Trinity J Bivalacqua, Weiwen Deng, Muammer Kendirci, Mustafa F Usta, Christine Robinson, Bradley K Taylor, Subramanyam N Murthy, Hunter C Champion, Wayne J G Hellstrom, Philip J Kadowitz
Mesenchymal stem cells (MSCs) can be used in adult stem cell-based gene therapy for vascular diseases. To test the hypothesis that MSCs alone or endothelial nitric oxide synthase (eNOS)-modified MSCs can be used for treatment of erectile dysfunction (ED), syngeneic rat MSCs (rMSCs) were isolated, ex vivo expanded, transduced with adenovirus containing eNOS, and injected into the penis of aged rats. Histological analysis demonstrated that rMSCs survived for at least 21 days in corporal tissue after intracavernous injection, and an inflammatory response was not induced...
March 2007: American Journal of Physiology. Heart and Circulatory Physiology