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https://www.readbyqxmd.com/read/29154519/current-treatments-for-anal-condylomata-acuminata
#1
Massimiliano Mistrangelo, Ivano Dal Conte, Silvio Volpatto, Giulio DI Benedetto, Valentina Testa, Francesca Currado, Mario Morino
INTRODUCTION: Condylomata acuminate are the most common sexually transmitted disease worldwide. They are usually a serious problem, but it causes emotional distress to patient and physician alike because of its marked tendency to recurrence. The presence of anogenital warts mandates treatment, also for potential degeneration of the lesions. EVIDENCE ACQUISITION: A review of the Literature has been performed to analyze proposed treatments for anogenital warts. EVIDENCE SYNTHESIS: Many treatments have been employed...
November 20, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29149399/overcoming-hiv-stigma-a-qualitative-analysis-of-hiv-cure-research-and-stigma-among-men-who-have-sex-with-men-living-with-hiv
#2
Feng Wu, Alice Zhang, Andrew Babbitt, Qingyan Ma, Nir Eyal, Xin Pan, Weiping Cai, Fengyu Hu, Yu Cheng, Joseph D Tucker
Despite global progress in HIV stigma reduction, persistent HIV stigma thwarts effective HIV service delivery. Advances in HIV biomedical research toward a cure may shift perceptions of people living with HIV and HIV stigma. The purpose of this study was to examine how men who have sex with men (MSM) living with HIV in Guangzhou, China perceive HIV cure research and its potential impact on MSM and HIV stigma. We conducted in-depth interviews with 26 MSM living with HIV about their perceptions of HIV cure research and the potential impact of an HIV cure on their lives...
November 17, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29146122/health-and-wellbeing-of-indigenous-adolescents-in-australia-a-systematic-synthesis-of-population-data
#3
Peter S Azzopardi, Susan M Sawyer, John B Carlin, Louisa Degenhardt, Ngiare Brown, Alex D Brown, George C Patton
BACKGROUND: Indigenous populations have high rates of disease and premature mortality. Most Indigenous communities are young, and adolescence (age 10-24 years) provides great opportunities for population health gain. However, the absence of a comprehensive account of Indigenous adolescents' health has been a barrier to effective policy. We aimed to report a national health profile for Indigenous adolescents in Australia. METHODS: We undertook a systematic synthesis of population data to report the health and wellbeing of Indigenous adolescents in Australia...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29142204/sociospatial-structure-explains-marked-variation-in-brucellosis-seroprevalence-in-an-alpine-ibex-population
#4
Pascal Marchand, Pauline Freycon, Jean-Philippe Herbaux, Yvette Game, Carole Toïgo, Emmanuelle Gilot-Fromont, Sophie Rossi, Jean Hars
In a context of (re)emerging infectious diseases with wildlife reservoirs, understanding how animal ecology shapes epidemiology is a key issue, particularly in wild ungulates that share pathogens with domestic herbivores and have similar food requirements. For the first time in Europe, brucellosis (Brucella melitensis), a virulent zoonosis, persisted in an Alpine ibex (Capra ibex) population and was transmitted to cattle and humans. To better understand disease dynamics, we investigated the relationships between the spatial ecology of ibex and the epidemiology of brucellosis...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29139352/-contraception-for-young-women-with-focus-on-long-acting-reversible-contraceptives
#5
EDITORIAL
Pernille Ravn, Kresten Rubeck Petersen
Long-acting, reversible contraceptives are about 20 times more effective in terms of contraceptive efficacy than oral hormonal contraceptives, patch or vaginal ring are. Long-acting, reversible contraceptives are not associated with serious adverse events but induce changes in menstrual bleeding pattern in about 75% of the users. The progestogen intrauterine device is effective in the treatment of menor-rhagia and dysmenorrhoea. Increased use of long-acting reversible contraceptives is expected to reduce unplanned pregnancies and legal abortions in all ages...
November 13, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29136021/saturation-effects-and-the-concurrency-hypothesis-insights-from-an-analytic-model
#6
Joel C Miller, Anja C Slim
Sexual partnerships that overlap in time (concurrent relationships) may play a significant role in the HIV epidemic, but the precise effect is unclear. We derive edge-based compartmental models of disease spread in idealized dynamic populations with and without concurrency to allow for an investigation of its effects. Our models assume that partnerships change in time and individuals enter and leave the at-risk population. Infected individuals transmit at a constant per-partnership rate to their susceptible partners...
2017: PloS One
https://www.readbyqxmd.com/read/29135519/syphilis-of-the-aerodigestive-tract
#7
Julie Y Tse, May P Chan, Judith A Ferry, Vikram Deshpande, Aliyah R Sohani, Valentina Nardi, Andras Schaffer, Rosalynn M Nazarian, Lawrence R Zukerberg
Syphilis, a sexually transmitted infection caused by the Gram-negative bacterium Treponema pallidum, is increasing in prevalence in the United States. It has been our experience that primary and secondary syphilis of the aerodigestive tract can afflict a large age spectrum with varied clinical and histopathologic findings, which can lead to diagnostic problems and frequent misdiagnosis. In this study, we describe the histopathologic patterns of syphilis of the aerodigestive tract to expand awareness of its varied appearance...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29132441/early-screening-for-chlamydia-trachomatis-in-young-women-for-primary-prevention-of-pelvic-inflammatory-disease-i-predict-study-protocol-for-a-randomised-controlled-trial
#8
Jeanne Tamarelle, Anne C M Thiébaut, Bénédicte Sabin, Cécile Bébéar, Philippe Judlin, Arnaud Fauconnier, Delphine Rahib, Layidé Méaude-Roufai, Jacques Ravel, Servaas A Morré, Bertille de Barbeyrac, Elisabeth Delarocque-Astagneau
BACKGROUND: Genital infection with Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection, especially among young women. Mostly asymptomatic, it can lead, if untreated, to pelvic inflammatory disease (PID), tubal factor infertility and ectopic pregnancy. Recent data suggest that Ct infections are not controlled in France and in Europe. The effectiveness of a systematic strategy for Ct screening in under-25 women remains controversial. The main objective of the i-Predict trial (Prevention of Diseases Induced by Chlamydia trachomatis) is to determine whether early screening and treatment of 18- to-24-year-old women for genital Ct infection reduces the incidence of PID over 24 months...
November 13, 2017: Trials
https://www.readbyqxmd.com/read/29128296/sexual-and-reproductive-health-care-receipt-among-young-males-aged-15-24
#9
Arik V Marcell, Susannah E Gibbs, Nanlesta A Pilgrim, Kathleen R Page, Renata Arrington-Sanders, Jacky M Jennings, Penny S Loosier, Patricia J Dittus
PURPOSE: This study aimed to describe young men's sexual and reproductive health care (SRHC) receipt by sexual behavior and factors associated with greater SRHC receipt. METHODS: There were 427 male patients aged 15-24 who were recruited from 3 primary care and 2 sexually transmitted disease (STD) clinics in 1 urban city. Immediately after the visit, the survey assessed receipt of 18 recommended SRHC services across four domains: screening history (sexual health, STD/HIV test, family planning); laboratories (STDs/HIV); condom products (condoms/lubrication); and counseling (STD/HIV risk reduction, family planning, condoms); in addition, demographic, sexual behavior, and visit characteristics were examined...
November 8, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29128125/-diagnostic-issues-of-lymphogranuloma-venereum-a-case-series-of-5%C3%A2-patients
#10
A Fabre-Baudouin, A L Roux, C Marin, M Lachatre, M De Laroche, M Ponsoye, T Hanslik, S Trad
INTRODUCTION: Lymphogranuloma venereum (LG) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis L serovar. METHODS: These five consecutive cases aim to highlight the risk of LG misdiagnosis, in case of initial presentation with isolated inguinal adenitis. RESULTS: Five men (mean age: 30±7 years) were seen in an internal medicine department, for inguinal adenopathy. One patient had clinical signs of urethritis. None presented an associated rectitis...
November 8, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29125715/two-phase-1-open-label-single-dose-randomized-crossover-studies-to-assess-the-pharmacokinetics-safety-and-tolerability-of-orally-administered-granules-of-secnidazole-2-g-in-healthy-female-volunteers-under-different-administration-conditions
#11
Helen S Pentikis, Nikki Adetoro
Bacterial vaginosis (BV) is the most common vaginal infection in reproductive-age women and a significant risk factor for sexually transmitted diseases and pregnancy complications. Standard 5- to 7-day antimicrobial treatments for BV are associated with high rates of recurrence and adverse events. SYM-1219 is a novel granule formulation containing 2 g of secnidazole, developed as an oral, single-dose BV treatment. Two phase 1, open-label, single-center, randomized, crossover trials (studies 102 and 103) assessed the pharmacokinetics and safety of SYM-1219 single doses (≥7-day washout between doses) in healthy, nonpregnant women aged 18 to 65 years inclusive...
November 10, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29124332/sexually-transmitted-infections-of-the-lower-gastrointestinal-tract
#12
Rahul Jawale, Keith K Lai, Laura W Lamps
The World Health Organization estimates that there is greater than one million new cases of sexually transmitted infections (STIs) every day. In many countries, STIs are at an unprecedented high, including the USA, where nearly 20 million new cases were reported in 2016. Although morbidity associated with STIs is usually seen in the context of genitourinary disease, these pathogens may also affect the gastrointestinal tract and cause anal pain, abdominal pain, or diarrhea. It is important to recognize patterns of injury associated with these pathogens, especially those that may mimic other gastrointestinal diseases, such as idiopathic inflammatory bowel disease (IBD)...
November 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29122384/strengthening-global-vaccine-access-for-adolescents-and-adults
#13
REVIEW
Angeline Nanni, Stefanie Meredith, Stephanie Gati, Karin Holm, Tom Harmon, Ann Ginsberg
Global immunization efforts to date have heavily focused on infants and children, with noted success on public health. Healthy adolescents and adults contribute to the economic growth and development of countries but efforts to ensure vaccine coverage for these groups receive inadequate global attention and resources. Emerging epidemics for a number of infectious diseases including Ebola, Zika, dengue, malaria and the continuing epidemics of tuberculosis and several sexually transmitted infections, including HIV, HPV and Hepatitis B, have high incidence and prevalence in adolescents and adults...
November 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29118826/prevalence-of-hpv-infection-in-hypopharyngeal-and-laryngeal-squamous-cell-carcinoma-at-thailand-s-largest-tertiary-referral-center
#14
Warut Pongsapich, Nitathip Eakkasem, Sontana Siritantikorn, Paveena Pithuksurachai, Kshidej Bongsabhikul, Cheerasook Chongkolwatana
Background: Following the well-established relationship between human papillomavirus (HPV) and cervical carcinoma, the carcinogenicity of this virus has also been confirmed in subsets of head and neck carcinoma (HNCA), but mainly in the oropharynx. Other subsites of HNCA with less known association to HPV have never been studied in Thailand. Accordingly, the aim of this study was to investigate the prevalence of HPV DNA in hypopharyngeal and laryngeal squamous cell carcinoma in Thai population...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29117636/chlamydia-trachomatis-regulates-growth-and-development-in-response-to-host-cell-fatty-acid-availability-in-the-absence-of-lipid-droplets
#15
Manu Sharma, Maria A Recuero-Checa, Francis Yue Fan, Deborah Dean
Chlamydia trachomatis (Ct) is a Gram-negative obligate intracellular pathogen of humans that causes significant morbidity from sexually transmitted and ocular diseases globally. Ct acquires host fatty acids (FA) to meet the metabolic and growth requirements of the organism. Lipid droplets (LDs) are storehouses of FAs in host cells and have been proposed to be a source of FAs for the parasitophorous vacuole, termed inclusion, in which Ct replicates. Previously, cells devoid of LDs were shown to produce reduced infectious progeny at 24 hours post-infection (hpi)...
November 8, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29114138/anti-trichomonas-vaginalis-activity-of-nano-micana-cordifolia-and-metronidazole-an-in-vitro-study
#16
Hossein Vazini
Trichomonas vaginalis is a flagellate parasite living in the genital tract and it is accounted as a sexually transmitted disease. The clinical symptoms vary from the asymptomatic to the severe form which is usually associated with the irritation, itching and infertility in some severe cases. Many drugs have been applied to treat this disease and Metronidazole is the gold standard for treatment; however, it has also detected that this medicine has many side-effects which it has been motivated the researchers to find an appropriate alternative for this medicine...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29102554/structural-intervention-with-school-nurses-increases-receipt-of-sexual-health-care-among-male-high-school-students
#17
Patricia J Dittus, Christopher R Harper, Jeffrey S Becasen, Robin A Donatello, Kathleen A Ethier
PURPOSE: Adolescent males are less likely to receive health care and have lower levels of sexual and reproductive health (SRH) knowledge than adolescent females. The purpose of this study was to determine if a school-based structural intervention focused on school nurses increases receipt of condoms and SRH information among male students. METHODS: Interventions to improve student access to sexual and reproductive health care were implemented in six urban high schools with a matched set of comparison schools...
November 2, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29100527/hpv11-e6-mutation-by-overexpression-of-apobec3a-and-effects-of-interferon-%C3%AF-on-apobec3s-and-hpv11-e6-expression-in-hpv11-hacat-cells
#18
Yongfang Wang, Xinyu Li, Shasha Song, Yang Sun, Jiafen Zhang, Changming Yu, Wei Chen
BACKGROUND: Condyloma acuminatum, infected by low-risk human papillomaviruses (e.g., HPV6 and HPV11), is one of the most widespread sexually transmitted diseases. Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 proteins (APOBEC3s, A3s) are cellular cytidine deaminases acting as antiviral factors through hypermutation of viral genome. However, it remains unknown whether A3s results in HPV11 gene mutations and interferon-ω (IFN-ω) exhibits antiviral activities through the A3s system...
November 3, 2017: Virology Journal
https://www.readbyqxmd.com/read/29099372/rare-isolated-oral-manifestations-of-secondary-syphilis-in-an-adolescent
#19
Cínthia M Ribeiro, Marina L de Carli, Felipe F Sperandio, Evandro M S Magalhães, João Adolfo C Hanemann
Syphilis is a sexually transmitted infection caused by Treponema pallidum. The disease can manifest clinically through 3 different stages: primary, secondary, and tertiary. This report describes an uncommon case of secondary syphilis in a 16-year-old boy who showed only oral clinical manifestations. The infection was diagnosed through serologic tests. Treatment with intramuscular benzathine penicillin G led to complete remission of the oral lesions 3 weeks after initiation of treatment. The current case demonstrates the importance of laboratory tests in establishing an accurate diagnosis of syphilis and thereby avoiding unnecessary biopsies...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29099104/la-salud-durante-el-cardenismo-1934-1940
#20
Martha Eugenia Rodríguez
The present symposium, Health during the Cardenismo (1934-1940), consist of four studies: Medical sanitary aspects in Mexico by Martha Eugenia Rodríguez; Campaigns against diseases by Carlos Viesca Treviño; Hospitals during Cardenism by Guillermo Fajardo Ortiz; and Military medicine in Mexico by Antonio Moreno Guzmán. Through them is given an integral vision of the state of health and illness during the administration of General Lázaro Cárdenas del Río, the first sexennial presidential government of the twentieth century...
2017: Gaceta Médica de México
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