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https://www.readbyqxmd.com/read/29782209/practical-assessment-and-management-of-vulnerabilities-in-older-patients-receiving-chemotherapy-asco-guideline-for-geriatric-oncology
#1
Supriya G Mohile, William Dale, Mark R Somerfield, Mara A Schonberg, Cynthia M Boyd, Peggy S Burhenn, Beverly Canin, Harvey Jay Cohen, Holly M Holmes, Judith O Hopkins, Michelle C Janelsins, Alok A Khorana, Heidi D Klepin, Stuart M Lichtman, Karen M Mustian, William P Tew, Arti Hurria
Purpose To provide guidance regarding the practical assessment and management of vulnerabilities in older patients undergoing chemotherapy. Methods An Expert Panel was convened to develop clinical practice guideline recommendations based on a systematic review of the medical literature. Results A total of 68 studies met eligibility criteria and form the evidentiary basis for the recommendations. Recommendations In patients ≥ 65 years receiving chemotherapy, geriatric assessment (GA) should be used to identify vulnerabilities that are not routinely captured in oncology assessments...
May 21, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29568805/status-and-determinants-of-health-services-utilization-among-elderly-migrants-in-china
#2
Xiaofang Zhang, Bin Yu, Tiantian He, Peigang Wang
Background: The household registration system in China places migrants in a vulnerable status regarding access to local public services, including limited access to health services. Most studies on migrants' health services utilization targeted on working-age migrants, and there has been a paucity of studies conducted among elderly migrants. This study aims to investigate the status of health services utilization and its influential factors among elderly migrants. Methods: Data (13,043 participants, 52...
2018: Global Health Research and Policy
https://www.readbyqxmd.com/read/29540293/geriatric-oncology-screening-tools-for-cga-based-interventions-results-from-a-phase-ii-study-of-geriatric-assessment-and-management-for-older-adults-with-cancer
#3
Daniel W Yokom, Shabbir M H Alibhai, Schroder Sattar, Monika K Krzyzanowska, Martine T E Puts
INTRODUCTION: Screening tools in geriatric oncology have traditionally been studied for their ability to identify patients who have abnormal domains on a comprehensive geriatric assessment (CGA). However, an alternative outcome of identifying patients who would receive CGA-based interventions could improve selection of patients whose management will be altered by a CGA. The objective of this study was to assess the performance of three geriatric oncology screening tools for their ability to predict for CGA-based interventions...
March 12, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29532057/association-of-excessive-daytime-sleepiness-with-longitudinal-%C3%AE-amyloid-accumulation-in-elderly-persons-without-dementia
#4
Diego Z Carvalho, Erik K St Louis, David S Knopman, Bradley F Boeve, Val J Lowe, Rosebud O Roberts, Michelle M Mielke, Scott A Przybelski, Mary M Machulda, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri
Importance: Aging is associated with excessive daytime sleepiness (EDS), which has been linked to cognitive decline in the elderly. However, whether EDS is associated with the pathologic processes of Alzheimer disease remains unclear. Objective: To investigate whether EDS at baseline is associated with a longitudinal increase in regional β-amyloid (Aβ) accumulation in a cohort of elderly individuals without dementia. Design, Setting, and Participants: This prospective analysis included participants enrolled in the Mayo Clinic Study of Aging, a longitudinal population-based study in Olmsted County, Minnesota...
March 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29381689/geriatric-assessment-may-help-decision-making-in-elderly-patients-with-inoperable-locally-advanced-non-small-cell-lung-cancer
#5
Maite Antonio, Juana Saldaña, Jennifer Linares, José C Ruffinelli, Ramón Palmero, Arturo Navarro, Maria Dolores Arnaiz, Isabel Brao, Samantha Aso, Susana Padrones, Valentí Navarro, Jesús González-Barboteo, Josep Maria Borràs, Felipe Cardenal, Ernest Nadal
BACKGROUND: Although concurrent chemoradiotherapy (cCRT) increases survival in patients with inoperable, locally advanced non-small-cell lung cancer (NSCLC), there is no consensus on the treatment of elderly patients. The aim of this study was to determine the prognostic value of the comprehensive geriatric assessment (CGA) and its ability to predict toxicity in this setting. METHODS: We enrolled 85 consecutive elderly (⩾75 years) participants, who underwent CGA and the Vulnerable Elders Survey (VES-13)...
March 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29362300/-prognostic-value-of-geriatric-screening-tools-in-elderly-cancer-patients
#6
Masahiro Takahashi
The elderly population is heterogeneous. Chronological age alone does not reflect heterogeneity in the aging process. It is recommended that elderly cancer patients should be evaluated for some form of geriatric assessment(GA)to detect problems, to predict treatment-related toxicities, to predict functional decline, to predict prognosis, and to assist in cancer treatment decisions. It was reported that functional status, nutritional status, mental status, polypharmacy, and comorbidity were independent prognostic factors for survival in elderly cancer patients...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29126383/predictive-performance-of-four-frailty-screening-tools-in-community-dwelling-elderly
#7
Bienvenu Bongue, Aurélie Buisson, Caroline Dupre, François Beland, Régis Gonthier, Émilie Crawford-Achour
BACKGROUND: This study compares the performance of four frailty screening tools in predicting relevant adverse outcome (disability, institutionalization and mortality) in community-dwelling elderly. METHODS: Our study involved a secondary analysis of data from the FréLE cohort study. We focused on the following four frailty screening tools: the abbreviated Comprehensive Geriatric Assessment (aCGA), the Groningen Frailty Indicator (GFI), the Vulnerable Elders Survey-13 (VES-13) and the Fried scale...
November 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29121710/effects-of-living-alone-versus-with-others-and-of-housemate-type-on-smoking-drinking-dietary-habits-and-physical-activity-among-elderly-people
#8
Seungmin Jeong, Sung Il Cho
OBJECTIVES: This study examined differences in health behaviors between elderly people living alone and with others; it also investigated whether the effect of living with others differs according to housemate type, namely a spouse and/or younger generations. METHODS: Gender-stratified data from the 2013 Korea Community Health Survey for individuals aged 60 to 74 living in Seoul were analyzed. Logistic regression modeling was conducted to obtain odds ratios (ORs) and 95% confidence intervals (CIs) of the outcome variables (smoking, drinking, eating salty foods, inactive lifestyle) for the variables of interest (living alone/with others, housemate type)...
2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28957686/the-linear-relationship-between-the-vulnerable-elders-survey-13-score-and-mortality-in-an-asian-population-of-community-dwelling-older-persons
#9
Jye Wang, Wender Lin, Ling-Hui Chang
BACKGROUND: The Vulnerable Elders Survey-13 (VES-13) has been used as a screening tool to identify vulnerable community-dwelling older persons for more in-depth assessment and targeted interventions. Although many studies supported its use in different populations, few have addressed Asian populations. The optimal scaling system for the VES-13 in predicting health outcomes also has not been adequately tested. This study (1) assesses the applicability of the VES-13 to predict the mortality of community-dwelling older persons in Taiwan, (2) identifies the best scaling system for the VES-13 in predicting mortality using generalized additive models (GAMs), and (3) determines whether including covariates, such as socio-demographic factors and common geriatric syndromes, improves model fitting...
January 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28905751/re-which-better-predicts-mortality-among-older-men-a-prostate-cancer-pca-diagnosis-or-vulnerability-on-the-vulnerable-elders-survey-ves-13-a-retrospective-cohort-study
#10
https://www.readbyqxmd.com/read/28743505/short-physical-performance-battery-usual-gait-speed-grip-strength-and-vulnerable-elders-survey-each-predict-functional-decline-among-older-women-with-breast-cancer
#11
COMPARATIVE STUDY
Cynthia Owusu, Seunghee Margevicius, Mark Schluchter, Siran M Koroukian, Nathan A Berger
OBJECTIVE: To determine the ability of three performance-based measures [Short Physical Performance Battery (SPPB), gait speed, and Grip Strength] and a self-report measure [Vulnerable Elders Survey (VES-13)] to predict functional decline among older women with breast cancer. PATIENTS AND METHODS: Longitudinal data from a study of women ≥65years, with newly diagnosed stages I-III breast cancer, recruited from ambulatory oncology clinics between July 2010 and April 2014, was used...
September 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28712144/frailty-is-an-independent-prognostic-marker-in-elderly-patients-with-myocardial-infarction
#12
Gonzalo Luis Alonso Salinas, Marcelo Sanmartin, Marina Pascual Izco, Luis Miguel Rincon, Pablo Pastor Pueyo, Alvaro Marco Del Castillo, Alberto Garcia Guerrero, Pedro Caravaca Perez, Alejandro Recio-Mayoral, Asuncion Camino, Manuel Jimenez-Mena, José Luis Zamorano
BACKGROUND: Acute coronary syndrome (ACS) patients are increasingly older. Conventional prognostic scales include chronological age but do not consider vulnerability. In elderly patients, a frail phenotype represents a better reflection of biological age. HYPOTHESIS: This study aims to determine the prevalence of frailty and its influence on patients age ≥75 years with ACS. METHODS: Patients age ≥75 years admitted due to type 1 myocardial infarction were included in 2 tertiary hospitals, and clinical data were collected prospectively...
October 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28666448/catastrophic-healthcare-expenditure-and-its-inequality-for-households-with-hypertension-evidence-from-the-rural-areas-of-shaanxi-province-in-china
#13
Yafei Si, Zhongliang Zhou, Min Su, Meng Ma, Yongjian Xu, Jesse Heitner
BACKGROUND: China has been undergoing tremendous demographic and epidemiological transitions during the past three decades and increasing burden from non-communicable diseases and an ageing population have presented great health-care challenges for the country. Numerous studies examine catastrophic healthcare expenditures (CHE) worldwide on whole populations rather than specific vulnerable groups. As hypertension and other chronic conditions impose a growing share of the disease burden in China, they will become an increasingly important component of CHE...
July 1, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28620770/access-to-information-on-home-and-community-based-services-and-functional-status
#14
Anne Cattagni Kleiner, Brigitte Santos-Eggimann, Sarah Fustinoni, Laurence Seematter-Bagnoud
OBJECTIVES: To examine differences in access to home- and community-based service (HCBS) information among older adults of different functional status. METHODS: Cross-sectional survey of 5435 out of 11,000 randomly selected Swiss older community dwellers from the state of Vaud. Analyses stratified by functional status examined characteristics associated with limited access to HCBS information, based on self-reported knowledge on where to find information on 13 HCBS...
March 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/28602709/factors-associated-with-the-use-of-potentially-inappropriate-medications-by-older-adults-with-cancer
#15
Cristiane Moreira Reis, Andrezza Gouvêa Dos Santos, Paula de Jesus Souza, Adriano Max Moreira Reis
OBJECTIVES: To determine the frequency and the factors associated with the use of potentially inappropriate medications (PIMs) by older adults with cancer at an onco-haematology ambulatory clinic of a teaching hospital in Brazil. MATERIAL AND METHODS: Patients aged 60years or older (n=160) subjected to parenteral antineoplastic chemotherapy from May to December 2015 and treated with one or more medications in the ambulatory clinic were interviewed. Data on medications, comorbidities, oncological diagnosis, and functional status were recorded...
July 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28592379/comprehensive-geriatric-assessment-in-men-aged-70-years-or-older-with-localised-prostate-cancer-undergoing-radical-radiotherapy
#16
G E C Osborne, S A Appleyard, D C Gilbert, C I Jones, C Lorimer, M Villanueva, E Peasgood, A Robinson, A Nikapota, A Ring
AIMS: Treatment decisions for men aged 70 years or over with localised prostate cancer need to take into account the risk of death from competing causes and fitness for the proposed treatment. Objective assessments such as those included in a comprehensive geriatric assessment (CGA) might help to inform the decision-making process. The aim of this study was to describe the CGA scores of a cohort of older men with prostate cancer, evaluate potential screening tools in this population and assess whether any CGA component predicts significant acute radiotherapy toxicity...
September 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28471574/frailty-transitions-in-community-dwelling-older-people
#17
Netta Bentur, Shelley A Sternberg, Jennifer Shuldiner
BACKGROUND: Frailty is a dynamic process with transitions over time. OBJECTIVES: To examine frailty transitions and their relationship to utilization of health services. METHODS: Frailty status using the Vulnerable Elders Survey (VES-13) was determined for 608 community-dwelling older people interviewed in a 2008 national survey and for 281 re-interviewed in 2014. The effect of frailty on death 6 years later was assessed using Cox proportional hazards analysis...
August 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28405846/cancer-specific-geriatric-assessment-and-quality-of-life-important-factors-in-caring-for-older-patients-with-aggressive-b-cell-lymphoma
#18
MULTICENTER STUDY
Karin Ribi, Stéphanie Rondeau, Felicitas Hitz, Ulrich Mey, Milica Enoiu, Thomas Pabst, Anastasios Stathis, Natalie Fischer, Kerri M Clough-Gorr
PURPOSE: To evaluate the efficacy and tolerability of chemotherapy, a geriatric assessment is recommended in elderly patients with cancer. We aimed to characterize and compare patients with aggressive lymphoma by objective response and survival status based on pre-treatment cancer-specific geriatric (C-SGA) and quality of life (QoL) assessments. METHODS: Patients not eligible for anthracycline-based first-line therapy or intensive salvage regimens completed C-SGA and QoL assessment before and after a rituximab-bendamustine-lenalidomide (R-BL) treatment in a phase II clinical trial...
September 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28369691/adapting-the-vulnerable-elders-survey-13-to-predict-mortality-using-responses-to-the-medicare-health-outcomes-survey
#19
Megan K Beckett, Marc N Elliott, Douglas Ritenour, Laura A Giordano, Susan C Grace, Rochelle Malinoff, Debra Saliba
OBJECTIVES: To use items from the Medicare Health Outcomes Survey (HOS) to adapt or validate a simple method for identifying community-dwelling older adults at greater risk of death and to extend the method to identify a very high-risk group. DESIGN: Analysis of longitudinal data. SETTING: National sample of beneficiaries from Medicare Advantage plans with 500 or more enrollees. PARTICIPANTS: Medicare beneficiaries aged 65 and older responding to 2009 baseline and 2011 follow-up HOS (N = 238,687)...
May 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28320329/external-validation-of-the-vulnerable-elder-s-survey-for-predicting-mortality-and-emergency-admission-in-older-community-dwelling-people-a-prospective-cohort-study
#20
Emma Wallace, Ronald McDowell, Kathleen Bennett, Tom Fahey, Susan M Smith
BACKGROUND: Prospective external validation of the Vulnerable Elder's Survey (VES-13) in primary care remains limited. The aim of this study is to externally validate the VES-13 in predicting mortality and emergency admission in older community-dwelling adults. METHODS: Design: Prospective cohort study with 2 years follow-up (2010-2012). SETTING: 15 General Practices (GPs) in the Republic of Ireland. PARTICIPANTS: n = 862, aged ≥70 years, community-dwellers Exposure: VES-13 calculated at baseline, where a score of ≥3 denoted high risk...
March 20, 2017: BMC Geriatrics
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