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ionic contrast agent MR

Kerem Ozturk, Omer Fatih Nas, Esra Soylu, Bahattin Hakyemez
OBJECTIVES: The aim of this study was to evaluate signal changes in the dentate nucleus and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images (T1 WI) in a cohort of patients who have received intrathecal macrocyclic ionic gadolinium-based contrast agent (GBCA) gadoterate meglumine. MATERIALS AND METHODS: A group of 20 patients (male/female ratio, 8:12; mean age, 39.5 ± 15.5 years) who had not received intravenous GBCA but had received an intrathecal macrocyclic ionic GBCA (plus baseline and an additional final magnetic resonance imaging [MRI] for reference) from 2012 to 2017 were retrospectively included in this institutional review board-approved study...
April 30, 2018: Investigative Radiology
Ji Ye Lee, Ji Eun Park, Ho Sung Kim, Seon-Ok Kim, Joo Young Oh, Woo Hyun Shim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim
PURPOSE: To determine whether multiple repeated administrations of gadolinium-based macrocyclic ionic MR contrast agent (MICA) are associated with intracranial gadolinium deposition and identify the predisposing factors for deposition in various clinical situations. MATERIALS AND METHODS: In this institutional review board-approved retrospective study, 385 consecutive patients who underwent MICA-enhanced MR imaging were enrolled. The dentate nucleus-to-pons (DN/P) and globus pallidus-to-thalamus (GP/Th) signal intensity (SI) ratios on unenhanced T1-weighted images were recorded by 2 independent readers and averaged...
2017: PloS One
Xiao-Yu Zheng, Kai Zhao, Jinglong Tang, Xin-Yu Wang, Lin-Dong Li, Nai-Xiu Chen, Yan-Jie Wang, Shuo Shi, Xiaodong Zhang, Sivakumar Malaisamy, Ling-Dong Sun, Xiaoying Wang, Chunying Chen, Chun-Hua Yan
Magnetic resonance imaging contrast agents with both significantly enhanced relaxivity and minimal safety risk are of great importance for sensitive clinical diagnosis, but have rarely been reported. Herein, we present a simple strategy to improve relaxivity by introducing surface ligands with strong interaction to water molecules. As a proof of concept, NaGdF4 nanoparticles (NPs) capped by poly(acrylic acid) (PAA) show superior relaxivity to those capped by polyethylenimine and polyethylene glycol, which is attributed to the strong hydrogen-bond capacity of PAA to water molecules as revealed by theoretical calculation...
April 25, 2017: ACS Nano
Jasleen Kaur, Yoanna Tsvetkova, Karim Arroub, Sabri Sahnoun, Fabian Kiessling, Sanjay Mathur
DO3A-based macrocycles serve as attractive templates from which clinically useful theranostic agents can be obtained after coupling with molecular targeted therapeutic drugs. In this study, we describe the chemical synthesis, relaxation, and cytotoxicity studies of a new DO3A conjugate of chlorambucil (CHL) as a magnetic resonance imaging (MRI) theranostic agent. A convenient route of synthesis is reported, which allowed conjugation of the macrocyclic ligand (DO3A) to the chemotherapeutic drug (CHL) via tyrosine for the preparation of an attractive chelate-drug ensemble (DO3A-TR-CHL)...
February 2017: Chemical Biology & Drug Design
Ying Li, Gang Liu, Xin Lou, Zhiye Chen, Lin Ma
This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0...
January 2017: Science China. Life Sciences
Alessandro Furlan, Amir A Borhani, Matthew T Heller, Robinson K Yu, Mitchell E Tublin
Gadoxetate disodium (Gd-EOB-DTPA) is a linear, non-ionic paramagnetic MR contrast agent with combined extracellular and hepatobiliary properties commonly used for several liver indications. Although gadoxetate disodium is commonly used for detection and characterization of focal lesions, a spectrum of diffuse disease processes can affect the hepatobiliary phase of imaging (i.e., when contrast accumulates within the hepatocytes). Non-focal signal abnormalities during the hepatobiliary phase can be seen with multiple disease processes such as deposition disorders, infiltrating tumors, vascular diseases, and post-treatment changes...
July 2016: Abdominal Radiology
Abdolhossein Zarrin, Somayeh Sadighian, Kobra Rostamizadeh, Omidreza Firuzi, Mehrdad Hamidi, Soliman Mohammadi-Samani, Ramin Miri
In this study, the aim was to introduce and characterize a new trimodally-targeted nanomagnetic onco-theranostic system for simultaneous early diagnosis and efficient treatment of cancer. The onco-theranostic system was designed as it could target the tumor site through three targeting approach, i.e. magnetic, folic acid receptor, and pH sensitivity, and concurrently, due to the presence of superparamagnetic iron oxide nanoparticles (SPIONs) with super paramagnetic characteristics could be useful as MRI contrast agent for early cancer diagnosis...
March 16, 2016: International Journal of Pharmaceutics
Yan Cao, Daisy Q Huang, George Shih, Martin R Prince
OBJECTIVE: The objective of this study was to evaluate signal changes in the dentate nucleus on unenhanced T1-weighted MR images after multiple administrations of gadopentetate dimeglumine versus gadobutrol. MATERIALS AND METHODS: Two study groups were identified, each of which included 25 consecutive patients. Each group received six or more administrations of either gadobutrol only or gadopentetate dimeglumine only, without having had exposure to any other gadolinium-based contrast agent (GBCA)...
February 2016: AJR. American Journal of Roentgenology
O Bruder, S Schneider, G Pilz, A C van Rossum, J Schwitter, D Nothnagel, M Lombardi, S Buss, A Wagner, S Petersen, S Greulich, C Jensen, E Nagel, U Sechtem, H Mahrholdt
OBJECTIVES: Specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population. BACKGROUND: We sought to re-evaluate the frequency, manifestations, and severity of acute adverse reactions associated with administration of several gadolinium- based contrast agents during routine CMR on a European level. METHODS: Multi-centre, multi-national, and multi-ethnical registry with consecutive enrolment of patients in 57 European centres...
July 14, 2015: Journal of Cardiovascular Magnetic Resonance
Joana Ramalho, Mauricio Castillo, Mamdoh AlObaidy, Renato H Nunes, Miguel Ramalho, Brian M Dale, Richard C Semelka
PURPOSE: To determine if a correlation exists between the number of previous enhanced magnetic resonance (MR) imaging examinations and high signal intensity in the globus pallidus (GP) and dentate nucleus (DN) in patients who received gadodiamide (Omniscan), a linear nonionic gadolinium-based contrast agent, and in those who received gadobenate dimeglumine (MultiHance), a linear ionic contrast agent. MATERIALS AND METHODS: Institutional review board approval was obtained for this single-center retrospective study, with waiver of informed consent...
September 2015: Radiology
Qijun Du, Tengchuang Ma, Changhui Fu, Tianlong Liu, Zhongbing Huang, Jun Ren, Haibo Shao, Ke Xu, Fangqiong Tang, Xianwei Meng
The combination of therapies and monitoring the treatment process has become a new concept in cancer therapy. Herein, gelatin-based microcapsules have been first reported to be used as microwave (MW) susceptible agent and magnetic resonance (MR) imaging contrast agent for cancer MW thermotherapy. Using the simple coacervation methods, ionic liquid (IL) and Fe3O4 nanoparticles (NPs) were wrapped in microcapsules, and these microcapsules showed good heating efficacy in vitro under MW irradiation. The results of cell tests indicated that gelatin/IL@Fe3O4 microcapsules possessed excellent compatibility in physiological environments, and they could effectively kill cancer cells with exposure to MW...
June 24, 2015: ACS Applied Materials & Interfaces
Valeria Romeo, Alfredo Esposito, Simone Maurea, Luigi Camera, Pier Paolo Mainenti, Giovannella Palmieri, Carlo Buonerba, Marco Salvatore
BACKGROUND: Cystic thymoma is a rare variant of thymic neoplasm characterized by almost complete cystic degeneration with mixed internal structure. We describe a case of a 60 year-old woman with a cystic thymoma studied with advanced tomographic imaging stydies. CT, MRI and PET/CT with (18)F-FDG were performed; volumetric CT and MRI images provided better anatomic evaluation for pre-operative assessment, while PET/CT was helpful for lesion characterization based on (18)F-FDG uptake. Although imaging studies are mandatory for pre-operative evaluation of cystic thymoma, final diagnosis still remains surgical...
2015: Polish Journal of Radiology
Nikorn Pothayee, Der-Yow Chen, Maria A Aronova, Chunqi Qian, Nadia Bouraoud, Stephen Dodd, Richard D Leapman, Alan P Koretsky
Manganese-block copolymer complexes (MnBCs) that contain paramagnetic Mn ions complexed with ionic-nonionic poly(ethylene oxide-b-poly(methacrylate) have been developed for use as a T1-weighted MRI contrast agent. By encasing Mn ion within ionized polymer matrices, r1 values could be increased by 250-350 % in comparison with free Mn ion at relative high fields of 4.7 to 11.7 T. MnBCs were further manipulated by treatment with NaOH to achieve more stable complexes (iMnBCs). iMnBCs delayed release of Mn2+ which could be accelerated by low pH, indeed by cellular uptake via endocytosis into acidic compartments...
2014: Journal of Materials Chemistry. B, Materials for Biology and Medicine
Evan R Trivedi, Zhidong Ma, Emily A Waters, Keith W Macrenaris, Rohit Subramanian, Anthony G M Barrett, Thomas J Meade, Brian M Hoffman
Porphyrazines (Pz), or tetraazaporphyrins, are being studied for their potential use in detection and treatment of cancer. Here, an amphiphilic Cu-Pz-Gd(III) conjugate has been prepared via azide-alkyne Huisgen cycloaddition or 'click' chemistry between an azide functionalized Pz and alkyne functionalized DOTA-Gd(III) analog for use as an MRI contrast agent. This agent, Cu-Pz-Gd(III), is synthesized in good yield and exhibits solution-phase ionic relaxivity (r1  = 11.5 mM(-1) s(-1)) that is approximately four times higher than that of a clinically used monomeric Gd(III) contrast agent, DOTA-Gd(III)...
July 2014: Contrast Media & Molecular Imaging
Michael A Bruckman, Xin Yu, Nicole F Steinmetz
Magnetic resonance imaging (MRI) is a noninvasive imaging technique capable of obtaining high-resolution anatomical images of the body. Major drawbacks of MRI are the low contrast agent sensitivity and inability to distinguish healthy tissue from diseased tissue, making early detection challenging. To address this technological hurdle, paramagnetic contrast agents have been developed to increase the longitudinal relaxivity, leading to an increased signal-to-noise ratio. This review focuses on methods and principles that enabled the design and engineering of nanoparticles to deliver contrast agents with enhanced ionic relaxivities...
November 22, 2013: Nanotechnology
Anne H Schmieder, Patrick M Winter, Todd A Williams, John S Allen, Grace Hu, Huiying Zhang, Shelton D Caruthers, Samuel A Wickline, Gregory M Lanza
PURPOSE: To assess the dependence of neovascular molecular magnetic resonance (MR) imaging on relaxivity (r1) of αvβ3-targeted paramagnetic perfluorocarbon (PFC) nanoparticles and to delineate the temporal-spatial consistency of angiogenesis assessments for individual animals. MATERIALS AND METHODS: Animal protocols were approved by the Washington University Animal Studies Committee. Proton longitudinal and transverse relaxation rates of αvβ3-targeted and nontargeted PFC nanoparticles incorporating gadolinium diethylenetrianime pentaacedic acid (Gd-DTPA) bisoleate (BOA) or gadolinium tetraazacyclododecane tetraacetic acid (Gd-DOTA) phosphatidylethanolamine (PE) into the surfactant were measured at 3...
August 2013: Radiology
Alireza Shalviri, Warren D Foltz, Ping Cai, Andrew M Rauth, Xiao Yu Wu
A new multifunctional terpolymeric system for simultaneous imaging and drug delivery has been recently developed in our laboratory. Herein we report the investigation of terpolymeric contrast agent for magnetic resonance imaging and doxorubicin (Dox) delivery. The polymer was synthesized by graft polymerization of methacrylic acid (MAA) and polysorbate 80 (PS 80) onto starch with multiple, chemically bound diethylenetriaminepenta acetic acid (DTPA) groups for gadolinium chelating. The terpolymer self-assembled to form nanoparticles upon addition of doxorubicin which binds with the PMAA chain...
April 10, 2013: Journal of Controlled Release: Official Journal of the Controlled Release Society
Noboru Maeda, Keigo Osuga, Kouki Shimazu, Eiichi Morii, Koji Mikami, Shinichi Hori, Tetsuro Nakazawa, Hiroki Higashihara, Kaname Tomoda, Hironobu Nakamura, Noriyuki Tomiyama
PURPOSE: To investigate the pharmacokinetics and efficacy of chemoembolization with a cisplatin-loaded superabsorbent polymer (SAP) suspension in a rabbit model with transplanted liver VX2 tumors. MATERIALS AND METHODS: VX2 tumors were implanted into the left lobe of the liver in eight rabbits. Embolization of the proper hepatic artery was performed with cisplatin-loaded or unloaded SAP. In the cisplatin-loaded SAP group (n = 4), 5 mg of SAP (106-150 μm) loading 2...
March 2012: Journal of Vascular and Interventional Radiology: JVIR
Wei Li, Robert R Edelman, Pottumarthi V Prasad
PURPOSE: To evaluate the potential difference in post-contrast T(1) relaxation time of the meniscus (T(1Gd)) between osteoarthritic patients (OA) and healthy subjects (HS), and to verify if charge density has any influence on meniscal T(1Gd). MATERIALS AND METHODS: We performed a retrospective analysis of meniscal T(1) relaxation time on data previously acquired for studying articular cartilage with both ionic and non-ionic contrast media. MR imaging was performed in 10 OA and 8 HS at 120 min following administration of double-dose ionic Gd-DTPA(2-) on one day and non-ionic Gd-DTPA-BMA on a different day...
March 2011: Journal of Magnetic Resonance Imaging: JMRI
Soon Hong Yuk, Keun Sang Oh, Sun Hang Cho, Beom Suk Lee, Sang Yoon Kim, Byung-Kook Kwak, Kwangmeyung Kim, Ick Chan Kwon
We described the preparation of the glycol chitosan/heparin immobilized iron oxide nanoparticles (composite NPs) as a magnetic resonance imaging agent with a tumor-targeting characteristic. The iron oxide nanoseeds used clinically as a magnetic resonance imaging agent were immobilized into the glycol chitosan/heparin network to form the composite NPs. To induce the ionic interaction between the iron oxide nanoseeds and glycol chitosan, gold was deposited on the surface of iron oxide nanoseeds. After the immobilization of gold-deposited iron oxide NPs into the glycol chitosan network, the NPs were stabilized with heparin based on the ionic interaction between cationic glycol chitosan and anionic heparin...
June 13, 2011: Biomacromolecules
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