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https://www.readbyqxmd.com/read/29742621/mechanisms-of-ketamine-on-mice-hippocampi-shown-by-gas-chromatography-mass-spectrometry-based-metabolomic-analysis
#1
Bin Lian, Jinjun Xia, Xun Yang, Chanjuan Zhou, Xue Gong, Siwen Gui, Qiang Mao, Ling Wang, Pengfei Li, Cheng Huang, Xunzhong Qi, Peng Xie
In the present study, we used a gas chromatography-mass spectrometry-based metabolomics method to evaluate the effects of ketamine on mice hippocampi. Multivariate statistical analysis and ingenuity pathway analysis were then used to identify and explore the potential mechanisms and biofunction of ketamine. Compared with the control (CON) group, 14 differential metabolites that involved amino acid metabolism, energy metabolism, and oxidative stress metabolism were identified. After combination with 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX) administration, six of the 14 metabolites remained significantly differentially expressed between the ketamine (KET) and KET+NBQX groups, including glycine, alanine, glutamine, aspartic acid, myoinositol, and ascorbate, whereas no difference was found in the levels of the other eight metabolites between the KET and KET+NBQX groups, including phosphate, 4-aminobutyric acid, urea, creatine, L-malic acid, galactinol, inosine, and aminomalonic...
May 8, 2018: Neuroreport
https://www.readbyqxmd.com/read/29741097/metabolic-and-structural-imaging-at-7-tesla-after-repetitive-mild-traumatic-brain-injury-in-immature-rats
#2
Emin Fidan, Lesley M Foley, Lee Ann New, Henry Alexander, Patrick M Kochanek, T Kevin Hitchens, Hülya Bayır
Mild traumatic brain injury (mTBI) in children is a common and serious public health problem. Traditional neuroimaging findings in children who sustain mTBI are often normal, putting them at risk for repeated mTBI (rmTBI). There is a need for more sensitive imaging techniques capable of detecting subtle neurophysiological alterations after injury. We examined neurochemical and white matter changes using diffusion tensor imaging of the whole brain and proton magnetic resonance spectroscopy of the hippocampi at 7 Tesla in 18-day-old male rats at 7 days after mTBI and rmTBI...
January 2018: ASN Neuro
https://www.readbyqxmd.com/read/29723775/alterations-in-anterior-cingulate-cortex-myoinositol-and-aggression-in-veterans-with-suicidal-behavior-a-proton-magnetic-resonance-spectroscopy-study
#3
Chandni Sheth, Andrew Prescot, Elliott Bueler, Jennifer DiMuzio, Margaret Legarreta, Perry F Renshaw, Deborah Yurgelun-Todd, Erin McGlade
Studies investigating the neurochemical changes that correspond with suicidal behavior (SB) have not yielded conclusive results. Suicide correlates such as aggression have been used to explore risk factors for SB. Yet the neurobiological basis for the association between aggression and SB is unclear. Aggression and SB are both prevalent in veterans relative to civilian populations. The current study evaluated the relationship between brain chemistry in the anterior (ACC) and the posterior cingulate cortex (POC), as well as the relationship between aggression and SB in a veteran population using proton magnetic resonance spectroscopy (1 H-MRS)...
April 24, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29658345/osmolyte-taurine-induction-in-uva-exposed-human-retinal-pigment-epithelial-cells
#4
Wu Dayang, Pang Dongbo
AIM: To explore the osmolytes expression in UVA stressed human retinal pigment epithelial cells. METHODS: Osmolyte transporters and VEGF mRNA were determined by realtime PCR. Osmolyte uptake were measured by radioimmunoassay. VEGF concentrations were determined by immunoassay and ELISA. Osmolyte transporter TAUT were silenced by siRNA technology. RESULTS: Hypertonicity accelerated osmolyte betaine uptake, myoinositol uptake and taurine uptake, compared to normotonic stress...
April 15, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29587752/alzheimer-like-brain-metabolic-and-structural-features-in-cholesterol-fed-rabbit-detected-by-magnetic-resonance-imaging
#5
Ping Jin, Yongming Pan, Zhiyong Pan, Jianqin Xu, Min Lin, Zhichao Sun, Minli Chen, Maosheng Xu
BACKGROUND: Hypercholesterolemia is known to increase the risk of AD in later life, the purpose of this study is to illustrate brain metabolic and structural changes in a cholesterol-fed rabbit model of Alzheimer's Disease (AD) by using clinical 3 T Magnetic Resonance Imaging (MRI). METHODS: The Institutional Animal Care and Use Committee of Zhejiang Chinese Medical University approved the study. Totally 16 Japanese White Rabbits (JWR) were randomly divided into 2 groups including normal control group fed with routine diet (group NC) and high cholesterol diet group (group CD) fed a 2% cholesterol diet with 0...
March 27, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29541417/metabolic-profiling-of-the-three-neural-derived-embryonal-pediatric-tumors-retinoblastoma-neuroblastoma-and-medulloblastoma-identifies-distinct-metabolic-profiles
#6
Sarah E Kohe, Christopher D Bennett, Simrandip K Gill, Martin Wilson, Carmel McConville, Andrew C Peet
The rare pediatric embryonal tumors retinoblastoma, medulloblastoma and neuroblastoma derive from neuroectodermal tissue and share similar histopathological features despite different anatomical locations and diverse clinical outcomes. As metabolism can reflect genetic and histological features, we investigated whether the metabolism of embryonal tumors reflects their similar histology, shared developmental and neural origins, or tumor location. We undertook metabolic profiling on 50 retinoblastoma, 39 medulloblastoma and 70 neuroblastoma using high resolution magic angle spinning magnetic resonance spectroscopy (1H-MRS)...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29518282/positron-emission-tomography-guided-magnetic-resonance-spectroscopy-in-alzheimer-disease
#7
Nasim Sheikh-Bahaei, S Ahmad Sajjadi, Roido Manavaki, Mary McLean, John T O'Brien, Jonathan H Gillard
OBJECTIVE: To determine whether the level of metabolites in magnetic resonance spectroscopy (MRS) is a representative marker of underlying pathological changes identified in positron emission tomographic (PET) images in Alzheimer disease (AD). METHODS: We performed PET-guided MRS in cases of probable AD, mild cognitive impairment (MCI), and healthy controls (HC). All participants were imaged by 11 C-Pittsburgh compound B (11 C-PiB) and 18 F-fluorodeoxyglucose (18 F-FDG) PET followed by 3T MRS...
April 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29464722/phelipanche-aegyptiaca-parasitism-impairs-salinity-tolerance-in-young-leaves-of-tomato
#8
Amnon Cochavi, Jhonthan Ephrath, Hanan Eizenberg, Shimon Rachmilevitch
The parasite Phelipanche aegyptiaca infests tomato, a crop plant that is commonly cultivated in semi-arid environments, where tomato may be subject to salt stress. Since the relationship between the two stresses - salinity and parasitism - has been poorly investigated in tomato, the effects of P. aegyptiaca parasitism on tomato growing under moderate salinity were examined. Tomatoes were grown with regular or saline water irrigation (3 and 45 mM Cl- , respectively) in soils infested with P. aegyptiaca. The infested plants accumulated higher levels of sodium and chloride ions in the roots, shoots and leaves (old and young) under both salinity levels vs non-infected plants...
February 21, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29428932/metabolite-levels-in-paediatric-brain-tumours-correlate-with-histological-features
#9
Eleni Orphanidou-Vlachou, Sarah E Kohe, Marie-Anne Brundler, Lesley MacPherson, Yu Sun, Nigel Davies, Martin Wilson, Xiaoyan Pan, Theodoros N Arvanitis, Richard G Grundy, Andrew C Peet
AIMS: Metabolite levels can be measured non-invasively using in vivo 1H magnetic resonance spectroscopy (MRS). These tumour metabolite profiles are highly characteristic for tumour type in childhood brain tumours; however, the relationship between metabolite values and conventional histopathological characteristics has not yet been fully established. This study systematically tests the relationship between metabolite levels detected by MRS and specific histological features in a range of paediatric brain tumours...
February 10, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29417844/taurine-reduces-blue-light-induced-retinal-neuronal-cell-apoptosis-in-vitro
#10
Wu Dayang, Pang Dongbo
BACKGROUND: The massive uptake of organic compatible osmolytes is a self-protective response to multiple stressors. OBJECTIVE: This study aimed to determine the protective effects of the osmolyte taurine against blue light-induced apoptosis in retinal neuronal cells in vitro. METHODS: Real-time PCR was used to measure osmolyte transport. Radioimmunoassays were performed to measure osmolyte uptake. Cell Counting Kit-8 assays were conducted to measure cellular viability...
February 27, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29331150/production-of-eicosapentaenoic-acid-by-application-of-a-delta-6-desaturase-with-the-highest-ala-catalytic-activity-in-algae
#11
Haisu Shi, Xue Luo, Rina Wu, Xiqing Yue
Dunaliella salina is a unicellular green alga with a high α-linolenic acid (ALA) level, but a low eicosapentaenoic acid (EPA) level. In a previous analysis of the catalytic activity of delta 6 fatty acid desaturase (FADS6) from various species, FADS6 from Thalassiosira pseudonana (TpFADS6), a marine diatom, showed the highest catalytic activity for ALA. In this study, to enhance EPA production in D. salina, FADS6 from D. salina (DsFADS6) was identified, and substrate specificities for DsFADS6 and TpFADS6 were characterized...
January 13, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29301092/metabolomic-profiling-of-bovine-oviductal-fluid-across-the-oestrous-cycle-using-proton-nuclear-magnetic-resonance-spectroscopy
#12
Julie Lamy, Julie Gatien, Florine Dubuisson, Lydie Nadal-Desbarats, Pascal Salvetti, Pascal Mermillod, Marie Saint-Dizier
In the present study we tested whether regulation of the metabolome in bovine oviductal fluid depended on the stage of the oestrous cycle, the side relative to ovulation and local concentrations of steroid hormones. Luminal fluid samples from both oviducts were collected in the preovulatory, postovulatory, mid- and late luteal phases, from cyclic cows at a local abattoir (18-27 cows per stage and side). The metabolomes were assessed by proton nuclear magnetic resonance spectroscopy (H-NMR). In all, 39 metabolites were identified, among which the amino acid glycine and the energy substrates lactate and myoinositol were the most abundant at all stages...
January 5, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29245250/inositol-supplement-improves-clinical-pregnancy-rate-in-infertile-women-undergoing-ovulation-induction-for-icsi-or-ivf-et
#13
REVIEW
Xiangqin Zheng, Danmei Lin, Yulong Zhang, Yuan Lin, Jianrong Song, Suyu Li, Yan Sun
OBJECTIVE: Pretreatment of myoinositol is a very new method that was evaluated in multiple small studies to manage poor ovarian response in assisted reproduction. This study was to determine the efficacy of myoinositol supplement in infertile women undergoing ovulation induction for intracytoplasmic sperm injection (ICSI) or in vitro fertilization embryo transfer (IVF-ET). METHODS: A meta-analysis and systematic review of published articles evaluating the efficacy of myo-inositol in patients undergoing ovulation induction for ICSI or IVF-ET was performed...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29052180/effectiveness-of-myoinositol-for-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#14
Liuting Zeng, Kailin Yang
PURPOSE: To assess the effectiveness and safety of myoinositol for patients with PCOS. METHODS: In this meta-analysis, data from randomized controlled trials are obtained to assess the effects of myoinositol vs. placebo or western medicine in women with PCOS. The study's registration number is CRD42017064563. The primary outcomes included total testosterone, estradiol (E2) and the homeostatic model assessment (HOMA) of insulin resistance. RESULT: Ten trials involving 573 patients were included...
January 2018: Endocrine
https://www.readbyqxmd.com/read/28986816/effects-of-electroacupuncture-on-metabolic-changes-in-motor-cortex-and-striatum-of-6-hydroxydopamine-induced-parkinsonian-rats
#15
Min Li, Ke Wang, Wen-Ting Su, Jun Jia, Xiao-Min Wang
OBJECTIVE: To explore the possible underlying mechanism by investigating the effect of electroacupuncture (EA) treatment on the primary motor cortex and striatum in a unilateral 6-hydroxydopamine (6-OHDA) induced rat Parkinson's disease (PD) model. METHODS: Male Sprague-Dawley rats were randomly divided into sham group (n=16), model group (n=14), and EA group (n=14). EA stimulation at Dazhui (GV 14) and Baihui (GV20) was applied to PD rats in the EA group for 4 weeks...
October 6, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28958033/an-objective-short-sleep-insomnia-disorder-subtype-is-associated-with-reduced-brain-metabolite-concentrations-in-vivo-a-preliminary-magnetic-resonance-spectroscopy-assessment
#16
Christopher B Miller, Caroline D Rae, Michael A Green, Brendon J Yee, Christopher J Gordon, Angela L D'Rozario, Simon D Kyle, Colin A Espie, Ronald R Grunstein, Delwyn J Bartlett
Objectives: To evaluate brain metabolites in objective insomnia subtypes defined from polysomnography (PSG): insomnia with short sleep duration (I-SSD) and insomnia with normal sleep duration (I-NSD), relative to good sleeping controls (GSCs). Methods: PSG empirically grouped insomnia patients into I-SSD (n = 12: mean [SD] total sleep time [TST] = 294.7 minutes [30.5]) or I-NSD (n = 19: TST = 394.4 minutes [34.9]). 1H magnetic resonance spectroscopy (MRS) acquired in the left occipital cortex (LOCC), left prefrontal cortex, and anterior cingulate cortex was used to determine levels of creatine, aspartate, glutamate, and glutamine (referenced to water)...
November 1, 2017: Sleep
https://www.readbyqxmd.com/read/28846033/metabolic-alterations-of-qinghai-tibet-plateau-pikas-in-adaptation-to-high-altitude
#17
Xue-Feng Cao, Zhen-Zhong Bai, Lan Ma, Shuang Ma, Ri-Li Ge
Cao, Xue-Feng, Zhen-Zhong Bai, Lan Ma, Shuang Ma, and Ri-Li Ge. Metabolic alterations of Qinghai-Tibet plateau pikas in adaptation to high altitude. High Alt Med Biol. 18:219-225, 2017.-To determine specific metabolic alterations in the myocardium of plateau pikas (Ochotona curzoniae) and potential metabolic biomarkers involved in their adaptation to the high-altitude environment of the Qinghai-Tibet Plateau. Ten pikas were captured by traps in the Kekexili Reserve (4630 m a.s.l; n = 5) and at the foot of the Laji Mountain (2600 m a...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28834294/update-on-mycoplasma-hyopneumoniae-infections-in-pigs-knowledge-gaps-for-improved-disease-control
#18
D Maes, M Sibila, P Kuhnert, J Segalés, F Haesebrouck, M Pieters
Mycoplasma hyopneumoniae (M. hyopneumoniae) is the primary pathogen of enzootic pneumonia, a chronic respiratory disease in pigs. Infections occur worldwide and cause major economic losses to the pig industry. The present paper reviews the current knowledge on M. hyopneumoniae infections, with emphasis on identification and analysis of knowledge gaps for optimizing control of the disease. Close contact between infected and susceptible pigs is the main route of M. hyopneumoniae transmission. Management and housing conditions predisposing for infection or disease are known, but further research is needed to better understand M...
August 23, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28825773/the-challenge-of-ovarian-cancer-steps-toward-early-detection-through-advanced-signal-processing-in-magnetic-resonance-spectroscopy
#19
REVIEW
Karen Belkić, Dževad Belkić
Ovarian cancer is a major cause of cancer death among women worldwide, and particularly in Israel. Although the disease at stage IA has 5 year survival rates of over 90%, early detection methods are not sufficiently accurate. Consequently, ovarian cancer is typically diagnosed late, which results in high fatality rates. An excellent candidate for early ovarian cancer detection would be in vivo magnetic resonance spectroscopy (MRS) because it is non-invasive and free of ionizing radiation. In addition, it potentially identifies metabolic features of cancer...
August 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28758940/non-targeted-metabolomics-analysis-of-golden-retriever-muscular-dystrophy-affected-muscles-reveals-alterations-in-arginine-and-proline-metabolism-and-elevations-in-glutamic-and-oleic-acid-in-vivo
#20
Muhammad Abdullah, Joe N Kornegay, Aubree Honcoop, Traci L Parry, Cynthia J Balog-Alvarez, Sara K O'Neal, James R Bain, Michael J Muehlbauer, Christopher B Newgard, Cam Patterson, Monte S Willis
BACKGROUND: Like Duchenne muscular dystrophy (DMD), the Golden Retriever Muscular Dystrophy (GRMD) dog model of DMD is characterized by muscle necrosis, progressive paralysis, and pseudohypertrophy in specific skeletal muscles. This severe GRMD phenotype includes moderate atrophy of the biceps femoris (BF) as compared to unaffected normal dogs, while the long digital extensor (LDE), which functions to flex the tibiotarsal joint and serves as a digital extensor, undergoes the most pronounced atrophy...
July 29, 2017: Metabolites
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