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Kinga Mikrut, Justyna Kupsz, Jacek Kozlik, Hanna Krauss, Ewa Pruszynska-Oszmałek, Magdalena Gibas-Dorna
AIM: To investigate whether endogenous bradykinin is involved in the antioxidant action of angiotensin-converting enzyme inhibitors (ACEIs) in acute hyperglycemia. METHODS: Male Wistar rats were divided into the normoglycemic group (n=40) and the hyperglycemic group (n=40). Hyperglycemia was induced by a single intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight) dissolved in 0.1 mol/L citrate buffer (pH 4.5) 72 hours before sacrifice. The normoglycemic group received the same volume of citrate buffer...
August 31, 2016: Croatian Medical Journal
Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino
Increasing evidence witnesses that cancer metabolism alterations represent a critical hallmark for many types of human tumors. There is a strong need to understand and dissect the molecular mechanisms underlying cancer metabolism to envisage specific biomarkers and underpin critical molecular components that might represent novel therapeutic targets. One challenge, that is the focus of this review, is the reprogramming of the altered metabolism of a cancer cell toward that of un-transformed cell. The anti-hyperglicemic agent, metformin has proven to be effective in reprogramming the metabolism of cancer cells even from those subpopulations endowed with cancer stem like features and very high chemoresistenace to conventional anticancer treatments...
June 2014: Annals of Translational Medicine
Sergio D Gadau
OBJECTIVES: Schwann cells may be involved in the pathogenesis of several neuropathies, such as those linked to an excess of d-glucose. Indeed, hyperglicemic condition can often result in the production of high reactive/nitrosative oxygen species concentration and possible damage of several cell structures. In the present work attention has been focused on the possible nitrosative effect of hyperglycemia on RT4 Schwannoma cell lines. METHODS: Cells were cultured for 72hrs in the presence of 180 mM D-glucose...
2012: Neuro Endocrinology Letters
G Quiroz, R Femat
Compartmental-Physiological Models (CPM's) have been used to derive feedback controllers for the glucose regulation in Diabetes Mellitus (DM). Despite these important advances, there are two criticisms about the use of the CPM's in DM: (i) Can this class of model reproduce severe basal glucose levels (e.g., larger than 300 mg/dl)? and (ii) Does a CPM reproduce a distinct glucose level as its parameters change or is it unique even if its parameters change? This contribution aims these criticisms from the study of the parametric sensitivity of a CPM...
December 2007: Mathematical Biosciences
E Milla
The extrusion mechanism of d-glucose by tubular cells was investigated in isolated rabbit kidneys perfused with normal or hyperglicemic blood, added with 14C-inulin, by relating the values of the ratio between the intracellular and extracellular glucose concentration (Gi/Ge) in the cortical tissue to the respective plasma concentration Gp (= Ge). The apparent extracellular space was calculated in each experiment from the kinetics of the 14C-inulin efflux from cortical slices excised at the end of the perfusion period (mean value = 20...
October 1980: Pflügers Archiv: European Journal of Physiology
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