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https://www.readbyqxmd.com/read/28445777/five-year-follow-up-after-laparoscopic-large-nerve-resection-for-deep-infiltrating-sciatic-nerve-endometriosis
#1
Marc Possover
STUDY OBJECTIVE: To report neurologic follow-up of patients after laparoscopic large resection of deep infiltrating endometriosis of the sciatic nerve. DESIGN: Prospective clinical case series (Canadian Task Force classification I). SETTING: Tertiary referral unit specializing in advanced gynecologic surgery and neuropelveology. PATIENTS: All data for patients who underwent laparoscopic surgery for endometriosis of the sciatic nerve between 2004 and 2016 (N = 259) were documented prospectively...
April 23, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28442211/leigh-like-neuroimaging-features-associated-with-new-biallelic-mutations-in-opa1
#2
Anna Rubegni, Tiziana Pisano, Giacomo Bacci, Alessandra Tessa, Roberta Battini, Elena Procopio, Sabrina Giglio, Rosa Pasquariello, Filippo Maria Santorelli, Renzo Guerrini, Claudia Nesti
Behr syndrome is characterized by the association of early onset optic atrophy, cerebellar ataxia, pyramidal signs, peripheral neuropathy and mental retardation. Recently, some cases were reported to be caused by biallelic mutations in OPA1. We describe an 11-year-old girl (Pt1) and a 7-year-old boy (Pt2) with cognitive delay, ataxic gait and clinical signs suggestive of a peripheral neuropathy, with onset in early infancy. In Pt1 ocular fundus examination revealed optic disk pallor whereas Pt2 exhibited severe optic atrophy...
April 15, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28441826/-a-childhood-onset-rapid-onset-dystonia-parkinsonism-family-with-atp1a3-gene-mutation-and-literatures-review
#3
C L Zhang, F Yin, F He, N Gai, Z Q Shi, J Peng
Objective: To explore clinical characteristics, treatment, and prognosis of a family with childhood-onset rapid-onset dystonia parkinsonism (RDP) caused by ATP1A3 gene mutation and review literatures. Method: The clinical data of a RDP child, his brother and mother had been analyzed retrospectively. This family was admitted to Xiangya Hospital in January 2016. DNA samples were analyzed by the next-generation sequencing and confirmed by Sanger sequencing. Related literature from PubMed, Online Mendelian Inheritance in Man (OMIM), CNKI and Wanfang databases to date (up to October 2016) with"Rapid-onset dystonia-parkinsonism"RDP"DYT12" as key words was reviewed...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28440888/training-dual-tasks-together-or-apart-in-parkinson-s-disease-results-from-the-duality-trial
#4
Carolien Strouwen, Esther A L M Molenaar, Liesbeth Münks, Samyra H J Keus, Jan C M Zijlmans, Wim Vandenberghe, Bastiaan R Bloem, Alice Nieuwboer
BACKGROUND AND OBJECTIVES: Many controversies surround the usefulness of dual-task training in Parkinson's disease (PD). This study (1) compared the efficacy of two different dual-task training programs for improving dual-task gait and (2) assessed the possible fall risk of such training. METHODS: Patients (N = 121) with a diagnosis of PD (aged 65.93 [±9.22] years, Hoehn and Yahr stage II-III on-medication) were randomized to (1) a consecutive group in which gait and cognitive tasks were trained separately or (2) an integrated group in which gait and cognitive tasks were trained simultaneously...
April 25, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28433867/validity-and-repeatability-of-inertial-measurement-units-for-measuring-gait-parameters
#5
Edward P Washabaugh, Tarun Kalyanaraman, Peter G Adamczyk, Edward S Claflin, Chandramouli Krishnan
Inertial measurement units (IMUs) are small wearable sensors that have tremendous potential to be applied to clinical gait analysis. They allow objective evaluation of gait and movement disorders outside the clinic and research laboratory, and permit evaluation on large numbers of steps. However, repeatability and validity data of these systems are sparse for gait metrics. The purpose of this study was to determine the validity and between-day repeatability of spatiotemporal metrics (gait speed, stance percent, swing percent, gait cycle time, stride length, cadence, and step duration) as measured with the APDM Opal IMUs and Mobility Lab system...
April 12, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28433844/neurological-decline-in-an-elderly-with-repaired-myelomeningocele-complicated-with-lumbar-canal-stenosis-a-case-report
#6
Shingo Matsuda, Satoshi Yamaguchi, Yosuke Kajihara, Masaaki Takeda, Manish Kolakshyapati, Kaoru Kurisu
BACKGROUND: Tethered cord syndrome is a well-known complication after myelomeningocele (MMC) repair in childhood. However, late complications in adults with a repaired MMC are not well understood. In particular, the influence of a degenerative spinal deformity on a sustained tethered cord is still unclear. CASE DESCRIPTION: A 63-year-old man with a repaired MMC presented with a progressive gait disturbance and numbness in both lower limbs. Magnetic resonance images demonstrated that the tethered spinal cord was compressed by severe canal stenosis along the entire lumbar spine...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28431829/utility-of-the-new-movement-disorder-society-clinical-diagnostic-criteria-for-parkinson-s-disease-applied-retrospectively-in-a-large-cohort-study-of-recent-onset-cases
#7
Naveed Malek, Michael A Lawton, Katherine A Grosset, Nin Bajaj, Roger A Barker, Yoav Ben-Shlomo, David J Burn, Tom Foltynie, John Hardy, Huw R Morris, Nigel M Williams, Nicholas Wood, Donald G Grosset
OBJECTIVE: To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients. METHODS: Recently diagnosed (<3.5 years) PD cases fulfilling United Kingdom (UK) brain bank criteria in Tracking Parkinson's, a UK multicenter prospective natural history study were assessed by retrospective application of the MDS criteria. RESULTS: In 2000 cases, 1835 (91.7%) met MDS criteria for PD, either clinically established (n = 1261, 63...
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28422549/obesity-is-associated-with-altered-plantar-pressure-distribution-in-elderly-women
#8
Silvia Gonçalves Ricci Neri, André Bonadias Gadelha, Ana Luiza Matias Correia, Juscélia Cristina Pereira, Ana Cristina de David, Ricardo Moreno Lima
Increased plantar pressure has been found to be related with greater risk of falling. Although there is evidence suggesting that obesity is linked to foot disorders, the association between obesity and plantar pressure of older adults has been poorly investigated. The purpose of this study was to examine the association between obesity and plantar pressure distribution and to explore its relationship with body fat distribution. Two hundred and eleven elderly women took part in this cross-sectional study. Body mass index were taken for obesity classification...
April 19, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28422031/the-importance-of-labyrinthine-examination-in-the-prognosis-and-therapy-for-balance-in-spinocerebellar-ataxia
#9
João Henrique Faryniuk, Bianca Simone Zeigelboim, Hélio Afonso Ghizoni Teive, Vinicius Ribas Fo, Paulo Breno Noronha Liberalesso, Jair Mendes Marques
INTRODUCTION: Spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative diseases that are characterized by the presence of progressive cerebellar ataxia. OBJECTIVE: Identify vestibular disorders and demonstrate the importance of labyrinthine examination in the prognosis and therapy for balance in patients with SCAs. MATERIALS AND METHODS: The study had a retrospective cross-sectional design and evaluated 57 patients, mean age of 41...
April 19, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28420979/evidence-for-a-selectively-regulated-prioritization-shift-depending-on-walking-situations-in-older-adults
#10
Dina Salkovic, Markus A Hobert, Carolin Bellut, Florian Funer, Sarah Renno, Linda Haertner, Sandra E Hasmann, Jana Staebler, Johanna Geritz, Ulrike Suenkel, Andreas J Fallgatter, Gerhard W Eschweiler, Daniela Berg, Walter Maetzler
Background: Older adults have increased risks of balance issues and falls when walking and performing turns in daily situations. Changes of prioritization during different walking situations associated with dual tasking may contribute to these deficits. The objective of this study was therefore to investigate whether older adults demonstrate changes of prioritization during different walking paths. Methods: In total, 1,054 subjects with an age range from 50 to 83 years were selected from the first follow-up visit of the TREND (Tuebinger evaluation of Risk factors for Early detection of Neurodegenerative Disorders) study...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28413999/improving-sensitivity-to-detect-mild-cognitive-impairment-cognitive-load-dual-task-gait-speed-assessment
#11
Rebecca K MacAulay, Mark T Wagner, Dana Szeles, Nicholas J Milano
OBJECTIVES: Longitudinal research indicates that cognitive load dual-task gait assessment is predictive of cognitive decline and thus might provide a sensitive measure to screen for mild cognitive impairment (MCI). However, research among older adults being clinically evaluated for cognitive concerns, a defining feature of MCI, is lacking. The present study investigated the effect of performing a cognitive task on normal walking speed in patients presenting to a memory clinic with cognitive complaints...
April 17, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28412603/impairments-of-balance-stepping-reactions-and-gait-in-people-with-cervical-dystonia
#12
Christopher Barr, Rhiannon Barnard, Lauren Edwards, Sheila Lennon, Lynley Bradnam
BACKGROUND: Impaired balance is common in neurological disorders. Cervical dystonia is a neurological movement disorder affecting the neck. The effect of this aberrant head posture on physical function is unknown. OBJECTIVES: To compare balance, mobility, gait and stepping reactions between ten people with cervical dystonia and ten control adults. METHODS: Spatiotemporal gait parameters and walking speed were assessed using a computerised walkway...
April 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28401818/-analysing-gait-in-the-gp-s-consulting-room
#13
T van Meulenbroek, I P J Huijnen, G H H Meys, G M Rommers
Gait disorders are often seen in the general practitioner (GP)'s consulting room. Orthopaedic or neurological problems may lead to abnormalities in gait. A careful analysis is important to advice or refer the patient for additional diagnostics or treatment. Basic gait analysis can be performed on any patient by applying a systematic stepwise observation. This is illustrated here by three case reports. This observation starts by looking at parameters such as walking speed, safety, efficiency etc. Analysis of biomechanical pattern such as step frequency, stride length and a detailed analysis of the different joint movements during the stance and swing phase can subsequently be performed...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28399105/-treatment-of-syringomyelia-associated-with-chiari-1-malformation
#14
A A Zuev, G V Kostenko
Syringomyelia (SM) develops due to the disturbance of cerebrospinal fluid dynamics, spinal fixation or a spinal tumor. The disturbance of cerebrospinal fluid dynamics in the area of the foramen magnum leads to the progression of SM in Chiari 1 malformation (CM1). CM1 is the most prevalent pathology of craniovertebral junction associated with SM. The prevalence of CM1 varies from 3 to 8 per 100 000 population but SM is diagnosed in 65% of patients with CM1. Clinical symptoms of CM1 and SM include pain in the occipital area, gait disturbances due to sensitive ataxia, dissociated sensory disorders, dysphagia, paresis of the extremities...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28398224/inertial-sensor-based-robust-gait-analysis-in-non-hospital-settings-for-neurological-disorders
#15
Can Tunca, Nezihe Pehlivan, Nağme Ak, Bert Arnrich, Gülüstü Salur, Cem Ersoy
The gold standards for gait analysis are instrumented walkways and marker-based motion capture systems, which require costly infrastructure and are only available in hospitals and specialized gait clinics. Even though the completeness and the accuracy of these systems are unquestionable, a mobile and pervasive gait analysis alternative suitable for non-hospital settings is a clinical necessity. Using inertial sensors for gait analysis has been well explored in the literature with promising results. However, the majority of the existing work does not consider realistic conditions where data collection and sensor placement imperfections are imminent...
April 11, 2017: Sensors
https://www.readbyqxmd.com/read/28397001/gait-ataxia-in-humans-vestibular-and-cerebellar-control-of-dynamic-stability
#16
Roman Schniepp, Ken Möhwald, Max Wuehr
During human locomotion, vestibular feedback control is fundamental for maintaining dynamic stability and adapting the gait pattern to external circumstances. Within the supraspinal locomotor network, the cerebellum represents the key site for the integration of vestibular feedback information. The cerebellum is further important for the fine-tuning and coordination of limb movements during walking. The aim of this review article is to highlight the shared structural and functional sensorimotor principles in vestibular and cerebellar locomotion control...
April 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28381508/clinical-manifestations-of-the-anti-iglon5-disease
#17
Carles Gaig, Francesc Graus, Yarko Compta, Birgit Högl, Luis Bataller, Norbert Brüggemann, Caroline Giordana, Anna Heidbreder, Katya Kotschet, Jan Lewerenz, Stefan Macher, Maria J Martí, Teresa Montojo, Jesus Pérez-Pérez, Inmaculada Puertas, Caspar Seitz, Mateus Simabukuro, Nieves Téllez, Klaus-Peter Wandinger, Alex Iranzo, Guadalupe Ercilla, Lidia Sabater, Joan Santamaría, Josep Dalmau
OBJECTIVE: To report the presentation, main syndromes, human leukocyte antigen (HLA) association, and immunoglobulin G (IgG) subclass in the anti-IgLON5 disease: a disorder with parasomnias, sleep apnea, and IgLON5 antibodies. METHODS: This was a retrospective clinical analysis of 22 patients. The IgG subclass was determined using reported techniques. RESULTS: Patients' median age was 64 years (range 46-83). Symptoms that led to initial consultation included sleep problems (8 patients; 36%), gait abnormalities (8; 36%), bulbar dysfunction (3; 14%), chorea (2; 9%), and cognitive decline (1; 5%)...
April 5, 2017: Neurology
https://www.readbyqxmd.com/read/28380321/gait-analysis-and-clinical-correlations-in-early-parkinson-s-disease
#18
M Pistacchi, M Gioulis, F Sanson, E De Giovannini, G Filippi, F Rossetto, S Zambito Marsala
The aim of our study was to identify and quantify spatiotemporal and kinematic gait parameters obtained by 3D gait analysis (GA) in a group of Parkinson's disease (PD) patients compared with healthy subjects in order to investigate whether early PD patients could present an abnormal gait pattern. Forty-four patients affected by early-stage PD compared with a control group were analyzed. All participants were evaluated with 3D GA in the gait laboratory. The greatest significance in temporal parameters was found in cadence (102...
January 2017: Functional Neurology
https://www.readbyqxmd.com/read/28376829/preserved-gait-kinematics-during-controlled-body-unloading
#19
L Awai, M Franz, C S Easthope, H Vallery, A Curt, M Bolliger
BACKGROUND: Body weight supported locomotor training was shown to improve walking function in neurological patients and is often performed on a treadmill. However, walking on a treadmill does not mimic natural walking for several reasons: absent self-initiation, less active retraction of leg required and altered afferent input. The superiority of overground training has been suggested in humans and was shown in rats demonstrating greater plasticity especially in descending pathways compared to treadmill training...
April 4, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28369393/selective-rescue-of-heightened-anxiety-but-not-gait-ataxia-in-a-premutation-90cgg-mouse-model-of-fragile-x-associated-tremor-ataxia-syndrome
#20
Hoanna Castro, Emre Kul, Ronald A M Buijsen, Lies-Anne W F M Severijnen, Rob Willemsen, Renate K Hukema, Oliver Stork, Mónica Santos
A CGG-repeat expansion in the premutation range in the Fragile X mental retardation 1 gene (FMR1) has been identified as the genetic cause of Fragile X-associated tremor/ataxia syndrome (FXTAS), a late-onset neurodegenerative disorder that manifests with action tremor, gait ataxia and cognitive impairments. In this study we used a bigenic mouse model, in which expression of a 90CGG premutation tract is activated in neural cells upon doxycycline (DOX) administration - P90CGG mouse model. We here demonstrate the behavioural manifestation of clinically relevant features of FXTAS patients and premutation carrier individuals in this inducible mouse model...
March 22, 2017: Human Molecular Genetics
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