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https://www.readbyqxmd.com/read/29792167/association-between-glaucoma-severity-and-driving-cessation-in-subjects-with-primary-open-angle-glaucoma
#1
Aya Takahashi, Kenya Yuki, Sachiko Awano-Tanabe, Takeshi Ono, Daisuke Shiba, Kazuo Tsubota
BACKGROUND: The aim of this study, which included a baseline cross-sectional study and a 3-year follow-up prospective study, was to investigate the association between glaucomatous visual field damage and driving cessation in subjects with primary open-angle glaucoma (POAG). METHODS: A total of 211 POAG subjects divided into 3 groups according to POAG severity (mild, moderate, or severe) in the better eye were enrolled along with 148 control subjects; subjects were asked about changes in their driving status...
May 23, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29789659/comparison-of-glaucoma-diagnostic-ability-between-wide-field-swept-source-oct-retinal-nerve-fiber-layer-maps-and-spectral-domain-oct
#2
Won June Lee, Sohee Oh, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To compare the diagnostic ability of wide-field swept-source optical coherence tomography (SS-OCT) retinal nerve fiber layer (RNFL) maps with spectral-domain OCT (SD-OCT) maps for detection of preperimetric (PPG) and early glaucoma (EG). PATIENTS AND METHODS: One hundred and forty-six eyes, including 37 healthy eyes, 38 eyes with PPG, and 71 eyes with EG, were analyzed. The patients underwent both SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) and wide-field SS-OCT scanning (DRI-OCT-1 Atlantis; Topcon, Tokyo, Japan)...
May 23, 2018: Eye
https://www.readbyqxmd.com/read/29788006/peripheral-microvascular-abnormalities-detected-by-wide-field-fluorescein-angiography-in-eyes-with-branch-retinal-vein-occlusion
#3
Yusuke Yasuda, Yoshio Hirano, Yuya Esaki, Taneto Tomiyasu, Norihiro Suzuki, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura
PURPOSE: To evaluate the location of microvascular abnormalities using wide-field fluorescein angiography (WFFA) and investigate the impact on visual outcome in eyes with branch retinal vein occlusion (BRVO). METHODS: Forty eyes of 39 patients (24 males and 15 females with an average age of 71 years) were retrospectively reviewed. One patient had BRVO bilaterally. WFFA was performed in all patients to evaluate perfusion status and detect microvascular abnormalities...
May 22, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29787492/dot-motion-perception-in-young-adult-emmetropes-and-myopes
#4
Hui-Ying Kuo, David A Atchison, Katrina Leanne Schmid
SIGNIFICANCE: Central motion perception, as assessed by minimum displacement detection, was reduced in highly myopic eyes. Peripheral motion detection may be influenced by myopia, particularly in the inferior-nasal retina. PURPOSE: Motion discrimination is a complex visual task processed mainly via the magnocellular pathway. We investigated whether it is affected in myopia. METHODS: Ninety young adults aged 18 to 28 years participated: 30 emmetropes (spherical equivalent refractions +1...
May 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29787487/case-report-hydroxychloroquine-retinopathy
#5
Mohab Eldeeb, Errol W Chan, Amer Omar
SIGNIFICANCE: Hydroxychloroquine retinopathy causes irreversible central visual loss and can progress despite medication discontinuation. Appropriate dosing and recognition of early disease are important to minimize adverse visual sequelae. In 2016, the American Academy of Ophthalmology updated its 2011 recommendations for dosing, screening, and monitoring of hydroxychloroquine retinopathy. PURPOSE: The aim of this study was to report a case of hydroxychloroquine retinopathy in a patient who developed toxicity on a dose meeting safety thresholds from the 2011 guidelines (i...
May 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29785987/variant-myopia-a-new-presentation
#6
Jameel Rizwana Hussaindeen, Mithra Anand, Viswanathan Sivaraman, Krishna Kumar Ramani, Peter M Allen
Purpose: Variant myopia (VM) presents as a discrepancy of >1 diopter (D) between subjective and objective refraction, without the presence of any accommodative dysfunction. The purpose of this study is to create a clinical profile of VM. Methods: Fourteen eyes of 12 VM patients who had a discrepancy of >1D between retinoscopy and subjective acceptance under both cycloplegic and noncycloplegic conditions were included in the study. Fourteen eyes of 14 age- and refractive error-matched participants served as controls...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29784158/fixation-parameter-test-retest-repeatability-of-the-worse-eye-in-central-field-loss
#7
Saba Samet, Luminita Tarita-Nistor, Esther G González, Mark S Mandelcorn, Efrem D Mandelcorn, Martin J Steinbach
OBJECTIVE: Patients with bilateral central field loss develop peripheral retinal loci (PRLs) in the functional eccentric retina. PRL characteristics and visual performance in the better-seeing eye (BE) of these patients have previously been reported. In this study, we determined the test-retest repeatability of fixation parameters, including fixation stability, PRL eccentricity, and PRL span in the worse-seeing eye (WE). DESIGN: Retrospective consecutive case series...
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29784153/perifoveal-capillary-network-quantification-in-young-diabetic-patients-with-subclinical-or-no-retinopathy
#8
Zoi Kapsala, Aristofanis Pallikaris, Dimitrios Mamoulakis, Joanna Moschandreas, Georgios Bontzos, Miltiadis Tsilimbaris
OBJECTIVE: To assess the morphology of perifoveal capillary network with quantitative parameters in young patients with diabetes mellitus type I (DM I) using an algorithm. METHODS: Fifty-three images (33 eyes of 33 DM I patients and 20 eyes of 20 non-DM controls) were chosen retrospectively from the University Hospital of Heraklion digital fluorescein angiography database. An additional group consisting of patients with advanced DR abnormalities was included in our analysis to investigate whether our method detects alterations when they are present...
June 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29782944/a-comprehensive-review-on-contact-lens-for-ophthalmic-drug-delivery
#9
REVIEW
Jiawen Xu, Yingyan Xue, Gaoyong Hu, Tianyu Lin, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tang
With the prevalence of electronic devices and an aging population, the number of people affected with eye disease is increasing year by year. In spite of a large number of eye drops on the market, most of them do not perform sufficiently, due to rapid clearance mechanisms and ocular barriers. To enhance drug delivery to the eye, a number of novel formulations for ocular diseases have been investigated over recent decades, aiming to increase drug retention and permeation while also allowing for sustained drug release over prolonged periods...
May 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29782814/primary-assessment-of-the-patient-with-orbital-fractures-should-include-pupillary-response-and-visual-acuity-changes-to-detect-occult-major-ocular-injuries
#10
Jeffrey Chow, Krishnan Parthasarathi, Patrick Mehanna, Eline Whist
PURPOSE: Sight-threatening injuries associated with orbital fractures are of major concern to maxillofacial surgeons whom are often the first asked to assess these patients. Eliciting signs and symptoms that are predictive of these injuries would allow expedited ophthalmic consultation and appropriate management. We hypothesized that abnormal pupillary response is predictive of major ocular injuries. PATIENTS AND METHODS: A retrospective cohort study of patients with facial fractures was instituted with review of all associated ophthalmic injuries...
May 1, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29781873/case-report-use-of-sports-and-performance-vision-training-to-benefit-a-low-vision-patient-s-function
#11
Daniel M Laby
SIGNIFICANCE: Despite our inability to attenuate the course of many ocular diseases that can ultimately lead to loss or significantly decreased visual function, this report describes a potential technique to aid such patients in maximizing the use of the vision that remains. PURPOSE: The aim of this study was to demonstrate the applicability of utilizing sports vision training to improve objective and subjective visuomotor function in a low-vision patient. CASE REPORT: A 37-year-old woman with Usher syndrome presented with reduced central visual acuity and visual field...
May 17, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29781835/deep-learning-classifier-with-an-ultra-wide-field-scanning-laser-ophthalmoscope-detects-glaucoma-visual-field-severity
#12
Masumoto Hiroki, Hitoshi Tabuchi, Shunsuke Nakakura, Ishitobi Naofumi, Masayuki Miki, Enno Hiroki
PURPOSE: To evaluate the accuracy of detecting glaucoma visual field defect severity using deep-learning classifier (DL) with an ultra-wide-field scanning laser ophthalmoscope. METHODS: One eye of 982 open angle glaucoma (OAG) patients and 417 healthy eyes were enrolled. We categorized glaucoma patients into three groups according to the glaucoma visual field damage (Humphrey Field Analyzer 24-2 program) (early; -6▒dB (mean deviation) or better, moderate; between -6 and -12▒dB, and severe as mean deviation of -12▒dB or worse)...
May 17, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29780940/colored-floaters-as-a-manifestation-of-digoxin-toxicity
#13
Lynn Shi, Linus D Sun, Jeffrey G Odel
Purpose: Since its report in one patient more than 70 years ago, digitalis-induced colored muscae volitantes have not surfaced again in the literature. We report here a case of digoxin induced colored floaters. Observations: An 89-year-old man on 0.25 mg digoxin daily developed visual hallucinations and colored floaters. He had floaters in the past but now they were in various colors including yellow, green, blue and red, though predominantly in yellow. These "weirdly" shaped little particles wiggled around as if in a viscous solution and casted shadows in his vision...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780917/advanced-pigment-dispersion-glaucoma-secondary-to-phakic-intraocular-collamer-lens-implant
#14
Clara Ye, Cajal K Patel, Anna C Momont, Yao Liu
Purpose: We report a case of pigment dispersion glaucoma secondary to uncomplicated phakic intraocular collamer lens (ICL) (Visian ICL™, Staar Inc., Monrovia, CA) implant that resulted in advanced visual field loss. Observations: A 50-year-old man presented for routine follow-up status post bilateral phakic intraocular collamer lens (ICL) placement 8 years earlier. He was incidentally found to have a decline in visual acuity from an anterior subcapsular cataract and elevated intraocular pressure (IOP) in the left eye...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29779933/-hereditary-optic-neuropathies-in-pediatric-ophthalmology
#15
C Orssaud, M P Robert, D Bremond Gignac
INTRODUCTION: Hereditary optic neuropathies (HON) often begin in adulthood. However, some of them can have an early onset. These may have specific clinical features and natural histories. PATIENTS AND METHODS: Retrospective study of HON patients with onset before the age of 14 years seen in a referral center. In addition to the age of onset, we evaluated the genetic etiology, visual acuity at 15 years, last best corrected visual acuity, optic disc appearance, visual field and extra-ophthalmological manifestations...
May 17, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29779685/the-relationship-of-retinal-vessel-geometric-characteristics-to-the-incidence-and-progression-of-diabetic-retinopathy
#16
Ronald Klein, Kristine E Lee, Lorraine Danforth, Michael Y Tsai, Ronald E Gangnon, Stacy E Meuer, Tien Y Wong, Carol Y Cheung, Barbara E K Klein
PURPOSE: To examine the relationships of retinal vessel geometric characteristics (RVGCs) to the incidence and progression of diabetic retinopathy (DR). DESIGN: Observational, prospective cohort study. PARTICIPANTS: Nine hundred ninety-six persons with type 1 diabetes mellitus (T1DM) and 1370 persons with type 2 diabetes mellitus (T2DM) seen at a baseline examination who were eligible for follow-up examinations at subsequent 5-year intervals...
May 17, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29777757/stem-cell-based-retina-models
#17
Kevin Achberger, Jasmin C Haderspeck, Alexander Kleger, Stefan Liebau
From the early days of cell biological research, the eye-especially the retina-has evoked broad interest among scientists. The retina has since been thoroughly investigated and numerous models have been exploited to shed light on its development, morphology, and function. Apart from various animal models and human clinical and anatomical research, stem cell-based models of animal and human cells of origin have entered the field, especially during the last decade. Despite the observation that the retina of different species comprises endogenous stem cells, most stem cell-related research in the human retina is now based on pluripotent stem cell models...
May 16, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29777044/the-impact-of-sign-glaucoma-guidelines-on-false-positive-referrals-from-community-optometrists-in-central-scotland
#18
Samantha Sii, Ahmad Nasser, Cheng Yi Loo, Catherine Croghan, Alan Rotchford, Pankaj Kumar Agarwal
BACKGROUND: Since the introduction of National Institute for Health and Care Excellence glaucoma guidelines 2009, the number of referrals from community optometrists to hospital eye services has increased across the UK, resulting in increase in first visit discharge rates (FVDRs). AIM: To assess the impact of Scottish Intercollegiate Guidelines Network (SIGN) 144 on quality of referrals from community optometrists. METHODOLOGY: A retrospective study of patient records who attended as new adult glaucoma referrals to clinics in Princess Alexandra Eye Pavilion, Edinburgh, and in Greater Glasgow and Clyde, was carried out across October-November 2014 (group 1) and September-October 2016 (group 2), before and after the introduction of SIGN 144...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29775702/abnormal-sleep-architecture-and-hippocampal-circuit-dysfunction-in-a-mouse-model-of-fragile-x-syndrome
#19
Christine E Boone, Heydar Davoudi, Jon B Harrold, David J Foster
Fragile X syndrome (FXS) is the most common heritable cause of intellectual disability and single-gene cause of autism spectrum disorder. The Fmr1 null mouse models much of the human disease including hyperarousal, sensory hypersensitivity, seizure activity, and hippocampus-dependent cognitive impairment. Sleep architecture is disorganized in FXS patients, but has not been examined in Fmr1 knockout (Fmr1-KO) mice. Hippocampal neural activity during sleep, which is implicated in memory processing, also remains uninvestigated in Fmr1-KO mice...
May 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29771887/-new-visual-field-testing-possibilities-a-preliminary-report
#20
V P Erichev, A P Ermolaev, A A Antonov, G L Grigoryan, D V Kosova
There are currently no portable mobile perimeters that allow visual field testing outside ophthalmologist's examination rooms. PURPOSE: To develop a mobile perimetry technique based on use of a virtual reality headset (VR). MATERIAL AND METHODS: The study involved 26 patients (30 eyes) with II-III stage primary open-angle glaucoma (POAG) with compensated IOP. Perimetry was performed for each patient twice - on Humphrey analyzer (test 30-2, 76 points) and employing similar strategy on a perimeter integrated into VR headset (Total Vision, Russia)...
2018: Vestnik Oftalmologii
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