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Pancreatic acinar cells

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https://www.readbyqxmd.com/read/29675407/pancreatic-aquaporin-7-a-novel-target-for-anti-diabetic-drugs
#1
REVIEW
Leire Méndez-Giménez, Silvia Ezquerro, Inês V da Silva, Graça Soveral, Gema Frühbeck, Amaia Rodríguez
Aquaporins comprise a family of 13 members of water channels (AQP0-12) that facilitate a rapid transport of water across cell membranes. In some cases, these pores are also permeated by small solutes, particularly glycerol, urea or nitric oxide, among other solutes. Several aquaporins have been identified in the pancreas, an exocrine and endocrine organ that plays an essential role in the onset of insulin resistance and type 2 diabetes. The exocrine pancreas, which accounts for 90% of the total pancreas, secretes daily large volumes of a near-isotonic fluid containing digestive enzymes into the duodenum...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29672153/p21-activated-kinase4-in-pancreatic-acini-is-activated-by-gi-hormones-growth-factors-by-novel-signaling-and-is-needed-to-stimulate-secretory-growth-cascades
#2
Irene Ramos-Alvarez, Robert T Jensen
p21-activated kinases(PAKs) are highly conserved serine/threonine protein kinases, which are divided into two groups:Group-I(PAKs1-3) and Group-II(PAKs4-6). In various tissues, Group-II PAKs play important roles in cytoskeletal dynamics, cell growth as well as neoplastic development/progression. However, little is known about Group-II PAKs role in a number of physiological events including their ability to be activated by gastrointestinal(GI) hormones/neurotransmitters/growth-factors(GFs). We used rat pancreatic acini to explore the ability of GI-hormones/neurotransmitters/GFs to activate Group-II-PAKs and the signaling cascades involved...
April 19, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29669919/mutations-in-the-pancreatic-secretory-enzymes-cpa1-and-cpb1-are-associated-with-pancreatic-cancer
#3
Koji Tamura, Jun Yu, Tatsuo Hata, Masaya Suenaga, Koji Shindo, Toshiya Abe, Anne MacGregor-Das, Michael Borges, Christopher L Wolfgang, Matthew J Weiss, Jin He, Marcia Irene Canto, Gloria M Petersen, Steven Gallinger, Sapna Syngal, Randall E Brand, Anil Rustgi, Sara H Olson, Elena Stoffel, Michele L Cote, George Zogopoulos, James B Potash, Fernando S Goes, Richard W McCombie, Peter P Zandi, Mehdi Pirooznia, Melissa Kramer, Jennifer Parla, James R Eshleman, Nicholas J Roberts, Ralph H Hruban, Alison Patricia Klein, Michael Goggins
To evaluate whether germline variants in genes encoding pancreatic secretory enzymes contribute to pancreatic cancer susceptibility, we sequenced the coding regions of CPB1 and other genes encoding pancreatic secretory enzymes and known pancreatitis susceptibility genes ( PRSS1 , CPA1 , CTRC , and SPINK1 ) in a hospital series of pancreatic cancer cases and controls. Variants in CPB1 , CPA1 (encoding carboxypeptidase B1 and A1), and CTRC were evaluated in a second set of cases with familial pancreatic cancer and controls...
April 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666669/-egfr-amplification-induces-sensitivity-to-anti-egfr-therapy-in-pancreatic-acinar-cell-carcinoma
#4
Corentin Richard, Julie Niogret, Romain Boidot, Francois Ghiringhelli
Pancreatic acinar cell carcinoma (PACC) is a rare cancer. When the tumor is metastatic, few therapeutic options are available. Precision medicine using next-generation sequencing is defined by the administration of drugs based on the tumor genetic mutations. The usage of precision medicine for finding new therapeutic options for rare cancers is an emerging field. We have reported here the case of a patient bearing a multitreated metastatic PACC. This patient underwent somatic and constitutional exome analyses...
April 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29659906/increased-chromogranin-a-positive-hormone-negative-cells-in-chronic-pancreatitis
#5
Abu Saleh Md Moin, Megan Cory, Jennifer Choi, Allison Ong, Sangeeta Dhawan, Sarah M Dry, Peter Butler, Robert Rizza, Alexandra Butler
Context: Chronic pancreatitis (CP) is characterized by inflammation, fibrosis and a loss of pancreatic acinar cells which can result in exocrine and eventually endocrine deficiency. Pancreatitis has been reported to induce formation of new endocrine cells (neogenesis) in mice. Our recent data has implicated Chromogranin A-positive hormone negative (CPHN) cells as potential evidence of neogenesis in humans. Objective: We sought to establish if CPHN cells were more abundant in chronic pancreatitis in humans...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29659083/hepatobiliary-and-pancreatic-primary-acinar-cell-carcinoma-of-the-liver-showing-good-response-to-chemotherapy
#6
M E Laino, M Ragucci, D S Klimstra, L Mannelli
No abstract text is available yet for this article.
May 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29626097/oxidative-stress-alters-mitochondrial-bioenergetics-and-modifies-pancreatic-cell-death-independently-of-cyclophilin-d-resulting-in-an-apoptosis-to-necrosis-shift
#7
Jane A Armstrong, Nicole J Cash, Yulin Ouyang, Jack C Morton, Michael Chvanov, Diane Latawiec, Muhammad Awais, Alexei V Tepikin, Robert Sutton, David N Criddle
Mitochondrial dysfunction lies at the core of acute pancreatitis (AP). Diverse AP stimuli induce Ca2+ -dependent formation of the mitochondrial permeability transition pore (MPTP), a solute channel modulated by cyclophilin D (CypD), whose formation causes ATP depletion and necrosis. Oxidative stress reportedly triggers MPTP formation and is elevated in clinical AP, but how reactive oxygen species influence cell death is unclear. Here, we assessed potential MPTP involvement in oxidant-induced effects on pancreatic acinar cell bioenergetics and fate...
April 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29620455/pancreatitis-is-an-important-feature-of-broilers-suffering-from-inclusion-body-hepatitis-leading-to-dysmetabolic-conditions-with-consequences-for-zootechnical-performance
#8
Miguel Matos, Károly Dublecz, Beatrice Grafl, Dieter Liebhart, Michael Hess
The aim of the present study was to further unravel the pathophysiologic mechanisms of inclusion body hepatitis (IBH). In a first trial, the susceptibility of specific-pathogen-free (SPF) broilers to fowl aviadenovirus (FAdV) infections was investigated. Regardless of viral dose, route of infection, and susceptibility to disease on day 1, the 3-week-old SPF broilers showed resistance to IBH, with no mortality being recorded throughout the experiment. In a second trial, SPF broilers were orally infected at 3 weeks of age with a FAdV-E strain, and their digestive and metabolic processes were monitored...
March 2018: Avian Diseases
https://www.readbyqxmd.com/read/29599125/establishment-of-human-pluripotent-stem-cell-derived-pancreatic-%C3%AE-like-cells-in-the-mouse-pancreas
#9
Haiting Ma, Katherine J Wert, Dmitry Shvartsman, Douglas A Melton, Rudolf Jaenisch
Type 1 diabetes is characterized by autoimmune destruction of β cells located in pancreatic islets. However, tractable in vivo models of human pancreatic β cells have been limited. Here, we generated xenogeneic human pancreatic β-like cells in the mouse pancreas by orthotopic transplantation of stem cell-derived β (SC-β) cells into the pancreas of neonatal mice. The engrafted β-like cells expressed β cell transcription factors and markers associated with functional maturity. Engrafted human cells recruited mouse endothelial cells, suggesting functional integration...
March 29, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29594979/anti-inflammatory-and-antioxidant-effects-of-captopril-compared-to-methylprednisolone-in-l-arginine-induced-acute-pancreatitis
#10
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Omnia B Hamada
BACKGROUND: Acute pancreatitis (AP) is an inflammatory disease mediated by damage in acinar cells and pancreatic inflammation with infiltration of leukocytes. The pancreatic renin-angiotensin system may play an important role in the pathogenesis of AP. AIM: The present study aimed to investigate the possible protective role of captopril (CAP), an angiotensin-converting enzyme inhibitor, in attenuating L-arginine-induced AP rat model and to elucidate the underlying molecular mechanisms...
March 29, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29594173/acinar-cell-cystadenoma-a-rarity-in-advanced-von-hippel-lindau-disease-a-case-report
#11
Tim Fahlbusch, Andrea Tannapfel, Waldemar Uhl, Chris Braumann
Background: Von Hippel-Lindau (VHL) disease may occur at various localisations which can be both intra- and extrapancreatic as well as challenging to diagnose by medical imaging. Case Report: A positron emission tomography/magnetic resonance imaging in a 40-year-old woman was performed to monitor a haemangioblastoma. Additionally, it showed findings which were considered to be a pancreatic neuroendocrine tumour (pNET) and retroumbilical metastasis. The suspected metastasis was laparoscopically resected; however, pathological evaluation did not lead to a clear categorisation...
February 2018: Visceral Medicine
https://www.readbyqxmd.com/read/29589836/laser-induced-calcium-oscillations-in-fluorescent-calcium-imaging
#12
János Vincze, Nikolett Geyer, Gyula Diszházi, László Csernoch, Tamás Bíró, István Jóna, Beatrix Dienes, János Almássy
Phototoxicity is the most common problem investigators may encounter when performing live cell imaging. It develops due to excess laser exposure of cells loaded with fluorophores and can lead to often overlooked but significant artifacts, such as massive increase of intracellular Ca2+ concentration, which would make data interpretation problematic. Because information about laser- and dye-related changes in cytoplasmic calcium concentration is very limited, we aimed to describe this phenomenon to help investigators using laser scanning confocal microscopy in a non-invasive way...
March 28, 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29580319/liver-and-pancreas-do-similar-embryonic-development-and-tissue-organization-lead-to-similar-mechanisms-of-tumorigenesis
#13
Elsa Ghurburrun, Ivan Borbath, Frédéric P Lemaigre, Patrick Jacquemin
Liver and pancreas are closely associated organs which share a common embryological origin. They display amphicrine properties and have similar exocrine organization with parenchymal cells, namely hepatocytes and acinar cells, secreting bile and pancreatic juice into the duodenum via a converging network of bile ducts and pancreatic ducts. Here we compare and highlight the similarities of molecular mechanisms leading to liver and pancreatic cancer development. We suggest that unraveling tumor development in an organ may provide insight into our understanding of carcinogenesis in the other organ...
March 26, 2018: Gene Expression
https://www.readbyqxmd.com/read/29574522/number-of-acinar-cells-at-the-pancreatic-stump-predicts-pancreatic-fistula-after-pancreaticoduodenectomy
#14
Naoki Umezaki, Daisuke Hashimoto, Shigeki Nakagawa, Yuki Kitano, Kensuke Yamamura, Akira Chikamoto, Fujio Matsumura, Hideo Baba
PURPOSE: To establish if the number of pancreatic acinar cells at the pancreatic cut end is a predictor of postoperative pancreatic fistula (POPF). METHODS: The number of acinar cells was assessed histologically in 121 consecutive patients who underwent pancreaticoduodenectomy (PD) between April, 2012 and July, 2016. RESULTS: POPF developed in 23 of the 121 patients. Univariate analysis revealed that male sex, long operating time, high volume of blood loss, soft remnant pancreas, large pancreatic duct, and the number of pancreatic acinar cells were significantly associated with POPF...
March 24, 2018: Surgery Today
https://www.readbyqxmd.com/read/29572224/il-22ra1-stat3-signaling-promotes-stemness-and-tumorigenicity-in-pancreatic-cancer
#15
Weizhi He, Jinghua Wu, Juanjuan Shi, Yan-Miao Huo, Wentao Dai, Jing Geng, Ping Lu, Min-Wei Yang, Yuan Fang, Wei Wang, Zhi-Gang Zhang, Aida Habtezion, Yong-Wei Sun, Jing Xue
Chronic inflammation is a feature of pancreatic cancer, but little is known about how immune cell or immune cell-related signal affects pancreatic cancer stemness and development. Our previous work showed that IL-22/IL-22RA1 plays a vital role in acute and chronic pancreatitis progression by mediating crosstalk between immune cells and acinar cells or stellate cells, respectively. Here we find IL-22RA1 is highly but heterogeneously expressed in pancreatic cancer cells, with high expression associated with poor prognosis of pancreatic cancer patients...
March 23, 2018: Cancer Research
https://www.readbyqxmd.com/read/29548035/specific-storage-of-glycoconjugates-with-terminal-%C3%AE-galactosyl-moieties-in-the-exocrine-pancreas-of-fabry-disease-patients-with-blood-group-b
#16
Jitka Rybová, Ladislav Kuchar, Helena Hulková, Befekadu Asfaw, Robert Dobrovolný, Jakub Sikora, Vladimír Havlícek, Ludovít Škultéty, Jana Ledvinová
Blood group B glycosphingolipids (B-GSLs) are substrates of the lysosomal alpha-galactosidase A (AGAL). Similar to its major substrate - globotriaosylceramide (Gb3Cer) - B-GSLs are not degraded and accumulate in the cells of patients affected by an inherited defect of AGAL activity (Fabry disease - FD).The pancreas is a secretory organ known to have high biosynthesis of blood group GSLs. Herein, we provide a comprehensive overview of the biochemical and structural abnormalities in pancreatic tissue from two male FD patients with blood group B...
March 14, 2018: Glycobiology
https://www.readbyqxmd.com/read/29541382/mir-352-participates-in-the-regulation-of-trypsinogen-activation-in-pancreatic-acinar-cells-by-influencing-the-function-of-autophagic-lysosomes
#17
Zonggong Song, Yongming Huang, Chao Liu, Ming Lu, Zhituo Li, Bei Sun, Weihui Zhang, Dongbo Xue
This study was performed to screen miRNAs and mRNAs that are differentially expressed during trypsinogen activation in acute pancreatitis and to verify their role in the process of trypsinogen activation. The function enrichment analysis showed that the functions of miR-352 and its regulatory targets lysosome-associated membrane protein 2 (LAMP2) and cathepsin L1 (CTSL1) were lysosome related. The results of the verification experiment showed that in the TLC-S-treated AR42J (pancreatic cell line) cells, miR-352 expression increased, expression levels of LAMP2 and CTSL1 were significantly reduced, trypsinogen activation was increased, and the autophagy pathway was blocked...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29538343/blocking-%C3%AE-%C3%A2-%C3%AE-%C3%A2-adrenergic-signaling-reduces-dietary-fat-absorption-by-suppressing-expression-of-pancreatic-lipase-in-high-fat-fed-mice
#18
Kyunghwa Baek, Danbi Park, Hyo Rin Hwang, Seong-Gon Kim, Heesu Lee, Jeong-Hwa Baek
We investigated whether β-adrenergic antagonists attenuates dietary fat absorption through the regulation of pancreatic lipase (PNLIP) expression in pancreatic acinar cells in the context of high fat diet feeding. Male six-week-old C57BL/6 mice were assigned into an ad libitum fed control diet (CON) and a high fat diet (HIGH). Within each diet group, subgroups of mice were treated with vehicle (VEH) or propranolol, a β-adrenergic antagonist (BB). Over 12 weeks, body weight gain observed in HIGHVEH was mitigated in HIGHBB (+103% vs...
March 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29535635/die-rna-a-reproducible-strategy-for-the-digestion-of-normal-and-injured-pancreas-isolation-of-pancreatic-cells-from-genetically-engineered-mouse-models-and-extraction-of-high-quality-rna
#19
Mohamad Assi, Nicolas Dauguet, Patrick Jacquemin
The isolation of ribonucleic acid (RNA) suitable for gene expression studies is challenging in the pancreas, due to its high ribonuclease activity. This is even more complicated during pancreatitis, a condition associated with inflammation and fibrosis. Our aim was to implement a time-effective and reproducible protocol to isolate high quality RNA from specific pancreatic cell subtypes, in normal and inflammatory conditions. We used two genetically engineered mouse models (GEMM), Ela-CreER/YFP and Sox9-CreER/YFP, to isolate acinar and ductal cells, respectively...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29532564/etv5-regulates-ductal-morphogenesis-with-sox9-and-is-critical-for-regeneration-from-pancreatitis
#20
Koushik K Das, Steffen Heeg, Jason R Pitarresi, Maximilian Reichert, Basil Bakir, Shigetsugu Takano, Janel L Kopp, Anja Wahl-Feuerstein, Philip Hicks, Maike Sander, Anil K Rustgi
BACKGROUND: The plasticity of pancreatic acinar cells to undergo acinar to ductal metaplasia (ADM) has been demonstrated to contribute to the regeneration of the pancreas in response to injury. Sox9 is critical for ductal cell fate and important in the formation of ADM, most likely in concert with a complex hierarchy of, as yet, not fully elucidated transcription factors. RESULTS: Utilizing a mouse model of acute pancreatitis and three dimensional organoid culture of primary pancreatic ductal cells, we herein characterize the Ets-transcription factor Etv5 as a pivotal regulator of ductal cell identity and ADM that acts upstream of Sox9 and is essential for Sox9 expression in ADM...
March 13, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
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