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Gastroesophageal reflux respiratory disease

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https://www.readbyqxmd.com/read/27868292/patterns-of-reflux-in-gastroesophageal-reflux-disease-in-pediatric-population-of-new-south-wales
#1
Sarath Kumar Narayanan, Ralph Clinton Cohen, Jonathan Saul Karpelowsky
This study is to determine the association of ambulatory pH monitoring (24hr pH) with symptoms of gastroesophageal reflux and its other investigations. The clinical and epidemiological profiles of subjects referred for reflux disorders are also studied. Symptoms or group of symptoms, profiles and prior investigations of 1259 consecutive pediatric subjects (with 1332 24hr pH studies performed) referred for evaluation of reflux disorders between 1988 and 2012 were retrospectively studied. Chi-square or fisher exact test was used for hypothesis testing, student t-test for the comparison of means and the Wilcoxon rank-sum test for comparing medians of continuous variables...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27867686/widespread-use-of-gastric-acid-inhibitors-in-infants-are-they-needed-are-they-safe
#2
REVIEW
Mark Safe, Wei H Chan, Steven T Leach, Lee Sutton, Kei Lui, Usha Krishnan
Gastroesophageal reflux is a common phenomenon in infants, but the differentiation between gastroesophageal reflux and gastroesophageal reflux disease can be difficult. Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related. Despite this, gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used, often without objective evidence or investigations to guide treatment. Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis...
November 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27865877/cough-in-the-athlete-chest-guideline-and-expert-panel-report
#3
Louis-Philippe Boulet, Julie Turmel, Richard S Irwin
BACKGROUND: Cough is a common symptom experienced by athletes, particularly after exercise. We performed a systematic review to assess in this population: 1) the main etiologies of acute and recurrent cough, either exercise-induced or not; 2) how it is assessed; and 3) how cough is treated in this population. From the systematic review, suggestions for management were developed. METHOD: ology: This review was done according to the CHEST methodological guidelines and GRADE framework up to April 2015...
November 16, 2016: Chest
https://www.readbyqxmd.com/read/27858520/fundoplication-for-gastroesophageal-reflux-disease-tips-for-success
#4
Marco G Patti, Francisco Schlottmann, Timothy M Farrell
Gastroesophageal reflux disease affects almost 20% of the population in the United States. Today, proton pump inhibitors are the most frequently prescribed drugs, with an estimated cost of 10 billion dollars per year. Although these medications control heartburn in the majority of patients, other symptoms such as regurgitation and respiratory symptoms often are not controlled, particularly in patients with large hiatal hernias. In these patients a properly performed laparoscopic fundoplication controls esophageal and extraesophageal symptoms and avoids life-long medical therapy...
November 18, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27852360/-changes-and-implications-of-esophageal-function-in-patients-with-chronic-cough-induced-by-gastroesophageal-reflux
#5
X H Xu, L Yu, Q Chen, Y Huang, H H Sun, L S Yi, S C Xu, H J Lyu, Z M Qiu
Objective: To explore the changes in the esophageal function and their association with the therapeutic outcome in patients with gastroesophageal reflux-induced chronic cough (GERC). Methods: One hundred thirty-five patients with definite GERC consecutively referred to our respiratory clinic were recruited into the study between January 2012 and August 2015.Cough was due to acid reflux in 81 patients and non-acid reflux in 54 patients, with the favorable response to the standard antireflux therapy in 88 patients and to the intensified antireflux treatment in 47 patients...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27820755/the-impact-of-breast-milk-respiratory-insufficiency-and-gerd-on-enteral-feeding-in-infants-with-omphalocele
#6
Shelly Haug, Shawn St Peter, Sandhya Ramlogan, Donna Goff, Donna Thorpe, Andrew Hopper, Joanne Baerg
OBJECTIVES: The aim of this study was to document the process of achieving full enteral feeding in infants with omphalocele and to identify factors that affect feeding success. METHODS: After Institutional Review Board approval (5100169), 123 infants with omphalocele, born between 1993 and 2011 were reviewed. Mortalities were excluded. All survivors had complete follow-up. Variables suspected to impact enteral feeding in infants with non-giant versus giant omphalocele were compared...
November 5, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27766409/laser-tracheobronchoplasty-a-novel-technique-for-the-treatment-of-symptomatic-tracheobronchomalacia
#7
Paul Castellanos, Manjunath Mk, Ihab Atallah
The management of tracheobronchomalacia is a very challenging problem with few treatment options. This study aims to evaluate the outcomes of a novel surgical treatment for membranous tracheobronchomalacia. A consecutive series of patients with tracheobronchomalacia were treated with two to three holmium laser scarring surgeries of the hyperdynamic tracheal and bronchial walls for the purpose of stiffening them through fibrosis. Patients filled out a Dyspnea Index questionnaire before and after treatment. Ten patients were treated for their tracheobronchomalacia with a mean age of 54 years...
October 20, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27759910/laryngopharyngeal-reflux-and-herpes-simplex-virus-type-2-are-possible-risk-factors-for-adult-onset-recurrent-respiratory-papillomatosis-prospective-case-control-study
#8
M Formánek, D Jančatová, P Komínek, P Matoušek, K Zeleník
OBJECTIVE: The human papillomavirus (HPV) causes recurrent respiratory papillomatosis (RRP). Although HPV prevalence is high, the incidence of papillomatosis is low. Thus, factors other than HPV infection probably contribute to RRP. This study investigated whether patients with papillomatosis are more often infected with herpes simplex virus type 2 and chlamydia trachomatis (ChT) and whether laryngopharyngeal reflux (LPR) occurs in this group of patients more often. DESIGN: Prospective case-control study...
October 19, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27755341/prevalence-of-malnutrition-and-feeding-difficulties-in-children-with-esophageal-atresia
#9
Jessica Menzies, Jennifer Hughes, Steven Leach, Yvonne Belessis, Usha Krishnan
OBJECTIVES: Growth and feeding problems have been described in children with Esophageal Atresia (EA). Ongoing gastrointestinal and respiratory complications such as Gastroesophageal Reflux Disease (GERD), esophageal dysmotility, strictures and respiratory infections may contribute. The aim of the study was to document the prevalence of malnutrition and feeding difficulties and examine predictive factors which may influence feeding and growth in children attending a multidisciplinary EA clinic in Sydney Australia...
October 13, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27739267/prevailing-practices-for-the-management-of-dry-cough-in-india-a-questionnaire-based-survey
#10
Rakesh Pore, Swati Biswas, Srirupa Das
PURPOSE: The aim of the survey was to understand the prevailing practice pattern for the management of dry cough among primary care physicians in Indian clinical setting. MATERIAL AND METHODS: This single visit, cross-sectional, non-interventional, interview based physician survey was conducted over a period of 3 months where 500 registered physicians with at least 6 months of clinical practice and willing to participate in the survey were interviewed in their clinic or hospital from June to August 2015...
June 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27703389/ineffective-esophageal-motility-and-the-vagus-current-challenges-and-future-prospects
#11
Ji-Hong Chen
Ineffective esophageal motility (IEM) is characterized by low to very low amplitude propulsive contractions in the distal esophagus, hence primarily affecting the smooth muscle part of the esophagus. IEM is often found in patients with dysphagia or heartburn and is commonly associated with gastroesophageal reflux disease. IEM is assumed to be associated with ineffective bolus transport; however, this can be verified using impedance measurements or evaluation of a barium coated marshmallow swallow. Furthermore, water swallows may not assess accurately the motor capabilities of the esophagus, since contraction amplitude is strongly determined by the size and consistency of the bolus...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27668224/bronchial-reacutization-and-gastroesophageal-reflux-is-there-a-potential-clinical-correlation
#12
Carlo Pomari, Luisa Mauroner, Simona Paiano, Luca Rosario Assante, Luca Bertolaccini, Giacomo Ruffo, Paride Mainardi, Paolo Bocus, Andrea Geccherle, Sergio Ivan Albanese, Stefano Ciaffoni
BACKGROUND: Pepsin plays a role in gastroesophageal reflux (GER). Aims of this study were to verify if pepsin could be the cause of frequent bronchial exacerbations and to check if the persistence of chronic respiratory symptoms were correlated with pre-existing respiratory diseases. METHODS: From January to May 2016, 42 patients underwent a diagnostic bronchoscopy. All patients had a history of at least one bronchial exacerbation during the previous year. Bronchial lavage fluid specimens were obtained...
August 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27579823/biomarkers-predictive-of-exacerbations-in-the-spiromics-and-copdgene-cohorts
#13
Jason D Keene, Sean Jacobson, Katerina Kechris, Gregory L Kinney, Marilyn G Foreman, Claire M Doerschuk, Barry J Make, Jeffrey L Curtis, Stephen I Rennard, R Graham Barr, Eugene R Bleecker, Richard E Kanner, Eric C Kleerup, Nadia N Hansel, Prescott G Woodruff, MeiLan K Han, Robert Paine Iii, Fernando J Martinez, Russell P Bowler, Wanda K O'Neal
RATIONALE: COPD exacerbations are associated with disease progression, higher healthcare cost, and increased mortality. Published predictors of future exacerbations include previous exacerbation, airflow obstruction, poor overall health, home oxygen use, and gastroesophageal reflux. The value of adding blood biomarkers to clinical variables to predict exacerbations remains unproven. METHODS: Subjects from SPIROMICS (n=1544) and COPDGene (n=602) cohorts had 90 plasma or serum candidate proteins measured on study entry using Myriad-RBM multiplex panels...
August 31, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27574881/combined-multichannel-intraluminal-impedance-and-ph-measurement-in-detecting-gastroesophageal-reflux-disease-in-children
#14
Mark Safe, Jemma Cho, Usha Krishnan
OBJECTIVE: The aim of the study was to evaluate and compare multichannel intraluminal impedance-pH (MII-pH) monitoring with standard investigations including pH testing for detecting gastroesophageal reflux disease (GERD) in children. METHODS: A retrospective review of all MII-pH studies performed between July 2007 and March 2013 at Sydney Children's Hospital. Results from MII-pH testing, esophagogastroduodenoscopy (EGD), barium meal and pepsin assay, symptoms, underlying comorbidities, age, and medication usage were evaluated...
November 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27545027/-cluster-analysis-of-the-clinical-presentations-in-patients-with-moderate-to-severe-obstructive-sleep-apnea-syndrome-and-its-significance
#15
S Tang, X F Zhou, K Hu, L F Xu, J X Yu, H M Li
OBJECTIVE: To analyze subtypes of the clinical presentation of moderate-to-severe obstructive sleep apnea syndrome (OSAS) by cluster analysis and to explore its significance. METHODS: A retrospective analysis was performed on the data of adult moderate-to-severe OSAS patients, which were diagnosed in Respiratory Department, Renmin Hospital of Wuhan University from October 2012 to October 2015. Fifteen kinds of clinical presentations were included in the cluster analysis, and analysis of characteristic of each cluster was then performed after category...
August 9, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27544833/association-between-respiratory-events-and-nocturnal-gastroesophageal-reflux-events-in-patients-with-coexisting-obstructive-sleep-apnea-and-gastroesophageal-reflux-disease
#16
Nattapong Jaimchariyatam, Warangkana Tantipornsinchai, Tayard Desudchit, Sutep Gonlachanvit
BACKGROUND: Literature has addressed the increased prevalence of gastroesophageal reflux disease (GERD) in obstructive sleep apnea (OSA). Significant improvement of GERD has been found after OSA treatment. However, precise mechanisms underlying this correlation remain unclear. We examined the association between nocturnal gastroesophageal reflux (GER) and sleep events in patients with coexisting OSA and GERD. METHODS: A case-crossover study among 12 patients with coexisting moderate-severe OSA and GERD was conducted...
June 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27532103/diagnosis-and-anti-reflux-therapy-for-gerd-with-respiratory-symptoms-a-study-using-multichannel-intraluminal-impedance-ph-monitoring
#17
Chao Zhang, Jimin Wu, Zhiwei Hu, Chao Yan, Xiang Gao, Weitao Liang, Diangang Liu, Fei Li, Zhonggao Wang
BACKGROUND/AIMS: Respiratory symptoms are often associated with gastroesophageal reflux disease (GERD). Although the role of multichannel intraluminal impedance-pH (MII-pH) monitoring in GERD is clear, little is known regarding the characteristics of patients with respiratory symptoms based on MII-pH monitoring and anti-reflux therapy. We evaluated a cohort of GERD patients to identify the MII-pH parameters of GERD-related respiratory symptoms and to assess the anti-reflux therapy outcomes...
2016: PloS One
https://www.readbyqxmd.com/read/27521738/therapeutic-approach-to-adult-fibrotic-lung-diseases
#18
Ayodeji Adegunsoye, Mary E Strek
Among the interstitial lung diseases (ILD), idiopathic pulmonary fibrosis (IPF), chronic hypersensitivity pneumonitis and fibrotic connective tissue disease related ILD are associated with a worse prognosis with death occurring both from respiratory failure and serious associated co-morbidities. The recent development and approval of the antifibrotic agents nintedanib and pirfenidone, both of which reduced the rate of decline in lung function in patients with IPF in clinical trials, offer hope that it may be possible to alter the increased mortality associated with IPF...
August 10, 2016: Chest
https://www.readbyqxmd.com/read/27516725/clinical-utility-of-bronchoalveolar-lavage-pepsin-in-diagnosis-of-gastroesophageal-reflux-among-wheezy-infants
#19
Ahmed Fathi Abdallah, Tarek El-Desoky, Khalid Fathi, Wagdy Fawzi Elkashef, Ahmed Zaki
Background. There is no gold standard test for diagnosis of gastroesophageal reflux disease (GERD) associated infantile wheezing. Objectives. To evaluate the value of bronchoalveolar lavage (BAL) pepsin assay in diagnosis of GERD in wheezy infants. Methods. Fifty-two wheezy infants were evaluated for GERD using esophageal combined impedance-pH (MII-pH) monitoring, esophagogastroduodenoscopy with esophageal biopsies, and BAL pepsin. Tracheobronchial aspirates from 10 healthy infants planned for surgery without history of respiratory problems were examined for pepsin...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27492541/identification-of-five-clusters-of-comorbidities-in-a-longitudinal-japanese-chronic-obstructive-pulmonary-disease-cohort
#20
Shotaro Chubachi, Minako Sato, Naofumi Kameyama, Akihiro Tsutsumi, Mamoru Sasaki, Hiroki Tateno, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku
BACKGROUND AND OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from various comorbidities. Recently, cluster analysis has been proposed to examine the phenotypic heterogeneity in COPD. In order to comprehensively understand the comorbidities of COPD in Japan, we conducted multicenter, longitudinal cohort study, called the Keio COPD Comorbidity Research (K-CCR). In this cohort, comorbid diagnoses were established by both objective examination and review of clinical records, in addition to self-report...
August 2016: Respiratory Medicine
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