-mother-liquor-by-oxidation-and-activation-for-electric-double-layer-capacitor-application
#14
Zhi-Qiang Hao, Jing-Pei Cao, Xiao-Yan Zhao, Yan Wu, Jun-Sheng Zhu, Ya-Li Dang, Qi-Qi Zhuang, Xian-Yong Wei
A novel strategy is proposed for the increase of specific surface area (SSA) of porous carbon sphere (PCS) by oxidation and activation. 2-keto-l-gulonic acid mother liquor (GAML) as a high-pollution waste has a relatively high value of reutilization. For its high value-added utilization, GAML is used as the precursor for preparation of PCS as carbon-based electrode materials for electric double-layer capacitor. PCS is prepared by hydrothermal carbonization, carbonization and KOH activation, and Fe(NO3)3 9H2O is used as an oxidizing agent during carbonization...
November 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29122174/differential-gene-expression-profiling-analysis-in-pleurotus-ostreatus-during-interspecific-antagonistic-interactions-with-dichomitus-squalens-and-trametes-versicolor
#15
Zixuan Zhong, Liu Li, Peng Chang, Haiying Xie, Huiting Zhang, Yasuo Igarashi, Nannan Li, Feng Luo
This study provided analysis of differentially expressed genes (DEGs) in Pleurotus ostreatus under the interaction with Dichomitus squalens and Trametes versicolor, which is valuable for exploration on the fungal defence system against stressful condition caused by interspecific antagonistic interaction. Our result showed significant upregulation of abundant defence-related genes encoding laccase, manganese peroxidase, aldo-keto reductase, and glutathione S-transferase, which all play important roles in oxidative stress-resistant response...
December 2017: Fungal Biology
https://www.readbyqxmd.com/read/29117945/adipocytes-sequester-and-metabolize-the-chemotherapeutic-daunorubicin
#16
Xia Sheng, Jean-Hugues Parmentier, Jonathan Tucci, Hua Pei, Omar Cortez-Toledo, Christina M Dieli-Conwright, Matthew J Oberley, Michael Neely, Etan Orgel, Stan G Louie, Steven D Mittelman
Obesity is associated with poorer outcome for many cancers. Previously, we observed that adipocytes protect acute lymphoblastic leukemia (ALL) cells from the anthracycline, daunorubicin. In this study, it is determined whether adipocytes clear daunorubicin from the tumor microenvironment (TME). Intracellular daunorubicin concentrations were evaluated using fluorescence. Daunorubicin and its largely inactive metabolite, daunorubicinol, were analytically measured in media, cells, and tissues using liquid chromatography/mass spectrometry (LC/MS)...
November 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29112340/finnish-dentists-find-smoking-cessation-important-but-seldom-offer-practical-support-for-their-patients
#17
A Grönholm, D Litkey, J Jokelainen, J Keto, M Pöyry, K Linden, A M Heikkinen
OBJECTIVES: To investigate Finnish dentists' smoking cessation related attitudes, consultation practices and familiarity with the local treatment guideline on smoking cessation. BASIC RESEARCH DESIGN: An online questionnaire was sent to 1740 dentists, which corresponds to 39% of dentists in Finland. A total of 456 dentists responded (response rate 26%), of whom 435 (95%) were clinicians. The dentists' smoking cessation practices were also compared to ones reported in a previous study in Finnish physicians...
November 10, 2017: Community Dental Health
https://www.readbyqxmd.com/read/29111689/functional-characterization-of-a-condensation-domain-that-links-nonribosomal-peptide-and-pteridine-biosynthetic-machineries-in-photorhabdus-luminescens
#18
Corey E Perez, Hyun Bong Park, Jason M Crawford
Nonribosomal peptide synthetases (NRPSs) produce a wide variety of biologically important small molecules. NRPSs can interface with other enzymes to form hybrid biosynthetic systems that expand the structural and functional diversity of their products. The pepteridines are metabolites encoded by an unprecedented pteridine-NRPS-type hybrid biosynthetic gene cluster in Photorhabdus luminescens, but how the distinct enzymatic systems interface to produce these molecules has not been examined at the biochemical level...
November 7, 2017: Biochemistry
https://www.readbyqxmd.com/read/29110642/in-vivo-functional-analysis-of-l-rhamnose-metabolic-pathway-in-aspergillus-niger-a-tool-to-identify-the-potential-inducer-of-rhar
#19
Claire Khosravi, Roland Sándor Kun, Jaap Visser, María Victoria Aguilar-Pontes, Ronald P de Vries, Evy Battaglia
BACKGROUND: The genes of the non-phosphorylative L-rhamnose catabolic pathway have been identified for several yeast species. In Schefferomyces stipitis, all L-rhamnose pathway genes are organized in a cluster, which is conserved in Aspergillus niger, except for the lra-4 ortholog (lraD). The A. niger cluster also contains the gene encoding the L-rhamnose responsive transcription factor (RhaR) that has been shown to control the expression of genes involved in L-rhamnose release and catabolism...
November 6, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29110592/recent-developments-on-phenstatins-as-potent-antimitotic-agents
#20
Xing Chen, Shi-Meng Wang, Gajjela Bharath Kumar, Grant A L Bare, Jing Leng, Syed Nasir Abbas Bukhari, Hua-Li Qin
Phenstatin and their derivatives display remarkable antiproliferative activity toward a wide variety of preclinical tumor models. Phenstatins inhibit tubulin polymerization through their interaction at the colchicine binding site of microtubules and arrest the G2/M phase of the cell cycle. Moreover, the structural simplicity and excellent stability of phenstatins offer a stimulating premise for developing various derivatives with profound antimitotic activity and excellent cytotoxicity. In addition, phenstatin derivatives are undergoing clinical evaluation as vascular targeting/disrupting agents and also exhibit direct antiangiogenic properties...
November 6, 2017: Current Medicinal Chemistry
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