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https://www.readbyqxmd.com/read/28228907/primary-osseous-burkitt-lymphoma-with-nodal-and-intracardiac-metastases-in-a-child
#1
Lina Cadavid, Jorge M Sastoque, Carolina Gutiérrez, Mirna Yabur, Gustavo Molina
Burkitt lymphoma (BL) is the most frequent non-Hodgkin lymphoma in pediatric patients, accounting for approximately 34% of the cases of lymphoma in children. This subtype of non-Hodgkin lymphoma was first described in 1958 as a monoclonal proliferation of B cell lymphocytes. Cardiac involvement of BL in association with osseous compromise and lymphadenopathy is rare and poorly documented. We report a case of femur primary BL in an 8-year-old boy with metastatic cardiac involvement, retroperitoneal and iliofemoral lymphadenopathy, and hepatosplenomegaly...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228842/worldwide-malaria-incidence-and-cancer-mortality-are-inversely-associated
#2
Li Qin, Changzhong Chen, Lili Chen, Ran Xue, Ming Ou-Yang, Chengzhi Zhou, Siting Zhao, Zhengxiang He, Yu Xia, Jianxing He, Pinghua Liu, Nanshan Zhong, Xiaoping Chen
BACKGROUND: Investigations on the effects of malaria infection on cancer mortality are limited except for the incidence of Burkitt's lymphoma (BL) in African children. Our previous murine lung cancer model study demonstrated that malaria infection significantly inhibited tumor growth and prolonged the life span of tumor-bearing mice. This study aims to assess the possible associations between malaria incidence and human cancer mortality. METHODS: We compiled data on worldwide malaria incidence and age-standardized mortality related to 30 types of cancer in 56 countries for the period 1955-2008, and analyzed their longitudinal correlations by a generalized additive mixed model (GAMM), adjusted for a nonlinear year effect and potential confounders such as country's income levels, life expectancies and geographical locations...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28227742/a-computational-model-of-orientation-dependent-activation-of-retinal-ganglion-cells
#3
Timothy Esler, Anthony N Burkitt, David B Grayden, Robert R Kerr, Bahman Tahayori, Hamish Meffin, Timothy Esler, Anthony N Burkitt, David B Grayden, Robert R Kerr, Bahman Tahayori, Hamish Meffin, Anthony N Burkitt, Timothy Esler, Hamish Meffin, David B Grayden, Robert R Kerr, Bahman Tahayori
Currently, a challenge in electrical stimulation for epiretinal prostheses is the avoidance of stimulation of axons of passage in the nerve fiber layer that originate from distant regions of the ganglion cell layer. A computational model of extracellular stimulation that captures the effect of neurite orientation in anisotropic tissue is developed using a modified version of the standard volume conductor model, known as the cellular composite model, embedded in a four layer model of the retina. Simulations are conducted to investigate the interaction of neural tissue orientation, electrode placement, and stimulation pulse duration and amplitude...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227501/feasibility-of-a-chronic-minimally-invasive-endovascular-neural-interface
#4
Nicholas L Opie, Gil S Rind, Sam E John, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley, Nicholas L Opie, Gil S Rind, Sam E John, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley, Sam E John, Stephen M Ronayne, David B Grayden, Nicholas L Opie, Anthony N Burkitt, Terence J O'Brien, Clive N May, Thomas J Oxley, Gil S Rind
Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability of chronic neural recording arrays. We have developed a minimally invasive surgical procedure and an endovascular electrode-array that can be delivered to overlie the cortex through blood vessels. Here, we describe feasibility of the endovascular interface through electrode viability, recording potential and safety. Electrochemical impedance spectroscopy demonstrated that electrode impedance was stable over 91 days and low frequency phase could be used to infer electrode incorporation into the vessel wall...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224662/identification-of-renal-infiltration-based-on-urinary-findings-in-a-child-with-burkitt-leukemia-lymphoma
#5
Zühre Kaya, Nurettin Alıcı, Özlem Ezgi Özmen, Meltem Akgül, Büşra Topuz, Emine Akkuzu
No abstract text is available yet for this article.
February 22, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28221192/lymphoma-and-lactic-acidosis
#6
John W McKay, Dominique Delbeke, Martin P Sandler
A 39-year-old man presented with new onset of sinus congestion, shortness of breath, and diaphoresis. His laboratory tests were notable for hypercalcemia and lactic acidosis. A CT scan of the head demonstrated mild paranasal disease. CT scan of the chest, abdomen, and pelvis demonstrated omental caking with lymphadenopathy and a thickened loop of bowel in the left upper quadrant suggestive of lymphoma. All abdominal lesions seen in the CT were intensely F-FDG avid with diffuse uptake in the bone marrow. There was markedly decreased F-FDG uptake in both the brain and liver...
February 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28209658/relevance-of-id3-tcf3-ccnd3-pathway-mutations-in-pediatric-aggressive-b-cell-lymphoma-treated-according-to-the-nhl-bfm-protocols
#7
Marius Rohde, Bettina R Bonn, Martin Zimmermann, Jonas Lange, Anja Möricke, Wolfram Klapper, Ilske Oschlies, Monika Szczepanowski, Inga Nagel, Martin Schrappe, Markus Loeffler, Reiner Siebert, Alfred Reiter, Birgit Burkhardt
Mature B-cell Non-Hodgkin lymphoma is the most common subtype of Non-Hodgkin lymphoma in childhood and adolescence. B-cell Non-Hodgkin lymphoma are further classified into histological subtypes, with Burkitt lymphoma and Diffuse large B-cell lymphoma being the most common subgroups in pediatric patients. Translocations involving the MYC oncogene are known as relevant but not sufficient hit for Burkitt lymphoma pathogenesis. Recently published large-scale next-generation sequencing studies unveiled sets of additional recurrently mutated genes in samples of pediatric and adult B-cell Non-Hodgkin lymphoma patients...
February 16, 2017: Haematologica
https://www.readbyqxmd.com/read/28203109/a-b-cell-lymphoma-case-that-is-unclassifiable-and-intermediate-between-diffuse-large-b-cell-lymphoma-and-burkitt-lymphoma-of-lacrimal-gland
#8
Tatsuya Yunoki, Jun Murakami, Yukihiro Imagawa, Takahiko Nakajima, Atsushi Hayashi
A 60-year-old woman presented with acute eyelid swelling and a subcutaneous hemorrhage in the right eye. Magnetic resonance imaging showed a spherical tumor of the lacrimal gland. The tumor was removed by the Kroenlein method. We diagnosed as a B-cell lymphoma that is unclassifiable, and intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) (intermediate DLBCL/BL) based on its immunohistopathological examination and c-MYC/IgH rearrangement. We administered six cycles of dose-adjusted-EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin hydrochloride, and rituximab) therapy, and remission of the lymphoma was obtained...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28188132/mir-28-regulates-the-germinal-center-reaction-and-blocks-tumor-growth-in-preclinical-models-of-non-hodgkin-lymphoma
#9
Nahikari Bartolomé-Izquierdo, Virginia G de Yébenes, Angel F Álvarez-Prado, Sonia M Mur, Juan A Lopez Del Olmo, Sergio Roa, Jesus Vazquez, Almudena R R Ramiro
Non-Hodgkin Lymphoma (NHL) comprises a variety of neoplasms, many of which arise from germinal center (GC)-experienced B cells. microRNA-28 (miR-28) is a GC-specific microRNA whose expression is lost in numerous mature B cell neoplasms. Here we show that miR-28 regulates the GC reaction in primary B cells by impairing CSR and memory B and plasma cell differentiation. Deep quantitative proteomics combined with transcriptome analysis identified miR-28 targets involved in cell cycle and B cell receptor signaling...
February 10, 2017: Blood
https://www.readbyqxmd.com/read/28178952/study-of-phytochemical-anti-microbial-anti-oxidant-and-anti-cancer-properties-of-allium-wallichii
#10
Jaya Bhandari, BushraTaj Muhammad, Pratiksha Thapa, Bhupal Govinda Shrestha
BACKGROUND: There is growing interest in the use of plants for the treatment and prevention of cancer. Medicinal plants are currently being evaluated as source of promising anticancer agents. In this paper, we have investigated the anticancer potential of plant Allium wallichii, a plant native to Nepal and growing at elevations of 2300-4800 m. This is the first study of its kind for the plant mentioned. METHODS: The dried plant was extracted in aqueous ethanol. Phytochemical screening, anti-microbial assay, anti-oxidant assay, cytotoxicity assay and the flow-cytometric analysis were done for analyzing different phytochemicals present, anti-microbial activity, anti-oxidant activity and anti-cancer properties of Allium wallichii...
February 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28174917/dop049-inflammatory-dyskinesis-defects-of-nf-%C3%AE%C2%BAb-dynamic-behaviour-as-a-new-potential-biomarker-for-personalized-medicine-in-inflammatory-bowel-disease
#11
G Sellge, S Papoutsopoulou, J Verdier, C Trautwein, F Bergey, M Burkitt, M Burkitt, R Sheibani, M Pierik, D Jonkers, M White, P Paszek, V Martins Dos Santos, P Rosenstiel, W Müller, C Probert
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28161958/comprehensive-metaboproteomics-of-burkitt-s-and-diffuse-large-b-cell-lymphoma-cell-lines-and-primary-tumor-tissues-reveals-distinct-differences-in-pyruvate-content-and-metabolism
#12
Philipp Schwarzfischer, Joerg Reinders, Katja Dettmer, Karsten Kleo, Lora Dimitrova, Michael Hummel, Maren Feist, Dieter Kube, Monika Szczepanowski, Wolfram Klapper, Franziska Taruttis, Julia C Engelmann, Rainer Spang, Wolfram Gronwald, Peter J Oefner
Burkitt's lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) are pathologically and clinically distinct subtypes of aggressive non-Hodgkin B-cell lymphoma. To learn more about their biology, we employed metabolomic and proteomic methods to study both established cell lines as well as cryopreserved and formalin-fixed paraffin-embedded (FFPE) tissue sections of BL and DLBCL. Strikingly, NMR analyses revealed DLBCL cell lines to produce and secrete significantly (padj=1.72 x 10-22) more pyruvic acid than BL cell lines...
February 6, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28160302/autism-spectrum-disorder-and-other-neurobehavioural-comorbidities-in-rare-disorders-of-the-ras-mapk-pathway
#13
Shruti Garg, Ami Brooks, Amy Burns, Emma Burkitt-Wright, Bronwyn Kerr, Susan Huson, Richard Emsley, Jonathan Green
AIM: To investigate the cognitive and behavioural phenotype in rare disorders of the Ras/MAPK pathway, namely Noonan, cardiofaciocutaneous (CFC), and Costello syndromes, particularly prevalence of autism spectrum disorder (ASD) and attention-deficit-hyperactivity disorder (ADHD). METHOD: Fifty children were recruited over 10 months through the regional genetics service and advertisements. A range of parent, child, and observational measures were administered including Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Scale...
February 4, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28151409/helicobacter-pylori-induced-gastric-pathology-insights-from-in-vivo-and-ex-vivo-models
#14
REVIEW
Michael D Burkitt, Carrie A Duckworth, Jonathan M Williams, D Mark Pritchard
Gastric colonization with Helicobacter pylori induces diverse human pathological conditions, including superficial gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma and its precursors. The treatment of these conditions often relies on the eradication of H. pylori, an intervention that is increasingly difficult to achieve and that does not prevent disease progression in some contexts. There is, therefore, a pressing need to develop new experimental models of H...
February 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28149793/our-experience-with-smartphone-and-spherical-lens-for-the-eye-fundus-examination-during-humanitarian-project-in-africa
#15
Alena Furdova, Adriana Furdova, Vladimir Krcmery
To present the experience of eye fundus photo documentation by using the plus 20 diopters spherical Volk lens and a smartphone with 4.2 Mpix camera and LED flash within the screening project of eye disorders in countries where the standard ophthalmology equipment is not available. Totally 241 patients underwent ophthalmology screening examination. The documentation of the eye fundus included patients with Burkitt lymphoma, Kala Azar, malnutrition with unknown etiology, tuberculosis, HIV positive patients, Usher syndrome and hypertension...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28144091/clinicopathological-profile-of-gastrointestinal-lymphomas-in-kashmir
#16
Mehnaaz Sultan Khuroo, Summyia Farooq Khwaja, Ajaz Rather, Zhahid Hassan, Ruby Reshi, Naira Sultan Khuroo
BACKGROUND: The histological categorization of lymphoma has been a source of controversy for many years for both clinicians and pathologists. Clinicopathologic information of gastrointestinal lymphomas in Indian subcontinent is lacking. We studied histopathological spectrum of Primary Gastrointestinal Lymphomas (PGIL) and attempted to classify the G.I. lymphomas based on the recent WHO classification in to major histological types and immunological categories. MATERIAL AND METHODS: This study was done to evaluate the clinicopathological pattern of 100 cases with a histopathological diagnosis of primary gastrointestinal lymphoma at a tertiary care hospital...
October 2016: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28137761/comprehensive-transcriptome-and-mutational-profiling-of-endemic-burkitt-lymphoma-reveals-ebv-type-specific-differences
#17
Yasin Kaymaz, Cliff I Oduor, Hongbo Yu, Juliana A Otieno, John M Ong'echa, Ann M Moormann, Jeffrey A Bailey
: Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein-Barr virus (EBV), unlike sporadic Burkitt Lymphoma (sBL) that occurs with a lower incidence in developed countries. Given these differences and the variable clinical presentation and outcomes, we sought to further understand pathogenesis by investigating transcriptomes using RNA sequencing (RNAseq) from multiple primary eBL tumors compared to sBL tumors...
January 30, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28132716/-18-f-fdg-pet-mri-in-lymphoma-patients
#18
Eva Ferdová, Jiří Ferda, Jan Baxa
The introduction of hybrid PET/MRI imaging using integrated systems into clinical practice has opened up the possibility of reducing the radiation dose from hybrid imaging by eliminating the contribution from computed tomography. Studies comparing the possibilities of PET/CT and PET/MRI imaging demonstrated it is possible to use the advantages of the high contrast resolution of magnetic resonance for soft tissue and bone marrow along with PET records in a quality comparable to PET/CT imaging. The significant feature for PET imaging in Hodgkińs lymphoma is that it is a tissue with high levels of radiopharmaceutical accumulation, which decreases proportionally after successful therapeutic effect, the effect of therapy is assessed using Deauville score system on interim examinations...
January 23, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28130083/how-are-race-cultural-and-psychosocial-factors-associated-with-outcomes-in-veterans-with-spinal-cord-injury
#19
Larissa Myaskovsky, Shasha Gao, Leslie Rm Hausmann, Kellee R Bornemann, Kelly H Burkitt, Galen E Switzer, Michael J Fine, Samuel L Phillips, David Gater, Ann M Spungen, Michael L Boninger
OBJECTIVE: To understand the role of cultural and psychosocial factors in the outcomes of Veteran wheelchair users with spinal cord injury (SCI) to help clinicians identify unique factors faced by their patients and help researchers identify target variables for interventions to reduce disparities in outcomes. DESIGN: Cross-sectional cohort study SETTING: Three urban VA Medical Centers affiliated with academic medical centers. PARTICIPANTS: Of the 516 patients who were eligible to participate, 482 completed the interview and 439 had SCI...
January 24, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28129369/serum-metabolomics-of-burkitt-lymphoma-mouse-models
#20
Fengmin Yang, Jie Du, Hong Zhang, Guorui Ruan, Junfeng Xiang, Lixia Wang, Hongxia Sun, Aijiao Guan, Gang Shen, Yan Liu, Xiaomeng Guo, Qian Li, Yalin Tang
Burkitt lymphoma (BL) is a rare and highly aggressive type of non-Hodgkin lymphoma. The mortality rate of BL patients is very high due to the rapid growth rate and frequent systemic spread of the disease. A better understanding of the pathogenesis, more sensitive diagnostic tools and effective treatment methods for BL are essential. Metabolomics, an important aspect of systems biology, allows the comprehensive analysis of global, dynamic and endogenous biological metabolites based on their nuclear magnetic resonance (NMR) and mass spectrometry (MS)...
2017: PloS One
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