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Phytoestrogen in soy

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https://www.readbyqxmd.com/read/28674520/endocrine-disruption-of-vasopressin-systems-and-related-behaviors
#1
REVIEW
Heather B Patisaul
Endocrine disrupting chemicals (EDCs) are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a myriad of species reveals that the nonapeptide hormones vasopressin (AVP) and oxytocin (OT) may also be EDC targets. EDCs shown to alter pathways and behaviors coordinated by AVP and/or OT include the plastics component bisphenol A (BPA), the soy phytoestrogen genistein (GEN), and various flame retardants...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28637300/commercial-rodent-diets-differentially-regulate-autoimmune-glomerulonephritis-epigenetics-and-microbiota-in-mrl-lpr-mice
#2
Michael R Edwards, Rujuan Dai, Bettina Heid, Thomas E Cecere, Deena Khan, Qinghui Mu, Catharine Cowan, Xin M Luo, S Ansar Ahmed
The course and severity of lupus in spontaneous murine lupus models varies among laboratories, which may be due to variations in diet, housing and/or local environmental conditions. In this study, we investigated the influence of common rodent diets while keeping other factors constant. Female lupus-prone MRL/lpr mice were subjected to the same housing conditions and given one of the three diets: Teklad 7013 containing isoflavone rich soy and alfalfa, Harlan 2018 isoflavone rich soy-based diet, or ResearchDiets Inc...
June 15, 2017: International Immunology
https://www.readbyqxmd.com/read/28585232/in-vitro-in-silico-based-analysis-of-the-dose-dependent-in-vivo-estrogenicity-of-the-soy-phytoestrogen-genistein-in-humans
#3
Rungnapa Boonpawa, Albertus Spenkelink, Ans Punt, Ivonne M C M Rietjens
BACKGROUND AND PURPOSE: In vivo estrogenicity of genistein and its glycoside genistin is still under debate. The present study aimed to develop a physiologically based kinetic (PBK) model that provides insight in dose-dependent plasma concentrations of genistein aglycone and its metabolites and enables prediction of in vivo estrogenic effective dose levels of genistein and genistin in humans. EXPERIMENTAL APPROACH: A PBK model for genistein and genistin in humans was developed based on in vitro metabolic parameters...
June 5, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28546801/the-safety-and-tolerance-of-phytotherapies-in-menopausal-medicine-a-review-of-the-literature
#4
REVIEW
Piotr Czuczwar, Tomasz Paszkowski, Marek Lisiecki, Sławomir Woźniak, Anna Stępniak
Phytoestrogens are polyphenol, non-steroidal substances of plant origin, resembling 17β-estradiol in structure. These substances can act as either agonists or antagonists of oestrogen receptors α and β. Phytoestrogens are widely used to alleviate menopausal symptoms, such as hot flushes and night sweats. Most of the currently available products of plant origin registered to soften climacteric symptoms consist of extracts obtained from soy, red clover, or black cohosh. Non-hormonal phytotherapy is a new alternative for patients suffering from menopausal symptoms...
March 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28508697/collagen-concentration-on-the-facial-skin-of-postmenopausal-women-after-topical-treatment-with-estradiol-and-genistein-a-randomized-double-blind-controlled-trial
#5
Lidia Aragão Silva, Adriana Aparecida Ferraz Carbonel, Andréa Regina Barbosa de Moraes, Ricardo S Simões, Gisela Rodrigues da Silva Sasso, Lívia Goes, Winnie Nunes, Manuel Jesus Simões, Marisa Teresinha Patriarca
OBJECTIVE: The objective of this study is to compare the effects of topical estrogen and genistein (a soy isoflavone) on the facial skin collagen of postmenopausal women not undergoing systemic hormonal therapy. METHODS: This is a prospective, double blind, randomized, controlled clinical trial. Volunteer women (N = 30) 45-55 year old from the Endocrine Gynecology sector of the Gynecology Department of the Federal University of São Paulo (UNIFESP). The Ethical Committee of the Federal University of São Paulo approved the study (report no...
May 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28412308/genistein-prevention-of-hyperglycemia-and-improvement-of-glucose-tolerance-in-adult-non-obese-diabetic-mice-are-associated-with-alterations-of-gut-microbiome-and-immune-homeostasis
#6
Guannan Huang, Joella Xu, Daniel E Lefever, Travis C Glenn, Tamas Nagy, Tai L Guo
Although studies have linked soy phytoestrogen 4,7,4-trihydroxyisoflavone genistein (GEN) to reduced type 1 diabetes (T1D) risk, the mechanism of dietary GEN on T1D remains unknown. In our studies, adult non-obese diabetic (NOD) mouse model was employed to investigate the effects of GEN exposure on blood glucose level (BGL), glucose tolerance, gut microbiome, and immune responses. Adult male and female NOD mice were fed with either soy-based or casein-based diet, and received GEN at 20mg/kg body weight by gavage daily...
April 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28351156/long-term-exercise-training-and-soy-isoflavones-to-improve-quality-of-life-and-climacteric-symptoms
#7
A Fontvieille, I J Dionne, E Riesco
OBJECTIVE: To verify the efficacy of phytoestrogen supplementation combined with aerobic and resistance training on the improvement of climacteric symptoms and health-related quality of life (HRQoL) in postmenopausal women. METHODS: From a pool of women who had participated in a 1-year intervention study and were randomly assigned to either exercise + phytoestrogen (EX + PHY) or exercise + placebo (EX + PL), a total of 31 healthy but overweight women (mean age 59...
March 29, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28264445/equol-a-dietary-daidzein-gut-metabolite-attenuates-microglial-activation-and-potentiates-neuroprotection-in-vitro
#8
Lalita Subedi, Eunhee Ji, Dongyun Shin, Jongsik Jin, Joo Hong Yeo, Sun Yeou Kim
Estrogen deficiency has been well characterized in inflammatory disorders including neuroinflammation. Daidzein, a dietary alternative phytoestrogen found in soy (Glycine max) as primary isoflavones, possess anti-inflammatory activity, but the effect of its active metabolite Equol (7-hydroxy-3-(4'-hydroxyphenyl)-chroman) has not been well established. In this study, we investigated the anti-neuroinflammatory and neuroprotective effect of Equol in vitro. To evaluate the potential effects of Equol, three major types of central nervous system (CNS) cells, including microglia (BV-2), astrocytes (C6), and neurons (N2a), were used...
February 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28263368/dietary-isoflavone-intake-and-all-cause-mortality-in-breast-cancer-survivors-the-breast-cancer-family-registry
#9
Fang Fang Zhang, Danielle E Haslam, Mary Beth Terry, Julia A Knight, Irene L Andrulis, Mary B Daly, Saundra S Buys, Esther M John
BACKGROUND: Soy foods possess both antiestrogenic and estrogen-like properties. It remains controversial whether women diagnosed with breast cancer should be advised to eat more or less soy foods, especially for those who receive hormone therapies as part of cancer treatment. METHODS: The association of dietary intake of isoflavone, the major phytoestrogen in soy, with all-cause mortality was examined in 6235 women with breast cancer enrolled in the Breast Cancer Family Registry...
June 1, 2017: Cancer
https://www.readbyqxmd.com/read/28248181/phytoestrogens-in-soy-infant-formula-association-with-dna-methylation-in-girls-has-unknown-implications
#10
Nate Seltenrich
No abstract text is available yet for this article.
March 1, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28183304/genistein-treatment-improves-fracture-resistance-in-obese-diabetic-mice
#11
Britton Odle, Nathan Dennison, Layla Al-Nakkash, Tom L Broderick, Jeffrey H Plochocki
BACKGROUND: Obese, type two diabetics are at an increased risk for fracturing their limb bones in comparison to the general population. Phytoestrogens like as the soy isoflavone genistein have been shown to protect against bone loss. In this study, we tested the effects of genistein treatment on femurs of ob/ob mice, a model for obesity and type two diabetes mellitus. METHODS: Twenty six-week-old female mice were divided into obese (ob/ob) control, obese genistein-treated, lean (ob/+) control, and lean genistein-treated groups (n = 5 each)...
January 9, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28125641/synergistic-action-of-genistein-and-calcitriol-in-immature-osteosarcoma-mg-63-cells-by-sgpl1-up-regulation
#12
Nadja Engel, Anna Adamus, Nicolas Schauer, Juliane Kühn, Barbara Nebe, Guido Seitz, Karin Kraft
BACKGROUND: Phytoestrogens such as genistein, the most prominent isoflavone from soy, show concentration-dependent anti-estrogenic or estrogenic effects. High genistein concentrations (>10 μM) also promote proliferation of bone cancer cells in vitro. On the other hand, the most active component of the vitamin D family, calcitriol, has been shown to be tumor protective in vitro and in vivo. The purpose of this study was to examine a putative synergism of genistein and calcitriol in two osteosarcoma cell lines MG-63 (early osteoblast), Saos-2 (mature osteoblast) and primary osteoblasts...
2017: PloS One
https://www.readbyqxmd.com/read/28096960/estrogen-agonist-genistein-differentially-influences-the-cognitive-and-motor-disorders-in-an-ovariectomized-animal-model-of-parkinsonism
#13
Elaheh Arbabi, Gholamali Hamidi, Sayyed Alireza Talaei, Mahmoud Salami
OBJECTIVES: Parkinson's disease (PD) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. Evidence indicates that PD occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. It is reported that soy genistein, an estrogen agonist phytoestrogen, display neuroprotective effects against neuronal death. In this study we evaluated the effect of genistein in animal models of Parkinsonism (P) and Parkinsonism + ovariectomized (OP)...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28063855/low-dietary-soy-isoflavonoids-increase-hippocampal-spine-synapse-density-in-ovariectomized-rats
#14
Neil J MacLusky, Gladis Thomas, Csaba Leranth
High dietary intake of plant estrogens (phytoestrogens) can affect brain structure and function. The effects of phytoestrogen intake within the range of normal animal and human dietary consumption, however, remain uncertain. The aim of the present study was to determine the effects of the isoflavonoids present in a standard low phytoestrogen laboratory rat chow on spine synapse density in the stratum radiatum of area CA1 of the hippocampus. Weanling rats (22days old) were fed either standard chow (Teklad 2018), a nutritionally comparable diet without soy (Teklad 2016) or a custom diet containing Teklad 2016 supplemented with the principal soy isoflavonoids, daidzein and genistein, for 40days...
February 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28054115/-risk-and-benefit-of-nutritional-supplements-for-the-treatment-of-postmenopausal-complaints
#15
Patrick Diel, Anne Kurrat, Christina Oden, Lars Hanke
Menopause is for many females associated with an occurrence of a variety of health complaints and a decrease in quality in life. Hot flashes, sleep disturbances and a variety of other symptoms result in a strong psychological strain. Hormone replacement therapy for treatment of climacteric complaints is discussed controversially regarding associated side effects. This is a major reason to propose treatment with plant derived extracts and compounds as an alternative. Such compounds are available either as drugs but mostly as nutritional supplements...
January 4, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28031375/urinary-phytoestrogen-concentrations-are-not-associated-with-incident-endometriosis-in-premenopausal-women
#16
Sunni L Mumford, Jennifer Weck, Kurunthachalam Kannan, Germaine M Buck Louis
BACKGROUND: Phytoestrogens have been associated with subtle hormonal changes, but their effects on endometriosis are largely unknown. OBJECTIVE: We assessed the association between urinary concentrations of phytoestrogens and incident endometriosis. METHODS: We included an operative sample of 495 premenopausal women aged 18-44 y undergoing laparoscopies and laparotomies at 14 clinical sites between 2007 and 2009 and a general population sample of 131 women from the same geographic area who were matched on age and menstruation status...
February 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28017703/prepubertal-subchronic-exposure-to-soy-milk-and-glyphosate-leads-to-endocrine-disruption
#17
Jessica Nardi, Patricia Bonamigo Moras, Carina Koeppe, Eliane Dallegrave, Mirna Bainy Leal, Luciana Grazziotin Rossato-Grando
Lactose intolerance is characterized by low or inexistent levels of lactase, and the main treatment consists of dietary changes, especially replacing dairy milk by soy milk. Soy contains phytoestrogens, substances with known estrogenic activity, besides, glyphosate-based herbicides are extensively used in soy crops, being frequently a residue in soy beans, bringing to a concern regarding the consumption of soy-based products, especially for children in breastfeeding period with lactose intolerance. This study evaluated the pubertal toxicity of a soy milk rich feeding (supplemented or not with glyphosate, doses of 50 and 100 mg/kg) during prepubertal period in male rats...
February 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27984170/autism-genes-are-selectively-targeted-by-environmental-pollutants-including-pesticides-heavy-metals-bisphenol-a-phthalates-and-many-others-in-food-cosmetics-or-household-products
#18
REVIEW
C J Carter, R A Blizard
The increasing incidence of autism suggests a major environmental influence. Epidemiology has implicated many candidates and genetics many susceptibility genes. Gene/environment interactions in autism were analysed using 206 autism susceptibility genes (ASG's) from the Autworks database to interrogate ∼1 million chemical/gene interactions in the comparative toxicogenomics database. Any bias towards ASG's was statistically determined for each chemical. Many suspect compounds identified in epidemiology, including tetrachlorodibenzodioxin, pesticides, particulate matter, benzo(a)pyrene, heavy metals, valproate, acetaminophen, SSRI's, cocaine, bisphenol A, phthalates, polyhalogenated biphenyls, flame retardants, diesel constituents, terbutaline and oxytocin, inter alia showed a significant degree of bias towards ASG's, as did relevant endogenous agents (retinoids, sex steroids, thyroxine, melatonin, folate, dopamine, serotonin)...
October 27, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27927075/soy-isoflavones-exert-beneficial-effects-on-letrozole-induced-rat-polycystic-ovary-syndrome-pcos-model-through-anti-androgenic-mechanism
#19
Ravi Kumar Rajan, Siva Selva Kumar M, Bhaskar Balaji
CONTEXT: Soy is the main source of phytoestrogens, which has long been used as traditional food. One major subtype of phytoestrogens includes isoflavones and they are scientifically validated for their beneficial actions on many hormone-dependent conditions. OBJECTIVE: The present study examines the effect of soy isoflavones on letrozole-induced polycystic ovary syndrome (PCOS) rat model. MATERIALS AND METHODS: PCOS was induced in Sprague-Dawley rats with of 1 mg/kg letrozole, p...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27913286/cytotoxic-activity-of-soy-phytoestrogen-coumestrol-against-human-breast-cancer-mcf-7%C3%A2-cells-insights-into-the-molecular-mechanism
#20
Atif Zafar, Swarnendra Singh, Imrana Naseem
Coumestrol is a phytoestrogen present in soybean products and recognized as potential cancer therapeutic agent against breast cancer. However, the clear molecular mechanism of anticancer-activity of coumestrol in breast carcinoma has not been reported. It is well established that copper levels are elevated in different malignancies. Therefore, the objective of this study was to investigate the copper-dependent cytotoxic action of coumestrol in human breast cancer MCF-7 cells. Results showed that coumestrol inhibited proliferation and induced apoptosis in MCF-7 cells, which was prevented by copper chelator neocuproine and ROS scavengers...
January 2017: Food and Chemical Toxicology
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