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https://www.readbyqxmd.com/read/27932675/the-effects-of-voluntary-exercise-and-prazosin-on-capillary-rarefaction-and-metabolism-in-streptozotocin-induced-diabetic-male-rats
#1
Emily C Dunford, Erwan Leclair, Julian Aiken, Erin R Mandel, Tara L Haas, Olivier Birot, Michael C Riddell
Type-1 diabetes mellitus (T1D) causes impairments within the skeletal muscle microvasculature. Both regular exercise and prazosin have been shown to improve skeletal muscle capillarization and metabolism in healthy rats, through distinct angiogenic mechanisms. The aim of this study was to evaluate the independent and additive effects of voluntary exercise and prazosin treatment on capillary-to-fiber ratio (C:F) in streptozotocin (STZ)-treated diabetic rats. STZ (65mg/kg) was intraperitoneally administered to male Sprague-Dawley rats (n=36) to induce diabetes, with healthy, non-diabetic, sedentary rats (n=10) as controls...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27931580/changes-in-muscle-strength-and-six-minute-walk-distance-before-and-after-living-donor-liver-transplantation
#2
Y Mizuno, S Ito, K Hattori, M Nagaya, T Inoue, Y Nishida, Y Onishi, H Kamei, N Kurata, Y Hasegawa, Y Ogura
BACKGROUND: Impaired exercise capacity and muscle weakness are important characteristics of liver transplantation recipients. Perioperative rehabilitation has been introduced to promote early mobilization of patients and to prevent postoperative pulmonary complications. However, it is unknown how physical status recovers during the hospital stay after a liver transplant. The purpose of this study was to evaluate the changes in clinical indicators that represent the functional exercise capacity and muscle strength before and after living donor liver transplantation (LDLT)...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27930451/postexercise-hypotension-is-volume-dependent-in-hypertensives-autonomic-and-forearm-blood-responses
#3
Aline de Freitas Brito, Maria do Socorro Brasileiro Santos, Caio Victor Coutinho de Oliveira, Amilton da Cruz Santos
The purpose of this study was to investigate the short-term effect of kettlebell swings (KBSs) on lumbopelvic pressure pain thresholds (PPTs) in healthy adults. Sixty participants (male=23, female=37, mean age=25.12 years ±2.86, height=170.73 cm ± 9.2, mass=70.49 kg ± 13.32) were randomized into one of two groups. The experimental group performed a warm-up followed by eight consecutive 20-second rounds of KBS with 10-second rest periods. The control group performed the warm-up alone. An evaluator blinded to group assignment, assessed PPTs immediately before and after the intervention using a handheld pressure algometer...
November 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27928217/effects-of-a-high-protein-and-omega-3-enriched-diet-with-or-without-creatine-supplementation-on-markers-of-soreness-and-inflammation-during-5-consecutive-days-of-high-volume-resistance-exercise-in-females
#4
Sara Hayward, Colin D Wilborn, Lem W Taylor, Stacie L Urbina, Jordan J Outlaw, Cliffa A Foster, Michael D Roberts
We examined if two different dietary interventions affected markers of soreness and inflammation over a 5-day high-volume resistance training protocol in females that resistance-trained 8 weeks prior. Twenty-eight females (age: 20 ± 1 yr; body mass: 63.5 ± 1.6 kg, height: 1.67 ± 0.01 m) completed 4 weeks of pre-training (weeks 1-4) followed by a subsequent 4-week training period along with a dietary intervention (weeks 5-8). Dietary interventions from weeks 5-8 included: a) no intervention (CTL, n = 10) b) a higher-protein diet supplemented with hydrolyzed whey protein (50 g/d) and omega-3 fatty acids (900 mg/d) (DI, n = 8), and c) the DI condition as well as creatine monohydrate (5 g/d) (DI+C, n = 10)...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27927595/decreased-cerebral-perfusion-in-duchenne-muscular-dystrophy-patients
#5
Nathalie Doorenweerd, Eve M Dumas, Eidrees Ghariq, Sophie Schmid, Chiara S M Straathof, Arno A W Roest, Beatrijs H Wokke, Erik W van Zwet, Andrew G Webb, Jos G M Hendriksen, Mark A van Buchem, Jan J G M Verschuuren, Iris Asllani, Erik H Niks, Matthias J P van Osch, Hermien E Kan
Duchenne muscular dystrophy is caused by dystrophin gene mutations which lead to the absence of the protein dystrophin. A significant proportion of patients suffer from learning and behavioural disabilities, in addition to muscle weakness. We have previously shown that these patients have a smaller total brain and grey matter volume, and altered white matter microstructure compared to healthy controls. Patients with more distal gene mutations, predicted to affect dystrophin isoforms Dp140 and Dp427, showed greater grey matter reduction...
October 17, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27925707/natural-mineral-bottled-waters-available-on-the-polish-market-as-a-source-of-minerals-for-the-consumers-part-2-the-intake-of-sodium-and-potassium
#6
Anna Gątarska, Joanna Ciborska, Elżbieta Tońska
Background: Natural mineral waters are purchased and consumed according to consumer preferences and possible recommendations. The choice of appropriate water should take into account not only the general level of mineralization but also the content of individual components, including electrolytes such as sodium and potassium. Sodium is necessary to ensure the proper physiological functions of the body. It is defined as a health risk factor only when its excessive intake occurs. Potassium acts antagonistically towards sodium and calcium ions, contributes to a reduction of the volume of extracellular fluids and at the same time reduces muscle tension and permeability of cell membranes...
2016: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/27923984/short-term-effect-of-volume-recruitment-derecruitment-manoeuvre-on-chest-wall-motion-in-duchenne-muscular-dystrophy
#7
Henri Meric, Line Falaize, Didier Pradon, Matthieu Lacombe, Michel Petitjean, David Orlikowski, Hélène Prigent, Frédéric Lofaso
Because progressive respiratory muscle weakness leads to decreased chest-wall motion with eventual ribcage stiffening, the purpose was to compare vital capacity (VC) and contributions of chest-wall compartments before and after volume recruitment-derecruitment manoeuvres (VRDM) in Duchenne muscular dystrophy (DMD). We studied nine patients with DMD and VC lower than 30% of predicted. VRDM was performed using 15 insufflations-exsufflations of +30 to -30 cmH2O. VC and three-dimensional chest-wall motion were measured, as well as oxygen saturation, transcutaneous partial pressure of carbon dioxide and the rapid shallow breathing index (respiratory rate/tidal volume) before (baseline) and immediately and 1 hour after VRDM...
December 6, 2016: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/27923982/effect-of-expiratory-positive-airway-pressure-on-tidal-volume-during-non-invasive-ventilation
#8
W Kinnear, L Watson, P Smith, L Johnson, S Burrows, J Colt, M Sovani, A Khanna
During non-invasive ventilation (NIV), tidal volume (V t) will depend upon the difference between inspiratory and expiratory positive airway pressure (IPAP and EPAP, respectively), provided the respiratory muscles are relaxed and the lungs and chest wall therefore move along their passive pressure-volume curves. To test this hypothesis, we studied the effect of increasing EPAP during pressure-controlled modes of NIV in 30 long-term ventilator users (10 each with scoliosis, obesity hypoventilation or neuromuscular disorders)...
December 6, 2016: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/27923622/factors-predicting-quadriceps-femoris-muscle-atrophy-during-the-first-12weeks-following-anterior-cruciate-ligament-reconstruction
#9
T Grapar Žargi, Matej Drobnič, Renata Vauhnik, Jadran Koder, Alan Kacin
BACKGROUND: Factors predicting quadriceps femoris muscle (QF) atrophy during the early period after arthroscopic ACL reconstruction have not been extensively studied. It is also yet to be confirmed whether muscle atrophy is a key determinant of postoperative QF weakness. METHODS: Mean changes in QF volume, MVIC torque and isometric endurance time were analysed in 25 patients prior to and at four and 12 weeks after surgery. A multivariable regression model of change in QF volume was made from combination of several parameters of preoperative QF size and strength and postoperative joint recovery...
December 3, 2016: Knee
https://www.readbyqxmd.com/read/27922742/the-diaphragm-acts-as-a-brake-during-expiration-to-prevent-lung-collapse
#10
Mariangela Pellegrini, Göran Hedenstierna, Agneta Roneus, Monica Segelsjö, Anders Larsson, Gaetano Perchiazzi
RATIONALE: The diaphragm is the major inspiratory muscle and is assumed to relax during expiration. However, electrical post-inspiratory activity has been observed. Whether or not there is an expiratory diaphragmatic contraction that preserves lung patency has yet to be explored. OBJECTIVE: We hypothesized the occurrence of an expiratory diaphragmatic contraction directed at stabilizing peripheral airways and preventing or reducing cyclic expiratory lung collapse...
December 6, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27922574/drop-body-syndrome-a-distinct-form-of-adult-spinal-deformity
#11
Mitsuru Yagi, Shinjiro Kaneko, Yoshiyuki Yato, Takashi Asazuma
STUDY DESIGN: A retrospective observational study. OBJECTIVE: This study examined the role of skeletal muscles in the spinal alignment of lumbar degenerative kyphosis (LDK). SUMMARY OF BACKGROUND DATA: Adult spinal deformity (ASD) may present as LDK, which is unusual in that it typically lacks any coronal deformity. METHODS: This retrospective study included 367 female ASD. Demographic and radiographic data from LDKs were compared with those with other ASD...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27919609/randomised-controlled-trial-potential-benefit-of-a-footplate-neuromuscular-electrical-stimulation-device-in-patients-with-chronic-venous-disease
#12
R Ravikumar, K J Williams, A Babber, T R A Lane, H M Moore, A H Davies
OBJECTIVES: Chronic venous disease (CVD) is common, affecting a quarter of the population. Current conservative methods of treatment aim to prevent progression of disease by reducing ambulatory venous pressure. Neuromuscular electrical stimulation (NMES) refers to the use of electrical impulses to elicit muscle contraction. This pilot randomised controlled trial investigates the effect of a footplate NMES device (REVITIVE) on venous flow parameters, limb oedema, and quality of life outcome measures in patients with CVD...
December 2, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27916370/tanshinone-iia-attenuates-epithelial-mesenchymal-transition-to-inhibit-the-tracheal-narrowing
#13
Hongtao Duan, Lijie Ma, Honggang Liu, Yong Zhang, Zhipei Zhang, Xiaolong Yan, Xiaofei Li
BACKGROUND: This study examines the effects of tanshinone IIA (TIIA) on epithelial-mesenchymal transition (EMT) in tracheal transplantation and the ability of TIIA to inhibit tracheal narrowing after tracheal transplantation. Mechanisms that may be involved in this process are also explored. METHODS: Human bronchial epithelial cells were treated in vitro with TGF-β1 for 72 h. The cells were pretreated with TIIA (40 μg/mL) or DMSO for 2 h before TGF-β1 stimulation...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27914791/aberrant-developmental-titin-splicing-and-dysregulated-sarcomere-length-in-thymosin-%C3%AE-4-knockout-mice
#14
Nicola Smart, Johannes Riegler, Cameron W Turtle, Craig A Lygate, Debra J McAndrew, Katja Gehmlich, Karina N Dubé, Anthony N Price, Vivek Muthurangu, Andrew M Taylor, Mark F Lythgoe, Charles Redwood, Paul R Riley
Sarcomere assembly is a highly orchestrated and dynamic process which adapts, during perinatal development, to accommodate growth of the heart. Sarcomeric components, including titin, undergo an isoform transition to adjust ventricular filling. Many sarcomeric genes have been implicated in congenital cardiomyopathies, such that understanding developmental sarcomere transitions will inform the aetiology and treatment. We sought to determine whether Thymosin β4 (Tβ4), a peptide that regulates the availability of actin monomers for polymerization in non-muscle cells, plays a role in sarcomere assembly during cardiac morphogenesis and influences adult cardiac function...
November 30, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27913423/bronchodilatory-effect-of-deep-inspiration-in-freshly-isolated-sheep-lungs
#15
William D Wong, Lu Wang, Peter D Paré, Chun Y Seow
Taking a big breath is known to reverse bronchoconstriction induced by bronchochallenge in healthy subjects; this bronchodilatory effect of deep inspiration (DI) is diminished in asthmatics. The mechanism underlying the DI effect is not clear. Observations from experiments using isolated airway smooth muscle (ASM) preparations and airway segments suggest that straining of ASM due to DI could lead to bronchodilation, possibly due to strain-induced reduction in ASM contractility. However, factors external to the lung cannot be excluded as potential causes for the DI effect...
December 2, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27912964/a-systematic-review-and-meta-analysis-of-the-herbal-formula-buzhong-yiqi-tang-for-stable-chronic-obstructive-pulmonary-disease
#16
REVIEW
Yuanbin Chen, Johannah Linda Shergis, Lei Wu, Xuhua Yu, Qigang Zeng, Yinji Xu, Xinfeng Guo, Anthony Lin Zhang, Charlie Changli Xue, Lin Lin
OBJECTIVE: To systematically evaluate the efficacy and safety of Buzhong Yiqi Tang (BZYQT) for stable chronic obstructive pulmonary disease (COPD). METHODS: Three electronic English databases (PubMed, EMBASE and CENTRAL) and four Chinese databases (CBM, CNKI, CQVIP and WFMO) were searched from their inceptions until 30th June 2016. Participants were diagnosed with COPD according to the Chinese Medical Association's COPD diagnosis and treatment guidelines or Global Initiative for Chronic Obstructive Lung Disease (GOLD), and were in stable stage...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27912770/endometriosis-associated-clear-cell-carcinoma-arising-in-caesarean-section-scar-a-case-report-and-review-of-the-literature
#17
Gabriella Ferrandina, Eleonora Palluzzi, Francesco Fanfani, Stefano Gentileschi, Anna Lia Valentini, Maria Vittoria Mattoli, Ilaria Pennacchia, Giovanni Scambia, Gianfranco Zannoni
BACKGROUND: Malignant transformation has been reported in approximately 1% of the endometriosis cases; herein, we report a case of clear cell endometrial carcinoma arising from endometriosis foci located within a caesarean section scar. CASE PRESENTATION: In November 2014, a Caucasian, 44-year-old woman was transferred to our institution because of severe respiratory failure due to massive lung embolism and rapid enlargement of a subcutaneous suprapubic mass. Abdomino-pelvic magnetic resonance showed a 10...
December 3, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27912153/overground-vs-treadmill-walking-on-biomechanical-energy-harvesting-an-energetics-and-emg-study
#18
Jean-Paul Martin, Qingguo Li
A biomechanical energy harvester is a wearable device that generates electricity from human motion. Walking on a treadmill has been used almost exclusively by researchers for studying the energetic effects of biomechanical energy harvesters and wearable robotics. A treadmill provides the advantage of having long duration trials within a stationary motion capture volume. However, no consensus exists on whether the results from treadmill walking accurately represent overground walking. We aim to investigate how a biomechanical energy harvester performs overground compared to on a treadmill by measuring energy expenditure and muscle activity...
November 19, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27911784/%C3%AE-arrestin-mediates-the-frank-starling-mechanism-of-cardiac-contractility
#19
Dennis M Abraham, Robert T Davis, Chad M Warren, Lan Mao, Beata M Wolska, R John Solaro, Howard A Rockman
The Frank-Starling law of the heart is a physiological phenomenon that describes an intrinsic property of heart muscle in which increased cardiac filling leads to enhanced cardiac contractility. Identified more than a century ago, the Frank-Starling relationship is currently known to involve length-dependent enhancement of cardiac myofilament Ca(2+) sensitivity. However, the upstream molecular events that link cellular stretch to the length-dependent myofilament Ca(2+) sensitivity are poorly understood. Because the angiotensin II type 1 receptor (AT1R) and the multifunctional transducer protein β-arrestin have been shown to mediate mechanosensitive cellular signaling, we tested the hypothesis that these two proteins are involved in the Frank-Starling mechanism of the heart...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911332/type-0-spinal-muscular-atrophy-further%C3%A2-delineation-of-prenatal-and%C3%A2-postnatal-features-in-16-patients
#20
Sarah Grotto, Jean-Marie Cuisset, Stéphane Marret, Séverine Drunat, Patricia Faure, Séverine Audebert-Bellanger, Isabelle Desguerre, Vincent Flurin, Anne-Gaëlle Grebille, Anne-Marie Guerrot, Hubert Journel, Gilles Morin, Ghislaine Plessis, Sylvain Renolleau, Joëlle Roume, Brigitte Simon-Bouy, Renaud Touraine, Marjolaine Willems, Thierry Frébourg, Eric Verspyck, Pascale Saugier-Veber
BACKGROUND: Spinal muscular atrophy (SMA) is caused by homozygous inactivation of the SMN1 gene. The SMN2 copy number modulates the severity of SMA. The 0SMN1/1SMN2 genotype, the most severe genotype compatible with life, is expected to be associated with the most severe form of the disease, called type 0 SMA, defined by prenatal onset. OBJECTIVE: The aim of the study was to review clinical features and prenatal manifestations in this rare SMA subtype. METHODS: SMA patients with the 0SMN1/1SMN2 genotype were retrospectively collected using the UMD-SMN1 France database...
November 29, 2016: Journal of Neuromuscular Diseases
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