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Phytoestrogen in soy

Mark Messina
Soyfoods have long been recognized as sources of high-quality protein and healthful fat, but over the past 25 years these foods have been rigorously investigated for their role in chronic disease prevention and treatment. There is evidence, for example, that they reduce risk of coronary heart disease and breast and prostate cancer. In addition, soy alleviates hot flashes and may favorably affect renal function, alleviate depressive symptoms and improve skin health. Much of the focus on soyfoods is because they are uniquely-rich sources of isoflavones...
November 24, 2016: Nutrients
Young Jin Jang, Hyo Jeong Son, Jiyun Ahn, Chang Hwa Jung, Taeyoul Ha
Coumestrol is a natural phytochemical present in plants such as red clover and soy, and has been reported to stimulate the estrogen receptor as a major phytoestrogen. While the molecular mechanisms responsible for the anti-adipogenic effects of phytoestrogens such as genistein and daidzein have been previously investigated, the effects of coumestrol on adipogenesis remain to be elucidated. We observed that coumestrol dose-dependently attenuates MDI (mixture of 3-isobutyl-1-methylxanthine, dexamethasone, and insulin)-induced lipid accumulation, consistent with an earlier study, while significantly inhibiting MDI-induced adipogenesis in the first 48 hours of differentiation, a critical time window for anti-adipogenic effects...
November 21, 2016: Food & Function
Touqeer Ahmed, Sana Javed, Ameema Tariq, Barbara Budzy, Grazia D Onofrio, Maria Daglia, Seyed Fazel Nabavi, Seyed Mohammad Nabavi
Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound- thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which has been reported to affect various neurobiological regulatory mechanisms such as behavior, cognition, growth, development and reproduction. These effects are mainly elicited through the interaction of daidzein with different signaling molecules and receptors, thereby offering neuroprotection...
November 1, 2016: Current Medicinal Chemistry
Catherine Bennetau-Pelissero
PURPOSE OF REVIEW: The estrogenic effects of genistein, as reconfirmed by the American National Toxicology Program (USA-NTP), have led to several new clinical studies being undertaken. Here, we highlight the most relevant recent data, reporting either beneficial or adverse effects. RECENT FINDINGS: Phytoestrogens are natural molecules from edible plants exhibiting estrogenic activities. Post-USA-NTP studies investigated both human and animal reproductive and other physiological issues...
November 2016: Current Opinion in Clinical Nutrition and Metabolic Care
Katharina Vejdovszky, Verena Schmidt, Benedikt Warth, Doris Marko
SCOPE: The isoflavone genistein, present in soy-based food and dietary supplements, is known for its estrogenic potential. In addition to phytoestrogens, food may also contain mycotoxins with estrogenic properties like zearalenone or alternariol, raising the question on potential combinatory effects of these xenoestrogens. METHODS AND RESULTS: Combinatory estrogenic effects of genistein with zeralenone or alternariol were studied in the human endometrial adenocarcinoma cell line Ishikawa as expression of alkaline phosphatase (AlP) activity...
October 14, 2016: Molecular Nutrition & Food Research
Sankar Panneerselvam, Rajaa Muthu Packirisamy, Zachariah Bobby, Sajini Elizabeth Jacob, Magadi Gopalakrishna Sridhar
Obesity emerged as the major risk factor for metabolic syndrome. Postmenopausal women are more prone to develop obesity than premenopausal women. The absence of safe and effective conventional treatments for postmenopausal obesity has changed the focus to natural products as alternative remedy. We investigated the molecular basis of the effect of soy isoflavones (SIFs) on hypertriglyceridemia and hepatic steatosis in an animal model of postmenopausal obesity. Ovariectomized (OVX) and sham-operated Wistar rats were fed with high-fat diet (HFD) and normal diet for 8 weeks with and without SIF extract (150mg/kg body weight/day)...
September 8, 2016: Journal of Nutritional Biochemistry
F Abdi, Z Alimoradi, P Haqi, F Mahdizad
INTRODUCTION: Menopause is associated with increased bone resorption and decreased bone mineral density (BMD). Phytoestrogens are believed to prevent bone loss. This study reviewed relevant randomized, controlled trials to determine the effects of phytoestrogens on BMD in postmenopausal women. METHODS: In order to perform this systematic review, PubMed, Science Direct, Scopus, Cochrane Library, ISI Web of Knowledge, and ProQuest databases were searched for articles published during 2005-2016...
October 6, 2016: Climacteric: the Journal of the International Menopause Society
Qingxia Zhao, Ming Zhao, Amanda B Parris, Ying Xing, Xiaohe Yang
Genistein is a soy isoflavone with phytoestrogen and tyrosine kinase inhibitory properties. High intake of soy/genistein has been associated with reduced breast cancer risk. Despite the advances in genistein-mediated antitumor studies, the underlying mechanisms remain unclear. In the present study, we investigated genistein-induced regulation of the cancerous inhibitor of protein phosphatase 2A (CIP2A), a novel oncogene frequently overexpressed in breast cancer, and its functional impact on genistein-induced growth inhibition and apoptosis...
September 2016: International Journal of Oncology
Sophia Harlid, Margaret Adgent, Wendy N Jefferson, Vijayalakshmi Panduri, David M Umbach, Zongli Xu, Virginia A Stallings, Carmen J Williams, Walter J Rogan, Jack A Taylor
BACKGROUND: Early life exposure to estrogenic compounds affects the development of the reproductive system in rodent models and humans. Soy products, which contain phytoestrogens such as genistein, are one source of exposure in infants fed soy formula and result in high serum concentrations. OBJECTIVES: To determine if soy exposure is associated with differential DNA methylation in vaginal cells from soy-fed infant girls. METHODS: Using the Illumina HumanMethylation450 BeadChip we evaluated epigenome-wide DNA methylation in vaginal cells from four soy-formula-fed and six cow-formula-fed girls from the Infant Feeding and Early Development (IFED) study...
August 19, 2016: Environmental Health Perspectives
Md Anisur Rahman Mazumder, Parichat Hongsprabhas
Genistein is a phytoestrogen with diverse biological activities. It is a potent antioxidant and antibrowning agent in in vivo and in vitro. Genistein acts as a preventative and therapeutic effects for cancers, postmenopausal syndrome, osteoporosis and cardiovascular diseases in animals and humans. Gensitein possesses cancer related enzyme-inhibitory effect and substantially inhibits skin carcinogenesis and cutaneous aging induced by ultraviolet (UV) light in mice and photodamage in humans. Two-stage skin carcinogenesis showed genistein exhibited a moderate inhibition of ornithine decarboxylase activity through blockage of DNA adducts formation...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Dalia O Saleh, Dina F Mansour
Cyclophosphamide (CP), the commonly used chemotherapeutic agent in cancer treatment, is proven to cause ovarian toxicity and infertility in women. In the present study, we investigated the protective effect of genistein (GEN), a phytoestrogen found in the soy protein, against CP-induced ovarian toxicity in rats. Forty female adult rats were allocated into five groups. A normal control group received the vehicle; another group was injected with a single acute intraperitoneal dose of CP (200mg/kg). Three other groups were pretreated with GEN (0...
October 15, 2016: European Journal of Pharmacology
Martin J J Ronis
Cytochromes P450 (CYPs) play an important role in metabolism and clearance of most clinically utilized drugs and other xenobiotics. They are important in metabolism of endogenous compounds including fatty acids, sterols, steroids and lipid-soluble vitamins. Dietary factors such as phytochemicals are capable of affecting CYP expression and activity, which may be important in diet-drug interactions and in the development of fatty liver disease, cardiovascular disease and cancer. One important diet-CYP interaction is with diets containing plant proteins, particularly soy protein...
August 2016: Drug Metabolism Reviews
B Hu, B Yu, D Tang, S Li, Y Wu
Daidzein, the most widely studied soy phytoestrogen, is not only a potential antiosteoporosis agent owing to its possible osteogenic activity, but also shows anticancer activity. However, the mechanisms through which daidzein affects osteoblast function have not been investigated thoroughly. Here, we show that daidzein stimulated cell proliferation and differentiation of osteoblasts, demonstrated by upregulation of XTT activity, enhancement of alkaline phosphatase (ALP) activity, and upregulation of osteoblast-specific marker genes, including Runt-related transcription factor 2 (Runx2) and Smad1, as well as upregulation of Runx2 and Smad1 protein expression...
2016: Genetics and Molecular Research: GMR
Kimani D Hicks, Alana W Sullivan, Jinyan Cao, Emily Sluzas, Meghan Rebuli, Heather B Patisaul
Concerns have been raised regarding the potential for endocrine disrupting compounds (EDCs) to alter brain development and behavior. Developmental exposure to bisphenol A (BPA), a ubiquitous EDC, has been linked to altered sociosexual and mood-related behaviors in various animal models and children but effects are inconsistent across laboratories and animal models creating confusion about potential risk in humans. Exposure to endocrine active diets, such as soy, which is rich in phytoestrogens, may contribute to this variability...
August 2016: Hormones and Behavior
Oscar H Franco, Rajiv Chowdhury, Jenna Troup, Trudy Voortman, Setor Kunutsor, Maryam Kavousi, Clare Oliver-Williams, Taulant Muka
IMPORTANCE: Between 40% and 50% of women in Western countries use complementary therapies to manage menopausal symptoms. OBJECTIVE: To determine the association of plant-based therapies with menopausal symptoms, including hot flashes, night sweats, and vaginal dryness. DATA SOURCES: The electronic databases Ovid MEDLINE, EMBASE, and Cochrane Central were systematically searched to identify eligible studies published before March 27, 2016. Reference lists of the included studies were searched for further identification of relevant studies...
June 21, 2016: JAMA: the Journal of the American Medical Association
Nam-Hee Kang, Hee-Chang Shin, Seunghyun Oh, Kyun-Hee Lee, Yoon-Bok Lee, Kyung-Chul Choi
Soy milk, which is produced from whole soybeans, contains a variety of biologically active components. Isoflavones are a class of soy-derived phytoestrogens with beneficial effects, among which genistein (GEN) has been previously indicated to reduce the risk of prostate cancer. The present study evaluated the effects of soy milk digestion extract (SMD) on the progression of prostate cancer via the estrogen receptor (ER)β in human LNCaP prostate cancer cells. To evaluate the effects of SMD (daizein, 1.988 mg/100g, glycitein, 23...
August 2016: Molecular Medicine Reports
M Zhang, K Wang, L Chen, B Yin, Y Song
This study uses current epidemiological data to evaluate whether phytoestrogen intake is associated with a reduced risk of prostate cancer. We performed a random-effect meta-analysis of published data retrieved from PubMed, Web of Science, ProQuest, and CNKI, which was supplemented by a manual search of relevant references. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Subgroup analysis and meta-regression were performed to explore the source of heterogeneity. Sensitivity analysis was evaluated to assess the stability of the results...
July 2016: Andrology
Alisa A Suen, Wendy N Jefferson, Charles E Wood, Elizabeth Padilla-Banks, Victoria L Bae-Jump, Carmen J Williams
UNLABELLED: The oncofetal protein sine oculis-related homeobox 1 (SIX1) is a developmental transcription factor associated with carcinogenesis in several human cancer types but has not been investigated in human endometrial cancer. In a model of hormonal carcinogenesis, mice neonatally exposed to the soy phytoestrogen genistein (GEN) or the synthetic estrogen diethylstilbestrol (DES) develop endometrial cancer as adults. Previously, we demonstrated that SIX1 becomes aberrantly expressed in the uteri of these mice...
September 2016: Molecular Cancer Research: MCR
Stefanie C Fleck, Mona I Churchwell, Daniel R Doerge, Justin G Teeguarden
UNLABELLED: Urine and serum biomonitoring was used to measure internal exposure to selected dietary estrogens in a cohort of 30 pregnant women. Exposure was measured over a period comprising one-half day in the field (6 h) and one day in a clinic (24 h). Biomonitoring of the dietary phytoestrogens genistein (GEN), daidzein (DDZ) and equol (EQ), as well as the mycoestrogen, zearalenone (ZEN) and its congeners, was conducted using UPLC-MS/MS. Biomonitoring revealed evidence of internal exposure to naturally occurring dietary estrogens during pregnancy...
September 2016: Food and Chemical Toxicology
Mehdi Khodamoradi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Khadije Esmaeilpour, Vahid Sheibani
The major objective of this study was to investigate the probable effects of genistein (one of the most important soy phytoestrogens-SPEs) on seizure-induced cognitive dysfunction, hippocampal early long-term potentiation (E-LTP) impairment and morphological damage to CA1 neurons in ovariectomized (OVX) rats. Three weeks after ovariectomy, cannulae were implanted over the left lateral ventricle. After a 7-day recovery period, animals were injected by genistein (0.5 or 5mg/kg) or vehicle during four consecutive days, each 24h...
September 5, 2016: European Journal of Pharmacology
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