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https://www.readbyqxmd.com/read/29659802/cancer-incidence-in-patients-with-a-high-normal-platelet-count-a-cohort-study-using-primary-care-data
#1
Emily Ankus, Sarah J Price, Obioha C Ukoumunne, William Hamilton, Sarah E R Bailey
Background: A platelet count >400 × 109/l (i.e. thrombocytosis) is a recently discovered risk marker of cancer. The risk of undiagnosed cancer in patients with thrombocytosis is 11.6% for men and 6.2% for women, well above the 3% risk threshold set by National Institute for Health and Care Excellence (NICE) for cancer investigation. Patients with a platelet count at the upper end of the normal range (325-400 × 109/l) could be at increased risk of undiagnosed malignancy. Objective: To quantify the risk of an undiagnosed cancer in patients with a platelet count at the upper end of the normal range...
April 12, 2018: Family Practice
https://www.readbyqxmd.com/read/29657130/the-platelet-lifeline-to-cancer-challenges-and-opportunities
#2
REVIEW
Monika Haemmerle, Rebecca L Stone, David G Menter, Vahid Afshar-Kharghan, Anil K Sood
Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment...
March 19, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29656438/renovascular-hypertension-associated-with-jak2-v617f-positive-myeloproliferative-neoplasms-treated-with-angioplasty-2-cases-and-literature-review
#3
Eikan Mishima, Takehiro Suzuki, Yoichi Takeuchi, Kazumasa Seiji, Noriko Fukuhara, Kei Takase, Hideo Harigae, Takaaki Abe, Sadayoshi Ito
Myeloproliferative neoplasms (MPNs) with Janus kinase 2 (JAK2) mutation are associated with a high risk for occlusive vascular diseases. We report 2 cases of renovascular hypertension associated with JAK2 V617F mutation-positive MPNs and provide a literature review. In Case 1, a 63-year-old woman had resistant hypertension, massive proteinuria, and erythrocytosis. Evaluations revealed right renal artery stenosis causing renovascular hypertension and polycythemia vera with JAK2 V617F mutation. Renin-angiotensin system inhibitors and subsequent angioplasty controlled the blood pressure and the proteinuria resolved...
April 14, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29643185/expression-of-mutant-asxl1-perturbs-hematopoiesis-and-promotes-susceptibility-to-leukemic-transformation
#4
Reina Nagase, Daichi Inoue, Alessandro Pastore, Takeshi Fujino, Hsin-An Hou, Norimasa Yamasaki, Susumu Goyama, Makoto Saika, Akinori Kanai, Yasuyuki Sera, Sayuri Horikawa, Yasunori Ota, Shuhei Asada, Yasutaka Hayashi, Kimihito Cojin Kawabata, Reina Takeda, Hwei-Fang Tien, Hiroaki Honda, Omar Abdel-Wahab, Toshio Kitamura
Additional sex combs like 1 ( ASXL1 ) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic transformation, there is growing evidence that ASXL1 mutations might confer an alteration of function. In this study, we identify that physiological expression of a C-terminal truncated Asxl1 mutant in vivo using conditional knock-in (KI) results in myeloid skewing, age-dependent anemia, thrombocytosis, and morphological dysplasia...
April 11, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29629727/the-association-of-an-elevated-thrombocyte-count-with-clinicopathological-prognostic-factors-and-survival-in-patients-with-uterine-carcinosarcoma
#5
Joseph Menczer, Osnat Elyashiv, Erez Ben-Shem, Ofri Peled, Tally Levy
BACKGROUND: Uterine carcinosarcoma (UCS) is a rare tumor with a poor prognosis. An elevated thrombocyte count and thrombocytosis were found to be associated with poor prognosis in several gynecological tumors. Data regarding an elevated thrombocyte count and thrombocytosis, particularly in UCS, are scarce. OBJECTIVES: To assess the frequency of a preoperative elevated thrombocyte count and of thrombocytosis in UCS patients and their association with clinicopathological prognostic factors and survival...
April 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29602892/essential-thrombocytosis-40-years-after-splenectomy
#6
Oliver Neuhaus, Gabriele Käfer
No abstract text is available yet for this article.
March 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29594208/anemia-leukocytosis-and-thrombocytosis-as-prognostic-factors-in-patients-with-cervical-cancer-treated-with-radical-chemoradiotherapy-a-retrospective-cohort-study
#7
Theodora A Koulis, Elizabeth N Kornaga, Robyn Banerjee, Tien Phan, Prafull Ghatage, Anthony M Magliocco, Susan P Lees-Miller, Corinne M Doll
Introduction: Anemia has long been associated with poor prognosis in patients with cervical cancer. Recently, additional hematologic parameters have emerged as potential indicators of worse outcome in this patient group. In a cohort of cervical cancer patients treated with chemoradiotherapy (CRT) and brachytherapy, we report on the prognostic significance of hematologic parameters including anemia, leukocytosis, neutrophil to lymphocyte ratio (NLR), and thrombocytosis, the effect of combining anemia with other hematologic parameters, and the effect of changes in hemoglobin levels during treatment...
June 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29594193/expression-of-intrahepatic-cd3-cd4-and-cd8-t-cells-in-biliary-atresia
#8
Behairy E Behairy, Nermine Ehsan, Magdy Anwer, Alif Allam, Ibramem El-Henawy, Nesreen Abdel Hameed, Haidy M Zakaria
Aim of the study: Assessment of the expression of cluster of differentiation (CD)3, CD4, and CD8 T cells in biliary atresia (BA) cases in comparison to neonatal cholestasis other than BA. Material and methods: This study included 79 patients: 34 patients with BA (BA group) and 35 patients with neonatal cholestasis due to causes other than BA (cholestasis group), and 10 normal liver donor as a control group. Immunohistochemical staining or CD3, CD4, and CD8 T cells in liver tissues for the 3 groups were evaluated...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29592977/artery-of-percheron-an-unusual-stroke-presentation
#9
Toby Pitts-Tucker, Jeremy Small
An 86-year-old woman was admitted with multiple episodes of transient loss of consciousness. She was initially treated for seizures, and stroke was not considered likely. MRI on the same day of admission showed acute bilateral medial thalamic infarcts in keeping with the Artery of Percheron (AOP) territory infarcts. Investigation for polycythaemia and thrombocytosis showed JAK2 positive myeloproliferative neoplasm.A diagnosis of AOP infarction is often missed or delayed because it is rare and presents with variable neurological symptoms...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29567786/germline-jak2-l611s-mutation-in-a-child-with-thrombocytosis
#10
Bernard Aral, Martine Courtois, Sylviane Ragot, Valentin Bourgeois, Elodie Bottollier-Lemallaz, Claire Briandet, François Girodon
No abstract text is available yet for this article.
March 22, 2018: Haematologica
https://www.readbyqxmd.com/read/29561432/analysis-of-preoperative-blood-platelet-parameters-in-terms-of-diversity-of-epithelial-ovarian-cancer
#11
Katarzyna Bednarska, Magdalena Klink, Zofia Sułowska, Ewa Król, Ewa Głowacka, Hanna Romanowicz, Marek Nowak, Krzysztof Szyłło
Smouldering inflammation, thrombocytosis, and platelet hyper-reactivity are linked to malignancy. The relationships between preoperative diagnostic blood morphology parameters and cancer have been the focus of much interest, because some of these parameters are correlated with advanced cancer stages and poor patient survival rates. This study aimed to perform an observational, retrospective analysis of the intradiversity of blood platelet parameters in patients with different International Federation of Gynaecology and Obstetrics (FIGO) stages and different histological types of epithelial ovarian carcinomas (EOC), and also an analysis of the overall survival rate...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29555611/plateletpheresis-non-operative-management-of-symptomatic-carotid-thrombosis-in-a-patient-with-reactive-thrombocytosis
#12
Raisa C Martínez, Samuel Quaynor, Mohammed Alkhalifah, Fernando D Goldenberg
No abstract text is available yet for this article.
March 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29537938/aggregometry-in-the-settings-of-thrombocytopenia-thrombocytosis-and-antiplatelet-therapy
#13
GianMarco Podda, Mariangela Scavone, Eti Alessandra Femia, Marco Cattaneo
A variety of laboratory tests have been developed, which can diagnose a number of both congenital and acquired disorders of platelet function. Many tests of platelet function measure the ability of platelets to adhere to each other, forming platelet aggregates, which represent the major constituents of hemostatic plugs and of arterial thrombi. Light transmission aggregometry (LTA) is still considered the gold standard of platelet aggregation tests, but other platelet aggregation-based tests are also available...
March 14, 2018: Platelets
https://www.readbyqxmd.com/read/29537114/blood-calcium-glucose-and-haematology-profiles-of-parturient-bitches-diagnosed-with-uterine-inertia-or-obstructive-dystocia
#14
B L Frehner, I M Reichler, S Keller, S Goericke-Pesch, O Balogh
Bitches with dystocia most often present with clinical signs of uterine inertia (UI). The aetiology of myometrial dysfunction in most of these cases is still not elucidated. We compared blood ionized calcium (iCa) and glucose concentrations in bitches diagnosed with primary UI (PUI, n = 14), secondary UI (SUI, n = 6) or obstructive dystocia (OD, n = 6), and we described their haematology profiles. Bitches diagnosed with UI had a patent birth canal and delivered no puppies yet (PUI) or only part of the whole litter (SUI)...
March 14, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29536526/modeling-and-simulation-support-eltrombopag-dosing-in-pediatric-patients-with-immune-thrombocytopenia
#15
Mary B Wire, Xiaobin Li, Jianping Zhang, William Sallas, Vassilios Aslanis, Taoufik Ouatas
Our objective was to support initial eltrombopag doses and dose titration based on modeling and simulation of plasma exposure and platelet count response in pediatric patients aged 1-17 years with previously treated chronic immune thrombocytopenia enrolled in 2 clinical studies. Data from 168 pediatric patients were used to develop a life-span population pharmacokinetic and pharmacodynamic model including 3 pharmacokinetic and 4 pharmacodynamic compartments enabling simulation of platelet counts for various starting doses and dose titration schedules...
March 14, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29536126/peri-operative-risk-factors-for-complications-of-free-flaps-in-traumatic-wounds-a-cross-sectional-study
#16
Raquel Bernardelli Iamaguchi, Renan Lyuji Takemura, Gustavo Bersani Silva, Jairo Andre de Oliveira Alves, Luciano Ruiz Torres, Alvaro Baik Cho, Teng Hsiang Wei, Marcelo Rosa de Rezende, Rames Mattar
INTRODUCTION: Indication of free tissue transfer for limb reconstruction continues to grow, and despite the good results with this treatment option, complications can impair the functional results and cause a raise in health costs, with prolonged hospitalization. Therefore, peri-operative surgical information and comorbidities were described and analyzed, for identification of independent risk factors for complications of free flaps results for traumatic wounds. For our knowledge, intraoperative ischemia time of free flap was not previously studied for post-traumatic limb reconstruction, which could influence results, in these traumatic cases, with the highest rates of complications among microsurgical flap reconstructions...
March 13, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29516275/polycythemia-vera
#17
REVIEW
Jerry L Spivak
Polycythemia vera (PV) is the most common myeloproliferative neoplasm (MPN), the ultimate phenotype of the JAK2 V1617F mutation, the MPN with the highest incidence of thromboembolic complications, which usually occur early in the course of the disease, and the only MPN in which erythrocytosis occurs. The classical presentation of PV is characterized by erythrocytosis, leukocytosis, and thrombocytosis, often with splenomegaly and occasionally with myelofibrosis, but it can also present as isolated erythrocytosis with or without splenomegaly, isolated thrombocytosis or isolated leukocytosis, or any combination of these...
March 7, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29515972/genetic-alterations-in-essential-thrombocythemia-progression-to-acute-myeloid-leukemia-a-case-series-and-review-of-the-literature
#18
Jackline P Ayres-Silva, Martin H Bonamino, Maria E Gouveia, Barbara C R Monte-Mor, Diego F Coutinho, Adelmo H Daumas, Cristiana Solza, Esteban Braggio, Ilana Renault Zalcberg
The genetic events associated with transformation of myeloproliferative neoplasms (MPNs) to secondary acute myeloid leukemia (sAML), particularly in the subgroup of essential thrombocythemia (ET) patients, remain incompletely understood. Deep studies using high-throughput methods might lead to a better understanding of genetic landscape of ET patients who transformed to sAML. We performed array-based comparative genomic hybridization (aCGH) and whole exome sequencing (WES) to analyze paired samples from ET and sAML phases...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29508552/coexistence-of-jak2-or-calr-mutation-is-a-rare-but-clinically-important-event-in-chronic-myeloid-leukemia-patients-treated-with-tyrosine-kinase-inhibitors
#19
K Lewandowski, M Gniot, M Wojtaszewska, Z Kanduła, R Becht, E Paczkowska, E Mędraś, E Wasilewska, M Iwoła
INTRODUCTION: There are 7 designated conditions under the category of myeloproliferative neoplasms (MPN), including chronic myelogenous leukemia (CML) and classical MPN, that is, polycythemia vera (PV), essential thrombocythaemia (ET), and primary myelofibrosis (PMF). Recently, reports about Philadelphia and JAK2 V617F-positive MPN cases have been described in literature. The coexistence of different molecular defects may change the clinical and laboratory manifestation of MPN and may result in an inappropriate interpretation of the response to treatment with tyrosine kinase inhibitors in CML patients...
March 6, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29499633/preliminary-investigation-about-the-expression-of-tubulin-in-platelets-from-patients-with-iron-deficiency-anemia-and-thrombocytosis
#20
Kam Chau Yung, Ze Wen Zhang, Wen Jun Yu, Jin Feng Qiu, Cheng Wei Xu, Chun Ling He, Xian Ru Xu, Jun Yin
OBJECTIVE: In order to inquire into the pathogenesis of increased platelet counts in peripheral blood of patients with iron deficiency anemia (IDA), the phenomenon of thrombocytosis was confirmed, and then the expression of tubulin within platelets from IDA patients was investigated. METHODS: Peripheral blood samples were collected from 79 patients with IDA and were divided into 2 groups, group of IDA with normal platelet counts (34 cases), and group of IDA with increased platelet counts (thrombocytosis) (45 cases)...
March 2, 2018: Hematology (Amsterdam, Netherlands)
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