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Gastroesophageal reflux respiratory disease

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https://www.readbyqxmd.com/read/29449669/predictive-biomarkers-of-gastroesophageal-reflux-disease-and-barrett-s-esophagus-in-world-trade-center-exposed-firefighters-a-15-year-longitudinal-study
#1
Syed H Haider, Sophia Kwon, Rachel Lam, Audrey K Lee, Erin J Caraher, George Crowley, Liqun Zhang, Theresa M Schwartz, Rachel Zeig-Owens, Mengling Liu, David J Prezant, Anna Nolan
Gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked to obstructive airways disease (OAD). We aim to identify serum biomarkers of GERD/BE, and assess the respiratory and clinical phenotype of a longitudinal cohort of never-smoking, male, WTC-exposed rescue workers presenting with pulmonary symptoms. Biomarkers collected soon after WTC-exposure were evaluated in optimized predictive models of GERD/BE...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29438655/short-term-neurodevelopmental-outcome-in-children-born-with-high-risk-congenital-lung-lesions
#2
Enrico Danzer, Casey Hoffman, Jo Ann D'Agostino, Matthew M Boelig, Marsha Gerdes, Judy C Bernbaum, Hannah Rosenthal, Lindsay N Waqar, Natalie E Rintoul, Lisa M Herkert, Michael J Kallan, William H Peranteau, Alan W Flake, N Scott Adzick, Holly L Hedrick
BACKGROUND: To evaluate neurodevelopmental outcome in high-risk congenital lung lesions (CLLs) survivors who underwent prenatal intervention or postnatal surgery within the first month of life. METHODS: Forty-five high-risk CLLs survivors underwent assessment using the Bayley Scales of Infant Development, 3rd Edition between 07/2004 and 12/2016. Scores were grouped as average, at-risk, and delayed based on standard deviation intervals. Correlations between outcome and risk factors were analyzed by Fisher's exact test or two-sided t-test as appropriate, with significant p-values <0...
February 10, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29436209/focus-on-gastroesophageal-reflux-ger-and-laryngopharyngeal-reflux-lpr-new-pragmatic-insights-in-clinical-practice
#3
M Gelardi, G Ciprandi
Gastroesophageal reflux (GER) is a common disease usually limited to the oesophagus. Laryngopharyngeal reflux (LPR) is an inflammatory reaction of the mucosa of pharynx, larynx, and other associated upper respiratory organs, caused by a reflux of stomach contents outside the oesophagus. LPR is considered to be a relatively new clinical entity with a vast number of clinical manifestations which are treated sometimes empirically and without a correct diagnosis. However, there is disagreement between specialists about its definition and management: gastroenterologists consider LPR to be a substantially rare manifestation of gastroesophageal reflux disease (GERD), whereas otolaryngologists believe that LPR is an independent, but common in their practice, disorder...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29430111/scintigraphic-evaluation-of-esophageal-motility-and-gastroesophageal-reflux-in-patients-presenting-with-upper-respiratory-tract-symptoms
#4
Jaykanth Amalachandran, Shelley Simon, Indirani Elangoven, Avani Jain, Thangalakshmi Sivathapandi
Purpose of Study: The purpose is to evaluate the findings and utility of esophageal transit scintigraphy (ETS) and gastroesophageal reflux scintigraphy (GES) in patients presenting with upper respiratory tract (URT) symptoms suspected to be due to gastroesophageal reflux (GER) disease. Materials and Methods: Thirty patients aged between 19 and 60 years underwent nasopharyngolaryngoscopy (NPL), ETS, and GES. Correlation between GER, esophageal motility, and NPL was evaluated...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29413212/gastroesophageal-reflux-regurgitation-in-the-infant-population
#5
REVIEW
Teresa D Ferguson
Gastroesophageal reflux (GER) is common in infancy and mainly treated through nonpharmacological interventions. Knowing the early warning signs of GER is important for nursing assessment. Untreated GER can become acute when an infant fails to gain weight and has recurrent, forceful vomiting. Further investigation of gastroesophageal reflux disease (GERD) is indicated when failure to gain weight, irritability, swallowing difficulties, regurgitation, and respiratory complications occur and should trigger referral to pediatric specialists...
March 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29403270/low-back-pain-and-gastroesophageal-reflux-in-patients-with-copd-the-disease-in-the-breath
#6
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice Sacconi, Philippe Caiazzo, Roberto Castagna
COPD is a worsening condition that leads to a pathologic degeneration of the respiratory system. It represents one of the most important causes of mortality and morbidity in the world, and it is characterized by the presence of associated comorbidity. This article analyzes gastroesophageal reflux disease (GERD) and low back pain (LBP) in patients with COPD and tries to produce anatomo-clinical considerations on the reasons of the presence of these comorbidities. The considerations of the authors are based on the anatomic functions and characteristics of the respiratory diaphragm that are not always considered, from which elements useful to comprehend the symptomatic status of the patient can be deduced, finally improving the therapeutic approach...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29390957/streptococcus-agalactiae-meningoencephalitis-associated-with-gastroesophageal-reflux-disease-and-chronic-proton-pump-inhibitors-use-in-a-9%C3%A2-month-old-infant-a-case-report
#7
Victoria Bîrluţiu, Codruța Mihaela Luca, Rareș-Mircea Bîrluțiu
BACKGROUND: Streptococcus agalactiae (Group B Streptococcus) is recognized as the etiologic agent of newborn and infant meningitis, aged up to 90 days, starting from the colonization of the maternal genital or gastrointestinal tract, but it is rarely responsible for meningitis in old infants. CASE PRESENTATION: We present the case of a 9 month-old infant diagnosed with S. agalactiae meningoencephalitis associated with chronic gastroesophageal reflux disease treated with a proton pump inhibitor (PPI)...
February 1, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29327685/the-role-of-pepsin-in-the-laryngopharyngeal-reflux
#8
Katarzyna Kowalik, Antoni Krzeski
Laryngopharyngeal reflux (LPR) is a common defect among laryngological and phoniatric patients. Although LPR is categorized as a superficial gastroesophageal reflux disease (GERD), differential diagnosis should treat these two diseases separately. LPR symptoms can be assessed in the interview using as a tool the reflux symptom index (RSI). In addition, changes in the larynx that occur during LPR might be seen during laryngoscopy and classified according to the reflux finding score (RFS). One of the main mucosal irritants in LPR is pepsin which digests proteins and impairs the functions of the upper respiratory tract cells by affecting carbonate anhydrase (CAIII) and the Sep 70 protein...
December 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29288311/antireflux-surgery-in-the-usa-influence-of-surgical-volume-on-perioperative-outcomes-and-costs-time-for-centralization
#9
Francisco Schlottmann, Paula D Strassle, Marco G Patti
BACKGROUND: Few studies have analyzed the relationship between surgical volume and outcomes after antireflux procedures. The aim of this study was to determine the effect of surgical volume on postoperative results and costs for patients undergoing surgery for gastroesophageal reflux disease. METHODS: We analyzed the National Inpatient Sample (period 2000-2013). Adult patients (≥18 years old) with gastroesophageal reflux disease who underwent fundoplication were included...
December 30, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29175370/atopy-is-associated-with-age-at-asthma-onset-in-elderly-patients
#10
Rosana Câmara Agondi, Mayra Coutinho Andrade, Priscila Takejima, Marcelo Vivolo Aun, Jorge Kalil, Pedro Giavina-Bianchi
BACKGROUND: Asthma in the elderly population (60 years of age and older) is frequently underdiagnosed, as well as atopy. Atopy, although more prevalent in younger patients, can be a major cause of asthma in the elderly. Chronic obstructive pulmonary disease (COPD) and cardiovascular disease are common differential diagnoses, especially in elderly smokers. OBJECTIVE: The objective of this study was to assess atopy and comorbidities in elderly patients with asthma...
November 23, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29127961/fundoplication
#11
REVIEW
Bethany J Slater, Steven S Rothenberg
Gastroesophageal reflux disease (GERD) is a common condition in infants. Symptoms from pathologic GERD include regurgitation, irritability when feeding, failure to thrive, and respiratory problems. Treatment typically starts with dietary modifications and postural changes. Antireflux medications may then be added. Indications for operative management in neonates and infants include poor weight gain, failure to thrive, acute life-threatening events, and continued respiratory symptoms. Laparoscopic Nissen fundoplication has become the standard of care for surgical treatment of children with GERD...
December 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/29109876/debut-of-gastroesophageal-reflux-concomitant-with-administration-of-sublingual-immunotherapy
#12
Jacob Juel
Gastroesophageal reflux disease (GORD) is an often debilitating condition characterised by retrograde flow of content from stomach into the oesophagus, where the low pH of the stomach acid irritates the mucosa of the oesophagus. The most dominant symptoms in GORD are pyrosis, regurgitation, and dysphagia. Sublingual immunotherapy (SLIT) was first described in 1986. Following this description, the use has greatly increased in the treatment of allergic rhinitis, as an alternative to subcutaneously administered immunotherapy...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29103790/laparoscopic-gastroesophageal-dissociation-in-neurologically-impaired-children-with-gastroesophageal-reflux-disease
#13
Jonathan H DeAntonio, Dan W Parrish, Shannon F Rosati, Claudio Oiticica, David A Lanning
PURPOSE: Neurologically impaired children with severe gastroesophageal reflux disease (GERD) are a challenging group of patients. We theorized that a laparoscopic gastroesophageal dissociation (LGED) may decrease reflux-related readmissions and healthcare visits, and improve quality of life (QOL) for them and their caregivers. METHODS: A retrospective review was performed on our pediatric patients that underwent an LGED along with a caregiver survey from 2013 to 2017...
October 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29080708/classification-of-cough-as-a-symptom-in-adults-and-management-algorithms-chest-guideline-and-expert-panel-report
#14
Richard S Irwin, Cynthia L French, Anne B Chang, Kenneth W Altman
BACKGROUND: We performed systematic reviews using the population, intervention, comparison, outcome (PICO) format to answer the following key clinical question: Are the CHEST 2006 classifications of acute, subacute and chronic cough and associated management algorithms in adults that were based on durations of cough useful? METHODS: We used the CHEST Expert Cough Panel's protocol for the systematic reviews and the American College of Chest Physicians (CHEST) methodological guidelines and Grading of Recommendations Assessment, Development, and Evaluation framework...
November 10, 2017: Chest
https://www.readbyqxmd.com/read/28978214/strategies-to-manage-costs-in-idiopathic-pulmonary-fibrosis
#15
Gary M Owens
Idiopathic pulmonary fibrosis (IPF) is a diagnostically challenging disease. Clinicians are faced with the need to exclude alternative diagnoses, limited treatment and management guidelines, and few treatment options. Patients with IPF have significantly increased healthcare usage compared with similar patients without the disease. Medicare estimates for this disease are as high as $3 billion, not including cost of treatment. The disease, characterized by worsening dyspnea, declining lung function, nonspecific respiratory symptoms, and a varied clinical course randomly punctuated by episodes of acute exacerbations, is also accompanied by a host of comorbid conditions that contribute significantly to increased healthcare usage and cost...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28978212/overview-of-idiopathic-pulmonary-fibrosis-ipf-and-evidence-based-guidelines
#16
Roozbeh Sharif
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive form of interstitial lung disease (ILD), characterized by fibrosis and worsening lung function, that primarily occurs in those 50 years and older. Various causes including genetic susceptibility, environmental risk factors, and exposures have been suggested in the literature. All of these cause repetitive micro-injury to the lung tissue and vasculature, which triggers a cascade of inflammatory response and fibrosis. Symptoms are nonspecific and most patients present several years after the initial radiographic changes occur...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28974837/laryngopharyngeal-reflux-disease-lprd
#17
Nizama Salihefendic, Muharem Zildzic, Emir Cabric
INTRODUCTION: Laryngopharyngeal reflux disease (LPRD) referes to an inflammatory reaction of the mucous membrane of pharynx, larynx and other associated respiratory organs, caused by a reflux of stomach contents into the esophagus. LPRD is considered to be a relatively new clinical entity with a vast number of clinical manifestations which are treated through different fields of medicine, often without a proper diagnosis. In gastroenterology it is still considered to be a manifestation of GERD, which stands for gastroesophageal reflux disease...
June 2017: Medical Archives
https://www.readbyqxmd.com/read/28942883/gastroesophageal-reflux-disease-an-important-consideration-for-respiratory-disorders
#18
EDITORIAL
Akio Niimi
No abstract text is available yet for this article.
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28889139/bohring-opitz-syndrome-a-case-of-a-rare-genetic-disorder
#19
N Visayaragawan, N Selvarajah, H Apparau, V Kamaru Ambu
The diagnostic challenge of Bohring-Opitz Syndrome, a rare genetic disorder has haunted clinicians for ages. Our patient was born at term via caesarean-section with a birth weight of 1.95 kilograms. She had mild laryngomalacia, gastroesophageal reflux disease and seizures. Physical signs included microcephaly, hemangioma, low set ears, cleft palate, micrognatia and the typical BOS posture. Chromosomal analysis showed 46 xx -Bohring-Opitz Syndrome overlapped with C- syndrome. Goal-directed holistic care with integration of parent/carer training was started very early...
August 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28828055/gas-reflux-in-children-with-normal-acid-exposure-of-the-oesofagus
#20
Felicia Galos, Catalin Boboc, Mihaela Balgradean
The clinical manifestations of non-erosive gastroesophageal reflux disease (NERD) are multiple and heterogeneous, and differ according to age and individual susceptibility. Weakly acidic reflux and the presence of gas in the refluxate could be relevant in the pathogenesis of symptoms. We present the case of a 3-year and 5-month-old child who came to the hospital with recurrent paroxysmal manifestations without fever assessed. The positive diagnosis was made using pH-metry associated with multichannel intraluminal impedance and glucose respiratory breath test, a new technique that allows positive diagnosis as well as establishes important connections regarding gas reflux and clinical symptomatology described by the patient...
December 2016: Mædica
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