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Medication Allergy

Chang-Ching Wei, Cheng-Li Lin, Te-Chun Shen, An-Chyi Chen
The association between migraine and allergy has remained a subject of debate for more than a century. To systemically investigate the interaction between children with antecedent allergic diseases and their future risks of migraine on reaching school age, we recruited 16,130 children aged 7-18 with migraine diagnosed between 2000 and 2008, and 64,520 matched controls without a history of migraine. The ORs of migraine were calculated for the association with allergic diseases diagnosed before migraine diagnosis...
June 14, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Anne L Ersig, Janet K Williams
INTRODUCTION: Constant vigilance to manage severe food allergies (FAs) can lead to high stress. Additional stress may develop during life-course transitions, such as the transition to college. However, few studies have evaluated everyday and FA-related stress in college students with FA and their parents. This analysis examined experiences of 26 college students with FA and their parents. METHODS: Students and parents completed online surveys in a mixed-methods exploratory study of everyday and FA-related stressors, potential contributing factors, and FA management...
June 12, 2018: Journal of Pediatric Health Care
Christina J Jones, Lauren A Sommereux, Helen E Smith
BACKGROUND: Positive self-care behaviours are more likely in young people who engage with allergy support groups, but reasons for this association are not well understood. OBJECTIVES: This study explored how and why young people engage with allergy support groups to identify what activities and resources are beneficial. METHODS: In-depth, semi-structured interviews were conducted with young people aged 12-21 years who reported engaging with allergy support groups (in person or on-line)...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Leonardo Oliveira Mendonça, Cynthia Mafra Fonseca de Lima, Priscilla Rios Cordeiro Macedo, Victor do Espirito Santo Cunha, Ruppert Ludwig Hahnstadt, Jorge Kalil, Clóvis Eduardo Santos Galvão
CONTEXT: Adverse reactions associated with prick tests are rare but may be present as serious systemic reactions. CASE REPORT: A 38-year-old female nursing technician complained of three episodes of anaphylaxis in one year, all in the workplace. To investigate latex allergy, the patient underwent the prick test with latex, and immediately developed a rash, itchy skin, hoarseness, dyspnea and dry cough. Her condition improved promptly after appropriate measures were established for controlling her anaphylaxis...
June 11, 2018: São Paulo Medical Journal, Revista Paulista de Medicina
Sara Ebrahimi, Gholamreza Khademi, Seyed Ali Jafari, Nona Zaboli Nejad, Abdolreza Norouzy, Bahareh Imani
Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian female neonate presented with severe bloody diarrhea, poor feeding, abdominal distention, and dehydration suggesting severe proctocolitis due to an allergy to the protein in cow's milk...
May 2018: Iranian Journal of Medical Sciences
Lien Mestach, Sara Huygens, An Goossens, Liesbeth Gilissen
BACKGROUND: Acrylates and methacrylates are acrylic resin monomers that are known to induce skin sensitization as a result of their presence in different materials, such as nail cosmetics, dental materials, printing inks, and adhesives. Allergic contact dermatitis resulting from the use of modern wound dressings containing them has only rarely been reported. OBJECTIVES: To describe 2 patients who developed allergic contact dermatitis caused by acrylic-based modern medical dressings and/or adhesives...
June 11, 2018: Contact Dermatitis
William J Kostis, Mrinali Shetty, Yuvraj Singh Chowdhury, John B Kostis
PURPOSE OF REVIEW: This study aims to examine current knowledge on the occurrence, pathophysiology, and treatment of angioedema among patients who receive angiotensin-converting enzyme inhibitors. RECENT FINDINGS: Angiotensin-converting enzyme inhibitors (ACE-I), a medication class used by an estimated 40 million people worldwide, are associated with angioedema that occurs with incidence ranging from 0.1 to 0.7%. The widespread use of ACE-I resulted in one third of all emergency department visits for angioedema...
June 8, 2018: Current Hypertension Reports
A Bonaventure, L Orsi, J Rudant, S Goujon-Bellec, G Leverger, A Baruchel, Y Bertrand, B Nelken, M Pasquet, G Michel, N Sirvent, P Chastagner, S Ducassou, C Thomas, C Besse, D Hémon, J Clavel
BACKGROUND: Previous studies on the putative role of allergy in the aetiology of childhood leukaemia have reported contradictory results. The present study aimed to analyse the relation between a medical history of asthma or eczema and childhood acute lymphoid leukaemia (ALL) in light of potential candidate gene-environment interactions. METHODS: Analyses were based on a subset of 434 cases of ALL and 442 controls successfully genotyped and of European ancestry children enrolled in a French population-based case-control study conducted in 2003-2004...
June 5, 2018: Cancer Epidemiology
Alexandra M Hart, Justine Broecker, Leslieann Kao, Albert Losken
PURPOSE: The increasing rate of opioid abuse warrants standardization of postoperative pain management. The purpose of this study is to analyze the use of opioids in pain control and patient satisfaction following ambulatory breast surgery. METHODS: This is a prospective study of a consecutive series of patients undergoing secondary breast reconstruction [SBR: n=60)] or breast reduction [BR:n=35]. All patients were given a pain questionnaire preoperatively. Postoperatively, women received 30 tablets of oxycodone 5...
June 2, 2018: Plastic and Reconstructive Surgery
Carl M Söderström, Roar Borregaard Medici, Sami Assadzadeh, Søren Følsgaard, Jacob Rosenberg, Mona R Gätke, Matias V Madsen
BACKGROUND: Laparoscopic ventral hernia repair is a common surgical procedure. However, muscle contractions and general muscle tension may impair the surgical view and cause difficulties suturing the hernial defect. Deep neuromuscular blockade (NMB) paralyses the abdominal wall muscles and may help to create better surgical conditions. OBJECTIVES: The current study investigated if deep compared with no NMB improved the surgical view during laparoscopic ventral hernia repair...
June 6, 2018: European Journal of Anaesthesiology
Annelie A Monnier, Jeroen Schouten, Marion Le Maréchal, Gianpiero Tebano, Céline Pulcini, Mirjana Stanic Benic, Vera Vlahovic-Palcevski, Romina Milanic, Niels Adriaenssens, Ann Versporten, Benedikt Huttner, Veronica Zanichelli, Marlies E Hulscher, Inge C Gyssens
Background: This study was conducted as part of the Driving Reinvestment in Research and Development and Responsible Antibiotic Use (DRIVE-AB) project and aimed to develop generic quality indicators (QIs) for responsible antibiotic use in the inpatient setting. Methods: A RAND-modified Delphi method was applied. First, QIs were identified by a systematic review. A complementary search was performed on web sites of relevant organizations. Duplicates were removed and disease and patient-specific QIs were combined into generic indicators...
June 1, 2018: Journal of Antimicrobial Chemotherapy
Bertine M J Flokstra-de Blok, Thecla M Brakel, Marian Wubs, Ben Skidmore, Janwillem W H Kocks, Joanne N G Oude Elberink, Marie-Louise A Schuttelaar, Jantina L van der Velde, Thys van der Molen, Anthony E J Dubois
Background: The allergy management support system (AMSS) was developed to assist general practitioners (GPs) to handle the increasing burden of allergic diseases and facilitates the diagnosis and management of allergy. The aim of this cluster-randomized controlled pilot study was to test the feasibility of this AMSS for primary care. Methods: GPs received diagnostic and management recommendations generated by the AMSS in addition to sIgE-test results (intervention) or GPs received sIgE-test results only (control)...
2018: Clinical and Translational Allergy
Sangeeta Dhami, Arnav Agarwal
PURPOSE OF REVIEW: Cat allergy can manifest as allergic rhinitis, conjunctivitis and/or asthma. With widespread cat ownership and exposure, cat allergy has emerged as a major cause of morbidity. Cat allergen immunotherapy is a potential disease modifying treatment for patients with cat allergy. We examine evidence on the effectiveness, cost-effectiveness and safety of cat allergen immunotherapy and consider the clinical contexts in which it should be prescribed. RECENT FINDINGS: The European Association of Allergy and Clinical Immunology systematic reviews on allergic rhinitis and asthma along with the accompanying guidelines on allergic rhinitis were used as primary sources of evidence...
June 4, 2018: Current Opinion in Allergy and Clinical Immunology
Amy Huang, Christine Cho, Donald Y M Leung, Kanwaljit Brar
Therapeutic regimens for the treatment and long-term management of AD traditionally had a two-fold objective of decreasing skin inflammation and repairing the defective skin barrier. Essential treatments for AD in children should include topical moisturizers for skin hydration and prevention of flares, topical anti-inflammatory medications (e.g. corticosteroids, calcineurin inhibitors, PDE4 inhibitor), allergen/irritant avoidance, and treatment of skin infections. Treatment regimens should be severity-based, and implemented in a stepwise approach tailored to the individual patient...
September 2017: Current Treatment Options in Allergy
Jay M Levin, Spencer Boyle, Robert D Winkelman, Joseph E Tanenbaum, Kalil G Abdullah, Michael P Steinmetz, Thomas E Mroz
STUDY DESIGN: This was a retrospective cohort study. OBJECTIVE: The main objectives of this study were: (1) to determine whether patient-reported allergies (PRAs) are associated with patient satisfaction scores, and (2) to clarify the association between PRAs and preoperative anxiety and depression in a lumbar spine surgery population. SUMMARY OF BACKGROUND DATA: Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey is currently used to measure the patient experience and there is concern that psychosocial factors are unaccounted for...
June 1, 2018: Clinical Spine Surgery
Kevin Z Huang, Elizabeth T Jensen, Hannah X Chen, Lisa E Landes, Kristen A McConnell, M Angie Almond, Douglas T Johnston, Raquel Durban, Laura Jobe, Carrie Frost, Sarah Donnelly, Brady Antonio, Anca M Safta, J Antonio Quiros, Jonathan E Markowitz, Evan S Dellon
OBJECTIVES: Differences in the initial management of pediatric eosinophilic esophagitis (EoE) by practice setting have not been well characterized. We aimed to characterize these differences for sites in the Carolinas EoE Collaborative (CEoEC), a multicenter network of academic and community practices. METHODS: We performed a retrospective cohort study of pediatric EoE patients at five CEoEC sites: University of North Carolina (UNC) Hospital, Charlotte Asthma and Allergy Specialists, Greenville Health Systems, Wake Forest Baptist Medical Center, and the Medical University of South Carolina Hospital...
June 2018: Southern Medical Journal
Federica Tafuro, Luisella Selis, Matteo Goldoni, Mariarita Stendardo, Paola Mozzoni, Erminia Ridolo, Piera Boschetto, Massimo Corradi
OBJECTIVES: Laboratory animal allergy is a highly prevalent occupational disease among exposed workers. The aim of the study was to validate the biomarkers of airway inflammation in laboratory animal (LA) care workers. METHODS: All of the participants in this observational study (63 LA care workers and 64 controls) were administered a clinical questionnaire, underwent spirometry and a skin prick or radioallergosorbent test for common and occupational aeroallergens, and the fraction of exhaled nitric oxide (FeNO50 ), exhaled breath condensate hydrogen peroxide (EBC H2 O2 ) and serum pneumoprotein levels were measured...
June 1, 2018: International Archives of Occupational and Environmental Health
W Jonathan Dunkman, Wendy Rycek, Michael W Manning
Over the past decade, there has been a growing awareness of a new allergic syndrome known as alpha-gal allergy or alpha-gal syndrome, commonly recognized as a red meat allergy. We performed a review of the literature to identify articles that provide both background on this syndrome in general and any reports of reactions to medications or medical devices related to alpha-gal syndrome. Alpha-gal syndrome results from IgE to the oligosaccharide galactose-α-1,3-galactose, expressed in the meat and tissues of noncatarrhine mammals...
May 25, 2018: Anesthesia and Analgesia
Jordan Heath, Larry Hartzell, Claire Putt, Joshua L Kennedy
PURPOSE OF REVIEW: Pediatric chronic rhinosinusitis (CRS) is a common disorder that carries significant morbidity. The diagnosis requires sinus symptoms that persist despite standard medical therapy greater than 3 months. Viral infections, allergies, and anatomic differences in children lead to chronic obstruction of the osteomeatal complex. RECENT FINDINGS: Chronic rhinosinusitis as a diagnosis is a conglomeration of multiple phenotypes and endotypes. As such, the diagnosis and management are complex...
May 29, 2018: Current Allergy and Asthma Reports
Nazanin Samadi, Martina Klems, Eva Untersmayr
OBJECTIVE: The contribution of a dysfunctional intestinal barrier to the onset and progression of a variety of intestinal and extra-intestinal inflammatory diseases is well established. However, the role of the intestinal barrier function in food allergy is less evident. DATA SOURCES: A MEDLINE search identified relevant studies investigating the role of intestinal permeability in food hypersensitivity. STUDY SELECTIONS: This review aimed at integrating cutting edge knowledge from different research fields with focus on the gastrointestinal barrier to evaluate its impact on food adverse reactions...
May 24, 2018: Annals of Allergy, Asthma & Immunology
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