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https://www.readbyqxmd.com/read/29161539/home-is-where-the-future-is-the-brightfocus-foundation-consensus-panel-on-dementia-care
#1
Quincy M Samus, Constantine G Lyketsos, Betty Smith Black, Diane Bovenkamp, Michael Buckley, Christopher Callahan, Karen Davis, Laura N Gitlin, Nancy Hodgson, Deirdre Johnston, Helen C Kales, Michele Karel, John Jay Kenney, Shari M Ling, Maï Panchal, Melissa Reuland, Amber Willink
INTRODUCTION: A national consensus panel was convened to develop recommendations on future directions for home-based dementia care (HBDC). METHODS: The panel summarized advantages and challenges of shifting to HBDC as the nexus of care and developed consensus-based recommendations. RESULTS: The panel developed five core recommendations: (1) HBDC should be considered the nexus of new dementia models, from diagnosis to end of life in dementia; (2) new payment models are needed to support HBDC and reward integration of care; (3) a diverse new workforce that spans the care continuum should be prepared urgently; (4) new technologies to promote communication, monitoring/safety, and symptoms management must be tested, integrated, and deployed; and (5) targeted dissemination efforts for HBDC must be employed...
November 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29161399/global-lessons-developing-military-trauma-care-and-lessons-for-civilian-practice
#2
T Woolley, J A Round, M Ingram
The wars in Iraq and Afghanistan have helped to shape the modern Defence Medical Services. Many lessons were learnt including the need for rapid haemorrhage control, senior decision-making and the evolution of deployed transfusion support. These changes were implemented simultaneously with a coherent, end-to-end medical plan from point of wounding through to rehabilitation. Implementation of the medical plan is harmonious with the NHS trauma pathway, and is key to ensuring effective delivery. Military anaesthetists have a long pre-deployment training pathway starting with a Certificate of Completion of Training (CCT) in anaesthesia and/or critical care, and with an emphasis on military skills related to their specific role...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161394/managing-anaesthetic-provision-for-global-disasters
#3
R M Craven
The numbers of people affected by large-scale disasters has increased in recent decades. Disasters produce a huge burden of surgical morbidity at a time when the affected country is least able to respond. For this reason an international disaster response is often required. For many years this disaster response was not coordinated. The response consisted of what was available not what was needed and standards of care varied widely producing a healthcare lottery for the affected population. In recent years the World Health organisation has initiated the Emergency Medical Team programme to coordinate the response to disasters and set minimum standards for responding teams...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161322/altered-juvenile-fish-communities-associated-with-invasive-halophila-stipulacea-seagrass-habitats-in-the-u-s-virgin-islands
#4
Lauren K Olinger, Sarah L Heidmann, Allie N Durdall, Colin Howe, Tanya Ramseyer, Sara G Thomas, Danielle N Lasseigne, Elizabeth J Brown, John S Cassell, Michele M Donihe, Mareike D Duffing Romero, Mara A Duke, Damon Green, Paul Hillbrand, Kristin R Wilson Grimes, Richard S Nemeth, Tyler B Smith, Marilyn Brandt
Caribbean seagrass habitats provide food and protection for reef-associated juvenile fish. The invasive seagrass Halophila stipulacea is rapidly altering these seascapes. Since its arrival in the Caribbean in 2002, H. stipulacea has colonized and displaced native seagrasses, but the function of this invasive seagrass as a juvenile fish habitat remains unknown. To compare diversity, community structure, and abundance of juvenile fish between H. stipulacea and native seagrass beds, fish traps were deployed in four nearshore bays around St...
2017: PloS One
https://www.readbyqxmd.com/read/29161308/effects-of-tones-associated-with-drilling-activities-on-bowhead-whale-calling-rates
#5
Susanna B Blackwell, Christopher S Nations, Aaron M Thode, Mandy E Kauffman, Alexander S Conrad, Robert G Norman, Katherine H Kim
During summer 2012 Shell performed exploratory drilling at Sivulliq, a lease holding located in the autumn migration corridor of bowhead whales (Balaena mysticetus), northwest of Camden Bay in the Beaufort Sea. The drilling operation involved a number of vessels performing various activities, such as towing the drill rig, anchor handling, and drilling. Acoustic data were collected with six arrays of directional recorders (DASARs) deployed on the seafloor over ~7 weeks in Aug-Oct. Whale calls produced within 2 km of each DASAR were identified and localized using triangulation...
2017: PloS One
https://www.readbyqxmd.com/read/29161165/alcohol-misuse-in-reserve-soldiers-and-their-partners-cross-spouse-effects-of-deployment-and-combat-exposure
#6
Bonnie M Vest, Sarah Cercone Heavey, D Lynn Homish, Gregory G Homish
BACKGROUND: Military deployment and combat are associated with worse outcomes, including alcohol misuse. Less is known about how these experiences affect soldiers' spouses. OBJECTIVE: The study objective was to explore relationships between deployment, combat exposure, and alcohol misuse; especially cross-spouse effects (effect of one partner's experiences/behavior on the other partner), which has been under-examined in military samples. METHODS: U...
November 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29160861/a-lightweight-anonymous-authentication-protocol-with-perfect-forward-secrecy-for-wireless-sensor-networks
#7
Ling Xiong, Daiyuan Peng, Tu Peng, Hongbin Liang, Zhicai Liu
Due to their frequent use in unattended and hostile deployment environments, the security in wireless sensor networks (WSNs) has attracted much interest in the past two decades. However, it remains a challenge to design a lightweight authentication protocol for WSNs because the designers are confronted with a series of desirable security requirements, e.g., user anonymity, perfect forward secrecy, resistance to de-synchronization attack. Recently, the authors presented two authentication schemes that attempt to provide user anonymity and to resist various known attacks...
November 21, 2017: Sensors
https://www.readbyqxmd.com/read/29160768/diverse-modes-of-synaptic-signaling-regulation-and-plasticity-distinguish-classes-of-c-elegans-glutamatergic-neurons
#8
Donovan Ventimiglia, Cornelia I Bargmann
Synaptic vesicle release properties vary between neuronal cell types, but in most cases the molecular basis of this heterogeneity is unknown. Here, we compare in vivo synaptic properties of two neuronal classes in the C. elegans central nervous system, using VGLUT-pHluorin to monitor synaptic vesicle exocytosis and retrieval in intact animals. We show that the glutamatergic sensory neurons AWC(ON) and ASH have distinct synaptic dynamics associated with tonic and phasic synaptic properties, respectively. Exocytosis in ASH and AWC(ON) is differentially affected by SNARE-complex regulators that are present in both neurons: phasic ASH release is strongly dependent on UNC-13, whereas tonic AWC(ON) release relies upon UNC-18 and on the protein kinase C homolog PKC-1...
November 21, 2017: ELife
https://www.readbyqxmd.com/read/29160560/a-functional-near-infrared-spectroscopy-study-of-trauma-related-auditory-and-olfactory-cues-posttraumatic-stress-disorder-or-combat-experience
#9
Michael A Gramlich, Sandra M Neer, Deborah C Beidel, Corey J Bohil, Clint A Bowers
The prevalence of posttraumatic stress disorder (PTSD) among U.S. veterans deployed to Iraq or Afghanistan necessitates the need for comprehensive assessment and treatment strategies. This study investigated the utility of a combat-related PTSD symptom provocation paradigm to elicit unique neurological responses across three groups: combat veterans with PTSD, combat veterans without PTSD, and nonmilitary participants without PTSD. Using functional near-infrared spectroscopy (fNIRS) the results indicated that combat veterans with PTSD demonstrated significant activation to a trauma-related sound compared with nonmilitary personnel, channel 14: d = 1...
November 21, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29159559/cerberus-an-access-control-scheme-for-enforcing-least-privilege-in-patient-cohort-study-platforms-a-comprehensive-access-control-scheme-applied-to-the-genida-project-study-of-genetic-forms-of-intellectual-disabilities-and-autism-spectrum-disorders
#10
Pierre Parrend, Timothée Mazzucotelli, Florent Colin, Pierre Collet, Jean-Louis Mandel
Cohort Study Platforms (CSP) are emerging as a key tool for collecting patient information, providing new research data, and supporting family and patient associations. However they pose new ethics and regulatory challenges since they cross the gap between patients and medical practitioners. One of the critical issues for CSP is to enforce a strict control on access privileges whilst allowing the users to take advantage of the breadth of the available data. We propose Cerberus, a new access control scheme spanning the whole life-cycle of access right management: design, implementation, deployment and maintenance, operations...
November 16, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29159155/how-to-escape-stentriever-wedging-in-an-open-cell-carotid-stent-during-mechanical-thrombectomy-for-tandem-cervical-internal-carotid-artery-and-middle-cerebral-artery-occlusion
#11
Hae Won Rho, Won Ki Yoon, Jang Hun Kim, Jong Hyun Kim, Taek Hyun Kwon
We present 2 cases of complicated mechanical thrombectomy involving tandem cervical internal carotid artery and middle cerebral artery occlusion using the Solitaire FR stent and simultaneous carotid stent angioplasty. During the procedures, the Solitaire stents containing the thrombus were wedged into the open-cell carotid stents, which were already deployed for proximal flow restoration. We describe the methods used to avoid and overcome such complications.
September 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/29158838/crispr-genome-engineering-for-human-pluripotent-stem-cell-research
#12
REVIEW
Somali Chaterji, Eun Hyun Ahn, Deok-Ho Kim
The emergence of targeted and efficient genome editing technologies, such as repurposed bacterial programmable nucleases (e.g., CRISPR-Cas systems), has abetted the development of cell engineering approaches. Lessons learned from the development of RNA-interference (RNA-i) therapies can spur the translation of genome editing, such as those enabling the translation of human pluripotent stem cell engineering. In this review, we discuss the opportunities and the challenges of repurposing bacterial nucleases for genome editing, while appreciating their roles, primarily at the epigenomic granularity...
2017: Theranostics
https://www.readbyqxmd.com/read/29158529/accurate-thermal-conductivities-from-optimally-short-molecular-dynamics-simulations
#13
Loris Ercole, Aris Marcolongo, Stefano Baroni
The evaluation of transport coefficients in extended systems, such as thermal conductivity or shear viscosity, is known to require impractically long simulations, thus calling for a paradigm shift that would allow to deploy state-of-the-art quantum simulation methods. We introduce a new method to compute these coefficients from optimally short molecular dynamics simulations, based on the Green-Kubo theory of linear response and the cepstral analysis of time series. Information from the full sample power spectrum of the relevant current for a single and relatively short trajectory is leveraged to evaluate and optimally reduce the noise affecting its zero-frequency value, whose expectation is proportional to the corresponding conductivity...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158414/molecular-basis-of-selective-resistance-of-the-bumblebee-binav1-sodium-channel-to-tau-fluvalinate
#14
Shaoying Wu, Yoshiko Nomura, Yuzhe Du, Boris S Zhorov, Ke Dong
Insecticides are widely used to control pests in agriculture and insect vectors that transmit human diseases. However, these chemicals can have a negative effect on nontarget, beneficial organisms including bees. Discovery and deployment of selective insecticides is a major mission of modern toxicology and pest management. Pyrethroids exert their toxic action by acting on insect voltage-gated sodium channels. Honeybees and bumblebees are highly sensitive to most pyrethroids, but are resistant to a particular pyrethroid, tau-fluvalinate (τ-FVL)...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29157681/endovascular-treatment-of-the-ascending-aorta-using-a-combined-transapical-and-transfemoral-approach
#15
Philippe Grieshaber, Nadine Nink, Peter Roth, Meshal Elzien, Andreas Böning, Ahmed Koshty
In high-risk patients with diseases of the ascending aorta, endovascular repair might be a therapeutic alternative to surgical repair. We developed a combined access route with transapical and transfemoral externalization of the wire and report the operative technique as well as our initial experience of six patients treated with this method. Improved wire control resulted in precise deployment of endovascular prostheses, respecting the integrity of the coronary ostia and the supra-aortic vessels. Procedural success was 100%, and follow-up until 32 months postoperatively showed no need for reintervention or mortality...
November 17, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29157418/perceptual-episodes-temporal-attention-and-the-role-of-cognitive-control-lessons-from-the-attentional-blink
#16
Guy Snir, Yaffa Yeshurun
The ability to identify a target is usually hindered if it appears shortly after another target. This simple and somewhat intuitive observation is qualified by a multitude of unexpected findings and conflicting theories that originate from the attentional blink paradigm. In this review, the major results, implications, and outstanding questions that stem from the paradigm are presented and discussed. The extant literature suggests that when the temporal domain is densely stacked with numerous stimuli, the entities that underlie attentional selection and cognitive control are brief perceptual episodes...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29157240/automatic-diagnosis-of-imbalanced-ophthalmic-images-using-a-cost-sensitive-deep-convolutional-neural-network
#17
Jiewei Jiang, Xiyang Liu, Kai Zhang, Erping Long, Liming Wang, Wangting Li, Lin Liu, Shuai Wang, Mingmin Zhu, Jiangtao Cui, Zhenzhen Liu, Zhuoling Lin, Xiaoyan Li, Jingjing Chen, Qianzhong Cao, Jing Li, Xiaohang Wu, Dongni Wang, Jinghui Wang, Haotian Lin
BACKGROUND: Ocular images play an essential role in ophthalmological diagnoses. Having an imbalanced dataset is an inevitable issue in automated ocular diseases diagnosis; the scarcity of positive samples always tends to result in the misdiagnosis of severe patients during the classification task. Exploring an effective computer-aided diagnostic method to deal with imbalanced ophthalmological dataset is crucial. METHODS: In this paper, we develop an effective cost-sensitive deep residual convolutional neural network (CS-ResCNN) classifier to diagnose ophthalmic diseases using retro-illumination images...
November 21, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29156639/constructing-an-indoor-floor-plan-using-crowdsourcing-based-on-magnetic-fingerprinting
#18
Haiyong Luo, Fang Zhao, Mengling Jiang, Hao Ma, Yuexia Zhang
A large number of indoor positioning systems have recently been developed to cater for various location-based services. Indoor maps are a prerequisite of such indoor positioning systems; however, indoor maps are currently non-existent for most indoor environments. Construction of an indoor map by external experts excludes quick deployment and prevents widespread utilization of indoor localization systems. Here, we propose an algorithm for the automatic construction of an indoor floor plan, together with a magnetic fingerprint map of unmapped buildings using crowdsourced smartphone data...
November 20, 2017: Sensors
https://www.readbyqxmd.com/read/29156263/application-of-biochar-from-food-and-wood-waste-as-green-admixture-for-cement-mortar
#19
Souradeep Gupta, Harn Wei Kua, Hui Jun Koh
Landfilling of food waste due to its low recycling rate is raising serious concerns because of associated soil and water contamination, and emission of methane and other greenhouse gases during the degradation process. This paper explores feasibility of using biochar derived from mixed food waste (FWBC), rice waste (RWBC) and wood waste (mixed wood saw dust, MWBC) as carbon sequestering additive in mortar. RWBC is prepared from boiled plain rice, while FWBC is prepared from combination of rice, meat, and vegetables in fixed proportion...
November 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29155940/stented-balloon-fenestration-before-entry-repair-using-the-frozen-elephant-trunk-technique-for-chronic-aortic-dissection
#20
Naomichi Uchida, Yoshitaka Yamane, Tomokuni Furukawa
Endovascular fenestration on the abdominal aorta is effective for preventing visceral malperfusion in aortic dissection. We report a case of stented balloon fenestration before residual entry repair using the frozen elephant trunk technique for chronic aneurysmal dissection after ascending aortic replacement for DeBakey I aortic dissection. We recognized poor communication between the true lumen and false lumen in the abdominal aorta, and visceral perfusion depended almost entirely on the proximal large entry...
October 9, 2017: Interactive Cardiovascular and Thoracic Surgery
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