keyword
MENU ▼
Read by QxMD icon Read
search

Myoinositol

keyword
https://www.readbyqxmd.com/read/28758940/non-targeted-metabolomics-analysis-of-golden-retriever-muscular-dystrophy-affected-muscles-reveals-alterations-in-arginine-and-proline-metabolism-and-elevations-in-glutamic-and-oleic-acid-in-vivo
#1
Muhammad Abdullah, Joe N Kornegay, Aubree Honcoop, Traci L Parry, Cynthia J Balog-Alvarez, Sara K O'Neal, James R Bain, Michael J Muehlbauer, Christopher B Newgard, Cam Patterson, Monte S Willis
BACKGROUND: Like Duchenne muscular dystrophy (DMD), the Golden Retriever Muscular Dystrophy (GRMD) dog model of DMD is characterized by muscle necrosis, progressive paralysis, and pseudohypertrophy in specific skeletal muscles. This severe GRMD phenotype includes moderate atrophy of the biceps femoris (BF) as compared to unaffected normal dogs, while the long digital extensor (LDE), which functions to flex the tibiotarsal joint and serves as a digital extensor, undergoes the most pronounced atrophy...
July 29, 2017: Metabolites
https://www.readbyqxmd.com/read/28721046/brain-metabolite-values-in-children-with-breath-holding-spells
#2
Mustafa Calik, Dilek Sen Dokumaci, Suna Sarikaya, Mahmut Demir, Ilhan Isik, Halil Kazanasmaz, Cemil Kaya, Hasan Kandemir
Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28708005/taurine-protects-lens-epithelial-cells-against-ultraviolet-b-induced-apoptosis
#3
Wu Dayang, Pang Dongbo
BACKGROUND: The massive uptake of compatible osmolytes is a self-protective response shared by lens exposed to hypertonic stress and ultraviolet stress. OBJECTIVE: This study aimed to investigate the protective effects of taurine against ultraviolet B-induced cytotoxicity in the lens epithelial cells. METHODS: Real-time PCR was used to measure osmolytes transport. Radioimmunoassay was used to measure osmolytes uptake. Cell counting kit-8 assays were used to measure cellular viability...
July 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28695670/mitochondrial-dysfunction-and-cerebral-metabolic-abnormalities-in-patients-with-mitochondrial-encephalomyopathy-subtypes-evidence-from-proton-mr-spectroscopy-and-muscle-biopsy
#4
Feng-Nan Niu, Hai-Lan Meng, Lei-Lei Chang, Hong-Yan Wu, Wei-Ping Li, Ren-Yuan Liu, Hui-Ting Wang, Bing Zhang, Yun Xu
AIMS: Accumulated evidence indicates that cerebral metabolic features, evaluated by proton magnetic resonance spectroscopy ((1) H-MRS), are sensitive to early mitochondrion dysfunction associated with mitochondrial encephalomyopathy (ME). The metabolite ratios of lactate (lac)/Cr, N-acetyl aspartate (NAA)/creatine (Cr), total choline (tCho)/Cr, and myoinositol (mI)/Cr are measured in the infarct-like lesions by (1) H-MRS and may reveal metabolic changes associated with ME. However, the application of this molecular imaging technique in the investigation of the pathology of ME subtypes is unknown...
August 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28686323/exploration-of-phytoconstituents-from-mussaenda-roxburghii-and-studies-of-their-antibiofilm-effect
#5
Ranjit Ghosh, Manash C Das, Arpita Sarkar, Antu Das, Padmani Sandhu, Biswanath Dinda, Yusuf Akhter, Surajit Bhattacharjee, Utpal Ch De
In the context of ethno botanical importance with no phytochemical investigations, Mussaenda roxburghii have been investigated to explore it's phytoconstituents and studies of their antibiofilm activity. Four compounds have been isolated from the aerial parts of this plant and were characterized as 2α, 3β, 19α, 23-tetrahydroxyurs-12-en-28-oic acid (1), β-sitosterol glucoside (4), lupeol palmitate (5) and myoinositol (6). All these compounds were tested for antibacterial and antibiofilm activity against Pseudomonas aeruginosa...
July 7, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28674504/antigliadin-antibodies-aga-igg-are-related-to-neurochemistry-in-schizophrenia
#6
Laura M Rowland, Haley K Demyanovich, S Andrea Wijtenburg, William W Eaton, Katrina Rodriguez, Frank Gaston, Daniela Cihakova, Monica V Talor, Fang Liu, Robert R McMahon, L Elliot Hong, Deanna L Kelly
Inflammation may play a role in schizophrenia; however, subgroups with immune regulation dysfunction may serve as distinct illness phenotypes with potential different treatment and prevention strategies. Emerging data show that about 30% of people with schizophrenia have elevated antigliadin antibodies of the IgG type, representing a possible subgroup of schizophrenia patients with immune involvement. Also, recent data have shown a high correlation of IgG-mediated antibodies between the periphery and cerebral spinal fluid in schizophrenia but not healthy controls, particularly AGA IgG suggesting that these antibodies may be crossing the blood-brain barrier with resulting neuroinflammation...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28635952/yunis-var%C3%A3-n-syndrome-caused-by-biallelic-vac14-mutations
#7
Matthew A Lines, Yoko Ito, Kristin D Kernohan, Wendy Mears, Julie Hurteau-Miller, Sunita Venkateswaran, Leanne Ward, Karine Khatchadourian, Jeff McClintock, Priya Bhola, Philippe M Campeau, Kym M Boycott, Jean Michaud, André Bp van Kuilenburg, Sacha Ferdinandusse, David A Dyment
Yunis-Varón syndrome (YVS) is an autosomal recessive disorder comprising skeletal anomalies, dysmorphism, global developmental delay and intracytoplasmic vacuolation in brain and other tissues. All hitherto-reported pathogenic variants affect FIG4, a lipid phosphatase involved in phosphatidylinositol (3,5)-bisphosphate [PtdIns(3,5)P2] metabolism. FIG4 interacts with PIKfyve, a lipid kinase, via the adapter protein VAC14; all subunits of the resulting complex are essential for PtdIns(3,5)P2 synthesis in the endolysosomal membrane compartment...
September 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28592159/taurine-prevents-ultraviolet-b-induced-apoptosis-in-retinal-ganglion-cells
#8
Wu Dayang, Pang Dongbo
BACKGROUND: Compatible osmolytes accumulation is an active resistance response in retina under ultraviolet radiation and hypertonicity conditions. OBJECTIVE: The purpose of this research is to investigate the protective role of taurine on retina under ultraviolet B radiation. METHODS: Osmolytes transporters was measured by quantitative realtime PCR. Osmolytes uptake was estimated by radioimmunoassay. Cell viability was caculated by MTT assay...
June 7, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28579553/new-sesquiterpene-acid-and-inositol-derivatives-from-inula-montana-l
#9
Elnur Garayev, Gaëtan Herbette, Carole Di Giorgio, Philippe Chiffolleau, David Roux, Huguette Sallanon, Evelyne Ollivier, Riad Elias, Béatrice Baghdikian
A phytochemical investigation of the ethanol extract of leaves and flowers of Inula montana L. led to the isolation of one new sesquiterpene acid called Eldarin (1) and four new inositol derivatives, Myoinositol,1,5-diangelate-4,6-diacetate (2), Myoinositol,1,6-diangelate-4,5-diacetate (3), Myoinositol-1-angelate-4,5-diacetate-6-(2-methylbutirate) (4), Myoinositol-1-angelate-4,5-diacetate-6-isovalerate (5) isolated for the first time, along with eleven known compounds described for the first time in Inula montana, 1β-Hydroxyarbusculin A (6), Artemorin (7), Santamarin (8), Chrysosplenol C (9), 6-Hydroxykaempferol 3,7-dimethyl ether (10), Reynosin (11), Calenduladiol-3-palmitate (12), Costunolide (13), 4-Hydroxy-3,5-dimethoxybenzenemethanol (14), 9β-Hydroxycostunolide (15) and Hispidulin (16)...
July 2017: Fitoterapia
https://www.readbyqxmd.com/read/28578037/bioaccessibility-of-calcium-iron-and-magnesium-in-residues-of-citrus-and-characterization-of-macronutrients
#10
Joyce Grazielle Siqueira Silva, Ana Paula Rebellato, Ralf Greiner, Juliana Azevedo Lima Pallone
The aim of this study was to estimate bioaccessibility of Ca, Fe and Mg in residues of orange, lime, and their mixture, in order to evaluate the effects of cooking in water on mineral bioaccessibility and also to determine the composition of macronutrients and myo-inositol phosphate content. The citrus samples contained on average 9.53g/100 g moisture, 6.09g/100 g protein, 3.23g/100g ash, 3.15g/100g lipids, 34.26g/100g insoluble fiber, 27.88g/100g soluble fiber and 25.64g/100g carbohydrates. The percentage of soluble and dialyzable minerals ranged from 19...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28435103/magnetization-transfer-contrast-and-chemical-exchange-saturation-transfer-mri-features-and-analysis-of-the-field-dependent-saturation-spectrum
#11
Peter C M van Zijl, Wilfred W Lam, Jiadi Xu, Linda Knutsson, Greg J Stanisz
Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation Transfer (CEST) experiments measure the transfer of magnetization from molecular protons to the solvent water protons, an effect that becomes apparent as an MRI signal loss ("saturation"). This allows molecular information to be accessed with the enhanced sensitivity of MRI. In analogy to Magnetic Resonance Spectroscopy (MRS), these saturation data are presented as a function of the chemical shift of participating proton groups, e.g. OH, NH, NH2, which is called a Z-spectrum...
April 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28434274/myoinositol-combined-with-alpha-lipoic-acid-may-improve-the-clinical-and-endocrine-features-of-polycystic-ovary-syndrome-through-an-insulin-independent-action
#12
Simona De Cicco, Valentina Immediata, Daniela Romualdi, Caterina Policola, Anna Tropea, Christian Di Florio, Valeria Tagliaferri, Elisa Scarinci, Silvia Della Casa, Antonio Lanzone, Rosanna Apa
The aim of our study was to investigate the effects of a combined treatment with alpha-lipoic acid (ALA) and myoinositol (MYO) on clinical, endocrine and metabolic features of women affected by polycystic ovary syndrome (PCOS). In this pilot cohort study, forty women with PCOS were enrolled and clinical, hormonal and metabolic parameters were evaluated before and after a six-months combined treatment with ALA and MYO daily. Studied patients experienced a significant increase in the number of cycles in six months (p < 0...
April 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28364102/-value-of-1h-mrs-on-sca3-mjd-diagnosis-and-clinical-course
#13
Wu Xing, Xinxin Liao, Tingting Guan, Fangfang Xie, Lu Shen, Weihua Liao, Xiaoyi Wang
To investigate the value of proton magnetic resonance spectroscopy (1H-MRS) on the diagnosis of SCA3/MJD, and to calculate the correlation between 1H-MRS ratio and the clinical score.
 Methods: Sixteen patients with SCA3/MJD and 19 healthy volunteers were scanned with 1H-MRS. The data of N-acetyl aspartate, creatine, choline-containing compounds, myoinositol, NAA/Cr, Cho/Cr, and mI/Cr ratio were collected, which were grouped for comparative study. The onset patients with SCA3/MJD were evaluated with the International Cooperative Ataxia Rating Scale and Scale for the Assessment and Rating of Ataxia, the correlation between NAA/Cr, Cho/Cr or mI/Cr ratio and the clinical score was calculated...
March 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28358223/ameliorative-effects-of-pyrazinoic-acid-against-oxidative-and-metabolic-stress-manifested-in-rats-with-dimethylhydrazine-induced-colonic-carcinoma
#14
Anil K Sahdev, Vinit Raj, Ashok K Singh, Amit Rai, Amit K Keshari, Arnab De, Amalesh Samanta, Umesh Kumar, Atul Rawat, Dinesh Kumar, Sneha Nath, Anand Prakash, Sudipta Saha
Pyrazinoic acid (PA) is structurally similar to nicotinic acid which acts on G-protein-coupled receptor (GPR109A). GPR109A expresses in colonic and intestinal epithelial sites, and involves in DNA methylation and cellular apoptosis. Therefore, it may be assumed that PA has similar action like nicotinic acid and may be effective against colorectal carcinoma (CRC). CRC was produced via subcutaneous injection of dimethylhydrazine (DMH) at 40 mg/kg body weight once in a week for 4 weeks. After that, PA was administered orally at 2 doses of 10 and 25 mg/kg daily for 15 d to observe the antiproliferative effect...
May 4, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28350397/diagnosis-and-body-mass-index-effects-on-hippocampal-volumes-and-neurochemistry-in-bipolar-disorder
#15
D J Bond, L E Silveira, E L MacMillan, I J Torres, D J Lang, W Su, W G Honer, R W Lam, L N Yatham
We previously reported that higher body mass index (BMI) was associated with greater hippocampal glutamate+glutamine in people with bipolar disorder (BD), but not in non-BD healthy comparator subjects (HSs). In the current report, we extend these findings by examining the impact of BD diagnosis and BMI on hippocampal volumes and the concentrations of several additional neurochemicals in 57 early-stage BD patients and 31 HSs. Using 3-T magnetic resonance imaging and magnetic resonance spectroscopy, we measured bilateral hippocampal volumes and the hippocampal concentrations of four neurochemicals relevant to BD: N-acetylaspartate+N-acteylaspartylglutamate (tNAA), creatine+phosphocreatine (Cre), myoinositol (Ins) and glycerophosphocholine+phosphatidylcholine (Cho)...
March 28, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28348586/inositol-and-in-vitro-fertilization-with-embryo-transfer
#16
REVIEW
G Simi, A R Genazzani, M E R Obino, F Papini, S Pinelli, V Cela, P G Artini
Recently, studies on inositol supplementation during in vitro fertilization program (IVF) have gained particular importance due to the effect of this molecule on reducing insulin resistance improving ovarian function, oocyte quality, and embryo and pregnancy rates and reducing gonadotropin amount during stimulation. Inositol and its isoforms, especially myoinositol (MYO), are often used as prestimulation therapy in infertile patients undergoing IVF cycle. Inositol supplementation started three months before ovarian stimulation, resulting in significant improvements in hormonal responses, reducing the amount of FSH necessary for optimal follicle development and serum levels of 17beta-estradiol measured the day of hCG injection...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28342238/a-peel-off-facial-mask-comprising-myoinositol-and-trehalose-loaded-liposomes-improves-adult-female-acne-by-reducing-local-hyperandrogenism-and-activating-autophagy
#17
Gabriella Fabbrocini, Claudia Capasso, Marianna Donnarumma, Mariateresa Cantelli, Michel Le Maître, Giuseppe Monfrecola, Enzo Emanuele
BACKGROUND: Hyperandrogenism and reduced skin autophagy have been implicated in the pathogenesis of adult female acne (AFA). Here, we tested whether a ready-to-use peel-off facial mask containing myoinositol (an androgen inhibitor) and trehalose-loaded liposomes (as activators of cutaneous autophagy) applied overnight every other day for 60 days can improve AFA. We also sought to investigate the molecular mechanisms underlying the clinical effects. OBJECTIVES: We conducted an uncontrolled, open-label clinical study in 40 cases of AFA to investigate the effect of the facial mask on lesion count, sebum production (measured with the Sebutape® technique), and Global Acne Grading System (GAGS) scale...
March 25, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28331947/-magnetic-resonance-spectroscopy-of-brain-tumors
#18
P Ditter, E Hattingen
BACKGROUND: Conventional magnetic resonance imaging (MRI) under consideration of clinical information enables the correct diagnosis and therapy for the majority of cerebral space-occupying lesions. Some important differential diagnoses, e. g. low vs. high-grade tumors, require additional MRI methods. OBJECTIVE: This article critically discusses the importance of magnetic resonance spectroscopy ((1)H-MRS) in brain tumors. MATERIAL AND METHODS: The concentration of normal and pathological brain metabolites can be non-invasively measured by (1)H-MRS...
June 2017: Der Radiologe
https://www.readbyqxmd.com/read/28304238/remote-motor-system-metabolic-profile-and-surgery-outcome-in-cervical-spondylotic-myelopathy
#19
Sorin C Craciunas, Mircea R Gorgan, Bogdan Ianosi, Phil Lee, Joseph Burris, Carmen M Cirstea
OBJECTIVE In patients with cervical spondylotic myelopathy (CSM), the motor system may undergo progressive functional/structural changes rostral to the lesion, and these changes may be associated with clinical disability. The extent to which these changes have a prognostic value in the clinical recovery after surgical treatment is not yet known. In this study, magnetic resonance spectroscopy (MRS) was used to test 2 primary hypotheses. 1) Based on evidence of corticospinal and spinocerebellar, rubro-, or reticulospinal tract degeneration/dysfunction during chronic spinal cord compression, the authors hypothesized that the metabolic profile of the primary motor cortices (M1s) and cerebellum, respectively, would be altered in patients with CSM, and these alterations would be associated with the extent of the neurological disabilities...
June 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28255341/proton-mr-spectroscopy-and-diffusion-mr-imaging-monitoring-to-predict-tumor-response-to-interstitial-photodynamic-therapy-for-glioblastoma
#20
Magali Toussaint, Sophie Pinel, Florent Auger, Nicolas Durieux, Magalie Thomassin, Eloise Thomas, Albert Moussaron, Dominique Meng, François Plénat, Marine Amouroux, Thierry Bastogne, Céline Frochot, Olivier Tillement, François Lux, Muriel Barberi-Heyob
Despite recent progress in conventional therapeutic approaches, the vast majority of glioblastoma recur locally, indicating that a more aggressive local therapy is required. Interstitial photodynamic therapy (iPDT) appears as a very promising and complementary approach to conventional therapies. However, an optimal fractionation scheme for iPDT remains the indispensable requirement. To achieve that major goal, we suggested following iPDT tumor response by a non-invasive imaging monitoring. Nude rats bearing intracranial glioblastoma U87MG xenografts were treated by iPDT, just after intravenous injection of AGuIX® nanoparticles, encapsulating PDT and imaging agents...
2017: Theranostics
keyword
keyword
52263
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"