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Meso esophageal

Serdar Kirmizi, Cuneyt Kayaalp, Sezai Yilmaz
A 33-year-old male with abdominal distention after meals was admitted to the hospital. He had a history of surgery for hydatid liver cyst. The cyst was located at the liver hilum and there were portal venous thrombosis and cavernous transformation. It had been treated with partial cystectomy, omentoplasty and albendazole. Two years later at the admission to our center, his laboratory tests were in normal ranges. Abdominal imaging methods revealed splenomegaly, portal vein thrombosis, cavernous transformation and the previously operated hydatid liver cyst...
2016: Gastroenterology and Hepatology From Bed to Bench
Keigo Matsubara, Yoshihiko Kumai, Yuta Kamenosono, Yasuhiro Samejima, Eiji Yumoto
OBJECTIVES/HYPOTHESIS: To determine the effects of three different chin-down maneuvers on swallowing pressure (SP) in healthy young adults using high-resolution manometry (HRM). STUDY DESIGN: Repeated measures with subjects serving as their own controls. METHODS: Twenty-six healthy subjects (average age 26.4 [range 21-35] years) swallowed 5 mL of cold water to examine the maximum swallowing pressure (MSP) at the velopharynx, meso-hypopharynx, and upper esophageal sphincter (UES), and to determine the duration of lowered SP at the UES using HRM...
February 2016: Laryngoscope
Li-Jun Zhang, Jun Bian, Lei-Lei Bao, Hai-Fei Chen, Yi-Jia Yan, Li Wang, Zhi-Long Chen
PURPOSE: Photodynamic therapy (PDT) is a promising noninvasive treatment, which has been approved by the US Food and Drug Administration for the treatment of localized tumors. With the aim to select an appropriate photosensitizer for tumor treatment in PDT, the antitumor effect of a novel chlorin-based photosensitizer, meso-tetra (3-morphlinomethyl-4-methoxyphenyl) chlorin (TMMC) (Fig. 1a) on two types of human malignant tumor cells in vitro and a esophageal cancer model in nude mice, was evaluated in the present paper...
September 2014: Journal of Cancer Research and Clinical Oncology
Arianna Bertocchini, Giuseppe d'Ambrosio, Chiara Grimaldi, Laura del Prete, Fabrizio di Francesco, Piergiorgio Falappa, Lidia Monti, Jean de Ville de Goyet
INTRODUCTION: Portal vein aneurysms (PVAs) are usually located at the vein trunk or at its bifurcation, rarely intra-hepatic, or at the umbilical portion. Etiology remains unclear. METHODS: Three children with PVA were identified over a 5-year period. PVA anatomy was assessed by Doppler Ultrasound, Angio CT/MRI, and trans-jugular retrograde portography. RESULTS: Three children with intrahepatic PVA (including the umbilical portion) were identified during assessment for pre-hepatic portal hypertension: all had splenomegaly and hypersplenism...
March 2014: Journal of Pediatric Surgery
Keigo Matsubara, Yoshihiko Kumai, Yasuhiro Samejima, Eiji Yumoto
OBJECTIVES/HYPOTHESIS: To measure the swallowing pressure (SP) of normal subjects using a 2.64-mm-diameter high-resolution manometry (HRM) catheter with 36 circumferential sensors. STUDY DESIGN: Repeated measures with subjects serving as controls. METHODS: Thirty healthy subjects swallowed water at different temperatures and volumes to examine the maximum SP at the velopharynx, meso-hypopharynx, upper esophageal sphincter (UES), and cervical esophagus, and the duration of lowered pressure at the UES...
March 2014: Laryngoscope
Timothy B Lautz, Lisa A Keys, Joseph C Melvin, Joy Ito, Riccardo A Superina
BACKGROUND: Consequences of extrahepatic portal vein obstruction (EHPVO) include variceal bleeding and hypersplenism due to portal hypertension, as well as metabolic abnormalities secondary to impaired portal venous circulation. The purpose of this study was to compare the effectiveness of meso-Rex bypass and portosystemic shunt (PSS) for reversing these symptoms in children with EHPVO. STUDY DESIGN: All children with idiopathic EHPVO evaluated for potential meso-Rex bypass at a single institution between 1997 and 2010 were reviewed...
January 2013: Journal of the American College of Surgeons
Amy S Izon, Paul Jose, Jeremy D Hayden, Heike I Grabsch
BACKGROUND: Differences in the extent and quality of surgical resection for esophageal cancer may influence the pathological staging and patient outcome. There are no data in the literature qualitatively and/or quantitatively characterizing esophagectomy specimens. METHODS: Macroscopic images of 161 esophagectomy specimens were analyzed retrospectively. The extent of resection was qualitatively classified as "muscularis propria," "intra-meso-esophageal," or "meso-esophageal...
March 2013: Annals of Surgical Oncology
Jean de Ville de Goyet, Giuseppe D'Ambrosio, Chiara Grimaldi
The management of children with portal hypertension has dramatically changed during the past decade, with an improvement in outcome. This has been achieved by improved efficiency of endoscopic variceal control and the success of liver transplantation. Emergency surgical shunt procedures are rarely required, with acute bleeding episodes generally controlled endoscopically or, occasionally in adults, by interventional radiological procedures. Portosystemic shunts may be considered as a bridge to transplant in adults but are rarely used in this context in children...
August 2012: Seminars in Pediatric Surgery
Kenji Takasaki, Hiroshi Umeki, Minoru Hara, Hidetaka Kumagami, Haruo Takahashi
OBJECTIVE: To evaluate the effect of effortful swallow on pharyngeal pressure while swallowing saliva and water using a novel high-resolution manometry (HRM) system. STUDY DESIGN: Case series with planned data collection. SETTING: Nagasaki University Hospital. SUBJECTS AND METHODS: Eighteen asymptomatic Japanese adult volunteers were studied. A solid-state HRM assembly with 36 circumferential sensors spaced 1 cm apart was positioned from the velopharynx to the upper esophagus to record pressures while swallowing...
January 2011: Otolaryngology—Head and Neck Surgery
Stefan Scholz, Khalid Sharif
Management of children with portal hypertension has evolved considerably over the past decades. Development of physiologic shunts (meso-Rex bypass) and successful liver transplant has changed the paradigm of portal hypertension surgery. Children with pre-hepatic portal hypertension are investigated and, if suitable, candidates are offered the mesenteric-to-left portal vein bypass (meso-Rex) preemptively, before development of symptoms of portal hypertension. Aggressive medical management, endoscopic ligation of bleeding varices, and radiologically placed intrahepatic stents have greatly reduced the need for emergent surgical procedures...
June 2011: Current Gastroenterology Reports
Batia Weiss, Eyal Shteyer, Asaf Vivante, Drora Berkowitz, Shimon Reif, Zvi Weizman, Yoram Bujanover, Rivka Shapiro
AIM: To study the management and outcome of children with extrahepatic portal vein obstruction (EHPVO) in a whole country population. METHODS: A nationwide multicenter retrospective case series of children with EHPVO was conducted. Data on demographics, radiographic studies, laboratory workup, endoscopic and surgical procedures, growth and development, were extracted from the patients' charts. Characteristics of clinical presentation, etiology of EHPVO, management and outcome were analyzed...
October 21, 2010: World Journal of Gastroenterology: WJG
Masato Shinkai, Youkatsu Ohhama, Shohei Honda, Norihiko Kitagawa, Kyoko Mochizuki, Hiroshi Take, Yoshihiro Hirata, Yoshiko Usui, Jun Shibasaki, Hideaki Ueda, Noriko Aida
PURPOSE: Mesenterico-left portal vein (meso-Rex) bypass is as an effective modality for restoring intrahepatic portal perfusion in patients with extrahepatic portal vein obstruction. Achieving sufficient patency is difficult with end-to-side anastomosis of a bypass graft to a small or hypoplastic left portal vein in the Rex recessus. Here, we describe the use of a recanalized umbilical vein in the round ligament as a conduit for bypass construction in two patients. METHODS: Case 1 was an 11-year-old boy diagnosed with rupture of the esophageal varices and hypersplenism due to congenital extrahepatic portal hypertension...
March 2011: Pediatric Surgery International
Christophe Chardot, Alexandre Darani, Remi Dubois, Pierre-Yves Mure, Jean-Pierre Pracros, Alain Lachaux
UNLABELLED: Meso-Rex shunt (MRS) can relieve portal hypertension and restore a physiological portal flow in patients with portal vein thrombosis. We describe a technical variant where the autologous internal jugular vein (IJV) was too short to bridge the superior mesenteric vein (SMV) and the Rex recessus. PATIENT: A 15-year-old boy with portal cavernoma had several episodes of gastrointestinal bleeding despite repeated sclerotherapy. Preoperative assessment, including retrograde transjugular portography, showed persistent esophageal and gastric varices, severe hypertensive gastropathy, obstructed portal vein, patent SMV and splenomesenteric confluence, patent intrahepatic portal branches, and normal transhepatic pressure gradient...
November 2009: Journal of Pediatric Surgery
Xiao-Hui Lv, Hong-Bo Liu, Ying Wang, Bing-Yuan Wang, Min Song, Ming-Jun Sun
AIM: To evaluate the prognostic ability of model for end-stage liver disease (MELD) to serum sodium (SNa) ratio (MESO) index and to compare the predictive accuracy of the MESO index with the MELD score and the modified Child-Turcotte-Pugh (CTP) score for short-term survival in cirrhotic patients. METHODS: A total of 256 patients with cirrhosis were retrospectively evaluated. The predictive accuracy of the MESO index, MELD score and modified CTP score were compared by the area under the receiver-operator characteristic curve (AUC)...
September 2009: Journal of Gastroenterology and Hepatology
Ye Htun Oo, Simon Olliff, Geoffrey Haydon, Douglas Thorburn
BACKGROUND AND METHODS: Biliary obstruction as a consequence of portal biliopathy, because of extrahepatic portal vein occlusion is an uncommon cause of biliary disease in the western world. We reviewed all patients presenting to the Regional Liver Transplant Unit in Birmingham, UK with symptomatic portal biliopathy between 1992 and 2005 and report the presentation, investigation, management and outcome of these complex patients. RESULTS: Thirteen patients with symptomatic portal biliopathy were followed up for a median of 2 years (range 1-18 years)...
February 2009: European Journal of Gastroenterology & Hepatology
Kenji Takasaki, Hiroshi Umeki, Kaori Enatsu, Fujinobu Tanaka, Noriyuki Sakihama, Hidetaka Kumagami, Haruo Takahashi
OBJECTIVES/HYPOTHESIS: This study aimed to demonstrate the feasibility of a novel high-resolution manometry system, and to establish normal values of swallowing pressures along the velopharynx and upper esophagus. STUDY DESIGN: Prospective study. METHODS: Thirty-three asymptomatic adult Japanese controls were studied. A solid-state high-resolution manometry assembly with 36 circumferential sensors spaced 1 cm apart was positioned to record pressures during swallowing from the velopharynx to the upper esophagus...
October 2008: Laryngoscope
Shi Weimin, Zhang Gen, Dai Guifu, Zhang Yunxiao, Zhao Jin, Tao Jingchao
The synthesis of a series of modularized porphyrins bearing bioactive molecule is described. Starting with meso-tetraphenylporphyrin, the compounds with two nitro functional groups were synthesized via regiospecific nitration reaction. After reduction to the amino group and subsequent coupling with l-phenylalanine or 1-carboxylmethyl-5-fluorouracil (5-Fu acid), the functionalized porphyrins were metallized with Co(II) or Mn(II) to form miscellaneous porphyrins in good yields. The spectra of all the porphyrins were furnished...
May 15, 2008: Bioorganic & Medicinal Chemistry
Bill Chiu, Srikumar B Pillai, Anthony D Sandler, Riccardo A Superina
The meso-Rex bypass procedure has been used to treat patients with portal hypertension from extrahepatic portal vein obstruction. This report describes modifications of this procedure in 5 patients. Either the splenic or coronary vein was used as the venous inflow point, and the bypass was performed either directly through transposition of the vein or with the use of a venous conduit.
July 2007: Journal of Pediatric Surgery
Akiko Uehara, Yukari Fujimoto, Koichi Fukase, Haruhiko Takada
Epithelial cells may form the first barrier of defense against bacteria in human tissues. We recently revealed that oral epithelial cells generated anti-bacterial factors, such as peptidoglycan recognition proteins (PGRPs) and beta-defensin 2, but not proinflammatory cytokines, such as interleukin-8 (IL-8), upon stimulation with bacterial cell-surface components. In this study, we found clear expressions of Toll-like receptor (TLR)2, TLR3, TLR4, TLR7, NOD1 and NOD2 in oral, tongue, salivary gland, pharyngeal, esophageal, intestinal, cervical, breast, lung, and kidney epithelial cells...
May 2007: Molecular Immunology
Riccardo A Superina, Estella M Alonso
The treatment of portal hypertension in children has undergone considerable evolution in the past decade. The treatment offered depends on the cause of the hypertension and the underlying health of the liver. The diagnosis of portal hypertension often can be made by the history and physical examination. Upper gastrointestinal bleeding in the presence of splenic enlargement is pathognomonic for portal hypertension. Bleeding and hypersplenism are the principal symptoms. Treatment of bleeding starts with confirming the diagnosis with esophageal and gastric endoscopy...
September 2006: Current Treatment Options in Gastroenterology
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